Cheng Y, et al. (2013) Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy 9, 208-19 23182879

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S78-p - EEF2K (human) ▲

Modsite: ssGsPANsFHFkEAW SwissProt Entrez-Gene Orthologous residues EEF2K (human): S78‑p, EEF2K (mouse): S77‑p, EEF2K (rat): S77‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  glioblastoma multiforme, glioma Relevant cell lines - cell types - tissues:  T98G (glial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thapsigargin increase Downstream Regulation Effect of modification (process):  autophagy, inhibited

S366-p - EEF2K (human) ▲

Modsite: sPQVRtLsGSRPPLL SwissProt Entrez-Gene Orthologous residues EEF2K (human): S366‑p, EEF2K (mouse): S365‑p, EEF2K (rat): S365‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  glioblastoma multiforme, glioma Relevant cell lines - cell types - tissues:  T98G (glial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thapsigargin increase Downstream Regulation Effect of modification (process):  autophagy, inhibited

S398-p - EEF2K (human) ▲

Modsite: DsLPssPssAtPHSQ SwissProt Entrez-Gene Orthologous residues EEF2K (human): S398‑p, EEF2K (mouse): S397‑p, EEF2K (rat): S397‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  glioblastoma multiforme, glioma Relevant cell lines - cell types - tissues:  T98G (glial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE AMPKA2 (human) phospho-antibody, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes thapsigargin increase Downstream Regulation Effect of modification (process):  apoptosis, inhibited, autophagy, induced