Kinase, in vitro: 

An enzyme-substrate reaction that occurs in non-living experimental conditions such as a test tube. For example, a purified enzyme is reacted with a substrate protein or mixture of proteins or peptides.

Akt1 T45-p
Akt2 T45-p
AurA S10-p
AurB S10-p
AurB T3-p , S10-p , S28-p
CDK8 S10-p
Chk1 T11-p
Haspin T3-p
IGF1R Y41-p
IKKA S10-p
JAK1 Y41-p
JAK2 Y41-p
MSK1 S10-p , S28-p
MSK2 S28-p
PAK1 S10-p
PBK S10-p
Pim1 S10-p
PKCA T6-p
PKCB T6-p
PKCD T45-p
PKM iso2 T11-p
PKN1 T11-p
ROCK1 S10-p , S28-p
RSK2 S10-p
RSK2 S10-p
TLK1 S10-p
VRK1 T3-p , S10-p
ZAK S28-p
 Putative in vivo kinases: 

An enzyme-substrate reaction that occurs within living cells; includes cultured cells, ex vivo samples, and intact organisms. In the case of kinases, the large number of protein kinases in intact cells makes exact identification of the responsible kinase challenging.

Akt1 T45-p
Akt2 S10-p , S28-p , T45-p
AurA S10-p
AurB S10-p , S28-p
AurC S10-p
CDK8 S10-p
ChaK2 T3-p , T6-p
Haspin T3-p
IGF1R Y41-p
JAK2 Y41-p
MSK1 S10-p , S28-p
PAK1 S10-p
PBK S10-p
Pim1 S10-p
PKACA S10-p
PKCB T6-p
PKCD T45-p
PKCT S10-p
PKM iso2 T11-p
PKN1 T11-p
ROCK1 S10-p
TGM2 S10-p , S28-p
TLK1 S10-p
VRK1 T3-p , S10-p
ZAK S28-p
Phosphatases, in vitro:
PPP1CA S10-p
PPP1CC T11-p
Putative upstream phosphatases:
PPP2CA S10-p
PPP2CA S10-p
Regulatory protein:
ABHD5 K4-m3
Abl S10-p
Akt1 K27-m3
Akt2 K27-m3
AMPKA1 K9-ac , K14-ac , R17-m2
AMPKA1 K27-m3
AP-2 delta K4-m3
ARPC1B S10-p
ARPP-19 S10-p
ASF1A K56-ac
ASF1B K56-ac
ASH2L K4-m2
ASXL1 K4-m3 , K27-m2
ATF-5 K14-ac
ATM S10-p
ATR T11-p
AurA S10-p , S28-p
AurB T3-p , K9-m2 , S10-p , T80-p
CCNB1 S10-p
CCNF S10-p , S28-p
CD82 K27-m3
CDC25A S10-p
CDCA2 T3-p , S10-p
CDK1 S10-p , T11-p
CDK2 K9-m2 , T11-p
CDK8 K14-ac
ChaK2 S10-p , T11-p
Chk1 S10-p
CtIP K9-ac
CUL4B K9-m3 , K27-m3
CYLD K9-m2 , S10-p
CYLD K9-m2
DAP3 S10-p
DAXX K27-ac
DDB1 K56-ac
DDB2 K56-ac
DNMT1 K4-m3 , K27-ac
DNMT3B K4-m3 , K27-ac
DOT1L K36-m3
E2F1 K9-ac
EHMT1 K9-m2
EHMT2 K9-m2 , K23-ub
EZH2 K9-m3 , K27-me
FBXL11 K36-m2
Fbxw15 K14-ac
FOXA1 K4-m1
FXR1 K9-ac , R17-m2
GCN5 K56-ac
Geminin S10-p
GLDC K4-m3 , K9-m3 , K27-m3 , K36-m3 , K79-m3
GLP-1 K9-me
GSK3B K27-m3
H1D K4-m2
H2A.1 K4-m2 , K36-m1 , K79-m2
H2AX K9-ac , K14-ac , K18-ac , K23-ac
H2B K4-m2 , K79-m1
H3 K36-m2
H4 K4-m2 , K36-m2 , K79-m2
HAT1 K9-ac
HBB K4-m3 , K9-m3 , K36-m3
HDAC1 K4-m2 , K9-m2 , K14-ac , K27-ac , K56-ac
HDAC2 K4-m2 , K9-ac , K14-ac , K27-ac , K56-ac
HDAC3 K4-m2 , K9-m2 , K36-m1
HDAC6 K4-m3 , K9-m3
HDAC8 K4-m3 , K9-m2
HIF1A K9-m2
HIRA K27-ac
HMG20A K4-m2
HMGN1 K9-ac
HSF1 S10-p
IKKA S10-p
INCENP S10-p
JAK2 K9-m2
JMJD1A K9-m2
JMJD1B K9-m2
JMJD2A K9-m3 , K36-m3
JMJD2C K9-m1
JMJD3 K4-me , K27-m3
KANSL3 K4-m2 , K27-m3
KRBA1 K9-m3
lamin A/C K27-m3
LSD1 K4-m1 , K9-m3 , K27-m2 , K36-m2
MAD2L1BP S10-p
MBD3 K9-ac , K14-ac
MEN1 K4-m3
MLLT10 K79-m2
MLLT3 K4-m3 , K79-m3
MSK1 K9-m2 , S10-p , K14-ac , S28-p
MST1 S10-p
MTA1 K4-m2 , K9-m2
MTHFR K4-m3 , K9-m3 , K27-m3 , K36-m2 , K79-m3
Myb K4-m2 , K9-ac
Myc K4-m2 , K9-m3 , K14-ac , K18-ac , K27-m3 , K79-m1
MYST1 K4-m2 , K9-m2
MYST2 K14-ac , K23-ac
MYST4 K23-ac
NANOG K14-ac , K27-ac
NFkB-p65 K9-ac
NIPP-1 S10-p , S28-p
NSD1 K36-m2
Oct4 S10-p , S28-p
OGT K4-m2 , K9-ac , R17-m2 , K27-m1
p21Cip1 S10-p
p300 K9-me
p53 K9-ac , S10-p , K14-ac , K27-m3
PAXIP1 K4-m3
PC4 K4-m3 , K9-m2 , K14-ac
PHB K9-m3 , Y41-p
PHF2 K27-m2
PHF8 K4-m3 , K9-m3 , K27-m2 , K36-m2
PKM iso2 T11-p
PKM S10-p , T11-p
PKN1 K9-m2 , T11-p , K14-ac
PLK1 S10-p
PPME1 K9-m3 , K27-m3
PPP1CA K9-m1
PPP1R14A T3-p , S10-p , T11-p
PPP2CA S10-p
PPP4C S10-p
PRMT1 K9-ac , K14-ac
PRMT5 R8-m2 , K9-ac , K14-ac
RBBP5 K4-m1
RGC32 K9-ac , K18-ac , K27-m3
RKIP S10-p
RNF168 R2-m1 , R8-m2
RNF20 K4-m2 , K79-m2
RNF40 K4-m3
SAFB1 K4-m2 , K27-m3
SETD2 K36-m3
SETD7 K4-m1
SETD8 K9-m2
SETDB1 K4-m3 , K27-m3
SETDB2 K4-m3 , K27-m3
SIRT1 K9-m3 , K115-ac
SIRT5 S10-p , T11-p
SIRT6 K9-ac , T11-p , K56-ac
SMARCA2 K9-ac , K14-ac , K18-ac , K23-ac , K79-m2
SMARCA4 K9-ac , K14-ac , K18-ac , K23-ac , K79-m2
SMEK2 S10-p
STAT4 K4-me , K27-m3
Survivin S10-p
SUV39H1 K9-ac
SUV39H2 K9-m3
SUZ12 K27-ac , K36-m2
TAO1 S10-p
TAO3 S10-p
TCF7L2 K9-ac
TET2 K4-m3
TET3 K4-m3
TFEB R17-m2
TIF1B K9-m3
TRF2 S10-p
TRIP13 S10-p
TRRAP K4-m3 , K9-ac
TTK S10-p
UHRF1 K4-m3 , K9-m2
USP16 S10-p
USP21 K36-m2
USP38 K56-ac
VRK3 S28-p
WDR5 K4-m1
WIZ K9-m2
WNT3A K4-ac , K27-ac
ZNF263 K9-ac , K27-m3
ZNF644 K9-m2
Treatment:
17-beta-estradiol K4-m3 , K9-m2
5'-methylthioadenosine K4-m3
5-aza-CdR K4-ac , K9-ac , K27-m2
A-485 K9-ac , K18-ac , K27-ac
A23187 K9-ac , S10-p , K14-ac
acadesine K9-ac , K14-ac
acetate K9-ac
acidosis K9-ac
adriamycin K9-m2 , S10-p , K14-ac , K18-ac , K23-ac , K27-m3 , S28-p , T45-p
AEBSF K4-m1 , K9-m2 , S10-p , K27-m3
Akt-I-1,2 K27-m3
Akt_inhibitor_IV T45-p
alloxan K4-m3
alpelisib K4-m3
alpha2-macroglobulin S10-p
alvocidib S10-p
amanitin K9-m2 , K36-m3
ambient air polution K4-m3 , K36-m3
AMI-1 K27-ac
amino_acid_starvation K4-m3 , K9-m3 , R17-m2 , K36-m3
amphidicolin K9-m2
androstanolone K4-m1 , T6-p , K9-m1 , T11-p
anisomycin S10-p , K14-ac , K27-m2 , S28-p
aphidicolin T11-p
APIO-EE-9 S10-p
AR42 K4-me , K9-m3
arcyriarubin_A T6-p
arsenite S10-p
As2O3 S10-p , K23-sm
aspirin K56-ac , K122-ac
AT9283 Y41-p
ATP S10-p , Y41-p
AzaC K4-me , K9-m2 , K14-ac , K27-m3
AZD1152 S10-p
AZD1480 Y41-p
AZD1775 S10-p
AZD6482 K4-m3
AZD7762 S10-p
bacterial infection K4-ac , K9-ac , S10-p , K14-ac , K18-ac , K23-ac , K27-ac , K56-ac
BAPTA-AM S10-p
Bergamottin S10-p
BI2536 S10-p
bisindolylmaleimide T6-p
BIX01294 K9-m2
BL-I S10-p
blebbistatin S10-p
bleomycin T11-p
BMP4 K27-m3
BMS-3031 K9-ac
BMX K9-ac , K14-ac
bortezomib K9-ac , K14-ac , K36-m3
butyrate K4-m3 , K9-ac , S10-p , K18-ac , K56-ac
BX795 S10-p
C5M S10-p
C646 K9-ac , K18-ac , K27-ac
C8 MCT Oil Supplement K9-ac , K14-ac
Ca(2+) R17-me
caffeine S10-p , T11-p
calphostin_C S10-p
calyculin_A T45-p
camptothecin R2-m2 , K9-ac , S10-p , K14-ac , K36-m3 , K56-ac
CD532 S10-p
CDCA K9-ac , R17-m2
cell cycle regulated K9-m3 , S10-p , K79-m2
CEP-33779 K9-m3
CFI-402257 S10-p
chaetocin K9-m2
CHR-6494 T3-p , S10-p , S28-p
ciclosporin S10-p
ciglitazone K9-ac
CIL-102 K4-ac
cisplatin S10-p , S28-p
CM272 K9-m2
cocaine S10-p
CoCl2 K4-m3 , K9-m3 , K27-m3 , K36-m3
colcemid S10-p , K79-m3 , T80-p
colforsin K9-m1
compound 1 K9-ac
compound 2 K9-ac
compound_3 K9-ac
compound_8 K9-ac
ConA S10-p , K14-ac
CPT S10-p
curcumin K56-ac
cycloheximide K9-m2 , S10-p
D9 K4-m3 , K9-m3 , K27-m3 , K36-m2 , K79-m3
dabrafenib K4-m3 , K9-m3 , K27-m3
DCA K9-ac
DDATHF K9-ac , K14-ac
deferoxamine K9-m2 , K27-m3
depsipeptide K4-m3 , K9-m3 , S10-p , K14-ac , K27-ac
dexamethasone K4-m1 , K9-ac , S10-p , K14-ac , R17-me , S28-p
Dia2 K79-m2
differentiation K27-m3
DMOG K9-m2
docetaxel K4-m3 , K9-m3 , K27-m3
doxycycline K9-m2 , K27-m2
DRB K9-ac , K56-ac
DSBs K36-m3
DTBR K9-ac , S10-p , S28-p , K56-ac
DZNep K9-m3 , K27-ac
EGF K4-ub , S10-p , T11-p , K14-ac , K27-ac , S28-p
EGTA S10-p
ellagic acid K14-ac , R17-m2 , K18-ac , R26-m2
EPZ004777 K79-m2
EPZ015666 R2-m1 , R8-m2
estradiol K9-ac , S10-p , K14-ac , R17-me , K18-ac , K23-ac
etoposide K4-m3 , K9-ac , S10-p , K14-ac , K36-m2 , T45-p
exercise K9-ac , K14-ac , K36-ac
Farnesiferol C K18-ac
fedratinib K9-m3 , Y41-p
ferric ammonium citrate K9-m2 , K27-m3
FH535 K4-ac , K27-ac
FIDAS-5 K4-m3 , K9-m3 , K27-m3 , K36-m3 , K79-m3
formate K4-m3 , K9-m3 , K27-m3 , K36-m2 , K79-m3
fostriecin T11-p
G-CSF T45-p
geldanamycin K9-m3
gemcitabine S10-p
genistein K4-m2 , K9-m2 , S10-p
glucose K9-ac
glucose_starvation K4-m3 , K9-ac , T11-p , R17-m2 , K36-m3
GnRH K4-m3
gold nanoparticles K9-ac , S10-p , K14-ac
GSK-J4 K27-m3
GSK126 K9-m3 , K27-m3
GSK343 K27-m3
GSK467 K4-m3
GW_9662 K27-m3
H-89 S10-p , K14-ac , K27-m2 , S28-p
H-Leu-Leu-OMe K4-m1 , K9-m2 , S10-p , K27-m3
H2O2 R2-m2 , K9-ac , K14-ac , K56-ac
heat_shock K9-m2 , S10-p
heating K4-me , K9-me
hemorrhage K9-ac , K14-ac , K18-ac
hesperadin K9-m3 , S10-p , K14-ac
high-fat diet K14-ac
histidinol K4-m3
HO53 K27-m3
homocysteine K4-m3 , K9-m3 , K27-m3 , K36-m2 , K79-m3
HXDV S10-p
hydroxyurea S10-p , K56-ac
hypertonic_buffer K9-ac , K14-ac , K18-ac
hypoxia K4-m3 , K9-m2
IFN-alpha K36-m3
IFN-gamma K4-m3
IL-11 K9-m2
IL-12 K4-me , K27-m3
IL-1b S10-p , K27-ac
IL-6 K9-m2
imatinib K18-ac
InSolution T45-p
ionizing_radiation R2-m2 , K9-m3 , S10-p , T11-p , K14-ac , K18-ac , K23-ac , K56-ac , K79-m2
JIB04 K9-m2
JNK_inhibitor_I S10-p
KN-62 S10-p
KNK437 K4-me , K9-me
KU-55933 K9-ac , K56-ac
L-lactated Ringer’s K14-ac
lactated Ringer’s K9-ac , K14-ac
LBH-589 K9-ac , K14-ac , K18-ac , K56-ac
LIF Y41-p
liothyronine K4-m2 , K9-ac , K14-ac , K18-ac
LLY-507 K4-m3 , K9-m2 , K14-ac , K27-m1 , K36-me , K79-m1
LPS K4-me , K9-me , S10-p , K14-ac , K27-m3
LY294002 K4-ac , K9-ac , K18-ac , K27-ac
MB05032 K27-m3
medium change K9-ac , K56-ac
metformin K9-m2
methionine-deficient medium K4-m3 , K9-m3 , K27-m3 , K36-m3 , K79-m3
metribolone K9-m3 , T11-p , K14-ac , K27-m3
MG132 T3-p , S10-p , K27-m3 , K56-ub , K79-ub
MG132_withdrawal S28-p
mimosine S10-p
miR-376ac K18-ac
miR24-2 K79-m3
miRNA K9-m3 , K27-ac
MK-2206 K4-m3
MK1775 S10-p
MK5108 S10-p
MLN8054 S10-p , S28-p
MLN8237 S10-p , S28-p
MMS R2-m2 , K9-ac , K14-ac , K56-ac
MNLN8237 S10-p
monastrol S10-p
MRLB-38489 K18-ac , K23-ac
MS275 K4-me , K9-m3 , K14-ac , K23-ac , K27-ac , K79-ac , K122-ac
MTDIA R2-m1 , R8-m2
mutation K4-me , K9-me , K14-m2 , K27-m3 , K36-m2 , K79-m2
NaB K9-ac , K14-ac , K18-ac , K23-ac , K27-ac , K56-ac
nafamostat K4-m1 , K9-m2 , S10-p , K27-m3
nicotinamide K9-ac , K56-ac
nicotinic_acid K56-ac
niraparib K4-ac
NM-PP1 K4-m3
nocodazole T3-p , S10-p , T11-p , K23-ac , K27-ac , S28-p , K56-ac , K79-m3 , T118-p
okadaic_acid S10-p , T11-p
olaparib S10-p
oncostatin_M K9-m2
onvansertib S10-p
palbociclib S10-p , S28-p
pargyline K4-m2 , K9-m2
PBIT K4-m3
PD0332991 K9-m3
PD98059 K4-m2 , K9-ac , S10-p , K14-ac , S28-p
PDGF Y41-p
peptide inhibitor S10-p
PF-4708671 K27-m3
PHA-680632 S10-p
phleomycin R2-m2 , K9-ac , S10-p , K14-ac , S28-p , K56-ac
phorbol_ester K9-ac , S10-p , K14-ac , S28-p
pictilisib K4-m3
pinometostat K79-m2
PKC_inhibitor T45-p
plumbagin K9-ac , K14-ac
Poloxin S10-p
PRMT6 inhibitor R2-m2
PTC-209 K4-m3
PUGNAc K4-me , K27-m3
purvalanol T11-p
PXD101 K9-ac , K18-ac , K23-ac , K27-ac , K79-m2
rapamycin K4-m3 , K9-m3 , R17-m2 , K36-m3
resveratrol K115-ac
retinoic_acid K4-m3 , K9-m3 , K14-ac , K27-m2 , S28-p , K36-m3 , K56-ac
rigosertib S10-p
RO-3306 S10-p , T11-p
Ro31-8220 K9-m2 , T11-p , K14-ac
romidepsin K4-ac
rottlerin S10-p
ruxolitinib Y41-p
S2101 K4-m2 , K27-ac
SAM K4-m3 , K9-m3 , K27-m3 , K36-m2 , K79-m3
SB202190 S10-p , K27-m3 , S28-p
SB203580 S10-p , K27-m2 , S28-p
selisistat K9-ac
serum S10-p , K14-ac
short methylated oligonucleotide K9-m2 , K27-m3
Sinomenine S10-p
siRNA T3-p , K4-m2 , T6-p , K9-m2 , S10-p , T11-p , K14-ac , R17-me , K18-ac , K23-ac , K27-ac , K36-m3 , Y41-p , K56-ac , K79-m2
SKF81297 S10-p , K14-ac
SKF86002 S10-p
sorbitol S10-p , S28-p
SP600125 K9-ac , S10-p , K14-ac
staurosporine K4-m1 , K9-m2 , K27-m3 , T45-p
taxol S10-p
tazemetostat K27-m3
TG101209 K9-m3 , Y41-p
TGF-beta K4-ac , K9-ac , K27-m1 , K56-ac , K122-ac
thapsigargin S10-p
thiamet-G R17-m2
thrombin K9-m3 , K27-m3
thymidine S10-p , K56-ac
TMZ K9-ac , K14-ac
TNF K4-m1 , K9-me , S10-p , K14-ac , K27-ac
Trametinib K4-m3 , K9-m3 , K27-m3
trichostatin_A K4-m3 , K9-m3 , S10-p , K14-ac , K18-ac , K23-ac , K27-m2 , S28-p , K56-ac , K79-m2
troglitazone K9-ac , S10-p , K79-m1
U46619 T11-p
UK5099 K9-ac
ultrafast DnaE split inteins K27-m3
UNC0638 K4-m1 , K9-ac , K27-m3
UNC1999 K4-m1 , K9-m2 , K27-m3
UV R2-m2 , K9-ac , S10-p , T11-p , K14-ac , K18-ac , S28-p , T45-p , K56-ac
valproic acid K4-ac , K9-ac , K14-ac , K18-ac , K27-ac
vanadate S10-p , K14-ac
VE-821 S10-p
vemurafenib K9-me , K14-ac , K18-ac , K23-ac , K27-m3 , K36-m2
virus infection S10-p
vorinostat K4-m3 , K9-m3 , S10-p , K14-ac , K18-ac , K23-ac , K27-m3 , K56-ac , K79-ac , K122-ac
VX-680 S10-p
wortmannin K9-ac , K56-ac
Z-VAD-FMK S10-p
ZK-Thiazolidinone S28-p
ZM447439 T3-p , K9-m1 , S10-p , S28-p , K79-m3 , T80-p
zymosan K9-ac