Kinase, in vitro: 

An enzyme-substrate reaction that occurs in non-living experimental conditions such as a test tube. For example, a purified enzyme is reacted with a substrate protein or mixture of proteins or peptides.

Ack Y176-p
Akt1 S473-p
Akt1 S473-p
ERK1 T308-p
ILK S473-p
mTOR T308-p , S473-p
P38A T308-p , S473-p
PAK4 S473-p
PDK1 T308-p
PDK1 T308-p
PIK3C2A S473-p
PIK3CA T308-p
PKCB S473-p
Src iso1 Y315-p , Y326-p
 Putative in vivo kinases: 

An enzyme-substrate reaction that occurs within living cells; includes cultured cells, ex vivo samples, and intact organisms. In the case of kinases, the large number of protein kinases in intact cells makes exact identification of the responsible kinase challenging.

Ack Y176-p
Akt1 S473-p
mTOR T308-p , S473-p
mTOR S473-p
Notch 2 T308-p , S473-p
PAK4 S473-p
PDK1 T308-p
PDK1 T308-p
PKCA S473-p
Src iso1 Y315-p , Y326-p
TBK1 T308-p , S473-p
Phosphatases, in vitro:
PHLPP2 S473-p
PHLPP S473-p
PPP2CA T308-p , S473-p
PPP2CA T308-p , S473-p
PTEN S473-p
PTEN T308-p , S473-p
Putative upstream phosphatases:
PPP2CA T308-p
PTPRB Y315-p , Y326-p
Regulatory protein:
14-3-3 zeta T308-p , S473-p
ABCB10 S473-p
ACVR2B S473-p
adiponectin S473-p
ADRB1 S473-p
AKAP1 S473-p
Akt1 S473-p
Akt1 S473-p
Akt2 T308-p , S473-p
Akt3 T308-p , S473-p
ALK S473-p
AML2 T308-p , S473-p
AMPKA1 T308-p , S473-p
AMPKA2 T308-p , S473-p
AMPKA2 S473-p
APPBP2 S473-p
APPL2 S473-p
APPL T308-p , S473-p
APP S473-p
AREG S473-p
ARRB1 S473-p
AS160 S473-p
ASK1 T308-p
ASK1 T308-p
ATF6A S473-p
ATG5 T308-p , S473-p
ATG7 S473-p
BAFF S473-p
BAG1 T308-p , S473-p
BAG4 T308-p , S473-p
BCAP T308-p , S473-p
BCR-ABL1 S473-p
BIRC4BP T308-p , S473-p
BRCA1 S473-p
BRCA2 S473-p
Brk T308-p , S473-p
Btk S473-p
C3aR S473-p
C5aR S473-p
Calnexin S473-p
CAMKK1 T308-p
CASP1 S473-p
caveolin-1 T308-p , S473-p
CBFB T308-p , S473-p
Cbl-b T308-p , S473-p
CBL S473-p
CBP T308-p , S473-p
CD151 S473-p
CD19 T308-p , S473-p
CD248 S473-p
CD37 S473-p
CDC42 iso1 T308-p
CDC42 iso1 S473-p
CDH1 T308-p , S473-p
CDH2 S473-p
CDK5R1 S473-p
CDK5 S473-p
CDKL5 S473-p
CEP55 S473-p
CIDEC S473-p
CKM T308-p , S473-p
CLK2 T308-p , S473-p
CMIP S473-p
coronin 1A S473-p
CREB3L3 S473-p
CTH S473-p
CTU2 S473-p
CXCL12 S473-p
CXCL13 S473-p
CYP4F22 S473-p
DICER1 T308-p , S473-p
DKK3 T308-p , S473-p
DLK2 S473-p
DNAPK T308-p , S473-p
DRP1 T308-p , S473-p
dystrophin S473-p
EGFR T308-p , S473-p
EIF4E S473-p
ELP3 S473-p
ERK5 T308-p , S473-p
F2RL1 S473-p
FAK S473-p
FAM105B S473-p
FGFR1 S473-p
FGFR4 T308-p , S473-p
FOXM1 T308-p
FOXO1A T308-p , S473-p
FOXO1A T308-p , S473-p
Fyn S473-p
G-alpha(s) S473-p
GAB1 S473-p
GAB2 S473-p
GADD34 S473-p
GCN2 S473-p
GGPS1 S473-p
GILZ T308-p , S473-p
GLRX1 S473-p
Gm364 T308-p , S473-p
GPM6A S473-p
GPX1 T308-p , S473-p
GRB10 T308-p , S473-p
GRB10 S473-p
HDAC6 T308-p , S473-p
HER3 T308-p , S473-p
Huntingtin S473-p
ICAM1 T308-p
ICMT S473-p
IFI16 S473-p
IFITM3 S473-p
IFITM3 S473-p
IGF1R S473-p
IGF2BP2 T308-p , S473-p
IKKA S473-p
IKKA S473-p
IKKB S473-p
IKKG S473-p
IKKG S473-p
IL6R T308-p , S473-p
IL8RA S473-p
IL8RB S473-p
ILK T308-p , S473-p
ILK T308-p , S473-p
INPP5B T308-p , S473-p
IRF3 S473-p
IRS1 S473-p
IRS1 T308-p , S473-p
IRS2 T308-p , S473-p
IRS2 S473-p
IRX3 S473-p
ITGA9 S473-p
ITGB1 T308-p , S473-p
ITGB1 S473-p
ITGB3 S473-p
ITGB3 S122-p , S129-p
JAK2 S473-p
JIP1 S473-p
JNK1 T308-p , S473-p
JNK2 S473-p
K17 T308-p , S473-p
KOR-1 S473-p
KRas S473-p
KRas S473-p
LAB S473-p
laforin S473-p
LAMTOR1 S473-p
LAMTOR2 S473-p
LEF-1 S473-p
LIMS1 T308-p , S473-p
LIMS1 T308-p , S473-p
LIN28A T308-p , S473-p
LIN28B S473-p
LKB1 S473-p
LPIN1 S473-p
LST8 S473-p
LYN S473-p
LYN T308-p , S473-p
MARCH3 S473-p
MCF2 T308-p
MEK5 T308-p , S473-p
MEKK4 T308-p , S473-p
METRNL S473-p
METTL3 T308-p , S473-p
Met S473-p
Met T308-p , S473-p
Mnk1 S473-p
Mnk2 S473-p
MPC1 T308-p
MT1 S473-p
mTOR T308-p , S473-p
mTOR T308-p , S473-p
Musashi-1 T308-p , S473-p
MYD88 S473-p
N-CoR1 S473-p
NF1 S473-p
NFkB-p100 T308-p , S473-p
NFkB-p65 S473-p
NLRP3 S473-p
nNOS S473-p
NOX4 S473-p
NPM1 S473-p
NRas S473-p
NYAP2 S473-p
OCRL T308-p , S473-p
P38A S473-p
p53 S473-p
p70S6K T308-p , S473-p
PAG S473-p
PAK4 T308-p
PCYT2 S473-p
PD-L1 S473-p
PDGFRA T308-p , S473-p
PDGFRA S473-p
PDHK4 T308-p
PDK1 T308-p , S473-p
PDK1 T308-p , S473-p
perilipin 5 S473-p
PERK S473-p
PGGT1B S473-p
PGGT1B T308-p , S473-p
PHB T308-p , S473-p
PIK3C2A S473-p
PIK3CA T308-p , S473-p
PIK3CG T308-p , S473-p
PIK3R1 T308-p
PIK3R1 S473-p
PIKFYVE S473-p
PIKFYVE S473-p
Pim1 S473-p
PKCA S473-p
PKCA S473-p
PKCD S473-p
PKCE S473-p
PKCI T308-p , S473-p
PKCT T308-p , S473-p
PKDCC S473-p
PKR S473-p
PLCB2 T308-p , S473-p
PPM1K S473-p
PPP1CA S473-p
PPP1CC S473-p
PPP2CA T308-p
PPP2CA T308-p
PPP2CB T308-p
PPP2R1B S473-p
PPP2R5B T308-p , S473-p
PPP2R5B T308-p , S473-p
PPP5C T308-p
Prl2a1 S473-p
PSEN1 S473-p
PTEN T308-p , S473-p
PTEN T308-p , S473-p
PTGER3 S473-p
PTGER4 S473-p
PTN T308-p , S473-p
PTPRZ1 T308-p , S473-p
PYCARD S473-p
RABGGTA S473-p
RAC1 T308-p
RAP1B T308-p
Raptor T308-p , S473-p
Raptor T308-p , S473-p
RASAL2 S473-p
RBPJ S473-p
Rb S473-p
Ret S473-p
RHEB T308-p , S473-p
RHOA T308-p
RhoGDI alpha T308-p , S473-p
RIC8B S473-p
RICTOR T308-p , T450-p , S473-p
RICTOR T308-p , T450-p , S473-p
RNF31 S473-p
ROCK1 T308-p , S473-p
SCD T308-p , S473-p
SESN2 T308-p , S473-p
SGK1 S473-p
SGK1 T308-p , S473-p
SH3BP2 T308-p , S473-p
SHARPIN S473-p
SHC1 S473-p
SHIP T308-p
SHP-2 S473-p
SHP-2 T308-p , S473-p
SHPS1 S473-p
SIGLEC7 T308-p , S473-p
SIK S473-p
Sin1 S473-p
Sin1 T308-p , T450-p , S473-p
SIRT1 S473-p
SIRT1 S473-p
SIRT7 S473-p
SIRT7 S473-p
SMO T308-p , S473-p
SPHK1 S473-p
Src S473-p
SRR T308-p , S473-p
STAT3 S473-p
SYAP1 S473-p
Syk S473-p
Syk S473-p
syndecan-4 T308-p , S473-p
TBK1 S473-p
TBK1 T308-p , S473-p
TCF7 S473-p
TCL1A T308-p , S473-p
TDGF1 S473-p
TMCC3 T308-p , S473-p
TMEM55B T308-p , S473-p
TNFAIP8 S473-p
TNFRSF18 T308-p
TORC2 S473-p
TRAF3 T308-p
TRB2 T308-p , S473-p
TREM2 S473-p
TSC1 T308-p , S473-p
TSC2 S473-p
TSC2 T308-p , S473-p
TTC3 T308-p , S473-p
UBC9 T308-p , S473-p
UBXN2A S473-p
VAV3 S473-p
VEGF iso1 S473-p
WDR24 T308-p , S473-p
WWTR1 S473-p
XIAP T308-p
ZAP70 T308-p , S473-p
ZBTB7B T308-p , S473-p
Treatment:
L-NPA S473-p
#11a S473-p
1-butanol S473-p
3-PEHPC S473-p
4-HT S473-p
8,8'-bieckol S473-p
8-(3-chlorostyryl) caffeine S473-p
8-Rp-cAMP S473-p
A-443654 S473-p
acadesine T308-p , S473-p
acetic acid T308-p , S473-p
ACh S473-p
actinomycin_D S473-p
activin T308-p , S473-p
adiponectin T308-p , S473-p
ADP S473-p
adriamycin S473-p
AG1295 S473-p
AG1433 S473-p
AG1478 S473-p
Akt-I-1 S473-p
Akt-I-1,2 T308-p
Akt_activator_compound_11 S473-p
Akt_inhibitor_VIII T308-p , S473-p
Akt_inhibitor_X S473-p
alloxan S473-p
alloxazine S473-p
alpelisib T308-p , S473-p
alpha-lipoic_acid S473-p
alpha-mangostin T308-p
AM251 T308-p , S473-p
amino_acid_starvation S473-p
amino_acids T308-p , S473-p
amlexanox S473-p
angiopoietin-1 S473-p
angiopoietin-2 S473-p
angiotensin_2 S473-p
antibody T308-p , S473-p
apomorphine T308-p
apyrase S473-p
arsenite S473-p
AS252424 T308-p , S473-p
atorvastatin T308-p , S473-p
ATP S473-p
axatomy T308-p , S473-p
AZD8055 S473-p
bacterial infection T308-p , S473-p
BAPTA-AM T308-p , S473-p
BDNF T308-p , S473-gl
BI-D1870 S473-p
bicuculline S473-p
bisindolylmaleimide S473-p
blood pressure S473-p
BLU9931 T308-p , S473-p
BMP2 S126-p
BMS-536924 S473-p
branched-chain amino acids deprivation S473-p , Y474-p
BRD0705 S473-p
bromocriptine S473-p
butaprost T308-p , S473-p
butein S473-p
BX795 T308-p , T450-p , S473-p
BX912 T308-p , S473-p
C3aR_antagonist S473-p
C5aR_antagonist S473-p
calphostin_C T308-p , S473-p
calyculin_A T308-p , S473-p
canertinib S473-p
cangrelor T308-p , S473-p
carboplatin T308-p , S473-p
CAS_227449-73-2 S473-p
castration S473-p
catalase T308-p , S473-p
CC260 T308-p , S473-p
cell_adhesion S473-p
cetuximab S473-p
CF3CN S473-p
CGRP T308-p , S473-p
CHIR99021 T308-p , S473-p
chloroquine S473-p
cholera_toxin T308-p
chronic unpredictable stress S473-p
ciclopirox_olamine S473-p
cilengitide S473-p
cisplatin S473-p
CL316,243 S473-p
clodronic_acid S473-p
clonidine S473-p
cocaine T308-p
cold_water_stress S473-p
colforsin T308-p , S473-p
collagen S473-p
Collagen related peptide S473-p
compound_C T308-p , S473-p
ConA S473-p
conditioned medium S473-p
contextual fear conditioning S473-gl
copanlisib T308-p , S473-p
cpd22 S473-p
CRP S473-p
culturing_of_cells T308-p , S473-p
CXCL12 S473-p
CXCL5 S473-p
CXCL8 S473-p
Cyasterone S473-p
cyclic_stretch S473-p
cycloheximide T450-p , S473-p
cysteine T308-p , S473-p
dabrafenib S473-p
dactolisib T308-p , S473-p
DEN S473-p
Dendrobium officinale polysaccharide T308-p , S473-p
deoxygenation S473-p
development T308-p , S473-p
dexamethasone S473-p
DI-PHPB S473-p
dieckol S473-p
DNP S473-p
doconexent T308-p , S473-p
DPCPX S473-p
Dynasore S473-p
eckol S473-p
EDTA S473-p
EGF T308-p , Y315-p , Y326-p , S473-p
EGTA S473-p
eplerenone S473-p
Epo T308-p , S473-p
estradiol T308-p , S473-p
ethanol S473-p
ether S473-p
etoposide S473-p
exercise T308-p , S473-p , Y474-p
exercise training T308-p , S473-p
faslodex S473-p
fasting T308-p , S473-p
FGF1 T308-p
FGF2 T308-p , S473-p
fibrinogen T308-p , S473-p
fibronectin S473-p
fingolimod S473-p
fluoxetine S473-p
fMLP T308-p , S473-p
food deprivation S473-p
fostriecin T308-p , S473-p
free_fatty_acids S473-p
G-CSF S473-p
GAB-001 S473-p
GAB-004 S473-p
GDNF T308-p , S473-p
gefitinib S473-p
genistein S473-p
geranylgeranyl pyrophosphate S473-p
GF109203X T308-p , S473-p
GGTI-298 S473-p
glucosamine S473-p
glucose T308-p , S473-p
glucose_starvation S473-p
glycine S473-p
GM-CSF T308-p , S473-p
Go_6976 T308-p , S473-p
growth factor stimulation T308-p , S473-p
GSK2334470 T308-p , S473-p
guanosine S473-p
GYY4137 S473-p
H-89 S473-p
H-CHO S473-p
H2O2 T308-p , S473-p
haloperidol T308-p , S473-p
HC-5404 S473-p
heating S473-p
herstatin S473-p
HGF S473-p
high-fat diet T308-p , S473-p
high_cell_density T308-p , S473-p
high_glucose T308-p , S473-p
honokiol S473-p
HU-210 T308-p , S473-p
HY-10249A S473-p
hypertension S473-p
hypoxia T308-p , S473-p
hypoxia/reoxygenation T308-p , T450-p , S473-p
IBMX T308-p , S473-p
ibrutinib S473-p
IC87114 T308-p , S473-p
ICAM-1 S473-p
icatibant S473-p
idelalisib T308-p
IDRX-42 S473-p
ifenprodil T308-p , S473-p
IFN-gamma S473-p
IgE T308-p , S473-p
IGF-1 T308-p , T450-p , S473-p
IGF-2 T308-p , S473-p
IGFBP-4 S473-p
IL-10 S473-p
IL-13 S473-p
IL-15 S473-p
IL-1b S473-p
IL-2 T308-p , S473-p
IL-21 S473-p
IL-22 T308-p
IL-3 S473-p
IL-4 S473-p
IL-6 T308-p , S473-p
IL-7 T308-p , S473-p
imatinib S473-p
inflammation T308-p , S473-p
INK-128 S473-p
insulin T308-p , T450-p , S473-p , S477-p , T479-p
ionizing_radiation T308-p , S473-p
ionomycin S473-p
ipatasertib T308-p
ischemia T308-p , T450-p , S473-p
ischemia/reperfusion T450-p , S473-p
isoflurane S473-p
isoproterenol S473-p
JAK_inhibitor_I S473-p
Jatrorrhizine S473-p
JNK_inhibitor_I S473-p
ketamine S473-p
KGF S473-p
KirA6 S473-p
KN-62 T308-p
KP-392 S473-p
KU-0063794 T308-p , S473-p
L-lactate S473-p
L-mevalonate S473-p
L803-mts T308-p
laminar flow T308-p , S473-p
lapatinib T308-p , S473-p
latrunculin_A S473-p
let-7 miRNA S473-p
leucine S473-p
levamfetamine T308-p , S473-p
LG268 S473-p
LIF T308-p , S473-p
LIF withdrawal S473-p
linoleic_acid T308-p
linsitinib S473-p
lithium S473-p
long-chain polyphosphates T308-p
long-term_potentiation T308-p , S473-p
low-fat diet S473-p
low_cell_density T308-p
low_glucose S473-p
low_temperature S473-p
LPA T308-p , S473-p
LPS T308-p , S473-p
lupeol T308-p
LY294002 T308-p , Y315-p , Y326-p , S473-p , S477-p
M-CSF T308-p , S473-p
magnetic_field,_coherent T308-p , S473-p
meal feeding T308-p , S473-p
mechanical stress T308-p , S473-p
memantine T308-p , S473-p
metamfetamine T308-p , S473-p
metformin S473-p
methotrexate S473-p
methyl-beta-cyclodextrin T308-p , S473-p
MG132 S473-p
miR-143 T308-p , S473-p
miRNA T308-p , T450-p , S473-p
MK-2206 T308-p , S473-p , T479-p
MK801 S473-p
MMS S473-p
Mn(2+) S473-p
MPTP S473-p
MRS-1523 S473-p
muscle contraction T308-p
mutation S473-p
myocardial infarction S473-p
myostatin S473-p
N-cadherin S473-p
NAC T308-p , S473-p
NBD_peptide S473-p
nerve_damage S473-p
neuregulin T308-p , S473-p
neurotensin T308-p
NGF S473-p
Ni(2+) S473-p
nicardipine S473-p
nitric_oxide S473-p
NKH_477 S473-p
normal chow diet T308-p
NP68 S473-p
NT157 T308-p , S473-p
nutlin-3 S473-p
NVP-AEW541 S473-p
NVP-BKM120 T308-p , S473-p
obesity-inducing diet S473-p
OGD/R S473-p
okadaic_acid T308-p , S473-p
OVA S473-p
PA S473-p
PAG S473-p
palmitate T308-p , S473-p
PAN T450-p , S473-p
PAR1-activating_peptide T308-p , S473-p
PAR4-activating_peptide T308-p , S473-p
PcActx peptide S473-p
PD0325901 S473-p
PD123319 S473-p
PD98059 T308-p , S473-p
PDGF T308-p , T450-p , S473-p
Pentadecanoic acid T308-gl , S473-p
peptidoglycan S473-p
perillyl alcohol S473-p
PF 573228 S473-p
PF-4708671 S473-p
PGE2 T308-p , S473-p
PHA-665752 S473-p
phentolamine S473-p
phorbol_ester T308-p , S473-p
physostigmine T308-p , S473-p
PI-103 S473-p
picropodophyllin S473-p
pictilisib T308-p , S473-p
PIF S473-p
PIK90 T308-p , T450-p , S473-p
pilocarpine T308-p , S473-p
PIP3 S473-p
piroxicam T308-p
pleiotrophin S473-p
PLX3397 S473-p
PLX4032 S473-p
poly(I-C) S473-p
poly-L-lysine S473-p
pomolic acid T308-p
PP1 T308-p , S473-p
PP2 T308-p , Y315-p , Y326-p , S473-p
PP242 T308-p , T450-p , S473-p
pregnancy S473-p
pressure S473-p
PRLi S473-p
progesterone T308-p
protozoan infection T308-p , S473-p
PTX T308-p , S473-p
PUGNAc T308-p
QL9_peptide T308-p
quinpirole T308-p
RAD001 S473-p
Radix Rehmanniae Praeparata S473-p
RANKL S473-p
rapamycin T308-p , T450-p , S473-p
refeeding T308-p , S473-p
resatorvid S473-p
resveratrol S473-p
RGD S473-p
RGE S473-p
rigosertib S473-p
ritonavir T308-p , S473-p
RMC-6272 S473-p
rosiglitazone S473-p
rottlerin S473-p
SB202190 T308-p , S473-p
SB203580 T308-p , S473-p
SBI-0206965 T308-p , S473-p
SCF S473-p
serum T308-p , T450-p , S473-p
serum_starvation T308-p , S473-p
serum_withdrawal T308-p , S473-p
Shh S473-p
SHP099 S473-p
silmitasertib S129-p
simvastatin S473-p
siRNA T308-p , S473-p
SKF38393 T308-p
skin aging T308-p , S473-p
SN-50 S473-p
SP600125 T308-p , T450-p , S473-p
sphingomyelinase T308-p , S473-p
sphingosine_1-phosphate T308-p , S473-p
SPT S473-p
SR48527 T308-p
SR49711 T308-p
SRT2104 S473-p
starvation S473-p
starvation_medium S473-p
staurosporine T308-p , S473-p
streptozotocin S473-p
SU5402 S473-p
SU6656 S473-p
sulforaphane S473-p
sulprostone T308-p , S473-p
sVCAM-1 S473-p
t-butanol S473-p
tamoxifen S473-p
TGF-alpha S473-p
TGF-beta T308-p , S473-p
thapsigargin S473-p
Theophylline T308-p , S473-p
thrombin T308-p , S473-p
TNF T308-p , S473-p
Toluidine blue O S473-p
topotecan S473-p
Torin1 T308-p , T450-p , S473-p
TPCK S473-p
trastuzumab S473-p
triciribine T308-p , S473-p
troglitazone T308-p , S473-p
tucatinib S473-p
TUG-891 S473-p
tunicamycin S473-p
U0126 T308-p , S473-p
UV T308-p , S473-p
UVB T308-p , S473-p
vanadate T308-p , S473-p
VAT-R T308-p , S473-p
VEGF S473-p
vemurafenib S473-p
VIIa S473-p
Visudyne S473-p
vitronectin S473-p
VPS34-IN1 T308-p , S473-p
Weigela florida T308-p , S473-p
WIN S473-p
Wnt S473-p
Wnt3a S473-p
wortmannin T308-p , S473-p
XL-147 S473-p
Y27632 T308-p
YM-254890 S473-p