Kinase, in vitro: 

An enzyme-substrate reaction that occurs in non-living experimental conditions such as a test tube. For example, a purified enzyme is reacted with a substrate protein or mixture of proteins or peptides.

IRAK4 T342-p , T345-p , S346-p
 Putative in vivo kinases: 

An enzyme-substrate reaction that occurs within living cells; includes cultured cells, ex vivo samples, and intact organisms. In the case of kinases, the large number of protein kinases in intact cells makes exact identification of the responsible kinase challenging.

IRAK4 T6-p , S8-p , S114-p , S150-p , S151-p , S152-p , T208-p , T209-p , T342-p , T345-p , S346-p , T352-p
Treatment:
compound_1 T345-p , S346-p
IL-1b T345-p , S346-p