|
R5-m1
|
___MTERrVPFsLLr
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
___MTERrVPFsLLr
|
R5-m1
|
|
HSP27 (mouse)
|
___MTERRVPFsLLr
|
R5
|
|
HSP27 (rat)
|
___MTERRVPFsLLR
|
R5
|
|
HSP27 (pig)
|
___MTERRVPFSLLR
|
R5
|
|
HSP27 (hamster)
|
___MTERRVPFSLLR
|
R5
|
|
HSP27 (chicken)
|
___MAERRVPFTFLT
|
R5
|
|
HSP27 (dog)
|
___MTERRVPFSLLR
|
R5
|
|
HSP27 (cow)
|
___MAERRVPFSLLR
|
R5
|
|
|
S9-p
|
TERrVPFsLLrGPsW
|
|
|
1
|
8
|
|
|
HSP27 (human)
|
TERrVPFsLLrGPsW
|
S9-p
|
|
HSP27 (mouse)
|
TERRVPFsLLrsPsW
|
S9-p
|
|
HSP27 (rat)
|
TERRVPFsLLRsPsW
|
S9-p
|
|
HSP27 (pig)
|
TERRVPFSLLRSPSW
|
S9
|
|
HSP27 (hamster)
|
TERRVPFSLLRSPsW
|
S9
|
|
HSP27 (chicken)
|
AERRVPFTFLTSPsW
|
T9
|
|
HSP27 (dog)
|
TERRVPFSLLRSPsW
|
S9
|
|
HSP27 (cow)
|
AERRVPFSLLRGPSW
|
S9
|
|
|
R12-m1
|
rVPFsLLrGPsWDPF
|
|
|
0
|
36
|
|
|
HSP27 (human)
|
rVPFsLLrGPsWDPF
|
R12-m1
|
|
HSP27 (mouse)
|
RVPFsLLrsPsWEPF
|
R12-m1
|
|
HSP27 (rat)
|
RVPFsLLRsPsWEPF
|
R12
|
|
HSP27 (pig)
|
RVPFSLLRSPSWDPF
|
R12
|
|
HSP27 (hamster)
|
RVPFSLLRSPsWEPF
|
R12
|
|
HSP27 (chicken)
|
RVPFTFLTSPsWEPF
|
T12
|
|
HSP27 (dog)
|
RVPFSLLRSPsWDPF
|
R12
|
|
HSP27 (cow)
|
RVPFSLLRGPSWDPF
|
R12
|
|
|
G13
|
VPFsLLrGPsWDPFr
|
|
|
0
|
7
|
|
|
HSP27 (human)
|
VPFsLLrGPsWDPFr
|
G13
|
|
HSP27 (mouse)
|
VPFsLLrsPsWEPFR
|
S13-p
|
|
HSP27 (rat)
|
VPFsLLRsPsWEPFR
|
S13-p
|
|
HSP27 (pig)
|
VPFSLLRSPSWDPFR
|
S13
|
|
HSP27 (hamster)
|
VPFSLLRSPsWEPFR
|
S13
|
|
HSP27 (chicken)
|
VPFTFLTSPsWEPFR
|
S13
|
|
HSP27 (dog)
|
VPFSLLRSPsWDPFR
|
S13
|
|
HSP27 (cow)
|
VPFSLLRGPSWDPFR
|
G13
|
|
|
S15-p
|
FsLLrGPsWDPFrDW
|
Upstream
|
Downstream
|
43
|
108
|
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
- phosphorylation
- protein conformation
- protein degradation
- protein stabilization
- sumoylation
|
|
Effects on Biological Processes:
- apoptosis, altered
- apoptosis, inhibited
- cell growth, altered
- cytoskeletal reorganization
- signaling pathway regulation
- transcription, altered
- transcription, inhibited
|
|
|
Kinase, in vitro:
- MAPKAPK2 (human)
- PKG1 iso2 (human)
|
|
Putative in vivo kinases:
|
|
Regulatory protein:
- FAM83G (human)
- MAPKAPK3 (human)
- P38A (no information)
|
|
Treatment
- adriamycin
- ADT
- arsenite
- bacterial infection
- cisplatin
- D3T
- dasatinib
- EGF
- fluorouracil
- histamine
- IL-1b
- ischemia
- J2
- lapatinib
- LRRK2-IN-1
- menadione
- MG132_withdrawal
- MK2-I
- mutation
- OSU-03012
- PAR1-activating_peptide
- PF3644022
- SB202190
- SB203580
- siRNA
- thiolutin
- thrombin
- U0126
- vorapaxar
- ZK-Thiazolidinone
|
|
|
HSP27 (human)
|
FsLLrGPsWDPFrDW
|
S15-p
|
|
HSP27 (mouse)
|
FsLLrsPsWEPFRDW
|
S15-p
|
|
HSP27 (rat)
|
FsLLRsPsWEPFRDW
|
S15-p
|
|
HSP27 (pig)
|
FSLLRSPSWDPFRDW
|
S15
|
|
HSP27 (hamster)
|
FSLLRSPsWEPFRDW
|
S15-p
|
|
HSP27 (chicken)
|
FTFLTSPsWEPFRDW
|
S15-p
|
|
HSP27 (dog)
|
FSLLRSPsWDPFRDW
|
S15-p
|
|
HSP27 (cow)
|
FSLLRGPSWDPFRDW
|
S15
|
|
|
R20-m1
|
GPsWDPFrDWyPHsR
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
GPsWDPFrDWyPHsR
|
R20-m1
|
|
HSP27 (mouse)
|
sPsWEPFRDWYPAHS
|
R20
|
|
HSP27 (rat)
|
sPsWEPFRDWYPAHs
|
R20
|
|
HSP27 (pig)
|
SPSWDPFRDWYPAHS
|
R20
|
|
HSP27 (hamster)
|
SPsWEPFRDWYPAHS
|
R20
|
|
HSP27 (chicken)
|
SPsWEPFRDWYHGSR
|
R20
|
|
HSP27 (dog)
|
SPsWDPFRDWYPAHS
|
R20
|
|
HSP27 (cow)
|
GPSWDPFRDWYPAHS
|
R20
|
|
|
Y23-p
|
WDPFrDWyPHsRLFD
|
|
|
0
|
13
|
|
|
HSP27 (human)
|
WDPFrDWyPHsRLFD
|
Y23-p
|
|
HSP27 (mouse)
|
WEPFRDWYPAHSRLF
|
Y23
|
|
HSP27 (rat)
|
WEPFRDWYPAHsRLF
|
Y23
|
|
HSP27 (pig)
|
WDPFRDWYPAHSRLF
|
Y23
|
|
HSP27 (hamster)
|
WEPFRDWYPAHSRLF
|
Y23
|
|
HSP27 (chicken)
|
WEPFRDWYHGSRLFD
|
Y23
|
|
HSP27 (dog)
|
WDPFRDWYPAHSRLF
|
Y23
|
|
HSP27 (cow)
|
WDPFRDWYPAHSRLF
|
Y23
|
|
|
S26-p
|
FrDWyPHsRLFDQAF
|
|
|
0
|
3
|
|
|
HSP27 (human)
|
FrDWyPHsRLFDQAF
|
S26-p
|
|
HSP27 (mouse)
|
RDWYPAHSRLFDQAF
|
S27
|
|
HSP27 (rat)
|
RDWYPAHsRLFDQAF
|
S27-p
|
|
HSP27 (pig)
|
RDWYPAHSRLFDQAF
|
S27
|
|
HSP27 (hamster)
|
RDWYPAHSRLFDQAF
|
S27
|
|
HSP27 (chicken)
|
FRDWYHGSRLFDQSF
|
S26
|
|
HSP27 (dog)
|
RDWYPAHSRLFDQAF
|
S27
|
|
HSP27 (cow)
|
RDWYPAHSRLFDQAF
|
S27
|
|
|
R37-m1
|
DQAFGLPrLPEEWSQ
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
DQAFGLPrLPEEWSQ
|
R37-m1
|
|
HSP27 (mouse)
|
DQAFGVPRLPDEWSQ
|
R38
|
|
HSP27 (rat)
|
DQAFGVPrFPDEWSQ
|
R38-m1
|
|
HSP27 (pig)
|
DQAFGLPRLPEEWSQ
|
R38
|
|
HSP27 (hamster)
|
DQAFGVPRLPDEWSQ
|
R38
|
|
HSP27 (chicken)
|
DQSFGMPHIPEDWYK
|
H37
|
|
HSP27 (dog)
|
DQAFGLPRLPEEWAQ
|
R38
|
|
HSP27 (cow)
|
DQAFGLPRLPEEWSQ
|
R38
|
|
|
Y54-p
|
GGSSWPGyVrPLPPA
|
|
|
0
|
4
|
|
|
HSP27 (human)
|
GGSSWPGyVrPLPPA
|
Y54-p
|
|
HSP27 (mouse)
|
SAAGWPGYVRPLPAA
|
Y55
|
|
HSP27 (rat)
|
SSAGWPGYVRPLPAA
|
Y55
|
|
HSP27 (pig)
|
SHSGWPGYVRPLPPP
|
Y55
|
|
HSP27 (hamster)
|
SAAGWPGYVRPLPAA
|
Y55
|
|
HSP27 (chicken)
|
SGSAWPGYFRLLPSE
|
Y54
|
|
HSP27 (dog)
|
GHSGWPGYVRPIPPA
|
Y55
|
|
HSP27 (cow)
|
SHSGWPGYVRALPAA
|
Y55
|
|
|
R56-m1
|
SSWPGyVrPLPPAAI
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
SSWPGyVrPLPPAAI
|
R56-m1
|
|
HSP27 (mouse)
|
AGWPGYVRPLPAATA
|
R57
|
|
HSP27 (rat)
|
AGWPGYVRPLPAATA
|
R57
|
|
HSP27 (pig)
|
SGWPGYVRPLPPPAI
|
R57
|
|
HSP27 (hamster)
|
AGWPGYVRPLPAATA
|
R57
|
|
HSP27 (chicken)
|
SAWPGYFRLLPSESA
|
R56
|
|
HSP27 (dog)
|
SGWPGYVRPIPPAVE
|
R57
|
|
HSP27 (cow)
|
SGWPGYVRALPAAAI
|
R57
|
|
|
S65-p
|
LPPAAIEsPAVAAPA
|
Upstream
|
|
0
|
22
|
|
|
Treatment
- LRRK2-IN-1
- nocodazole
- selumetinib
- vemurafenib
- ZK-Thiazolidinone
|
|
|
HSP27 (human)
|
LPPAAIEsPAVAAPA
|
S65-p
|
|
HSP27 (mouse)
|
LPAATAEGPAAVtLA
|
G66
|
|
HSP27 (rat)
|
LPAATAEGPAAVTLA
|
G66
|
|
HSP27 (pig)
|
LPPPAIEGPAAVAAP
|
G66
|
|
HSP27 (hamster)
|
LPAATAEGPAAVALA
|
G66
|
|
HSP27 (chicken)
|
GYFRLLPSESALLPA
|
S60
|
|
HSP27 (dog)
|
PIPPAVEGPAAAAAA
|
G65
|
|
HSP27 (cow)
|
gap
|
-
|
|
|
A67
|
PAAIEsPAVAAPAys
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
PAAIEsPAVAAPAys
|
A67
|
|
HSP27 (mouse)
|
AEGPAAVtLAAPAFs
|
T71-p
|
|
HSP27 (rat)
|
AEGPAAVTLARPAFS
|
T71
|
|
HSP27 (pig)
|
gap
|
-
|
|
HSP27 (hamster)
|
AEGPAAVALAAPLAA
|
A71
|
|
HSP27 (chicken)
|
LPSESALLPAPGSPY
|
L65
|
|
HSP27 (dog)
|
VEGPAAAAAAAAPAY
|
A70
|
|
HSP27 (cow)
|
gap
|
-
|
|
|
Y73-p
|
PAVAAPAysRALsRQ
|
|
|
0
|
13
|
|
|
HSP27 (human)
|
PAVAAPAysRALsRQ
|
Y73-p
|
|
HSP27 (mouse)
|
VtLAAPAFsRALNRQ
|
F77
|
|
HSP27 (rat)
|
VTLARPAFSRALNRQ
|
F77
|
|
HSP27 (pig)
|
AAVAAPAYSRLLSRQ
|
Y75
|
|
HSP27 (hamster)
|
APLAAPAFHRALNRQ
|
F81
|
|
HSP27 (chicken)
|
LPAPGSPYGRALsEL
|
Y72
|
|
HSP27 (dog)
|
AAAAAPAYsRALSRQ
|
Y77
|
|
HSP27 (cow)
|
AAIEGPAYNRALSRQ
|
Y69
|
|
|
S74-p
|
AVAAPAysRALsRQL
|
|
|
1
|
5
|
|
|
HSP27 (human)
|
AVAAPAysRALsRQL
|
S74-p
|
|
HSP27 (mouse)
|
tLAAPAFsRALNRQL
|
S78-p
|
|
HSP27 (rat)
|
TLARPAFSRALNRQL
|
S78
|
|
HSP27 (pig)
|
AVAAPAYSRLLSRQL
|
S76
|
|
HSP27 (hamster)
|
PLAAPAFHRALNRQL
|
H82
|
|
HSP27 (chicken)
|
PAPGSPYGRALsELS
|
G73
|
|
HSP27 (dog)
|
AAAAPAYsRALSRQL
|
S78-p
|
|
HSP27 (cow)
|
AIEGPAYNRALSRQL
|
N70
|
|
|
S78-p
|
PAysRALsRQLssGV
|
Upstream
|
Downstream
|
32
|
55
|
|
|
|
|
Effects on Modified Protein
- activity, induced
- intracellular localization
- molecular association, regulation
- phosphorylation
- protein conformation
- protein degradation
- sumoylation
- ubiquitination
|
|
Effects on Biological Processes:
- apoptosis, altered
- apoptosis, inhibited
- carcinogenesis, induced
- cell cycle regulation
- cell growth, altered
- cell growth, induced
- cell motility, induced
- cytoskeletal reorganization
- signaling pathway regulation
- transcription, altered
- transcription, inhibited
|
|
|
Kinase, in vitro:
- MAPKAPK2 (human)
- PKACA (human)
- PKG1 iso2 (human)
|
|
Putative in vivo kinases:
- MAPKAPK2 (human)
- P70S6KB (human)
|
|
Regulatory protein:
- AR (human)
- MAPKAPK2 (human)
- MAPKAPK3 (human)
- P38A (human)
- P38A (no information)
- SMAD4 (human)
|
|
Treatment
- 5-iodotubercidin
- ACh
- adriamycin
- ADT
- ara-a
- arsenite
- bacterial infection
- Bay61-3606
- bicalutamide
- BIRB-0796
- calyculin_A
- circRNA
- cisplatin
- D3T
- diclofenac
- FGF2
- H2O2
- heat_shock
- heregulin
- histamine
- IL-1b
- J2
- menadione
- metribolone
- mutation
- nerve_damage
- nocodazole
- OSU-03012
- PAR1-activating_peptide
- PD98059
- PF3644022
- phorbol_ester
- S-diclofenac
- S-sulindac
- S-valproate
- SB202190
- SB203347
- SB203580
- serum
- siRNA
- sodium_hydrosulfide
- SP600125
- spermine-NONOate
- sulindac
- taxol
- thiolutin
- thrombin
- TNF
- valproic acid
- vorapaxar
|
|
|
HSP27 (human)
|
PAysRALsRQLssGV
|
S78-p
|
|
HSP27 (mouse)
|
PAFsRALNRQLssGV
|
N82
|
|
HSP27 (rat)
|
PAFSRALNRQLssGV
|
N82
|
|
HSP27 (pig)
|
PAYSRLLSRQLsSGV
|
S80
|
|
HSP27 (hamster)
|
PAFHRALNRQLsSGV
|
N86
|
|
HSP27 (chicken)
|
SPYGRALsELSsGIS
|
S77-p
|
|
HSP27 (dog)
|
PAYsRALSRQLsSGV
|
S82
|
|
HSP27 (cow)
|
PAYNRALSRQLsSGV
|
S74
|
|
|
S82-p
|
RALsRQLssGVsEIr
|
Upstream
|
Downstream
|
65
|
390
|
|
|
|
|
Effects on Modified Protein
- activity, induced
- intracellular localization
- molecular association, regulation
- phosphorylation
- protein conformation
- protein degradation
- sumoylation
- ubiquitination
|
|
Effects on Biological Processes:
- apoptosis, altered
- apoptosis, inhibited
- carcinogenesis, induced
- cell growth, altered
- cell growth, induced
- cell motility, induced
- cytoskeletal reorganization
- signaling pathway regulation
- transcription, altered
- transcription, inhibited
|
|
|
Kinase, in vitro:
- Akt1 (human)
- MAPKAPK2 (human)
- PKACA (human)
- PKG1 iso2 (human)
- PRKD1 (human)
|
|
Putative in vivo kinases:
- Akt1 (human)
- MAPKAPK3 (human)
- P70S6KB (human)
- PRKD1 (human)
|
|
Regulatory protein:
- ANXA1 (human)
- AR (human)
- Chk1 (human)
- CYBA (human)
- FAM83G (human)
- MAPKAPK2 (human)
- P38A (human)
- PRKD1 (human)
- SMAD4 (human)
|
|
Treatment
- ACh
- adriamycin
- ADT
- angiotensin-(1-7)
- anisomycin
- apocynin
- arsenite
- bicalutamide
- bombesin
- bryostatin_1
- circRNA
- cisplatin
- D3T
- EGF
- FGF2
- fluorouracil
- Go_6976
- H2O2
- heat_shock
- heregulin
- histamine
- IL-1b
- ionizing_radiation
- ischemia
- J2
- lapatinib
- menadione
- metastatic potential
- metribolone
- MG132_withdrawal
- microcystin-LR
- MK2-I
- mutation
- NAC
- neurotensin
- nocodazole
- OSU-03012
- PAR1-activating_peptide
- PD98059
- PF3644022
- phorbol_ester
- SB202190
- SB203347
- SB203580
- serum
- siRNA
- SP600125
- taxol
- thiolutin
- thrombin
- TNF
- U0126
- UCN-01
- UV
- vorapaxar
- WKYMVm
|
|
|
HSP27 (human)
|
RALsRQLssGVsEIr
|
S82-p
|
|
HSP27 (mouse)
|
RALNRQLssGVsEIR
|
S86-p
|
|
HSP27 (rat)
|
RALNRQLssGVsEIR
|
S86-p
|
|
HSP27 (pig)
|
RLLSRQLsSGVSEIQ
|
S84-p
|
|
HSP27 (hamster)
|
RALNRQLsSGVSEIR
|
S90-p
|
|
HSP27 (chicken)
|
GRALsELSsGISEIR
|
S80
|
|
HSP27 (dog)
|
RALSRQLsSGVSEIR
|
S86-p
|
|
HSP27 (cow)
|
RALSRQLsSGVSEIQ
|
S78-p
|
|
|
S83-p
|
ALsRQLssGVsEIrH
|
Upstream
|
Downstream
|
3
|
43
|
|
|
Effects on Biological Processes:
- cell differentiation, induced
|
|
|
Regulatory protein:
|
|
Treatment
- H2O2
- ionizing_radiation
- NaB
- T-2 toxin
|
|
|
HSP27 (human)
|
ALsRQLssGVsEIrH
|
S83-p
|
|
HSP27 (mouse)
|
ALNRQLssGVsEIRQ
|
S87-p
|
|
HSP27 (rat)
|
ALNRQLssGVsEIRQ
|
S87-p
|
|
HSP27 (pig)
|
LLSRQLsSGVSEIQQ
|
S85
|
|
HSP27 (hamster)
|
ALNRQLsSGVSEIRQ
|
S91
|
|
HSP27 (chicken)
|
RALsELSsGISEIRQ
|
S81-p
|
|
HSP27 (dog)
|
ALSRQLsSGVSEIRQ
|
S87
|
|
HSP27 (cow)
|
ALSRQLsSGVSEIQQ
|
S79
|
|
|
S86-p
|
RQLssGVsEIrHtAD
|
|
|
2
|
14
|
|
|
HSP27 (human)
|
RQLssGVsEIrHtAD
|
S86-p
|
|
HSP27 (mouse)
|
RQLssGVsEIRQTAD
|
S90-p
|
|
HSP27 (rat)
|
RQLssGVsEIRQTAD
|
S90-p
|
|
HSP27 (pig)
|
RQLsSGVSEIQQTAD
|
S88
|
|
HSP27 (hamster)
|
RQLsSGVSEIRQTAD
|
S94
|
|
HSP27 (chicken)
|
sELSsGISEIRQSAD
|
S84
|
|
HSP27 (dog)
|
RQLsSGVSEIRQTAD
|
S90
|
|
HSP27 (cow)
|
RQLsSGVSEIQQTAD
|
S82
|
|
|
R89-m1
|
ssGVsEIrHtADRWR
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
ssGVsEIrHtADRWR
|
R89-m1
|
|
HSP27 (mouse)
|
ssGVsEIRQTADRWR
|
R93
|
|
HSP27 (rat)
|
ssGVsEIRQTADRWR
|
R93
|
|
HSP27 (pig)
|
sSGVSEIQQTADRWR
|
Q91
|
|
HSP27 (hamster)
|
sSGVSEIRQTADRWR
|
R97
|
|
HSP27 (chicken)
|
SsGISEIRQSADSWK
|
R87
|
|
HSP27 (dog)
|
sSGVSEIRQTADRWR
|
R93
|
|
HSP27 (cow)
|
sSGVSEIQQTADRWR
|
Q85
|
|
|
T91-p
|
GVsEIrHtADRWRVs
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
GVsEIrHtADRWRVs
|
T91-p
|
|
HSP27 (mouse)
|
GVsEIRQTADRWRVS
|
T95
|
|
HSP27 (rat)
|
GVsEIRQTADRWRVs
|
T95
|
|
HSP27 (pig)
|
GVSEIQQTADRWRVS
|
T93
|
|
HSP27 (hamster)
|
GVSEIRQTADRWRVS
|
T99
|
|
HSP27 (chicken)
|
GISEIRQSADSWKVT
|
S89
|
|
HSP27 (dog)
|
GVSEIRQTADRWRVS
|
T95
|
|
HSP27 (cow)
|
GVSEIQQTADRWRVS
|
T87
|
|
|
S98-p
|
tADRWRVsLDVNHFA
|
|
|
0
|
9
|
|
|
HSP27 (human)
|
tADRWRVsLDVNHFA
|
S98-p
|
|
HSP27 (mouse)
|
TADRWRVSLDVNHFA
|
S102
|
|
HSP27 (rat)
|
TADRWRVsLDVNHFA
|
S102-p
|
|
HSP27 (pig)
|
TADRWRVSLDVNHFA
|
S100
|
|
HSP27 (hamster)
|
TADRWRVSLDVNHFA
|
S106
|
|
HSP27 (chicken)
|
SADSWKVTLDVNHFA
|
T96
|
|
HSP27 (dog)
|
TADRWRVSLDVNHFA
|
S102
|
|
HSP27 (cow)
|
TADRWRVSLDVNHFA
|
S94
|
|
|
K112-ub
|
APDELTVktkDGVVE
|
|
|
0
|
36
|
|
|
HSP27 (human)
|
APDELTVktkDGVVE
|
K112-ub
|
|
HSP27 (mouse)
|
APEELTVkTkEGVVE
|
K116-ub
|
|
HSP27 (rat)
|
APEELTVKtKEGVVE
|
K116
|
|
HSP27 (pig)
|
APEELTVKTKDGVVE
|
K114
|
|
HSP27 (hamster)
|
APEELTVKTKEGVVE
|
K120
|
|
HSP27 (chicken)
|
APEELVVKTKDNIVE
|
K110
|
|
HSP27 (dog)
|
APEELTVKTKDGVVE
|
K116
|
|
HSP27 (cow)
|
APEELTVKTKDGVVE
|
K108
|
|
|
T113-p
|
PDELTVktkDGVVEI
|
|
|
1
|
2
|
|
|
HSP27 (human)
|
PDELTVktkDGVVEI
|
T113-p
|
|
HSP27 (mouse)
|
PEELTVkTkEGVVEI
|
T117
|
|
HSP27 (rat)
|
PEELTVKtKEGVVEI
|
T117-p
|
|
HSP27 (pig)
|
PEELTVKTKDGVVEI
|
T115
|
|
HSP27 (hamster)
|
PEELTVKTKEGVVEI
|
T121
|
|
HSP27 (chicken)
|
PEELVVKTKDNIVEI
|
T111
|
|
HSP27 (dog)
|
PEELTVKTKDGVVEI
|
T117
|
|
HSP27 (cow)
|
PEELTVKTKDGVVEI
|
T109
|
|
|
K114-ub
|
DELTVktkDGVVEIt
|
|
|
0
|
47
|
|
|
HSP27 (human)
|
DELTVktkDGVVEIt
|
K114-ub
|
|
HSP27 (mouse)
|
EELTVkTkEGVVEIT
|
K118-ub
|
|
HSP27 (rat)
|
EELTVKtKEGVVEIT
|
K118
|
|
HSP27 (pig)
|
EELTVKTKDGVVEIT
|
K116
|
|
HSP27 (hamster)
|
EELTVKTKEGVVEIT
|
K122
|
|
HSP27 (chicken)
|
EELVVKTKDNIVEIT
|
K112
|
|
HSP27 (dog)
|
EELTVKTKDGVVEIT
|
K118
|
|
HSP27 (cow)
|
EELTVKTKDGVVEIT
|
K110
|
|
|
K114-sm
|
DELTVktkDGVVEIt
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
DELTVktkDGVVEIt
|
K114-sm
|
|
HSP27 (mouse)
|
EELTVkTKEGVVEIT
|
K118
|
|
HSP27 (rat)
|
EELTVKtKEGVVEIT
|
K118
|
|
HSP27 (pig)
|
EELTVKTKDGVVEIT
|
K116
|
|
HSP27 (hamster)
|
EELTVKTKEGVVEIT
|
K122
|
|
HSP27 (chicken)
|
EELVVKTKDNIVEIT
|
K112
|
|
HSP27 (dog)
|
EELTVKTKDGVVEIT
|
K118
|
|
HSP27 (cow)
|
EELTVKTKDGVVEIT
|
K110
|
|
|
T121-p
|
kDGVVEItGkHEERQ
|
|
|
0
|
3
|
|
|
HSP27 (human)
|
kDGVVEItGkHEERQ
|
T121-p
|
|
HSP27 (mouse)
|
kEGVVEITGKHEERQ
|
T125
|
|
HSP27 (rat)
|
KEGVVEITGkHEERQ
|
T125
|
|
HSP27 (pig)
|
KDGVVEITGKHEERQ
|
T123
|
|
HSP27 (hamster)
|
KEGVVEITGKHEERQ
|
T129
|
|
HSP27 (chicken)
|
KDNIVEITGKHEEKQ
|
T119
|
|
HSP27 (dog)
|
KDGVVEITGKHEERQ
|
T125
|
|
HSP27 (cow)
|
KDGVVEITGKHEERQ
|
T117
|
|
|
K123-ac
|
GVVEItGkHEERQDE
|
Upstream
|
|
0
|
11
|
|
|
|
|
HSP27 (human)
|
GVVEItGkHEERQDE
|
K123-ac
|
|
HSP27 (mouse)
|
GVVEITGKHEERQDE
|
K127
|
|
HSP27 (rat)
|
GVVEITGkHEERQDE
|
K127-ac
|
|
HSP27 (pig)
|
GVVEITGKHEERQDE
|
K125
|
|
HSP27 (hamster)
|
GVVEITGKHEERQDE
|
K131
|
|
HSP27 (chicken)
|
NIVEITGKHEEKQDE
|
K121
|
|
HSP27 (dog)
|
GVVEITGKHEERQDE
|
K127
|
|
HSP27 (cow)
|
GVVEITGKHEERQDE
|
K119
|
|
|
K123-ub
|
GVVEItGkHEERQDE
|
|
|
0
|
16
|
|
|
HSP27 (human)
|
GVVEItGkHEERQDE
|
K123-ub
|
|
HSP27 (mouse)
|
GVVEITGKHEERQDE
|
K127
|
|
HSP27 (rat)
|
GVVEITGKHEERQDE
|
K127
|
|
HSP27 (pig)
|
GVVEITGKHEERQDE
|
K125
|
|
HSP27 (hamster)
|
GVVEITGKHEERQDE
|
K131
|
|
HSP27 (chicken)
|
NIVEITGKHEEKQDE
|
K121
|
|
HSP27 (dog)
|
GVVEITGKHEERQDE
|
K127
|
|
HSP27 (cow)
|
GVVEITGKHEERQDE
|
K119
|
|
|
Y133-p
|
ERQDEHGyIsRCFtR
|
|
|
0
|
27
|
|
|
HSP27 (human)
|
ERQDEHGyIsRCFtR
|
Y133-p
|
|
HSP27 (mouse)
|
ERQDEHGYIsRCFTR
|
Y137
|
|
HSP27 (rat)
|
ERQDEHGYISRCFTR
|
Y137
|
|
HSP27 (pig)
|
ERQDEHGFISRCFTR
|
F135
|
|
HSP27 (hamster)
|
ERQDEHGYISRCFTR
|
Y141
|
|
HSP27 (chicken)
|
EKQDEHGFISRCFTR
|
F131
|
|
HSP27 (dog)
|
ERQDEHGYISRRLTP
|
Y137
|
|
HSP27 (cow)
|
ERQDEHGYISRCFTR
|
Y129
|
|
|
S135-p
|
QDEHGyIsRCFtRky
|
Upstream
|
|
0
|
6
|
|
|
|
|
HSP27 (human)
|
QDEHGyIsRCFtRky
|
S135-p
|
|
HSP27 (mouse)
|
QDEHGYIsRCFTRkY
|
S139-p
|
|
HSP27 (rat)
|
QDEHGYISRCFTRKY
|
S139
|
|
HSP27 (pig)
|
QDEHGFISRCFTRKY
|
S137
|
|
HSP27 (hamster)
|
QDEHGYISRCFTRKY
|
S143
|
|
HSP27 (chicken)
|
QDEHGFISRCFTRKY
|
S133
|
|
HSP27 (dog)
|
QDEHGYISRRLTPKY
|
S139
|
|
HSP27 (cow)
|
QDEHGYISRCFTRKY
|
S131
|
|
|
T139-p
|
GyIsRCFtRkytLPP
|
|
|
0
|
5
|
|
|
HSP27 (human)
|
GyIsRCFtRkytLPP
|
T139-p
|
|
HSP27 (mouse)
|
GYIsRCFTRkYtLPP
|
T143
|
|
HSP27 (rat)
|
GYISRCFTRKYtLPP
|
T143
|
|
HSP27 (pig)
|
GFISRCFTRKYTLPP
|
T141
|
|
HSP27 (hamster)
|
GYISRCFTRKYTLPP
|
T147
|
|
HSP27 (chicken)
|
GFISRCFTRKYTLPP
|
T137
|
|
HSP27 (dog)
|
GYISRRLTPKYTLPP
|
T143
|
|
HSP27 (cow)
|
GYISRCFTRKYTLPP
|
T135
|
|
|
K141-ub
|
IsRCFtRkytLPPGV
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
IsRCFtRkytLPPGV
|
K141-ub
|
|
HSP27 (mouse)
|
IsRCFTRkYtLPPGV
|
K145-ub
|
|
HSP27 (rat)
|
ISRCFTRKYtLPPGV
|
K145
|
|
HSP27 (pig)
|
ISRCFTRKYTLPPGV
|
K143
|
|
HSP27 (hamster)
|
ISRCFTRKYTLPPGV
|
K149
|
|
HSP27 (chicken)
|
ISRCFTRKYTLPPGV
|
K139
|
|
HSP27 (dog)
|
ISRRLTPKYTLPPGV
|
K145
|
|
HSP27 (cow)
|
ISRCFTRKYTLPPGV
|
K137
|
|
|
K141-ac
|
IsRCFtRkytLPPGV
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
IsRCFtRkytLPPGV
|
K141-ac
|
|
HSP27 (mouse)
|
IsRCFTRKYtLPPGV
|
K145
|
|
HSP27 (rat)
|
ISRCFTRKYtLPPGV
|
K145
|
|
HSP27 (pig)
|
ISRCFTRKYTLPPGV
|
K143
|
|
HSP27 (hamster)
|
ISRCFTRKYTLPPGV
|
K149
|
|
HSP27 (chicken)
|
ISRCFTRKYTLPPGV
|
K139
|
|
HSP27 (dog)
|
ISRRLTPKYTLPPGV
|
K145
|
|
HSP27 (cow)
|
ISRCFTRKYTLPPGV
|
K137
|
|
|
Y142-p
|
sRCFtRkytLPPGVD
|
|
|
0
|
3
|
|
|
HSP27 (human)
|
sRCFtRkytLPPGVD
|
Y142-p
|
|
HSP27 (mouse)
|
sRCFTRkYtLPPGVD
|
Y146
|
|
HSP27 (rat)
|
SRCFTRKYtLPPGVD
|
Y146
|
|
HSP27 (pig)
|
SRCFTRKYTLPPGVD
|
Y144
|
|
HSP27 (hamster)
|
SRCFTRKYTLPPGVD
|
Y150
|
|
HSP27 (chicken)
|
SRCFTRKYTLPPGVE
|
Y140
|
|
HSP27 (dog)
|
SRRLTPKYTLPPGVD
|
Y146
|
|
HSP27 (cow)
|
SRCFTRKYTLPPGVD
|
Y138
|
|
|
T143-p
|
RCFtRkytLPPGVDP
|
Upstream
|
|
1
|
15
|
|
|
Kinase, in vitro:
- PKACA (human)
- PKG1 iso2 (human)
|
|
|
HSP27 (human)
|
RCFtRkytLPPGVDP
|
T143-p
|
|
HSP27 (mouse)
|
RCFTRkYtLPPGVDP
|
T147-p
|
|
HSP27 (rat)
|
RCFTRKYtLPPGVDP
|
T147-p
|
|
HSP27 (pig)
|
RCFTRKYTLPPGVDP
|
T145
|
|
HSP27 (hamster)
|
RCFTRKYTLPPGVDP
|
T151
|
|
HSP27 (chicken)
|
RCFTRKYTLPPGVEA
|
T141
|
|
HSP27 (dog)
|
RRLTPKYTLPPGVDP
|
T147
|
|
HSP27 (cow)
|
RCFTRKYTLPPGVDP
|
T139
|
|
|
T162-p
|
SSLSPEGtLtVEAPM
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
SSLSPEGtLtVEAPM
|
T162-p
|
|
HSP27 (mouse)
|
SSLSPEGTLTVEAPL
|
T166
|
|
HSP27 (rat)
|
SSLSPEGTLTVEAPL
|
T166
|
|
HSP27 (pig)
|
SSLSPEGTLSVEAPL
|
T164
|
|
HSP27 (hamster)
|
SSLSPEGTLTVEAPL
|
T170
|
|
HSP27 (chicken)
|
SSLSPDGMLTVEAPL
|
M160
|
|
HSP27 (dog)
|
SSLSPEGTLTVEAPM
|
T166
|
|
HSP27 (cow)
|
SSLSPEGTLTVEAPL
|
T158
|
|
|
T164-p
|
LSPEGtLtVEAPMPk
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
LSPEGtLtVEAPMPk
|
T164-p
|
|
HSP27 (mouse)
|
LSPEGTLTVEAPLPK
|
T168
|
|
HSP27 (rat)
|
LSPEGTLTVEAPLPK
|
T168
|
|
HSP27 (pig)
|
LSPEGTLSVEAPLPK
|
S166
|
|
HSP27 (hamster)
|
LSPEGTLTVEAPLPK
|
T172
|
|
HSP27 (chicken)
|
LSPDGMLTVEAPLPK
|
T162
|
|
HSP27 (dog)
|
LSPEGTLTVEAPMPK
|
T168
|
|
HSP27 (cow)
|
LSPEGTLTVEAPLPK
|
T160
|
|
|
K171-ub
|
tVEAPMPkLAtQsNE
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
tVEAPMPkLAtQsNE
|
K171-ub
|
|
HSP27 (mouse)
|
TVEAPLPKAVTQsAE
|
K175
|
|
HSP27 (rat)
|
TVEAPLPKAVTQSAE
|
K175
|
|
HSP27 (pig)
|
SVEAPLPKPATQSAE
|
K173
|
|
HSP27 (hamster)
|
TVEAPLPKTATQSAE
|
K179
|
|
HSP27 (chicken)
|
TVEAPLPKPAIQSSE
|
K169
|
|
HSP27 (dog)
|
TVEAPMPKPATQSAE
|
K175
|
|
HSP27 (cow)
|
TVEAPLPKSATQSAE
|
K167
|
|
|
T174-p
|
APMPkLAtQsNEItI
|
|
|
0
|
9
|
|
|
HSP27 (human)
|
APMPkLAtQsNEItI
|
T174-p
|
|
HSP27 (mouse)
|
APLPKAVTQsAEITI
|
T178
|
|
HSP27 (rat)
|
APLPKAVTQSAEITI
|
T178
|
|
HSP27 (pig)
|
APLPKPATQSAEITI
|
T176
|
|
HSP27 (hamster)
|
APLPKTATQSAEITI
|
T182
|
|
HSP27 (chicken)
|
APLPKPAIQSSEITI
|
I172
|
|
HSP27 (dog)
|
APMPKPATQSAEITI
|
T178
|
|
HSP27 (cow)
|
APLPKSATQSAEITI
|
T170
|
|
|
S176-p
|
MPkLAtQsNEItIPV
|
Upstream
|
|
1
|
8
|
|
|
Kinase, in vitro:
|
|
Treatment
|
|
|
HSP27 (human)
|
MPkLAtQsNEItIPV
|
S176-p
|
|
HSP27 (mouse)
|
LPKAVTQsAEITIPV
|
S180-p
|
|
HSP27 (rat)
|
LPKAVTQSAEITIPV
|
S180
|
|
HSP27 (pig)
|
LPKPATQSAEITIPV
|
S178
|
|
HSP27 (hamster)
|
LPKTATQSAEITIPV
|
S184
|
|
HSP27 (chicken)
|
LPKPAIQSSEITIPV
|
S174
|
|
HSP27 (dog)
|
MPKPATQSAEITIPV
|
S180
|
|
HSP27 (cow)
|
LPKSATQSAEITIPV
|
S172
|
|
|
T180-p
|
AtQsNEItIPVtFEs
|
|
|
0
|
1
|
|
|
HSP27 (human)
|
AtQsNEItIPVtFEs
|
T180-p
|
|
HSP27 (mouse)
|
VTQsAEITIPVTFEA
|
T184
|
|
HSP27 (rat)
|
VTQSAEITIPVTFEA
|
T184
|
|
HSP27 (pig)
|
ATQSAEITIPVTFEA
|
T182
|
|
HSP27 (hamster)
|
ATQSAEITIPVTFEA
|
T188
|
|
HSP27 (chicken)
|
AIQSSEITIPVTVEA
|
T178
|
|
HSP27 (dog)
|
ATQSAEITIPVTFEA
|
T184
|
|
HSP27 (cow)
|
ATQSAEITIPVTFQA
|
T176
|
|
|
T184-p
|
NEItIPVtFEsRAQL
|
|
|
0
|
3
|
|
|
HSP27 (human)
|
NEItIPVtFEsRAQL
|
T184-p
|
|
HSP27 (mouse)
|
AEITIPVTFEARAQI
|
T188
|
|
HSP27 (rat)
|
AEITIPVTFEARAQI
|
T188
|
|
HSP27 (pig)
|
AEITIPVTFEARAQL
|
T186
|
|
HSP27 (hamster)
|
AEITIPVTFEARAQI
|
T192
|
|
HSP27 (chicken)
|
SEITIPVTVEAKKEE
|
T182
|
|
HSP27 (dog)
|
AEITIPVTFEARAQI
|
T188
|
|
HSP27 (cow)
|
AEITIPVTFQARAQL
|
T180
|
|
|
S187-p
|
tIPVtFEsRAQLGGP
|
|
|
0
|
3
|
|
|
HSP27 (human)
|
tIPVtFEsRAQLGGP
|
S187-p
|
|
HSP27 (mouse)
|
TIPVTFEARAQIGGP
|
A191
|
|
HSP27 (rat)
|
TIPVTFEARAQIGGP
|
A191
|
|
HSP27 (pig)
|
TIPVTFEARAQLGGT
|
A189
|
|
HSP27 (hamster)
|
TIPVTFEARAQIGGQ
|
A195
|
|
HSP27 (chicken)
|
gap
|
-
|
|
HSP27 (dog)
|
TIPVTFEARAQIGGP
|
A191
|
|
HSP27 (cow)
|
TIPVTFQARAQLGGP
|
A183
|
|
|
K198-ub
|
LGGPEAAksDEtAAk
|
|
|
0
|
53
|
|
|
HSP27 (human)
|
LGGPEAAksDEtAAk
|
K198-ub
|
|
HSP27 (mouse)
|
IGGPEAGksEQsGAK
|
K202-ub
|
|
HSP27 (rat)
|
gap
|
-
|
|
HSP27 (pig)
|
LGGTEAGKSEKPGTK
|
K200
|
|
HSP27 (hamster)
|
IGGQEAGKSEQSGAK
|
K206
|
|
HSP27 (chicken)
|
IPVTVEAKKEEPAKK
|
K186
|
|
HSP27 (dog)
|
IGGPEAGKSEQSGAK
|
K202
|
|
HSP27 (cow)
|
LGGPEAGKSEQPENK
|
K194
|
|
|
K198-sm
|
LGGPEAAksDEtAAk
|
|
|
0
|
2
|
|
|
HSP27 (human)
|
LGGPEAAksDEtAAk
|
K198-sm
|
|
HSP27 (mouse)
|
IGGPEAGKsEQsGAK
|
K202
|
|
HSP27 (rat)
|
gap
|
-
|
|
HSP27 (pig)
|
LGGTEAGKSEKPGTK
|
K200
|
|
HSP27 (hamster)
|
IGGQEAGKSEQSGAK
|
K206
|
|
HSP27 (chicken)
|
IPVTVEAKKEEPAKK
|
K186
|
|
HSP27 (dog)
|
IGGPEAGKSEQSGAK
|
K202
|
|
HSP27 (cow)
|
LGGPEAGKSEQPENK
|
K194
|
|
|
S199-p
|
GGPEAAksDEtAAk_
|
Upstream
|
|
0
|
23
|
|
|
|
|
HSP27 (human)
|
GGPEAAksDEtAAk_
|
S199-p
|
|
HSP27 (mouse)
|
GGPEAGksEQsGAK_
|
S203-p
|
|
HSP27 (rat)
|
AQIGGPESEQSGAK_
|
S200
|
|
HSP27 (pig)
|
GGTEAGKSEKPGTK_
|
S201
|
|
HSP27 (hamster)
|
GGQEAGKSEQSGAK_
|
S207
|
|
HSP27 (chicken)
|
PVTVEAKKEEPAKK_
|
K187
|
|
HSP27 (dog)
|
GGPEAGKSEQSGAK_
|
S203
|
|
HSP27 (cow)
|
GGPEAGKSEQPENK_
|
S195
|
|
|
T202-p
|
EAAksDEtAAk____
|
|
|
0
|
3
|
|
|
HSP27 (human)
|
EAAksDEtAAk____
|
T202-p
|
|
HSP27 (mouse)
|
EAGksEQsGAK____
|
S206-p
|
|
HSP27 (rat)
|
GGPESEQSGAK____
|
S203
|
|
HSP27 (pig)
|
EAGKSEKPGTK____
|
P204
|
|
HSP27 (hamster)
|
EAGKSEQSGAK____
|
S210
|
|
HSP27 (chicken)
|
VEAKKEEPAKK____
|
P190
|
|
HSP27 (dog)
|
EAGKSEQSGAK____
|
S206
|
|
HSP27 (cow)
|
EAGKSEQPENK____
|
P198
|
|
|
K205-ac
|
ksDEtAAk_______
|
|
|
0
|
53
|
|
|
HSP27 (human)
|
ksDEtAAk_______
|
K205-ac
|
|
HSP27 (mouse)
|
ksEQsGAK_______
|
K209
|
|
HSP27 (rat)
|
ESEQSGAK_______
|
K206
|
|
HSP27 (pig)
|
KSEKPGTK_______
|
K207
|
|
HSP27 (hamster)
|
KSEQSGAK_______
|
K213
|
|
HSP27 (chicken)
|
KKEEPAKK_______
|
K193
|
|
HSP27 (dog)
|
KSEQSGAK_______
|
K209
|
|
HSP27 (cow)
|
KSEQPENK_______
|
K201
|
|
|
K205-ub
|
ksDEtAAk_______
|
|
|
0
|
4
|
|
|
HSP27 (human)
|
ksDEtAAk_______
|
K205-ub
|
|
HSP27 (mouse)
|
ksEQsGAK_______
|
K209
|
|
HSP27 (rat)
|
ESEQSGAK_______
|
K206
|
|
HSP27 (pig)
|
KSEKPGTK_______
|
K207
|
|
HSP27 (hamster)
|
KSEQSGAK_______
|
K213
|
|
HSP27 (chicken)
|
KKEEPAKK_______
|
K193
|
|
HSP27 (dog)
|
KSEQSGAK_______
|
K209
|
|
HSP27 (cow)
|
KSEQPENK_______
|
K201
|
|
