Other Species / Isoforms
  TDP1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2-p
______MsQEGDYGR
0 1
TDP1 (human) ______MsQEGDYGR S2-p
TDP1 (mouse) ______MSQESSYGK S2
TDP1 (rat) ______MSQESSYGK S2
S15-p
GRWTISSsDEsEEEk
0 2
TDP1 (human) GRWTISSsDEsEEEk S15-p
TDP1 (mouse) GKWTISSSDESEDEK S15
TDP1 (rat) GKWTISSSDDSEDEK S15
S18-p
TISSsDEsEEEkPKP
0 4
TDP1 (human) TISSsDEsEEEkPKP S18-p
TDP1 (mouse) TISSSDESEDEKPKP S18
TDP1 (rat) TISSSDDSEDEKPKP S18
K22-sm
sDEsEEEkPKPDKPS
0 1
TDP1 (human) sDEsEEEkPKPDKPS K22-sm
TDP1 (mouse) SDESEDEKPKPDKPS K22
TDP1 (rat) SDDSEDEKPKPVKPS K22
Y46
GAANEPRYTCSEAQk
0 1
TDP1 (human) GAANEPRYTCSEAQk Y46
TDP1 (mouse) GVSKELIyTCSEARK Y46-p
TDP1 (rat) GVSKEPTYTCSEARK Y46
K53-ub
YTCSEAQkAAHKRKI
0 1
TDP1 (human) YTCSEAQkAAHKRKI K53-ub
TDP1 (mouse) yTCSEARKVAHKRQI K53
TDP1 (rat) YTCSEARKAAHKRQI K53
S61-p
AAHKRKIsPVKFSNT
Upstream
0 65
Treatment
  • LRRK2-IN-1
TDP1 (human) AAHKRKIsPVKFSNT S61-p
TDP1 (mouse) VAHKRQIsPVKFNDA S61-p
TDP1 (rat) AAHKRQIsPVKFNNT S61-p
S79-p
LPPKRQKsGsQEDLG
0 1
TDP1 (human) LPPKRQKsGsQEDLG S79-p
TDP1 (mouse) LPHKKQKSDSPEGLG S79
TDP1 (rat) LPHKKQKMDSPEGLG M79
S81-p
PKRQKsGsQEDLGWC
Upstream
Downstream
3 2
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
Kinase, in vitro:
  • ATM (human)
  • DNAPK (human)
Putative in vivo kinases:
  • ATM (human)
  • DNAPK (human)
Treatment
  • aphidicolin
  • camptothecin
  • DRB
  • hydroxyurea
  • ionizing_radiation
  • KU-55933
  • NU7441
TDP1 (human) PKRQKsGsQEDLGWC S81-p
TDP1 (mouse) HKKQKSDSPEGLGWC S81
TDP1 (rat) HKKQKMDSPEGLGWC S81
K112-sm
AEKVVIKkEkDISAP
0 1
TDP1 (human) AEKVVIKkEkDISAP K112-sm
TDP1 (mouse) under review -
TDP1 (rat) under review -
K114-ub
KVVIKkEkDISAPND
0 2
TDP1 (human) KVVIKkEkDISAPND K114-ub
TDP1 (mouse) KRVLPQEKKHVssPD K114
TDP1 (rat) KGVPPQEKKYAPSAN K114
S117
IKkEkDISAPNDGTA
0 3
TDP1 (human) IKkEkDISAPNDGTA S117
TDP1 (mouse) PQEKKHVssPDVTTA S118-p
TDP1 (rat) PQEKKYAPSANVTTA P118
A118
KkEkDISAPNDGTAQ
0 10
TDP1 (human) KkEkDISAPNDGTAQ A118
TDP1 (mouse) QEKKHVssPDVTTAQ S119-p
TDP1 (rat) QEKKYAPSANVTTAQ S119
G131
AQRTENHGAPACHRL
0 9
TDP1 (human) AQRTENHGAPACHRL G131
TDP1 (mouse) AQKVVDRsPPAsLRP S132-p
TDP1 (rat) AQKVEDRsPPDSHRA S132-p
C135
ENHGAPACHRLkEEE
0 1
TDP1 (human) ENHGAPACHRLkEEE C135
TDP1 (mouse) VDRsPPAsLRPQRAD S136-p
TDP1 (rat) EDRsPPDSHRAQRAD S136
K139-ub
APACHRLkEEEDEYE
0 2
TDP1 (human) APACHRLkEEEDEYE K139-ub
TDP1 (mouse) PPAsLRPQRADDEYE Q140
TDP1 (rat) PPDSHRAQRADEEYE Q140
K139-sm
APACHRLkEEEDEYE
0 3
TDP1 (human) APACHRLkEEEDEYE K139-sm
TDP1 (mouse) PPAsLRPQRADDEYE Q140
TDP1 (rat) PPDSHRAQRADEEYE Q140
T147-p
EEEDEYEtsGEGQDI
0 12
TDP1 (human) EEEDEYEtsGEGQDI T147-p
TDP1 (mouse) RADDEYEtsGEGQDI T148-p
TDP1 (rat) RADEEYEtsGEGQDI T148-p
S148-p
EEDEYEtsGEGQDIW
0 15
TDP1 (human) EEDEYEtsGEGQDIW S148-p
TDP1 (mouse) ADDEYEtsGEGQDIW S149-p
TDP1 (rat) ADEEYEtsGEGQDIW S149-p
K222-ub
YPPEFRKkPILLVHG
0 1
TDP1 (human) YPPEFRKkPILLVHG K222-ub
TDP1 (mouse) YPPEFRKNPILLVHG N223
TDP1 (rat) YPPEFRKKPILLVHG K223
K231
ILLVHGDKREAKAHL
0 1
TDP1 (human) ILLVHGDKREAKAHL K231
TDP1 (mouse) ILLVHGDKREAKADL K232
TDP1 (rat) ILLVHGDkREAKADL K232-ac
K231-ub
ILLVHGDkREAKAHL
0 1
TDP1 (human) ILLVHGDkREAKAHL K231-ub
TDP1 (mouse) ILLVHGDKREAKADL K232
TDP1 (rat) ILLVHGDKREAKADL K232
K243-ub
AHLHAQAkPYENISL
0 1
TDP1 (human) AHLHAQAkPYENISL K243-ub
TDP1 (mouse) ADLHAQAKPYANISL K244
TDP1 (rat) ADLHAQAKPYANISL K244
T309
YPRIADGTHkSGESP
0 3
TDP1 (human) YPRIADGTHkSGESP T309
TDP1 (mouse) YPRIDQGsHTAGESS S310-p
TDP1 (rat) YPRIYQGNHTSGESS N310
K311-ub
RIADGTHkSGESPTH
0 1
TDP1 (human) RIADGTHkSGESPTH K311-ub
TDP1 (mouse) under review -
TDP1 (rat) RIYQGNHTSGESSTH T312
S334-p
LMAYNAPsLKEWIDV
0 7
TDP1 (human) LMAYNAPsLKEWIDV S334-p
TDP1 (mouse) LTAYNAPPLQEWIDI P335
TDP1 (rat) LMAYNAPPLQEWIDI P335
S365-p
TPGRFQGsQkDNWGH
Upstream
1 1
Putative in vivo kinases:
  • ATM (human)
Treatment
  • hydroxyurea
  • ionizing_radiation
TDP1 (human) TPGRFQGsQkDNWGH S365-p
TDP1 (mouse) TPGRFQGSHRDNWGH S366
TDP1 (rat) TPGRFQGSHKDNWGH S366
K367-ub
GRFQGsQkDNWGHFR
0 1
TDP1 (human) GRFQGsQkDNWGHFR K367-ub
TDP1 (mouse) GRFQGSHRDNWGHFR R368
TDP1 (rat) GRFQGSHKDNWGHFR K368
K417-ub
KWLCSEFkESMLTLG
0 2
TDP1 (human) KWLCSEFkESMLTLG K417-ub
TDP1 (mouse) KWLCSEFKDSLLALR K418
TDP1 (rat) KWLCSEFKESLLAVR K418
K432-ub
KESKTPGkSsVPLYL
0 3
TDP1 (human) KESKTPGkSsVPLYL K432-ub
TDP1 (mouse) EEGRPPGKSAVPLHL K433
TDP1 (rat) EEGRTPGRSAVPLHL R433
S434-p
SKTPGkSsVPLYLIY
Upstream
0 2
Treatment
  • BI2536
TDP1 (human) SKTPGkSsVPLYLIY S434-p
TDP1 (mouse) GRPPGKSAVPLHLIY A435
TDP1 (rat) GRTPGRSAVPLHLIY A435
K469-ub
YSIQTAEkQNWLHSY
0 1
TDP1 (human) YSIQTAEkQNWLHSY K469-ub
TDP1 (mouse) YSIQTAEKQRWLHSY K470
TDP1 (rat) YGIQTAEKQRWLHPY K470
Y497
AMPHIKTYMRPSPDF
0 1
TDP1 (human) AMPHIKTYMRPSPDF Y497
TDP1 (mouse) AMPHIKTYMRPSPDF Y498
TDP1 (rat) AMPHIKTyMRPSPDF Y498-p
S518-p
LVTSANLsKAAWGAL
0 2
TDP1 (human) LVTSANLsKAAWGAL S518-p
TDP1 (mouse) LVTSANLSKAAWGAL S519
TDP1 (rat) LVTSANLSKAAWGAL S519
S563-p
KQKFFAGsQEPMATF
Upstream
1 9
Putative in vivo kinases:
  • ATM (human)
Treatment
  • hydroxyurea
  • ionizing_radiation
  • UV
TDP1 (human) KQKFFAGsQEPMATF S563-p
TDP1 (mouse) KQKFFSSSCEPTASF S564
TDP1 (rat) KQKFFSSSSEPMASF S564