Other Species / Isoforms
  FOXO3A (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S7-p
_MAEAPAsPAPLsPL
Upstream
Downstream
2 41
FOXO3A (human)
S7-p
FOXO3A (mouse)
S7-p
FOXO3A (rat)
S7-p
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • P38A (human)
Putative in vivo kinases:
  • P38A (human)
Treatment
  • adriamycin
  • anti-CD3
  • nocodazole
  • SB202190
FOXO3A (human) _MAEAPAsPAPLsPL S7-p
FOXO3A (mouse) _MAEAPAsPVPLsPL S7-p
FOXO3A (rat) _MAEAPAsPVPLsPL S7-p
S12-p
PAsPAPLsPLEVELD
Upstream
Downstream
1 36
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
  • P38A (human)
Treatment
  • anti-CD3
  • nocodazole
FOXO3A (human) PAsPAPLsPLEVELD S12-p
FOXO3A (mouse) PAsPVPLsPLEVELD S12-p
FOXO3A (rat) PAsPVPLsPLEVELD S12-p
S26-p
DPEFEPQsRPRsCtW
0 1
FOXO3A (human) DPEFEPQsRPRsCtW S26-p
FOXO3A (mouse) DPEFEPQSRPRSCtW S26
FOXO3A (rat) DPEFEPQSRPRSCtW S26
S30-p
EPQsRPRsCtWPLQR
Upstream
Downstream
1 6
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
FOXO3A (human) EPQsRPRsCtWPLQR S30-p
FOXO3A (mouse) EPQSRPRSCtWPLQR S30
FOXO3A (rat) EPQSRPRSCtWPLQR S30
T32-p
QsRPRsCtWPLQRPE
Upstream
Downstream
61 99
FOXO3A (human)
T32-p
FOXO3A (mouse)
T32-p
FOXO3A (rat)
T32-p
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, altered
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
  • Akt1 (rat)
  • Pim1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • Akt1 (human)
  • LKB1 (human)
  • Lmr3 (human)
  • NuaK1 (human)
  • PPP2CA (human)
  • RAGE (human)
  • SGK1 (human)
  • SIRT1 (human)
  • SIRT1 (mouse)
Treatment
  • 2-deoxyglucose
  • adriamycin
  • Akt-I-1
  • alpelisib
  • angiotensin_2
  • AZD8055
  • celecoxib
  • CML
  • Epo
  • gefitinib
  • GSK2334470
  • IGF-1
  • imatinib
  • insulin
  • KP-372-1
  • low_glucose
  • LY294002
  • methyl-beta-cyclodextrin
  • methylglyoxal
  • NAC
  • nicotinamide
  • okadaic_acid
  • PF-04691502
  • rapamycin
  • resveratrol
  • siRNA
  • SP600125
  • TGF-beta
  • TPO
  • virus infection
  • wortmannin
FOXO3A (human) QsRPRsCtWPLQRPE T32-p
FOXO3A (mouse) QSRPRSCtWPLQRPE T32-p
FOXO3A (rat) QSRPRSCtWPLQRPE T32-p
S43-p
QRPELQAsPAKPSGE
0 5
FOXO3A (human) QRPELQAsPAKPSGE S43-p
FOXO3A (mouse) QRPELQAsPAKPsGE S43-p
FOXO3A (rat) QRPELQASPAKPSGE S43
S48
QAsPAKPSGETAADS
0 1
FOXO3A (human) QAsPAKPSGETAADS S48
FOXO3A (mouse) QAsPAKPsGETAADs S48-p
FOXO3A (rat) QASPAKPSGETAADS S48
S55
SGETAADSMIPEEED
0 1
FOXO3A (human) SGETAADSMIPEEED S55
FOXO3A (mouse) sGETAADsMIPEEDD S55-p
FOXO3A (rat) SGETAADSMIPEEDD S55
S75-p
DGGGRAGsAMAIGGG
0 3
FOXO3A (human) DGGGRAGsAMAIGGG S75-p
FOXO3A (mouse) DGGGRASSAMVIGGG S75
FOXO3A (rat) DSGGRGSSAMVIGGG S75
S90-p
GGSGTLGsGLLLEDS
1 1
FOXO3A (human) GGSGTLGsGLLLEDS S90-p
FOXO3A (mouse) GVSSTLGsGLLLEDS S89-p
FOXO3A (rat) GVSSALGSGLLLEDS S89
S161-p
RNAWGNLsyADLITR
0 1
FOXO3A (human) RNAWGNLsyADLITR S161-p
FOXO3A (mouse) RNAWGNLSYADLITR S160
FOXO3A (rat) RNAWGNLSYADLITR S160
Y162-p
NAWGNLsyADLITRA
0 1
FOXO3A (human) NAWGNLsyADLITRA Y162-p
FOXO3A (mouse) NAWGNLSYADLITRA Y161
FOXO3A (rat) NAWGNLSYADLITRA Y161
T179-p
SSPDKRLtLSQIyEW
Upstream
Downstream
2 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • AMPKA2 (human)
Treatment
  • 2-deoxyglucose
  • growth_factor_withdrawal
FOXO3A (human) SSPDKRLtLSQIyEW T179-p
FOXO3A (mouse) SSPDKRLTLSQIYEW T178
FOXO3A (rat) SSPDKRLTLSQIYEW T178
Y184-p
RLtLSQIyEWMVRCV
0 9
FOXO3A (human) RLtLSQIyEWMVRCV Y184-p
FOXO3A (mouse) RLTLSQIYEWMVRCV Y183
FOXO3A (rat) RLTLSQIYEWMVRCV Y183
S209-p
SSAGWKNsIRHNLsL
Upstream
Downstream
4 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • MST1 (human)
Putative in vivo kinases:
  • MST1 (human)
Regulatory protein:
  • MST1 (human)
Treatment
  • Akt-I-1
  • H2O2
  • LY294002
  • SP600125
  • staurosporine
FOXO3A (human) SSAGWKNsIRHNLsL S209-p
FOXO3A (mouse) SSAGWKNsIRHNLSL S208-p
FOXO3A (rat) SSAGWKNSIRHNLSL S208
S215-p
NsIRHNLsLHSRFMR
Upstream
1 2
Kinase, in vitro:
  • MST1 (human)
FOXO3A (human) NsIRHNLsLHSRFMR S215-p
FOXO3A (mouse) NsIRHNLSLHSRFMR S214
FOXO3A (rat) NSIRHNLSLHSRFMR S214
S231-p
QNEGTGKssWWIINP
Upstream
1 0
Kinase, in vitro:
  • MST1 (human)
FOXO3A (human) QNEGTGKssWWIINP S231-p
FOXO3A (mouse) QNEGTGKSSWWIINP S230
FOXO3A (rat) QNEGTGKSSWWIINP S230
S232-p
NEGTGKssWWIINPD
Upstream
1 0
Kinase, in vitro:
  • MST1 (human)
FOXO3A (human) NEGTGKssWWIINPD S232-p
FOXO3A (mouse) NEGTGKSSWWIINPD S231
FOXO3A (rat) NEGTGKSSWWIINPD S231
K242-ac
IINPDGGksGkAPRR
Upstream
Downstream
5 0
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Treatment
  • LPS
  • nicotinamide
  • siRNA
  • trichostatin_A
FOXO3A (human) IINPDGGksGkAPRR K242-ac
FOXO3A (mouse) IINPDGGkSGKAPRR K241-ac
FOXO3A (rat) IINPDGGKSGKAPRR K241
S243-p
INPDGGksGkAPRRR
Upstream
1 0
Kinase, in vitro:
  • MST1 (human)
FOXO3A (human) INPDGGksGkAPRRR S243-p
FOXO3A (mouse) INPDGGkSGKAPRRR S242
FOXO3A (rat) INPDGGKSGKAPRRR S242
K245-ac
PDGGksGkAPRRRAV
1 0
FOXO3A (human) PDGGksGkAPRRRAV K245-ac
FOXO3A (mouse) PDGGkSGKAPRRRAV K244
FOXO3A (rat) PDGGKSGKAPRRRAV K244
S253-p
APRRRAVsMDNSNkY
Upstream
Downstream
24 92
FOXO3A (human)
S253-p
FOXO3A (mouse)
S252-p
FOXO3A (rat)
S252-p
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, inhibited
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell growth, induced
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • Akt1 (human)
  • Akt1 (mouse)
Phosphatases, in vitro:
  • PPP2CA (human)
Putative in vivo kinases:
  • Akt1 (human)
  • Akt1 (rat)
  • Pim1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Regulatory protein:
  • EWS (human)
  • IL2RA (human)
  • LKB1 (human)
  • PPP2CA (human)
  • SHC1 (human)
  • WISP2 (human)
Treatment
  • AG1024
  • Akt-I-1
  • anti-CD3/CD28
  • beta-amyloid_40
  • ebselen
  • Epo
  • glucose
  • IGF-1
  • imatinib
  • insulin
  • LY294002
  • nocodazole
  • okadaic_acid
  • phorbol_ester
  • rapamycin
  • resveratrol
  • siRNA
  • SP600125
  • tautomycetin
  • TGF-beta
FOXO3A (human) APRRRAVsMDNSNkY S253-p
FOXO3A (mouse) APRRRAVsMDNSNkY S252-p
FOXO3A (rat) APRRRAVsMDNSNkY S252-p
K259-ac
VsMDNSNkYTKSRGR
Upstream
Downstream
5 1
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Treatment
  • LPS
  • nicotinamide
  • siRNA
  • trichostatin_A
FOXO3A (human) VsMDNSNkYTKSRGR K259-ac
FOXO3A (mouse) VsMDNSNkYTKSRGR K258-ac
FOXO3A (rat) VsMDNSNkYTKSRGR K258-ac
K271-ac
RGRAAKKkAALQTAP
Upstream
Downstream
3 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
Treatment
  • cigarette_smoke
  • siRNA
FOXO3A (human) RGRAAKKkAALQTAP K271-ac
FOXO3A (mouse) RGRAAKKkAALQAAP K270-ac
FOXO3A (rat) RGRAAKKKAALQAAP K270
S280-p
ALQTAPEsADDsPsQ
0 16
FOXO3A (human) ALQTAPEsADDsPsQ S280-p
FOXO3A (mouse) ALQAAPEsADDsPsQ S279-p
FOXO3A (rat) ALQAAPESADDsPSQ S279
S284-p
APEsADDsPsQLskW
1 25
FOXO3A (human) APEsADDsPsQLskW S284-p
FOXO3A (mouse) APEsADDsPsQLSkW S283-p
FOXO3A (rat) APESADDsPSQLSKW S283-p
S286-p
EsADDsPsQLskWPG
0 3
FOXO3A (human) EsADDsPsQLskWPG S286-p
FOXO3A (mouse) EsADDsPsQLSkWPG S285-p
FOXO3A (rat) ESADDsPSQLSKWPG S285
S289-p
DDsPsQLskWPGsPt
0 2
FOXO3A (human) DDsPsQLskWPGsPt S289-p
FOXO3A (mouse) DDsPsQLSkWPGsPT S288
FOXO3A (rat) DDsPSQLSKWPGsPT S288
K290-ac
DsPsQLskWPGsPts
Upstream
Downstream
5 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Treatment
  • cigarette_smoke
  • LPS
  • nicotinamide
  • siRNA
  • trichostatin_A
FOXO3A (human) DsPsQLskWPGsPts K290-ac
FOXO3A (mouse) DsPsQLSkWPGsPTS K289-ac
FOXO3A (rat) DsPSQLSKWPGsPTS K289
S294-p
QLskWPGsPtsRsSD
Upstream
Downstream
4 81
FOXO3A (human)
S294-p
FOXO3A (mouse)
S293-p
FOXO3A (rat)
S293-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • ERK2 (human)
  • P38A (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
Treatment
  • ischemia
  • PD98059
FOXO3A (human) QLskWPGsPtsRsSD S294-p
FOXO3A (mouse) QLSkWPGsPTSRssD S293-p
FOXO3A (rat) QLSKWPGsPTSRSSD S293-p
T296-p
skWPGsPtsRsSDEL
0 2
FOXO3A (human) skWPGsPtsRsSDEL T296-p
FOXO3A (mouse) SkWPGsPTSRssDEL T295
FOXO3A (rat) SKWPGsPTSRSSDEL T295
S297-p
kWPGsPtsRsSDELD
0 2
FOXO3A (human) kWPGsPtsRsSDELD S297-p
FOXO3A (mouse) kWPGsPTSRssDELD S296
FOXO3A (rat) KWPGsPTSRSSDELD S296
S299-p
PGsPtsRsSDELDAW
Upstream
0 8
Treatment
  • ischemia
FOXO3A (human) PGsPtsRsSDELDAW S299-p
FOXO3A (mouse) PGsPTSRssDELDAW S298-p
FOXO3A (rat) PGsPTSRSSDELDAW S298
S300
GsPtsRsSDELDAWt
1 2
FOXO3A (human) GsPtsRsSDELDAWt S300
FOXO3A (mouse) GsPTSRssDELDAWT S299-p
FOXO3A (rat) GsPTSRSSDELDAWT S299
T307-p
SDELDAWtDFRsRTN
0 2
FOXO3A (human) SDELDAWtDFRsRTN T307-p
FOXO3A (mouse) sDELDAWTDFRsRTN T306
FOXO3A (rat) SDELDAWTDFRSRTN T306
S311-p
DAWtDFRsRTNsNAs
0 8
FOXO3A (human) DAWtDFRsRTNsNAs S311-p
FOXO3A (mouse) DAWTDFRsRTNsNAs S310-p
FOXO3A (rat) DAWTDFRSRTNSNAS S310
S315-p
DFRsRTNsNAstVsG
Upstream
Downstream
4 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
  • transcription, inhibited
Putative in vivo kinases:
  • SGK1 (human)
Treatment
  • IGF-1
  • LY294002
FOXO3A (human) DFRsRTNsNAstVsG S315-p
FOXO3A (mouse) DFRsRTNsNAsTVsG S314-p
FOXO3A (rat) DFRSRTNSNASTVSG S314
S318-p
sRTNsNAstVsGRLs
Upstream
Downstream
7 1
FOXO3A (human)
S318-p
FOXO3A (mouse)
S317-p
FOXO3A (rat)
S317-p
Effects on Biological Processes:
  • transcription, inhibited
Regulatory protein:
  • Lmr3 (human)
  • WISP2 (human)
Treatment
  • Akt-I-1
  • fasting
  • insulin
  • LY294002
  • Nodal
  • okadaic_acid
  • tautomycetin
FOXO3A (human) sRTNsNAstVsGRLs S318-p
FOXO3A (mouse) sRTNsNAsTVsGRLS S317-p
FOXO3A (rat) SRTNSNASTVSGRLS S317
T319-p
RTNsNAstVsGRLsP
0 1
FOXO3A (human) RTNsNAstVsGRLsP T319-p
FOXO3A (mouse) RTNsNAsTVsGRLSP T318
FOXO3A (rat) RTNSNASTVSGRLSP T318
S321-p
NsNAstVsGRLsPIM
Upstream
Downstream
7 0
FOXO3A (human)
S321-p
FOXO3A (mouse)
S320-p
FOXO3A (rat)
S320-p
Effects on Biological Processes:
  • transcription, inhibited
Regulatory protein:
  • Lmr3 (human)
Treatment
  • Akt-I-1
  • fasting
  • insulin
  • LY294002
  • Nodal
  • okadaic_acid
  • phorbol_ester
  • tautomycetin
FOXO3A (human) NsNAstVsGRLsPIM S321-p
FOXO3A (mouse) NsNAsTVsGRLSPIL S320-p
FOXO3A (rat) NSNASTVSGRLSPIL S320
S325-p
stVsGRLsPIMASTE
0 1
FOXO3A (human) stVsGRLsPIMASTE S325-p
FOXO3A (mouse) sTVsGRLSPILASTE S324
FOXO3A (rat) STVSGRLSPILASTE S324
S344-p
QDDDAPLsPMLYSSS
Upstream
Downstream
1 2
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • ERK2 (human)
  • P38A (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
Treatment
  • PD98059
FOXO3A (human) QDDDAPLsPMLYSSS S344-p
FOXO3A (mouse) QDDDGPLSPMLYSSS S343
FOXO3A (rat) QDDDGPLSPMLYSSS S343
S355-p
YSSSASLsPSVSKPC
0 1
FOXO3A (human) YSSSASLsPSVSKPC S355-p
FOXO3A (mouse) YSSSASLSPSVSKPC S354
FOXO3A (rat) YSSSASLSPSVSKPC S354
T395-p
DDLLDNItLPPsQPs
0 1
FOXO3A (human) DDLLDNItLPPsQPs T395-p
FOXO3A (mouse) DDLLDNIALPPSQPS A394
FOXO3A (rat) DDLLDNIALPPSQAS A394
S399-p
DNItLPPsQPsPTGG
Upstream
Downstream
2 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • AMPKA2 (human)
Treatment
  • 2-deoxyglucose
  • growth_factor_withdrawal
FOXO3A (human) DNItLPPsQPsPTGG S399-p
FOXO3A (mouse) DNIALPPSQPSPPGG S398
FOXO3A (rat) DNIALPPSQASPPGG S398
S402-p
tLPPsQPsPTGGLMQ
0 1
FOXO3A (human) tLPPsQPsPTGGLMQ S402-p
FOXO3A (mouse) ALPPSQPSPPGGLMQ S401
FOXO3A (rat) ALPPSQASPPGGLMQ S401
S413-p
GLMQRSSsFPYTTKG
Upstream
Downstream
5 9
FOXO3A (human)
S413-p
Effects on Modified Protein
  • activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • AMPKA2 (human)
Treatment
  • 2-deoxyglucose
  • Akt_inhibitor_VIII
  • compound_C
  • glucose_starvation
  • growth_factor_withdrawal
  • NU7026
  • phenformin
  • siRNA
FOXO3A (human) GLMQRSSsFPYTTKG S413-p
FOXO3A (mouse) GLMQRGSsFPYTAKs S412-p
FOXO3A (rat) GLMQRSSSFPYTAKS S412
G420
sFPYTTKGsGLGsPt
0 1
FOXO3A (human) sFPYTTKGsGLGsPt G420
FOXO3A (mouse) sFPYTAKssGLGsPt S419-p
FOXO3A (rat) SFPYTAKSSGLGSPT S419
S421-p
FPYTTKGsGLGsPtS
0 4
FOXO3A (human) FPYTTKGsGLGsPtS S421-p
FOXO3A (mouse) FPYTAKssGLGsPtG S420-p
FOXO3A (rat) FPYTAKSSGLGSPTS S420
S425-p
TKGsGLGsPtSSFNS
Upstream
Downstream
3 10
FOXO3A (human)
S425-p
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • ERK2 (human)
  • P38A (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
Treatment
  • ischemia
  • PD98059
FOXO3A (human) TKGsGLGsPtSSFNS S425-p
FOXO3A (mouse) AKssGLGsPtGsFNs S424-p
FOXO3A (rat) AKSSGLGSPTSSFNS S424
T427-p
GsGLGsPtSSFNSTV
1 4
FOXO3A (human) GsGLGsPtSSFNSTV T427-p
FOXO3A (mouse) ssGLGsPtGsFNstV T426-p
FOXO3A (rat) SSGLGSPTSSFNSTV T426
S429
GLGsPtSSFNSTVFG
0 1
FOXO3A (human) GLGsPtSSFNSTVFG S429
FOXO3A (mouse) GLGsPtGsFNstVFG S428-p
FOXO3A (rat) GLGSPTSSFNSTVFG S428
S432
sPtSSFNSTVFGPSs
0 1
FOXO3A (human) sPtSSFNSTVFGPSs S432
FOXO3A (mouse) sPtGsFNstVFGPSS S431-p
FOXO3A (rat) SPTSSFNSTVFGPAS S431
T433
PtSSFNSTVFGPSsL
0 1
FOXO3A (human) PtSSFNSTVFGPSsL T433
FOXO3A (mouse) PtGsFNstVFGPSSL T432-p
FOXO3A (rat) PTSSFNSTVFGPASL T432
S439-p
STVFGPSsLNSLRQS
0 1
FOXO3A (human) STVFGPSsLNSLRQS S439-p
FOXO3A (mouse) stVFGPSSLNSLRQS S438
FOXO3A (rat) STVFGPASLNSLRQS S438
S551-p
LGGSRALsNsVsNMG
0 2
FOXO3A (human) LGGSRALsNsVsNMG S551-p
FOXO3A (mouse) LGGSRALSNSVSNMG S550
FOXO3A (rat) LGGSRALSNSVSNMG S550
S553-p
GSRALsNsVsNMGLS
0 1
FOXO3A (human) GSRALsNsVsNMGLS S553-p
FOXO3A (mouse) GSRALSNSVSNMGLS S552
FOXO3A (rat) GSRALSNSVSNMGLS S552
S555-p
RALsNsVsNMGLSES
Upstream
Downstream
2 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • AMPKA2 (human)
Treatment
  • 2-deoxyglucose
  • growth_factor_withdrawal
FOXO3A (human) RALsNsVsNMGLSES S555-p
FOXO3A (mouse) RALSNSVSNMGLSDS S554
FOXO3A (rat) RALSNSVSNMGLSDS S554
K569-ac
SSSLGSAkHQQQsPV
Upstream
Downstream
3 0
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Treatment
  • LPS
  • nicotinamide
  • siRNA
  • trichostatin_A
FOXO3A (human) SSSLGSAkHQQQsPV K569-ac
FOXO3A (mouse) SSSLGSAkHQQQsPA K568-ac
FOXO3A (rat) SSSLGSAKHQQQSPV K568
S574-p
SAkHQQQsPVSQSMQ
Upstream
Downstream
4 2
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
  • transcription, inhibited
Putative in vivo kinases:
  • JNK1 (human)
Regulatory protein:
  • SIRT1 (human)
  • SIRT7 (human)
Treatment
  • ethanol
  • LPS
  • SP600125
  • TRAIL
FOXO3A (human) SAkHQQQsPVSQSMQ S574-p
FOXO3A (mouse) SAkHQQQsPASQSMQ S573-p
FOXO3A (rat) SAKHQQQSPVSQSMQ S573
S588-p
QTLSDSLsGSSLYST
Upstream
Downstream
2 1
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • AMPKA2 (human)
Treatment
  • 2-deoxyglucose
  • compound_C
  • growth_factor_withdrawal
FOXO3A (human) QTLSDSLsGSSLYST S588-p
FOXO3A (mouse) QTLSDSLSGSSLYSA S587
FOXO3A (rat) QTLSDSLSGSSLYSA S587
S626-p
SLECDMEsIIRSELM
Upstream
Downstream
3 1
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • AMPKA2 (human)
Treatment
  • 2-deoxyglucose
  • growth_factor_withdrawal
FOXO3A (human) SLECDMEsIIRSELM S626-p
FOXO3A (mouse) SLECDMESIIRSELM S625
FOXO3A (rat) SLECDMESIIRSELM S625
S644-p
GLDFNFDsLISTQNV
Upstream
Downstream
2 0
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • protein degradation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell cycle regulation
  • transcription, inhibited
Kinase, in vitro:
  • IKKA (human)
  • IKKB (human)
  • IKKE (human)
Putative in vivo kinases:
  • IKKB (human)
  • IKKE (human)
Treatment
  • TNF
FOXO3A (human) GLDFNFDsLISTQNV S644-p
FOXO3A (mouse) GLDFNFDSLISTQNV S643
FOXO3A (rat) GLDFNFDSLISTQNV S643