Other Species / Isoforms
  FOXO1A (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T24-p
LPRPRSCtWPLPRPE
Upstream
Downstream
51 45
FOXO1A (human)
T24-p
FOXO1A (mouse)
T24-p
FOXO1A (rat)
T24-p
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • Akt1 (human)
  • Akt2 (human)
  • Akt3 (human)
  • IRS1 (human)
  • PDK1 (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PINK1 (human)
Treatment
  • AG1478
  • Akt-I-1
  • anti-CD3
  • AZD8055
  • BAR501
  • BDNF
  • EGF
  • Epo
  • H2O2
  • HGF
  • IGF-1
  • IL-2
  • imatinib
  • insulin
  • K252a
  • LY294002
  • neurotrophin-3
  • neurotrophin-4
  • NGF
  • PD98059
  • rapamycin
  • resveratrol
  • SCF
  • siRNA
  • wortmannin
FOXO1A (human) LPRPRSCtWPLPRPE T24-p
FOXO1A (mouse) LPRQRSCtWPLPRPE T24-p
FOXO1A (rat) LPRQRSCtWPLPRPE T24-p
S153-p
AGQPRKSsSSRRNAW
Upstream
1 0
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
Treatment
  • cAMP_analog
  • glucagon
  • siRNA
FOXO1A (human) AGQPRKSsSSRRNAW S153-p
FOXO1A (mouse) AGQPRKTsSSRRNAW S150-p
FOXO1A (rat) AGQPRKTSSSRRNAW S147
T182-p
SSAEKRLtLSQIYEW
1 0
FOXO1A (human) SSAEKRLtLSQIYEW T182-p
FOXO1A (mouse) SSAEKRLTLSQIYEW T179
FOXO1A (rat) SSAEKRLTLSQIYEW T176
S212-p
SSAGWKNsIRHNLsL
Downstream
3 0
Effects on Modified Protein
  • molecular association, regulation
FOXO1A (human) SSAGWKNsIRHNLsL S212-p
FOXO1A (mouse) SSAGWKNsIRHNLSL S209-p
FOXO1A (rat) SSAGWKNsIRHNLSL S206-p
S218-p
NsIRHNLsLHSkFIR
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
FOXO1A (human) NsIRHNLsLHSkFIR S218-p
FOXO1A (mouse) NsIRHNLSLHSKFIR S215
FOXO1A (rat) NsIRHNLSLHSKFIR S212
K222-ac
HNLsLHSkFIRVQNE
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • phosphorylation
FOXO1A (human) HNLsLHSkFIRVQNE K222-ac
FOXO1A (mouse) HNLSLHSKFIRVQNE K219
FOXO1A (rat) HNLSLHSKFIRVQNE K216
S234-p
QNEGTGKssWWMLNP
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
FOXO1A (human) QNEGTGKssWWMLNP S234-p
FOXO1A (mouse) QNEGTGKSSWWMLNP S231
FOXO1A (rat) QNEGTGKSSWWMLNP S228
S235-p
NEGTGKssWWMLNPE
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
FOXO1A (human) NEGTGKssWWMLNPE S235-p
FOXO1A (mouse) NEGTGKSSWWMLNPE S232
FOXO1A (rat) NEGTGKSSWWMLNPE S229
K245-ac
MLNPEGGkSGksPrR
Downstream
7 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
FOXO1A (human) MLNPEGGkSGksPrR K245-ac
FOXO1A (mouse) MLNPEGGKSGKsPRR K242
FOXO1A (rat) MLNPEGGKSGKsPRR K239
K248-ac
PEGGkSGksPrRrAA
Downstream
7 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
FOXO1A (human) PEGGkSGksPrRrAA K248-ac
FOXO1A (mouse) PEGGKSGKsPRRRAA K245
FOXO1A (rat) PEGGKSGKsPRRRAA K242
S249-p
EGGkSGksPrRrAAs
Upstream
Downstream
12 3
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • cell cycle regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (mouse)
  • CDK4 (human)
Putative in vivo kinases:
  • CDK1 (human)
  • CDK1 (mouse)
  • CDK2 (human)
  • CDK4 (human)
  • CDK5 (human)
Regulatory protein:
  • Chk2 (human)
  • OSBPL8 (mouse)
Treatment
  • camptothecin
  • insulin
  • ionizing_radiation
  • nocodazole
  • UCN-01
FOXO1A (human) EGGkSGksPrRrAAs S249-p
FOXO1A (mouse) EGGKSGKsPRRRAAs S246-p
FOXO1A (rat) EGGKSGKsPRRRAAs S243-p
R251-me
GkSGksPrRrAAsMD
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
FOXO1A (human) GkSGksPrRrAAsMD R251-me
FOXO1A (mouse) GKSGKsPRRRAAsMD R248
FOXO1A (rat) GKSGKsPRRRAAsMD R245
R253-me
SGksPrRrAAsMDNN
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
FOXO1A (human) SGksPrRrAAsMDNN R253-me
FOXO1A (mouse) SGKsPRRRAAsMDNN R250
FOXO1A (rat) SGKsPRRRAAsMDNN R247
S256-p
sPrRrAAsMDNNSkF
Upstream
Downstream
79 54
FOXO1A (human)
S256-p
FOXO1A (mouse)
S253-p
FOXO1A (rat)
S250-p
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • Akt1 (human)
  • IL2RA (human)
  • Notch 1 (human)
  • p53 (human)
  • PDK1 (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PTPRJ (human)
  • SHC1 (human)
  • SHIP (human)
  • Snail1 (human)
Treatment
  • 2-deoxyglucose
  • AG1478
  • Akt-I-1
  • Akt-I-1,2
  • angiotensin-(1-7)
  • anti-CD3
  • anti-CD3/CD28
  • AZD8055
  • BDNF
  • beta-amyloid_40
  • BMS-345541
  • C5b-9
  • CTGF
  • cycloheximide
  • ebselen
  • EGF
  • estrogen_deprivation
  • glucagon
  • GSK690693
  • H2O2
  • HGF
  • IGF-1
  • imatinib
  • insulin
  • interleukin-6-hydroxymethyl-chiro-inositol-2(R)-2-methyl-3-O-octadecylcarbonate
  • IQA
  • K252a
  • LY294002
  • neurotrophin-3
  • neurotrophin-4
  • NGF
  • oxidative_stress
  • PD184352
  • PD98059
  • PP2
  • QLT0254
  • rapamycin
  • resveratrol
  • sardomozide
  • SH-5
  • siRNA
  • TBB
  • wortmannin
FOXO1A (human) sPrRrAAsMDNNSkF S256-p
FOXO1A (mouse) sPRRRAAsMDNNSKF S253-p
FOXO1A (rat) sPRRRAAsMDNNSkF S250-p
K262-ac
AsMDNNSkFAkSRSR
Downstream
5 1
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
FOXO1A (human) AsMDNNSkFAkSRSR K262-ac
FOXO1A (mouse) AsMDNNSKFAKSRGR K259
FOXO1A (rat) AsMDNNSkFAKSRGR K256-ac
K265-ac
DNNSkFAkSRSRAAK
Downstream
7 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
FOXO1A (human) DNNSkFAkSRSRAAK K265-ac
FOXO1A (mouse) DNNSKFAKSRGRAAK K262
FOXO1A (rat) DNNSkFAKSRGRAAK K259
K274-ac
RSRAAKKkAsLQSGQ
Downstream
3 0
Effects on Modified Protein
  • intracellular localization
  • phosphorylation
FOXO1A (human) RSRAAKKkAsLQSGQ K274-ac
FOXO1A (mouse) RGRAAKKKAsLQSGQ K271
FOXO1A (rat) RGRAAKKKASLQSGQ K268
S276-p
RAAKKkAsLQSGQEG
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
  • protein stabilization
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
Treatment
  • cAMP_analog
  • glucagon
  • siRNA
FOXO1A (human) RAAKKkAsLQSGQEG S276-p
FOXO1A (mouse) RAAKKKAsLQSGQEG S273-p
FOXO1A (rat) RAAKKKASLQSGQEG S270
S287-p
GQEGAGDsPGSQFsk
Upstream
Downstream
4 24
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Treatment
  • nocodazole
FOXO1A (human) GQEGAGDsPGSQFsk S287-p
FOXO1A (mouse) GQEGPGDsPGSQFSK S284-p
FOXO1A (rat) GQEGPGDsPGSQFSK S281-p
S293-p
DsPGSQFskWPAsPG
0 1
FOXO1A (human) DsPGSQFskWPAsPG S293-p
FOXO1A (mouse) DsPGSQFSKWPAsPG S290
FOXO1A (rat) DsPGSQFSKWPASPG S287
K294-ac
sPGSQFskWPAsPGs
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • phosphorylation
FOXO1A (human) sPGSQFskWPAsPGs K294-ac
FOXO1A (mouse) sPGSQFSKWPAsPGS K291
FOXO1A (rat) sPGSQFSKWPASPGS K288
S298-p
QFskWPAsPGsHsND
Upstream
Downstream
6 40
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • CDK2 (mouse)
FOXO1A (human) QFskWPAsPGsHsND S298-p
FOXO1A (mouse) QFSKWPAsPGSHsND S295-p
FOXO1A (rat) QFSKWPASPGSHSND S292
S301-p
kWPAsPGsHsNDDFD
0 8
FOXO1A (human) kWPAsPGsHsNDDFD S301-p
FOXO1A (mouse) KWPAsPGSHsNDDFD S298
FOXO1A (rat) KWPASPGSHSNDDFD S295
S303-p
PAsPGsHsNDDFDNW
0 8
FOXO1A (human) PAsPGsHsNDDFDNW S303-p
FOXO1A (mouse) PAsPGSHsNDDFDNW S300-p
FOXO1A (rat) PASPGSHSNDDFDNW S297
T317-gl
WSTFRPRtssNAstI
1 0
FOXO1A (human) WSTFRPRtssNAstI T317-gl
FOXO1A (mouse) WSTFRPRTSsNAstI T314
FOXO1A (rat) WSTFRPRTSsNAsTI T311
S318-gl
STFRPRtssNAstIs
1 0
FOXO1A (human) STFRPRtssNAstIs S318-gl
FOXO1A (mouse) STFRPRTSsNAstIS S315
FOXO1A (rat) STFRPRTSsNAsTIs S312
S319-p
TFRPRtssNAstIsG
Upstream
Downstream
25 30
FOXO1A (human)
S319-p
FOXO1A (mouse)
S316-p
FOXO1A (rat)
S313-p
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • Akt1 (human)
  • JNK1 (human)
  • LKB1 (human)
  • PDK1 (human)
Treatment
  • BDNF
  • hepatitis C virus expression
  • IGF-1
  • insulin
  • NAC
  • neurotrophin-3
  • neurotrophin-4
  • NGF
  • PD98059
  • rapamycin
  • siRNA
  • SP600125
  • wortmannin
FOXO1A (human) TFRPRtssNAstIsG S319-p
FOXO1A (mouse) TFRPRTSsNAstISG S316-p
FOXO1A (rat) TFRPRTSsNAsTIsG S313-p
S322-p
PRtssNAstIsGRLs
Upstream
Downstream
6 0
Effects on Modified Protein
  • intracellular localization
Kinase, in vitro:
  • CK1A (human)
Treatment
  • Akt-I-1
  • IGF-1
  • LY294002
  • wortmannin
FOXO1A (human) PRtssNAstIsGRLs S322-p
FOXO1A (mouse) PRTSsNAstISGRLs S319-p
FOXO1A (rat) PRTSsNAsTIsGRLs S316-p
T323-p
RtssNAstIsGRLsP
0 2
FOXO1A (human) RtssNAstIsGRLsP T323-p
FOXO1A (mouse) RTSsNAstISGRLsP T320-p
FOXO1A (rat) RTSsNAsTIsGRLsP T317
S325-p
ssNAstIsGRLsPIM
Upstream
Downstream
5 0
Effects on Modified Protein
  • intracellular localization
Kinase, in vitro:
  • CK1A (human)
Treatment
  • Akt-I-1
  • IGF-1
  • LY294002
  • wortmannin
FOXO1A (human) ssNAstIsGRLsPIM S325-p
FOXO1A (mouse) SsNAstISGRLsPIM S322
FOXO1A (rat) SsNAsTIsGRLsPIM S319-p
S329-p
stIsGRLsPIMtEQD
Upstream
Downstream
11 30
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
  • transcription, inhibited
Kinase, in vitro:
  • DYRK1A (rabbit)
Putative in vivo kinases:
  • DYRK1A (human)
  • NLK (human)
Regulatory protein:
  • PDK1 (human)
Treatment
  • amino_acid_starvation
  • BMS-345541
  • carbachol
  • EGF
  • glucose_starvation
  • GSK690693
  • IGF-1
  • imatinib
  • ionomycin
  • phorbol_ester
  • siRNA
  • UV
FOXO1A (human) stIsGRLsPIMtEQD S329-p
FOXO1A (mouse) stISGRLsPIMtEQD S326-p
FOXO1A (rat) sTIsGRLsPIMTEQD S323-p
T333-p
GRLsPIMtEQDDLGE
0 2
FOXO1A (human) GRLsPIMtEQDDLGE T333-p
FOXO1A (mouse) GRLsPIMtEQDDLGD T330-p
FOXO1A (rat) GRLsPIMTEQDDLGD T327
S383-p
DNLNLLSsPTSLTVS
Downstream
2 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
FOXO1A (human) DNLNLLSsPTSLTVS S383-p
FOXO1A (mouse) DNLNLLSsPTSLTVS S380-p
FOXO1A (rat) DNLNLLSSPTSLTVS S377
S394-p
LTVSTQSsPGTMMQQ
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
FOXO1A (human) LTVSTQSsPGTMMQQ S394-p
FOXO1A (mouse) LTVSTQSsPGSMMQQ S391-p
FOXO1A (rat) LTVSTQSSPGSMMQQ S388
T402-p
PGTMMQQtPCYSFAP
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
FOXO1A (human) PGTMMQQtPCYSFAP T402-p
FOXO1A (mouse) PGSMMQQtPCYSFAP T399-p
FOXO1A (rat) PGSMMQQTPCYSFAP T396
S416-p
PPNTSLNsPsPNYQK
Downstream
4 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
FOXO1A (human) PPNTSLNsPsPNYQK S416-p
FOXO1A (mouse) PPNTSLNsPsPNYSK S413-p
FOXO1A (rat) PPNTSLNSPSPNYAK S410
S418-p
NTSLNsPsPNYQKYT
Downstream
4 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
FOXO1A (human) NTSLNsPsPNYQKYT S418-p
FOXO1A (mouse) NTSLNsPsPNYSKYT S415-p
FOXO1A (rat) NTSLNSPSPNYAKYT S412
S432-p
TYGQSSMsPLPQMPI
2 3
FOXO1A (human) TYGQSSMsPLPQMPI S432-p
FOXO1A (mouse) TYGQSSMsPLPQMPM S429-p
FOXO1A (rat) TYGQSSMSPVPQMPM S426
T467-p
GLLKELLtSDsPPHN
0 3
FOXO1A (human) GLLKELLtSDsPPHN T467-p
FOXO1A (mouse) GLLKELLtsDsPPHN T464-p
FOXO1A (rat) GLLKELLTSDSPPHN T461
S468
LLKELLtSDsPPHND
0 1
FOXO1A (human) LLKELLtSDsPPHND S468
FOXO1A (mouse) LLKELLtsDsPPHND S465-p
FOXO1A (rat) LLKELLTSDSPPHND S462
S470-p
KELLtSDsPPHNDIM
3 9
FOXO1A (human) KELLtSDsPPHNDIM S470-p
FOXO1A (mouse) KELLtsDsPPHNDIM S467-p
FOXO1A (rat) KELLTSDSPPHNDIM S464
T478
PPHNDIMTPVDPGVA
3 1
FOXO1A (human) PPHNDIMTPVDPGVA T478
FOXO1A (mouse) PPHNDIMsPVDPGVA S475-p
FOXO1A (rat) PPHNDIMSPVDPGVA S472
S502
NVMMGPNSVMsTYGs
1 0
FOXO1A (human) NVMMGPNSVMsTYGs S502
FOXO1A (mouse) NVMMGPNsVMPAYGS S499-p
FOXO1A (rat) NVLMGPNSVMPAYGS S496
S505-p
MGPNSVMsTYGsQAS
0 1
FOXO1A (human) MGPNSVMsTYGsQAS S505-p
FOXO1A (mouse) MGPNsVMPAYGSQAS P502
FOXO1A (rat) MGPNSVMPAYGSQAP P499
S509-p
SVMsTYGsQASHNKM
0 1
FOXO1A (human) SVMsTYGsQASHNKM S509-p
FOXO1A (mouse) sVMPAYGSQASHNKM S506
FOXO1A (rat) SVMPAYGSQAPHNKM S503
S550-gl
VSTMPHTsGMNRLTQ
1 0
FOXO1A (human) VSTMPHTsGMNRLTQ S550-gl
FOXO1A (mouse) VNTMPHTSAMNRLtP S547
FOXO1A (rat) VNTMPHTSAMNRLTP S544
T556
TsGMNRLTQVKTPVQ
1 1
FOXO1A (human) TsGMNRLTQVKTPVQ T556
FOXO1A (mouse) TSAMNRLtPVKtPLQ T553-p
FOXO1A (rat) TSAMNRLTPVKTPLQ T550
T560
NRLTQVKTPVQVPLP
1 0
FOXO1A (human) NRLTQVKTPVQVPLP T560
FOXO1A (mouse) NRLtPVKtPLQVPLS T557-p
FOXO1A (rat) NRLTPVKTPLQVPLS T554
K597-ac
MGLLHQEkLPSDLDG
0 1
FOXO1A (human) MGLLHQEkLPSDLDG K597-ac
FOXO1A (mouse) MGVLHQEKLPSDLDG K594
FOXO1A (rat) MGVLHQEKLPSDLDG K591
T648-gl
FPHSVKTttHsWVsG
1 0
FOXO1A (human) FPHSVKTttHsWVsG T648-gl
FOXO1A (mouse) FPHSVKTTTHSWVSG T645
FOXO1A (rat) FPHSVKTTTHSWVSG T642
T649-p
PHSVKTttHsWVsG_
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
FOXO1A (human) PHSVKTttHsWVsG_ T649-p
FOXO1A (mouse) PHSVKTTTHSWVSG_ T646
FOXO1A (rat) PHSVKTTTHSWVSG_ T643
S651-p
SVKTttHsWVsG___
0 1
FOXO1A (human) SVKTttHsWVsG___ S651-p
FOXO1A (mouse) SVKTTTHSWVSG___ S648
FOXO1A (rat) SVKTTTHSWVSG___ S645
S654-gl
TttHsWVsG______
1 0
FOXO1A (human) TttHsWVsG______ S654-gl
FOXO1A (mouse) TTTHSWVSG______ S651
FOXO1A (rat) TTTHSWVSG______ S648