Other Species / Isoforms
  ER-alpha (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T7-p
_MTMTLHtKAsGMAL
0 1
ER-alpha (human) _MTMTLHtKAsGMAL T7-p
ER-alpha (mouse) _MTMTLHTKAsGMAL T7
ER-alpha (rat) _MTMTLHTKASGMAL T7
S10-p
MTLHtKAsGMALLHQ
0 1
ER-alpha (human) MTLHtKAsGMALLHQ S10-p
ER-alpha (mouse) MTLHTKASGMALLHQ S10
ER-alpha (rat) MTLHTKASGMALLHQ S10
S10
MTLHtKASGMALLHQ
1 0
ER-alpha (human) MTLHtKASGMALLHQ S10
ER-alpha (mouse) MTLHTKAsGMALLHQ S10-gl
ER-alpha (rat) MTLHTKASGMALLHQ S10
K32-ac
PLNRPQLkIPLERPL
1 0
ER-alpha (human) PLNRPQLkIPLERPL K32-ac
ER-alpha (mouse) PLNRPQLKMPMERAL K32
ER-alpha (rat) PLNRPQLKMPMERAL K32
S46-p
LGEVYLDssKPAVyN
Downstream
1 0
Effects on Modified Protein
  • activity, induced
Effects on Biological Processes:
  • transcription, altered
ER-alpha (human) LGEVYLDssKPAVyN S46-p
ER-alpha (mouse) LGEVYVDNSKPtVFN N46
ER-alpha (rat) LGEVYVDNSKPAVFN N46
S47-p
GEVYLDssKPAVyNY
Downstream
1 0
Effects on Modified Protein
  • activity, induced
Effects on Biological Processes:
  • transcription, altered
ER-alpha (human) GEVYLDssKPAVyNY S47-p
ER-alpha (mouse) GEVYVDNSKPtVFNY S47
ER-alpha (rat) GEVYVDNSKPAVFNY S47
A50
YLDssKPAVyNYPEG
1 0
ER-alpha (human) YLDssKPAVyNYPEG A50
ER-alpha (mouse) YVDNSKPtVFNYPEG T50-gl
ER-alpha (rat) YVDNSKPAVFNYPEG A50
Y52-p
DssKPAVyNYPEGAA
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • transcription, induced
Kinase, in vitro:
  • Abl (human)
Putative in vivo kinases:
  • Abl (human)
Treatment
  • imatinib
ER-alpha (human) DssKPAVyNYPEGAA Y52-p
ER-alpha (mouse) DNSKPtVFNYPEGAA F52
ER-alpha (rat) DNSKPAVFNYPEGAA F52
S102-p
GGFPPLNsVsPsPLM
Upstream
Downstream
3 1
Effects on Modified Protein
  • activity, induced
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • estradiol
  • lithium
ER-alpha (human) GGFPPLNsVsPsPLM S102-p
ER-alpha (mouse) GAFPQLNSVSPSPLM S106
ER-alpha (rat) GAFPQLNSVSPSPLM S107
S104-p
FPPLNsVsPsPLMLL
Upstream
Downstream
22 1
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • CDK2 (human)
  • CDK3 (human)
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
Putative in vivo kinases:
  • CDK3 (human)
  • ERK1 (human)
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
Regulatory protein:
  • HER2 (human)
  • HRas (human)
  • IGF1R (human)
  • MEMO1 (human)
  • MLL3 (human)
  • RAF1 (human)
  • Raptor (mouse)
Treatment
  • 17-beta-estradiol
  • 4-HT
  • cholera_toxin
  • EGF
  • estradiol
  • faslodex
  • GDNF
  • IBMX
  • ICI164,384
  • lithium
  • LY294002
  • PD98059
  • phorbol_ester
  • siRNA
  • TOT
  • U0126
ER-alpha (human) FPPLNsVsPsPLMLL S104-p
ER-alpha (mouse) FPQLNSVSPSPLMLL S108
ER-alpha (rat) FPQLNSVSPSPLMLL S109
S106-p
PLNsVsPsPLMLLHP
Upstream
Downstream
23 1
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • CDK2 (human)
  • CDK3 (human)
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
Putative in vivo kinases:
  • CDK3 (human)
  • ERK1 (human)
  • ERK2 (human)
  • GSK3B (human)
  • mTOR (human)
Regulatory protein:
  • AREG (human)
  • HER2 (human)
  • HRas (human)
  • IGF1R (human)
  • MEMO1 (human)
  • MLL3 (human)
  • RAF1 (human)
  • Raptor (mouse)
Treatment
  • 17-beta-estradiol
  • 4-HT
  • bisphenol_A
  • cholera_toxin
  • EGF
  • estradiol
  • faslodex
  • GDNF
  • IBMX
  • ICI164,384
  • lithium
  • LY294002
  • PD98059
  • phorbol_ester
  • siRNA
  • TOT
  • U0126
ER-alpha (human) PLNsVsPsPLMLLHP S106-p
ER-alpha (mouse) QLNSVSPSPLMLLHP S110
ER-alpha (rat) QLNSVSPSPLMLLHP S111
S118-p
LHPPPQLsPFLQPHG
Upstream
Downstream
81 2
ER-alpha (human)
S118-p
ER-alpha (mouse)
S122-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, altered
  • carcinogenesis, induced
  • cell growth, altered
  • cell growth, induced
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • CDK2 (human)
  • CDK3 (human)
  • CDK7 (human)
  • ERK1 (human)
  • ERK2 (human)
  • GSK3B (human)
  • IKKA (human)
Phosphatases, in vitro:
  • PPP2CB (human)
Putative in vivo kinases:
  • CDK3 (human)
  • CDK7 (human)
  • ERK1 (human)
  • ERK2 (human)
  • GSK3B (human)
  • P38A (human)
Putative upstream phosphatases:
  • PPP2CA (human)
  • PPP2CB (human)
  • PPP5C (human)
Regulatory protein:
  • Akt1 (human)
  • DUSP22 (human)
  • DUSP6 (human)
  • EGFR (human)
  • ER-alpha (human)
  • FAS (human)
  • FKBPL (human)
  • HER2 (human)
  • HRas (human)
  • IGF1R (human)
  • ILK (human)
  • Lmr3 (human)
  • MEK1 (human)
  • MEMO1 (human)
  • MKK6 (human)
  • MLL3 (human)
  • NR2F1 (human)
  • P38A (human)
  • PAK1 (human)
  • RAF1 (human)
  • Ret (human)
  • TGFBR2 (human)
  • XPG (human)
Treatment
  • 17-beta-estradiol
  • 3-aminobenzamide
  • 4-HT
  • AG490
  • Akt_inhibitor_VIII
  • AMP-PNP
  • ATP
  • Bay_11-7082
  • black_tea_polyphenols
  • catalase
  • cholera_toxin
  • colforsin
  • DRB
  • EGF
  • estradiol
  • ethanol
  • faslodex
  • GDNF
  • geldanamycin
  • genistein
  • glucose_oxidase
  • IBMX
  • ICI164,384
  • ICI_164384
  • IGF-1
  • insulin
  • KU60648
  • levothyroxine sodium
  • lithium
  • LY294002
  • Norcantharidin
  • NU7441
  • okadaic_acid
  • PD184352
  • PD98059
  • pertuzumab
  • phorbol_ester
  • PP2
  • PRL
  • QLT0267
  • raloxifene
  • rapamycin
  • SB203580
  • seliciclib
  • SERM
  • serum
  • siRNA
  • SP600125
  • SU6656
  • tamoxifen
  • tectoridin
  • TGF-beta
  • THZ1
  • TOT
  • U0126
  • wortmannin
ER-alpha (human) LHPPPQLsPFLQPHG S118-p
ER-alpha (mouse) LHPPPQLsPFLHPHG S122-p
ER-alpha (rat) LHPPPHVsPFLHPHG S123-p
P152
GPPAFYRPNsDNRRQ
1 0
ER-alpha (human) GPPAFYRPNsDNRRQ P152
ER-alpha (mouse) GPPAFYRsNsDNRRQ S156-p
ER-alpha (rat) GPPAFYRSNSDNRRQ S157
S154-p
PAFYRPNsDNRRQGG
Upstream
3 3
Treatment
  • EGF
  • estradiol
ER-alpha (human) PAFYRPNsDNRRQGG S154-p
ER-alpha (mouse) PAFYRsNsDNRRQNG S158-p
ER-alpha (rat) PAFYRSNSDNRRQNG S159
S167-p
GGRERLAsTNDkGSM
Upstream
Downstream
40 5
ER-alpha (human)
S167-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, inhibited
  • cell growth, altered
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
  • AurA (human)
  • CK2A1 (human)
  • IKKE (human)
  • p70S6K (human)
  • p90RSK (human)
Putative in vivo kinases:
  • Akt1 (human)
  • Akt2 (human)
  • AurA (human)
  • IKKE (human)
  • p70S6K (human)
  • p90RSK (human)
  • RSK2 (human)
Regulatory protein:
  • Akt1 (human)
  • AREG (human)
  • EGFR (human)
  • HER2 (human)
  • IGF1R (human)
  • Lmr3 (human)
  • MEMO1 (human)
  • p70S6K (human)
  • p90RSK (human)
  • Ret (human)
  • RSK2 (human)
Treatment
  • 17-beta-estradiol
  • 2-deoxyglucose
  • 3-aminobenzamide
  • 4-HT
  • bisphenol_A
  • BX795
  • catalase
  • EGF
  • estradiol
  • faslodex
  • GDNF
  • glucose_oxidase
  • heregulin
  • IGF-1
  • insulin
  • ischemia
  • LY294002
  • Norcantharidin
  • PD98059
  • phorbol_ester
  • rapamycin
  • SB203580
  • siRNA
  • SP600125
  • SU6656
  • U0126
  • wortmannin
ER-alpha (human) GGRERLAsTNDkGSM S167-p
ER-alpha (mouse) NGRERLSsSNEKGNM S171-p
ER-alpha (rat) NGRERLSSSSEKGNM S172
K171-sm
RLAsTNDkGSMAMES
1 0
ER-alpha (human) RLAsTNDkGSMAMES K171-sm
ER-alpha (mouse) RLSsSNEKGNMIMES K175
ER-alpha (rat) RLSSSSEKGNMIMES K176
K171-ac
RLAsTNDkGSMAMES
1 0
ER-alpha (human) RLAsTNDkGSMAMES K171-ac
ER-alpha (mouse) RLSsSNEKGNMIMES K175
ER-alpha (rat) RLSSSSEKGNMIMES K176
K171-m2
RLAsTNDkGSMAMES
1 0
ER-alpha (human) RLAsTNDkGSMAMES K171-m2
ER-alpha (mouse) RLSsSNEKGNMIMES K175
ER-alpha (rat) RLSSSSEKGNMIMES K176
K171-m1
RLAsTNDkGSMAMES
1 0
ER-alpha (human) RLAsTNDkGSMAMES K171-m1
ER-alpha (mouse) RLSsSNEKGNMIMES K175
ER-alpha (rat) RLSSSSEKGNMIMES K176
K180-sm
SMAMESAkETRYCAV
1 0
ER-alpha (human) SMAMESAkETRYCAV K180-sm
ER-alpha (mouse) NMIMESAKETRYCAV K184
ER-alpha (rat) NMIMESAKETRYCAV K185
K180-m2
SMAMESAkETRYCAV
1 0
ER-alpha (human) SMAMESAkETRYCAV K180-m2
ER-alpha (mouse) NMIMESAKETRYCAV K184
ER-alpha (rat) NMIMESAKETRYCAV K185
S212-p
CKAFFKRsIQGHNDy
Upstream
Downstream
7 1
Effects on Biological Processes:
  • transcription, induced
Treatment
  • estradiol
ER-alpha (human) CKAFFKRsIQGHNDy S212-p
ER-alpha (mouse) CKAFFKRsIQGHNDY S216-p
ER-alpha (rat) CKAFFKRSIQGHNDY S217
Y219-p
sIQGHNDyMCPATNQ
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • Abl (human)
  • IGF1R (human)
Putative in vivo kinases:
  • Abl (human)
  • IGF1R (human)
Regulatory protein:
  • PRMT1 (human)
Treatment
  • imatinib
ER-alpha (human) sIQGHNDyMCPATNQ Y219-p
ER-alpha (mouse) sIQGHNDYMCPATNQ Y223
ER-alpha (rat) SIQGHNDYMCPATNQ Y224
S236-p
IDKNRRKsCQACRLR
Upstream
Downstream
5 1
Effects on Biological Processes:
  • transcription, inhibited
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
Treatment
  • cAMP_analog
  • colforsin
  • estradiol
  • IBMX
ER-alpha (human) IDKNRRKsCQACRLR S236-p
ER-alpha (mouse) IDKNRRKSCQACRLR S240
ER-alpha (rat) IDKNRRKSCQACRLR S241
K244-ac
CQACRLRkCyEVGMM
0 1
ER-alpha (human) CQACRLRkCyEVGMM K244-ac
ER-alpha (mouse) CQACRLRKCYEVGMM K248
ER-alpha (rat) CQACRLRKCyEVGMM K249
Y246-p
ACRLRkCyEVGMMkG
0 2
ER-alpha (human) ACRLRkCyEVGMMkG Y246-p
ER-alpha (mouse) ACRLRKCYEVGMMKG Y250
ER-alpha (rat) ACRLRKCyEVGMMKG Y251-p
K252-ac
CyEVGMMkGGIRKDR
0 1
ER-alpha (human) CyEVGMMkGGIRKDR K252-ac
ER-alpha (mouse) CYEVGMMKGGIRKDR K256
ER-alpha (rat) CyEVGMMKGGIRKDR K257
R260-m2
GGIRKDRrGGRMLkH
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Treatment
  • 17-beta-estradiol
ER-alpha (human) GGIRKDRrGGRMLkH R260-m2
ER-alpha (mouse) GGIRKDRRGGRMLKH R264
ER-alpha (rat) GGIRKDRRGGRMLKH R265
K266-ac
RrGGRMLkHkRQRDD
Upstream
Downstream
3 2
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
Regulatory protein:
  • BRCA1 (human)
Treatment
  • estradiol
ER-alpha (human) RrGGRMLkHkRQRDD K266-ac
ER-alpha (mouse) RRGGRMLKHKRQRDD K270
ER-alpha (rat) RRGGRMLKHKRQRDD K271
K266-sm
RrGGRMLkHkRQRDD
1 0
ER-alpha (human) RrGGRMLkHkRQRDD K266-sm
ER-alpha (mouse) RRGGRMLKHKRQRDD K270
ER-alpha (rat) RRGGRMLKHKRQRDD K271
K266-m1
RrGGRMLkHkRQRDD
1 0
ER-alpha (human) RrGGRMLkHkRQRDD K266-m1
ER-alpha (mouse) RRGGRMLKHKRQRDD K270
ER-alpha (rat) RRGGRMLKHKRQRDD K271
K268-ac
GGRMLkHkRQRDDGE
Upstream
Downstream
3 1
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
Regulatory protein:
  • BRCA1 (human)
Treatment
  • estradiol
ER-alpha (human) GGRMLkHkRQRDDGE K268-ac
ER-alpha (mouse) GGRMLKHKRQRDDLE K272
ER-alpha (rat) GGRMLKHKRQRDDLE K273
K268-sm
GGRMLkHkRQRDDGE
1 0
ER-alpha (human) GGRMLkHkRQRDDGE K268-sm
ER-alpha (mouse) GGRMLKHKRQRDDLE K272
ER-alpha (rat) GGRMLKHKRQRDDLE K273
R277-m2
QRDDGEGrGEVGsAG
1 0
ER-alpha (human) QRDDGEGrGEVGsAG R277-m2
ER-alpha (mouse) QRDDLEGRNEMGAsG R281
ER-alpha (rat) QRDDLEGRNEMGTSG R282
S282-p
EGrGEVGsAGDMRAA
Upstream
Downstream
4 0
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • DMAT
  • estradiol
ER-alpha (human) EGrGEVGsAGDMRAA S282-p
ER-alpha (mouse) EGRNEMGAsGDMRAA A286
ER-alpha (rat) EGRNEMGTSGDMRAA T287
A283
GrGEVGsAGDMRAAN
0 1
ER-alpha (human) GrGEVGsAGDMRAAN A283
ER-alpha (mouse) GRNEMGAsGDMRAAN S287-p
ER-alpha (rat) GRNEMGTSGDMRAAN S288
S294-p
RAANLWPsPLMIkRS
Upstream
Downstream
10 4
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
  • protein conformation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • CDK2 (human)
  • P38A (human)
Putative in vivo kinases:
  • CDK2 (human)
  • P38A (human)
Regulatory protein:
  • SKP2 (human)
Treatment
  • 17-beta-estradiol
  • dinaciclib
  • estradiol
  • MG132
  • palbociclib
  • SB203580
ER-alpha (human) RAANLWPsPLMIkRS S294-p
ER-alpha (mouse) RAANLWPsPLVIKHT S298-p
ER-alpha (rat) RAANLWPSPLVIKHT S299
K299-ac
WPsPLMIkRSkkNsL
2 1
ER-alpha (human) WPsPLMIkRSkkNsL K299-ac
ER-alpha (mouse) WPsPLVIKHTKKNSP K303
ER-alpha (rat) WPSPLVIKHTKKNSP K304
K299-sm
WPsPLMIkRSkkNsL
1 0
ER-alpha (human) WPsPLMIkRSkkNsL K299-sm
ER-alpha (mouse) WPsPLVIKHTKKNSP K303
ER-alpha (rat) WPSPLVIKHTKKNSP K304
K302-ac
PLMIkRSkkNsLALS
Upstream
Downstream
2 0
Effects on Modified Protein
  • activity, induced
Effects on Biological Processes:
  • transcription, altered
Regulatory protein:
  • BRCA1 (human)
ER-alpha (human) PLMIkRSkkNsLALS K302-ac
ER-alpha (mouse) PLVIKHTKKNSPALS K306
ER-alpha (rat) PLVIKHTKKNSPALS K307
K302-ub
PLMIkRSkkNsLALS
Downstream
2 0
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • transcription, altered
ER-alpha (human) PLMIkRSkkNsLALS K302-ub
ER-alpha (mouse) PLVIKHTKKNSPALS K306
ER-alpha (rat) PLVIKHTKKNSPALS K307
K302-m1
PLMIkRSkkNsLALS
2 0
ER-alpha (human) PLMIkRSkkNsLALS K302-m1
ER-alpha (mouse) PLVIKHTKKNSPALS K306
ER-alpha (rat) PLVIKHTKKNSPALS K307
K302-me
PLMIkRSkkNsLALS
1 0
ER-alpha (human) PLMIkRSkkNsLALS K302-me
ER-alpha (mouse) PLVIKHTKKNSPALS K306
ER-alpha (rat) PLVIKHTKKNSPALS K307
K303-ac
LMIkRSkkNsLALSL
Upstream
Downstream
4 1
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
Effects on Biological Processes:
  • transcription, altered
Regulatory protein:
  • BRCA1 (human)
ER-alpha (human) LMIkRSkkNsLALSL K303-ac
ER-alpha (mouse) LVIKHTKKNSPALSL K307
ER-alpha (rat) LVIKHTKKNSPALSL K308
S305-p
IkRSkkNsLALSLtA
Upstream
Downstream
16 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • carcinogenesis, altered
  • carcinogenesis, induced
  • cell growth, altered
  • cell growth, induced
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
  • AurA (human)
  • PAK1 (human)
  • PAK4 (human)
  • PKACA (human)
Putative in vivo kinases:
  • AurA (human)
  • PAK1 (human)
  • PKACA (human)
  • TBK1 (human)
Regulatory protein:
  • AKAP13 (human)
  • IKKE (human)
  • PAK1 (human)
  • PKAR1A (human)
Treatment
  • BX795
  • cAMP_analog
  • colforsin
  • estradiol
  • heregulin
  • peptide inhibitor
  • siRNA
  • tamoxifen
ER-alpha (human) IkRSkkNsLALSLtA S305-p
ER-alpha (mouse) IKHTKKNSPALSLTA S309
ER-alpha (rat) IKHTKKNSPALSLTA S310
T311-p
NsLALSLtADQMVSA
Upstream
Downstream
7 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • P38A (human)
Putative in vivo kinases:
  • P38A (human)
Treatment
  • Auranofin
  • CysNO
  • estradiol
  • SB203580
ER-alpha (human) NsLALSLtADQMVSA T311-p
ER-alpha (mouse) NSPALSLTADQMVSA T315
ER-alpha (rat) NSPALSLTADQMVSA T316
S341-p
TRPFSEAsMMGLLTN
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • cell cycle regulation
  • transcription, induced
Kinase, in vitro:
  • CDK2 (human)
Treatment
  • estradiol
ER-alpha (human) TRPFSEAsMMGLLTN S341-p
ER-alpha (mouse) SRPFSEASMMGLLTN S345
ER-alpha (rat) SRPFSEASMMGLLTN S346
K401-m2
RSMEHPGkLLFAPNL
1 0
ER-alpha (human) RSMEHPGkLLFAPNL K401-m2
ER-alpha (mouse) RSMEHPGKLLFAPNL K405
ER-alpha (rat) RSMEHPGKLLFAPNL K406
S450
EEFVCLKSIILLNSG
0 1
ER-alpha (human) EEFVCLKSIILLNSG S450
ER-alpha (mouse) EEFVCLKSIILLNSG S454
ER-alpha (rat) EEFVCLKsIILLNSG S455-p
T460
LLNSGVYTFLSSTLK
0 1
ER-alpha (human) LLNSGVYTFLSSTLK T460
ER-alpha (mouse) LLNSGVYtFLSsTLK T464-p
ER-alpha (rat) LLNSGVYTFLSsTLK T465
S464
GVYTFLSSTLKSLEE
0 2
ER-alpha (human) GVYTFLSSTLKSLEE S464
ER-alpha (mouse) GVYtFLSsTLKSLEE S468-p
ER-alpha (rat) GVYTFLSsTLKSLEE S469-p
K472-ac
TLKSLEEkDHIHRVL
Upstream
1 1
Treatment
  • estradiol
ER-alpha (human) TLKSLEEkDHIHRVL K472-ac
ER-alpha (mouse) TLKSLEEKDHIHRVL K476
ER-alpha (rat) TLKSLEEKDHIHRVL K477
K472-sm
TLKSLEEkDHIHRVL
1 0
ER-alpha (human) TLKSLEEkDHIHRVL K472-sm
ER-alpha (mouse) TLKSLEEKDHIHRVL K476
ER-alpha (rat) TLKSLEEKDHIHRVL K477
T485-p
VLDKITDtLIHLMAK
0 1
ER-alpha (human) VLDKITDtLIHLMAK T485-p
ER-alpha (mouse) VLDKITDTLIHLMAK T489
ER-alpha (rat) VLDKINDTLIHLMAK T490
Y537-p
CKNVVPLyDLLLEML
Upstream
Downstream
8 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • cell growth, induced
  • transcription, induced
Kinase, in vitro:
  • Lck (human)
  • Src (human)
Phosphatases, in vitro:
  • PTP1B (human)
  • SHP-1 (human)
Treatment
  • colforsin
  • estradiol
  • faslodex
  • IBMX
  • tamoxifen
ER-alpha (human) CKNVVPLyDLLLEML Y537-p
ER-alpha (mouse) CKNVVPLYDLLLEML Y541
ER-alpha (rat) CKNVVPLYDLLLEML Y542
S554-p
HRLHAPTsRGGAsVE
Upstream
1 1
Treatment
  • estradiol
ER-alpha (human) HRLHAPTsRGGAsVE S554-p
ER-alpha (mouse) HRLHAPASRMGVPPE S558
ER-alpha (rat) HRLHAPASRMGVPPE S559
S559-p
PTsRGGAsVEETDQS
Upstream
Downstream
4 1
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • CK2A1 (human)
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • DMAT
  • estradiol
ER-alpha (human) PTsRGGAsVEETDQS S559-p
ER-alpha (mouse) PASRMGVPPEEPSQT P563
ER-alpha (rat) PASRMGVPPEEPSQS P564
A571
DQSHLATAGSTSsHs
2 0
ER-alpha (human) DQSHLATAGSTSsHs A571
ER-alpha (mouse) SQTQLATtSSTSAHS T575-gl
ER-alpha (rat) SQSQLTTTSSTSAHS T576
S576-p
ATAGSTSsHsLQKYY
1 0
ER-alpha (human) ATAGSTSsHsLQKYY S576-p
ER-alpha (mouse) ATtSSTSAHSLQTYY A580
ER-alpha (rat) TTTSSTSAHSLQTYY A581
S578-p
AGSTSsHsLQKYYIT
1 0
ER-alpha (human) AGSTSsHsLQKYYIT S578-p
ER-alpha (mouse) tSSTSAHSLQTYYIP S582
ER-alpha (rat) TSSTSAHSLQTYYIP S583
T594-p
EAEGFPAtV______
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell growth, altered
  • transcription, altered
Treatment
  • fusicoccin
  • MG132
  • phosphorylated peptide
ER-alpha (human) EAEGFPAtV______ T594-p
ER-alpha (mouse) EAEGFPNTI______ T598
ER-alpha (rat) EAEGFPNTI______ T599