Other Species / Isoforms
  SAMHD1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S6-p
__MQRADsEQPSkRP
0 4
SAMHD1 (human) __MQRADsEQPSkRP S6-p
SAMHD1 (mouse) VAMQSAPLEQPAkRP L37
SAMHD1 (rat) __MQRPDSEQPAkRS S6
K11
ADsEQPSKRPRCDDs
0 1
SAMHD1 (human) ADsEQPSKRPRCDDs K11
SAMHD1 (mouse) APLEQPAKRPRCDGs K42
SAMHD1 (rat) PDSEQPAkRSRCDGs K11-ac
K11-ub
ADsEQPSkRPRCDDs
0 3
SAMHD1 (human) ADsEQPSkRPRCDDs K11-ub
SAMHD1 (mouse) APLEQPAkRPRCDGs K42-ub
SAMHD1 (rat) PDSEQPAKRSRCDGs K11
S18-p
kRPRCDDsPRtPsNt
3 62
SAMHD1 (human) kRPRCDDsPRtPsNt S18-p
SAMHD1 (mouse) kRPRCDGsPRtPPst S49-p
SAMHD1 (rat) kRSRCDGsPRtPPST S18-p
T21-p
RCDDsPRtPsNtPsA
4 106
SAMHD1 (human) RCDDsPRtPsNtPsA T21-p
SAMHD1 (mouse) RCDGsPRtPPstPPA T52-p
SAMHD1 (rat) RCDGsPRtPPSTRPA T21-p
S23-p
DDsPRtPsNtPsAEA
0 15
SAMHD1 (human) DDsPRtPsNtPsAEA S23-p
SAMHD1 (mouse) DGsPRtPPstPPAtA P54
SAMHD1 (rat) DGsPRtPPSTRPAAA P23
N24
DsPRtPsNtPsAEAD
1 18
SAMHD1 (human) DsPRtPsNtPsAEAD N24
SAMHD1 (mouse) GsPRtPPstPPAtAN S55-p
SAMHD1 (rat) GsPRtPPSTRPAAAN S24
T25-p
sPRtPsNtPsAEADW
3 45
SAMHD1 (human) sPRtPsNtPsAEADW T25-p
SAMHD1 (mouse) sPRtPPstPPAtANL T56-p
SAMHD1 (rat) sPRtPPSTRPAAANE T25
S27-p
RtPsNtPsAEADWsP
Upstream
0 8
Treatment
  • metastatic potential
SAMHD1 (human) RtPsNtPsAEADWsP S27-p
SAMHD1 (mouse) RtPPstPPAtANLsA P58
SAMHD1 (rat) RtPPSTRPAAANESA P27
E29
PsNtPsAEADWsPGL
0 10
SAMHD1 (human) PsNtPsAEADWsPGL E29
SAMHD1 (mouse) PPstPPAtANLsADD T60-p
SAMHD1 (rat) PPSTRPAAANESADP A29
S33-p
PsAEADWsPGLELHP
Upstream
4 50
Treatment
  • metastatic potential
SAMHD1 (human) PsAEADWsPGLELHP S33-p
SAMHD1 (mouse) PPAtANLsADDDFQN S64-p
SAMHD1 (rat) RPAAANESADPESSD S33
V63
RGGFEEPVLLkNIRE
0 1
SAMHD1 (human) RGGFEEPVLLkNIRE V63
SAMHD1 (mouse) NRGFREKkVLDIFRD K95-ub
SAMHD1 (rat) KRGFREKKVLDIFRE K62
K66-ub
FEEPVLLkNIRENEI
0 10
SAMHD1 (human) FEEPVLLkNIRENEI K66-ub
SAMHD1 (mouse) FREKkVLDIFRDNKI D98
SAMHD1 (rat) FREKKVLDIFRENKI D65
S93-p
FENLGVSsLGERkkL
0 1
SAMHD1 (human) FENLGVSsLGERkkL S93-p
SAMHD1 (mouse) LEDLGVSSLEERKKM S125
SAMHD1 (rat) LESLGVSSLEQRKKM S92
K98-ub
VSsLGERkkLLsyIQ
0 1
SAMHD1 (human) VSsLGERkkLLsyIQ K98-ub
SAMHD1 (mouse) VSSLEERKKMIECIQ K130
SAMHD1 (rat) VSSLEQRKKMIECIQ K97
K99-ub
SsLGERkkLLsyIQR
0 3
SAMHD1 (human) SsLGERkkLLsyIQR K99-ub
SAMHD1 (mouse) SSLEERKKMIECIQQ K131
SAMHD1 (rat) SSLEQRKKMIECIQK K98
S102-p
GERkkLLsyIQRLVQ
0 2
SAMHD1 (human) GERkkLLsyIQRLVQ S102-p
SAMHD1 (mouse) EERKKMIECIQQLSQ E134
SAMHD1 (rat) EQRKKMIECIQKLNQ E101
Y103-p
ERkkLLsyIQRLVQI
0 1
SAMHD1 (human) ERkkLLsyIQRLVQI Y103-p
SAMHD1 (mouse) ERKKMIECIQQLSQS C135
SAMHD1 (rat) QRKKMIECIQKLNQS C102
T138-p
LLVRIIDtPQFQRLR
0 1
SAMHD1 (human) LLVRIIDtPQFQRLR T138-p
SAMHD1 (mouse) LLIRIIDTPQFQRLR T170
SAMHD1 (rat) LLIRIIDTPQFQRLR T137
Y146-p
PQFQRLRyIkQLGGG
Upstream
0 1
Treatment
  • MLN8054
SAMHD1 (human) PQFQRLRyIkQLGGG Y146-p
SAMHD1 (mouse) PQFQRLRYIKQLGGG Y178
SAMHD1 (rat) PQFQRLRYIKQLGGG Y145
K148-ub
FQRLRyIkQLGGGYy
0 1
SAMHD1 (human) FQRLRyIkQLGGGYy K148-ub
SAMHD1 (mouse) FQRLRYIKQLGGGYY K180
SAMHD1 (rat) FQRLRYIKQLGGGYY K147
Y155-p
kQLGGGYyVFPGASH
Upstream
0 1
Treatment
  • MLN8054
SAMHD1 (human) kQLGGGYyVFPGASH Y155-p
SAMHD1 (mouse) KQLGGGYYVFPGASH Y187
SAMHD1 (rat) KQLGGGYYVFPGASH Y154
E255
NGIKPVMEQYGLIPE
0 1
SAMHD1 (human) NGIKPVMEQYGLIPE E255
SAMHD1 (mouse) NELKLVMkNYGLVPE K287-ac
SAMHD1 (rat) NELKLVMKNYGLVPE K254
K269
EEDICFIKEQIVGPL
0 1
SAMHD1 (human) EEDICFIKEQIVGPL K269
SAMHD1 (mouse) EEDITFIkEQIMGPP K301-ub
SAMHD1 (rat) EEDITFIKEQIMGPP K268
S278-p
QIVGPLEsPVEDSLW
Upstream
1 24
Kinase, in vitro:
  • UL97 (herpesvirus)
SAMHD1 (human) QIVGPLEsPVEDSLW S278-p
SAMHD1 (mouse) QIMGPPItPVkDsLW T310-p
SAMHD1 (rat) QIMGPPVsPVKDCLW S277-p
E281
GPLEsPVEDSLWPYk
0 1
SAMHD1 (human) GPLEsPVEDSLWPYk E281
SAMHD1 (mouse) GPPItPVkDsLWPYK K313-ub
SAMHD1 (rat) GPPVsPVKDCLWPYK K280
S283
LEsPVEDSLWPYkGR
0 1
SAMHD1 (human) LEsPVEDSLWPYkGR S283
SAMHD1 (mouse) PItPVkDsLWPYKGR S315-p
SAMHD1 (rat) PVsPVKDCLWPYKGR C282
K288-ub
EDSLWPYkGRPENkS
0 1
SAMHD1 (human) EDSLWPYkGRPENkS K288-ub
SAMHD1 (mouse) kDsLWPYKGRPATKS K320
SAMHD1 (rat) KDCLWPYKGRPAKKS K287
K294-ac
YkGRPENkSFLYEIV
0 1
SAMHD1 (human) YkGRPENkSFLYEIV K294-ac
SAMHD1 (mouse) YKGRPATKSFLYEIV K326
SAMHD1 (rat) YKGRPAKKSFLYEIV K293
K294-ub
YkGRPENkSFLYEIV
Upstream
0 1
Treatment
  • MG132
SAMHD1 (human) YkGRPENkSFLYEIV K294-ub
SAMHD1 (mouse) YKGRPATKSFLYEIV K326
SAMHD1 (rat) YKGRPAKKSFLYEIV K293
K304-ub
LYEIVSNkRNGIDVD
Upstream
0 5
Treatment
  • MG132
SAMHD1 (human) LYEIVSNkRNGIDVD K304-ub
SAMHD1 (mouse) LYEIVSNkRNGIDVD K336-ub
SAMHD1 (rat) LYEIVANKRNGIDVD K303
K312-ub
RNGIDVDkWDyFARD
Upstream
0 3
Treatment
  • MG132
SAMHD1 (human) RNGIDVDkWDyFARD K312-ub
SAMHD1 (mouse) RNGIDVDkWDyFARD K344-ub
SAMHD1 (rat) RNGIDVDKWDYFARD K311
Y315-p
IDVDkWDyFARDCHH
0 3
SAMHD1 (human) IDVDkWDyFARDCHH Y315-p
SAMHD1 (mouse) IDVDkWDyFARDCHH Y347-p
SAMHD1 (rat) IDVDKWDYFARDCHH Y314
K332
IQNNFDYKRFIKFAR
0 1
SAMHD1 (human) IQNNFDYKRFIKFAR K332
SAMHD1 (mouse) IQNNFDYkRFIKFAR K364-ac
SAMHD1 (rat) IQNNFDYKRFIKFAR K331
K332-sm
IQNNFDYkRFIKFAR
0 1
SAMHD1 (human) IQNNFDYkRFIKFAR K332-sm
SAMHD1 (mouse) IQNNFDYKRFIKFAR K364
SAMHD1 (rat) IQNNFDYKRFIKFAR K331
-
gap
0 1
SAMHD1 (human) gap -
SAMHD1 (mouse) RICEVEYkVKEDkTY K378-ub
SAMHD1 (rat) gap -
-
gap
0 1
SAMHD1 (human) gap -
SAMHD1 (mouse) EYkVKEDkTYIRKVK K383-ub
SAMHD1 (rat) gap -
Y360
DKEVGNLYDMFHTRN
0 1
SAMHD1 (human) DKEVGNLYDMFHTRN Y360
SAMHD1 (mouse) EKEVGNLyDMFHTRN Y403-p
SAMHD1 (rat) EKEVGNLYDMFHTRN Y365
T384-p
KVGNIIDtMItDAFL
0 2
SAMHD1 (human) KVGNIIDtMItDAFL T384-p
SAMHD1 (mouse) KISNLIDIMITDAFL I427
SAMHD1 (rat) KIGNLIDIMITEAFL I389
T387-p
NIIDtMItDAFLKAD
0 2
SAMHD1 (human) NIIDtMItDAFLKAD T387-p
SAMHD1 (mouse) NLIDIMITDAFLKAD T430
SAMHD1 (rat) NLIDIMITEAFLKAD T392
K405-ub
EITGAGGkKYRISTA
0 1
SAMHD1 (human) EITGAGGkKYRISTA K405-ub
SAMHD1 (mouse) EITGTAGKKFRISTA K448
SAMHD1 (rat) EITGTEGKKFRISTA K410
Y419-p
AIDDMEAyTKLTDNI
0 1
SAMHD1 (human) AIDDMEAyTKLTDNI Y419-p
SAMHD1 (mouse) AIDDMEAFTKLTDNI F462
SAMHD1 (rat) AIHDMEAFSKLTDNI F424
Y432-p
NIFLEILySTDPKLK
0 1
SAMHD1 (human) NIFLEILySTDPKLK Y432-p
SAMHD1 (mouse) NIFLEVLHSTDPQLS H475
SAMHD1 (rat) NIFLEILYSTDPQLS Y437
K446-ub
KDAREILkQIEYRNL
0 9
SAMHD1 (human) KDAREILkQIEYRNL K446-ub
SAMHD1 (mouse) SEAQSILRNIECRNL R489
SAMHD1 (rat) SEARNILRNIECRNL R451
K455
IEYRNLFKYVGETQP
0 1
SAMHD1 (human) IEYRNLFKYVGETQP K455
SAMHD1 (mouse) IECRNLYkYLGETQP K498-ac
SAMHD1 (rat) IECRNLYKYLGETQP K460
K455-ub
IEYRNLFkYVGETQP
Upstream
0 3
Treatment
  • MG132
SAMHD1 (human) IEYRNLFkYVGETQP K455-ub
SAMHD1 (mouse) IECRNLYkYLGETQP K498-ub
SAMHD1 (rat) IECRNLYKYLGETQP K460
K467-ub
TQPTGQIkIkREDYE
0 1
SAMHD1 (human) TQPTGQIkIkREDYE K467-ub
SAMHD1 (mouse) under review -
SAMHD1 (rat) under review -
K469-sm
PTGQIkIkREDYESL
0 3
SAMHD1 (human) PTGQIkIkREDYESL K469-sm
SAMHD1 (mouse) QPKREKIRKEEYERL R511
SAMHD1 (rat) QPKREKIKKAEYDKL K473
K478-ub
EDYESLPkEVAsAKP
0 1
SAMHD1 (human) EDYESLPkEVAsAKP K478-ub
SAMHD1 (mouse) EEYERLPQEVAKAkP Q520
SAMHD1 (rat) under review -
S482-p
SLPkEVAsAKPkVLL
0 1
SAMHD1 (human) SLPkEVAsAKPkVLL S482-p
SAMHD1 (mouse) RLPQEVAKAkPEKAP K524
SAMHD1 (rat) KLAQEVANAKPEIAP N486
K484
PkEVAsAKPkVLLDV
0 1
SAMHD1 (human) PkEVAsAKPkVLLDV K484
SAMHD1 (mouse) PQEVAKAkPEKAPDV K526-ub
SAMHD1 (rat) AQEVANAKPEIAPDV K488
K486-ub
EVAsAKPkVLLDVKL
0 2
SAMHD1 (human) EVAsAKPkVLLDVKL K486-ub
SAMHD1 (mouse) EVAKAkPEKAPDVEL E528
SAMHD1 (rat) EVANAKPEIAPDVEL E490
Y507-p
VDVINMDyGMQEKNP
0 1
SAMHD1 (human) VDVINMDyGMQEKNP Y507-p
SAMHD1 (mouse) VDVINVDYGMEDKNP Y549
SAMHD1 (rat) VDVINMDYGMEDKNP Y511
S519-p
KNPIDHVsFYCKTAP
0 1
SAMHD1 (human) KNPIDHVsFYCKTAP S519-p
SAMHD1 (mouse) KNPIDRVHFYCKSNS H561
SAMHD1 (rat) KNPIDNVHFYCKSDS H523
K534-ub
NRAIRITkNQVSQLL
0 1
SAMHD1 (human) NRAIRITkNQVSQLL K534-ub
SAMHD1 (mouse) KQAVRINKEQVSQLL K576
SAMHD1 (rat) RQAVTITKDQVSQLL K538
K544
VSQLLPEKFAEQLIR
0 2
SAMHD1 (human) VSQLLPEKFAEQLIR K544
SAMHD1 (mouse) VSQLLPEkFAEQLIR K586-ac
SAMHD1 (rat) VSQLLPQkFAEQLIR K548-ac
K544-ub
VSQLLPEkFAEQLIR
Upstream
0 2
Treatment
  • MG132
SAMHD1 (human) VSQLLPEkFAEQLIR K544-ub
SAMHD1 (mouse) VSQLLPEKFAEQLIR K586
SAMHD1 (rat) VSQLLPQKFAEQLIR K548
Y553-p
AEQLIRVyCKKVDRk
0 1
SAMHD1 (human) AEQLIRVyCKKVDRk Y553-p
SAMHD1 (mouse) AEQLIRVYCKKKDGK Y595
SAMHD1 (rat) AEQLIRVYYKKKDKK Y557
K560-ub
yCKKVDRkSLYAARQ
0 1
SAMHD1 (human) yCKKVDRkSLYAARQ K560-ub
SAMHD1 (mouse) YCKKKDGKSLDAAGK K602
SAMHD1 (rat) YYKKKDKKSLDAAGK K564
T579-p
WCADRNFtKPQDGDV
0 1
SAMHD1 (human) WCADRNFtKPQDGDV T579-p
SAMHD1 (mouse) WCALRDFTKPQDGDI T621
SAMHD1 (rat) WCALRDFTKPQDGDI T583
T592-p
DVIAPLItPQkkEWN
Upstream
Downstream
11 64
SAMHD1 (human)
T592-p
SAMHD1 (mouse)
T634-p
SAMHD1 (rat)
T596-p
Effects on Modified Protein
  • protein conformation
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • UL97 (herpesvirus)
Putative in vivo kinases:
  • CDK1 (human)
  • UL97 (herpesvirus)
Treatment
  • anti-CD3/CD28
  • dasatinib
  • IFN-alpha
  • IFN-beta
  • IL-2
  • IL-7
  • JAK_inhibitor_I
  • phorbol_ester
  • phytohemagglutinin
  • rapamycin
  • virus infection
SAMHD1 (human) DVIAPLItPQkkEWN T592-p
SAMHD1 (mouse) DIIAPLItPLKWNNK T634-p
SAMHD1 (rat) DIIAPLITPLKWNKK T596
K595-sm
APLItPQkkEWNDsT
0 2
SAMHD1 (human) APLItPQkkEWNDsT K595-sm
SAMHD1 (mouse) APLItPLKWNNKTSS K637
SAMHD1 (rat) APLITPLKWNKKTSS K599
K596-ub
PLItPQkkEWNDsTS
0 1
SAMHD1 (human) PLItPQkkEWNDsTS K596-ub
SAMHD1 (mouse) under review -
SAMHD1 (rat) under review -
S601-p
QkkEWNDsTSVQNPt
0 1
SAMHD1 (human) QkkEWNDsTSVQNPt S601-p
SAMHD1 (mouse) tPLKWNNKTSSCLQE K641
SAMHD1 (rat) TPLKWNKKTSSCIEE K603
T608-p
sTSVQNPtRLREASK
0 1
SAMHD1 (human) sTSVQNPtRLREASK T608-p
SAMHD1 (mouse) gap -
SAMHD1 (rat) gap -
S616-p
RLREASKsRVQLFkD
0 2
SAMHD1 (human) RLREASKsRVQLFkD S616-p
SAMHD1 (mouse) SSCLQEVSKVKTCLK S650
SAMHD1 (rat) SSCIEEVSKVKTCLK S612
K622-sm
KsRVQLFkDDPM___
0 2
SAMHD1 (human) KsRVQLFkDDPM___ K622-sm
SAMHD1 (mouse) gap -
SAMHD1 (rat) gap -