Other Species / Isoforms
  BRCA1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K32-ub
PICLELIkEPVSTkC
0 2
BRCA1 (human) PICLELIkEPVSTkC K32-ub
BRCA1 iso6 (human) PICLELIKEPVSTKC K32
BRCA1 iso7 (human) PICLELIKEPVSTKC K32
BRCA1 (mouse) PICLELIKEPVSTKC K32
BRCA1 (rat) PICLELIKEPVSTQC K32
K38-ub
IkEPVSTkCDHIFCK
0 1
BRCA1 (human) IkEPVSTkCDHIFCK K38-ub
BRCA1 iso6 (human) IKEPVSTKCDHIFCK K38
BRCA1 iso7 (human) IKEPVSTKCDHIFCK K38
BRCA1 (mouse) IKEPVSTKCDHIFCK K38
BRCA1 (rat) IKEPVSTQCDHIFCK Q38
K50-ac
FCKFCMLkLLNQKkG
0 1
BRCA1 (human) FCKFCMLkLLNQKkG K50-ac
BRCA1 iso6 (human) FCKFCMLKLLNQKKG K50
BRCA1 iso7 (human) FCKFCMLKLLNQKKG K50
BRCA1 (mouse) FCKFCMLKLLNQKKG K50
BRCA1 (rat) FCKFCMLKLLNQKKG K50
K56-ub
LkLLNQKkGPSQCPL
0 1
BRCA1 (human) LkLLNQKkGPSQCPL K56-ub
BRCA1 iso6 (human) LKLLNQKKGPSQCPL K56
BRCA1 iso7 (human) LKLLNQKKGPSQCPL K56
BRCA1 (mouse) LKLLNQKKGPSQCPL K56
BRCA1 (rat) LKLLNQKKGPSQCPL K56
K65-ub
PSQCPLCkNDITKRS
0 1
BRCA1 (human) PSQCPLCkNDITKRS K65-ub
BRCA1 iso6 (human) PSQCPLCKNDITKRS K65
BRCA1 iso7 (human) PSQCPLCKNDITKRS K65
BRCA1 (mouse) PSQCPLCKNEITKRS K65
BRCA1 (rat) PSQCPLCKNEITKRS K65
K109-sm
ANSYNFAkKENNsPE
0 1
BRCA1 (human) ANSYNFAkKENNsPE K109-sm
BRCA1 iso6 (human) ANSYNFAKKENNSPE K109
BRCA1 iso7 (human) ANSYNFAKKENNSPE K109
BRCA1 (mouse) TNGFSFSKKRNNsCE K109
BRCA1 (rat) ANGFSFSKKKNSSSE K109
S114-p
FAkKENNsPEHLkDE
Upstream
Downstream
1 15
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
Putative in vivo kinases:
  • CDK1 (human)
  • CDK2 (human)
Treatment
  • hydroxyurea
  • RO-3306
  • seliciclib
  • siRNA
BRCA1 (human) FAkKENNsPEHLkDE S114-p
BRCA1 iso6 (human) FAKKENNSPEHLKDE S114
BRCA1 iso7 (human) FAKKENNSPEHLKDE S114
BRCA1 (mouse) FSKKRNNsCERLNEE S114-p
BRCA1 (rat) FSKKKNSSSELLNED S114
K119-sm
NNsPEHLkDEVsIIQ
1 0
BRCA1 (human) NNsPEHLkDEVsIIQ K119-sm
BRCA1 iso6 (human) NNSPEHLKDEVSIIQ K119
BRCA1 iso7 (human) NNSPEHLKDEVSIIQ K119
BRCA1 (mouse) NNsCERLNEEASIIQ N119
BRCA1 (rat) NSSSELLNEDASIIQ N119
S123-p
EHLkDEVsIIQSMGY
0 4
BRCA1 (human) EHLkDEVsIIQSMGY S123-p
BRCA1 iso6 (human) EHLKDEVSIIQSMGY S123
BRCA1 iso7 (human) EHLKDEVSIIQSMGY S123
BRCA1 (mouse) ERLNEEASIIQSVGY S123
BRCA1 (rat) ELLNEDASIIQSVGY S123
T164-p
SNLGTVRtLRTKQRI
0 1
BRCA1 (human) SNLGTVRtLRTKQRI T164-p
BRCA1 iso6 (human) SNLGTVRTLRTKQRI T164
BRCA1 iso7 (human) SNLGTVRTLRTKQRI T164
BRCA1 (mouse) SNLGIVRSVKKNRQT S163
BRCA1 (rat) SNLGIVRSMKKNRQT S163
S184-p
SVYIELGsDssEDTV
0 2
BRCA1 (human) SVYIELGsDssEDTV S184-p
BRCA1 iso6 (human) SVYIELGSDSSEDTV S184
BRCA1 iso7 (human) SVYIELGSDSSEDTV S184
BRCA1 (mouse) SVYIELDsDssEETV S183-p
BRCA1 (rat) SVYIALESDSSEERV S183
S186-p
YIELGsDssEDTVNK
0 2
BRCA1 (human) YIELGsDssEDTVNK S186-p
BRCA1 iso6 (human) YIELGSDSSEDTVNK S186
BRCA1 iso7 (human) YIELGSDSSEDTVNK S186
BRCA1 (mouse) YIELDsDssEETVTK S185-p
BRCA1 (rat) YIALESDSSEERVNA S185
S187-p
IELGsDssEDTVNKA
0 2
BRCA1 (human) IELGsDssEDTVNKA S187-p
BRCA1 iso6 (human) IELGSDSSEDTVNKA S187
BRCA1 iso7 (human) IELGSDSSEDTVNKA S187
BRCA1 (mouse) IELDsDssEETVTKP S186-p
BRCA1 (rat) IALESDSSEERVNAP S186
T208-p
DQELLQItPQGTRDE
0 7
BRCA1 (human) DQELLQItPQGTRDE T208-p
BRCA1 iso6 (human) DQELLQITPQGTRDE T208
BRCA1 iso7 (human) DQELLQITPQGTRDE T208
BRCA1 (mouse) DQELLQTAPQEAGDE A207
BRCA1 (rat) DQELFQIAPGGAGDE A207
S220-p
RDEISLDsAKkAACE
0 2
BRCA1 (human) RDEISLDsAKkAACE S220-p
BRCA1 iso6 (human) RDEISLDSAKKAACE S220
BRCA1 iso7 (human) RDEISLDSAKKAACE S220
BRCA1 (mouse) GDEGKLHSAEEAACE S219
BRCA1 (rat) GDEGKLNSAKKAACD S219
K223-ub
ISLDsAKkAACEFSE
0 1
BRCA1 (human) ISLDsAKkAACEFSE K223-ub
BRCA1 iso6 (human) ISLDSAKKAACEFSE K223
BRCA1 iso7 (human) ISLDSAKKAACEFSE K223
BRCA1 (mouse) GKLHSAEEAACEFSE E222
BRCA1 (rat) GKLNSAKKAACDFSE K222
K294-ub
NSSLLLTkDRMNVEK
0 1
BRCA1 (human) NSSLLLTkDRMNVEK K294-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) NSSLLLTKDRMNVEK K294
BRCA1 (mouse) TSSLLLIEDRMNAEK E291
BRCA1 (rat) under review -
S308-p
KAEFCNKskQPGLAR
Upstream
Downstream
2 0
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • AurA (human)
Putative in vivo kinases:
  • AurA (human)
BRCA1 (human) KAEFCNKskQPGLAR S308-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KAEFCNKSKQPGLAR S308
BRCA1 (mouse) KAEFCNKSKQPGIAV S305
BRCA1 (rat) KAEFCDRSKQSGAAV S306
K309-ub
AEFCNKskQPGLARS
0 1
BRCA1 (human) AEFCNKskQPGLARS K309-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) AEFCNKSKQPGLARS K309
BRCA1 (mouse) AEFCNKSKQPGIAVs K306
BRCA1 (rat) AEFCDRSKQSGAAVS K307
S316
kQPGLARSQHNRWAG
0 5
BRCA1 (human) kQPGLARSQHNRWAG S316
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KQPGLARSQHNRWAG S316
BRCA1 (mouse) KQPGIAVsQQSRWAA S313-p
BRCA1 (rat) KQSGAAVSQQSRWAD S314
K339-sm
RTPSTEKkVDLNADP
0 1
BRCA1 (human) RTPSTEKkVDLNADP K339-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) RTPSTEKKVDLNADP K339
BRCA1 (mouse) QVPSTGEKVGPNADS K336
BRCA1 (rat) PVPRTEGKADPNVDS K337
K357-ub
RKEWNKQkLPCSENP
0 1
BRCA1 (human) RKEWNKQkLPCSENP K357-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) RKEWNKQKLPCSENP K357
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
S395-p
RSDELLGsDDsHDGE
0 13
BRCA1 (human) RSDELLGsDDsHDGE S395-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) RSDELLGSDDSHDGE S395
BRCA1 (mouse) RTGEMLTSDSASARR S392
BRCA1 (rat) RTGEMLTSDNASDRR S393
S398-p
ELLGsDDsHDGEsES
0 13
BRCA1 (human) ELLGsDDsHDGEsES S398-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) ELLGSDDSHDGESES S398
BRCA1 (mouse) MLTSDSASARRHESN S396
BRCA1 (rat) MLTSDNASDRRPASN S397
S403-p
DDsHDGEsESNAKVA
0 4
BRCA1 (human) DDsHDGEsESNAKVA S403-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) DDSHDGESESNAKVA S403
BRCA1 (mouse) DSASARRHESNAEAA H400
BRCA1 (rat) DNASDRRPASNAEAA P401
S423-p
LNEVDEYsGssEkID
0 5
BRCA1 (human) LNEVDEYsGssEkID S423-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LNEVDEYSGSSEKID S423
BRCA1 (mouse) NEVDGGFSSSRKTDL S421
BRCA1 (rat) NEVDGCFSSSKKIDL S422
S425-p
EVDEYsGssEkIDLL
0 2
BRCA1 (human) EVDEYsGssEkIDLL S425-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) EVDEYSGSSEKIDLL S425
BRCA1 (mouse) EVDGGFSSSRKTDLV S422
BRCA1 (rat) EVDGCFSSSKKIDLV S423
S426-p
VDEYsGssEkIDLLA
0 3
BRCA1 (human) VDEYsGssEkIDLLA S426-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) VDEYSGSSEKIDLLA S426
BRCA1 (mouse) VDGGFSSSRKTDLVT S423
BRCA1 (rat) VDGCFSSSKKIDLVA S424
K428-ub
EYsGssEkIDLLAsD
0 1
BRCA1 (human) EYsGssEkIDLLAsD K428-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) EYSGSSEKIDLLASD K428
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
S434-p
EkIDLLAsDPHEALI
0 6
BRCA1 (human) EkIDLLAsDPHEALI S434-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) EKIDLLASDPHEALI S434
BRCA1 (mouse) SRKTDLVTPDPHHTL T430
BRCA1 (rat) SKKIDLVAPDPDNAV A431
K443-sm
PHEALICkSERVHSk
0 1
BRCA1 (human) PHEALICkSERVHSk K443-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) PHEALICKSERVHSK K443
BRCA1 (mouse) PHHTLMCKSGRDFSK K440
BRCA1 (rat) PDNAVMCTSGRDFSK T441
K443-ub
PHEALICkSERVHSk
0 1
BRCA1 (human) PHEALICkSERVHSk K443-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) PHEALICKSERVHSK K443
BRCA1 (mouse) PHHTLMCKSGRDFSK K440
BRCA1 (rat) under review -
K450-ub
kSERVHSksVEsNIE
0 2
BRCA1 (human) kSERVHSksVEsNIE K450-ub
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KSERVHSKSVESNIE K450
BRCA1 (mouse) KSGRDFSKPVEDNIs K447
BRCA1 (rat) TSGRDFSKPVENIIN K448
S451-p
SERVHSksVEsNIED
0 3
BRCA1 (human) SERVHSksVEsNIED S451-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) SERVHSKSVESNIED S451
BRCA1 (mouse) SGRDFSKPVEDNIsD P448
BRCA1 (rat) SGRDFSKPVENIIND P449
S454-p
VHSksVEsNIEDkIF
0 2
BRCA1 (human) VHSksVEsNIEDkIF S454-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) VHSKSVESNIEDKIF S454
BRCA1 (mouse) DFSKPVEDNIsDKIF D451
BRCA1 (rat) DFSKPVENIINDKIF N452
E457
ksVEsNIEDkIFGkT
0 1
BRCA1 (human) ksVEsNIEDkIFGkT E457
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KSVESNIEDKIFGKT E457
BRCA1 (mouse) KPVEDNIsDKIFGKS S454-p
BRCA1 (rat) KPVENIINDKIFGKT N455
K459-sm
VEsNIEDkIFGkTYR
0 1
BRCA1 (human) VEsNIEDkIFGkTYR K459-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) VESNIEDKIFGKTYR K459
BRCA1 (mouse) VEDNIsDKIFGKSYQ K456
BRCA1 (rat) VENIINDKIFGKTYQ K457
K459-ub
VEsNIEDkIFGkTYR
0 1
BRCA1 (human) VEsNIEDkIFGkTYR K459-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) VESNIEDKIFGKTYR K459
BRCA1 (mouse) VEDNIsDKIFGKSYQ K456
BRCA1 (rat) VENIINDKIFGKTYQ K457
K463-ub
IEDkIFGkTYRKKAS
0 1
BRCA1 (human) IEDkIFGkTYRKKAS K463-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) IEDKIFGKTYRKKAS K463
BRCA1 (mouse) IsDKIFGKSYQRKGS K460
BRCA1 (rat) INDKIFGKTYQRKGS K461
T509-p
LKRKRRPtsGLHPED
Upstream
Downstream
3 79
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • heregulin
  • LY294002
  • neuregulin
  • PD98059
BRCA1 (human) LKRKRRPtsGLHPED T509-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LKRKRRPTSGLHPED T509
BRCA1 (mouse) NKLKRKRstsLQPED S502-p
BRCA1 (rat) NKLKRKRSTCLHPED S503
S510-p
KRKRRPtsGLHPEDF
0 8
BRCA1 (human) KRKRRPtsGLHPEDF S510-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KRKRRPTSGLHPEDF S510
BRCA1 (mouse) KLKRKRstsLQPEDF T503-p
BRCA1 (rat) KLKRKRSTCLHPEDF T504
G511
RKRRPtsGLHPEDFI
0 3
BRCA1 (human) RKRRPtsGLHPEDFI G511
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) RKRRPTSGLHPEDFI G511
BRCA1 (mouse) LKRKRstsLQPEDFI S504-p
BRCA1 (rat) LKRKRSTCLHPEDFI C505
K519-ub
LHPEDFIkKADLAVQ
0 1
BRCA1 (human) LHPEDFIkKADLAVQ K519-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) LHPEDFIKKADLAVQ K519
BRCA1 (mouse) LQPEDFIKKADSAGV K512
BRCA1 (rat) LHPEDFIKKADLTVV K513
S551-p
QVMNITNsGHENKTK
0 3
BRCA1 (human) QVMNITNsGHENKTK S551-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) QVMNITNSGHENKTK S551
BRCA1 (mouse) EQAVSTTSNCQENKI S544
BRCA1 (rat) DQAMSITSNGQENRA S545
K566-ub
GDSIQNEkNPNPIES
0 1
BRCA1 (human) GDSIQNEkNPNPIES K566-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) GDSIQNEKNPNPIES K566
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
K576-ub
NPIESLEkESAFKTk
0 1
BRCA1 (human) NPIESLEkESAFKTk K576-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) NPIESLEKESAFKTK K576
BRCA1 (mouse) under review -
BRCA1 (rat) HPIESLRKEPAFTAK K571
K583-sm
kESAFKTkAEPISSS
0 1
BRCA1 (human) kESAFKTkAEPISSS K583-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KESAFKTKAEPISSS K583
BRCA1 (mouse) KEPASTAGAKSISNS G577
BRCA1 (rat) KEPAFTAKAKSISNS K578
S615-p
KNRLRRKsstRHIHA
0 36
BRCA1 (human) KNRLRRKsstRHIHA S615-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KNRLRRKSSTRHIHA S615
BRCA1 (mouse) KNRLRRKSSIRCALP S609
BRCA1 (rat) KNRLRRKSTRCVLPL S610
S616-p
NRLRRKsstRHIHAL
0 36
BRCA1 (human) NRLRRKsstRHIHAL S616-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) NRLRRKSSTRHIHAL S616
BRCA1 (mouse) NRLRRKSSIRCALPL S610
BRCA1 (rat) NRLRRKSTRCVLPLE T611
T617-p
RLRRKsstRHIHALE
0 5
BRCA1 (human) RLRRKsstRHIHALE T617-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) RLRRKSSTRHIHALE T617
BRCA1 (mouse) RLRRKSSIRCALPLE I611
BRCA1 (rat) gap -
S632-p
LVVSRNLsPPNCTEL
Upstream
Downstream
1 3
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • CDK4 (human)
Putative in vivo kinases:
  • CDK4 (human)
Treatment
  • fascaplysin
  • siRNA
BRCA1 (human) LVVSRNLsPPNCTEL S632-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LVVSRNLSPPNCTEL S632
BRCA1 (mouse) EPISRNPsPPTCAEL S625-p
BRCA1 (rat) EPISRNPSPPTCAEL S625
S647-p
QIDSCSSsEEIKKKk
0 1
BRCA1 (human) QIDSCSSsEEIKKKk S647-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) QIDSCSSSEEIKKKK S647
BRCA1 (mouse) QIDsCGSSEEtKKNH S640
BRCA1 (rat) QIESCGSSEETKKNN S640
K654-sm
sEEIKKKkYNQMPVR
0 1
BRCA1 (human) sEEIKKKkYNQMPVR K654-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) SEEIKKKKYNQMPVR K654
BRCA1 (mouse) SEEtKKNHSNQQPAG H647
BRCA1 (rat) SEETKKNNSNQTPAG N647
S694-p
QTSKRHDsDTFPELk
Upstream
Downstream
1 22
Effects on Modified Protein
  • protein stabilization
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • estradiol
  • IGF-1
BRCA1 (human) QTSKRHDsDTFPELk S694-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) QTSKRHDSDTFPELK S694
BRCA1 (mouse) HIRKRRAsDAFPEEK S686-p
BRCA1 (rat) HIRKRSASDAFPEEK S686
K701-ub
sDTFPELkLTNAPGs
0 1
BRCA1 (human) sDTFPELkLTNAPGs K701-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) SDTFPELKLTNAPGS K701
BRCA1 (mouse) sDAFPEEKLMNKAGL K693
BRCA1 (rat) SDAFPEEKLMNKAGL K693
S708-p
kLTNAPGsFTkCSNT
0 2
BRCA1 (human) kLTNAPGsFTkCSNT S708-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KLTNAPGSFTKCSNT S708
BRCA1 (mouse) KLMNKAGLLTsCssP L700
BRCA1 (rat) KLMNKAGLLTSCSSP L700
K711
NAPGsFTKCSNTSEL
0 1
BRCA1 (human) NAPGsFTKCSNTSEL K711
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) NAPGSFTKCSNTSEL K711
BRCA1 (mouse) NKAGLLTsCssPRKs S703-p
BRCA1 (rat) NKAGLLTSCSSPRKP S703
K711-ub
NAPGsFTkCSNTSEL
0 1
BRCA1 (human) NAPGsFTkCSNTSEL K711-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) NAPGSFTKCSNTSEL K711
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
S713
PGsFTkCSNTSELKE
0 2
BRCA1 (human) PGsFTkCSNTSELKE S713
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) PGSFTKCSNTSELKE S713
BRCA1 (mouse) AGLLTsCssPRKsQG S705-p
BRCA1 (rat) AGLLTSCSSPRKPQG S705
N714
GsFTkCSNTSELKEF
0 6
BRCA1 (human) GsFTkCSNTSELKEF N714
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) GSFTKCSNTSELKEF N714
BRCA1 (mouse) GLLTsCssPRKsQGP S706-p
BRCA1 (rat) GLLTSCSSPRKPQGP S706
L718
kCSNTSELKEFVNPS
0 3
BRCA1 (human) kCSNTSELKEFVNPS L718
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KCSNTSELKEFVNPS L718
BRCA1 (mouse) sCssPRKsQGPVNPs S710-p
BRCA1 (rat) SCSSPRKPQGPVNPs P710
S725
LKEFVNPSLPREEKE
0 6
BRCA1 (human) LKEFVNPSLPREEKE S725
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LKEFVNPSLPREEKE S725
BRCA1 (mouse) sQGPVNPsPQRTGTE S717-p
BRCA1 (rat) PQGPVNPsPERKGIE S717-p
K734-sm
PREEKEEkLETVkVs
0 1
BRCA1 (human) PREEKEEkLETVkVs K734-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) PREEKEEKLETVKVS K734
BRCA1 (mouse) PQRTGTEQLETRQMS Q725
BRCA1 (rat) PERKGIEQLEMCQMP Q725
K739-sm
EEkLETVkVsNNAED
0 1
BRCA1 (human) EEkLETVkVsNNAED K739-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) EEKLETVKVSNNAED K739
BRCA1 (mouse) TEQLETRQMSDSAKE Q730
BRCA1 (rat) IEQLEMCQMPDNNKE Q730
S741-p
kLETVkVsNNAEDPk
0 1
BRCA1 (human) kLETVkVsNNAEDPk S741-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) KLETVKVSNNAEDPK S741
BRCA1 (mouse) QLETRQMSDSAKELG S732
BRCA1 (rat) QLEMCQMPDNNKELG P732
K748-ub
sNNAEDPkDLMLsGE
0 1
BRCA1 (human) sNNAEDPkDLMLsGE K748-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) SNNAEDPKDLMLSGE K748
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
S753-p
DPkDLMLsGERVLQT
0 9
BRCA1 (human) DPkDLMLsGERVLQT S753-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) DPKDLMLSGERVLQT S753
BRCA1 (mouse) ELGDRVLGGEPSGKT G744
BRCA1 (rat) ELGDLVLGGEPSGKP G744
S803-p
TEPNKCVsQCAAFEN
0 6
BRCA1 (human) TEPNKCVsQCAAFEN S803-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) TEPNKCVSQCAAFEN S803
BRCA1 (mouse) TGSAQCMTQFVASEN T795
BRCA1 (rat) TGSVQCMTQFVASEN T795
K820-ub
GLIHGCSkDNRNDTE
0 1
BRCA1 (human) GLIHGCSkDNRNDTE K820-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) GLIHGCSKDNRNDTE K820
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
K830-ub
RNDTEGFkYPLGHEV
0 1
BRCA1 (human) RNDTEGFkYPLGHEV K830-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) RNDTEGFKYPLGHEV K830
BRCA1 (mouse) under review -
BRCA1 (rat) under review -
S840
LGHEVNHSRETSIEM
0 4
BRCA1 (human) LGHEVNHSRETSIEM S840
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LGHEVNHSRETSIEM S840
BRCA1 (mouse) LRHALNLsQEKVEME S831-p
BRCA1 (rat) LRHELNHNQETIEME N831
S868-p
FKVSKRQsFAPFSNP
0 2
BRCA1 (human) FKVSKRQsFAPFSNP S868-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) FKVSKRQSFAPFSNP S868
BRCA1 (mouse) FQVSKRQsFALFSKP S858-p
BRCA1 (rat) FQVSKRQSFALFSKL S858
K918-sm
GKNESNIkPVQTVNI
0 1
BRCA1 (human) GKNESNIkPVQTVNI K918-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) GKNESNIKPVQTVNI K918
BRCA1 (mouse) GQEEFEISHVQAVAA S903
BRCA1 (rat) GQEESEISHVQAVTV S907
G960
CLSSQFRGNETGLIt
0 1
BRCA1 (human) CLSSQFRGNETGLIt G960
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) CLSSQFRGNETGLIT G960
BRCA1 (mouse) CPSSHYRsGENGLSA S943-p
BRCA1 (rat) CPSSHYRSCENGLNT S947
T967-p
GNETGLItPNkHGLL
0 7
BRCA1 (human) GNETGLItPNkHGLL T967-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) GNETGLITPNKHGLL T967
BRCA1 (mouse) GENGLSATGKSGISQ T951
BRCA1 (rat) CENGLNTTDKSGISQ T955
K970-ub
TGLItPNkHGLLQNP
0 1
BRCA1 (human) TGLItPNkHGLLQNP K970-ub
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) TGLITPNKHGLLQNP K970
BRCA1 (mouse) NGLSATGKSGISQNS K953
BRCA1 (rat) NGLNTTDKSGISQNS K957
Y978-p
HGLLQNPyRIPPLFP
0 1
BRCA1 (human) HGLLQNPyRIPPLFP Y978-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) HGLLQNPYRIPPLFP Y978
BRCA1 (mouse) SGISQNSHFKQSVSP H961
BRCA1 (rat) SGISQNSHFRQSVSP H965
K987-ub
IPPLFPIksFVKTKC
0 1
BRCA1 (human) IPPLFPIksFVKTKC K987-ub
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) IPPLFPIKSFVKTKC K987
BRCA1 (mouse) KQSVSPIRsSIKTDN R970
BRCA1 (rat) RQSVSPLRSSIKTDN R974
S988-p
PPLFPIksFVKTKCK
Upstream
Downstream
6 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Kinase, in vitro:
  • Chk2 (human)
Putative in vivo kinases:
  • Chk2 (human)
Putative upstream phosphatases:
  • PPP6C (human)
Treatment
  • ionizing_radiation
  • UV
BRCA1 (human) PPLFPIksFVKTKCK S988-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) PPLFPIKSFVKTKCK S988
BRCA1 (mouse) QSVSPIRsSIKTDNR S971-p
BRCA1 (rat) QSVSPLRSSIKTDNR S975
S1007-p
EENFEEHsMsPEREM
0 3
BRCA1 (human) EENFEEHsMsPEREM S1007-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) EENFEEHSMSPEREM S1007
BRCA1 (mouse) EGRFERHTSSTEMAV T990
BRCA1 (rat) EGRFEKHTERGMGNE T994
S1009-p
NFEEHsMsPEREMGN
0 7
BRCA1 (human) NFEEHsMsPEREMGN S1009-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) NFEEHSMSPEREMGN S1009
BRCA1 (mouse) RFERHTSSTEMAVGN S992
BRCA1 (rat) gap -
S1050-p
NINEVGSsTNEVGSS
0 1
BRCA1 (human) NINEVGSsTNEVGSS S1050-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) NINEVGSSTNEVGSS S1050
BRCA1 (mouse) gap -
BRCA1 (rat) gap -
K1079-ac
LGRNRGPkLNAMLRL
0 2
BRCA1 (human) LGRNRGPkLNAMLRL K1079-ac
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LGRNRGPKLNAMLRL K1079
BRCA1 (mouse) LGRNRGPKVNTVPPL K1048
BRCA1 (rat) LDRNRGPKVNTVSLL K1049
K1079-sm
LGRNRGPkLNAMLRL
0 1
BRCA1 (human) LGRNRGPkLNAMLRL K1079-sm
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) LGRNRGPKLNAMLRL K1079
BRCA1 (mouse) LGRNRGPKVNTVPPL K1048
BRCA1 (rat) LDRNRGPKVNTVSLL K1049
S1101-p
YKQSLPGsNCKHPEI
0 1
BRCA1 (human) YKQSLPGsNCKHPEI S1101-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) YKQSLPGSNCKHPEI S1101
BRCA1 (mouse) CQQSVPVSDKYLEIK S1070
BRCA1 (rat) SKQSAPVSDkYLEIK S1071
K1104
SLPGsNCKHPEIKKQ
0 1
BRCA1 (human) SLPGsNCKHPEIKKQ K1104
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) SLPGSNCKHPEIKKQ K1104
BRCA1 (mouse) QSVPVSDKYLEIKKQ K1072
BRCA1 (rat) QSAPVSDkYLEIKQE K1073-ac
S1143-p
PMGSSHAsQVCSETP
Upstream
Downstream
2 0
Effects on Modified Protein
  • intracellular localization
Kinase, in vitro:
  • ATR (human)
BRCA1 (human) PMGSSHAsQVCSETP S1143-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) PMGSSHASQVCSETP S1143
BRCA1 (mouse) QSMSGKVFQVCSETP F1106
BRCA1 (rat) PMRSDKTFQVCSETP F1107
S1164-p
GEIKEDTsFAENDIk
Upstream
Downstream
1 2
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • DNA repair, induced
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
Treatment
  • BI2536
BRCA1 (human) GEIKEDTsFAENDIk S1164-p
BRCA1 iso6 (human) gap -
BRCA1 iso7 (human) GEIKEDTSFAENDIK S1164
BRCA1 (mouse) VEIQGHTSFGEGDIM S1127
BRCA1 (rat) VEIQENASFGEGGIT S1128
K1171-ub
sFAENDIkESsAVFs
0 1
BRCA1 (human) sFAENDIkESsAVFs K1171-ub
BRCA1 iso6 (human) under review -
BRCA1 iso7 (human) SFAENDIKESSAVFS K1171