Other Species / Isoforms
  Bcl-2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y9-p
AHAGRTGyDNREIVM
0 1
Bcl-2 (human) AHAGRTGyDNREIVM Y9-p
Bcl-2 (mouse) AQAGRTGYDNREIVM Y9
Bcl-2 (rat) AQAGRTGYDNREIVM Y9
K22-ub
VMKYIHYkLSQRGYE
1 1
Bcl-2 (human) VMKYIHYkLSQRGYE K22-ub
Bcl-2 (mouse) VMKYIHYKLSQRGYE K22
Bcl-2 (rat) VMKYIHYKLsQRGYE K22
S24
KYIHYkLSQRGYEWD
1 0
Bcl-2 (human) KYIHYkLSQRGYEWD S24
Bcl-2 (mouse) KYIHYKLSQRGYEWD S24
Bcl-2 (rat) KYIHYKLsQRGYEWD S24-p
T56-p
FSSQPGHtPHPAASR
Upstream
Downstream
11 1
Bcl-2 (human)
T56-p
Effects on Modified Protein
  • molecular association, regulation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • cell cycle regulation
Kinase, in vitro:
  • CDK1 (human)
  • ERK1 (human)
  • JNK3 (mouse)
  • P38A (human)
Putative in vivo kinases:
  • CDK1 (human)
  • ERK2 (human)
  • P38A (human)
Regulatory protein:
  • JNK3 (mouse)
  • LKB1 (human)
  • RAC1 (human)
Treatment
  • ABT-737
  • K252a
  • okadaic_acid
  • SB203580
  • siRNA
  • virus infection
Bcl-2 (human) FSSQPGHtPHPAASR T56-p
Bcl-2 (mouse) FSFQPESNPMPAVHR N56
Bcl-2 (rat) FSFQPESNRTPAVHR N56
T69-p
SRDPVARtsPLQtPA
Upstream
Downstream
8 0
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, inhibited
Putative in vivo kinases:
  • JNK1 (human)
Regulatory protein:
  • JNK1 (human)
Treatment
  • amino_acid_starvation
  • C2-ceramide
  • C2-DHCer
  • cisplatin
  • nicotine
  • taxol
Bcl-2 (human) SRDPVARtsPLQtPA T69-p
Bcl-2 (mouse) HRDMAARtsPLRPLV T69-p
Bcl-2 (rat) HRDTAARTsPLRPLV T69
S70-p
RDPVARtsPLQtPAA
Upstream
Downstream
39 1
Bcl-2 (human)
S70-p
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
  • cell cycle regulation
  • cell growth, altered
Kinase, in vitro:
  • JNK1 (human)
  • JNK3 (mouse)
  • PKCA (human)
Putative in vivo kinases:
  • JNK1 (human)
  • PKCA (human)
  • PKCD (human)
Regulatory protein:
  • caveolin-1 (human)
  • ID1 (human)
  • JNK1 (human)
  • JNK3 (mouse)
  • LKB1 (human)
  • RAC1 (human)
  • TSC2 (human)
Treatment
  • ABT-737
  • allyl isothiocyanate
  • amino_acid_starvation
  • C2-ceramide
  • C2-DHCer
  • ceramide
  • cisplatin
  • docetaxel
  • dolastatin_10
  • ET18OCH3
  • etoposide
  • geldanamycin
  • heating
  • hexamethionium
  • hydroxyurea
  • Hypericin
  • light
  • nicotine
  • nitric_oxide
  • okadaic_acid
  • PD98059
  • photodynamic therapy
  • plumbagin
  • rapamycin
  • SB202190
  • siRNA
  • SP600125
  • staurosporine
  • taxol
  • testosterone
  • vinblastine
  • vincristine
  • virus infection
Bcl-2 (human) RDPVARtsPLQtPAA S70-p
Bcl-2 (mouse) RDMAARtsPLRPLVA S70-p
Bcl-2 (rat) RDTAARTsPLRPLVA S70-p
T74-p
ARtsPLQtPAAPGAA
Upstream
Downstream
4 0
Effects on Modified Protein
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
Kinase, in vitro:
  • ERK1 (human)
  • JNK3 (mouse)
Putative in vivo kinases:
  • ERK2 (human)
Regulatory protein:
  • JNK3 (mouse)
  • RAC1 (human)
Bcl-2 (human) ARtsPLQtPAAPGAA T74-p
Bcl-2 (mouse) ARtsPLRPLVATAGP P74
Bcl-2 (rat) ARTsPLRPLVANAGP P74
S87-p
AAAGPALsPVPPVVH
Upstream
Downstream
19 1
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein conformation
  • protein stabilization
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, altered
  • apoptosis, induced
  • apoptosis, inhibited
Kinase, in vitro:
  • ERK1 (human)
  • ERK2 (human)
  • JNK1 (human)
  • JNK3 (mouse)
  • P38A (human)
Putative in vivo kinases:
  • ERK2 (human)
  • JNK1 (human)
  • P38A (human)
Regulatory protein:
  • JNK1 (human)
  • JNK3 (mouse)
  • PXN (human)
  • RAC1 (human)
Treatment
  • amino_acid_starvation
  • C2-ceramide
  • C2-DHCer
  • cisplatin
  • geldanamycin
  • K252a
  • nicotine
  • PD98059
  • SB203580
  • selumetinib
  • taxol
  • TNF
  • U0126
  • virus infection
Bcl-2 (human) AAAGPALsPVPPVVH S87-p
Bcl-2 (mouse) ATAGPALsPVPPVVH S84-p
Bcl-2 (rat) ANAGPALsPVPPVVH S84-p
Y235-p
ACITLGAyLGHK___
0 1
Bcl-2 (human) ACITLGAyLGHK___ Y235-p
Bcl-2 (mouse) ACITLGAYLGHK___ Y232
Bcl-2 (rat) ACITLGAYLGHK___ Y232