Other Species / Isoforms mouse rat

ATF-2 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

T52-p

HKHKHEMtLKFGPAR

Upstream

Downstream

2

1

Effects on Modified Protein

intracellular localization

Effects on Biological Processes:

apoptosis, inhibited
carcinogenesis, induced
cell adhesion, inhibited
cell growth, induced
cell motility, induced
transcription, induced
transcription, inhibited

Kinase, in vitro:

PKCE (human)

Putative in vivo kinases:

PKCE (human)

ATF-2 (human)	HKHKHEMtLKFGPAR	T52-p
ATF-2 (mouse)	HKHKHEMTLKFGPAR	T34
ATF-2 (rat)	HKHKHEMTLKFGPAR	T34

S62-p

FGPARNDsVIVADQt

Upstream

Downstream

2

38

Effects on Modified Protein

activity, induced
protein stabilization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

PKACA (cow)
VRK1 (human)

Putative in vivo kinases:

VRK1 (human)

ATF-2 (human)	FGPARNDsVIVADQt	S62-p
ATF-2 (mouse)	FGPARNDsVIVADQt	S44-p
ATF-2 (rat)	FGPARNDSVIVADQt	S44

T69-p

sVIVADQtPtPtRFL

Upstream

Downstream

32

106

ATF-2 (human)
T69-p

ATF-2 (mouse)
T51-p

ATF-2 (rat)
T51-p

Effects on Modified Protein

activity, induced
enzymatic activity, induced
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

cell cycle regulation
cell motility, induced
signaling pathway regulation
transcription, altered
transcription, induced

Kinase, in vitro:

ERK1 (human)
JNK1 (human)
JNK2 (human)
P38A (human)
P38A (mouse)
P38B (human)
PLK3 (human)

Putative in vivo kinases:

JNK1 (human)
JNK2 (human)
P38A (human)
P38B (human)

Regulatory protein:

Akt1 (human)
CAMK4 (human)
DVL1 (human)
Ku70 (human)
Myc (human)
RALA (human)
TMEM88 (human)

Treatment

ATF-2 (human)	sVIVADQtPtPtRFL	T69-p
ATF-2 (mouse)	sVIVADQtPtPtRFL	T51-p
ATF-2 (rat)	SVIVADQtPtPtRFL	T51-p

T71-p

IVADQtPtPtRFLkN

Upstream

Downstream

53

89

ATF-2 (human)
T71-p

ATF-2 (mouse)
T53-p

ATF-2 (rat)
T53-p

Effects on Modified Protein

activity, induced
enzymatic activity, induced
protein degradation
protein stabilization
ubiquitination

Effects on Biological Processes:

cell cycle regulation
cell growth, altered
cell motility, induced
signaling pathway regulation
transcription, altered
transcription, induced

Kinase, in vitro:

ERK1 (human)
ERK2 (human)
JNK1 (human)
JNK1 (mouse)
JNK2 (human)
P38A (human)
P38A (mouse)
P38B (human)
P38G (human)
PLK3 (human)

Putative in vivo kinases:

ERK1 (human)
ERK2 (human)
JNK1 (human)
JNK2 (human)
P38A (human)
P38B (human)

Regulatory protein:

Akt1 (human)
ATF7 iso5 (human)
CAMK4 (human)
DVL1 (human)
HBpX (retrovirus)
Ku70 (human)
Myc (human)
PRP4 (human)
RALA (human)
TMEM88 (human)

Treatment

ATF-2 (human)	IVADQtPtPtRFLkN	T71-p
ATF-2 (mouse)	IVADQtPtPtRFLKN	T53-p
ATF-2 (rat)	IVADQtPtPtRFLKN	T53-p

T73-p

ADQtPtPtRFLkNCE

Upstream

Downstream

4

17

Effects on Modified Protein

activity, induced
protein stabilization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

VRK1 (human)

Putative in vivo kinases:

VRK1 (human)

Regulatory protein:

CAMK4 (human)

ATF-2 (human)	ADQtPtPtRFLkNCE	T73-p
ATF-2 (mouse)	ADQtPtPtRFLKNCE	T55-p
ATF-2 (rat)	ADQtPtPtRFLKNCE	T55-p

K77-ub

PtPtRFLkNCEEVGL

0

1

ATF-2 (human)	PtPtRFLkNCEEVGL	K77-ub
ATF-2 (mouse)	PtPtRFLKNCEEVGL	K59
ATF-2 (rat)	PtPtRFLKNCEEVGL	K59

S90-p

GLFNELAsPFENEFk

Upstream

5

28

Kinase, in vitro:

JNK1 (human)
JNK2 (human)

Putative in vivo kinases:

JNK1 (human)

Treatment

anisomycin
ischemia
TNF

ATF-2 (human)	GLFNELAsPFENEFk	S90-p
ATF-2 (mouse)	GLFNELAsPFENEFK	S72-p
ATF-2 (rat)	GLFNELASPFENEFK	S72

K97-ac

sPFENEFkKASEDDI

0

1

ATF-2 (human)	sPFENEFkKASEDDI	K97-ac
ATF-2 (mouse)	sPFENEFKKASEDDI	K79
ATF-2 (rat)	SPFENEFKKASEDDI	K79

K97-ub

sPFENEFkKASEDDI

0

1

ATF-2 (human)	sPFENEFkKASEDDI	K97-ub
ATF-2 (mouse)	sPFENEFKKASEDDI	K79
ATF-2 (rat)	SPFENEFKKASEDDI	K79

K105-ac

KASEDDIkKMPLDLs

0

5

ATF-2 (human)	KASEDDIkKMPLDLs	K105-ac
ATF-2 (mouse)	KASEDDIKKMPLDLs	K87
ATF-2 (rat)	KASEDDIKKMPLDLs	K87

S112-p

kKMPLDLsPLAtPII

Upstream

0

85

Treatment

high_cell_density
ischemia
low_cell_density
LRRK2-IN-1
nocodazole
UV

ATF-2 (human)	kKMPLDLsPLAtPII	S112-p
ATF-2 (mouse)	KKMPLDLsPLAtPII	S94-p
ATF-2 (rat)	KKMPLDLsPLATPII	S94-p

T116-p

LDLsPLAtPIIRsKI

Upstream

1

40

Kinase, in vitro:

CDK2 (human)

Treatment

ischemia
nocodazole

ATF-2 (human)	LDLsPLAtPIIRsKI	T116-p
ATF-2 (mouse)	LDLsPLAtPIIRSKI	T98-p
ATF-2 (rat)	LDLsPLATPIIRSKI	T98

S121-p

LAtPIIRsKIEEPSV

Upstream

Downstream

1

0

Effects on Modified Protein

intracellular localization

Effects on Biological Processes:

transcription, induced

Kinase, in vitro:

PKCA (human)
PKCB (human)
PKCB iso2 (human)

Treatment

Go_6976
peptide_antagonist
phorbol_ester
retinoic_acid

ATF-2 (human)	LAtPIIRsKIEEPSV	S121-p
ATF-2 (mouse)	LAtPIIRSKIEEPSV	S103
ATF-2 (rat)	LATPIIRSKIEEPSV	S103

S136-p

VETTHQDsPLPHPES

0

8

ATF-2 (human)	VETTHQDsPLPHPES	S136-p
ATF-2 (mouse)	VETTHQDsPLPHPES	S118-p
ATF-2 (rat)	VETTHQDSPLPHPES	S118

S266

PGIPGPSSPQPVQSE

0

2

ATF-2 (human)	PGIPGPSSPQPVQSE	S266
ATF-2 (mouse)	PGIPGPSsPQPVQSE	S248-p
ATF-2 (rat)	PGIPGPSSPQPVQSE	S248

T283-p

MRLKAALtQQHPPVt

0

2

ATF-2 (human)	MRLKAALtQQHPPVt	T283-p
ATF-2 (mouse)	MRLKAALtQQHPPVt	T265-p
ATF-2 (rat)	MRLKAALTQQHPPVT	T265

T290-p

tQQHPPVtNGDTVKG

0

2

ATF-2 (human)	tQQHPPVtNGDTVKG	T290-p
ATF-2 (mouse)	tQQHPPVtNGDTVKG	T272-p
ATF-2 (rat)	TQQHPPVTNGDTVKG	T272

T290

tQQHPPVTNGDTVKG

0

2

ATF-2 (human)	tQQHPPVTNGDTVKG	T290
ATF-2 (mouse)	tQQHPPVtNGDTVKG	T272-gl
ATF-2 (rat)	TQQHPPVTNGDTVKG	T272

T305-p

HGSGLVRtQsEEsRP

0

5

ATF-2 (human)	HGSGLVRtQsEEsRP	T305-p
ATF-2 (mouse)	HGSGLVRtQsEEsRP	T287-p
ATF-2 (rat)	HGSGLVRAQSEESRP	A287

S307-p

SGLVRtQsEEsRPQS

0

9

ATF-2 (human)	SGLVRtQsEEsRPQS	S307-p
ATF-2 (mouse)	SGLVRtQsEEsRPQS	S289-p
ATF-2 (rat)	SGLVRAQSEESRPQS	S289

S310-p

VRtQsEEsRPQSLQQ

0

3

ATF-2 (human)	VRtQsEEsRPQSLQQ	S310-p
ATF-2 (mouse)	VRtQsEEsRPQSLQQ	S292-p
ATF-2 (rat)	VRAQSEESRPQSLQQ	S292

S321-p

SLQQPATsTTEtPAs

0

1

ATF-2 (human)	SLQQPATsTTEtPAs	S321-p
ATF-2 (mouse)	SLQQPATSTTETPAs	S303
ATF-2 (rat)	SLQQPATSTTETPAs	S303

T325-p

PATsTTEtPAsPAHT

0

1

ATF-2 (human)	PATsTTEtPAsPAHT	T325-p
ATF-2 (mouse)	PATSTTETPAsPAHt	T307
ATF-2 (rat)	PATSTTETPAsPAHT	T307

S328-p

sTTEtPAsPAHTtPQ

Upstream

0

28

Treatment

EGF

ATF-2 (human)	sTTEtPAsPAHTtPQ	S328-p
ATF-2 (mouse)	STTETPAsPAHtTPQ	S310-p
ATF-2 (rat)	STTETPAsPAHTTPQ	S310-p

T332

tPAsPAHTtPQtQST

0

2

ATF-2 (human)	tPAsPAHTtPQtQST	T332
ATF-2 (mouse)	TPAsPAHtTPQTQNT	T314-p
ATF-2 (rat)	TPAsPAHTTPQTQNT	T314

T333-p

PAsPAHTtPQtQSTs

0

2

ATF-2 (human)	PAsPAHTtPQtQSTs	T333-p
ATF-2 (mouse)	PAsPAHtTPQTQNTs	T315
ATF-2 (rat)	PAsPAHTTPQTQNTS	T315

T336-p

PAHTtPQtQSTsGRR

0

4

ATF-2 (human)	PAHTtPQtQSTsGRR	T336-p
ATF-2 (mouse)	PAHtTPQTQNTsGRR	T318
ATF-2 (rat)	PAHTTPQTQNTSGRR	T318

S340-p

tPQtQSTsGRRRRAA

Upstream

2

2

Kinase, in vitro:

PKCB (rat)

Treatment

peptide_antagonist
phorbol_ester
retinoic_acid

ATF-2 (human)	tPQtQSTsGRRRRAA	S340-p
ATF-2 (mouse)	TPQTQNTsGRRRRAA	S322-p
ATF-2 (rat)	TPQTQNTSGRRRRAA	S322

K357-ac

DPDEKRRkFLERNRA

Upstream

Downstream

2

1

Effects on Biological Processes:

cell growth, inhibited
cell motility, inhibited
transcription, altered
transcription, induced

Regulatory protein:

KRas (human)

ATF-2 (human)	DPDEKRRkFLERNRA	K357-ac
ATF-2 (mouse)	DPDEKRRKFLERNRA	K339
ATF-2 (rat)	DPDEKRRKFLERNRA	K339

S367-p

ERNRAAAsRCRQKRk

Upstream

2

0

Kinase, in vitro:

PKCB (rat)

Treatment

peptide_antagonist
phorbol_ester
retinoic_acid

ATF-2 (human)	ERNRAAAsRCRQKRk	S367-p
ATF-2 (mouse)	ERNRAAASRCRQKRK	S349
ATF-2 (rat)	ERNRAAASRCRQKRK	S349

K374-ac

sRCRQKRkVWVQSLE

Downstream

1

1

Effects on Biological Processes:

transcription, induced

ATF-2 (human)	sRCRQKRkVWVQSLE	K374-ac
ATF-2 (mouse)	SRCRQKRKVWVQSLE	K356
ATF-2 (rat)	SRCRQKRKVWVQSLE	K356

K409-ub

RNEVAQLkQLLLAHK

Upstream

0

5

Treatment

MG132

ATF-2 (human)	RNEVAQLkQLLLAHK	K409-ub
ATF-2 (mouse)	RNEVAQLkQLLLAHK	K391-ub
ATF-2 (rat)	RNEVAQLKQLLLAHK	K391

T431-p

QKKSGYHtADKDDSs

0

1

ATF-2 (human)	QKKSGYHtADKDDSs	T431-p
ATF-2 (mouse)	QKKSGYHTADKDDSS	T413
ATF-2 (rat)	QKKSGYHTADKDDSS	T413

S438-p

tADKDDSsEDIsVPS

0

1

ATF-2 (human)	tADKDDSsEDIsVPS	S438-p
ATF-2 (mouse)	TADKDDSSEDLSVPS	S420
ATF-2 (rat)	TADKDDSSEDLSVPS	S420

S442-p

DDSsEDIsVPSsPHt

0

1

ATF-2 (human)	DDSsEDIsVPSsPHt	S442-p
ATF-2 (mouse)	DDSSEDLSVPSSPHT	S424
ATF-2 (rat)	DDSSEDLSVPSSPHT	S424

S446-p

EDIsVPSsPHtEAIQ

0

2

ATF-2 (human)	EDIsVPSsPHtEAIQ	S446-p
ATF-2 (mouse)	EDLSVPSSPHTEAIQ	S428
ATF-2 (rat)	EDLSVPSSPHTEAIQ	S428

T449-p

sVPSsPHtEAIQHSS

0

1

ATF-2 (human)	sVPSsPHtEAIQHSS	T449-p
ATF-2 (mouse)	SVPSSPHTEAIQHSS	T431
ATF-2 (rat)	SVPSSPHTEAIQHSS	T431

S490-p

QSTEPALsQIVMAPS

Upstream

Downstream

1

0

Effects on Modified Protein

intracellular localization

Putative in vivo kinases:

ATM (human)

Treatment

ionizing_radiation
neocarzinostatin
UV

ATF-2 (human)	QSTEPALsQIVMAPS	S490-p
ATF-2 (mouse)	QSTEPALSQIVMAPP	S472
ATF-2 (rat)	QSTEPALSQIVMAPS	S472

S498-p

QIVMAPSsQSQPSGS

Upstream

Downstream

1

0

Effects on Modified Protein

intracellular localization

Putative in vivo kinases:

ATM (human)

Treatment

ionizing_radiation
neocarzinostatin
UV

ATF-2 (human)	QIVMAPSsQSQPSGS	S498-p
ATF-2 (mouse)	QIVMAPPSQAQPSGS	S480
ATF-2 (rat)	QIVMAPSSQAQPSGS	S480