Other Species / Isoforms
  PARP1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S364-p
FPPETsAsVAAtPPP
0 2
PARP1 (human) FPPETsAsVAAtPPP S364-p
PARP1 (mouse) gap -
PARP1 iso3 (mouse) gap -
PARP1 (rat) gap -
K674-m2
kPVQDLIkMIFDVEs
0 1
PARP1 (human) kPVQDLIkMIFDVEs K674-m2
PARP1 (mouse) gap -
PARP1 iso3 (mouse) gap -
PARP1 (rat) gap -
S5-p
___MAESsDkLYRVE
0 1
PARP1 (human) ___MAESsDkLYRVE S5-p
PARP1 (mouse) ___MAEASERLYRVQ S5
PARP1 iso3 (mouse) ___MAEASERLYRVE S5
PARP1 (rat) ___MAEATERLYRVE T5
K7-ub
_MAESsDkLYRVEYA
0 2
PARP1 (human) _MAESsDkLYRVEYA K7-ub
PARP1 (mouse) _MAEASERLYRVQYA R7
PARP1 iso3 (mouse) _MAEASERLYRVEYA R7
PARP1 (rat) _MAEATERLYRVEYA R7
K15-ub
LYRVEYAksGRASCK
0 1
PARP1 (human) LYRVEYAksGRASCK K15-ub
PARP1 (mouse) LYRVQYAKSGRASCK K15
PARP1 iso3 (mouse) LYRVEYAKsGRASCK K15
PARP1 (rat) LYRVEYAKSGRASCK K15
S16-p
YRVEYAksGRASCKK
0 1
PARP1 (human) YRVEYAksGRASCKK S16-p
PARP1 (mouse) YRVQYAKSGRASCKK S16
PARP1 iso3 (mouse) YRVEYAKsGRASCKK S16-p
PARP1 (rat) YRVEYAKSGRASCKK S16
S25-p
RASCKKCsEsIPKDs
0 1
PARP1 (human) RASCKKCsEsIPKDs S25-p
PARP1 (mouse) RASCKKCSESIPKDS S25
PARP1 iso3 (mouse) RASCKKCSESIPKDS S25
PARP1 (rat) RASCKKCSESIPKDS S25
S27-p
SCKKCsEsIPKDsLR
0 1
PARP1 (human) SCKKCsEsIPKDsLR S27-p
PARP1 (mouse) SCKKCSESIPKDSLR S27
PARP1 iso3 (mouse) SCKKCSESIPKDSLR S27
PARP1 (rat) SCKKCSESIPKDSLR S27
S32-p
sEsIPKDsLRMAIMV
0 1
PARP1 (human) sEsIPKDsLRMAIMV S32-p
PARP1 (mouse) SESIPKDSLRMAIMV S32
PARP1 iso3 (mouse) SESIPKDSLRMTIMV S32
PARP1 (rat) SESIPKDSLRMAIMV S32
S41-p
RMAIMVQsPMFDGKV
0 10
PARP1 (human) RMAIMVQsPMFDGKV S41-p
PARP1 (mouse) RMAIMVQSPMFDGKV S41
PARP1 iso3 (mouse) RMTIMVQSPMFDGKV S41
PARP1 (rat) RMAIMVQSPMFDGKV S41
R65-m1
WKVGHSIrHPDVEVD
0 1
PARP1 (human) WKVGHSIrHPDVEVD R65-m1
PARP1 (mouse) WKVGQSIRHPDVEVD R65
PARP1 iso3 (mouse) WKVGHSIRQPDVEVD R65
PARP1 (rat) WKVGHSIRQPDTEVD R65
S75-p
DVEVDGFsELrWDDQ
0 4
PARP1 (human) DVEVDGFsELrWDDQ S75-p
PARP1 (mouse) DVEVDGFSELRWDDQ S75
PARP1 iso3 (mouse) DVEVDGFsELRWDDQ S75-p
PARP1 (rat) DTEVDGFSELRWDDQ S75
R78-m1
VDGFsELrWDDQQkV
0 1
PARP1 (human) VDGFsELrWDDQQkV R78-m1
PARP1 (mouse) VDGFSELRWDDQQKV R78
PARP1 iso3 (mouse) VDGFsELRWDDQQKV R78
PARP1 (rat) VDGFSELRWDDQQKV R78
K84-ac
LrWDDQQkVKktAEA
0 1
PARP1 (human) LrWDDQQkVKktAEA K84-ac
PARP1 (mouse) LRWDDQQKVKKtAEA K84
PARP1 iso3 (mouse) LRWDDQQKVKKTAEA K84
PARP1 (rat) LRWDDQQKVKKTAEA K84
K84-ub
LrWDDQQkVKktAEA
0 1
PARP1 (human) LrWDDQQkVKktAEA K84-ub
PARP1 (mouse) LRWDDQQKVKKtAEA K84
PARP1 iso3 (mouse) LRWDDQQKVKKTAEA K84
PARP1 (rat) LRWDDQQKVKKTAEA K84
K87-ub
DDQQkVKktAEAGGV
0 2
PARP1 (human) DDQQkVKktAEAGGV K87-ub
PARP1 (mouse) DDQQKVKKtAEAGGV K87
PARP1 iso3 (mouse) DDQQKVKKTAEAGGV K87
PARP1 (rat) DDQQKVKKTAEAGGV K87
T88-p
DQQkVKktAEAGGVT
0 2
PARP1 (human) DQQkVKktAEAGGVT T88-p
PARP1 (mouse) DQQKVKKtAEAGGVA T88-p
PARP1 iso3 (mouse) DQQKVKKTAEAGGVA T88
PARP1 (rat) DQQKVKKTAEAGGVA T88
K97-ac
EAGGVTGkGQDGIGS
0 4
PARP1 (human) EAGGVTGkGQDGIGS K97-ac
PARP1 (mouse) EAGGVAGKGQDGSGG K97
PARP1 iso3 (mouse) EAGGVAGKGQDGSGG K97
PARP1 (rat) EAGGVAGKGQHGGGG K97
K97-ub
EAGGVTGkGQDGIGS
0 5
PARP1 (human) EAGGVTGkGQDGIGS K97-ub
PARP1 (mouse) EAGGVAGKGQDGSGG K97
PARP1 iso3 (mouse) EAGGVAGKGQDGSGG K97
PARP1 (rat) EAGGVAGKGQHGGGG K97
K97-sm
EAGGVTGkGQDGIGS
0 1
PARP1 (human) EAGGVTGkGQDGIGS K97-sm
PARP1 (mouse) EAGGVAGKGQDGSGG K97
PARP1 iso3 (mouse) EAGGVAGKGQDGSGG K97
PARP1 (rat) EAGGVAGKGQHGGGG K97
K105-ac
GQDGIGSkAEkTLGD
0 4
PARP1 (human) GQDGIGSkAEkTLGD K105-ac
PARP1 (mouse) GQDGSGGkAEKTLGD K105-ac
PARP1 iso3 (mouse) GQDGSGGKAEKTLGD K105
PARP1 (rat) GQHGGGGKAEKTLGD K105
K105-sm
GQDGIGSkAEkTLGD
0 1
PARP1 (human) GQDGIGSkAEkTLGD K105-sm
PARP1 (mouse) GQDGSGGKAEKTLGD K105
PARP1 iso3 (mouse) GQDGSGGKAEKTLGD K105
PARP1 (rat) GQHGGGGKAEKTLGD K105
K108-ac
GIGSkAEkTLGDFAA
0 2
PARP1 (human) GIGSkAEkTLGDFAA K108-ac
PARP1 (mouse) GSGGkAEKTLGDFAA K108
PARP1 iso3 (mouse) GSGGKAEKTLGDFLA K108
PARP1 (rat) GGGGKAEKTLGDFAA K108
K108-ub
GIGSkAEkTLGDFAA
0 2
PARP1 (human) GIGSkAEkTLGDFAA K108-ub
PARP1 (mouse) GSGGkAEKTLGDFAA K108
PARP1 iso3 (mouse) GSGGKAEKTLGDFLA K108
PARP1 (rat) GGGGKAEKTLGDFAA K108
Y117-p
LGDFAAEyAkSNRST
0 1
PARP1 (human) LGDFAAEyAkSNRST Y117-p
PARP1 (mouse) LGDFAAEYAKSNRSM Y117
PARP1 iso3 (mouse) LGDFLAEYAkSNRSM Y117
PARP1 (rat) LGDFAAEYAKSNRST Y117
K119-ub
DFAAEyAkSNRSTCK
0 12
PARP1 (human) DFAAEyAkSNRSTCK K119-ub
PARP1 (mouse) DFAAEYAKSNRSMCK K119
PARP1 iso3 (mouse) DFLAEYAkSNRSMCK K119-ub
PARP1 (rat) DFAAEYAKSNRSTCK K119
K131-ac
TCKGCMEkIEKGQVR
0 1
PARP1 (human) TCKGCMEkIEKGQVR K131-ac
PARP1 (mouse) MCKGCLEKIEKGQMR K131
PARP1 iso3 (mouse) MCKGCLEKIEKGQMR K131
PARP1 (rat) TCKGCMEKIEKGQMR K131
K131-ub
TCKGCMEkIEKGQVR
0 1
PARP1 (human) TCKGCMEkIEKGQVR K131-ub
PARP1 (mouse) MCKGCLEKIEKGQMR K131
PARP1 iso3 (mouse) MCKGCLEKIEKGQMR K131
PARP1 (rat) TCKGCMEKIEKGQMR K131
K148-ac
KKMVDPEkPQLGMID
0 2
PARP1 (human) KKMVDPEkPQLGMID K148-ac
PARP1 (mouse) KKMVDPEKPQLGMID K148
PARP1 iso3 (mouse) KKMVDPEKPQLGMID K148
PARP1 (rat) KKMLDPEKPQLGMID K148
K148-ub
KKMVDPEkPQLGMID
0 1
PARP1 (human) KKMVDPEkPQLGMID K148-ub
PARP1 (mouse) KKMVDPEKPQLGMID K148
PARP1 iso3 (mouse) KKMVDPEKPQLGMID K148
PARP1 (rat) KKMLDPEKPQLGMID K148
K148-sm
KKMVDPEkPQLGMID
0 1
PARP1 (human) KKMVDPEkPQLGMID K148-sm
PARP1 (mouse) KKMVDPEKPQLGMID K148
PARP1 iso3 (mouse) KKMVDPEKPQLGMID K148
PARP1 (rat) KKMLDPEKPQLGMID K148
R156-m1
PQLGMIDrWYHPGCF
0 1
PARP1 (human) PQLGMIDrWYHPGCF R156-m1
PARP1 (mouse) PQLGMIDRWYHPTCF R156
PARP1 iso3 (mouse) PQLGMIDRWYHPTCF R156
PARP1 (rat) PQLGMIDRWYHPTCF R156
K165-ub
YHPGCFVkNREELGF
0 5
PARP1 (human) YHPGCFVkNREELGF K165-ub
PARP1 (mouse) YHPTCFVKKRDELGF K165
PARP1 iso3 (mouse) YHPTCFVKKRDELGF K165
PARP1 (rat) YHPTCFVKNRDELGF K165
S177-p
LGFRPEYsAsQLkGF
Upstream
Downstream
2 4
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, induced
  • signaling pathway regulation
  • transcription, altered
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA2 (human)
Treatment
  • acadesine
  • compound_C
  • metformin
  • siRNA
PARP1 (human) LGFRPEYsAsQLkGF S177-p
PARP1 (mouse) LGFRPEYsASQLKGF S177-p
PARP1 iso3 (mouse) LGFRPEYSASQLKGF S177
PARP1 (rat) LGFRPEYSASQLKGF S177
S179-p
FRPEYsAsQLkGFsL
0 14
PARP1 (human) FRPEYsAsQLkGFsL S179-p
PARP1 (mouse) FRPEYsASQLKGFSL S179
PARP1 iso3 (mouse) FRPEYSASQLKGFSL S179
PARP1 (rat) FRPEYSASQLKGFSL S179
K182-ub
EYsAsQLkGFsLLAt
0 1
PARP1 (human) EYsAsQLkGFsLLAt K182-ub
PARP1 (mouse) EYsASQLKGFSLLSA K182
PARP1 iso3 (mouse) EYSASQLKGFSLLSA K182
PARP1 (rat) EYSASQLKGFSLLSA K182
S185-p
AsQLkGFsLLAtEDk
Upstream
0 6
Treatment
  • AZD1152
  • ZM447439
PARP1 (human) AsQLkGFsLLAtEDk S185-p
PARP1 (mouse) ASQLKGFSLLSAEDK S185
PARP1 iso3 (mouse) ASQLKGFSLLSAEDK S185
PARP1 (rat) ASQLKGFSLLSAEDK S185
T189-p
kGFsLLAtEDkEALK
0 1
PARP1 (human) kGFsLLAtEDkEALK T189-p
PARP1 (mouse) KGFSLLSAEDKEALK A189
PARP1 iso3 (mouse) KGFSLLSAEDKEALK A189
PARP1 (rat) KGFSLLSAEDKEALK A189
K192-ub
sLLAtEDkEALKkQL
0 1
PARP1 (human) sLLAtEDkEALKkQL K192-ub
PARP1 (mouse) SLLSAEDKEALKKQL K192
PARP1 iso3 (mouse) SLLSAEDKEALKKQL K192
PARP1 (rat) SLLSAEDKEALKKQL K192
K192-sm
sLLAtEDkEALKkQL
0 2
PARP1 (human) sLLAtEDkEALKkQL K192-sm
PARP1 (mouse) SLLSAEDKEALKKQL K192
PARP1 iso3 (mouse) SLLSAEDKEALKKQL K192
PARP1 (rat) SLLSAEDKEALKKQL K192
K197-ub
EDkEALKkQLPGVks
0 2
PARP1 (human) EDkEALKkQLPGVks K197-ub
PARP1 (mouse) EDKEALKKQLPAIKN K197
PARP1 iso3 (mouse) EDKEALKKQLPAIKN K197
PARP1 (rat) EDKEALKKQLPAVKS K197
K203-sm
KkQLPGVksEGKRkG
2 3
PARP1 (human) KkQLPGVksEGKRkG K203-sm
PARP1 (mouse) KKQLPAIKNEGKRKG K203
PARP1 iso3 (mouse) KKQLPAIKNEGKRKG K203
PARP1 (rat) KKQLPAVKSEGKRKC K203
S204-p
kQLPGVksEGKRkGD
0 2
PARP1 (human) kQLPGVksEGKRkGD S204-p
PARP1 (mouse) KQLPAIKNEGKRKGD N204
PARP1 iso3 (mouse) KQLPAIKNEGKRKGD N204
PARP1 (rat) KQLPAVKSEGKRKCD S204
K209-ub
VksEGKRkGDEVDGV
0 1
PARP1 (human) VksEGKRkGDEVDGV K209-ub
PARP1 (mouse) IKNEGKRKGDEVDGT K209
PARP1 iso3 (mouse) IKNEGKRKGDEVDGT K209
PARP1 (rat) VKSEGKRKCDEVDGI K209
K221-ub
DGVDEVAkKKsKKEK
0 1
PARP1 (human) DGVDEVAkKKsKKEK K221-ub
PARP1 (mouse) DGTDEVAKKKSRKET K221
PARP1 iso3 (mouse) DGTDEVAKKKSKKGK K221
PARP1 (rat) DGIDEVAKKKSKKGK K221
S224-p
DEVAkKKsKKEKDkD
0 1
PARP1 (human) DEVAkKKsKKEKDkD S224-p
PARP1 (mouse) DEVAKKKSRKETDKY S224
PARP1 iso3 (mouse) DEVAKKKSKKGKDKD S224
PARP1 (rat) DEVAKKKSKKGKDKE S224
K230-ac
KsKKEKDkDSKLEKA
0 1
PARP1 (human) KsKKEKDkDSKLEKA K230-ac
PARP1 (mouse) KSRKETDKYSKLEKA K230
PARP1 iso3 (mouse) KSKKGKDKDSSKLEK K230
PARP1 (rat) KSKKGKDKESSKLEK K230
K239-ub
SKLEKALkAQNDLIW
0 2
PARP1 (human) SKLEKALkAQNDLIW K239-ub
PARP1 (mouse) SKLEKALKAQNELIW K239
PARP1 iso3 (mouse) SKLEKALKAQNELIW K240
PARP1 (rat) SKLEKALKAQNELVW K240
K249-ac
NDLIWNIkDELkkVC
0 3
PARP1 (human) NDLIWNIkDELkkVC K249-ac
PARP1 (mouse) NELIWNIKDELKKAC K249
PARP1 iso3 (mouse) NELIWNIKDELKKAC K250
PARP1 (rat) NELVWNIKDELKKAC K250
K249-ub
NDLIWNIkDELkkVC
0 4
PARP1 (human) NDLIWNIkDELkkVC K249-ub
PARP1 (mouse) NELIWNIKDELKKAC K249
PARP1 iso3 (mouse) NELIWNIKDELKKAC K250
PARP1 (rat) NELVWNIKDELKKAC K250
K249-sm
NDLIWNIkDELkkVC
0 2
PARP1 (human) NDLIWNIkDELkkVC K249-sm
PARP1 (mouse) NELIWNIKDELKKAC K249
PARP1 iso3 (mouse) NELIWNIKDELKKAC K250
PARP1 (rat) NELVWNIKDELKKAC K250
K253-ac
WNIkDELkkVCsTND
0 7
PARP1 (human) WNIkDELkkVCsTND K253-ac
PARP1 (mouse) WNIKDELKKACSTND K253
PARP1 iso3 (mouse) WNIKDELKKACSTND K254
PARP1 (rat) WNIKDELKKACSTND K254
K254-ac
NIkDELkkVCsTNDL
0 1
PARP1 (human) NIkDELkkVCsTNDL K254-ac
PARP1 (mouse) NIKDELKKACSTNDL K254
PARP1 iso3 (mouse) NIKDELKKACSTNDL K255
PARP1 (rat) NIKDELKKACSTNDL K255
K254-ub
NIkDELkkVCsTNDL
0 3
PARP1 (human) NIkDELkkVCsTNDL K254-ub
PARP1 (mouse) NIKDELKKACSTNDL K254
PARP1 iso3 (mouse) NIKDELKKACSTNDL K255
PARP1 (rat) NIKDELKKACSTNDL K255
S257-p
DELkkVCsTNDLkEL
0 4
PARP1 (human) DELkkVCsTNDLkEL S257-p
PARP1 (mouse) DELKKACSTNDLKEL S257
PARP1 iso3 (mouse) DELKKACSTNDLKEL S258
PARP1 (rat) DELKKACSTNDLKEL S258
K262-ac
VCsTNDLkELLIFNk
Upstream
0 1
Treatment
  • vorinostat
PARP1 (human) VCsTNDLkELLIFNk K262-ac
PARP1 (mouse) ACSTNDLKELLIFNQ K262
PARP1 iso3 (mouse) ACSTNDLKELLIFNQ K263
PARP1 (rat) ACSTNDLKELLIFNQ K263
K262-ub
VCsTNDLkELLIFNk
0 5
PARP1 (human) VCsTNDLkELLIFNk K262-ub
PARP1 (mouse) ACSTNDLKELLIFNQ K262
PARP1 iso3 (mouse) ACSTNDLKELLIFNQ K263
PARP1 (rat) ACSTNDLKELLIFNQ K263
K262-sm
VCsTNDLkELLIFNk
0 2
PARP1 (human) VCsTNDLkELLIFNk K262-sm
PARP1 (mouse) ACSTNDLKELLIFNQ K262
PARP1 iso3 (mouse) ACSTNDLKELLIFNQ K263
PARP1 (rat) ACSTNDLKELLIFNQ K263
K269-ub
kELLIFNkQQVPsGE
0 41
PARP1 (human) kELLIFNkQQVPsGE K269-ub
PARP1 (mouse) KELLIFNQQQVPSGE Q269
PARP1 iso3 (mouse) KELLIFNQQQVPSGE Q270
PARP1 (rat) KELLIFNQQQVPSGE Q270
S274-p
FNkQQVPsGEsAILD
0 5
PARP1 (human) FNkQQVPsGEsAILD S274-p
PARP1 (mouse) FNQQQVPSGESAILD S274
PARP1 iso3 (mouse) FNQQQVPSGESAILD S275
PARP1 (rat) FNQQQVPSGESAILD S275
S277-p
QQVPsGEsAILDrVA
0 4
PARP1 (human) QQVPsGEsAILDrVA S277-p
PARP1 (mouse) QQVPSGESAILDRVA S277
PARP1 iso3 (mouse) QQVPSGESAILDRVA S278
PARP1 (rat) QQVPSGESAILDRVA S278
R282-m1
GEsAILDrVADGMVF
0 1
PARP1 (human) GEsAILDrVADGMVF R282-m1
PARP1 (mouse) GESAILDRVADGMAF R282
PARP1 iso3 (mouse) GESAILDRVADGMAF R283
PARP1 (rat) GESAILDRVADGMAF R283
E296
FGALLPCEECSGQLV
0 1
PARP1 (human) FGALLPCEECSGQLV E296
PARP1 (mouse) FGALLPCkECSGQLV K296-ub
PARP1 iso3 (mouse) FGALLPCKECSGQLV K297
PARP1 (rat) FGALLPCKECSGQLV K297
K320-ub
GDVTAWTkCMVKTQT
0 2
PARP1 (human) GDVTAWTkCMVKTQT K320-ub
PARP1 (mouse) GDVTAWTKCMVKTQN K320
PARP1 iso3 (mouse) GDVTAWTKCMVKTQN K321
PARP1 (rat) GDVTAWTKCMVKTQN K321
K331-ub
KTQTPNRkEWVTPkE
0 4
PARP1 (human) KTQTPNRkEWVTPkE K331-ub
PARP1 (mouse) KTQNPSRKEWVTPKE K331
PARP1 iso3 (mouse) KTQNPSRKEWVTPKG K332
PARP1 (rat) KTQNPSRKEWVTPKE K332
K331-sm
KTQTPNRkEWVTPkE
0 1
PARP1 (human) KTQTPNRkEWVTPkE K331-sm
PARP1 (mouse) KTQNPSRKEWVTPKE K331
PARP1 iso3 (mouse) KTQNPSRKEWVTPKG K332
PARP1 (rat) KTQNPSRKEWVTPKE K332
K337-ub
RkEWVTPkEFREIsY
0 5
PARP1 (human) RkEWVTPkEFREIsY K337-ub
PARP1 (mouse) RKEWVTPKEFREISY K337
PARP1 iso3 (mouse) RKEWVTPKGFREISY K338
PARP1 (rat) RKEWVTPKEFREISY K338
K337-sm
RkEWVTPkEFREIsY
0 2
PARP1 (human) RkEWVTPkEFREIsY K337-sm
PARP1 (mouse) RKEWVTPKEFREISY K337
PARP1 iso3 (mouse) RKEWVTPKGFREISY K338
PARP1 (rat) RKEWVTPKEFREISY K338
S343-p
PkEFREIsYLKKLKV
0 1
PARP1 (human) PkEFREIsYLKKLKV S343-p
PARP1 (mouse) PKEFREISYLKKLKV S343
PARP1 iso3 (mouse) PKGFREISYLKKLKV S344
PARP1 (rat) PKEFREISYLKKLKI S344
S362-p
RIFPPETsAsVAAtP
0 1
PARP1 (human) RIFPPETsAsVAAtP S362-p
PARP1 (mouse) RIFPPESSAPITVHW S362
PARP1 iso3 (mouse) RIFPPESSAPAPLAL S363
PARP1 (rat) RLFPPESSAPAPPAP S363
T368-p
TsAsVAAtPPPstAs
0 9
PARP1 (human) TsAsVAAtPPPstAs T368-p
PARP1 (mouse) SSAPITVHWPLSVTS H368
PARP1 iso3 (mouse) SSAPAPLALPLSVTS A369
PARP1 (rat) SSAPAPPAPPVSITS A369
S372-p
VAAtPPPstAsAPAA
Upstream
Downstream
2 2
Effects on Modified Protein
  • enzymatic activity, induced
Putative in vivo kinases:
  • ERK2 (human)
Treatment
  • PD98059
PARP1 (human) VAAtPPPstAsAPAA S372-p
PARP1 (mouse) ITVHWPLSVTSAPTA S372
PARP1 iso3 (mouse) APLALPLSVTSAPTA S373
PARP1 (rat) APPAPPVSITSAPTA S373
T373-p
AAtPPPstAsAPAAV
Upstream
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, induced
Putative in vivo kinases:
  • ERK2 (human)
Treatment
  • PD98059
PARP1 (human) AAtPPPstAsAPAAV T373-p
PARP1 (mouse) VHWPLSVTSAPTAVN T374
PARP1 iso3 (mouse) LALPLSVTSAPTAVN T375
PARP1 (rat) PAPPVSITSAPTAVN T375
S375-p
tPPPstAsAPAAVNS
0 1
PARP1 (human) tPPPstAsAPAAVNS S375-p
PARP1 (mouse) HWPLSVTSAPTAVNS S375
PARP1 iso3 (mouse) ALPLSVTSAPTAVNS S376
PARP1 (rat) APPVSITSAPTAVNS S376
S391-p
ASADKPLsNMkILTL
0 1
PARP1 (human) ASADKPLsNMkILTL S391-p
PARP1 (mouse) APADKPLSNMKILTL S391
PARP1 iso3 (mouse) APADKPLSNMKILTL S392
PARP1 (rat) APADKPLSNMKILTL S392
K394-ub
DKPLsNMkILTLGkL
Upstream
0 2
Treatment
  • MG132
PARP1 (human) DKPLsNMkILTLGkL K394-ub
PARP1 (mouse) DKPLSNMKILTLGKL K394
PARP1 iso3 (mouse) DKPLSNMKILTLGKL K395
PARP1 (rat) DKPLSNMKILTLGKL K395
K400-ac
MkILTLGkLSRNKDE
0 6
PARP1 (human) MkILTLGkLSRNKDE K400-ac
PARP1 (mouse) MKILTLGKLSQNKDE K400
PARP1 iso3 (mouse) MKILTLGKLSQNKDE K401
PARP1 (rat) MKILTLGKLSQNKDE K401
K400-ub
MkILTLGkLSRNKDE
Upstream
0 10
Treatment
  • MG132
PARP1 (human) MkILTLGkLSRNKDE K400-ub
PARP1 (mouse) MKILTLGKLSQNKDE K400
PARP1 iso3 (mouse) MKILTLGKLSQNKDE K401
PARP1 (rat) MKILTLGKLSQNKDE K401
K409-sm
SRNKDEVkAMIEkLG
0 2
PARP1 (human) SRNKDEVkAMIEkLG K409-sm
PARP1 (mouse) SQNKDEAKAVIEKLG K409
PARP1 iso3 (mouse) SQNKDEAKAVIEKLG K410
PARP1 (rat) SQNKDEAKAMIEKLG K410
K414-ub
EVkAMIEkLGGkLtG
0 5
PARP1 (human) EVkAMIEkLGGkLtG K414-ub
PARP1 (mouse) EAKAVIEKLGGKLTG K414
PARP1 iso3 (mouse) EAKAVIEKLGGKLTG K415
PARP1 (rat) EAKAMIEKLGGKLTG K415
K418-ac
MIEkLGGkLtGTANk
0 4
PARP1 (human) MIEkLGGkLtGTANk K418-ac
PARP1 (mouse) VIEKLGGKLTGSANK K418
PARP1 iso3 (mouse) VIEKLGGKLTGSANK K419
PARP1 (rat) MIEKLGGKLTGSANK K419
K418-ub
MIEkLGGkLtGTANk
0 2
PARP1 (human) MIEkLGGkLtGTANk K418-ub
PARP1 (mouse) VIEKLGGKLTGSANK K418
PARP1 iso3 (mouse) VIEKLGGKLTGSANK K419
PARP1 (rat) MIEKLGGKLTGSANK K419
T420-p
EkLGGkLtGTANkAS
0 4
PARP1 (human) EkLGGkLtGTANkAS T420-p
PARP1 (mouse) EKLGGKLTGSANKAS T420
PARP1 iso3 (mouse) EKLGGKLTGSANKAS T421
PARP1 (rat) EKLGGKLTGSANKAS T421
K425-ub
kLtGTANkASLCIST
0 4
PARP1 (human) kLtGTANkASLCIST K425-ub
PARP1 (mouse) KLTGSANKASLCISI K425
PARP1 iso3 (mouse) KLTGSANKASLCIST K426
PARP1 (rat) KLTGSANKASLCIST K426
K433-ac
ASLCISTkkEVEKMN
0 3
PARP1 (human) ASLCISTkkEVEKMN K433-ac
PARP1 (mouse) ASLCISIKKEVEKMN K433
PARP1 iso3 (mouse) ASLCISTKKEVEKMS K434
PARP1 (rat) ASLCISTKKEVEKMS K434
K433-sm
ASLCISTkkEVEKMN
0 1
PARP1 (human) ASLCISTkkEVEKMN K433-sm
PARP1 (mouse) ASLCISIKKEVEKMN K433
PARP1 iso3 (mouse) ASLCISTKKEVEKMS K434
PARP1 (rat) ASLCISTKKEVEKMS K434
K434-ub
SLCISTkkEVEKMNK
0 1
PARP1 (human) SLCISTkkEVEKMNK K434-ub
PARP1 (mouse) SLCISIKKEVEKMNK K434
PARP1 iso3 (mouse) SLCISTKKEVEKMSk K435
PARP1 (rat) SLCISTKKEVEKMSK K435
K441
kEVEKMNKKMEEVkE
0 1
PARP1 (human) kEVEKMNKKMEEVkE K441
PARP1 (mouse) KEVEKMNKKMEEVKE K441
PARP1 iso3 (mouse) KEVEKMSkkMEEVKA K442-sc
PARP1 (rat) KEVEKMSKKMEEVKA K442
K442
EVEKMNKKMEEVkEA
0 1
PARP1 (human) EVEKMNKKMEEVkEA K442
PARP1 (mouse) EVEKMNKKMEEVKEA K442
PARP1 iso3 (mouse) EVEKMSkkMEEVKAA K443-sc
PARP1 (rat) EVEKMSKKMEEVKAA K443
K447-ub
NKKMEEVkEANIRVV
0 8
PARP1 (human) NKKMEEVkEANIRVV K447-ub
PARP1 (mouse) NKKMEEVKEANIRVV K447
PARP1 iso3 (mouse) SkkMEEVKAANVRVV K448
PARP1 (rat) SKKMEEVKAANVRVV K448
S455-p
EANIRVVsEDFLQDV
0 1
PARP1 (human) EANIRVVsEDFLQDV S455-p
PARP1 (mouse) EANIRVVSEDFLQDV S455
PARP1 iso3 (mouse) AANVRVVCEDFLQDV C456
PARP1 (rat) AANVRVVCEDFLQDV C456
S465-p
FLQDVSAsTkSLQEL
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
Treatment
  • cAMP_analog
  • H2O2
  • PKI-(14-22)amide
  • propranolol
PARP1 (human) FLQDVSAsTkSLQEL S465-p
PARP1 (mouse) FLQDVSASTKSLQDL S465
PARP1 iso3 (mouse) FLQDVSASTkSLQEL S466
PARP1 (rat) FLQDVSASAKSLQEL S466
K467
QDVSAsTKSLQELFL
0 3
PARP1 (human) QDVSAsTKSLQELFL K467
PARP1 (mouse) QDVSASTKSLQDLLS K467
PARP1 iso3 (mouse) QDVSASTkSLQELLS K468-ub
PARP1 (rat) QDVSASAKSLQELLS K468
K467-sm
QDVSAsTkSLQELFL
0 2
PARP1 (human) QDVSAsTkSLQELFL K467-sm
PARP1 (mouse) QDVSASTKSLQDLLS K467
PARP1 iso3 (mouse) QDVSASTKSLQELLS K468
PARP1 (rat) QDVSASAKSLQELLS K468
S479-p
LFLAHILsPWGAEVk
0 1
PARP1 (human) LFLAHILsPWGAEVk S479-p
PARP1 (mouse) LLSAHSLSPWGAEVK S479
PARP1 iso3 (mouse) LLSAHSLSSWGAEVK S480
PARP1 (rat) LLSAHSLSSWGAEVK S480
K486-ub
sPWGAEVkAEPVEVV
0 1
PARP1 (human) sPWGAEVkAEPVEVV K486-ub
PARP1 (mouse) SPWGAEVKAEPGEVV K486
PARP1 iso3 (mouse) SSWGAEVKAEPGEVV K487
PARP1 (rat) SSWGAEVKVEPGEVV K487
K486-sm
sPWGAEVkAEPVEVV
3 5
PARP1 (human) sPWGAEVkAEPVEVV K486-sm
PARP1 (mouse) SPWGAEVKAEPGEVV K486
PARP1 iso3 (mouse) SSWGAEVKAEPGEVV K487
PARP1 (rat) SSWGAEVKVEPGEVV K487
K498-ac
EVVAPRGksGAALsk
1 0
PARP1 (human) EVVAPRGksGAALsk K498-ac
PARP1 (mouse) EVVAPRGKSAAPSKK K498
PARP1 iso3 (mouse) EVVAPKGKSAAPSKK K499
PARP1 (rat) EVVVPKGKSAAPSKK K499
S499-p
VVAPRGksGAALskK
0 2
PARP1 (human) VVAPRGksGAALskK S499-p
PARP1 (mouse) VVAPRGKSAAPSKKS S499
PARP1 iso3 (mouse) VVAPKGKSAAPSKKS S500
PARP1 (rat) VVVPKGKSAAPSKKS S500
S504-p
GksGAALskKSkGQV
0 1
PARP1 (human) GksGAALskKSkGQV S504-p
PARP1 (mouse) RGKSAAPSKKSKGCF S503
PARP1 iso3 (mouse) KGKSAAPSKKSKGAV S504
PARP1 (rat) KGKSAAPSKKSKGAV S504
K505-ac
ksGAALskKSkGQVk
1 0
PARP1 (human) ksGAALskKSkGQVk K505-ac
PARP1 (mouse) GKSAAPSKKSKGCFK K504
PARP1 iso3 (mouse) GKSAAPSKKSKGAVK K505
PARP1 (rat) GKSAAPSKKSKGAVK K505
K508-ac
AALskKSkGQVkEEG
1 0
PARP1 (human) AALskKSkGQVkEEG K508-ac
PARP1 (mouse) AAPSKKSKGCFKEEG K507
PARP1 iso3 (mouse) AAPSKKSKGAVKEEG K508
PARP1 (rat) AAPSKKSKGAVKEEG K508
K508-m1
AALskKSkGQVkEEG
1 8
PARP1 (human) AALskKSkGQVkEEG K508-m1
PARP1 (mouse) AAPSKKSKGCFKEEG K507
PARP1 iso3 (mouse) AAPSKKSKGAVKEEG K508
PARP1 (rat) AAPSKKSKGAVKEEG K508
K512-sm
kKSkGQVkEEGINks
0 3
PARP1 (human) kKSkGQVkEEGINks K512-sm
PARP1 (mouse) KKSKGCFKEEGVNKS K511
PARP1 iso3 (mouse) KKSKGAVKEEGVNKS K512
PARP1 (rat) KKSKGAVKEEGVNKS K512
K518-ac
VkEEGINksEkRMkL
0 3
PARP1 (human) VkEEGINksEkRMkL K518-ac