Other Species / Isoforms
  NHE3 (rabbit)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y395
QTWLLNRYRMVQLEL
0 1
NHE3 (human) QTWLLNRyRMVQLEP Y396-p
NHE3 (mouse) QTWILNRYRMVQLET Y391
NHE3 (rat) QTWILNRYRMVQLET Y393
NHE3 (rabbit) QTWLLNRYRMVQLEL Y395
Y501
SGQIGHNYLRDKWAN
0 2
NHE3 (human) SGQIGHNyLRDKWSH Y502-p
NHE3 (mouse) SGQIGHNYLRDKWSN Y497
NHE3 (rat) SGQIGHNYLRDKWSN Y499
NHE3 (rabbit) SGQIGHNYLRDKWAN Y501
S515-p
NFDRRFLsKLLMRQs
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • Akt_inhibitor_VIII
NHE3 (human) HFDRKFLSRVLMRRS S516
NHE3 (mouse) NFDRKFLSkVLMRRS S511
NHE3 (rat) NFDRKFLSKVLMRRS S513
NHE3 (rabbit) NFDRRFLsKLLMRQs S515-p
K516
FDRRFLsKLLMRQsA
0 1
NHE3 (human) FDRKFLSRVLMRRSA R517
NHE3 (mouse) FDRKFLSkVLMRRSA K512-ub
NHE3 (rat) FDRKFLSKVLMRRSA K514
NHE3 (rabbit) FDRRFLsKLLMRQsA K516
S522-p
sKLLMRQsAQKsRDR
1 0
NHE3 (human) SRVLMRRSAQKSRDR S523
NHE3 (mouse) SkVLMRRSAQKSRDR S518
NHE3 (rat) SKVLMRRSAQKSRDR S520
NHE3 (rabbit) sKLLMRQsAQKsRDR S522-p
S526-p
MRQsAQKsRDRILNV
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • SB216763
NHE3 (human) MRRSAQKSRDRILNV S527
NHE3 (mouse) MRRSAQKSRDRILNV S522
NHE3 (rat) MRRSAQKSRDRILNV S524
NHE3 (rabbit) MRQsAQKsRDRILNV S526-p
S544
LNLKDAISYVTEGER
0 1
NHE3 (human) LNLKDAIsYVAEGER S545-p
NHE3 (mouse) LNLKDAISYVAEGER S540
NHE3 (rat) LNLKDAISYVAEGER S542
NHE3 (rabbit) LNLKDAISYVTEGER S544
S554-p
TEGERRGsLAFIRSP
Upstream
Downstream
27 9
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
Kinase, in vitro:
  • PKG2 (human)
Putative in vivo kinases:
  • CK2A1 (human)
  • PKG2 (human)
Treatment
  • 8pCPT-cGMP
  • cAMP_analog
  • cGMP_analog
  • H-89
  • NKH_477
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NHE3 (human) AEGERRGsLAFIRSP S555-p
NHE3 (mouse) AEGERRGsLAFIRSP S550-p
NHE3 (rat) AEGERRGsLAFIRSP S552-p
NHE3 (rabbit) TEGERRGsLAFIRSP S554-p
S562
LAFIRSPSTDNMVNV
1 5
NHE3 (human) LAFIRSPstDNVVNV S563-p
NHE3 (mouse) LAFIRSPSTDNMVNV S558
NHE3 (rat) LAFIRSPsTDNMVNV S560-p
NHE3 (rabbit) LAFIRSPSTDNMVNV S562
T563
AFIRSPSTDNMVNVD
0 1
NHE3 (human) AFIRSPstDNVVNVD T564-p
NHE3 (mouse) AFIRSPSTDNMVNVD T559
NHE3 (rat) AFIRSPsTDNMVNVD T561
NHE3 (rabbit) AFIRSPSTDNMVNVD T563
S592
YLLRESASAVCLDMQ
0 2
NHE3 (human) YLLRENVsAVCLDMQ S592-p
NHE3 (mouse) YFLRENVsAVCLDMQ S588-p
NHE3 (rat) YFLRENVSAVCLDMQ S590
NHE3 (rabbit) YLLRESASAVCLDMQ S592
S600
AVCLDMQSLEQRRRs
0 1
NHE3 (human) AVCLDMQsLEQRRRS S600-p
NHE3 (mouse) AVCLDMQSLEQRRRs S596
NHE3 (rat) AVCLDMQSLEQRRRs S598
NHE3 (rabbit) AVCLDMQSLEQRRRs S600
S607-p
SLEQRRRsVRDAEDV
Upstream
Downstream
13 1
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
Kinase, in vitro:
  • PKG2 (human)
Putative in vivo kinases:
  • PKG2 (human)
Treatment
  • cGMP_analog
  • NKH_477
NHE3 (human) sLEQRRRSIRDAEDM S607
NHE3 (mouse) SLEQRRRsIRDTEDM S603-p
NHE3 (rat) SLEQRRRsIRDTEDM S605-p
NHE3 (rabbit) SLEQRRRsVRDAEDV S607-p
S641
LYSRHVLSPSEDEKQ
0 2
NHE3 (human) LYSRHELtPTEDEKQ T641-p
NHE3 (mouse) LYSRHELTPNEDEKQ T637
NHE3 (rat) LYSRHELtPNEDEKQ T639-p
NHE3 (rabbit) LYSRHVLSPSEDEKQ S641
S663-p
TMRKRLEsFKSAKLG
Upstream
Downstream
4 3
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • intracellular localization
Kinase, in vitro:
  • SGK1 (human)
Putative in vivo kinases:
  • PKG2 (human)
Treatment
  • cGMP_analog
  • dexamethasone
NHE3 (human) TMRKRLEsFKSTKLG S663-p
NHE3 (mouse) TMRKRLESFKSAKLG S659
NHE3 (rat) TMRKRLEsFKSAKLG S661-p
NHE3 (rabbit) TMRKRLEsFKSAKLG S663-p
R682
KKATKHKRERERAQK
0 1
NHE3 (human) KKAAKLYkRERAQKR K682-ac
NHE3 (mouse) KKAAKLYKRERAQKR K678
NHE3 (rat) KKAAKLYKRERAQKR K680
NHE3 (rabbit) KKATKHKRERERAQK R682
S719-p
KERELELsDPEEAPD
Upstream
Downstream
3 3
Effects on Modified Protein
  • activity, induced
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • CK2A1 (human)
  • CK2B (human)
Putative in vivo kinases:
  • CK2A1 (human)
Treatment
  • DMAT
  • TBB
NHE3 (human) KEKDLELSDTEEPPN S718
NHE3 (mouse) KEKDLELSEHEEATN S714
NHE3 (rat) KEKDLELsEPEEATN S716-p
NHE3 (rabbit) KERELELsDPEEAPD S719-p
S797
ARVQIPYSPGNFRRL
0 4
NHE3 (human) ARTQIPYsPGTFCRL S794-p
NHE3 (mouse) ARVQIPNsPsNFRRL S789-p
NHE3 (rat) ARVQIPNsPsNFRRL S791-p
NHE3 (rabbit) ARVQIPYSPGNFRRL S797
G799
VQIPYSPGNFRRLAP
0 2
NHE3 (human) TQIPYsPGTFCRLMP G796
NHE3 (mouse) VQIPNsPsNFRRLTP S791-p
NHE3 (rat) VQIPNsPsNFRRLTP S793-p
NHE3 (rabbit) VQIPYSPGNFRRLAP G799
S810
RLAPFRLSNKSVDSF
0 2
NHE3 (human) RLMPFRLSSKSVDSF S807
NHE3 (mouse) RLTPFRLsNKsVDsF S802-p
NHE3 (rat) RLTPFRLsNksVDsF S804-p
NHE3 (rabbit) RLAPFRLSNKSVDSF S810
K812
APFRLSNKSVDSFLL
0 1
NHE3 (human) MPFRLSSKSVDSFLQ K809
NHE3 (mouse) TPFRLsNKsVDsFLQ K804
NHE3 (rat) TPFRLsNksVDsFLQ K806-ac
NHE3 (rabbit) APFRLSNKSVDSFLL K812
S813
PFRLSNKSVDSFLLA
0 2
NHE3 (human) PFRLSSKSVDSFLQA S810
NHE3 (mouse) PFRLsNKsVDsFLQA S805-p
NHE3 (rat) PFRLsNksVDsFLQA S807-p
NHE3 (rabbit) PFRLSNKSVDSFLLA S813
S816
LSNKSVDSFLLAEDG
0 2
NHE3 (human) LSSKSVDSFLQADGP S813
NHE3 (mouse) LsNKsVDsFLQADGH S808-p
NHE3 (rat) LsNksVDsFLQADGP S810-p
NHE3 (rabbit) LSNKSVDSFLLAEDG S816
-
gap
0 1
NHE3 (human) EERPPAALPESTHM_ L828
NHE3 (mouse) EEQLQPAAPESTHM_ A823
NHE3 (rat) EEQLQPAsPESTHM_ S825-p
NHE3 (rabbit) gap -