|
T37-p
|
VKMKEALttDRGKTL
|
|
|
0
|
1
|
|
|
PKCD (human)
|
VKMKEALSTERGKtL
|
S37
|
|
PKCD iso2 (human)
|
VKMKEALSTERGKTL
|
S37
|
|
PKCD (mouse)
|
VKMKEALSTERGKtL
|
S37
|
|
PKCD iso2 (mouse)
|
VKMKEALSTERGKTL
|
S37
|
|
PKCD (rat)
|
VKMKEALttDRGKTL
|
T37-p
|
|
|
T38-p
|
KMKEALttDRGKTLV
|
|
|
0
|
1
|
|
|
PKCD (human)
|
KMKEALSTERGKtLV
|
T38
|
|
PKCD iso2 (human)
|
KMKEALSTERGKTLV
|
T38
|
|
PKCD (mouse)
|
KMKEALSTERGKtLV
|
T38
|
|
PKCD iso2 (mouse)
|
KMKEALSTERGKTLV
|
T38
|
|
PKCD (rat)
|
KMKEALttDRGKTLV
|
T38-p
|
|
|
T43
|
LttDRGKTLVQKKPt
|
|
|
0
|
7
|
|
|
PKCD (human)
|
LSTERGKtLVQKKPt
|
T43-p
|
|
PKCD iso2 (human)
|
LSTERGKTLVQKKPT
|
T43
|
|
PKCD (mouse)
|
LSTERGKtLVQkKPT
|
T43-p
|
|
PKCD iso2 (mouse)
|
LSTERGKTLVQKKPT
|
T43
|
|
PKCD (rat)
|
LttDRGKTLVQKKPt
|
T43
|
|
|
K47
|
RGKTLVQKKPtMYPE
|
|
|
0
|
1
|
|
|
PKCD (human)
|
RGKtLVQKKPtMyPE
|
K47
|
|
PKCD iso2 (human)
|
RGKTLVQKKPTMYPE
|
K47
|
|
PKCD (mouse)
|
RGKtLVQkKPTMyPE
|
K47-ac
|
|
PKCD iso2 (mouse)
|
RGKTLVQKKPTMYPE
|
K47
|
|
PKCD (rat)
|
RGKTLVQKKPtMYPE
|
K47
|
|
|
T50-p
|
TLVQKKPtMYPEWKS
|
|
|
0
|
4
|
|
|
PKCD (human)
|
tLVQKKPtMyPEWKS
|
T50-p
|
|
PKCD iso2 (human)
|
TLVQKKPTMYPEWKS
|
T50
|
|
PKCD (mouse)
|
tLVQkKPTMyPEWKT
|
T50
|
|
PKCD iso2 (mouse)
|
TLVQKKPTMYPEWKT
|
T50
|
|
PKCD (rat)
|
TLVQKKPtMYPEWKS
|
T50-p
|
|
|
Y52
|
VQKKPtMYPEWKSTF
|
|
|
4
|
0
|
|
|
PKCD (human)
|
VQKKPtMyPEWKSTF
|
Y52-p
|
|
PKCD iso2 (human)
|
VQKKPTMYPEWKSTF
|
Y52
|
|
PKCD (mouse)
|
VQkKPTMyPEWKTTF
|
Y52-p
|
|
PKCD iso2 (mouse)
|
VQKKPTMYPEWKTTF
|
Y52
|
|
PKCD (rat)
|
VQKKPtMYPEWKSTF
|
Y52
|
|
|
Y64-p
|
STFDAHIyEGRVIQI
|
Upstream
|
Downstream
|
7
|
33
|
|
|
Effects on Modified Protein
- intracellular localization
|
|
Effects on Biological Processes:
|
|
|
Putative in vivo kinases:
|
|
Regulatory protein:
|
|
Treatment
- dasatinib
- etoposide
- H2O2
- imatinib
- mutation
- siRNA
|
|
|
PKCD (human)
|
STFDAHIyEGRVIQI
|
Y64-p
|
|
PKCD iso2 (human)
|
STFDAHIYEGRVIQI
|
Y64
|
|
PKCD (mouse)
|
TTFDAHIyEGRVIQI
|
Y64-p
|
|
PKCD iso2 (mouse)
|
TTFDAHIYEGRVIQI
|
Y64
|
|
PKCD (rat)
|
STFDAHIyEGRVIQI
|
Y64-p
|
|
|
K113
|
LDLQPQAKVLMCVQY
|
|
|
0
|
1
|
|
|
PKCD (human)
|
LDLQPQAkVLMSVQY
|
K113-sm
|
|
PKCD iso2 (human)
|
LDLQPQAKVLMSVQY
|
K113
|
|
PKCD (mouse)
|
LDLQPQAKVLMCVQY
|
K113
|
|
PKCD iso2 (mouse)
|
LDLQPQAKVLMCVQY
|
K113
|
|
PKCD (rat)
|
LDLQPQAKVLMCVQY
|
K113
|
|
|
S130-p
|
EDGDCKQsMRSEEEA
|
|
Downstream
|
1
|
10
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- phosphorylation
|
|
|
PKCD (human)
|
EDVDCKQsMRsEDEA
|
S130-p
|
|
PKCD iso2 (human)
|
EDVDCKQSMRSEDEA
|
S130
|
|
PKCD (mouse)
|
EDGDCKQsMRSEEEA
|
S130-p
|
|
PKCD iso2 (mouse)
|
EDGDCKQSMRSEEEA
|
S130
|
|
PKCD (rat)
|
EDGDCKQsMRSEEEA
|
S130-p
|
|
|
S133
|
DCKQsMRSEEEAMFP
|
|
|
0
|
1
|
|
|
PKCD (human)
|
DCKQsMRsEDEAkFP
|
S133-p
|
|
PKCD iso2 (human)
|
DCKQSMRSEDEAKFP
|
S133
|
|
PKCD (mouse)
|
DCKQsMRSEEEAKFP
|
S133
|
|
PKCD iso2 (mouse)
|
DCKQSMRSEEEAKFP
|
S133
|
|
PKCD (rat)
|
DCKQsMRSEEEAMFP
|
S133
|
|
|
M138
|
MRSEEEAMFPtMNRR
|
|
|
0
|
1
|
|
|
PKCD (human)
|
MRsEDEAkFPtMNRR
|
K138-ub
|
|
PKCD iso2 (human)
|
MRSEDEAKFPTMNRR
|
K138
|
|
PKCD (mouse)
|
MRSEEEAKFPtMNRR
|
K138
|
|
PKCD iso2 (mouse)
|
MRSEEEAKFPTMNRR
|
K138
|
|
PKCD (rat)
|
MRSEEEAMFPtMNRR
|
M138
|
|
|
T141-p
|
EEEAMFPtMNRRGAI
|
|
Downstream
|
2
|
10
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- phosphorylation
|
|
|
PKCD (human)
|
EDEAkFPtMNRRGAI
|
T141-p
|
|
PKCD iso2 (human)
|
EDEAKFPTMNRRGAI
|
T141
|
|
PKCD (mouse)
|
EEEAKFPtMNRRGAI
|
T141-p
|
|
PKCD iso2 (mouse)
|
EEEAKFPTMNRRGAI
|
T141
|
|
PKCD (rat)
|
EEEAMFPtMNRRGAI
|
T141-p
|
|
|
Y155-p
|
IKQAKIHyIKNHEFI
|
Upstream
|
Downstream
|
11
|
0
|
|
|
Effects on Modified Protein
- intracellular localization
- phosphorylation
|
|
Effects on Biological Processes:
|
|
|
Putative in vivo kinases:
|
|
Treatment
- dasatinib
- etoposide
- H2O2
- imatinib
- mutation
- siRNA
|
|
|
PKCD (human)
|
IKQAKIHyIKNHEFI
|
Y155-p
|
|
PKCD iso2 (human)
|
IKQAKIHYIKNHEFI
|
Y155
|
|
PKCD (mouse)
|
IKQAKIHyIKNHEFI
|
Y155-p
|
|
PKCD iso2 (mouse)
|
IKQAKIHYIKNHEFI
|
Y155
|
|
PKCD (rat)
|
IKQAKIHyIKNHEFI
|
Y155-p
|
|
|
T164-p
|
KNHEFIAtFFGQPTF
|
|
|
0
|
1
|
|
|
PKCD (human)
|
KNHEFIATFFGQPTF
|
T164
|
|
PKCD iso2 (human)
|
KNHEFIATFFGQPTF
|
T164
|
|
PKCD (mouse)
|
KNHEFIATFFGQPTF
|
T164
|
|
PKCD iso2 (mouse)
|
KNHEFIATFFGQPTF
|
T164
|
|
PKCD (rat)
|
KNHEFIAtFFGQPTF
|
T164-p
|
|
|
K184
|
EFVWGLNKQGYKCRQ
|
|
|
0
|
3
|
|
|
PKCD (human)
|
DFVWGLNkQGyKCRQ
|
K184-ub
|
|
PKCD iso2 (human)
|
DFVWGLNKQGYKCRQ
|
K184
|
|
PKCD (mouse)
|
EFVWGLNkQGyKCRQ
|
K184-ub
|
|
PKCD iso2 (mouse)
|
EFVWGLNKQGYKCRQ
|
K184
|
|
PKCD (rat)
|
EFVWGLNKQGYKCRQ
|
K184
|
|
|
Y187
|
WGLNKQGYKCRQCNA
|
|
|
6
|
0
|
|
|
PKCD (human)
|
WGLNkQGyKCRQCNA
|
Y187-p
|
|
PKCD iso2 (human)
|
WGLNKQGYKCRQCNA
|
Y187
|
|
PKCD (mouse)
|
WGLNkQGyKCRQCNA
|
Y187-p
|
|
PKCD iso2 (mouse)
|
WGLNKQGYKCRQCNA
|
Y187
|
|
PKCD (rat)
|
WGLNKQGYKCRQCNA
|
Y187
|
|
|
T211-p
|
IIGRCTGtAtNsRDt
|
|
|
0
|
1
|
|
|
PKCD (human)
|
IIGRCTGTAANSRDt
|
T211
|
|
PKCD iso2 (human)
|
IIGRCTGTAANSRDT
|
T211
|
|
PKCD (mouse)
|
IIGRCTGTATNSRDT
|
T211
|
|
PKCD iso2 (mouse)
|
IIGRCTGTATNSRDT
|
T211
|
|
PKCD (rat)
|
IIGRCTGtAtNsRDt
|
T211-p
|
|
|
T213-p
|
GRCTGtAtNsRDtIF
|
|
|
0
|
1
|
|
|
PKCD (human)
|
GRCTGTAANSRDtIF
|
A213
|
|
PKCD iso2 (human)
|
GRCTGTAANSRDTIF
|
A213
|
|
PKCD (mouse)
|
GRCTGTATNSRDTIF
|
T213
|
|
PKCD iso2 (mouse)
|
GRCTGTATNSRDTIF
|
T213
|
|
PKCD (rat)
|
GRCTGtAtNsRDtIF
|
T213-p
|
|
|
S215-p
|
CTGtAtNsRDtIFQK
|
|
|
0
|
1
|
|
|
PKCD (human)
|
CTGTAANSRDtIFQk
|
S215
|
|
PKCD iso2 (human)
|
CTGTAANSRDTIFQK
|
S215
|
|
PKCD (mouse)
|
CTGTATNSRDTIFQk
|
S215
|
|
PKCD iso2 (mouse)
|
CTGTATNSRDTIFQK
|
S215
|
|
PKCD (rat)
|
CTGtAtNsRDtIFQK
|
S215-p
|
|
|
T218-p
|
tAtNsRDtIFQKERF
|
|
|
1
|
8
|
|
|
PKCD (human)
|
TAANSRDtIFQkERF
|
T218-p
|
|
PKCD iso2 (human)
|
TAANSRDTIFQKERF
|
T218
|
|
PKCD (mouse)
|
TATNSRDTIFQkERF
|
T218
|
|
PKCD iso2 (mouse)
|
TATNSRDTIFQKERF
|
T218
|
|
PKCD (rat)
|
tAtNsRDtIFQKERF
|
T218-p
|
|
|
K222
|
sRDtIFQKERFNIDM
|
|
|
0
|
4
|
|
|
PKCD (human)
|
SRDtIFQkERFNIDM
|
K222-ub
|
|
PKCD iso2 (human)
|
SRDTIFQKERFNIDM
|
K222
|
|
PKCD (mouse)
|
SRDTIFQkERFNIDM
|
K222-ub
|
|
PKCD iso2 (mouse)
|
SRDTIFQKERFNIDM
|
K222
|
|
PKCD (rat)
|
sRDtIFQKERFNIDM
|
K222
|
|
|
Y236
|
MPHRFKVYNYMSPTF
|
|
|
0
|
2
|
|
|
PKCD (human)
|
MPHRFKVHNYMSPTF
|
H236
|
|
PKCD iso2 (human)
|
MPHRFKVHNYMSPTF
|
H236
|
|
PKCD (mouse)
|
MPHRFKVyNYMSPTF
|
Y236-p
|
|
PKCD iso2 (mouse)
|
MPHRFKVYNYMSPTF
|
Y236
|
|
PKCD (rat)
|
MPHRFKVYNYMSPTF
|
Y236
|
|
|
K271
|
CGMNVHHKCREKVAN
|
|
|
0
|
1
|
|
|
PKCD (human)
|
CGMNVHHkCREKVAN
|
K271-ub
|
|
PKCD iso2 (human)
|
CGMNVHHKCREKVAN
|
K271
|
|
PKCD (mouse)
|
CGMNVHHKCREKVAN
|
K271
|
|
PKCD iso2 (mouse)
|
CGMNVHHKCREKVAN
|
K271
|
|
PKCD (rat)
|
CGMNVHHKCREKVAN
|
K271
|
|
|
T295-p
|
AEALNQVtQKAsRKP
|
|
|
3
|
6
|
|
|
PKCD (human)
|
AEALNQVtQRAsRRs
|
T295-p
|
|
PKCD iso2 (human)
|
AEALNQVTQRASRRS
|
T295
|
|
PKCD (mouse)
|
AEALNQVTQRSSRkL
|
T295
|
|
PKCD iso2 (mouse)
|
AEALNQVTQRSSRKL
|
T295
|
|
PKCD (rat)
|
AEALNQVtQKAsRKP
|
T295-p
|
|
|
T295-gl
|
AEALNQVtQKAsRKP
|
|
|
0
|
1
|
|
|
PKCD (human)
|
AEALNQVTQRAsRRs
|
T295
|
|
PKCD iso2 (human)
|
AEALNQVTQRASRRS
|
T295
|
|
PKCD (mouse)
|
AEALNQVTQRSSRkL
|
T295
|
|
PKCD iso2 (mouse)
|
AEALNQVTQRSSRKL
|
T295
|
|
PKCD (rat)
|
AEALNQVtQKAsRKP
|
T295-gl
|
|
|
S299-p
|
NQVtQKAsRKPETPE
|
|
|
1
|
39
|
|
|
PKCD (human)
|
NQVtQRAsRRsDsAs
|
S299-p
|
|
PKCD iso2 (human)
|
NQVTQRASRRSDSAS
|
S299
|
|
PKCD (mouse)
|
NQVTQRSSRkLDTTE
|
S299
|
|
PKCD iso2 (mouse)
|
NQVTQRSSRKLDTTE
|
S299
|
|
PKCD (rat)
|
NQVtQKAsRKPETPE
|
S299-p
|
|
|
K301
|
VtQKAsRKPETPETV
|
|
|
0
|
1
|
|
|
PKCD (human)
|
VtQRAsRRsDsAssE
|
R301
|
|
PKCD iso2 (human)
|
VTQRASRRSDSASSE
|
R301
|
|
PKCD (mouse)
|
VTQRSSRkLDTTEsV
|
K301-ub
|
|
PKCD iso2 (mouse)
|
VTQRSSRKLDTTESV
|
K301
|
|
PKCD (rat)
|
VtQKAsRKPETPETV
|
K301
|
|
|
-
|
gap
|
|
|
2
|
74
|
|
|
|
|
-
|
gap
|
|
|
2
|
385
|
|
|
|
|
T304
|
KAsRKPETPETVGIy
|
|
|
0
|
80
|
|
|
PKCD (human)
|
sRRsDsAssEPVGIy
|
S306-p
|
|
PKCD iso2 (human)
|
SRRSDSASSEPVGIY
|
S306
|
|
PKCD (mouse)
|
RSSRkLDTTEsVGIy
|
T304
|
|
PKCD iso2 (mouse)
|
RSSRKLDTTESVGIY
|
T304
|
|
PKCD (rat)
|
KAsRKPETPETVGIy
|
T304
|
|
|
P305
|
AsRKPETPETVGIyQ
|
|
|
0
|
55
|
|
|
PKCD (human)
|
RRsDsAssEPVGIyQ
|
S307-p
|
|
PKCD iso2 (human)
|
RRSDSASSEPVGIYQ
|
S307
|
|
PKCD (mouse)
|
SSRkLDTTEsVGIyQ
|
T305
|
|
PKCD iso2 (mouse)
|
SSRKLDTTESVGIYQ
|
T305
|
|
PKCD (rat)
|
AsRKPETPETVGIyQ
|
P305
|
|
|
T307
|
RKPETPETVGIyQGF
|
|
|
0
|
4
|
|
|
PKCD (human)
|
sDsAssEPVGIyQGF
|
P309
|
|
PKCD iso2 (human)
|
SDSASSEPVGIYQGF
|
P309
|
|
PKCD (mouse)
|
RkLDTTEsVGIyQGF
|
S307-p
|
|
PKCD iso2 (mouse)
|
RKLDTTESVGIYQGF
|
S307
|
|
PKCD (rat)
|
RKPETPETVGIyQGF
|
T307
|
|
|
Y311-p
|
TPETVGIyQGFEKKT
|
Upstream
|
Downstream
|
35
|
1762
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- protein degradation
|
|
Effects on Biological Processes:
|
|
|
Kinase, in vitro:
- EGFR (human)
- Lck (mouse)
- Src (human)
- Src (rat)
|
|
Putative in vivo kinases:
|
|
Regulatory protein:
|
|
Treatment
- AG1478
- ceramide
- curcumin
- dasatinib
- EGF
- GF109203X
- H2O2
- herbimycin_A
- imatinib
- mutation
- PD153035
- peptide inhibitor
- phorbol_ester
- PP1
- PP2
- siRNA
- vanadate
|
|
|
PKCD (human)
|
ssEPVGIyQGFEKkT
|
Y313-p
|
|
PKCD iso2 (human)
|
SSEPVGIYQGFEKKT
|
Y313
|
|
PKCD (mouse)
|
TTEsVGIyQGFEKKP
|
Y311-p
|
|
PKCD iso2 (mouse)
|
TTESVGIYQGFEKKP
|
Y311
|
|
PKCD (rat)
|
TPETVGIyQGFEKKT
|
Y311-p
|
|
|
K317
|
IyQGFEKKTAVSGND
|
|
|
0
|
1
|
|
|
PKCD (human)
|
IyQGFEKkTGVAGED
|
K319-ub
|
|
PKCD iso2 (human)
|
IYQGFEKKTGVAGED
|
K319
|
|
PKCD (mouse)
|
IyQGFEKKPEVsGsD
|
K317
|
|
PKCD iso2 (mouse)
|
IYQGFEKKPEVSGSD
|
K317
|
|
PKCD (rat)
|
IyQGFEKKTAVSGND
|
K317
|
|
|
S321
|
FEKKTAVSGNDIPDN
|
|
|
0
|
1
|
|
|
PKCD (human)
|
FEKkTGVAGEDMQDN
|
A323
|
|
PKCD iso2 (human)
|
FEKKTGVAGEDMQGE
|
A323
|
|
PKCD (mouse)
|
FEKKPEVsGsDILDN
|
S321-p
|
|
PKCD iso2 (mouse)
|
FEKKPEVSGSDILGE
|
S321
|
|
PKCD (rat)
|
FEKKTAVSGNDIPDN
|
S321
|
|
|
-
|
gap
|
|
|
0
|
1
|
|
|
|
|
N329
|
GNDIPDNNGTyGKIW
|
|
|
0
|
6
|
|
|
PKCD (human)
|
GEDMQDNsGtyGkIW
|
S331-p
|
|
PKCD iso2 (human)
|
CQVRQDNSGTYGKIW
|
S362
|
|
PKCD (mouse)
|
GsDILDNNGTyGKIW
|
N329
|
|
PKCD iso2 (mouse)
|
SSETCDNNGTYGKIW
|
N355
|
|
PKCD (rat)
|
GNDIPDNNGTyGKIW
|
N329
|
|
|
T331
|
DIPDNNGTyGKIWEG
|
|
|
0
|
19
|
|
|
PKCD (human)
|
DMQDNsGtyGkIWEG
|
T333-p
|
|
PKCD iso2 (human)
|
VRQDNSGTYGKIWEG
|
T364
|
|
PKCD (mouse)
|
DILDNNGTyGKIWEG
|
T331
|
|
PKCD iso2 (mouse)
|
ETCDNNGTYGKIWEG
|
T357
|
|
PKCD (rat)
|
DIPDNNGTyGKIWEG
|
T331
|
|
|
Y332-p
|
IPDNNGTyGKIWEGS
|
Upstream
|
Downstream
|
13
|
554
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- molecular association, regulation
|
|
Effects on Biological Processes:
|
|
|
Kinase, in vitro:
- EGFR (human)
- Src (human)
- Src (rat)
|
|
Treatment
- AG1478
- ceramide
- EGF
- H2O2
- herbimycin_A
- PD153035
- PP1
- PP2
|
|
|
PKCD (human)
|
MQDNsGtyGkIWEGs
|
Y334-p
|
|
PKCD iso2 (human)
|
RQDNSGTYGKIWEGS
|
Y365
|
|
PKCD (mouse)
|
ILDNNGTyGKIWEGS
|
Y332-p
|
|
PKCD iso2 (mouse)
|
TCDNNGTYGKIWEGS
|
Y358
|
|
PKCD (rat)
|
IPDNNGTyGKIWEGS
|
Y332-p
|
|
|
K334
|
DNNGTyGKIWEGSNR
|
|
|
0
|
1
|
|
|
PKCD (human)
|
DNsGtyGkIWEGssK
|
K336-ub
|
|
PKCD iso2 (human)
|
DNSGTYGKIWEGSSK
|
K367
|
|
PKCD (mouse)
|
DNNGTyGKIWEGSTR
|
K334
|
|
PKCD iso2 (mouse)
|
DNNGTYGKIWEGSTR
|
K360
|
|
PKCD (rat)
|
DNNGTyGKIWEGSNR
|
K334
|
|
|
S339
|
yGKIWEGSNRCRLEN
|
|
|
0
|
2
|
|
|
PKCD (human)
|
yGkIWEGssKCNINN
|
S341-p
|
|
PKCD iso2 (human)
|
YGKIWEGSSKCNINN
|
S372
|
|
PKCD (mouse)
|
yGKIWEGSTRCTLEN
|
S339
|
|
PKCD iso2 (mouse)
|
YGKIWEGSTRCTLEN
|
S365
|
|
PKCD (rat)
|
yGKIWEGSNRCRLEN
|
S339
|
|
|
N340
|
GKIWEGSNRCRLENF
|
|
|
0
|
1
|
|
|
PKCD (human)
|
GkIWEGssKCNINNF
|
S342-p
|
|
PKCD iso2 (human)
|
GKIWEGSSKCNINNF
|
S373
|
|
PKCD (mouse)
|
GKIWEGSTRCTLENF
|
T340
|
|
PKCD iso2 (mouse)
|
GKIWEGSTRCTLENF
|
T366
|
|
PKCD (rat)
|
GKIWEGSNRCRLENF
|
N340
|
|
|
T348-gl
|
RCRLENFtFQKVLGK
|
|
|
0
|
1
|
|
|
PKCD (human)
|
KCNINNFIFHKVLGK
|
I350
|
|
PKCD iso2 (human)
|
KCNINNFIFHKVLGK
|
I381
|
|
PKCD (mouse)
|
RCTLENFTFQKVLGK
|
T348
|
|
PKCD iso2 (mouse)
|
RCTLENFTFQKVLGK
|
T374
|
|
PKCD (rat)
|
RCRLENFtFQKVLGK
|
T348-gl
|
|
|
S357-p
|
QKVLGKGsFGKVLLA
|
Upstream
|
|
3
|
2
|
|
|
|
|
|
|
PKCD (human)
|
HKVLGKGsFGkVLLG
|
S359-p
|
|
PKCD iso2 (human)
|
HKVLGKGSFGKVLLG
|
S390
|
|
PKCD (mouse)
|
QKVLGKGSFGKVLLA
|
S357
|
|
PKCD iso2 (mouse)
|
QKVLGKGSFGKVLLA
|
S383
|
|
PKCD (rat)
|
QKVLGKGsFGKVLLA
|
S357-p
|
|
|
K360
|
LGKGsFGKVLLAELK
|
|
|
0
|
1
|
|
|
PKCD (human)
|
LGKGsFGkVLLGELk
|
K362-ub
|
|
PKCD iso2 (human)
|
LGKGSFGKVLLGELK
|
K393
|
|
PKCD (mouse)
|
LGKGSFGKVLLAELK
|
K360
|
|
PKCD iso2 (mouse)
|
LGKGSFGKVLLAELK
|
K386
|
|
PKCD (rat)
|
LGKGsFGKVLLAELK
|
K360
|
|
|
K367
|
KVLLAELKGKERyFA
|
|
|
0
|
6
|
|
|
PKCD (human)
|
kVLLGELkGRGEyFA
|
K369-ub
|
|
PKCD iso2 (human)
|
KVLLGELKGRGEYFA
|
K400
|
|
PKCD (mouse)
|
KVLLAELKGKDKyFA
|
K367
|
|
PKCD iso2 (mouse)
|
KVLLAELKGKDKYFA
|
K393
|
|
PKCD (rat)
|
KVLLAELKGKERyFA
|
K367
|
|
|
Y372-p
|
ELKGKERyFAIKYLK
|
Upstream
|
|
2
|
545
|
|
|
Putative in vivo kinases:
|
|
|
PKCD (human)
|
ELkGRGEyFAIKALK
|
Y374-p
|
|
PKCD iso2 (human)
|
ELKGRGEYFAIKALK
|
Y405
|
|
PKCD (mouse)
|
ELKGKDKyFAIKCLK
|
Y372-p
|
|
PKCD iso2 (mouse)
|
ELKGKDKYFAIKCLK
|
Y398
|
|
PKCD (rat)
|
ELKGKERyFAIKYLK
|
Y372-p
|
|
|
Y446
|
DKGRFELYRATFYAA
|
|
|
0
|
1
|
|
|
PKCD (human)
|
DKGRFELyRAtFyAA
|
Y448-p
|
|
PKCD iso2 (human)
|
DKGRFELYRATFYAA
|
Y479
|
|
PKCD (mouse)
|
DKGRFELYRATFYAA
|
Y446
|
|
PKCD iso2 (mouse)
|
DKGRFELYRATFYAA
|
Y472
|
|
PKCD (rat)
|
DKGRFELYRATFYAA
|
Y446
|
|
|
T449
|
RFELYRATFYAAEII
|
|
|
0
|
1
|
|
|
PKCD (human)
|
RFELyRAtFyAAEIM
|
T451-p
|
|
PKCD iso2 (human)
|
RFELYRATFYAAEIM
|
T482
|
|
PKCD (mouse)
|
RFELYRATFYAAEII
|
T449
|
|
PKCD iso2 (mouse)
|
RFELYRATFYAAEII
|
T475
|
|
PKCD (rat)
|
RFELYRATFYAAEII
|
T449
|
|
|
Y451
|
ELYRATFYAAEIICG
|
|
|
0
|
1
|
|
|
PKCD (human)
|
ELyRAtFyAAEIMCG
|
Y453-p
|
|
PKCD iso2 (human)
|
ELYRATFYAAEIMCG
|
Y484
|
|
PKCD (mouse)
|
ELYRATFYAAEIICG
|
Y451
|
|
PKCD iso2 (mouse)
|
ELYRATFYAAEIICG
|
Y477
|
|
PKCD (rat)
|
ELYRATFYAAEIICG
|
Y451
|
|
|
Y469
|
LHGKGIIYRDLKLDN
|
|
|
0
|
1
|
|
|
PKCD (human)
|
LHSKGIIyRDLKLDN
|
Y471-p
|
|
PKCD iso2 (human)
|
LHSKGIIYRDLKLDN
|
Y502
|
|
PKCD (mouse)
|
LHSKGIIYrDLKLDN
|
Y469
|
|
PKCD iso2 (mouse)
|
LHSKGIIYRDLKLDN
|
Y495
|
|
PKCD (rat)
|
LHGKGIIYRDLKLDN
|
Y469
|
|
|
R470
|
HGKGIIYRDLKLDNV
|
|
|
0
|
2
|
|
|
PKCD (human)
|
HSKGIIyRDLKLDNV
|
R472
|
|
PKCD iso2 (human)
|
HSKGIIYRDLKLDNV
|
R503
|
|
PKCD (mouse)
|
HSKGIIYrDLKLDNV
|
R470-m1
|
|
PKCD iso2 (mouse)
|
HSKGIIYRDLKLDNV
|
R496
|
|
PKCD (rat)
|
HGKGIIYRDLKLDNV
|
R470
|
|
|
K494
|
IADFGMCKENIFGEN
|
|
|
0
|
5
|
|
|
PKCD (human)
|
IADFGMCkENIFGEs
|
K496-ub
|
|
PKCD iso2 (human)
|
IADFGMCKENIFGES
|
K527
|
|
PKCD (mouse)
|
IADFGMCKENIFGEG
|
K494
|
|
PKCD iso2 (mouse)
|
IADFGMCKENIFGEG
|
K520
|
|
PKCD (rat)
|
IADFGMCKENIFGEN
|
K494
|
|
|
N501
|
KENIFGENRAstFCG
|
|
|
1
|
16
|
|
|
PKCD (human)
|
kENIFGEsRAstFCG
|
S503-p
|
|
PKCD iso2 (human)
|
KENIFGESRASTFCG
|
S534
|
|
PKCD (mouse)
|
KENIFGEGRAstFCG
|
G501
|
|
PKCD iso2 (mouse)
|
KENIFGEGRASTFCG
|
G527
|
|
PKCD (rat)
|
KENIFGENRAstFCG
|
N501
|
|
|
S504-p
|
IFGENRAstFCGTPD
|
|
|
0
|
57
|
|
|
PKCD (human)
|
IFGEsRAstFCGtPD
|
S506-p
|
|
PKCD iso2 (human)
|
IFGESRASTFCGTPD
|
S537
|
|
PKCD (mouse)
|
IFGEGRAstFCGtPD
|
S504-p
|
|
PKCD iso2 (mouse)
|
IFGEGRASTFCGTPD
|
S530
|
|
PKCD (rat)
|
IFGENRAstFCGTPD
|
S504-p
|
|
|
T505-p
|
FGENRAstFCGTPDy
|
Upstream
|
Downstream
|
42
|
128
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
|
|
Kinase, in vitro:
|
|
Phosphatases, in vitro:
|
|
Putative in vivo kinases:
- PDK1 (human)
- PKCE (mouse)
|
|
Regulatory protein:
|
|
Treatment
- carbachol
- EGF
- endothelin
- GF109203X
- Go_6976
- H-CHO
- H2O2
- insulin
- isoproterenol
- leucine
- LY294002
- meal feeding
- norepinephrine
- norleucine
- Pasteurella_multocida_toxin
- PDGF
- phorbol_ester
- PP2
- prazosin
- propranolol
- rapamycin
- streptozotocin
- thrombin
- U0126
- UCN-01
- wortmannin
|
|
|
PKCD (human)
|
FGEsRAstFCGtPDy
|
T507-p
|
|
PKCD iso2 (human)
|
FGESRASTFCGTPDY
|
T538
|
|
PKCD (mouse)
|
FGEGRAstFCGtPDY
|
T505-p
|
|
PKCD iso2 (mouse)
|
FGEGRASTFCGTPDY
|
T531
|
|
PKCD (rat)
|
FGENRAstFCGTPDy
|
T505-p
|
|
|
T509
|
RAstFCGTPDyIAPE
|
|
|
0
|
9
|
|
|
PKCD (human)
|
RAstFCGtPDyIAPE
|
T511-p
|
|
PKCD iso2 (human)
|
RASTFCGTPDYIAPE
|
T542
|
|
PKCD (mouse)
|
RAstFCGtPDYIAPE
|
T509-p
|
|
PKCD iso2 (mouse)
|
RASTFCGTPDYIAPE
|
T535
|
|
PKCD (rat)
|
RAstFCGTPDyIAPE
|
T509
|
|
|
Y512-p
|
tFCGTPDyIAPEILQ
|
Upstream
|
Downstream
|
3
|
3
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
|
|
|
|
PKCD (human)
|
tFCGtPDyIAPEILQ
|
Y514-p
|
|
PKCD iso2 (human)
|
TFCGTPDYIAPEILQ
|
Y545
|
|
PKCD (mouse)
|
tFCGtPDYIAPEILQ
|
Y512
|
|
PKCD iso2 (mouse)
|
TFCGTPDYIAPEILQ
|
Y538
|
|
PKCD (rat)
|
tFCGTPDyIAPEILQ
|
Y512-p
|
|
|
Y523-p
|
EILQGLKySFSVDWW
|
Upstream
|
Downstream
|
4
|
0
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
|
|
|
|
PKCD (human)
|
EILQGLKyTFSVDWW
|
Y525-p
|
|
PKCD iso2 (human)
|
EILQGLKYTFSVDWW
|
Y556
|
|
PKCD (mouse)
|
EILQGLKySFSVDWW
|
Y523-p
|
|
PKCD iso2 (mouse)
|
EILQGLKYSFSVDWW
|
Y549
|
|
PKCD (rat)
|
EILQGLKySFSVDWW
|
Y523-p
|
|
|
Y565-p
|
IRVDTPHyPRWITKE
|
Upstream
|
|
5
|
0
|
|
|
Putative in vivo kinases:
|
|
|
PKCD (human)
|
IRVDTPHyPRWITKE
|
Y567-p
|
|
PKCD iso2 (human)
|
IRVDTPHYPRWITKE
|
Y598
|
|
PKCD (mouse)
|
IRVDTPHyPRWITKE
|
Y565-p
|
|
PKCD iso2 (mouse)
|
IRVDTPHYPRWITKE
|
Y591
|
|
PKCD (rat)
|
IRVDTPHyPRWITKE
|
Y565-p
|
|
|
K579
|
ESKDIMEKLFERDPA
|
|
|
0
|
1
|
|
|
PKCD (human)
|
ESKDILEkLFEREPT
|
K581-ub
|
|
PKCD iso2 (human)
|
ESKDILEKLFEREPT
|
K612
|
|
PKCD (mouse)
|
ESKDIMEKLFERDPD
|
K579
|
|
PKCD iso2 (mouse)
|
ESKDIMEKLFERDPD
|
K605
|
|
PKCD (rat)
|
ESKDIMEKLFERDPA
|
K579
|
|
|
T592
|
PAKRLGVTGNIRLHP
|
|
|
0
|
1
|
|
|
PKCD (human)
|
PTKRLGVtGNIKIHP
|
T594-p
|
|
PKCD iso2 (human)
|
PTKRLGVTGNIKIHP
|
T625
|
|
PKCD (mouse)
|
PDKRLGVTGNIRIHP
|
T592
|
|
PKCD iso2 (mouse)
|
PDKRLGVTGNIRIHP
|
T618
|
|
PKCD (rat)
|
PAKRLGVTGNIRLHP
|
T592
|
|
|
T592-gl
|
PAKRLGVtGNIRLHP
|
|
|
0
|
1
|
|
|
PKCD (human)
|
PTKRLGVTGNIKIHP
|
T594
|
|
PKCD iso2 (human)
|
PTKRLGVTGNIKIHP
|
T625
|
|
PKCD (mouse)
|
PDKRLGVTGNIRIHP
|
T592
|
|
PKCD iso2 (mouse)
|
PDKRLGVTGNIRIHP
|
T618
|
|
PKCD (rat)
|
PAKRLGVtGNIRLHP
|
T592-gl
|
|
|
T603
|
RLHPFFKTINWNLLE
|
|
|
0
|
1
|
|
|
PKCD (human)
|
KIHPFFKtINWtLLE
|
T605-p
|
|
PKCD iso2 (human)
|
KIHPFFKTINWTLLE
|
T636
|
|
PKCD (mouse)
|
RIHPFFKTINWSLLE
|
T603
|
|
PKCD iso2 (mouse)
|
RIHPFFKTINWSLLE
|
T629
|
|
PKCD (rat)
|
RLHPFFKTINWNLLE
|
T603
|
|
|
N607
|
FFKTINWNLLEKRKV
|
|
|
0
|
2
|
|
|
PKCD (human)
|
FFKtINWtLLEkRRL
|
T609-p
|
|
PKCD iso2 (human)
|
FFKTINWTLLEKRRL
|
T640
|
|
PKCD (mouse)
|
FFKTINWSLLEKRKV
|
S607
|
|
PKCD iso2 (mouse)
|
FFKTINWSLLEKRKV
|
S633
|
|
PKCD (rat)
|
FFKTINWNLLEKRKV
|
N607
|
|
|
K611
|
INWNLLEKRKVEPPF
|
|
|
0
|
1
|
|
|
PKCD (human)
|
INWtLLEkRRLEPPF
|
K613-ub
|
|
PKCD iso2 (human)
|
INWTLLEKRRLEPPF
|
K644
|
|
PKCD (mouse)
|
INWSLLEKRKVEPPF
|
K611
|
|
PKCD iso2 (mouse)
|
INWSLLEKRKVEPPF
|
K637
|
|
PKCD (rat)
|
INWNLLEKRKVEPPF
|
K611
|
|
|
Y628-p
|
KVKSPSDySNFDPEF
|
Upstream
|
|
1
|
29
|
|
|
Putative in vivo kinases:
|
|
|
PKCD (human)
|
KVKSPRDysNFDQEF
|
Y630-p
|
|
PKCD iso2 (human)
|
KVKSPRDYSNFDQEF
|
Y661
|
|
PKCD (mouse)
|
KVKSPSDYSNFDPEF
|
Y628
|
|
PKCD iso2 (mouse)
|
KVKSPSDYSNFDPEF
|
Y654
|
|
PKCD (rat)
|
KVKSPSDySNFDPEF
|
Y628-p
|
|
|
S629
|
VKSPSDySNFDPEFL
|
|
|
0
|
1
|
|
|
PKCD (human)
|
VKSPRDysNFDQEFL
|
S631-p
|
|
PKCD iso2 (human)
|
VKSPRDYSNFDQEFL
|
S662
|
|
PKCD (mouse)
|
VKSPSDYSNFDPEFL
|
S629
|
|
PKCD iso2 (mouse)
|
VKSPSDYSNFDPEFL
|
S655
|
|
PKCD (rat)
|
VKSPSDySNFDPEFL
|
S629
|
|
|
K639
|
DPEFLNEKPQLsFsD
|
|
|
0
|
7
|
|
|
PKCD (human)
|
DQEFLNEkARLsysD
|
K641-ub
|
|
PKCD iso2 (human)
|
DQEFLNEKARLSYSD
|
K672
|
|
PKCD (mouse)
|
DPEFLNEKPQLsFsD
|
K639
|
|
PKCD iso2 (mouse)
|
DPEFLNEKPQLSFSD
|
K665
|
|
PKCD (rat)
|
DPEFLNEKPQLsFsD
|
K639
|
|
|
S643-p
|
LNEKPQLsFsDKNLI
|
Upstream
|
Downstream
|
23
|
129
|
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
|
|
Regulatory protein:
|
|
Treatment
- cytochalasin_D
- endothelin
- fibronectin
- GF109203X
- H-CHO
- H2O2
- insulin
- KBR
- leucine
- LY294002
- meal feeding
- norleucine
- OXO
- phorbol_ester
- PP2
- serum
- sevoflurane
|
|
|
PKCD (human)
|
LNEkARLsysDKNLI
|
S645-p
|
|
PKCD iso2 (human)
|
LNEKARLSYSDKNLI
|
S676
|
|
PKCD (mouse)
|
LNEKPQLsFsDKNLI
|
S643-p
|
|
PKCD iso2 (mouse)
|
LNEKPQLSFSDKNLI
|
S669
|
|
PKCD (rat)
|
LNEKPQLsFsDKNLI
|
S643-p
|
|
|
F644
|
NEKPQLsFsDKNLID
|
|
|
0
|
24
|
|
|
PKCD (human)
|
NEkARLsysDKNLID
|
Y646-p
|
|
PKCD iso2 (human)
|
NEKARLSYSDKNLID
|
Y677
|
|
PKCD (mouse)
|
NEKPQLsFsDKNLID
|
F644
|
|
PKCD iso2 (mouse)
|
NEKPQLSFSDKNLID
|
F670
|
|
PKCD (rat)
|
NEKPQLsFsDKNLID
|
F644
|
|
|
S645-p
|
EKPQLsFsDKNLIDS
|
|
|
0
|
57
|
|
|
PKCD (human)
|
EkARLsysDKNLIDs
|
S647-p
|
|
PKCD iso2 (human)
|
EKARLSYSDKNLIDS
|
S678
|
|
PKCD (mouse)
|
EKPQLsFsDKNLIDs
|
S645-p
|
|
PKCD iso2 (mouse)
|
EKPQLSFSDKNLIDS
|
S671
|
|
PKCD (rat)
|
EKPQLsFsDKNLIDS
|
S645-p
|
|
|
S652
|
sDKNLIDSMDQtAFK
|
|
|
0
|
14
|
|
|
PKCD (human)
|
sDKNLIDsMDQsAFA
|
S654-p
|
|
PKCD iso2 (human)
|
SDKNLIDSMDQSAFA
|
S685
|
|
PKCD (mouse)
|
sDKNLIDsMDQEAFH
|
S652-p
|
|
PKCD iso2 (mouse)
|
SDKNLIDSMDQEAFH
|
S678
|
|
PKCD (rat)
|
sDKNLIDSMDQtAFK
|
S652
|
|
|
T656-p
|
LIDSMDQtAFKGFsF
|
|
|
0
|
7
|
|
|
PKCD (human)
|
LIDsMDQsAFAGFsF
|
S658-p
|
|
PKCD iso2 (human)
|
LIDSMDQSAFAGFSF
|
S689
|
|
PKCD (mouse)
|
LIDsMDQEAFHGFsF
|
E656
|
|
PKCD iso2 (mouse)
|
LIDSMDQEAFHGFSF
|
E682
|
|
PKCD (rat)
|
LIDSMDQtAFKGFsF
|
T656-p
|
|
|
S662-p
|
QtAFKGFsFVNPKYE
|
Upstream
|
|
10
|
133
|
|
|
|
|
Phosphatases, in vitro:
|
|
Putative in vivo kinases:
|
|
Treatment
- carbachol
- H2O2
- LY294002
- phorbol_ester
- racepinefrine
- rapamycin
- wortmannin
|
|
|
PKCD (human)
|
QsAFAGFsFVNPKFE
|
S664-p
|
|
PKCD iso2 (human)
|
QSAFAGFSFVNPKFE
|
S695
|
|
PKCD (mouse)
|
QEAFHGFsFVNPKFE
|
S662-p
|
|
PKCD iso2 (mouse)
|
QEAFHGFSFVNPKFE
|
S688
|
|
PKCD (rat)
|
QtAFKGFsFVNPKYE
|
S662-p
|
|
