Other Species / Isoforms
  IRS1 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S3-p
_____MAsPPDtDGF
Upstream
0 22
Treatment
  • insulin
  • LY294002
IRS1 (human) _____MAsPPEsDGF S3-p
IRS1 (mouse) _____MAsPPDtDGF S3-p
IRS1 (rat) _____MAsPPDTDGF S3-p
T7-p
_MAsPPDtDGFSDVR
0 2
IRS1 (human) _MAsPPEsDGFSDVR S7-p
IRS1 (mouse) _MAsPPDtDGFSDVR T7-p
IRS1 (rat) _MAsPPDTDGFSDVR T7
S24
GYLRKPKSMHKRFFV
2 2
IRS1 (human) GYLRKPKsMHKRFFV S24-p
IRS1 (mouse) GYLRKPKSMHKRFFV S24
IRS1 (rat) GYLRKPKsMHKRFFV S24-p
Y46-p
GGPARLEyyENEKKW
1 27
IRS1 (human) GGPARLEyyENEKkW Y46-p
IRS1 (mouse) GGPARLEyyENEKKW Y46-p
IRS1 (rat) GGPARLEYYENEKKW Y46
Y47-p
GPARLEyyENEKKWR
0 4
IRS1 (human) GPARLEyyENEKkWR Y47-p
IRS1 (mouse) GPARLEyyENEKKWR Y47-p
IRS1 (rat) GPARLEYYENEKKWR Y47
K52
EyyENEKKWRHKSSA
0 1
IRS1 (human) EyyENEKkWRHKSSA K52-ac
IRS1 (mouse) EyyENEKKWRHKSSA K52
IRS1 (rat) EYYENEKKWRHKSSA K52
K61
RHKSSAPKRSIPLES
0 1
IRS1 (human) RHKSSAPkRSIPLES K61-ac
IRS1 (mouse) RHKSSAPKRSIPLES K61
IRS1 (rat) RHKSSAPKRSIPLES K61
Y87
NKHLVALYTRDEHFA
0 6
IRS1 (human) NKHLVALyTRDEHFA Y87-p
IRS1 (mouse) NKHLVALYTRDEHFA Y87
IRS1 (rat) NKHLVALYTRDEHFA Y87
S99-p
HFAIAADsEAEQDSW
Upstream
1 1
Treatment
  • insulin
IRS1 (human) HFAIAADSEAEQDSW S99
IRS1 (mouse) HFAIAADsEAEQDSW S99-p
IRS1 (rat) HFAIAADsEAEQDSW S99-p
Y107
EAEQDSWYQALLQLH
0 1
IRS1 (human) EAEQDSWyQALLQLH Y107-p
IRS1 (mouse) EAEQDSWYQALLQLH Y107
IRS1 (rat) EAEQDSWYQALLQLH Y107
S131-p
AGGGCGGsCSGSSGV
Upstream
0 1
Treatment
  • insulin
IRS1 (human) GAGGGGGSCSGSSGL S135
IRS1 (mouse) AGGGCGGsCSGSSGV S131-p
IRS1 (rat) AGGGCGGSCSGSSGV S131
Y147-p
EAGEDLSyDTGPGPA
Upstream
0 2
Treatment
  • insulin
IRS1 (human) EAGEDLSYGDVPPGP Y151
IRS1 (mouse) EAGEDLSyDTGPGPA Y147-p
IRS1 (rat) EAGEDLSYDTGPGPA Y147
K164
EVWQVILKPKGLGQT
0 3
IRS1 (human) EVWQVILkPKGLGQT K169-ub
IRS1 (mouse) EVWQVILKPKGLGQT K164
IRS1 (rat) EVWQVILKPKGLGQT K164
Y178
TKNLIGIYRLCLTSK
0 1
IRS1 (human) TKNLIGIyRLCLTSK Y183-p
IRS1 (mouse) TKNLIGIYRLCLTSK Y178
IRS1 (rat) TKNLIGIYRLCLTSK Y178
S263
SDEFRPRSKsQssSs
0 3
IRS1 (human) SDEFRPRsKsQSssN S268-p
IRS1 (mouse) SDEFRPRSKsQssSs S263
IRS1 (rat) SDEFRPRTKsQSSSs T263
S265-p
EFRPRSKsQssSsCs
Upstream
7 45
Regulatory protein:
  • TSC1 (mouse)
Treatment
  • casein
  • IL-6
  • insulin
  • LY294002
  • MK-2206
  • rapamycin
  • TNF
  • Torin1
view more >
IRS1 (human) EFRPRsKsQSssNCs S270-p
IRS1 (mouse) EFRPRSKsQssSsCs S265-p
IRS1 (rat) EFRPRTKsQSSSsCS S265-p
S267-p
RPRSKsQssSsCsNP
Upstream
1 1
Treatment
  • insulin
IRS1 (human) RPRsKsQSssNCsNP S272
IRS1 (mouse) RPRSKsQssSsCsNP S267-p
IRS1 (rat) RPRTKsQSSSsCSNP S267
S268-p
PRSKsQssSsCsNPI
Upstream
0 2
Treatment
  • insulin
  • MK-2206
IRS1 (human) PRsKsQSssNCsNPI S273-p
IRS1 (mouse) PRSKsQssSsCsNPI S268-p
IRS1 (rat) PRTKsQSSSsCSNPI S268
S269
RSKsQssSsCsNPIS
0 1
IRS1 (human) RsKsQSssNCsNPIs S274-p
IRS1 (mouse) RSKsQssSsCsNPIS S269
IRS1 (rat) RTKsQSSSsCSNPIS S269
S270-p
SKsQssSsCsNPISV
Upstream
0 2
Treatment
  • insulin
  • MK-2206
IRS1 (human) sKsQSssNCsNPIsV N275
IRS1 (mouse) SKsQssSsCsNPISV S270-p
IRS1 (rat) TKsQSSSsCSNPISV S270-p
S272-p
sQssSsCsNPISVPL
Upstream
0 10
Treatment
  • insulin
IRS1 (human) sQSssNCsNPIsVPL S277-p
IRS1 (mouse) sQssSsCsNPISVPL S272-p
IRS1 (rat) sQSSSsCSNPISVPL S272
S276
SsCsNPISVPLRRHH
0 1
IRS1 (human) sNCsNPIsVPLRRHH S281-p
IRS1 (mouse) SsCsNPISVPLRRHH S276
IRS1 (rat) SsCSNPISVPLRRHH S276
S298
QVGLTRRSRtEsITA
1 4
IRS1 (human) QVGLTRRsRtEsItA S303-p
IRS1 (mouse) QVGLTRRSRtEsITA S298
IRS1 (rat) QVGLTRRSRTEsITA S298
T300-p
GLTRRSRtEsITAts
0 4
IRS1 (human) GLTRRsRtEsItAts T305-p
IRS1 (mouse) GLTRRSRtEsITAts T300-p
IRS1 (rat) GLTRRSRTEsITATs T300
S302-p
TRRSRtEsITAtsPA
Upstream
Downstream
60 13
IRS1 (human)
S307-p
IRS1 (mouse)
S302-p
IRS1 (rat)
S302-p
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell growth, altered
  • neural plasticity
  • signaling pathway regulation
Putative in vivo kinases:
  • mTOR (human)
  • ROCK1 (rat)
Regulatory protein:
  • DDIT4 (human)
  • DUSP4 (human)
  • FOXO1A (mouse)
  • IKKG (mouse)
  • MYO1C (mouse)
  • RICTOR (mouse)
  • Sin1 (human)
  • TSC1 (mouse)
view more >
Treatment
  • adiponectin
  • amino_acids
  • antibody
  • EGF
  • FGF2
  • GKT136901
  • glucose
  • GW501516
  • high-fat diet
  • high_glucose
  • HM-chromanone
  • IGF-1
  • insulin
  • JNK_inhibitor_I
  • LY294002
  • methyl-beta-cyclodextrin
  • MHY1485
  • MK-2206
  • NAC
  • okadaic_acid
  • palmitate
  • PD98059
  • PDGF
  • rapamycin
  • resveratrol
  • serum
  • serum_withdrawal
  • siRNA
  • SP600125
  • TNF
  • Torin1
  • Y27632
view more >
IRS1 (human) TRRsRtEsItAtsPA S307-p
IRS1 (mouse) TRRSRtEsITAtsPA S302-p
IRS1 (rat) TRRSRTEsITATsPA S302-p
T304
RSRtEsITAtsPAsM
0 4
IRS1 (human) RsRtEsItAtsPAsM T309-p
IRS1 (mouse) RSRtEsITAtsPAsM T304
IRS1 (rat) RSRTEsITATsPASM T304
T306-p
RtEsITAtsPAsMVG
0 4
IRS1 (human) RtEsItAtsPAsMVG T311-p
IRS1 (mouse) RtEsITAtsPAsMVG T306-p
IRS1 (rat) RTEsITATsPASMVG T306
S307-p
tEsITAtsPAsMVGG
Upstream
Downstream
89 15
IRS1 (human)
S312-p
IRS1 (mouse)
S307-p
IRS1 (rat)
S307-p
Effects on Modified Protein
  • phosphorylation
Effects on Biological Processes:
  • cell differentiation, inhibited
  • neural plasticity
  • signaling pathway regulation
Kinase, in vitro:
  • JNK1 (rat)
  • PKR (mouse)
Putative in vivo kinases:
  • IKKA (mouse)
  • JNK1 (mouse)
  • mTOR (mouse)
  • PKR (human)
  • PKR (mouse)
view more >
Regulatory protein:
  • IRS1 (mouse)
  • JIP1 (mouse)
  • JNK1 (mouse)
  • Raptor (mouse)
  • RHEB (mouse)
  • RHOA (mouse)
  • ROCK1 (mouse)
  • SMTNL1 (human)
  • Syk (mouse)
view more >
Treatment
  • 15d-PGJ2
  • adiponectin
  • amino_acids
  • angiotensin_2
  • anisomycin
  • antibody
  • aspirin
  • bisindolylmaleimide
  • calphostin_C
  • CDDP
  • CRP
  • DPHC
  • endothelin
  • estradiol
  • free_fatty_acids
  • glucose
  • GSK650394
  • HA-1077
  • high-fat diet
  • hypoxia
  • hypoxia/reoxygenation
  • IGF-1
  • IKK_inhibitor_VII
  • IL-1b
  • IL-6
  • insulin
  • ischemia
  • JNK_inhibitor_I
  • LG268
  • linoleic_acid
  • liothyronine
  • LY294002
  • MK-2206
  • myriocin
  • NAC
  • obesity
  • okadaic_acid
  • osmotic_stress
  • palmitate
  • PD98059
  • phorbol_ester
  • piceatannol
  • rapamycin
  • rosiglitazone
  • SB203580
  • siRNA
  • SP600125
  • thapsigargin
  • TNF
  • Torin1
  • wortmannin
  • Y27632
view more >
IRS1 (human) tEsItAtsPAsMVGG S312-p
IRS1 (mouse) tEsITAtsPAsMVGG S307-p
IRS1 (rat) TEsITATsPASMVGG S307-p
S310-p
ITAtsPAsMVGGKPG
Upstream
0 3
Treatment
  • insulin
  • LY294002
IRS1 (human) ItAtsPAsMVGGKPG S315-p
IRS1 (mouse) ITAtsPAsMVGGKPG S310-p
IRS1 (rat) ITATsPASMVGGkPG S310
K315
PAsMVGGKPGsFRVR
0 1
IRS1 (human) PAsMVGGKPGsFRVR K320
IRS1 (mouse) PAsMVGGKPGsFRVR K315
IRS1 (rat) PASMVGGkPGsFRVR K315-ac
S318-p
MVGGKPGsFRVRASs
Upstream
Downstream
14 21
IRS1 (human)
S323-p
IRS1 (mouse)
S318-p
IRS1 (rat)
S318-p
Effects on Modified Protein
  • phosphorylation
Kinase, in vitro:
  • PKCA (human)
  • PKCB (human)
  • PKCE (human)
  • PKCT (human)
view more >
Putative in vivo kinases:
  • PKCD (mouse)
Regulatory protein:
  • PKCD (human)
Treatment
  • bisindolylmaleimide
  • IL-6
  • insulin
  • LY294002
  • phorbol_ester
  • PTH(1-34)
  • siRNA
view more >
IRS1 (human) MVGGKPGsFRVRAss S323-p
IRS1 (mouse) MVGGKPGsFRVRASs S318-p
IRS1 (rat) MVGGkPGsFRVRAss S318-p
S324
GsFRVRASsDGEGTM
0 4
IRS1 (human) GsFRVRAssDGEGtM S329-p
IRS1 (mouse) GsFRVRASsDGEGTM S324
IRS1 (rat) GsFRVRAssDGEGtM S324-p
S325-p
sFRVRASsDGEGTMs
Upstream
4 23
Treatment
  • insulin
IRS1 (human) sFRVRAssDGEGtMS S330-p
IRS1 (mouse) sFRVRASsDGEGTMs S325-p
IRS1 (rat) sFRVRAssDGEGtMs S325-p
T330
ASsDGEGTMsRPAsV
1 5
IRS1 (human) AssDGEGtMSRPAsV T335-p
IRS1 (mouse) ASsDGEGTMsRPAsV T330
IRS1 (rat) AssDGEGtMsRPAsV T330-p
S332-p
sDGEGTMsRPAsVDG
Upstream
3 1
IRS1 (human)
S337-p
IRS1 (mouse)
S332-p
IRS1 (rat)
S332-p
Treatment
  • insulin
  • LY294002
IRS1 (human) sDGEGtMSRPAsVDG S337
IRS1 (mouse) sDGEGTMsRPAsVDG S332-p
IRS1 (rat) sDGEGtMsRPAsVDG S332-p
S336-p
GTMsRPAsVDGsPVs
Upstream
4 15
IRS1 (human)
S341-p
IRS1 (mouse)
S336-p
IRS1 (rat)
S336-p
Treatment
  • insulin
  • MK-2206
IRS1 (human) GtMSRPAsVDGsPVs S341-p
IRS1 (mouse) GTMsRPAsVDGsPVs S336-p
IRS1 (rat) GtMsRPAsVDGSPVs S336-p
S340-p
RPAsVDGsPVsPSTN
Upstream
0 14
Treatment
  • insulin
  • PTH(1-34)
IRS1 (human) RPAsVDGsPVsPstN S345-p
IRS1 (mouse) RPAsVDGsPVsPSTN S340-p
IRS1 (rat) RPAsVDGSPVsPstN S340
S343-p
sVDGsPVsPSTNRTH
Upstream
1 51
Treatment
  • insulin
  • PTH(1-34)
IRS1 (human) sVDGsPVsPstNRTH S348-p
IRS1 (mouse) sVDGsPVsPSTNRTH S343-p
IRS1 (rat) sVDGSPVsPstNRTH S343-p
S345
DGsPVsPSTNRTHAH
1 4
IRS1 (human) DGsPVsPstNRTHAH S350-p
IRS1 (mouse) DGsPVsPSTNRTHAH S345
IRS1 (rat) DGSPVsPstNRTHAH S345-p
T346
GsPVsPSTNRTHAHR
1 5
IRS1 (human) GsPVsPstNRTHAHR T351-p
IRS1 (mouse) GsPVsPSTNRTHAHR T346
IRS1 (rat) GSPVsPstNRTHAHR T346-p
S357
HAHRHRGSSRLHPPL
2 0
IRS1 (human) HAHRHRGsARLHPPL S362-p
IRS1 (mouse) HAHRHRGSSRLHPPL S357
IRS1 (rat) HAHRHRGssRLHPPL S357-p
S358
AHRHRGSSRLHPPLN
3 0
IRS1 (human) AHRHRGsARLHPPLN A363
IRS1 (mouse) AHRHRGSSRLHPPLN S358
IRS1 (rat) AHRHRGssRLHPPLN S358-p
S367
LHPPLNHSRsIPMPS
0 2
IRS1 (human) LHPPLNHsrsIPMPA S372-p
IRS1 (mouse) LHPPLNHSRsIPMPS S367
IRS1 (rat) LHPPLNHSRsIPMPS S367
R368
HPPLNHSRsIPMPSS
0 2
IRS1 (human) HPPLNHsrsIPMPAS R373-m1
IRS1 (mouse) HPPLNHSRsIPMPSS R368
IRS1 (rat) HPPLNHSRsIPMPSS R368
S369-p
PPLNHSRsIPMPSSR
3 16
IRS1 (human) PPLNHsrsIPMPASR S374-p
IRS1 (mouse) PPLNHSRsIPMPSSR S369-p
IRS1 (rat) PPLNHSRsIPMPSSR S369-p
S378-p
PMPSSRCsPSATsPV
Upstream
0 5
Treatment
  • insulin
IRS1 (human) PMPASRCsPsATsPV S383-p
IRS1 (mouse) PMPSSRCsPSATsPV S378-p
IRS1 (rat) PMPSSRCSPSATSPV S378
S380
PSSRCsPSATsPVSL
0 1
IRS1 (human) PASRCsPsATsPVsL S385-p
IRS1 (mouse) PSSRCsPSATsPVSL S380
IRS1 (rat) PSSRCSPSATSPVSL S380
S383-p
RCsPSATsPVSLSSS
0 3
IRS1 (human) RCsPsATsPVsLSSS S388-p
IRS1 (mouse) RCsPSATsPVSLSSS S383-p
IRS1 (rat) RCSPSATSPVSLSSS S383
S386
PSATsPVSLSSSSTS
0 1
IRS1 (human) PsATsPVsLSSSSTS S391-p
IRS1 (mouse) PSATsPVSLSSSSTS S386
IRS1 (rat) PSATSPVSLSSSSTS S386
S407
DCLFPRRSsASVsGs
1 0
IRS1 (human) DCLFPRRSsAsVsGs S412
IRS1 (mouse) DCLFPRRSsASVsGs S407
IRS1 (rat) DCLFPRRssASVSGs S407-p
S408-p
CLFPRRSsASVsGsP
Upstream
Downstream
4 1
Effects on Modified Protein
  • activity, inhibited
Treatment
  • calyculin_A
  • insulin
  • sphingomyelinase
view more >
IRS1 (human) CLFPRRSsAsVsGsP S413-p
IRS1 (mouse) CLFPRRSsASVsGsP S408-p
IRS1 (rat) CLFPRRssASVSGsP S408-p
S412-p
RRSsASVsGsPSDGG
0 2
IRS1 (human) RRSsAsVsGsPSDGG S417-p
IRS1 (mouse) RRSsASVsGsPSDGG S412-p
IRS1 (rat) RRssASVSGsPsDGG S412
S414-p
SsASVsGsPSDGGFI
Upstream
2 3
Treatment
  • insulin
IRS1 (human) SsAsVsGsPSDGGFI S419-p
IRS1 (mouse) SsASVsGsPSDGGFI S414-p
IRS1 (rat) ssASVSGsPsDGGFI S414-p
S416
ASVsGsPSDGGFIss
2 0
IRS1 (human) AsVsGsPSDGGFISS S421
IRS1 (mouse) ASVsGsPSDGGFIss S416
IRS1 (rat) ASVSGsPsDGGFIss S416-p
S422-p
PSDGGFIssDEYGSS
1 2
IRS1 (human) PSDGGFISSDEYGSS S427
IRS1 (mouse) PSDGGFIssDEYGSS S422-p
IRS1 (rat) PsDGGFIssDEYGSS S422-p
S423-p
SDGGFIssDEYGSSP
Upstream
1 3
Treatment
  • insulin
IRS1 (human) SDGGFISSDEYGSSP S428
IRS1 (mouse) SDGGFIssDEYGSSP S423-p
IRS1 (rat) sDGGFIssDEYGSSP S423-p
S436
SPCDFRSSFRsVtPD
1 0
IRS1 (human) SPCDFRSsFRsVtPD S441-p
IRS1 (mouse) SPCDFRSSFRsVtPD S436
IRS1 (rat) SPCDFRSSFRSVtPD S436
S439-p
DFRSSFRsVtPDsLG
Upstream
0 3
Treatment
  • insulin
IRS1 (human) DFRSsFRsVtPDsLG S444-p
IRS1 (mouse) DFRSSFRsVtPDsLG S439-p
IRS1 (rat) DFRSSFRSVtPDSLG S439
T441-p
RSSFRsVtPDsLGHt
Upstream
1 24
Treatment
  • insulin
  • PTH(1-34)
IRS1 (human) RSsFRsVtPDsLGHt T446-p
IRS1 (mouse) RSSFRsVtPDsLGHt T441-p
IRS1 (rat) RSSFRSVtPDSLGHt T441-p
S444-p
FRsVtPDsLGHtPPA
Upstream
0 10
Treatment
  • insulin
  • LY294002
  • MK-2206
view more >
IRS1 (human) FRsVtPDsLGHtPPA S449-p
IRS1 (mouse) FRsVtPDsLGHtPPA S444-p
IRS1 (rat) FRSVtPDSLGHtPPA S444
T448-p
tPDsLGHtPPARGEE
Upstream
0 25
Treatment
  • insulin
  • LY294002
  • MK-2206
  • PTH(1-34)
view more >
IRS1 (human) tPDsLGHtPPARGEE T453-p
IRS1 (mouse) tPDsLGHtPPARGEE T448-p
IRS1 (rat) tPDSLGHtPPARGEE T448-p
S458-p
ARGEEELsNyICMGG
0 2
IRS1 (human) ARGEEELsNyICMGG S463-p
IRS1 (mouse) ARGEEELsNyICMGG S458-p
IRS1 (rat) ARGEEELSNyICMGG S458
Y460-p
GEEELsNyICMGGKG
Upstream
Downstream
2 12
Effects on Modified Protein
  • activity, induced
Treatment
  • calorie_restriction
  • insulin
  • MK-2206
view more >
IRS1 (human) GEEELsNyICMGGKG Y465-p
IRS1 (mouse) GEEELsNyICMGGKG Y460-p
IRS1 (rat) GEEELSNyICMGGKG Y460-p
Y478-p
LAAPNGHyILSRGGN
Upstream
0 4
Treatment
  • insulin
IRS1 (human) LTAPNGHyILsRGGN Y483-p
IRS1 (mouse) LAAPNGHyILSRGGN Y478-p
IRS1 (rat) LTAPNGHYILSRGGN Y478
S481
PNGHyILSRGGNGHR
0 3
IRS1 (human) PNGHyILsRGGNGHR S486-p
IRS1 (mouse) PNGHyILSRGGNGHR S481
IRS1 (rat) PNGHYILSRGGNGHR S481
I490
GGNGHRYIPGANLGT
1 2
IRS1 (human) GGNGHRCtPGtGLGt T495-p
IRS1 (mouse) GGNGHRYIPGANLGT I490
IRS1 (rat) GGNGHRYIPGATMGT I490
A493
GHRYIPGANLGTSPA
0 1
IRS1 (human) GHRCtPGtGLGtsPA T498-p
IRS1 (mouse) GHRYIPGANLGTSPA A493
IRS1 (rat) GHRYIPGATMGTsPA A493
T497
IPGANLGTSPALPGD
0 1
IRS1 (human) tPGtGLGtsPALAGD T502-p
IRS1 (mouse) IPGANLGTSPALPGD T497
IRS1 (rat) IPGATMGTsPALtGD T497
S498
PGANLGTSPALPGDE
3 1
IRS1 (human) PGtGLGtsPALAGDE S503-p
IRS1 (mouse) PGANLGTSPALPGDE S498
IRS1 (rat) PGATMGTsPALtGDE S498-p
P502
LGTSPALPGDEAAGA
1 0
IRS1 (human) LGtsPALAGDEAASA A507
IRS1 (mouse) LGTSPALPGDEAAGA P502
IRS1 (rat) MGTsPALtGDEAAGA T502-p
T520-p
DNRFRKRtHsAGtsP
0 2
IRS1 (human) DNRFRKRtHsAGtsP T525-p
IRS1 (mouse) DNRFRKRtHsAGtsP T520-p
IRS1 (rat) DNRFRKRTHsAGtsP T520
S522-p
RFRKRtHsAGtsPTI
Upstream
7 25
Treatment
  • GSK650394
  • insulin
  • LY294002
  • MK-2206
  • Torin1
view more >
IRS1 (human) RFRKRtHsAGtsPtI S527-p
IRS1 (mouse) RFRKRtHsAGtsPTI S522-p
IRS1 (rat) RFRKRTHsAGtsPTI S522-p
T525-p
KRtHsAGtsPTIsHQ
Upstream
2 5
Treatment
  • insulin
  • LY294002
  • MK-2206
view more >
IRS1 (human) KRtHsAGtsPtITHQ T530-p
IRS1 (mouse) KRtHsAGtsPTIsHQ T525-p
IRS1 (rat) KRTHsAGtsPTISHQ T525-p
S526-p
RtHsAGtsPTIsHQK
Upstream
1 19
Treatment
  • insulin
  • LY294002
  • MK-2206
view more >
IRS1 (human) RtHsAGtsPtITHQK S531-p
IRS1 (mouse) RtHsAGtsPTIsHQK S526-p
IRS1 (rat) RTHsAGtsPTISHQK S526-p
T528
HsAGtsPTIsHQKTP
0 2
IRS1 (human) HsAGtsPtITHQKTP T533-p
IRS1 (mouse) HsAGtsPTIsHQKTP T528
IRS1 (rat) HsAGtsPTISHQKTP T528
S530-p
AGtsPTIsHQKTPSQ
0 1
IRS1 (human) AGtsPtITHQKTPSQ T535
IRS1 (mouse) AGtsPTIsHQKTPSQ S530-p
IRS1 (rat) AGtsPTISHQKTPSQ S530
S570
RLPGYRHSAFVPTHs
4 5
IRS1 (human) RLPGHRHsAFVPTRs S574-p
IRS1 (mouse) RLPGYRHSAFVPTHs S570
IRS1 (rat) RLPGYRHsAFVPTHS S570-p
S577-p
SAFVPTHsYPEEGLE
Upstream
0 4
Treatment
  • insulin
  • MK-2206
IRS1 (human) sAFVPTRsYPEEGLE S581-p
IRS1 (mouse) SAFVPTHsYPEEGLE S577-p
IRS1 (rat) sAFVPTHSYPEEGLE S577
T599-p
GGHHRPDtsNLHTDD
0 23
IRS1 (human) GGHHRPDsstLHtDD S603-p
IRS1 (mouse) GGHHRPDtsNLHTDD T599-p
IRS1 (rat) GGHHRPDssNLHtDD S599-p
S600-p
GHHRPDtsNLHTDDG
0 11
IRS1 (human) GHHRPDsstLHtDDG S604-p
IRS1 (mouse) GHHRPDtsNLHTDDG S600-p
IRS1 (rat) GHHRPDssNLHtDDG S600-p
N601
HHRPDtsNLHTDDGy
0 20
IRS1 (human) HHRPDsstLHtDDGy T605-p
IRS1 (mouse) HHRPDtsNLHTDDGy N601
IRS1 (rat) HHRPDssNLHtDDGy N601
T604
PDtsNLHTDDGyMPM
0 25
IRS1 (human) PDsstLHtDDGyMPM T608-p
IRS1 (mouse) PDtsNLHTDDGyMPM T604
IRS1 (rat) PDssNLHtDDGyMPM T604-p
Y608-p
NLHTDDGyMPMsPGV
Upstream
Downstream
42 304
Effects on Biological Processes:
  • neural plasticity
Regulatory protein:
  • BLVRB (mouse)
  • CAMK2G (human)
  • IGF2BP2 (mouse)
  • ROCK1 (mouse)
view more >
Treatment
  • adiponectin
  • DEN
  • G-1
  • high_glucose
  • HM-chromanone
  • insulin
  • ovariectomy
  • palmitate
  • Panax notoginseng saponin
  • PUGNAc
  • TNF
  • wortmannin
view more >
IRS1 (human) tLHtDDGyMPMsPGV Y612-p
IRS1 (mouse) NLHTDDGyMPMsPGV Y608-p
IRS1 (rat) NLHtDDGyMPMsPGV Y608-p
S612-p
DDGyMPMsPGVAPVP
Upstream
Downstream
42 11
IRS1 (human)
S616-p
IRS1 (mouse)
S612-p
IRS1 (rat)
S612-p
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (mouse)
Putative in vivo kinases:
  • GRK2 (mouse)
Regulatory protein:
  • Akt1 (mouse)
  • SMTNL1 (human)
Treatment
  • endothelin
  • estradiol
  • high-fat diet
  • IL-4
  • IL-6
  • insulin
  • JNK_inhibitor_I
  • liothyronine
  • PD98059
  • PDGF
  • SHP099
view more >
IRS1 (human) DDGyMPMsPGVAPVP S616-p
IRS1 (mouse) DDGyMPMsPGVAPVP S612-p
IRS1 (rat) DDGyMPMsPGVAPVP S612-p
S620
PGVAPVPSNRKGNGD
0 1
IRS1 (human) PGVAPVPsGRKGsGD S624-p
IRS1 (mouse) PGVAPVPSNRKGNGD S620
IRS1 (rat) PGVAPVPSNRKGNGD S620
N625
VPSNRKGNGDyMPMs
2 55
IRS1 (human) VPsGRKGsGDyMPMs S629-p
IRS1 (mouse) VPSNRKGNGDyMPMs N625
IRS1 (rat) VPSNRKGNGDyMPMs N625
Y628-p
NRKGNGDyMPMsPKs
Upstream
Downstream
14 300
Effects on Modified Protein
  • activity, induced
Treatment
  • calorie_restriction
  • casein
  • Dendrobium officinale polysaccharide
  • glucose
  • high_glucose
  • IL-6
  • insulin
  • linoleic_acid
  • NT157
  • Pentadecanoic acid
  • rapamycin
  • TNF
view more >
IRS1 (human) GRKGsGDyMPMsPKs Y632-p
IRS1 (mouse) NRKGNGDyMPMsPKs Y628-p
IRS1 (rat) NRKGNGDyMPMsPKs Y628-p
S632-p
NGDyMPMsPKsVsAP
Upstream
Downstream
48 29
IRS1 (human)
S636-p
IRS1 (mouse)
S632-p
IRS1 (rat)
S632-p
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • neural plasticity
  • signaling pathway regulation
Kinase, in vitro:
  • mTOR (mouse)
  • ROCK2 (mouse)
Putative in vivo kinases:
  • mTOR (human)
  • ROCK1 (rat)
  • ROCK2 (mouse)
view more >
Regulatory protein:
  • Akt1 (mouse)
  • Raptor (mouse)
  • ROCK1 (mouse)
  • ROCK2 (human)
  • Sin1 (human)
view more >
Treatment
  • adiponectin
  • antibody
  • conditioned medium
  • dactolisib
  • estradiol
  • exercise
  • high-fat diet
  • IGF-1
  • insulin
  • MG132
  • minocycline
  • obesity
  • oleic_acid
  • palmitate
  • PDGF
  • PTH(1-34)
  • rapamycin
  • serum
  • serum_withdrawal
  • siRNA
  • TNF
  • Torin1
  • troglitazone
  • Y27632
view more >
IRS1 (human) sGDyMPMsPKsVSAP S636-p
IRS1 (mouse) NGDyMPMsPKsVsAP S632-p
IRS1 (rat) NGDyMPMsPKsVsAP S632-p
S635-p
yMPMsPKsVsAPQQI
Upstream
Downstream
42 4
IRS1 (human)
S639-p
IRS1 (mouse)
S635-p
IRS1 (rat)
S635-p
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • mTOR (mouse)
  • ROCK2 (mouse)
Putative in vivo kinases:
  • GRK2 (mouse)
  • mTOR (human)
  • ROCK1 (rat)
  • ROCK2 (mouse)
view more >
Regulatory protein:
  • Raptor (mouse)
  • ROCK1 (mouse)
  • ROCK2 (human)
  • Sin1 (human)
view more >
Treatment
  • adiponectin
  • dactolisib
  • endothelin
  • exercise
  • high-fat diet
  • IGF-1
  • insulin
  • isoflurane
  • MG132
  • obesity
  • palmitate
  • rapamycin
  • serum
  • serum_withdrawal
  • siRNA
  • streptozotocin
  • TNF
  • Torin1
  • troglitazone
  • Y27632
view more >
IRS1 (human) yMPMsPKsVSAPQQI S639-p
IRS1 (mouse) yMPMsPKsVsAPQQI S635-p
IRS1 (rat) yMPMsPKsVsAPQQI S635-p
S637-p
PMsPKsVsAPQQIIN
Upstream
2 1
Treatment
  • insulin
  • LY294002
IRS1 (human) PMsPKsVSAPQQIIN S641
IRS1 (mouse) PMsPKsVsAPQQIIN S637-p
IRS1 (rat) PMsPKsVsAPQQIIN S637-p
Y658
QRVDPNGYMMMsPSG
2 94
IRS1 (human) QRVDPNGyMMMsPsG Y662-p
IRS1 (mouse) QRVDPNGYMMMsPSG Y658
IRS1 (rat) QRVDPNGYMMMsPSG Y658
S662-p
PNGYMMMsPSGSCSP
Upstream
Downstream
2 7
Effects on Modified Protein
  • molecular association, regulation
Regulatory protein:
  • Akt1 (mouse)
Treatment
  • PDGF
IRS1 (human) PNGyMMMsPsGGCsP S666-p
IRS1 (mouse) PNGYMMMsPSGSCSP S662-p
IRS1 (rat) PNGYMMMsPSGSCSP S662-p
S664
GYMMMsPSGSCSPDI
0 7
IRS1 (human) GyMMMsPsGGCsPDI S668-p
IRS1 (mouse) GYMMMsPSGSCSPDI S664
IRS1 (rat) GYMMMsPSGSCSPDI S664
S668
MsPSGSCSPDIGGGS
0 3
IRS1 (human) MsPsGGCsPDIGGGP S672-p
IRS1 (mouse) MsPSGSCSPDIGGGS S668
IRS1 (rat) MsPSGSCSPDIGGGS S668
S675
SPDIGGGSSSSSSIS
0 1
IRS1 (human) PDIGGGPsSSSSSSN S680-p
IRS1 (mouse) SPDIGGGSSSSSSIS S675
IRS1 (rat) SPDIGGGSCSSSSIS S675
S689
SAAPSGSSYGKPWTN
0 1
IRS1 (human) NAVPSGTsyGKLWTN S694-p
IRS1 (mouse) SAAPSGSSYGKPWTN S689
IRS1 (rat) SAAPSGSSYGKPWTN S689
Y690
AAPSGSSYGKPWTNG
0 2
IRS1 (human) AVPSGTsyGKLWTNG Y695-p
IRS1 (mouse) AAPSGSSYGKPWTNG Y690
IRS1 (rat) AAPSGSSYGKPWTNG Y690
Y727
LLPCTGDYMNMsPVG
2 1
IRS1 (human) LLPCTGDyMNMSPVG Y732-p
IRS1 (mouse) LLPCTGDYMNMsPVG Y727
IRS1 (rat) LLPCTGDYMNMsPVG Y727
S731-p
TGDYMNMsPVGDSNT
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
Regulatory protein:
  • Akt1 (mouse)
Treatment
  • PDGF
IRS1 (human) TGDyMNMSPVGDSNT S736
IRS1 (mouse) TGDYMNMsPVGDSNT S731-p
IRS1 (rat) TGDYMNMsPVGDSNT S731-p
S761-p
KPVLSYYsLPRSFKH
0 8
IRS1 (human) KPVLSYYsLPRSFkH S766-p
IRS1 (mouse) KPVLSYYsLPRSFKH S761-p
IRS1 (rat) KPVLSYYSLPRSFKH S761
K767
YsLPRSFKHTQRPGE
0 1
IRS1 (human) YsLPRSFkHtQRPGE K772-m1
IRS1 (mouse) YsLPRSFKHTQRPGE K767
IRS1 (rat) YSLPRSFKHTQRPGE K767
K767
YsLPRSFKHTQRPGE
0 1
IRS1 (human) YsLPRSFkHtQRPGE K772-ub
IRS1 (mouse) YsLPRSFKHTQRPGE K767
IRS1 (rat) YSLPRSFKHTQRPGE K767
T769
LPRSFKHTQRPGEPE
0 1
IRS1 (human) LPRSFkHtQRPGEPE T774-p
IRS1 (mouse) LPRSFKHTQRPGEPE T769
IRS1 (rat) LPRSFKHTQRPGEPE T769
S789-p
QHLRLSSsSGRLRYT
Upstream
11 0
IRS1 (human)
S794-p
IRS1 (mouse)
S789-p
IRS1 (rat)
S789-p
Kinase, in vitro:
  • AMPKA1 (rat)
Treatment
  • acadesine
  • insulin
  • wortmannin
view more >
IRS1 (human) QHLRLStsSGRLLyA S794-p
IRS1 (mouse) QHLRLSSsSGRLRYT S789-p
IRS1 (rat) QHLRLSSsSGRLRYT S789-p
Y795
SsSGRLRYTATAEDS
0 1
IRS1 (human) tsSGRLLyAATADDS Y800-p
IRS1 (mouse) SsSGRLRYTATAEDS Y795
IRS1 (rat) SsSGRLRYTATAEDS Y795
T842
HLPRKVDTAAQTNSR
0 1
IRS1 (human) HLPRKVDtAAQTNSR T847-p
IRS1 (mouse) HLPRKVDTAAQTNSR T842
IRS1 (rat) HLPRKVDTAAQTNSR T842
T854-p
NSRLARPtRLsLGDP
0 2
IRS1 (human) NSRLARPtRLsLGDP T859-p
IRS1 (mouse) NSRLARPtRLsLGDP T854-p
IRS1 (rat) NSRLARPTRLsLGDP T854
S857-p
LARPtRLsLGDPKAS
2 4
IRS1 (human) LARPtRLsLGDPkAS S862-p
IRS1 (mouse) LARPtRLsLGDPKAS S857-p
IRS1 (rat) LARPTRLsLGDPKAS S857-p
K862
RLsLGDPKASTLPRV
0 1
IRS1 (human) RLsLGDPkASTLPRA K867-ub
IRS1 (mouse) RLsLGDPKASTLPRV K862
IRS1 (rat) RLsLGDPKASTLPRV K862
S887-p
LHPPEPKsPGEyVNI
Upstream
5 19
Treatment
  • insulin
IRS1 (human) LHPPEPKsPGEyVNI S892-p
IRS1 (mouse) LHPPEPKsPGEyVNI S887-p
IRS1 (rat) LHPPEPKsPGEyVNI S891-p
Y891-p
EPKsPGEyVNIEFGS
Upstream
Downstream
15 2
IRS1 (human)
Y896-p
IRS1 (mouse)
Y891-p
IRS1 (rat)
Y895-p
Effects on Biological Processes:
  • signaling pathway regulation
Regulatory protein:
  • RICTOR (mouse)
Treatment
  • decosahexaenoic acid
  • insulin
  • Omega-3
view more >
IRS1 (human) EPKsPGEyVNIEFGS Y896-p
IRS1 (mouse) EPKsPGEyVNIEFGS Y891-p
IRS1 (rat) EPKsPGEyVNIEFGS Y895-p
S910
YLAGPATSRSSPSVR
1 0
IRS1 (human) YLSGPVAFHSSPSVR F915
IRS1 (mouse) YLAGPATSRSSPSVR S910
IRS1 (rat) YLAGPATsRSSPSVR S914-gl
T930
HPAPREETGSEEyMN
0 1
IRS1 (human) PAPREEEtGtEEyMK T936-p
IRS1 (mouse) HPAPREETGSEEyMN T930
IRS1 (rat) HPAPREETGSEEyMN T934
S932
APREETGSEEyMNMD
0 3
IRS1 (human) PREEEtGtEEyMKMD T938-p
IRS1 (mouse) APREETGSEEyMNMD S932
IRS1 (rat) APREETGSEEyMNMD S936
Y935-p
EETGSEEyMNMDLGP
Upstream
Downstream
4 51
Effects on Modified Protein
  • activity, induced
Treatment
  • calorie_restriction
  • insulin
IRS1 (human) EEtGtEEyMKMDLGP Y941-p
IRS1 (mouse) EETGSEEyMNMDLGP Y935-p
IRS1 (rat) EETGSEEyMNMDLGP Y939-p
N978
RPTRSVPNSRGDyMT
1 0
IRS1 (human) RPTRAVPssRGDyMT S984-gl
IRS1 (mouse) RPTRSVPNSRGDyMT N978
IRS1 (rat) RPTRSVPNSRGDyMT N982
S979
PTRSVPNSRGDyMTM
1 0
IRS1 (human) PTRAVPssRGDyMTM S985-gl
IRS1 (mouse) PTRSVPNSRGDyMTM S979
IRS1 (rat) PTRSVPNSRGDyMTM S983
Y983-p
VPNSRGDyMTMQIGC
Upstream
Downstream
4 19
Effects on Modified Protein
  • activity, induced
Treatment
  • calorie_restriction
  • insulin
IRS1 (human) VPssRGDyMTMQMSC Y989-p
IRS1 (mouse) VPNSRGDyMTMQIGC Y983-p
IRS1 (rat) VPNSRGDyMTMQIGC Y987-p
S999-p
RQSYVDTsPVAPVSY
4 7
IRS1 (human) RQSYVDTsPAAPVsy S1005-p
IRS1 (mouse) RQSYVDTsPVAPVSY S999-p
IRS1 (rat) RQSYVDTsPVAPVsY S1003-p
S1005
TsPVAPVSYADMRTG
1 0
IRS1 (human) TsPAAPVsyADMRTG S1011-gl
IRS1 (mouse) TsPVAPVSYADMRTG S1005
IRS1 (rat) TsPVAPVsYADMRTG S1009-gl
Y1006
sPVAPVSYADMRTGI
0 1
IRS1 (human) sPAAPVsyADMRTGI Y1012-p
IRS1 (mouse) sPVAPVSYADMRTGI Y1006
IRS1 (rat) sPVAPVsYADMRTGI Y1010
S1019
GIAAEKASLPRPTGA
0 1
IRS1 (human) GIAAEEVsLPRATMA S1025-p
IRS1 (mouse) GIAAEKASLPRPTGA S1019
IRS1 (rat) GIAAEKVSLPRTTGA S1023
S1032
GAAPPPSSTASSSAS
2 1
IRS1 (human) MAAASSSSAAsAsPT S1038
IRS1 (mouse) GAAPPPSSTASSSAS S1032
IRS1 (rat) GAAPPPSsTASAsAS S1036-gl
S1035
PPPSSTASSSASVTP
1 1
IRS1 (human) ASSSSAAsAsPTGPQ S1041-p
IRS1 (mouse) PPPSSTASSSASVTP S1035
IRS1 (rat) PPPSsTASAsASVtP S1039
S1037
PSSTASSSASVTPQG
1 0
IRS1 (human) SSSAAsASPTGPQGA S1043
IRS1 (mouse) PSSTASSSASVTPQG S1037
IRS1 (rat) PSsTASAsASVtPQG S1041-gl
S1037
PSSTASSSASVTPQG
1 0
IRS1 (human) SSSAAsAsPTGPQGA S1043-p
IRS1 (mouse) PSSTASSSASVTPQG S1037
IRS1 (rat) PSsTASASASVtPQG S1041
T1041
ASSSASVTPQGATAE
1 1
IRS1 (human) AAsAsPTGPQGAAEL G1046
IRS1 (mouse) ASSSASVTPQGATAE T1041
IRS1 (rat) ASAsASVtPQGAAEQ T1045-p
S1053
TAEQATHSSLLGGPQ
0 1
IRS1 (human) AAELAAHssLLGGPQ S1057-p
IRS1 (mouse) TAEQATHSSLLGGPQ S1053
IRS1 (rat) AAEQAAHSSLLGGPQ S1056
S1054
AEQATHSSLLGGPQG
0 1
IRS1 (human) AELAAHssLLGGPQG S1058-p
IRS1 (mouse) AEQATHSSLLGGPQG S1054
IRS1 (rat) AEQAAHSSLLGGPQG S1057
S1066
PQGPGGMSAFTRVNL
0 1
IRS1 (human) PQGPGGMsAFTRVNL S1070-p
IRS1 (mouse) PQGPGGMSAFTRVNL S1066
IRS1 (rat) PQGPGGMSAFTRVNL S1069
S1074-p
AFTRVNLsPNHNQSA
3 32
IRS1 (human) AFTRVNLsPNRNQsA S1078-p
IRS1 (mouse) AFTRVNLsPNHNQSA S1074-p
IRS1 (rat) AFTRVNLsPNHNQSA S1077-p
S1080
LsPNHNQSAKVIRAD
0 1
IRS1 (human) LsPNRNQsAKVIRAD S1084-p
IRS1 (mouse) LsPNHNQSAKVIRAD S1080
IRS1 (rat) LsPNHNQSAKVIRAD S1083
S1096-p
QGCRRRHssEtFSAP
Upstream
1 100
Treatment
  • insulin
IRS1 (human) QGCRRRHssEtFsSt S1100-p
IRS1 (mouse) QGCRRRHssEtFSAP S1096-p
IRS1 (rat) QGCRRRHssEtFSAP S1099-p
S1097-p
GCRRRHssEtFSAPt
Upstream
Downstream
16 161
IRS1 (mouse)
S1097-p
IRS1 (rat)
S1100-p
Effects on Modified Protein
  • activity, inhibited
Putative in vivo kinases:
  • p70S6K (human)
  • PKCT (mouse)
Treatment
  • amino_acids
  • arachidonic_acid
  • bisindolylmaleimide
  • IGF-1
  • insulin
  • LY294002
  • oleic_acid
  • phorbol_ester
  • PTH(1-34)
  • rapamycin
  • TNF
  • U0126
  • wortmannin
view more >
IRS1 (human) GCRRRHssEtFsStP S1101-p
IRS1 (mouse) GCRRRHssEtFSAPt S1097-p
IRS1 (rat) GCRRRHssEtFSAPt S1100-p
T1099-p
RRRHssEtFSAPtRA
2 8
IRS1 (human) RRRHssEtFsStPsA T1103-p
IRS1 (mouse) RRRHssEtFSAPtRA T1099-p
IRS1 (rat) RRRHssEtFSAPtRA T1102-p
S1101
RHssEtFSAPtRAGN
0 1
IRS1 (human) RHssEtFsStPsAtR S1105-p
IRS1 (mouse) RHssEtFSAPtRAGN S1101
IRS1 (rat) RHssEtFSAPtRAAN S1104
P1103
ssEtFSAPtRAGNTV
0 3
IRS1 (human) ssEtFsStPsAtRVG T1107-p
IRS1 (mouse) ssEtFSAPtRAGNTV P1103
IRS1 (rat) ssEtFSAPtRAANTV P1106
-
gap
0 1
IRS1 (human) EtFsStPsAtRVGNt S1109-p
IRS1 (mouse) gap -
IRS1 (rat) gap -
T1104-p
sEtFSAPtRAGNTVP
2 4
IRS1 (human) FsStPsAtRVGNtVP T1111-p
IRS1 (mouse) sEtFSAPtRAGNTVP T1104-p
IRS1 (rat) sEtFSAPtRAANTVS T1107-p
T1109
APtRAGNTVPFGAGA
0 1
IRS1 (human) sAtRVGNtVPFGAGA T1116-p
IRS1 (mouse) APtRAGNTVPFGAGA T1109
IRS1 (rat) APtRAANTVSFGAGA T1112
S1136-p
SEDVKRHssAsFENV
3 6
IRS1 (human) SEDVKRHssAsFENV S1142-p
IRS1 (mouse) SEDVKRHssAsFENV S1136-p
IRS1 (rat) SEDVKRHsSASFENV S1135-p
S1137-p
EDVKRHssAsFENVW
Upstream
0 7
Treatment
  • insulin
  • LY294002
  • PTH(1-34)
view more >
IRS1 (human) EDVKRHssAsFENVW S1143-p
IRS1 (mouse) EDVKRHssAsFENVW S1137-p
IRS1 (rat) EDVKRHsSASFENVW S1136
S1139-p
VKRHssAsFENVWLR
1 9
IRS1 (human) VKRHssAsFENVWLR S1145-p
IRS1 (mouse) VKRHssAsFENVWLR S1139-p
IRS1 (rat) VKRHsSASFENVWLR S1138
S1170-p
AAGGLEKsLNyIDLD
Upstream
0 2
Treatment
  • insulin
  • MK-2206
IRS1 (human) AAGGLENGLNyIDLD G1176
IRS1 (mouse) AAGGLEKsLNyIDLD S1170-p
IRS1 (rat) AAGGLEKSLNyIDLD S1169
Y1173-p
GLEKsLNyIDLDLAK
Upstream
5 27
Treatment
  • insulin
IRS1 (human) GLENGLNyIDLDLVk Y1179-p
IRS1 (mouse) GLEKsLNyIDLDLAK Y1173-p
IRS1 (rat) GLEKSLNyIDLDLVK Y1172-p
S1183
LDLAKEHSQDCPSQQ
1 0
IRS1 (human) LDLVkDFkQCPQECT K1189-ub
IRS1 (mouse) LDLAKEHSQDCPSQQ S1183
IRS1 (rat) LDLVKDVKQHPQDCP K1182
K1180
yIDLDLAKEHSQDCP
1 0
IRS1 (human) yIDLDLVkDFkQCPQ K1186-ub
IRS1 (mouse) yIDLDLAKEHSQDCP K1180
IRS1 (rat) yIDLDLVKDVKQHPQ K1179
S1209-p
LGSNEGNsPRRssED
0 2
IRS1 (human) LGSGESSSTRRssED S1218
IRS1 (mouse) LGSNEGNsPRRssED S1209-p
IRS1 (rat) LGSNEGSSPRRssED S1211
S1213-p
EGNsPRRssEDLsNy
2 6
IRS1 (human) ESSSTRRssEDLSAY S1222-p
IRS1 (mouse) EGNsPRRssEDLsNy S1213-p
IRS1 (rat) EGSSPRRssEDLSTy S1215-p
S1214-p
GNsPRRssEDLsNyA
Upstream
3 17
Treatment
  • PTH(1-34)
IRS1 (human) SSSTRRssEDLSAYA S1223-p
IRS1 (mouse) GNsPRRssEDLsNyA S1214-p
IRS1 (rat) GSSPRRssEDLSTyA S1216-p
S1218-p
RRssEDLsNyASISF
0 2
IRS1 (human) RRssEDLSAYASISF S1227
IRS1 (mouse) RRssEDLsNyASISF S1218-p
IRS1 (rat) RRssEDLSTyASINF S1220
Y1220-p
ssEDLsNyASISFQK
Upstream
3 2
IRS1 (human)
Y1229-p
IRS1 (mouse)
Y1220-p
IRS1 (rat)
Y1222-p
Treatment
  • CNB-001
  • insulin
  • palmitate
view more >
IRS1 (human) ssEDLSAYASISFQK Y1229
IRS1 (mouse) ssEDLsNyASISFQK Y1220-p
IRS1 (rat) ssEDLSTyASINFQK Y1222-p
S410
FPRRSsASVsGsPSD
0 1
IRS1 (human) FPRRSsAsVsGsPSD S415-p
IRS1 (mouse) FPRRSsASVsGsPSD S410
IRS1 (rat) FPRRssASVSGsPsD S410
S788
HQHLRLSSsSGRLRY
0 1
IRS1 (human) HQHLRLStsSGRLLy T793-p
IRS1 (mouse) HQHLRLSSsSGRLRY S788
IRS1 (rat) HQHLRLSSsSGRLRY S788