Other Species / Isoforms
  MEKK2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S26-p
KASRPALsLQETRKA
0 8
MEKK2 (human) KASRPALsLQETRKA S26-p
MEKK2 (mouse) KASRPALSLQETRKA S26
MEKK2 (rat) KASRPALSLQETRKA S26
S109-p
AVELLDRsIHMKSLK
0 1
MEKK2 (human) AVELLDRsIHMKSLK S109-p
MEKK2 (mouse) AVELLDRSIHMKSLK S109
MEKK2 (rat) AVELLDRSIHMKSLK S109
S153-p
AERKKRLsIIGPtsR
Upstream
Downstream
3 62
Effects on Modified Protein
  • protein stabilization
  • ubiquitination
Regulatory protein:
  • VMD2L3 (human)
Treatment
  • BI2536
  • MLN8054
MEKK2 (human) AERKKRLsIIGPtsR S153-p
MEKK2 (mouse) AERKKRLsVVGPPNR S153-p
MEKK2 (rat) AERKKRLsVVGPPNR S153-p
T158-p
RLsIIGPtsRDRssP
0 1
MEKK2 (human) RLsIIGPtsRDRssP T158-p
MEKK2 (mouse) RLsVVGPPNRDRssP P158
MEKK2 (rat) RLsVVGPPNRDRssP P158
S159-p
LsIIGPtsRDRssPP
Upstream
0 3
Treatment
  • MG132_withdrawal
MEKK2 (human) LsIIGPtsRDRssPP S159-p
MEKK2 (mouse) LsVVGPPNRDRssPP N159
MEKK2 (rat) LsVVGPPNRDRssPP N159
S163-p
GPtsRDRssPPPGyI
0 16
MEKK2 (human) GPtsRDRssPPPGyI S163-p
MEKK2 (mouse) GPPNRDRssPPPGYI S163-p
MEKK2 (rat) GPPNRDRssPPPGYI S163-p
S164-p
PtsRDRssPPPGyIP
Upstream
1 33
Treatment
  • metastatic potential
MEKK2 (human) PtsRDRssPPPGyIP S164-p
MEKK2 (mouse) PPNRDRssPPPGYIP S164-p
MEKK2 (rat) PPNRDRssPPPGYIP S164-p
Y169-p
RssPPPGyIPDELHQ
0 1
MEKK2 (human) RssPPPGyIPDELHQ Y169-p
MEKK2 (mouse) RssPPPGYIPDILHQ Y169
MEKK2 (rat) RssPPPGYIPDELHQ Y169
S232
DGESYPKSRMPRAQs
0 1
MEKK2 (human) DGESYPKSRMPRAQs S232
MEKK2 (mouse) DGESYPKsRMPRAQs S232-p
MEKK2 (rat) DGESYPKSRMPRAQs S232
S239-p
SRMPRAQsyPDNHQE
Upstream
1 284
Treatment
  • ischemia
MEKK2 (human) SRMPRAQsyPDNHQE S239-p
MEKK2 (mouse) sRMPRAQsyPDNHQE S239-p
MEKK2 (rat) SRMPRAQsYPDNHQE S239-p
Y240-p
RMPRAQsyPDNHQEF
0 22
MEKK2 (human) RMPRAQsyPDNHQEF Y240-p
MEKK2 (mouse) RMPRAQsyPDNHQEF Y240-p
MEKK2 (rat) RMPRAQsYPDNHQEF Y240
S248-p
PDNHQEFsDyDNPIF
0 19
MEKK2 (human) PDNHQEFsDyDNPIF S248-p
MEKK2 (mouse) PDNHQEFtDYDNPIF T248-p
MEKK2 (rat) PDNHQEFSDYDNPIF S248
Y250-p
NHQEFsDyDNPIFEk
0 109
MEKK2 (human) NHQEFsDyDNPIFEk Y250-p
MEKK2 (mouse) NHQEFtDYDNPIFEK Y250
MEKK2 (rat) NHQEFSDYDNPIFEK Y250
K257-ub
yDNPIFEkFGkGGtY
0 1
MEKK2 (human) yDNPIFEkFGkGGtY K257-ub
MEKK2 (mouse) YDNPIFEKFGKGGtY K257
MEKK2 (rat) YDNPIFEKFGKGGTY K257
K260-me
PIFEkFGkGGtYPRR
Upstream
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • signaling pathway regulation
Treatment
  • siRNA
MEKK2 (human) PIFEkFGkGGtYPRR K260-me
MEKK2 (mouse) PIFEKFGKGGtYPRR K260
MEKK2 (rat) PIFEKFGKGGTYPRR K260
K260-m1
PIFEkFGkGGtYPRR
0 1
MEKK2 (human) PIFEkFGkGGtYPRR K260-m1
MEKK2 (mouse) PIFEKFGKGGtYPRR K260
MEKK2 (rat) PIFEKFGKGGTYPRR K260
K260-m3
PIFEkFGkGGtYPRR
1 0
MEKK2 (human) PIFEkFGkGGtYPRR K260-m3
MEKK2 (mouse) PIFEKFGKGGtYPRR K260
MEKK2 (rat) PIFEKFGKGGTYPRR K260
T263-p
EkFGkGGtYPRRYHV
0 4
MEKK2 (human) EkFGkGGtYPRRYHV T263-p
MEKK2 (mouse) EKFGKGGtYPRRYHV T263-p
MEKK2 (rat) EKFGKGGTYPRRYHV T263
T283-p
EYNDGRKtFPRARRt
1 5
MEKK2 (human) EYNDGRKtFPRARRt T283-p
MEKK2 (mouse) EYNDGRKtFPRARRT T283-p
MEKK2 (rat) EYNDGRKTFPRARRT T283
T290-p
tFPRARRtQGTSLRs
0 1
MEKK2 (human) tFPRARRtQGTSLRs T290-p
MEKK2 (mouse) tFPRARRTQGTSFRS T290
MEKK2 (rat) TFPRARRTQGTSFRS T290
S297-p
tQGTSLRsPVsFsPT
0 3
MEKK2 (human) tQGTSLRsPVsFsPT S297-p
MEKK2 (mouse) TQGTSFRSPVSFSPT S297
MEKK2 (rat) TQGTSFRSPVSFSPT S297
S300-p
TSLRsPVsFsPTDHS
0 1
MEKK2 (human) TSLRsPVsFsPTDHS S300-p
MEKK2 (mouse) TSFRSPVSFSPTDHS S300
MEKK2 (rat) TSFRSPVSFSPTDHS S300
S302-p
LRsPVsFsPTDHSLS
0 2
MEKK2 (human) LRsPVsFsPTDHSLS S302-p
MEKK2 (mouse) FRSPVSFSPTDHSLS S302
MEKK2 (rat) FRSPVSFSPTDHSLS S302
T310
PTDHSLSTssGssIF
0 1
MEKK2 (human) PTDHSLSTssGssIF T310
MEKK2 (mouse) PTDHSLStSSGSSVF T310-p
MEKK2 (rat) PTDHSLSTSSGSSIF T310
S311-p
TDHSLSTssGssIFT
0 1
MEKK2 (human) TDHSLSTssGssIFT S311-p
MEKK2 (mouse) TDHSLStSSGSSVFT S311
MEKK2 (rat) TDHSLSTSSGSSIFT S311
S312-p
DHSLSTssGssIFTP
0 1
MEKK2 (human) DHSLSTssGssIFTP S312-p
MEKK2 (mouse) DHSLStSSGSSVFTP S312
MEKK2 (rat) DHSLSTSSGSSIFTP S312
S314-p
SLSTssGssIFTPEY
0 1
MEKK2 (human) SLSTssGssIFTPEY S314-p
MEKK2 (mouse) SLStSSGSSVFTPEY S314
MEKK2 (rat) SLSTSSGSSIFTPEY S314
S315-p
LSTssGssIFTPEYD
0 1
MEKK2 (human) LSTssGssIFTPEYD S315-p
MEKK2 (mouse) LStSSGSSVFTPEYD S315
MEKK2 (rat) LSTSSGSSIFTPEYE S315
S331-p
SRIRRRGsDIDNPtL
Upstream
1 47
Treatment
  • LRRK2-IN-1
  • MG132_withdrawal
MEKK2 (human) SRIRRRGsDIDNPtL S331-p
MEKK2 (mouse) SRIRRRGsDIDNPtL S331-p
MEKK2 (rat) SRIRRRGsDIDNPTL S331-p
T337-p
GsDIDNPtLTVMDIs
0 6
MEKK2 (human) GsDIDNPtLTVMDIs T337-p
MEKK2 (mouse) GsDIDNPtLTVtDIs T337-p
MEKK2 (rat) GsDIDNPTLTVTDIS T337
M341
DNPtLTVMDIsPPsR
0 2
MEKK2 (human) DNPtLTVMDIsPPsR M341
MEKK2 (mouse) DNPtLTVtDIsPPsR T341-p
MEKK2 (rat) DNPTLTVTDISPPSR T341
S344-p
tLTVMDIsPPsRsPR
0 19
MEKK2 (human) tLTVMDIsPPsRsPR S344-p
MEKK2 (mouse) tLTVtDIsPPsRsPR S344-p
MEKK2 (rat) TLTVTDISPPSRSPR S344
S347-p
VMDIsPPsRsPRAPT
0 4
MEKK2 (human) VMDIsPPsRsPRAPT S347-p
MEKK2 (mouse) VtDIsPPsRsPRAPT S347-p
MEKK2 (rat) VTDISPPSRSPRAPT S347
S349-p
DIsPPsRsPRAPTNW
0 7
MEKK2 (human) DIsPPsRsPRAPTNW S349-p
MEKK2 (mouse) DIsPPsRsPRAPTNW S349-p
MEKK2 (rat) DISPPSRSPRAPTNW S349
K360-ub
PTNWRLGkLLGQGAF
0 2
MEKK2 (human) PTNWRLGkLLGQGAF K360-ub
MEKK2 (mouse) PTNWRLGKLLGQGAF K360
MEKK2 (rat) PTNWRLGKLLGQGAF K360
K385-ub
TGRELAVkQVQFDPD
0 2
MEKK2 (human) TGRELAVkQVQFDPD K385-ub
MEKK2 (mouse) TGRELAVKQVQFNPE K385
MEKK2 (rat) TGRELAVKQVQFNPD K385
K411-ub
ECEIQLLkNLLHERI
0 1
MEKK2 (human) ECEIQLLkNLLHERI K411-ub
MEKK2 (mouse) ECEIQLLKNLLHERI K411
MEKK2 (rat) ECEIQLLKNLLHERI K411
T432-p
LRDPQEKtLSIFMEY
0 2
MEKK2 (human) LRDPQEKtLSIFMEY T432-p
MEKK2 (mouse) LRDPQEKTLSIFMEL T432
MEKK2 (rat) LRDPQEKTLSIFMEY T432
K450-ub
GSIKDQLkAYGALTE
0 1
MEKK2 (human) GSIKDQLkAYGALTE K450-ub
MEKK2 (mouse) GSIKDQLKAYGALTE K450
MEKK2 (rat) GSIKDQLKAYGALTE K450
Y463
TENVTRKYTRQILEG
0 1
MEKK2 (human) TENVTRKYTRQILEG Y463
MEKK2 (mouse) TENVTRKYTRQILEG Y463
MEKK2 (rat) TENVTRKyTRQILEG Y463-p
S493-p
GANILRDsTGNVkLG
0 1
MEKK2 (human) GANILRDsTGNVkLG S493-p
MEKK2 (mouse) GANILRDSTGNIKLG S493
MEKK2 (rat) GANILRDSTGNIKLG S493
K498-ub
RDsTGNVkLGDFGAs
0 1
MEKK2 (human) RDsTGNVkLGDFGAs K498-ub
MEKK2 (mouse) RDSTGNIKLGDFGAS K498
MEKK2 (rat) RDSTGNIKLGDFGAS K498
S505-p
kLGDFGAsKRLQTIC
0 2
MEKK2 (human) kLGDFGAsKRLQTIC S505-p
MEKK2 (mouse) KLGDFGASKRLQTIC S505
MEKK2 (rat) KLGDFGASKRLQTIC S505
S514-p
RLQTICLsGtGMKsV
Upstream
0 5
Treatment
  • ischemia
MEKK2 (human) RLQTICLsGtGMKsV S514-p
MEKK2 (mouse) RLQTICLsGtGMKsV S514-p
MEKK2 (rat) RLQTICLSGTGMKSV S514
T516-p
QTICLsGtGMKsVtG
0 2
MEKK2 (human) QTICLsGtGMKsVtG T516-p
MEKK2 (mouse) QTICLsGtGMKsVTG T516-p
MEKK2 (rat) QTICLSGTGMKSVTG T516
S520-p
LsGtGMKsVtGtPYW
Upstream
Downstream
2 3
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • transcription, altered
Treatment
  • anisomycin
  • CpG-1668
  • EGF
  • IL-1b
  • LPS
  • LTA
  • nocodazole
  • peptidoglycan
  • sorbitol
  • TNF
  • UV
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MEKK2 (human) LsGtGMKsVtGtPYW S520-p
MEKK2 (mouse) LsGtGMKsVTGTPYW S520-p
MEKK2 (rat) LSGTGMKSVTGTPYW S520
T522-p
GtGMKsVtGtPYWMS
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • transcription, altered
MEKK2 (human) GtGMKsVtGtPYWMS T522-p
MEKK2 (mouse) GtGMKsVTGTPYWMS T522
MEKK2 (rat) GTGMKSVTGTPYWMS T522
T524-p
GMKsVtGtPYWMSPE
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • transcription, altered
MEKK2 (human) GMKsVtGtPYWMSPE T524-p
MEKK2 (mouse) GMKsVTGTPYWMSPE T524
MEKK2 (rat) GMKSVTGTPYWMSPE T524
K581-ub
ATQPTNPkLPPHVSD
0 1
MEKK2 (human) ATQPTNPkLPPHVSD K581-ub
MEKK2 (mouse) ATQPTNPKLPPHVSD K581
MEKK2 (rat) ATQPTNPKLPPHVSD K581
K602-ub
KRIFVEAkLRPSADE
0 6
MEKK2 (human) KRIFVEAkLRPSADE K602-ub
MEKK2 (mouse) KRIFVEAkLRPSAEE K602-ub
MEKK2 (rat) KRIFVEAKLRPSAEE K602