Other Species / Isoforms
  TBK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K30-ub
VFRGRHKkTGDLFAI
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • phosphorylation
  • ubiquitination
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, induced
TBK1 (human) VFRGRHKkTGDLFAI K30-ub
TBK1 (mouse) VFRGRHKKTGDLYAV K30
TBK1 (rat) VFRGRHKKTGDLYAV K30
K30
VFRGRHKKTGDLFAI
1 1
TBK1 (human) VFRGRHKKTGDLFAI K30
TBK1 (mouse) VFRGRHKkTGDLYAV K30-ac
TBK1 (rat) VFRGRHKKTGDLYAV K30
K38
TGDLFAIKVFNNISF
0 1
TBK1 (human) TGDLFAIKVFNNISF K38
TBK1 (mouse) TGDLYAVkVFNNISF K38-ub
TBK1 (rat) TGDLYAVKVFNNISF K38
K60-ub
MREFEVLkKLNHkNI
0 1
TBK1 (human) MREFEVLkKLNHkNI K60-ub
TBK1 (mouse) MREFEVLKKLNHKNI K60
TBK1 (rat) MREFEVLKKLNHKNI K60
K65-ub
VLkKLNHkNIVkLFA
0 1
TBK1 (human) VLkKLNHkNIVkLFA K65-ub
TBK1 (mouse) VLKKLNHKNIVKLFA K65
TBK1 (rat) VLKKLNHKNIVKLFA K65
K69-ub
LNHkNIVkLFAIEEE
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, induced
TBK1 (human) LNHkNIVkLFAIEEE K69-ub
TBK1 (mouse) LNHKNIVKLFAIEEE K69
TBK1 (rat) LNHKNIVKLFAIEEE K69
S151-p
VIGEDGQsVykLTDF
0 1
TBK1 (human) VIGEDGQsVykLTDF S151-p
TBK1 (mouse) VIGEDGQSVYkLTDF S151
TBK1 (rat) VIGEDGQSVyKLTDF S151
Y153-p
GEDGQsVykLTDFGA
1 4
TBK1 (human) GEDGQsVykLTDFGA Y153-p
TBK1 (mouse) GEDGQSVYkLTDFGA Y153
TBK1 (rat) GEDGQSVyKLTDFGA Y153-p
K154-ub
EDGQsVykLTDFGAA
Downstream
1 6
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, induced
TBK1 (human) EDGQsVykLTDFGAA K154-ub
TBK1 (mouse) EDGQSVYKLTDFGAA K154
TBK1 (rat) EDGQSVyKLTDFGAA K154
K154
EDGQsVyKLTDFGAA
1 1
TBK1 (human) EDGQsVyKLTDFGAA K154
TBK1 (mouse) EDGQSVYkLTDFGAA K154-ac
TBK1 (rat) EDGQSVyKLTDFGAA K154
S172-p
EDDEQFVsLyGTEEy
Upstream
Downstream
53 52
TBK1 (human)
S172-p
TBK1 (mouse)
S172-p
TBK1 (rat)
S172-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • phosphorylation
Effects on Biological Processes:
  • DNA repair, induced
  • autophagy, induced
  • cell growth, induced
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • TBK1 (human)
Putative in vivo kinases:
  • TBK1 (human)
Regulatory protein:
  • Akt1 (human)
  • Akt2 (human)
  • Akt3 (human)
  • ATG13 (human)
  • cGAS (human)
  • DDX58 (human)
  • EGFR (human)
  • ENPP1 (human)
  • GSK3B (human)
  • HER2 (human)
  • HER3 (human)
  • HER4 (human)
  • MST1 (human)
  • optineurin (human)
  • RALB (human)
  • RB1CC1 (human)
  • Snail1 (human)
  • Snail2 (human)
  • Src iso1 (mouse)
  • STING (human)
  • TBK1 (human)
  • TFG (human)
  • TLR3 (human)
  • TRAF6 (mouse)
  • TREX1 (human)
  • UBL4A (human)
  • ULK1 (human)
  • ULK2 (human)
Treatment
  • bafilomycin_A
  • baicalein
  • BX795
  • C-170
  • camptothecin
  • cGAMP
  • cGMP_analog
  • depolarization
  • dexamethasone
  • doxycycline
  • dsDNA
  • EGF
  • H-151
  • HBSS
  • hydroxyurea
  • hypoxia
  • Icotinib
  • IL-17A
  • insulin
  • ionizing_radiation
  • lapatinib
  • Lipofectamine
  • lncRNAs
  • LPS
  • MK-2206
  • MMS
  • MRT67307
  • oligomycin
  • poly(dA:dT)
  • poly(I-C)
  • RO-3306
  • saracatinib
  • serum
  • sotrastaurin
  • starvation
  • U0126
  • UVC
  • virus infection
  • WZ4002
TBK1 (human) EDDEQFVsLyGTEEy S172-p
TBK1 (mouse) EDDEQFVsLYGTEEy S172-p
TBK1 (rat) EDDEQFVSLYGTEEY S172
Y174-p
DEQFVsLyGTEEyLH
1 4
TBK1 (human) DEQFVsLyGTEEyLH Y174-p
TBK1 (mouse) DEQFVsLYGTEEyLH Y174
TBK1 (rat) DEQFVSLYGTEEYLH Y174
Y179-p
sLyGTEEyLHPDMYE
Upstream
Downstream
2 5
Effects on Modified Protein
  • phosphorylation
Putative in vivo kinases:
  • Src iso1 (mouse)
Treatment
  • LPS
  • poly(I-C)
  • saracatinib
  • virus infection
TBK1 (human) sLyGTEEyLHPDMYE Y179-p
TBK1 (mouse) sLYGTEEyLHPDMYE Y179-p
TBK1 (rat) SLYGTEEYLHPDMYE Y179
K231-ub
FEGPRRNkEVMYkII
0 1
TBK1 (human) FEGPRRNkEVMYkII K231-ub
TBK1 (mouse) FEGPRRNKEVMYkII K231
TBK1 (rat) FEGPRRNKEVMYKII K231
K236
RNkEVMYKIITGkPS
1 1
TBK1 (human) RNkEVMYKIITGkPS K236
TBK1 (mouse) RNKEVMYkIITGkPS K236-ac
TBK1 (rat) RNKEVMYKIITGKPS K236
K236-ub
RNkEVMYkIITGkPS
0 1
TBK1 (human) RNkEVMYkIITGkPS K236-ub
TBK1 (mouse) RNKEVMYKIITGkPS K236
TBK1 (rat) RNKEVMYKIITGKPS K236
K241-ub
MYkIITGkPSGAIsG
0 4
TBK1 (human) MYkIITGkPSGAIsG K241-ub
TBK1 (mouse) MYkIITGKPSGAISG K241
TBK1 (rat) MYKIITGKPSGAISG K241
K241
MYkIITGKPSGAIsG
1 1
TBK1 (human) MYkIITGKPSGAIsG K241
TBK1 (mouse) MYkIITGkPSGAISG K241-ac
TBK1 (rat) MYKIITGKPSGAISG K241
S247-p
GkPSGAIsGVQkAEN
0 1
TBK1 (human) GkPSGAIsGVQkAEN S247-p
TBK1 (mouse) GkPSGAISGVQkAEN S247
TBK1 (rat) GKPSGAISGVQKAEN S247
K251
GAIsGVQKAENGPID
1 1
TBK1 (human) GAIsGVQKAENGPID K251
TBK1 (mouse) GAISGVQkAENGPID K251-ac
TBK1 (rat) GAISGVQKAENGPID K251
K251-ub
GAIsGVQkAENGPID
0 2
TBK1 (human) GAIsGVQkAENGPID K251-ub
TBK1 (mouse) GAISGVQKAENGPID K251
TBK1 (rat) GAISGVQKAENGPID K251
T278-p
RGLQVLLtPVLANIL
0 1
TBK1 (human) RGLQVLLtPVLANIL T278-p
TBK1 (mouse) QGLQALLTPVLANIL T278
TBK1 (rat) QGLQALLTPVLANIL T278
K291-ub
ILEADQEkCWGFDQF
0 1
TBK1 (human) ILEADQEkCWGFDQF K291-ub
TBK1 (mouse) ILEADQEKCWGFDQF K291
TBK1 (rat) ILEADQEKCWGFDQF K291
Y325-p
QMTAHKIyIHSYNTA
1 1
TBK1 (human) QMTAHKIyIHSYNTA Y325-p
TBK1 (mouse) HMTAHKIYIHSYNTA Y325
TBK1 (rat) HMTALKIYIHSYNTA Y325
Y340-p
TIFHELVyKQTkIIS
1 1
TBK1 (human) TIFHELVyKQTkIIS Y340-p
TBK1 (mouse) AVFHELVYKQTKIVS Y340
TBK1 (rat) AVFHELVYKQTKIIS Y340
K344-ub
ELVyKQTkIISSNQE
0 1
TBK1 (human) ELVyKQTkIISSNQE K344-ub
TBK1 (mouse) ELVYKQTKIVSSNQE K344
TBK1 (rat) ELVYKQTKIISSNQE K344
Y354-p
SSNQELIyEGRRLVL
Upstream
Downstream
1 3
Effects on Modified Protein
  • enzymatic activity, inhibited
  • protein conformation
Putative in vivo kinases:
  • FGR (human)
  • Hck (human)
  • Lck (human)
TBK1 (human) SSNQELIyEGRRLVL Y354-p
TBK1 (mouse) SSNQELIYEGRRLVL Y354
TBK1 (rat) SSNQELIYEGRRLVL Y354
K372-ub
RLAQHFPkTTEENPI
Upstream
Downstream
2 3
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • TRAF3IP3 (human)
TBK1 (human) RLAQHFPkTTEENPI K372-ub
TBK1 (mouse) RLAQHFPKTTEENPI K372
TBK1 (rat) RLAQHFPKTTEENPI K372
Y394-p
LNTIGLIyEkISLPk
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • protein conformation
Putative in vivo kinases:
  • FGR (human)
  • Hck (human)
  • Lck (human)
TBK1 (human) LNTIGLIyEkISLPk Y394-p
TBK1 (mouse) LNTVGLRYEKISLPK Y394
TBK1 (rat) LNSIGLRYEKISLPK Y394
K396-ub
TIGLIyEkISLPkVH
0 4
TBK1 (human) TIGLIyEkISLPkVH K396-ub
TBK1 (mouse) TVGLRYEKISLPKIH K396
TBK1 (rat) SIGLRYEKISLPKIH K396
K401-ub
yEkISLPkVHPRYDL
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • phosphorylation
  • ubiquitination
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, induced
TBK1 (human) yEkISLPkVHPRYDL K401-ub
TBK1 (mouse) YEKISLPKIHPRYDL K401
TBK1 (rat) YEKISLPKIHPRYDL K401
K416-ub
DGDASMAkAITGVVC
0 1
TBK1 (human) DGDASMAkAITGVVC K416-ub
TBK1 (mouse) DGDASMAKAVTGVVC K416
TBK1 (rat) DGDASMAKAVTGVVC K416
Y435-p
IASTLLLyQELMRKG
1 1
TBK1 (human) IASTLLLyQELMRKG Y435-p
TBK1 (mouse) TASTLLLYQELMRKG Y435
TBK1 (rat) TAGTLLLYQELMRKG Y435
K484-ub
KTVKVYEkLMKINLE
0 2
TBK1 (human) KTVKVYEkLMKINLE K484-ub
TBK1 (mouse) KTVKVYEKLMKVNLE K484
TBK1 (rat) KTVKVYEKLMKVSLD K484
S499
AAELGEISDIHtkLL
0 1
TBK1 (human) AAELGEISDIHtkLL S499
TBK1 (mouse) AAELGEIsDIHTKLL S499-p
TBK1 (rat) AAELGEISDIHTKLL S499
T503-p
GEISDIHtkLLRLSS
0 1
TBK1 (human) GEISDIHtkLLRLSS T503-p
TBK1 (mouse) GEIsDIHTKLLRLSS T503
TBK1 (rat) GEISDIHTKLLRLSS T503
K504-ub
EISDIHtkLLRLSSs
0 4
TBK1 (human) EISDIHtkLLRLSSs K504-ub
TBK1 (mouse) EIsDIHTKLLRLSSS K504
TBK1 (rat) EISDIHTKLLRLSSS K504
S511-p
kLLRLSSsQGTIETS
0 1
TBK1 (human) kLLRLSSsQGTIETS S511-p
TBK1 (mouse) KLLRLSSSQGTIESS S511
TBK1 (rat) KLLRLSSSQGTIESS S511
S527-p
QDIDSRLsPGGSLAD
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • transcription, inhibited
Putative in vivo kinases:
  • DYRK2 (human)
TBK1 (human) QDIDSRLsPGGSLAD S527-p
TBK1 (mouse) QDISSRLSPGGLLAD S527
TBK1 (rat) QDINSRLSPGGSLAD S527
K545-ub
HQEGTHPkDRNVEKL
0 1
TBK1 (human) HQEGTHPkDRNVEKL K545-ub
TBK1 (mouse) HQEGTHPRDRNVEKL R545
TBK1 (rat) HQEGTHPRDRNVEKL R545
Y577-p
KAERRLAyNEEQIHk
1 1
TBK1 (human) KAERRLAyNEEQIHk Y577-p
TBK1 (mouse) KAERRLAYNEEQIHK Y577
TBK1 (rat) KAERRLAYNEEQIHK Y577
K584-ub
yNEEQIHkFDKQkLy
0 2
TBK1 (human) yNEEQIHkFDKQkLy K584-ub
TBK1 (mouse) YNEEQIHKFDKQKLY K584
TBK1 (rat) YNEEQIHKFDKQKLY K584
K589-ub
IHkFDKQkLyyHATk
0 1
TBK1 (human) IHkFDKQkLyyHATk K589-ub
TBK1 (mouse) IHKFDKQKLYYHATK K589
TBK1 (rat) IHKFDKQKLYYHATK K589
Y591-p
kFDKQkLyyHATkAM
1 1
TBK1 (human) kFDKQkLyyHATkAM Y591-p
TBK1 (mouse) KFDKQKLYYHATKAM Y591
TBK1 (rat) KFDKQKLYYHATKAM Y591
Y592-p
FDKQkLyyHATkAMT
1 1
TBK1 (human) FDKQkLyyHATkAMT Y592-p
TBK1 (mouse) FDKQKLYYHATKAMS Y592
TBK1 (rat) FDKQKLYYHATKAMT Y592
K596-ub
kLyyHATkAMTHFTD
0 1
TBK1 (human) kLyyHATkAMTHFTD K596-ub
TBK1 (mouse) KLYYHATKAMSHFSE K596
TBK1 (rat) KLYYHATKAMTHFTD K596
K608-ub
FTDECVKkYEAFLNk
0 1
TBK1 (human) FTDECVKkYEAFLNk K608-ub
TBK1 (mouse) FSEECVRKYEAFKDK K608
TBK1 (rat) FTDECVRKYEAFKDT K608
K615-ub
kYEAFLNkSEEWIRK
0 1
TBK1 (human) kYEAFLNkSEEWIRK K615-ub
TBK1 (mouse) KYEAFKDKSEEWMRK K615
TBK1 (rat) KYEAFKDTSEEWMRK T615
K646
DIEEEVSKyQEyTNE
1 1
TBK1 (human) DIEEEVSKyQEyTNE K646
TBK1 (mouse) DIEEEVSkYQDYTNE K646-ac
TBK1 (rat) DIEEEVSKYQDYTNE K646
K646-ub
DIEEEVSkyQEyTNE
0 1
TBK1 (human) DIEEEVSkyQEyTNE K646-ub
TBK1 (mouse) DIEEEVSKYQDYTNE K646
TBK1 (rat) DIEEEVSKYQDYTNE K646
Y647-p
IEEEVSkyQEyTNEL
1 1
TBK1 (human) IEEEVSkyQEyTNEL Y647-p
TBK1 (mouse) IEEEVSkYQDYTNEL Y647
TBK1 (rat) IEEEVSKYQDYTNEL Y647
Y650-p
EVSkyQEyTNELQET
1 1
TBK1 (human) EVSkyQEyTNELQET Y650-p
TBK1 (mouse) EVSkYQDYTNELQET Y650
TBK1 (rat) EVSKYQDYTNELQET Y650
K661-ub
LQETLPQkMFtASSG
1 3
TBK1 (human) LQETLPQkMFtASSG K661-ub
TBK1 (mouse) LQETLPQkMLAASGG K661-ub
TBK1 (rat) LQETLPQKMLAASSG K661
T664-p
TLPQkMFtASSGIKH
0 1
TBK1 (human) TLPQkMFtASSGIKH T664-p
TBK1 (mouse) TLPQkMLAASGGVkH A664
TBK1 (rat) TLPQKMLAASSGIKH A664
K670
FtASSGIKHTMTPIy
1 1
TBK1 (human) FtASSGIKHTMTPIy K670
TBK1 (mouse) LAASGGVkHAMAPIY K670-ub
TBK1 (rat) LAASSGIKHTVAPIY K670
Y677-p
KHTMTPIyPSSNTLV
1 1
TBK1 (human) KHTMTPIyPSSNTLV Y677-p
TBK1 (mouse) kHAMAPIYPSSNTLV Y677
TBK1 (rat) KHTVAPIYPSSNTLV Y677
K691
VEMTLGMKKLKEEME
1 1
TBK1 (human) VEMTLGMKKLKEEME K691
TBK1 (mouse) VEMTLGMkKLKEEME K691-ac
TBK1 (rat) VEMTLGMKKLKEEME K691
K702-ub
EEMEGVVkELAENNH
0 1
TBK1 (human) EEMEGVVkELAENNH K702-ub
TBK1 (mouse) EEMEGVVKELAENNH K702
TBK1 (rat) EEMEGVVKELAENNH K702
S716-p
HILERFGsLTMDGGL
Upstream
Downstream
2 20
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, altered
  • cell growth, induced
  • signaling pathway regulation
Kinase, in vitro:
  • PKCT (human)
Putative in vivo kinases:
  • PKCT (human)
Regulatory protein:
  • CARD10 (human)
  • TBKBP1 (human)
Treatment
  • EGF
  • GF109203X
  • insulin
  • serum
  • siRNA
  • sotrastaurin
TBK1 (human) HILERFGsLTMDGGL S716-p
TBK1 (mouse) HILERFGsLTMDGGL S716-p
TBK1 (rat) HILERFGSLTMDGGL S716