Other Species / Isoforms
  NUMB (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S7-p
_MNKLRQsFRRKkDV
Upstream
Downstream
2 3
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • cell motility, induced
  • endocytosis, induced
Kinase, in vitro:
  • PKCI (human)
Putative in vivo kinases:
  • PKCI (human)
Treatment
  • bisindolylmaleimide
  • calyculin_A
NUMB (human) _MNKLRQsFRRKkDV S7-p
NUMB iso2 (human) _MNKLRQSFRRKKDV S7
NUMB iso3 (human) _MNKLRQsFRRKKDV S7-p
NUMB (mouse) _MNKLRQsFRRKKDV S7-p
NUMB iso2 (mouse) _MNKLRQSFRRKKDV S7
NUMB (rat) _MNKLRQSFRRKKDV S7
K12-ub
RQsFRRKkDVyVPEA
0 1
NUMB (human) RQsFRRKkDVyVPEA K12-ub
NUMB iso2 (human) RQSFRRKKDVYVPEA K12
NUMB iso3 (human) RQsFRRKKDVYVPEA K12
NUMB (mouse) RQsFRRKKDVYVPEA K12
NUMB iso2 (mouse) RQSFRRKKDVYVPEA K12
NUMB (rat) RQSFRRKKDVYVPEA K12
Y15-p
FRRKkDVyVPEAsRP
0 23
NUMB (human) FRRKkDVyVPEAsRP Y15-p
NUMB iso2 (human) FRRKKDVYVPEASRP Y15
NUMB iso3 (human) FRRKKDVYVPEASRP Y15
NUMB (mouse) FRRKKDVYVPEASRP Y15
NUMB iso2 (mouse) FRRKKDVYVPEASRP Y15
NUMB (rat) FRRKKDVYVPEASRP Y15
S20-p
DVyVPEAsRPHQWQt
0 2
NUMB (human) DVyVPEAsRPHQWQt S20-p
NUMB iso2 (human) DVYVPEASRPHQWQT S20
NUMB iso3 (human) DVYVPEASRPHQWQT S20
NUMB (mouse) DVYVPEASRPHQWQT S20
NUMB iso2 (mouse) DVYVPEASRPHQWQT S20
NUMB (rat) DVYVPEASRPHQWQT S20
T27-p
sRPHQWQtDEEGVRT
0 1
NUMB (human) sRPHQWQtDEEGVRT T27-p
NUMB iso2 (human) SRPHQWQTDEEGVRT T27
NUMB iso3 (human) SRPHQWQTDEEGVRT T27
NUMB (mouse) SRPHQWQTDEEGVRT T27
NUMB iso2 (mouse) SRPHQWQTDEEGVRT T27
NUMB (rat) SRPHQWQTDEEGVRT T27
K36-ub
EEGVRTGkCSFPVKY
0 1
NUMB (human) EEGVRTGkCSFPVKY K36-ub
NUMB iso2 (human) EEGVRTGKCSFPVKY K36
NUMB iso3 (human) EEGVRTGKCSFPVKY K36
NUMB (mouse) EEGVRTGKCSFPVKY K36
NUMB iso2 (mouse) EEGVRTGKCSFPVKY K36
NUMB (rat) EEGVRTGKCSFPVKY K36
R53-m1
HVEVDESrGMHICED
0 1
NUMB (human) HVEVDESrGMHICED R53-m1
NUMB iso2 (human) HVEVDESRGMHICED R53
NUMB iso3 (human) HVEVDESRGMHICED R53
NUMB (mouse) HVEVDESRGMHICED R53
NUMB iso2 (mouse) HVEVDESRGMHICED R53
NUMB (rat) HVEVDESRGMHICED R53
K63-ub
HICEDAVkRLKAERK
0 1
NUMB (human) HICEDAVkRLKAERK K63-ub
NUMB iso2 (human) HICEDAVKRLKAERK K63
NUMB iso3 (human) HICEDAVKRLKATGK K63
NUMB (mouse) HICEDAVKRLKAERK K63
NUMB iso2 (mouse) HICEDAVKRLKAERK K63
NUMB (rat) HICEDAVKRLKAERK K63
K63
HICEDAVKRLKAERK
0 1
NUMB (human) HICEDAVKRLKAERK K63
NUMB iso2 (human) HICEDAVKRLKAERK K63
NUMB iso3 (human) HICEDAVkRLKATGK K63-m1
NUMB (mouse) HICEDAVKRLKAERK K63
NUMB iso2 (mouse) HICEDAVKRLKAERK K63
NUMB (rat) HICEDAVKRLKAERK K63
K73-ub
KAERKFFkGFFGKTG
0 1
NUMB (human) KAERKFFkGFFGKTG K73-ub
NUMB iso2 (human) KAERKFFKGFFGKTG K73
NUMB iso3 (human) gap -
NUMB (mouse) KAERKFFKGFFGKTG K73
NUMB iso2 (mouse) KAERKFFKGFFGKTG K73
NUMB (rat) KAERKFFKGFFGKTG K73
S91-p
VKAVLWVsADGLRVV
0 3
NUMB (human) VKAVLWVsADGLRVV S91-p
NUMB iso2 (human) VKAVLWVSADGLRVV S91
NUMB iso3 (human) VKAVLWVSADGLRVV S80
NUMB (mouse) VKAVLWVSADGLRVV S91
NUMB iso2 (mouse) VKAVLWVSADGLRVV S91
NUMB (rat) VKAVLWVSADGLRVV S91
T102-p
LRVVDEKtKDLIVDQ
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, induced
  • intracellular localization
Effects on Biological Processes:
  • endocytosis, altered
Kinase, in vitro:
  • AAK1 (human)
Putative in vivo kinases:
  • AAK1 (human)
NUMB (human) LRVVDEKtKDLIVDQ T102-p
NUMB iso2 (human) LRVVDEKTKDLIVDQ T102
NUMB iso3 (human) LRVVDEKTKDLIVDQ T91
NUMB (mouse) LRVVDEKTKDLIVDQ T102
NUMB iso2 (mouse) LRVVDEKTKDLIVDQ T102
NUMB (rat) LRVVDEKTKDLIVDQ T102
R121-m1
VSFCAPDrNFDRAFS
0 1
NUMB (human) VSFCAPDrNFDRAFS R121-m1
NUMB iso2 (human) VSFCAPDRNFDRAFS R121
NUMB iso3 (human) VSFCAPDRNFDRAFS R110
NUMB (mouse) VSFCAPDRNFDRAFS R121
NUMB iso2 (mouse) VSFCAPDRNFDRAFS R121
NUMB (rat) VSFCAPDRNFDRAFS R121
K174
ERKQKREKECGVTAT
0 1
NUMB (human) ERKQKREKECGVTAT K174
NUMB iso2 (human) ERKQKREKECGVTAT K174
NUMB iso3 (human) ERKQKREKECGVTAT K163
NUMB (mouse) ERKQKREkECGVTAT K174-ub
NUMB iso2 (mouse) ERKQKREKECGVTAT K174
NUMB (rat) ERKQKREKECGVTAT K174
T187-p
ATFDASRtTFtREGs
0 1
NUMB (human) ATFDASRtTFtREGs T187-p
NUMB iso2 (human) ATFDASRTTFTREGS T187
NUMB iso3 (human) ATFDASRTTFTREGS T176
NUMB (mouse) ATFDASRTTFTREGs T187
NUMB iso2 (mouse) ATFDASRTTFTREGS T187
NUMB (rat) ATFDASRTTFTREGS T187
T190-p
DASRtTFtREGsFRV
0 1
NUMB (human) DASRtTFtREGsFRV T190-p
NUMB iso2 (human) DASRTTFTREGSFRV T190
NUMB iso3 (human) DASRTTFTREGSFRV T179
NUMB (mouse) DASRTTFTREGsFRV T190
NUMB iso2 (mouse) DASRTTFTREGSFRV T190
NUMB (rat) DASRTTFTREGSFRV T190
S194-p
tTFtREGsFRVTTAT
0 28
NUMB (human) tTFtREGsFRVTTAT S194-p
NUMB iso2 (human) TTFTREGSFRVTTAT S194
NUMB iso3 (human) TTFTREGSFRVTTAT S183
NUMB (mouse) TTFTREGsFRVTTAT S194-p
NUMB iso2 (mouse) TTFTREGSFRVTTAT S194
NUMB (rat) TTFTREGSFRVTTAT S194
K211
AEREEIMKQMQDAKK
0 1
NUMB (human) AEREEIMKQMQDAKK K211
NUMB iso2 (human) AEREEIMKQMQDAKK K211
NUMB iso3 (human) AEREEIMKQMQDAKK K200
NUMB (mouse) AEREEIMkQLQDAKK K211-ub
NUMB iso2 (mouse) AEREEIMKQLQDAKK K211
NUMB (rat) AEREEIMKQLQDAKK K211
I224
KKAETDKIVVGSSVA
0 1
NUMB (human) KKAETDKIVVGSSVA I224
NUMB iso2 (human) KKAETDKIVVGSSVA I224
NUMB iso3 (human) KKAETDKIVVGSSVA I213
NUMB (mouse) KKAETDKtVVGPsVA T224-p
NUMB iso2 (mouse) KKAETDKTVVGPSVA T224
NUMB (rat) KKAETDKTVGPSVAP T224
S229
DKIVVGSSVAPGNTA
0 1
NUMB (human) DKIVVGSSVAPGNTA S229
NUMB iso2 (human) DKIVVGSSVAPGNTA S229
NUMB iso3 (human) DKIVVGSSVAPGNTA S218
NUMB (mouse) DKtVVGPsVAPGNTA S229-p
NUMB iso2 (mouse) DKTVVGPSVAPGNTA S229
NUMB (rat) TDKTVGPSVAPGNSA S228
S238-p
APGNTAPsPssPtsP
0 4
NUMB (human) APGNTAPsPssPtsP S238-p
NUMB iso2 (human) APGNTAPsPSSPTSP S238-p
NUMB iso3 (human) APGNTAPsPSSPTSP S227-p
NUMB (mouse) APGNTAPsPSsPtSP S238-p
NUMB iso2 (mouse) APGNTAPSPSSPTSP S238
NUMB (rat) APGNSAPSPSSPTSP S237
S240-p
GNTAPsPssPtsPtS
0 2
NUMB (human) GNTAPsPssPtsPtS S240-p
NUMB iso2 (human) GNTAPsPSSPTSPTS S240
NUMB iso3 (human) GNTAPsPSSPTSPTS S229
NUMB (mouse) GNTAPsPSsPtSPtP S240
NUMB iso2 (mouse) GNTAPSPSSPTSPTP S240
NUMB (rat) GNSAPSPSSPTSPTL S239
S241-p
NTAPsPssPtsPtSD
0 12
NUMB (human) NTAPsPssPtsPtSD S241-p
NUMB iso2 (human) NTAPsPSSPTSPTSD S241
NUMB iso3 (human) NTAPsPSSPTSPTSD S230
NUMB (mouse) NTAPsPSsPtSPtPD S241-p
NUMB iso2 (mouse) NTAPSPSSPTSPTPD S241
NUMB (rat) NSAPSPSSPTSPTLD S240
T243-p
APsPssPtsPtSDAT
0 11
NUMB (human) APsPssPtsPtSDAT T243-p
NUMB iso2 (human) APsPSSPTSPTSDAT T243
NUMB iso3 (human) APsPSSPTSPTSDAT T232
NUMB (mouse) APsPSsPtSPtPDGt T243-p
NUMB iso2 (mouse) APSPSSPTSPTPDGT T243
NUMB (rat) APSPSSPTSPTLDPT T242
S244-p
PsPssPtsPtSDATt
0 3
NUMB (human) PsPssPtsPtSDATt S244-p
NUMB iso2 (human) PsPSSPTSPTSDATT S244
NUMB iso3 (human) PsPSSPTSPTSDATT S233
NUMB (mouse) PsPSsPtSPtPDGtA S244
NUMB iso2 (mouse) PSPSSPTSPTPDGTA S244
NUMB (rat) PSPSSPTSPTLDPTA S243
T246-p
PssPtsPtSDATtSL
0 2
NUMB (human) PssPtsPtSDATtSL T246-p
NUMB iso2 (human) PSSPTSPTSDATTSL T246
NUMB iso3 (human) PSSPTSPTSDATTSL T235
NUMB (mouse) PSsPtSPtPDGtAss T246-p
NUMB iso2 (mouse) PSSPTSPTPDGTASS T246
NUMB (rat) PSSPTSPTLDPTASL T245
T250
tsPtSDATtSLEMNN
0 2
NUMB (human) tsPtSDATtSLEMNN T250
NUMB iso2 (human) TSPTSDATTSLEMNN T250
NUMB iso3 (human) TSPTSDATTSLEMNN T239
NUMB (mouse) tSPtPDGtAssEMNN T250-p
NUMB iso2 (mouse) TSPTPDGTASSEMNN T250
NUMB (rat) TSPTLDPTASLEMNN T249
T251-p
sPtSDATtSLEMNNP
0 1
NUMB (human) sPtSDATtSLEMNNP T251-p
NUMB iso2 (human) SPTSDATTSLEMNNP T251
NUMB iso3 (human) SPTSDATTSLEMNNP T240
NUMB (mouse) SPtPDGtAssEMNNP A251
NUMB iso2 (mouse) SPTPDGTASSEMNNP A251
NUMB (rat) SPTLDPTASLEMNNP A250
S252
PtSDATtSLEMNNPH
0 1
NUMB (human) PtSDATtSLEMNNPH S252
NUMB iso2 (human) PTSDATTSLEMNNPH S252
NUMB iso3 (human) PTSDATTSLEMNNPH S241
NUMB (mouse) PtPDGtAssEMNNPH S252-p
NUMB iso2 (mouse) PTPDGTASSEMNNPH S252
NUMB (rat) PTLDPTASLEMNNPH S251
L253
tSDATtSLEMNNPHA
0 1
NUMB (human) tSDATtSLEMNNPHA L253
NUMB iso2 (human) TSDATTSLEMNNPHA L253
NUMB iso3 (human) TSDATTSLEMNNPHA L242
NUMB (mouse) tPDGtAssEMNNPHA S253-p
NUMB iso2 (mouse) TPDGTASSEMNNPHA S253
NUMB (rat) TLDPTASLEMNNPHA L252
S276-p
EQLARQGsFRGFPAL
Upstream
4 25
NUMB (human)
S276-p
NUMB iso2 (human)
S276-p
NUMB iso3 (human)
S265-p
NUMB (mouse)
S276-p
NUMB iso2 (mouse)
S276-p
NUMB (rat)
S275-p
Kinase, in vitro:
  • CAMK1A (rat)
  • CAMK2A (rat)
  • CAMK4 (rat)
  • PKCI (human)
Putative in vivo kinases:
  • CAMK1A (rat)
Treatment
  • ionomycin
  • LRRK2-IN-1
NUMB (human) EQLARQGsFRGFPAL S276-p
NUMB iso2 (human) EQLARQGSFRGFPAL S276
NUMB iso3 (human) EQLARQGsFRGFPAL S265-p
NUMB (mouse) EQLARQGsFRGFPAL S276-p
NUMB iso2 (mouse) EQLARQGSFRGFPAL S276
NUMB (rat) EQLARQGsFRGFPAL S275-p
S284-p
FRGFPALsQkMsPFK
0 4
NUMB (human) FRGFPALsQkMsPFK S284-p
NUMB iso2 (human) FRGFPALSQKMsPFK S284
NUMB iso3 (human) FRGFPALSQKMsPFK S273
NUMB (mouse) FRGFPALsQkMsPFK S284-p
NUMB iso2 (mouse) FRGFPALSQKMSPFK S284
NUMB (rat) FRGFPALSQKMSPFK S283
K286-ub
GFPALsQkMsPFKRQ
0 2
NUMB (human) GFPALsQkMsPFKRQ K286-ub
NUMB iso2 (human) GFPALSQKMsPFKRQ K286
NUMB iso3 (human) GFPALSQKMsPFKRQ K275
NUMB (mouse) GFPALsQkMsPFKRQ K286-ub
NUMB iso2 (mouse) GFPALSQKMSPFKRQ K286
NUMB (rat) GFPALSQKMSPFKRQ K285
S288-p
PALsQkMsPFKRQLs
0 5
NUMB (human) PALsQkMsPFKRQLs S288-p
NUMB iso2 (human) PALSQKMsPFKRQLS S288-p
NUMB iso3 (human) PALSQKMsPFKRQLs S277-p
NUMB (mouse) PALsQkMsPFKRQLs S288-p
NUMB iso2 (mouse) PALSQKMSPFKRQLS S288
NUMB (rat) PALSQKMSPFKRQLs S287
S295-p
sPFKRQLsLRINELP
Upstream
4 25
Kinase, in vitro:
  • PKCI (human)
NUMB (human) sPFKRQLsLRINELP S295-p
NUMB iso2 (human) sPFKRQLSLRINELP S295
NUMB iso3 (human) sPFKRQLsLRINELP S284-p
NUMB (mouse) sPFKRQLsLRINELP S295-p
NUMB iso2 (mouse) SPFKRQLSLRINELP S295
NUMB (rat) SPFKRQLsLRINELP S294-p
S361-p
VTVVAPQsPTFQANG
0 8
NUMB (human) VTVVAPQsPTFQANG S361-p
NUMB iso2 (human) VTVVAPQsPtFQGtE S361-p
NUMB iso3 (human) VTVVAPQSPTFQANG S350
NUMB (mouse) VTLVAPQSPVLQANG S362
NUMB iso2 (mouse) VTLVAPQsPVLQGTE S362-p
NUMB (rat) VTLVAPQSPVLQANG S361
T363
VVAPQsPTFQANGTD
0 1
NUMB (human) VVAPQsPTFQANGTD T363
NUMB iso2 (human) VVAPQsPtFQGtEWG T363-p
NUMB iso3 (human) VVAPQSPTFQANGTD T352
NUMB (mouse) LVAPQSPVLQANGTD V364
NUMB iso2 (mouse) LVAPQsPVLQGTEWG V364
NUMB (rat) LVAPQSPVLQANGTD V363
T415
IAATCSGTEWGQSSG
0 1
NUMB (human) IAATCSGTEWGQSSG T415
NUMB iso2 (human) QsPtFQGtEWGQSSG T367-p
NUMB iso3 (human) IAATCSGTEWGQSSG T404
NUMB (mouse) IAAIHPGTEWGQSSG T417
NUMB iso2 (mouse) QsPVLQGTEWGQSSG T368
NUMB (rat) IAAIHSGTEWGQSSG T416
S425-p
GQSSGAAsPGLFQAG
0 31
NUMB (human) GQSSGAAsPGLFQAG S425-p
NUMB iso2 (human) GQSSGAAsPGLFQAG S377-p
NUMB iso3 (human) GQSSGAASPGLFQAG S414
NUMB (mouse) GQSSGAAsPGLFQAG S427-p
NUMB iso2 (mouse) GQSSGAAsPGLFQAG S378-p
NUMB (rat) GQSSGAASPGLFQAG S426
T436-p
FQAGHRRtPsEADRW
Upstream
0 46
Treatment
  • ischemia
NUMB (human) FQAGHRRtPsEADRW T436-p
NUMB iso2 (human) FQAGHRRTPSEADRW T388
NUMB iso3 (human) FQAGHRRtPsEADRW T425-p
NUMB (mouse) FQAGHRRtPsEADRW T438-p
NUMB iso2 (mouse) FQAGHRRTPSEADRW T389
NUMB (rat) FQAGHRRTPsEADRW T437
S438-p
AGHRRtPsEADRWLE
Upstream
0 95
Treatment
  • ischemia
NUMB (human) AGHRRtPsEADRWLE S438-p
NUMB iso2 (human) AGHRRTPSEADRWLE S390
NUMB iso3 (human) AGHRRtPsEADRWLE S427-p
NUMB (mouse) AGHRRtPsEADRWLE S440-p
NUMB iso2 (mouse) AGHRRTPSEADRWLE S391
NUMB (rat) AGHRRTPsEADRWLE S439-p
S448-p
DRWLEEVsKSVRAQQ
0 1
NUMB (human) DRWLEEVsKSVRAQQ S448-p
NUMB iso2 (human) DRWLEEVSKSVRAQQ S400
NUMB iso3 (human) DRWLEEVSKSVRAQQ S437
NUMB (mouse) DRWLEEVSKSVRAQQ S450
NUMB iso2 (mouse) DRWLEEVSKSVRAQQ S401
NUMB (rat) DRWLEEVSKSVRAQQ S449
T561-p
PSLVRQQtFPHYEAS
0 8
NUMB (human) PSLVRQQtFPHYEAS T561-p
NUMB iso2 (human) PSLVRQQTFPHYEAS T513
NUMB iso3 (human) PSLVRQQtFPHYEAS T550-p
NUMB (mouse) PSLAKQQTFPQYETS T563
NUMB iso2 (mouse) PSLAKQQTFPQYETS T514
NUMB (rat) PSLAKQQTFPQYETS T562
T631-p
ENKSKQRtNPsPTNP
0 3
NUMB (human) ENKSKQRtNPsPTNP T631-p
NUMB iso2 (human) ENKSKQRTNPSPTNP T583
NUMB iso3 (human) ENKSKQRTNPSPTNP T620
NUMB (mouse) ESKSKQRTNPsPtNP T633
NUMB iso2 (mouse) ESKSKQRTNPSPTNP T584
NUMB (rat) ESKPKQRtNPsPTNP T632-p
S634-p
SKQRtNPsPTNPFSS
Upstream
0 28
Treatment
  • ischemia
NUMB (human) SKQRtNPsPTNPFSS S634-p
NUMB iso2 (human) SKQRTNPSPTNPFSS S586
NUMB iso3 (human) SKQRTNPSPTNPFSS S623
NUMB (mouse) SKQRTNPsPtNPFSS S636-p
NUMB iso2 (mouse) SKQRTNPSPTNPFSS S587
NUMB (rat) PKQRtNPsPTNPFSS S635-p
T636
QRtNPsPTNPFSSDL
0 1
NUMB (human) QRtNPsPTNPFSSDL T636
NUMB iso2 (human) QRTNPSPTNPFSSDL T588
NUMB iso3 (human) QRTNPSPTNPFSSDL T625
NUMB (mouse) QRTNPsPtNPFSSDL T638-p
NUMB iso2 (mouse) QRTNPSPTNPFSSDL T589
NUMB (rat) QRtNPsPTNPFSSDA T637