Other Species / Isoforms
  NLRP3 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S5-p
___MKMAsTRCKLAR
Upstream
Downstream
4 1
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • signaling pathway regulation
Putative in vivo kinases:
  • Akt1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
NLRP3 (human) ___MKMAsTRCKLAR S5-p
NLRP3 (mouse) _____MTsVRCKLAQ S3-p
NLRP3 (rat) ___MKMMSVRCKLAQ S5
Y13-p
TRCKLARyLEDLEDV
1 1
NLRP3 (human) TRCKLARyLEDLEDV Y13-p
NLRP3 (mouse) VRCKLAQYLEDLEDV Y11
NLRP3 (rat) VRCKLAQYLEDLEDV Y13
K24
LEDVDLKKFKMHLED
1 1
NLRP3 (human) LEDVDLKKFKMHLED K24
NLRP3 (mouse) LEDVDLKkFKMHLED K22-ac
NLRP3 (rat) LEDVDLKKFKMHLED K24
Y136
ICKMKKDYRKKYRKY
1 0
NLRP3 (human) ICKMKKDYRKKYRKY Y136
NLRP3 (mouse) ICKKKKDyCKMYRRH Y132-p
NLRP3 (rat) ICKKKKDYCKIYRRH Y134
S161-p
RNARLGEsVsLNKRY
1 1
NLRP3 (human) RNARLGEsVsLNKRY S161-p
NLRP3 (mouse) RNARLGESVDLNSRY S157
NLRP3 (rat) RNARLGESVDLNRRY S159
S163-p
ARLGEsVsLNKRYTR
Upstream
2 2
Kinase, in vitro:
  • PAK1 (human)
NLRP3 (human) ARLGEsVsLNKRYTR S163-p
NLRP3 (mouse) ARLGESVDLNSRYTQ D159
NLRP3 (rat) ARLGESVDLNRRYTQ D161
S198-p
GKTKTCEsPVSPIKM
Upstream
Downstream
5 2
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
  • protein conformation
  • ubiquitination
Kinase, in vitro:
  • JNK1 (human)
  • PAK1 (human)
Putative in vivo kinases:
  • JNK1 (human)
Treatment
  • LPS
  • monosodium urate
  • nigericin
NLRP3 (human) GKTKTCEsPVSPIKM S198-p
NLRP3 (mouse) GRTKMRDsPMSSLKL S194-p
NLRP3 (rat) GRTKMWDRPMSSLKL R196
T233-p
GAAGIGKtILARKMM
0 1
NLRP3 (human) GAAGIGKtILARKMM T233-p
NLRP3 (mouse) GAAGIGKTILARKIM T229
NLRP3 (rat) GAAGIGKTILARKIM T231
S295-p
HKIVRKPsRILFLMD
Upstream
Downstream
5 2
Effects on Modified Protein
  • activity, inhibited
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
  • PKACA (mouse)
Treatment
  • ANP
  • ATP
  • BNP
  • cGMP_analog
  • KT5823
  • LPS
NLRP3 (human) HKIVRKPsRILFLMD S295-p
NLRP3 (mouse) CKILRKPsRILFLMD S291-p
NLRP3 (rat) CKILCKPSRILFLMD S293
K324-ub
PLCTDWQkAERGDIL
Downstream
1 0
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
NLRP3 (human) PLCTDWQkAERGDIL K324-ub
NLRP3 (mouse) EVCTDWQKAVRGDIL K320
NLRP3 (rat) EVCTDWQKAVRGDIL K322
S334-p
RGDILLSsLIRKKLL
2 1
NLRP3 (human) RGDILLSsLIRKKLL S334-p
NLRP3 (mouse) RGDILLSsLIRKKLL S330-p
NLRP3 (rat) RGDILLSSLIRKKLL S332
K384
KRKEYFFKYFsDEAQ
1 0
NLRP3 (human) KRKEYFFKYFsDEAQ K384
NLRP3 (mouse) KRKEYFFkYFSNELQ K380-ub
NLRP3 (rat) KRKEYFFKYFSNELQ K382
S387-p
EYFFKYFsDEAQARA
0 1
NLRP3 (human) EYFFKYFsDEAQARA S387-p
NLRP3 (mouse) EYFFkYFSNELQARE S383
NLRP3 (rat) EYFFKYFSNELQARE S385
K430-ub
KQQMESGkSLAQTsK
Downstream
1 0
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
NLRP3 (human) KQQMESGkSLAQTsK K430-ub
NLRP3 (mouse) KQQMETGKSLAQTSK K426
NLRP3 (rat) KQQMETGKSLAQTSK K428
S436-p
GkSLAQTsKTTTAVY
0 1
NLRP3 (human) GkSLAQTsKTTTAVY S436-p
NLRP3 (mouse) GKSLAQTSKTTTAVY S432
NLRP3 (rat) GKSLAQTSKTTTAVY S434
K496-ub
LRNHGLQkADVSAFL
Downstream
2 2
Effects on Modified Protein
  • protein degradation
NLRP3 (human) LRNHGLQkADVSAFL K496-ub
NLRP3 (mouse) LRKHGLQKTDVSAFL K492
NLRP3 (rat) LRKHGLQKTDVSAFL K494
K567
VLLENYGKFEKGYLI
1 0
NLRP3 (human) VLLENYGKFEKGYLI K567
NLRP3 (mouse) VLLENYGkFEKGYLI K565-ub
NLRP3 (rat) VLLENYGKFEKGYLI K567
T659-p
KIEINLStRMDHMVS
Upstream
Downstream
1 1
Effects on Modified Protein
  • activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • PAK1 (human)
Putative in vivo kinases:
  • PAK1 (human)
Treatment
  • AZ13711265
  • FRAX597
  • IPA-3
  • siRNA
NLRP3 (human) KIEINLStRMDHMVS T659-p
NLRP3 (mouse) KIEINLSTRMDHVVS T657
NLRP3 (rat) KIEINLSTRMDHVVS T659
K689
GFLHNMPKEEEEEEK
1 0
NLRP3 (human) GFLHNMPKEEEEEEK K689
NLRP3 (mouse) GFFHNSPkEEEEERR K687-ub
NLRP3 (rat) GFLHNSPKEEEEEKR K689
S728-p
VNSHLTSsFCRGLFs
3 4
NLRP3 (human) VNSHLTSsFCRGLFs S728-p
NLRP3 (mouse) VNCCLTSsFCRGLFS S725-p
NLRP3 (rat) VNCCLTSSFCRGLFS S727
S735-p
sFCRGLFsVLSTSQS
1 1
NLRP3 (human) sFCRGLFsVLSTSQS S735-p
NLRP3 (mouse) sFCRGLFSSLSTNRS S732
NLRP3 (rat) SFCRGLFSSLSTNQS S734
S806-p
KLVELDLsDNALGDF
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Putative in vivo kinases:
  • CK1A (human)
Treatment
  • D4476
  • LPS
  • nigericin
  • siRNA
NLRP3 (human) KLVELDLsDNALGDF S806-p
NLRP3 (mouse) KLVELDLsDNALGDF S803-p
NLRP3 (rat) KLVELDLSDNALGDF S805
Y861-p
SHSLTRLyVGENALG
Upstream
Downstream
1 0
Effects on Modified Protein
  • activity, inhibited
Phosphatases, in vitro:
  • PTPN22 (human)
Putative upstream phosphatases:
  • PTPN22 (human)
Regulatory protein:
  • PYCARD (human)
Treatment
  • ATP
  • dextran sulphate sodium
  • LPS
  • monosodium urate
  • muramyl_dipeptide
NLRP3 (human) SHSLTRLyVGENALG Y861-p
NLRP3 (mouse) NHSLTRLYIGENALG Y858
NLRP3 (rat) NHSLTRLYIGENALG Y860
K878-ub
GVAILCEkAKNPQCN
1 1
NLRP3 (human) GVAILCEkAKNPQCN K878-ub
NLRP3 (mouse) GVQVLCEKMKDPQCN K875
NLRP3 (rat) GVQVLCEKMKDPQCN K877
K927-ub
RGNTLGDkGIKLLCE
1 1
NLRP3 (human) RGNTLGDkGIKLLCE K927-ub
NLRP3 (mouse) RSNALGDTGLRLLCE T924
NLRP3 (rat) RSNALGDMGLKLLCE M926
K973-ub
TSSQSLRkLsLGNND
1 1
NLRP3 (human) TSSQSLRkLsLGNND K973-ub
NLRP3 (mouse) THNHSLRKLNLGNND K970
NLRP3 (rat) THNQSLRKLNLSNND K972
S975-p
SQSLRkLsLGNNDLG
1 1
NLRP3 (human) SQSLRkLsLGNNDLG S975-p
NLRP3 (mouse) NHSLRKLNLGNNDLG N972
NLRP3 (rat) NQSLRKLNLSNNDLG N974
S1035-p
LTVVFEPsW______
1 1
NLRP3 (human) LTVVFEPsW______ S1035-p
NLRP3 (mouse) LTIVFEISW______ S1032
NLRP3 (rat) LTVVFEISW______ S1034