Other Species / Isoforms
  MTHFR (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S10
NEARGNSSLNPCLEG
0 1
MTHFR (human) NEARGNSSLNPCLEG S10
MTHFR iso2 (human) NEARGNSSLNPCLEG S51
MTHFR (mouse) NEARGSGsPNPRSEG S10-p
MTHFR (rat) NEARRSGSPSPRSEG S51
T34-p
KDSSRCStPGLDPER
Upstream
Downstream
3 4
Effects on Modified Protein
  • activity, inhibited
  • enzymatic activity, inhibited
  • molecular association, regulation
Kinase, in vitro:
  • CDK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
Treatment
  • AZD5438
MTHFR (human) KDSSRCStPGLDPER T34-p
MTHFR iso2 (human) KDSSRCSTPGLDPER T75
MTHFR (mouse) KDSSRCSTPSLDPER T33
MTHFR (rat) KDSSRCSTPSLDPDR T74
Y90-p
MAAGGPLyIDVTWHP
0 1
MTHFR (human) MAAGGPLyIDVTWHP Y90-p
MTHFR iso2 (human) MAAGGPLYIDVTWHP Y131
MTHFR (mouse) MAAGGPLFVDVTWHP F89
MTHFR (rat) MAAGGPLFVDVTWHP F130
K151-ub
KAKQLGLkNIMALRG
0 1
MTHFR (human) KAKQLGLkNIMALRG K151-ub
MTHFR iso2 (human) KAKQLGLKNIMALRG K192
MTHFR (mouse) RAKQLGLKNIMALRG K150
MTHFR (rat) RAKQLGLKNIMALRG K191
K212-ub
GSFEADLkHLKEKVS
0 1
MTHFR (human) GSFEADLkHLKEKVS K212-ub
MTHFR iso2 (human) GSFEADLKHLKEKVS K253
MTHFR (mouse) ESFEDDLKHLKEKVS K211
MTHFR (rat) ESFEDDLKHLKEKVS K252
D234
TQLFFEADTFFRFVK
0 1
MTHFR (human) TQLFFEADTFFRFVK D234
MTHFR iso2 (human) TQLFFEADTFFRFVK D275
MTHFR (mouse) TQLFFEAstFFsFVK S233-p
MTHFR (rat) TQLFFEASSFFSFVK S274
T235
QLFFEADTFFRFVKA
0 1
MTHFR (human) QLFFEADTFFRFVKA T235
MTHFR iso2 (human) QLFFEADTFFRFVKA T276
MTHFR (mouse) QLFFEAstFFsFVKA T234-p
MTHFR (rat) QLFFEASSFFSFVKA S275
R238
FEADTFFRFVKACTD
0 1
MTHFR (human) FEADTFFRFVKACTD R238
MTHFR iso2 (human) FEADTFFRFVKACTD R279
MTHFR (mouse) FEAstFFsFVKACTE S237-p
MTHFR (rat) FEASSFFSFVKACED S278
K273-ub
RQLVKLSkLEVPQEI
0 1
MTHFR (human) RQLVKLSkLEVPQEI K273-ub
MTHFR iso2 (human) RQLVKLSKLEVPQEI K314
MTHFR (mouse) RQLVKLSKLEVPQKI K272
MTHFR (rat) RQLVKLSKLEVPQTI K313
K281-ub
LEVPQEIkDVIEPIk
0 1
MTHFR (human) LEVPQEIkDVIEPIk K281-ub
MTHFR iso2 (human) LEVPQEIKDVIEPIK K322
MTHFR (mouse) LEVPQKIKDVIEPIK K280
MTHFR (rat) LEVPQTIKDVIEPIK K321
K288-ub
kDVIEPIkDNDAAIR
0 1
MTHFR (human) kDVIEPIkDNDAAIR K288-ub
MTHFR iso2 (human) KDVIEPIKDNDAAIR K329
MTHFR (mouse) KDVIEPIKDNDAAIR K287
MTHFR (rat) KDVIEPIKDNDAAIR K328
T329-p
TLNREMAttEVLKRL
0 1
MTHFR (human) TLNREMAttEVLKRL T329-p
MTHFR iso2 (human) TLNREMATTEVLKRL T370
MTHFR (mouse) TLNREVATMEVLKQL T328
MTHFR (rat) TLNREVATMEVLKQL T369
T330-p
LNREMAttEVLKRLG
0 1
MTHFR (human) LNREMAttEVLKRLG T330-p
MTHFR iso2 (human) LNREMATTEVLKRLG T371
MTHFR (mouse) LNREVATMEVLKQLG M329
MTHFR (rat) LNREVATMEVLKQLG M370
K372-ub
IFWASRPkSYIYRTQ
0 1
MTHFR (human) IFWASRPkSYIYRTQ K372-ub
MTHFR iso2 (human) IFWASRPKSYIYRTQ K413
MTHFR (mouse) IFWASRPKSYIYRTQ K371
MTHFR (rat) IFWASRPKSYIYRTQ K412
S412
LFYLKSKSPKEELLK
0 1
MTHFR (human) LFYLKSKSPKEELLK S412
MTHFR iso2 (human) LFYLKSKSPKEELLK S453
MTHFR (mouse) LFYLKSKsPREELLK S411-p
MTHFR (rat) LFYLKSKSPREELLK S452
K468-ub
AAETSLLkEELLRVN
0 1
MTHFR (human) AAETSLLkEELLRVN K468-ub
MTHFR iso2 (human) AAETSLLKEELLRVN K509
MTHFR (mouse) AAETSLMKEELLRVN K467
MTHFR (rat) AAETSLMKEELLRVN K508
T549-p
NVKGENItNAPELQP
Upstream
Downstream
1 0
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
MTHFR (human) NVKGENItNAPELQP T549-p
MTHFR iso2 (human) NVKGENITNAPELQP T590
MTHFR (mouse) DVKGENITNAPELQP T548
MTHFR (rat) DVKGENITNAPELQP T589