Other Species / Isoforms
  MST2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K13-ub
APKSKLKkLsEDsLT
0 1
MST2 (human) APKSKLKkLsEDsLT K13-ub
MST2 iso2 (human) KQDSKLKKLSEDSLT K41
MST2 (mouse) ASKSKLKKLsEDSLT K13
MST2 (rat) APKSKLKKLSEDSLT K13
S15-p
KSKLKkLsEDsLTkQ
Upstream
1 14
Treatment
  • MG132
MST2 (human) KSKLKkLsEDsLTkQ S15-p
MST2 iso2 (human) DSKLKKLSEDSLTKQ S43
MST2 (mouse) KSKLKKLsEDSLTKQ S15-p
MST2 (rat) KSKLKKLSEDSLTKQ S15
S18-p
LKkLsEDsLTkQPEE
1 1
MST2 (human) LKkLsEDsLTkQPEE S18-p
MST2 iso2 (human) LKKLSEDSLTKQPEE S46
MST2 (mouse) LKKLsEDSLTKQPEE S18
MST2 (rat) LKKLSEDSLTKQPEE S18
K21-ub
LsEDsLTkQPEEVFD
0 1
MST2 (human) LsEDsLTkQPEEVFD K21-ub
MST2 iso2 (human) LSEDSLTKQPEEVFD K49
MST2 (mouse) LsEDSLTKQPEEVFD K21
MST2 (rat) LSEDSLTKQPEEVFD K21
K32-ub
EVFDVLEkLGEGSYG
0 1
MST2 (human) EVFDVLEkLGEGSYG K32-ub
MST2 iso2 (human) EVFDVLEKLGEGSYG K60
MST2 (mouse) EVFDVLEKLGEGSYG K32
MST2 (rat) EVFDVLEKLGEGSYG K32
K43-ub
GSYGSVFkAIHkESG
0 1
MST2 (human) GSYGSVFkAIHkESG K43-ub
MST2 iso2 (human) GSYGSVFKAIHKESG K71
MST2 (mouse) GSYGSVFKAIHKESG K43
MST2 (rat) GSYGSVFKAIHKESG K43
K47-ub
SVFkAIHkESGQVVA
0 1
MST2 (human) SVFkAIHkESGQVVA K47-ub
MST2 iso2 (human) SVFKAIHKESGQVVA K75
MST2 (mouse) SVFKAIHKESGQVVA K47
MST2 (rat) SVFKAIHKESGQVVA K47
K56-ub
SGQVVAIkQVPVESD
0 2
MST2 (human) SGQVVAIkQVPVESD K56-ub
MST2 iso2 (human) SGQVVAIKQVPVESD K84
MST2 (mouse) SGQVVAIKQVPVESD K56
MST2 (rat) SGQVVAIKQVPVESD K56
Y81-p
MQQCDSPyVVKYYGS
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • Abl (human)
Putative in vivo kinases:
  • Abl (human)
Treatment
  • imatinib
MST2 (human) MQQCDSPyVVKYYGS Y81-p
MST2 iso2 (human) MQQCDSPYVVKYYGS Y109
MST2 (mouse) MQQCDSPyVVKYYGS Y81-p
MST2 (rat) MQQCDSPYVVKYYGS Y81
K116-ub
DIIRLRNktLIEDEI
0 2
MST2 (human) DIIRLRNktLIEDEI K116-ub
MST2 iso2 (human) DIIRLRNKTLIEDEI K144
MST2 (mouse) DIIRLRNKTLTEDEI K116
MST2 (rat) DIIRLRNKTLTEDEI K116
T117-p
IIRLRNktLIEDEIA
Upstream
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • carcinogenesis, induced
  • cell growth, altered
  • signaling pathway regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • PTEN (human)
Treatment
  • Akt-I-1
  • IGF-1
  • LY294002
  • serum
  • serum_starvation
MST2 (human) IIRLRNktLIEDEIA T117-p
MST2 iso2 (human) IIRLRNKTLIEDEIA T145
MST2 (mouse) IIRLRNKTLTEDEIA T117
MST2 (rat) IIRLRNKTLTEDEIA T117
K128-ub
DEIATILkSTLKGLE
0 1
MST2 (human) DEIATILkSTLKGLE K128-ub
MST2 iso2 (human) DEIATILKSTLKGLE K156
MST2 (mouse) DEIATILKSTLKGLE K128
MST2 (rat) DEIATILKSTLKGLE K128
K161-ub
LNTEGHAkLADFGVA
0 1
MST2 (human) LNTEGHAkLADFGVA K161-ub
MST2 iso2 (human) LNTEGHAKLADFGVA K189
MST2 (mouse) LNTEGHAKLADFGVA K161
MST2 (rat) LNTEGHAKLADFGVA K161
T174-p
VAGQLTDtMAkRNtV
Upstream
0 9
Treatment
  • Y27632
MST2 (human) VAGQLTDtMAkRNtV T174-p
MST2 iso2 (human) VAGQLTDTMAKRNTV T202
MST2 (mouse) VAGQLTDtMAKRNtV T174-p
MST2 (rat) VAGQLTDTMAKRNtV T174
K177-ub
QLTDtMAkRNtVIGT
0 5
MST2 (human) QLTDtMAkRNtVIGT K177-ub
MST2 iso2 (human) QLTDTMAKRNTVIGT K205
MST2 (mouse) QLTDtMAKRNtVIGT K177
MST2 (rat) QLTDTMAKRNtVIGT K177
T180-p
DtMAkRNtVIGTPFW
Upstream
Downstream
9 5
MST2 (human)
T180-p
MST2 (mouse)
T180-p
MST2 (rat)
T180-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein processing
Effects on Biological Processes:
  • apoptosis, altered
  • signaling pathway regulation
Putative in vivo kinases:
  • MST2 (human)
Regulatory protein:
  • Akt1 (human)
  • Ezrin (human)
  • FRMD6 (human)
  • LKB1 (human)
  • Merlin (human)
Treatment
  • adriamycin
  • API-2
  • doxycycline
  • IGF-1
  • LY294002
  • staurosporine
  • Z-VAD-FMK
MST2 (human) DtMAkRNtVIGTPFW T180-p
MST2 iso2 (human) DTMAKRNTVIGTPFW T208
MST2 (mouse) DtMAKRNtVIGTPFW T180-p
MST2 (rat) DTMAKRNtVIGTPFW T180-p
K243-ub
NPPPTFRkPELWSDD
0 3
MST2 (human) NPPPTFRkPELWSDD K243-ub
MST2 iso2 (human) NPPPTFRKPELWSDD K271
MST2 (mouse) NPPPTFRKPELWSDD K243
MST2 (rat) NPPPTFRKPELWSDD K243
K282-ub
HPFIKNAkPVSILRD
0 1
MST2 (human) HPFIKNAkPVSILRD K282-ub
MST2 iso2 (human) HPFIKNAKPVSILRD K310
MST2 (mouse) HPFIKNAKPVSILRD K282
MST2 (rat) HPFIKNAKPVSILRE K282
K298-ub
ITEAMEIkAKRHEEQ
0 2
MST2 (human) ITEAMEIkAKRHEEQ K298-ub
MST2 iso2 (human) ITEAMEIKAKRHEEQ K326
MST2 (mouse) IAEAMEIKAKRHEEQ K298
MST2 (rat) ITEGMEIKAKRHEEQ K298
S316-p
LEEEEENsDEDELDs
1 65
MST2 (human) LEEEEENsDEDELDs S316-p
MST2 iso2 (human) LEEEEENSDEDELDS S344
MST2 (mouse) LEEEEENsDEDELDS S316-p
MST2 (rat) LEDEEENsDEDELDS S316-p
S323-p
sDEDELDsHtMVKTS
0 1
MST2 (human) sDEDELDsHtMVKTS S323-p
MST2 iso2 (human) SDEDELDSHTMVKTS S351
MST2 (mouse) sDEDELDSHtMVKTS S323
MST2 (rat) sDEDELDSHTMVKTS S323
T325-p
EDELDsHtMVKTSVE
0 2
MST2 (human) EDELDsHtMVKTSVE T325-p
MST2 iso2 (human) EDELDSHTMVKTSVE T353
MST2 (mouse) EDELDSHtMVKTSSE T325-p
MST2 (rat) EDELDSHTMVKTSSE T325
S333-p
MVKTSVEsVGtMRAT
0 8
MST2 (human) MVKTSVEsVGtMRAT S333-p
MST2 iso2 (human) MVKTSVESVGTMRAT S361
MST2 (mouse) MVKTSSESVGtMRAT S333
MST2 (rat) MVKTSSEGVGTMRAT G333
T336-p
TSVEsVGtMRATSTM
0 40
MST2 (human) TSVEsVGtMRATSTM T336-p
MST2 iso2 (human) TSVESVGTMRATSTM T364
MST2 (mouse) TSSESVGtMRATSTM T336-p
MST2 (rat) TSSEGVGTMRATSTM T336
S369-p
LGTMVINsEDEEEED
0 1
MST2 (human) LGTMVINsEDEEEED S369-p
MST2 iso2 (human) LGTMVINSEDEEEED S397
MST2 (mouse) LGTMVINSEEEEEEE S369
MST2 (rat) LGTMVINSEDEEEED S369
T378-p
DEEEEDGtMKRNAts
Upstream
1 0
Kinase, in vitro:
  • MST2 (human)
MST2 (human) DEEEEDGtMKRNAts T378-p
MST2 iso2 (human) DEEEEDGTMKRNATS T406
MST2 (mouse) EEEEEDGTMKRNAts T384
MST2 (rat) DEEEEDGTMKRNATS T378
T384-p
GtMKRNAtsPQVQRP
Upstream
Downstream
1 43
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • signaling pathway regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • PTEN (human)
Treatment
  • Akt-I-1
  • IGF-1
  • ischemia
  • LY294002
  • serum
MST2 (human) GtMKRNAtsPQVQRP T384-p
MST2 iso2 (human) GTMKRNATSPQVQRP T412
MST2 (mouse) GTMKRNAtsPQVQRP T390-p
MST2 (rat) GTMKRNATSPQVQRP T384
S385-p
tMKRNAtsPQVQRPs
Upstream
Downstream
1 33
Effects on Biological Processes:
  • cell growth, induced
Kinase, in vitro:
  • CDK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
Treatment
  • nocodazole
  • purvalanol
  • RO-3306
MST2 (human) tMKRNAtsPQVQRPs S385-p
MST2 iso2 (human) TMKRNATSPQVQRPS S413
MST2 (mouse) TMKRNAtsPQVQRPs S391-p
MST2 (rat) TMKRNATSPQVQRPS S385
S392-p
sPQVQRPsFMDyFDK
0 11
MST2 (human) sPQVQRPsFMDyFDK S392-p
MST2 iso2 (human) SPQVQRPSFMDYFDK S420
MST2 (mouse) sPQVQRPsFMDYFDK S398-p
MST2 (rat) SPQVQRPSFMDYFDK S392
Y396-p
QRPsFMDyFDKQDFK
0 10
MST2 (human) QRPsFMDyFDKQDFK Y396-p
MST2 iso2 (human) QRPSFMDYFDKQDFK Y424
MST2 (mouse) QRPsFMDYFDKQDFK Y402
MST2 (rat) QRPSFMDYFDKQDFK Y396
S406-p
KQDFKNKsHENCNQN
0 6
MST2 (human) KQDFKNKsHENCNQN S406-p
MST2 iso2 (human) KQDFKNKSHENCNQN S434
MST2 (mouse) KQDFKNKsHENCDQS S412-p
MST2 (rat) KQDFKNKSHENCDQS S406
K430-ub
NVFPDNWkVPQDGDF
0 1
MST2 (human) NVFPDNWkVPQDGDF K430-ub
MST2 iso2 (human) NVFPDNWKVPQDGDF K458
MST2 (mouse) SVFPDNWRVPQDGDF R436
MST2 (rat) NVFPDNWRVPQDGDF R430
S444-p
FDFLKNLsLEELQMR
Upstream
0 6
Treatment
  • MG132_withdrawal
MST2 (human) FDFLKNLsLEELQMR S444-p
MST2 iso2 (human) FDFLKNLSLEELQMR S472
MST2 (mouse) FDFLKNLSLEELQMR S450
MST2 (rat) FDFLKNLSLEELQMR S444
K453-ub
EELQMRLkALDPMME
0 2
MST2 (human) EELQMRLkALDPMME K453-ub
MST2 iso2 (human) EELQMRLKALDPMME K481
MST2 (mouse) EELQMRLKALDPMME K459
MST2 (rat) EELQMRLKALDPMME K453