MST2 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

S15

KSKLKKLsEDsLTKQ

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation

Kinase, in vitro:

PLK1 (human)

Putative in vivo kinases:

PLK1 (human)

Treatment

MG132

MST2 (human)	KSKLKKLsEDsLTKQ	S15
MST2 iso2 (human)	DSKLKKLSEDSLTKQ	S43
MST2 (mouse)	KSKLKKLsEDSLTKQ	S15
MST2 (rat)	KSKLKKLSEDSLTKQ	S15

S18

LKKLsEDsLTKQPEE

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation

Kinase, in vitro:

PLK1 (human)

Putative in vivo kinases:

PLK1 (human)

MST2 (human)	LKKLsEDsLTKQPEE	S18
MST2 iso2 (human)	LKKLSEDSLTKQPEE	S46
MST2 (mouse)	LKKLsEDSLTKQPEE	S18
MST2 (rat)	LKKLSEDSLTKQPEE	S18

Y81

MQQCDSPyVVKYYGS

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation

Kinase, in vitro:

Abl (human)

Putative in vivo kinases:

Abl (human)

Treatment

imatinib

MST2 (human)	MQQCDSPyVVKYYGS	Y81
MST2 iso2 (human)	MQQCDSPYVVKYYGS	Y109
MST2 (mouse)	MQQCDSPyVVKYYGS	Y81
MST2 (rat)	MQQCDSPYVVKYYGS	Y81

T117

IIRLRNKtLIEDEIA

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, inhibited
intracellular localization
molecular association, regulation
phosphorylation

Effects on Biological Processes:

apoptosis, altered
carcinogenesis, induced
cell growth, altered
signaling pathway regulation

Kinase, in vitro:

Akt1 (human)

Putative in vivo kinases:

Akt1 (human)

Regulatory protein:

PTEN (human)

Treatment

Akt-I-1
IGF-1
LY294002
serum
serum_starvation

MST2 (human)	IIRLRNKtLIEDEIA	T117
MST2 iso2 (human)	IIRLRNKTLIEDEIA	T145
MST2 (mouse)	IIRLRNKTLTEDEIA	T117
MST2 (rat)	IIRLRNKTLTEDEIA	T117

T174

VAGQLTDtMAKRNtV

Upstream

Treatment

Y27632

MST2 (human)	VAGQLTDtMAKRNtV	T174
MST2 iso2 (human)	VAGQLTDTMAKRNTV	T202
MST2 (mouse)	VAGQLTDtMAKRNtV	T174
MST2 (rat)	VAGQLTDTMAKRNtV	T174

T180

DtMAKRNtVIGTPFW

Upstream

Downstream

MST2 (human)
T180

MST2 (mouse)
T180

MST2 (rat)
T180

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation
phosphorylation
protein processing

Effects on Biological Processes:

apoptosis, altered
signaling pathway regulation

Putative in vivo kinases:

MST2 (human)

Regulatory protein:

Akt1 (human)
Ezrin (human)
FRMD6 (human)
LKB1 (human)
Merlin (human)

Treatment

adriamycin
API-2
doxycycline
IGF-1
LY294002
staurosporine
Z-VAD-FMK

MST2 (human)	DtMAKRNtVIGTPFW	T180
MST2 iso2 (human)	DTMAKRNTVIGTPFW	T208
MST2 (mouse)	DtMAKRNtVIGTPFW	T180
MST2 (rat)	DTMAKRNtVIGTPFW	T180

S316

LEEEEENsDEDELDs

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Effects on Biological Processes:

cell cycle regulation

Kinase, in vitro:

PLK1 (human)

Putative in vivo kinases:

PLK1 (human)

MST2 (human)	LEEEEENsDEDELDs	S316
MST2 iso2 (human)	LEEEEENSDEDELDS	S344
MST2 (mouse)	LEEEEENsDEDELDS	S316
MST2 (rat)	LEDEEENsDEDELDS	S316

S323

sDEDELDsHtMVKTS

MST2 (human)	sDEDELDsHtMVKTS	S323
MST2 iso2 (human)	SDEDELDSHTMVKTS	S351
MST2 (mouse)	sDEDELDSHtMVKTS	S323
MST2 (rat)	sDEDELDSHTMVKTS	S323

T325

EDELDsHtMVKTSVE

MST2 (human)	EDELDsHtMVKTSVE	T325
MST2 iso2 (human)	EDELDSHTMVKTSVE	T353
MST2 (mouse)	EDELDSHtMVKTSSE	T325
MST2 (rat)	EDELDSHTMVKTSSE	T325

S333

MVKTSVEsVGtMRAT

MST2 (human)	MVKTSVEsVGtMRAT	S333
MST2 iso2 (human)	MVKTSVESVGTMRAT	S361
MST2 (mouse)	MVKTSSESVGtMRAT	S333
MST2 (rat)	MVKTSSEGVGTMRAT	G333

T336

TSVEsVGtMRATSTM

MST2 (human)	TSVEsVGtMRATSTM	T336
MST2 iso2 (human)	TSVESVGTMRATSTM	T364
MST2 (mouse)	TSSESVGtMRATSTM	T336
MST2 (rat)	TSSEGVGTMRATSTM	T336

S369

LGTMVINsEDEEEED

MST2 (human)	LGTMVINsEDEEEED	S369
MST2 iso2 (human)	LGTMVINSEDEEEED	S397
MST2 (mouse)	LGTMVINSEEEEEEE	S369
MST2 (rat)	LGTMVINSEDEEEED	S369

T378

DEEEEDGtMKRNAts

Upstream

Kinase, in vitro:

MST2 (human)

MST2 (human)	DEEEEDGtMKRNAts	T378
MST2 iso2 (human)	DEEEEDGTMKRNATS	T406
MST2 (mouse)	EEEEEDGTMKRNAts	T384
MST2 (rat)	DEEEEDGTMKRNATS	T378

T384

GtMKRNAtsPQVQRP

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, inhibited
molecular association, regulation

Effects on Biological Processes:

apoptosis, altered
signaling pathway regulation

Kinase, in vitro:

Akt1 (human)

Putative in vivo kinases:

Akt1 (human)

Regulatory protein:

PTEN (human)

Treatment

Akt-I-1
IGF-1
ischemia
LY294002
serum

MST2 (human)	GtMKRNAtsPQVQRP	T384
MST2 iso2 (human)	GTMKRNATSPQVQRP	T412
MST2 (mouse)	GTMKRNAtsPQVQRP	T390
MST2 (rat)	GTMKRNATSPQVQRP	T384

S385

tMKRNAtsPQVQRPs

Upstream

Downstream

Effects on Biological Processes:

cell growth, induced

Kinase, in vitro:

CDK1 (human)

Putative in vivo kinases:

CDK1 (human)

Treatment

nocodazole
purvalanol
RO-3306

MST2 (human)	tMKRNAtsPQVQRPs	S385
MST2 iso2 (human)	TMKRNATSPQVQRPS	S413
MST2 (mouse)	TMKRNAtsPQVQRPs	S391
MST2 (rat)	TMKRNATSPQVQRPS	S385

S392

sPQVQRPsFMDyFDK

MST2 (human)	sPQVQRPsFMDyFDK	S392
MST2 iso2 (human)	SPQVQRPSFMDYFDK	S420
MST2 (mouse)	sPQVQRPsFMDYFDK	S398
MST2 (rat)	SPQVQRPSFMDYFDK	S392

Y396

QRPsFMDyFDKQDFK

MST2 (human)	QRPsFMDyFDKQDFK	Y396
MST2 iso2 (human)	QRPSFMDYFDKQDFK	Y424
MST2 (mouse)	QRPsFMDYFDKQDFK	Y402
MST2 (rat)	QRPSFMDYFDKQDFK	Y396

S406

KQDFKNKsHENCNQN

MST2 (human)	KQDFKNKsHENCNQN	S406
MST2 iso2 (human)	KQDFKNKSHENCNQN	S434
MST2 (mouse)	KQDFKNKsHENCDQS	S412
MST2 (rat)	KQDFKNKSHENCDQS	S406

S444

FDFLKNLsLEELQMR

Upstream

Treatment

MG132_withdrawal

MST2 (human)	FDFLKNLsLEELQMR	S444
MST2 iso2 (human)	FDFLKNLSLEELQMR	S472
MST2 (mouse)	FDFLKNLSLEELQMR	S450
MST2 (rat)	FDFLKNLSLEELQMR	S444