Other Species / Isoforms
  MST2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S15
KSKLKKLsEDsLTKQ
Upstream
Downstream
2 15
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
Treatment
  • MG132
MST2 (human) KSKLKKLsEDsLTKQ S15
MST2 iso2 (human) DSKLKKLSEDSLTKQ S43
MST2 (mouse) KSKLKKLsEDSLTKQ S15
MST2 (rat) KSKLKKLSEDSLTKQ S15
S18
LKKLsEDsLTKQPEE
Upstream
Downstream
1 2
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
MST2 (human) LKKLsEDsLTKQPEE S18
MST2 iso2 (human) LKKLSEDSLTKQPEE S46
MST2 (mouse) LKKLsEDSLTKQPEE S18
MST2 (rat) LKKLSEDSLTKQPEE S18
Y81
MQQCDSPyVVKYYGS
Upstream
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • Abl (human)
Putative in vivo kinases:
  • Abl (human)
Treatment
  • imatinib
MST2 (human) MQQCDSPyVVKYYGS Y81
MST2 iso2 (human) MQQCDSPYVVKYYGS Y109
MST2 (mouse) MQQCDSPyVVKYYGS Y81
MST2 (rat) MQQCDSPYVVKYYGS Y81
T117
IIRLRNKtLIEDEIA
Upstream
Downstream
2 1
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, altered
  • carcinogenesis, induced
  • cell growth, altered
  • signaling pathway regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • PTEN (human)
Treatment
  • Akt-I-1
  • IGF-1
  • LY294002
  • serum
  • serum_starvation
MST2 (human) IIRLRNKtLIEDEIA T117
MST2 iso2 (human) IIRLRNKTLIEDEIA T145
MST2 (mouse) IIRLRNKTLTEDEIA T117
MST2 (rat) IIRLRNKTLTEDEIA T117
T174
VAGQLTDtMAKRNtV
Upstream
0 9
Treatment
  • Y27632
MST2 (human) VAGQLTDtMAKRNtV T174
MST2 iso2 (human) VAGQLTDTMAKRNTV T202
MST2 (mouse) VAGQLTDtMAKRNtV T174
MST2 (rat) VAGQLTDTMAKRNtV T174
T180
DtMAKRNtVIGTPFW
Upstream
Downstream
10 5
MST2 (human)
T180
MST2 (mouse)
T180
MST2 (rat)
T180
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein processing
Effects on Biological Processes:
  • apoptosis, altered
  • signaling pathway regulation
Putative in vivo kinases:
  • MST2 (human)
Regulatory protein:
  • Akt1 (human)
  • Ezrin (human)
  • FRMD6 (human)
  • LKB1 (human)
  • Merlin (human)
Treatment
  • adriamycin
  • API-2
  • doxycycline
  • IGF-1
  • LY294002
  • staurosporine
  • Z-VAD-FMK
MST2 (human) DtMAKRNtVIGTPFW T180
MST2 iso2 (human) DTMAKRNTVIGTPFW T208
MST2 (mouse) DtMAKRNtVIGTPFW T180
MST2 (rat) DTMAKRNtVIGTPFW T180
S316
LEEEEENsDEDELDs
Upstream
Downstream
1 67
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK1 (human)
Putative in vivo kinases:
  • PLK1 (human)
MST2 (human) LEEEEENsDEDELDs S316
MST2 iso2 (human) LEEEEENSDEDELDS S344
MST2 (mouse) LEEEEENsDEDELDS S316
MST2 (rat) LEDEEENsDEDELDS S316
S323
sDEDELDsHtMVKTS
0 1
MST2 (human) sDEDELDsHtMVKTS S323
MST2 iso2 (human) SDEDELDSHTMVKTS S351
MST2 (mouse) sDEDELDSHtMVKTS S323
MST2 (rat) sDEDELDSHTMVKTS S323
T325
EDELDsHtMVKTSVE
0 3
MST2 (human) EDELDsHtMVKTSVE T325
MST2 iso2 (human) EDELDSHTMVKTSVE T353
MST2 (mouse) EDELDSHtMVKTSSE T325
MST2 (rat) EDELDSHTMVKTSSE T325
S333
MVKTSVEsVGtMRAT
0 8
MST2 (human) MVKTSVEsVGtMRAT S333
MST2 iso2 (human) MVKTSVESVGTMRAT S361
MST2 (mouse) MVKTSSESVGtMRAT S333
MST2 (rat) MVKTSSEGVGTMRAT G333
T336
TSVEsVGtMRATSTM
0 40
MST2 (human) TSVEsVGtMRATSTM T336
MST2 iso2 (human) TSVESVGTMRATSTM T364
MST2 (mouse) TSSESVGtMRATSTM T336
MST2 (rat) TSSEGVGTMRATSTM T336
S369
LGTMVINsEDEEEED
0 1
MST2 (human) LGTMVINsEDEEEED S369
MST2 iso2 (human) LGTMVINSEDEEEED S397
MST2 (mouse) LGTMVINSEEEEEEE S369
MST2 (rat) LGTMVINSEDEEEED S369
T378
DEEEEDGtMKRNAts
Upstream
1 0
Kinase, in vitro:
  • MST2 (human)
MST2 (human) DEEEEDGtMKRNAts T378
MST2 iso2 (human) DEEEEDGTMKRNATS T406
MST2 (mouse) EEEEEDGTMKRNAts T384
MST2 (rat) DEEEEDGTMKRNATS T378
T384
GtMKRNAtsPQVQRP
Upstream
Downstream
1 43
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • signaling pathway regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • PTEN (human)
Treatment
  • Akt-I-1
  • IGF-1
  • ischemia
  • LY294002
  • serum
MST2 (human) GtMKRNAtsPQVQRP T384
MST2 iso2 (human) GTMKRNATSPQVQRP T412
MST2 (mouse) GTMKRNAtsPQVQRP T390
MST2 (rat) GTMKRNATSPQVQRP T384
S385
tMKRNAtsPQVQRPs
Upstream
Downstream
1 33
Effects on Biological Processes:
  • cell growth, induced
Kinase, in vitro:
  • CDK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
Treatment
  • nocodazole
  • purvalanol
  • RO-3306
MST2 (human) tMKRNAtsPQVQRPs S385
MST2 iso2 (human) TMKRNATSPQVQRPS S413
MST2 (mouse) TMKRNAtsPQVQRPs S391
MST2 (rat) TMKRNATSPQVQRPS S385
S392
sPQVQRPsFMDyFDK
0 11
MST2 (human) sPQVQRPsFMDyFDK S392
MST2 iso2 (human) SPQVQRPSFMDYFDK S420
MST2 (mouse) sPQVQRPsFMDYFDK S398
MST2 (rat) SPQVQRPSFMDYFDK S392
Y396
QRPsFMDyFDKQDFK
0 10
MST2 (human) QRPsFMDyFDKQDFK Y396
MST2 iso2 (human) QRPSFMDYFDKQDFK Y424
MST2 (mouse) QRPsFMDYFDKQDFK Y402
MST2 (rat) QRPSFMDYFDKQDFK Y396
S406
KQDFKNKsHENCNQN
0 6
MST2 (human) KQDFKNKsHENCNQN S406
MST2 iso2 (human) KQDFKNKSHENCNQN S434
MST2 (mouse) KQDFKNKsHENCDQS S412
MST2 (rat) KQDFKNKSHENCDQS S406
S444
FDFLKNLsLEELQMR
Upstream
0 6
Treatment
  • MG132_withdrawal
MST2 (human) FDFLKNLsLEELQMR S444
MST2 iso2 (human) FDFLKNLSLEELQMR S472
MST2 (mouse) FDFLKNLSLEELQMR S450
MST2 (rat) FDFLKNLSLEELQMR S444