Other Species / Isoforms
  pyrin (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
G6
__MAKTLGDHLLNTL
0 2
pyrin (human) __MAKTPsDHLLstL S6-p
pyrin (mouse) __MAKTLGDHLLNTL G6
pyrin (rat) __MANTRVDHLLNTL V6
N11
TLGDHLLNTLEELLP
0 2
pyrin (human) TPsDHLLstLEELVP S11-p
pyrin (mouse) TLGDHLLNTLEELLP N11
pyrin (rat) TRVDHLLNTLEELLP N11
T12
LGDHLLNTLEELLPY
0 2
pyrin (human) PsDHLLstLEELVPY T12-p
pyrin (mouse) LGDHLLNTLEELLPY T12
pyrin (rat) RVDHLLNTLEELLPY T12
T136
QNNDESDTLPSSQAE
0 1
pyrin (human) PYGGGAAsLRCSQPE S141-p
pyrin (mouse) QNNDESDTLPSSQAE T136
pyrin (rat) QNDDESDILPPIQAE I136
K146
SSQAEVGKGPQKKSL
0 1
pyrin (human) CSQPEAGrGLSRKPL R151-m1
pyrin (mouse) SSQAEVGKGPQKKSL K146
pyrin (rat) PIQAEVGKGPQKKSL K146
T173
DSQTKPWTRSTAPLY
0 1
pyrin (human) DAQGKPRtRSPALPG T177-p
pyrin (mouse) DSQTKPWTRSTAPLY T173
pyrin (rat) DSQTKPGARSAAPLY A173
S188-p
RRTQGTQsPGDKEST
0 2
pyrin (human) PALPGGRsPGPCRAL S187-p
pyrin (mouse) RRTQGTQsPGDKEST S188-p
pyrin (rat) RRTLVTQSPGDKENR S188
S205-p
AQLRRNVsSAGRLQG
Upstream
Downstream
8 3
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
Putative upstream phosphatases:
  • PPP2CA (human)
  • PPP2CB (human)
Treatment
  • bacterial infection
  • C. difficile Cytotoxin TcdA
  • calyculin_A
  • ciclosporin
  • Clostridioides difficile toxin B
  • Clostridium_toxin_B
  • okadaic_acid
  • siRNA
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pyrin (human) VRLRRNAssAGRLQG S208-p
pyrin (mouse) AQLRRNVsSAGRLQG S205-p
pyrin (rat) GAQPQECQLCREAAR Q204
S206
QLRRNVsSAGRLQGL
2 0
pyrin (human) RLRRNAssAGRLQGL S209-p
pyrin (mouse) QLRRNVsSAGRLQGL S206
pyrin (rat) AQPQECQLCREAARS L205
S223-p
NAPGRREsKKAEVYV
0 1
pyrin (human) GAPGQKECRPFEVYL C226
pyrin (mouse) NAPGRREsKKAEVYV S223-p
pyrin (rat) MSQGGERSRRLKCIC S222
S241-p
SGKKRPRsLEITTYS
Upstream
Downstream
8 7
Effects on Modified Protein
  • activity, inhibited
  • molecular association, regulation
Treatment
  • C. difficile Cytotoxin TcdA
  • Clostridium_toxin_B
pyrin (human) SGKMRPRsLEVTIST S242-p
pyrin (mouse) SGKKRPRsLEITTYS S241-p
pyrin (rat) QERSDPGVLKLPLTQ V238
E250
EITTYSREGEPPNSE
0 1
pyrin (human) EVTISTGEKAPANPE E251
pyrin (mouse) EITTYSREGEPPNSE E250
pyrin (rat) KLPLTQKkENPQIQK K247-ac
T303
SMVLDEKTFRNMSSK
0 1
pyrin (human) LLTLEEKtAANLDsA T267-p
pyrin (mouse) SMVLDEKTFRNMSSK T303
pyrin (rat) SMMLDEETSRNMSSK T299
S309
KTFRNMSSKTsLIGE
0 1
pyrin (human) KtAANLDsATEPRAR S273-p
pyrin (mouse) KTFRNMSSKTsLIGE S309
pyrin (rat) ETSRNMSSKISLTRE S305
S312-p
RNMSSKTsLIGEERC
0 1
pyrin (human) gap -
pyrin (mouse) RNMSSKTsLIGEERC S312-p
pyrin (rat) RNMSSKISLTREKRC S308
S432-p
QGLLARKsCEAQsPQ
0 2
pyrin (human) QDSHERKsPGSLsPQ S363-p
pyrin (mouse) QGLLARKsCEAQsPQ S432-p
pyrin (rat) QSSRAGKSCEAQSPQ S430
S437-p
RKsCEAQsPQSLPQC
0 2
pyrin (human) RKsPGSLsPQPLPQC S368-p
pyrin (mouse) RKsCEAQsPQSLPQC S437-p
pyrin (rat) GKSCEAQSPQFLPQC S435
K449
PQCPRHMKQVLLLFC
0 1
pyrin (human) PQCKRHLkQVQLLFC K380-ac
pyrin (mouse) PQCPRHMKQVLLLFC K449
pyrin (rat) PQCPRHMKQVQLLFC K447
R500
REQLERLREMRGYVE
0 1
pyrin (human) QKQLEHLkkLRKSGE K431-ac
pyrin (mouse) REQLERLREMRGYVE R500
pyrin (rat) RKQLERLREMRGYVE R498
E501
EQLERLREMRGYVEE
0 1
pyrin (human) KQLEHLkkLRKSGEE K432-ac
pyrin (mouse) EQLERLREMRGYVEE E501
pyrin (rat) KQLERLREMRGYVEE E499
T559-p
WLQELSQtISKVRET
Upstream
0 1
Regulatory protein:
  • RIPK3 (mouse)
pyrin (human) SLEDVGQMVGQIRKA M490
pyrin (mouse) WLQELSQtISKVRET T559-p
pyrin (rat) WLQELVQTIGKVRET T557
S640-p
EKNMQCFsEMLssEM
0 1
pyrin (human) EKSTKYFSETLRSEM S575
pyrin (mouse) EKNMQCFsEMLssEM S640-p
pyrin (rat) EKNMQRFSEMLGSEM S638
S644-p
QCFsEMLssEMAFSA
0 1
pyrin (human) KYFSETLRSEMEMFN R579
pyrin (mouse) QCFsEMLssEMAFSA S644-p
pyrin (rat) QRFSEMLGSEMAFSA G642
S645-p
CFsEMLssEMAFSAS
0 1
pyrin (human) YFSETLRSEMEMFNV S580
pyrin (mouse) CFsEMLssEMAFSAS S645-p
pyrin (rat) RFSEMLGSEMAFSAS S643
R751
RLRTCCYRDLDQAAA
0 1
pyrin (human) WILGACKtsISRKGN T672-p
pyrin (mouse) RLRTCCYRDLDQAAA R751
pyrin (rat) gap -
D752
LRTCCYRDLDQAAAH
0 1
pyrin (human) ILGACKtsISRKGNM S673-p
pyrin (mouse) LRTCCYRDLDQAAAH D752
pyrin (rat) gap -
-
gap
0 1
pyrin (human) RVGSISFyNVTARSH Y732-p
pyrin (mouse) gap -
pyrin (rat) gap -
-
gap
0 1
pyrin (human) VTARSHIyTFASCSF Y741-p
pyrin (mouse) gap -
pyrin (rat) gap -