Other Species / Isoforms
  pyrin (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S6-p
__MAKTPsDHLLstL
0 2
pyrin (human) __MAKTPsDHLLstL S6-p
pyrin (mouse) __MAKTLGDHLLNTL G6
pyrin (rat) __MANTRVDHLLNTL V6
S11-p
TPsDHLLstLEELVP
0 2
pyrin (human) TPsDHLLstLEELVP S11-p
pyrin (mouse) TLGDHLLNTLEELLP N11
pyrin (rat) TRVDHLLNTLEELLP N11
T12-p
PsDHLLstLEELVPY
0 2
pyrin (human) PsDHLLstLEELVPY T12-p
pyrin (mouse) LGDHLLNTLEELLPY T12
pyrin (rat) RVDHLLNTLEELLPY T12
S141-p
PYGGGAAsLRCSQPE
0 1
pyrin (human) PYGGGAAsLRCSQPE S141-p
pyrin (mouse) QNNDESDTLPSSQAE T136
pyrin (rat) QNDDESDILPPIQAE I136
R151-m1
CSQPEAGrGLSRKPL
0 1
pyrin (human) CSQPEAGrGLSRKPL R151-m1
pyrin (mouse) SSQAEVGKGPQKKSL K146
pyrin (rat) PIQAEVGKGPQKKSL K146
T177-p
DAQGKPRtRSPALPG
0 1
pyrin (human) DAQGKPRtRSPALPG T177-p
pyrin (mouse) DSQTKPWTRSTAPLY T173
pyrin (rat) DSQTKPGARSAAPLY A173
S187-p
PALPGGRsPGPCRAL
0 2
pyrin (human) PALPGGRsPGPCRAL S187-p
pyrin (mouse) RRTQGTQsPGDKEST S188-p
pyrin (rat) RRTLVTQSPGDKENR S188
S208-p
VRLRRNAssAGRLQG
Upstream
Downstream
8 3
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • PKN1 (human)
  • PKN2 (human)
Putative in vivo kinases:
  • PKN1 (human)
pyrin (human) VRLRRNAssAGRLQG S208-p
pyrin (mouse) AQLRRNVsSAGRLQG S205-p
pyrin (rat) GAQPQECQLCREAAR Q204
S209-p
RLRRNAssAGRLQGL
Downstream
2 0
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
pyrin (human) RLRRNAssAGRLQGL S209-p
pyrin (mouse) QLRRNVsSAGRLQGL S206
pyrin (rat) AQPQECQLCREAARS L205
C226
GAPGQKECRPFEVYL
0 1
pyrin (human) GAPGQKECRPFEVYL C226
pyrin (mouse) NAPGRREsKKAEVYV S223-p
pyrin (rat) MSQGGERSRRLKCIC S222
S242-p
SGKMRPRsLEVTIST
Upstream
Downstream
8 7
Effects on Modified Protein
  • activity, inhibited
  • intracellular localization
  • molecular association, regulation
Kinase, in vitro:
  • PKN1 (human)
  • PKN2 (human)
Putative in vivo kinases:
  • PKN1 (human)
Regulatory protein:
  • CDC42 (human)
Treatment
  • bacterial infection
  • C. difficile Cytotoxin TcdA
  • calyculin_A
  • Clostridioides difficile toxin B
  • etiocholanolone
  • IPA-3
  • LPS
  • pregnanolone
  • tautomycetin
  • UCN-01
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pyrin (human) SGKMRPRsLEVTIST S242-p
pyrin (mouse) SGKKRPRsLEITTYS S241-p
pyrin (rat) QERSDPGVLKLPLTQ V238
E251
EVTISTGEKAPANPE
0 1
pyrin (human) EVTISTGEKAPANPE E251
pyrin (mouse) EITTYSREGEPPNSE E250
pyrin (rat) KLPLTQKkENPQIQK K247-ac
T267-p
LLTLEEKtAANLDsA
0 1
pyrin (human) LLTLEEKtAANLDsA T267-p
pyrin (mouse) SMVLDEKTFRNMSSK T303
pyrin (rat) SMMLDEETSRNMSSK T299
S273-p
KtAANLDsATEPRAR
0 1
pyrin (human) KtAANLDsATEPRAR S273-p
pyrin (mouse) KTFRNMSSKTsLIGE S309
pyrin (rat) ETSRNMSSKISLTRE S305
-
gap
0 1
pyrin (human) gap -
pyrin (mouse) RNMSSKTsLIGEERC S312-p
pyrin (rat) RNMSSKISLTREKRC S308
S363-p
QDSHERKsPGSLsPQ
0 2
pyrin (human) QDSHERKsPGSLsPQ S363-p
pyrin (mouse) QGLLARKsCEAQsPQ S432-p
pyrin (rat) QSSRAGKSCEAQSPQ S430
S368-p
RKsPGSLsPQPLPQC
0 2
pyrin (human) RKsPGSLsPQPLPQC S368-p
pyrin (mouse) RKsCEAQsPQSLPQC S437-p
pyrin (rat) GKSCEAQSPQFLPQC S435
K380-ac
PQCKRHLkQVQLLFC
0 1
pyrin (human) PQCKRHLkQVQLLFC K380-ac
pyrin (mouse) PQCPRHMKQVLLLFC K449
pyrin (rat) PQCPRHMKQVQLLFC K447
K431-ac
QKQLEHLkkLRKSGE
0 1
pyrin (human) QKQLEHLkkLRKSGE K431-ac
pyrin (mouse) REQLERLREMRGYVE R500
pyrin (rat) RKQLERLREMRGYVE R498
K432-ac
KQLEHLkkLRKSGEE
0 1
pyrin (human) KQLEHLkkLRKSGEE K432-ac
pyrin (mouse) EQLERLREMRGYVEE E501
pyrin (rat) KQLERLREMRGYVEE E499
M490
SLEDVGQMVGQIRKA
0 1
pyrin (human) SLEDVGQMVGQIRKA M490
pyrin (mouse) WLQELSQtISKVRET T559-p
pyrin (rat) WLQELVQTIGKVRET T557
S575
EKSTKYFSETLRSEM
0 1
pyrin (human) EKSTKYFSETLRSEM S575
pyrin (mouse) EKNMQCFsEMLssEM S640-p
pyrin (rat) EKNMQRFSEMLGSEM S638
R579
KYFSETLRSEMEMFN
0 1
pyrin (human) KYFSETLRSEMEMFN R579
pyrin (mouse) QCFsEMLssEMAFSA S644-p
pyrin (rat) QRFSEMLGSEMAFSA G642
S580
YFSETLRSEMEMFNV
0 1
pyrin (human) YFSETLRSEMEMFNV S580
pyrin (mouse) CFsEMLssEMAFSAS S645-p
pyrin (rat) RFSEMLGSEMAFSAS S643
T672-p
WILGACKtsISRKGN
0 1
pyrin (human) WILGACKtsISRKGN T672-p
pyrin (mouse) RLRTCCYRDLDQAAA R751
pyrin (rat) gap -
S673-p
ILGACKtsISRKGNM
0 1
pyrin (human) ILGACKtsISRKGNM S673-p
pyrin (mouse) LRTCCYRDLDQAAAH D752
pyrin (rat) gap -
Y732-p
RVGSISFyNVTARSH
0 1
pyrin (human) RVGSISFyNVTARSH Y732-p
pyrin (mouse) gap -
pyrin (rat) gap -
Y741-p
VTARSHIyTFASCSF
0 1
pyrin (human) VTARSHIyTFASCSF Y741-p
pyrin (mouse) gap -
pyrin (rat) gap -