Other Species / Isoforms
  ERK5 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K6
__MAEPLKEEDGEDG
3 0
ERK5 (human) __MAEPLKEEDGEDG K6
ERK5 iso2 (human) gap -
ERK5 (mouse) __MAEPLkEEDGEDG K6-sm
ERK5 (rat) __MAEPLKEEDGEDG K6
S14-p
EEDGEDGsAEPPGPV
0 1
ERK5 (human) EEDGEDGsAEPPGPV S14-p
ERK5 iso2 (human) gap -
ERK5 (mouse) EEDGEDGSGEPPGRV S14
ERK5 (rat) EEDGEDGSGEPPGRV S14
K22
AEPPGPVKAEPAHtA
3 0
ERK5 (human) AEPPGPVKAEPAHtA K22
ERK5 iso2 (human) gap -
ERK5 (mouse) GEPPGRVkAEPVHTA K22-sm
ERK5 (rat) GEPPGRVKAEPVHTA K22
T28-p
VKAEPAHtAAsVAAk
Upstream
1 0
Kinase, in vitro:
  • ERK5 (human)
ERK5 (human) VKAEPAHtAAsVAAk T28-p
ERK5 iso2 (human) gap -
ERK5 (mouse) VkAEPVHTAASVVAK T28
ERK5 (rat) VKAEPVHTAASVVAK T28
S31-p
EPAHtAAsVAAkNLA
0 1
ERK5 (human) EPAHtAAsVAAkNLA S31-p
ERK5 iso2 (human) gap -
ERK5 (mouse) EPVHTAASVVAKNLA S31
ERK5 (rat) EPVHTAASVVAKNLA S31
K35-ac
tAAsVAAkNLALLKA
Upstream
0 2
Treatment
  • MS275
  • vorinostat
ERK5 (human) tAAsVAAkNLALLKA K35-ac
ERK5 iso2 (human) gap -
ERK5 (mouse) TAASVVAKNLALLKA K35
ERK5 (rat) TAASVVAKNLALLKA K35
S70-p
NGAYGVVssARRRLT
0 1
ERK5 (human) NGAYGVVssARRRLT S70-p
ERK5 iso2 (human) gap -
ERK5 (mouse) NGAYGVVSSARRRLT S70
ERK5 (rat) NGAYGVVSSARRRLT S70
S71-p
GAYGVVssARRRLTG
0 1
ERK5 (human) GAYGVVssARRRLTG S71-p
ERK5 iso2 (human) gap -
ERK5 (mouse) GAYGVVSSARRRLTG S71
ERK5 (rat) GAYGVVSSARRRLTG S71
K184-ub
QVIHRDLkPSNLLVN
1 0
ERK5 (human) QVIHRDLkPSNLLVN K184-ub
ERK5 iso2 (human) QVIHRDLKPSNLLVN K45
ERK5 (mouse) QVIHRDLKPSNLLVN K184
ERK5 (rat) QVIHRDLKPSNLLVN K184
Y216-p
TSPAEHQyFMtEyVA
0 2
ERK5 (human) TSPAEHQyFMtEyVA Y216-p
ERK5 iso2 (human) TSPAEHQYFMTEYVA Y77
ERK5 (mouse) TSPAEHQYFMtEyVA Y216
ERK5 (rat) TSPAEHQYFMtEyVA Y216
T219-p
AEHQyFMtEyVAtRW
Upstream
Downstream
15 33
ERK5 (human)
T219-p
ERK5 (mouse)
T219-p
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • MEK5 (human)
Regulatory protein:
  • BRAF (human)
  • Brk (human)
  • MEK5 (human)
  • PDGFRB (human)
  • PTP-SL (human)
  • WNK1 (human)
  • WNK2 (human)
Treatment
  • CTGF
  • DAPH
  • EGF
  • FGF2
  • K252a
  • LY294002
  • neuregulin
  • nocodazole
  • PDGF
  • phorbol_ester
  • siRNA
  • sorbitol
  • SU6656
  • U0126
ERK5 (human) AEHQyFMtEyVAtRW T219-p
ERK5 iso2 (human) AEHQYFMTEYVATRW T80
ERK5 (mouse) AEHQYFMtEyVAtRW T219-p
ERK5 (rat) AEHQYFMtEyVATRW T219-p
Y221-p
HQyFMtEyVAtRWYR
Upstream
Downstream
15 980
ERK5 (mouse)
Y221-p
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • MEK5 (human)
Regulatory protein:
  • BRAF (human)
  • Brk (human)
  • EGFR (human)
  • MEK5 (human)
  • PDGFRB (human)
  • PTP-SL (human)
  • WNK1 (human)
  • WNK2 (human)
Treatment
  • CTGF
  • DAPH
  • EGF
  • FGF2
  • HGF
  • IL-15
  • IL-2
  • K252a
  • LY294002
  • neuregulin
  • nocodazole
  • PDGF
  • phorbol_ester
  • siRNA
  • sorbitol
  • SU6656
  • U0126
ERK5 (human) HQyFMtEyVAtRWYR Y221-p
ERK5 iso2 (human) HQYFMTEYVATRWYR Y82
ERK5 (mouse) HQYFMtEyVAtRWYR Y221-p
ERK5 (rat) HQYFMtEyVATRWYR Y221-p
T224-p
FMtEyVAtRWYRAPE
0 2
ERK5 (human) FMtEyVAtRWYRAPE T224-p
ERK5 iso2 (human) FMTEYVATRWYRAPE T85
ERK5 (mouse) FMtEyVAtRWYRAPE T224-p
ERK5 (rat) FMtEyVATRWYRAPE T224
T280-p
LIMMVLGtPsPAVIQ
0 1
ERK5 (human) LIMMVLGtPsPAVIQ T280-p
ERK5 iso2 (human) LIMMVLGTPSPAVIQ T141
ERK5 (mouse) LIMMVLGTPSPAVIQ T280
ERK5 (rat) LIMMVLGTPSPAVIQ T280
S282-p
MMVLGtPsPAVIQAV
0 1
ERK5 (human) MMVLGtPsPAVIQAV S282-p
ERK5 iso2 (human) MMVLGTPSPAVIQAV S143
ERK5 (mouse) MMVLGTPSPAVIQAV S282
ERK5 (rat) MMVLGTPSPAVIQAV S282
S322-p
GADRQALsLLGRMLR
0 2
ERK5 (human) GADRQALsLLGRMLR S322-p
ERK5 iso2 (human) GADRQALSLLGRMLR S183
ERK5 (mouse) GADRQALsLLGRMLR S322-p
ERK5 (rat) GADRQALSLLGRMLR S322
K378-ub
ALTRERIkEAIVAEI
0 1
ERK5 (human) ALTRERIkEAIVAEI K378-ub
ERK5 iso2 (human) ALTRERIKEAIVAEI K239
ERK5 (mouse) ALTRERIKEAIVAEI K378
ERK5 (rat) ALTRERIKEAIVAEI K378
S421-p
CPDVEMPsPWAPSGD
Upstream
2 1
Kinase, in vitro:
  • ERK5 (human)
ERK5 (human) CPDVEMPsPWAPSGD S421-p
ERK5 iso2 (human) CPDVEMPSPWAPSGD S282
ERK5 (mouse) CPDVEMPsPWAPSGD S421-p
ERK5 (rat) CPDVEMPSPWAPSGD S421
S433-p
SGDCAMEsPPPAPPP
Upstream
2 1
Kinase, in vitro:
  • ERK5 (human)
ERK5 (human) SGDCAMEsPPPAPPP S433-p
ERK5 iso2 (human) SGDCAMESPPPAPPP S294
ERK5 (mouse) SGDCAMEsPPPALPP S433-p
ERK5 (rat) SGDCAMESPPPALPP S433
S472-p
PKKDGAIsDNTKAAL
0 1
ERK5 (human) PKKDGAIsDNTKAAL S472-p
ERK5 iso2 (human) PKKDGAISDNTKAAL S333
ERK5 (mouse) PKREGAISDNTKAAL S472
ERK5 (rat) PKREGAISDNTKAAL S472
K480-m1
DNTKAALkAALLksL
0 1
ERK5 (human) DNTKAALkAALLksL K480-m1
ERK5 iso2 (human) DNTKAALKAALLKSL K341
ERK5 (mouse) DNTKAALKAALLKsL K480
ERK5 (rat) DNTKAALKAALLKSL K480
K485-m1
ALkAALLksLRSRLR
0 1
ERK5 (human) ALkAALLksLRSRLR K485-m1
ERK5 iso2 (human) ALKAALLKSLRSRLR K346
ERK5 (mouse) ALKAALLKsLRSRLR K485
ERK5 (rat) ALKAALLKSLRSRLR K485
S486-p
LkAALLksLRSRLRD
Upstream
2 4
Treatment
  • ischemia
  • LRRK2-IN-1
ERK5 (human) LkAALLksLRSRLRD S486-p
ERK5 iso2 (human) LKAALLKSLRSRLRD S347
ERK5 (mouse) LKAALLKsLRSRLRD S486-p
ERK5 (rat) LKAALLKSLRSRLRD S486
S496-p
SRLRDGPsAPLEAPE
Upstream
7 1
Kinase, in vitro:
  • ERK5 (human)
Putative in vivo kinases:
  • p90RSK (human)
ERK5 (human) SRLRDGPsAPLEAPE S496-p
ERK5 iso2 (human) SRLRDGPSAPLEAPE S357
ERK5 (mouse) SRLRDGPsAPLEAPE S496-p
ERK5 (rat) SRLRDGPSAPLEAPE S496
S562-p
PLAGLVLsDNDRsLL
0 1
ERK5 (human) PLAGLVLsDNDRsLL S562-p
ERK5 iso2 (human) PLAGLVLSDNDRSLL S423
ERK5 (mouse) PLAGLVLSDNDRSLL S562
ERK5 (rat) PLAGLVLSDNDRSLL S562
S567-p
VLsDNDRsLLERWTR
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Treatment
  • nocodazole
  • sorbitol
ERK5 (human) VLsDNDRsLLERWTR S567-p
ERK5 iso2 (human) VLSDNDRSLLERWTR S428
ERK5 (mouse) VLSDNDRSLLERWTR S567
ERK5 (rat) VLSDNDRSLLERWTR S567
T584-p
RPAAPALtSVPAPAP
0 1
ERK5 (human) RPAAPALtSVPAPAP T584-p
ERK5 iso2 (human) RPAAPALTSVPAPAP T445
ERK5 (mouse) gap -
ERK5 (rat) gap -
S707-p
PQSSMSEsPDVNLVT
0 1
ERK5 (human) PQSSMSEsPDVNLVT S707-p
ERK5 iso2 (human) PQSSMSESPDVNLVT S568
ERK5 (mouse) PQPSTSESPDVNLVT S697
ERK5 (rat) PQPSTSESPDVNLVT S697
S718-p
NLVTQQLsKsQVEDP
0 1
ERK5 (human) NLVTQQLsKsQVEDP S718-p
ERK5 iso2 (human) NLVTQQLSKSQVEDP S579
ERK5 (mouse) NLVTQQLSKSQVEDP S708
ERK5 (rat) NLVTQQLSKSQVEDP S708
S720-p
VTQQLsKsQVEDPLP
Upstream
Downstream
1 6
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Treatment
  • nocodazole
  • sorbitol
ERK5 (human) VTQQLsKsQVEDPLP S720-p
ERK5 iso2 (human) VTQQLSKSQVEDPLP S581
ERK5 (mouse) VTQQLSKSQVEDPLP S710
ERK5 (rat) VTQQLSKSQVEDPLP S710
S731-p
DPLPPVFsGtPKGSG
Upstream
Downstream
4 11
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • ERK5 (human)
Treatment
  • EGF
  • ischemia
  • nocodazole
  • SB202190
  • sorbitol
  • U0126
ERK5 (human) DPLPPVFsGtPKGSG S731-p
ERK5 iso2 (human) DPLPPVFSGTPKGSG S592
ERK5 (mouse) DPLPPVFsGtPKGSG S721-p
ERK5 (rat) DPLPPVFSGTPKGSG S721
T733-p
LPPVFsGtPKGSGAG
Upstream
Downstream
6 14
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • ERK5 (human)
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
  • ERK5 (human)
Regulatory protein:
  • BRAF (human)
  • MEK5 (human)
Treatment
  • EGF
  • ischemia
  • NGF
  • nocodazole
  • RO-3306
  • SB202190
  • SCH772984
  • sorbitol
  • U0126
ERK5 (human) LPPVFsGtPKGSGAG T733-p
ERK5 iso2 (human) LPPVFSGTPKGSGAG T594
ERK5 (mouse) LPPVFsGtPKGSGAG T723-p
ERK5 (rat) LPPVFSGTPKGSGAG T723
S754-p
LEEFLNQsFDMGVAD
Upstream
Downstream
1 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, induced
Regulatory protein:
  • BRAF (human)
Treatment
  • RO-3306
  • SCH772984
ERK5 (human) LEEFLNQsFDMGVAD S754-p
ERK5 iso2 (human) LEEFLNQSFDMGVAD S615
ERK5 (mouse) LEEFLNQSFDMGVAD S744
ERK5 (rat) LEEFLNQSFDMGVAD S744
S770-p
PQDGQADsAsLsAsL
Upstream
2 1
Putative in vivo kinases:
  • ERK5 (human)
ERK5 (human) PQDGQADsAsLsAsL S770-p
ERK5 iso2 (human) PQDGQADSASLSASL S631
ERK5 (mouse) PQDGQADsASLsAsL S760-p
ERK5 (rat) PQDGQADSASLSASL S760
S772-p
DGQADsAsLsAsLLA
Upstream
1 1
Putative in vivo kinases:
  • ERK5 (human)
ERK5 (human) DGQADsAsLsAsLLA S772-p
ERK5 iso2 (human) DGQADSASLSASLLA S633
ERK5 (mouse) DGQADsASLsAsLLA S762
ERK5 (rat) DGQADSASLSASLLA S762
S774-p
QADsAsLsAsLLADW
Upstream
2 1
Putative in vivo kinases:
  • ERK5 (human)
ERK5 (human) QADsAsLsAsLLADW S774-p
ERK5 iso2 (human) QADSASLSASLLADW S635
ERK5 (mouse) QADsASLsAsLLADW S764-p
ERK5 (rat) QADSASLSASLLADW S764
S776-p
DsAsLsAsLLADWLE
1 1
ERK5 (human) DsAsLsAsLLADWLE S776-p
ERK5 iso2 (human) DSASLSASLLADWLE S637
ERK5 (mouse) DsASLsAsLLADWLE S766-p
ERK5 (rat) DSASLSASLLADWLE S766
S803-p
QREIQMDsPMLLADL
Upstream
Downstream
1 4
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Treatment
  • nocodazole
  • sorbitol
ERK5 (human) QREIQMDsPMLLADL S803-p
ERK5 iso2 (human) QREIQMDSPMLLADL S664
ERK5 (mouse) QREIQMDSPMLLSDL S793
ERK5 (rat) QREIQMDSPMLLSDL S793