Other Species / Isoforms
  H3 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
R2-m1
______ArtkQtArk
Upstream
1 0
Regulatory protein:
  • RNF168 (human)
Treatment
  • EPZ015666
  • MTDIA
H3 (human) ______ArtkQtArk R2-m1
H3 (mouse) ______ARtkQTARk R2
H3 iso2 (mouse) ______ARTkQTARk R2
H3 iso3 (mouse) ______ARtKQTARk R2
H3 (rat) ______ARtkQTARk R2
H3 iso3 (rat) ______ARTkQTARk R2
H3 (pig) ______ARTkQTARk R2
H3 (chicken) ______ARTkQTARk R2
H3 (cow) ______ARTkQTARk R2
R2-m2
______ArtkQtArk
Upstream
Downstream
6 0
H3 (human)
R2-m2
H3 (mouse)
R2-m2
H3 iso2 (mouse)
R2-m2
H3 iso3 (mouse)
R2-m2
H3 (rat)
R2-m2
H3 iso3 (rat)
R2-m2
H3 (pig)
R2-m2
H3 (chicken)
R2-m2
H3 (cow)
R2-m2
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • camptothecin
  • H2O2
  • ionizing_radiation
  • MMS
  • phleomycin
  • PRMT6 inhibitor
  • UV
H3 (human) ______ArtkQtArk R2-m2
H3 (mouse) ______ARtkQTARk R2
H3 iso2 (mouse) ______ARTkQTARk R2
H3 iso3 (mouse) ______ARtKQTARk R2
H3 (rat) ______ARtkQTARk R2
H3 iso3 (rat) ______ARTkQTARk R2
H3 (pig) ______ARTkQTARk R2
H3 (chicken) ______ARTkQTARk R2
H3 (cow) ______ARTkQTARk R2
T3-p
_____ArtkQtArks
Upstream
Downstream
24 2
H3 (human)
T3-p
H3 (mouse)
T3-p
H3 iso2 (mouse)
T3-p
H3 iso3 (mouse)
T3-p
H3 (rat)
T3-p
H3 iso3 (rat)
T3-p
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • chromatin organization, altered
  • cytoskeletal reorganization
  • signaling pathway regulation
  • transcription, inhibited
Kinase, in vitro:
  • ChaK2 (human)
  • Haspin (human)
  • VRK1 (human)
Putative in vivo kinases:
  • AurB (human)
  • Haspin (human)
  • VRK1 (human)
Regulatory protein:
  • AurB (human)
  • CDCA2 (human)
  • PPP1R14A (human)
Treatment
  • CHR-6494
  • MG132
  • nocodazole
  • siRNA
  • ZM447439
H3 (human) _____ArtkQtArks T3-p
H3 (mouse) _____ARtkQTARks T3-p
H3 iso2 (mouse) _____ARTkQTARks T3
H3 iso3 (mouse) _____ARtKQTARks T3-p
H3 (rat) _____ARtkQTARks T3-p
H3 iso3 (rat) _____ARTkQTARks T3
H3 (pig) _____ARTkQTARkS T3
H3 (chicken) _____ARTkQTARks T3
H3 (cow) _____ARTkQTARkS T3
K4-ac
____ArtkQtArkst
Upstream
Downstream
15 11
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • signaling pathway regulation
  • transcription, induced
Regulatory protein:
  • WNT3A (human)
Treatment
  • 5-aza-CdR
  • bacterial infection
  • CIL-102
  • EGF
  • FH535
  • LPS
  • LY294002
  • niraparib
  • romidepsin
  • TGF-beta
  • trichostatin_A
  • valproic acid
H3 (human) ____ArtkQtArkst K4-ac
H3 (mouse) ____ARtkQTARkst K4-ac
H3 iso2 (mouse) ____ARTKQTARksT K4
H3 iso3 (mouse) ____ARtKQTARksT K4
H3 (rat) ____ARtkQTARkst K4-ac
H3 iso3 (rat) ____ARTKQTARksT K4
H3 (pig) ____ARTKQTARkST K4
H3 (chicken) ____ARTKQTARksT K4
H3 (cow) ____ARTKQTARkST K4
K4-me
____ArtkQtArkst
Upstream
Downstream
29 1
Effects on Modified Protein
  • acetylation
  • intracellular localization
  • methylation
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell differentiation, induced
  • cell growth, induced
  • cell motility, induced
  • chromatin organization, altered
  • transcription, altered
  • transcription, induced
Regulatory protein:
  • HDAC1 (human)
  • HDAC2 (human)
  • HDAC3 (human)
  • HDAC6 (human)
  • HDAC8 (human)
  • JMJD3 (human)
  • KANSL3 (human)
  • STAT4 (human)
Treatment
  • AR42
  • AzaC
  • heating
  • IL-12
  • KNK437
  • LPS
  • MS275
  • mutation
  • PUGNAc
  • retinoic_acid
  • siRNA
  • trichostatin_A
  • vorinostat
H3 (human) ____ArtkQtArkst K4-me
H3 (mouse) ____ARtkQTARkst K4-me
H3 iso2 (mouse) ____ARTKQTARksT K4
H3 iso3 (mouse) ____ARtKQTARksT K4
H3 (rat) ____ARtKQTARkst K4
H3 iso3 (rat) ____ARTKQTARksT K4
H3 (pig) ____ARTKQTARkST K4
H3 (chicken) ____ARTKQTARksT K4
H3 (cow) ____ARTKQTARkST K4
K4-m1
____ArtkQtArkst
Upstream
Downstream
43 19
H3 (human)
K4-m1
H3 (mouse)
K4-m1
H3 iso2 (mouse)
K4-m1
H3 iso3 (mouse)
K4-m1
H3 (rat)
K4-m1
H3 iso3 (rat)
K4-m1
H3 (pig)
K4-m1
H3 (chicken)
K4-m1
H3 (cow)
K4-m1
Effects on Modified Protein
  • acetylation
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, inhibited
  • chromatin organization, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • ASH2L (human)
  • FOXA1 (human)
  • H2B (human)
  • HBB (human)
  • LSD1 (human)
  • Myc (human)
  • RBBP5 (human)
  • SETD7 (human)
  • WDR5 (human)
Treatment
  • AEBSF
  • androstanolone
  • dexamethasone
  • H-Leu-Leu-OMe
  • IFN-gamma
  • nafamostat
  • pargyline
  • PD98059
  • siRNA
  • staurosporine
  • TNF
  • UNC0638
  • UNC1999
H3 (human) ____ArtkQtArkst K4-m1
H3 (mouse) ____ARtkQTARkst K4-m1
H3 iso2 (mouse) ____ARTkQTARksT K4-m1
H3 iso3 (mouse) ____ARtKQTARksT K4
H3 (rat) ____ARtKQTARkst K4
H3 iso3 (rat) ____ARTKQTARksT K4
H3 (pig) ____ARTKQTARkST K4
H3 (chicken) ____ARTKQTARksT K4
H3 (cow) ____ARTKQTARkST K4
K4-m2
____ArtkQtArkst
Upstream
Downstream
105 10
H3 (human)
K4-m2
H3 (mouse)
K4-m2
H3 iso2 (mouse)
K4-m2
H3 iso3 (mouse)
K4-m2
H3 (rat)
K4-m2
H3 iso3 (rat)
K4-m2
Effects on Modified Protein
  • acetylation
  • intracellular localization
  • methylation
  • molecular association, regulation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, induced
  • cell growth, inhibited
  • chromatin organization, altered
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • ASH2L (human)
  • FOXA1 (human)
  • H1D (human)
  • H2A.1 (human)
  • H2B (human)
  • H4 (human)
  • HBB (human)
  • HDAC1 (human)
  • HDAC2 (human)
  • HDAC3 (human)
  • HDAC6 (human)
  • HDAC8 (human)
  • HMG20A (human)
  • KANSL3 (human)
  • LSD1 (human)
  • MTA1 (human)
  • Myb (human)
  • Myc (human)
  • MYST1 (human)
  • OGT (human)
  • PHF8 (human)
  • RBBP5 (human)
  • RNF20 (human)
  • RNF40 (human)
  • SAFB1 (human)
  • WDR5 (human)
Treatment
  • 5'-methylthioadenosine
  • 5-aza-CdR
  • androstanolone
  • AR42
  • dexamethasone
  • genistein
  • GSK467
  • liothyronine
  • LPS
  • MS275
  • pargyline
  • PD98059
  • retinoic_acid
  • S2101
  • siRNA
  • trichostatin_A
  • vorinostat
H3 (human) ____ArtkQtArkst K4-m2
H3 (mouse) ____ARtkQTARkst K4-m2
H3 iso2 (mouse) ____ARTkQTARksT K4-m2
H3 iso3 (mouse) ____ARtKQTARksT K4
H3 (rat) ____ARtkQTARkst K4-m2
H3 iso3 (rat) ____ARTKQTARksT K4
H3 (pig) ____ARTKQTARkST K4
H3 (chicken) ____ARTkQTARksT K4-m2
H3 (cow) ____ARTKQTARkST K4
K4-m3
____ArtkQtArkst
Upstream
Downstream
172 10
H3 (human)
K4-m3
H3 (mouse)
K4-m3
H3 iso2 (mouse)
K4-m3
H3 iso3 (mouse)
K4-m3
H3 (rat)
K4-m3
H3 iso3 (rat)
K4-m3
Effects on Modified Protein
  • acetylation
  • intracellular localization
  • methylation
  • molecular association, regulation
  • ubiquitination
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, induced
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, induced
  • cell growth, inhibited
  • cell motility, induced
  • chromatin organization, altered
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • ABHD5 (human)
  • AP-2 delta (mouse)
  • ASH2L (human)
  • ASXL1 (human)
  • DNMT1 (human)
  • DNMT3B (human)
  • GLDC (human)
  • H2B (human)
  • HBB (human)
  • HDAC1 (human)
  • HDAC2 (human)
  • HDAC3 (human)
  • HDAC6 (human)
  • HDAC8 (human)
  • HMG20A (human)
  • KANSL3 (human)
  • LSD1 (human)
  • MEN1 (human)
  • MLLT3 (human)
  • MTHFR (human)
  • Myb (human)
  • Myc (human)
  • PAXIP1 (human)
  • PC4 (human)
  • PHF8 (human)
  • RBBP5 (human)
  • RNF20 (human)
  • RNF40 (human)
  • SETDB1 (human)
  • SETDB2 (human)
  • TET2 (human)
  • TET3 (human)
  • TRRAP (human)
  • UHRF1 (human)
  • WDR5 (human)
Treatment
  • 17-beta-estradiol
  • 5'-methylthioadenosine
  • 5-aza-CdR
  • alloxan
  • alpelisib
  • ambient air polution
  • amino_acid_starvation
  • AR42
  • AZD6482
  • butyrate
  • CoCl2
  • D9
  • dabrafenib
  • depsipeptide
  • dexamethasone
  • docetaxel
  • etoposide
  • FIDAS-5
  • formate
  • genistein
  • glucose_starvation
  • GnRH
  • GSK467
  • histidinol
  • homocysteine
  • hypoxia
  • IFN-gamma
  • liothyronine
  • LLY-507
  • methionine-deficient medium
  • MK-2206
  • MS275
  • NM-PP1
  • PBIT
  • PD98059
  • pictilisib
  • PTC-209
  • rapamycin
  • retinoic_acid
  • SAM
  • siRNA
  • Trametinib
  • trichostatin_A
  • vorinostat
H3 (human) ____ArtkQtArkst K4-m3
H3 (mouse) ____ARtkQTARkst K4-m3
H3 iso2 (mouse) ____ARTKQTARksT K4
H3 iso3 (mouse) ____ARtKQTARksT K4
H3 (rat) ____ARtkQTARkst K4-m3
H3 iso3 (rat) ____ARTkQTARksT K4-m3
H3 (pig) ____ARTkQTARkST K4-m3
H3 (chicken) ____ARTkQTARksT K4-m3
H3 (cow) ____ARTkQTARkST K4-m3
K4-ub
____ArtkQtArkst
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • chromatin organization, altered
  • transcription, induced
Treatment
  • EGF
H3 (human) ____ArtkQtArkst K4-ub
H3 (mouse) ____ARtKQTARkst K4
H3 iso2 (mouse) ____ARTKQTARksT K4
H3 iso3 (mouse) ____ARtKQTARksT K4
H3 (rat) ____ARtKQTARkst K4
H3 iso3 (rat) ____ARTKQTARksT K4
H3 (pig) ____ARTKQTARkST K4
H3 (chicken) ____ARTKQTARksT K4
H3 (cow) ____ARTKQTARkST K4
T6-p
__ArtkQtArkstGG
Upstream
Downstream
5 2
Effects on Modified Protein
  • methylation
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
  • transcription, induced
Kinase, in vitro:
  • ChaK2 (human)
  • PKCB (human)
Putative in vivo kinases:
  • PKCA (human)
  • PKCB (human)
Treatment
  • androstanolone
  • arcyriarubin_A
  • bisindolylmaleimide
  • siRNA
H3 (human) __ArtkQtArkstGG T6-p
H3 (mouse) __ARtkQTARkstGG T6
H3 iso2 (mouse) __ARTkQTARksTGG T6
H3 iso3 (mouse) __ARtKQTARksTGG T6
H3 (rat) __ARtkQTARkstGG T6
H3 iso3 (rat) __ARTkQTARksTGG T6
H3 (pig) __ARTkQTARkSTGG T6
H3 (chicken) __ARTkQTARksTGG T6
H3 (cow) __ARTkQTARkSTGG T6
R8-me
ArtkQtArkstGGkA
Downstream
1 0
Effects on Modified Protein
  • acetylation
H3 (human) ArtkQtArkstGGkA R8-me
H3 (mouse) ARtkQTARkstGGkA R8
H3 iso2 (mouse) ARTkQTARksTGGkA R8
H3 iso3 (mouse) ARtKQTARksTGGkA R8
H3 (rat) ARtkQTARkstGGkA R8
H3 iso3 (rat) ARTkQTARksTGGkA R8
H3 (pig) ARTkQTARkSTGGkA R8
H3 (chicken) ARTkQTARksTGGkA R8
H3 (cow) ARTkQTARkSTGGKA R8
R8-m2
ArtkQtArkstGGkA
Upstream
Downstream
4 1
H3 (human)
R8-m2
H3 (mouse)
R8-m2
H3 iso2 (mouse)
R8-m2
H3 iso3 (mouse)
R8-m2
H3 (rat)
R8-m2
H3 iso3 (rat)
R8-m2
H3 (pig)
R8-m2
H3 (chicken)
R8-m2
H3 (cow)
R8-m2
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
Regulatory protein:
  • PRMT5 (human)
  • RNF168 (human)
Treatment
  • EPZ015666
  • MTDIA
H3 (human) ArtkQtArkstGGkA R8-m2
H3 (mouse) ARtkQTARkstGGkA R8
H3 iso2 (mouse) ARTkQTARksTGGkA R8
H3 iso3 (mouse) ARtKQTARksTGGkA R8
H3 (rat) ARtkQTARkstGGkA R8
H3 iso3 (rat) ARTkQTARksTGGkA R8
H3 (pig) ARTkQTARkSTGGkA R8
H3 (chicken) ARTkQTARksTGGkA R8
H3 (cow) ARTkQTARkSTGGKA R8
K9-ac
rtkQtArkstGGkAP
Upstream
Downstream
200 366
H3 (human)
K9-ac
H3 (mouse)
K9-ac
H3 iso2 (mouse)
K9-ac
H3 iso3 (mouse)
K9-ac
H3 (rat)
K9-ac
H3 iso3 (rat)
K9-ac
H3 (pig)
K9-ac
H3 (chicken)
K9-ac
H3 (cow)
K9-ac
Effects on Modified Protein
  • acetylation
  • enzymatic activity, induced
  • intracellular localization
  • methylation
  • molecular association, regulation
  • protein degradation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, induced
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell differentiation, induced
  • cell growth, induced
  • cell growth, inhibited
  • chromatin organization, altered
  • neural plasticity
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • AMPKA1 (human)
  • CtIP (human)
  • E2F1 (human)
  • EHMT2 (human)
  • FXR1 (human)
  • H2AX (human)
  • HAT1 (human)
  • HDAC1 (human)
  • HDAC2 (human)
  • HMGN1 (human)
  • MBD3 (human)
  • Myb (human)
  • Myc (human)
  • MYST1 (human)
  • NFkB-p65 (human)
  • OGT (human)
  • p53 (human)
  • PC4 (human)
  • PHF8 (human)
  • PKN1 (human)
  • PRMT1 (mouse)
  • PRMT5 (human)
  • RGC32 (human)
  • SIRT6 (human)
  • SMARCA2 (human)
  • SMARCA4 (human)
  • SUV39H1 (human)
  • TCF7L2 (human)
  • TRRAP (human)
  • ZNF263 (human)
Treatment
  • 5-aza-CdR
  • A-485
  • A23187
  • acadesine
  • acetate
  • acidosis
  • AzaC
  • bacterial infection
  • BIX01294
  • BMS-3031
  • BMX
  • bortezomib
  • butyrate
  • C646
  • C8 MCT Oil Supplement
  • camptothecin
  • CDCA
  • ciglitazone
  • compound 1
  • compound 2
  • compound_3
  • compound_8
  • DCA
  • DDATHF
  • depsipeptide
  • dexamethasone
  • DRB
  • DTBR
  • estradiol
  • etoposide
  • exercise
  • glucose
  • glucose_starvation
  • gold nanoparticles
  • H2O2
  • hemorrhage
  • hypertonic_buffer
  • ionizing_radiation
  • KU-55933
  • lactated Ringer’s
  • LBH-589
  • liothyronine
  • LPS
  • LY294002
  • medium change
  • metribolone
  • MMS
  • MS275
  • NaB
  • nicotinamide
  • PD98059
  • phleomycin
  • phorbol_ester
  • plumbagin
  • PXD101
  • retinoic_acid
  • Ro31-8220
  • selisistat
  • siRNA
  • SP600125
  • TGF-beta
  • TMZ
  • TNF
  • trichostatin_A
  • troglitazone
  • UK5099
  • UNC0638
  • UV
  • valproic acid
  • vorinostat
  • wortmannin
  • zymosan
H3 (human) rtkQtArkstGGkAP K9-ac
H3 (mouse) RtkQTARkstGGkAP K9-ac
H3 iso2 (mouse) RTkQTARksTGGkAP K9-ac
H3 iso3 (mouse) RtKQTARksTGGkAP K9-ac
H3 (rat) RtkQTARkstGGkAP K9-ac
H3 iso3 (rat) RTkQTARksTGGkAP K9-ac
H3 (pig) RTkQTARkSTGGkAP K9-ac
H3 (chicken) RTkQTARksTGGkAP K9-ac
H3 (cow) RTkQTARkSTGGKAP K9-ac
K9-me
rtkQtArkstGGkAP
Upstream
Downstream
27 1
Effects on Modified Protein
  • acetylation
  • intracellular localization
  • methylation
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • chromatin organization, altered
  • transcription, altered
  • transcription, inhibited
Regulatory protein:
  • GLP-1 (human)
  • NFkB-p65 (human)
  • p300 (human)
Treatment
  • 5-aza-CdR
  • AzaC
  • heating
  • KNK437
  • LPS
  • mutation
  • siRNA
  • TNF
  • trichostatin_A
  • vemurafenib
H3 (human) rtkQtArkstGGkAP K9-me
H3 (mouse) RtkQTARkstGGkAP K9-me
H3 iso2 (mouse) RTkQTARKsTGGkAP K9
H3 iso3 (mouse) RtKQTARKsTGGkAP K9
H3 (rat) RtkQTARKstGGkAP K9
H3 iso3 (rat) RTkQTARKsTGGkAP K9
H3 (pig) RTkQTARKSTGGkAP K9
H3 (chicken) RTkQTARKsTGGkAP K9
H3 (cow) RTkQTARKSTGGKAP K9
K9-m1
rtkQtArkstGGkAP
Upstream
Downstream
34 33
H3 (human)
K9-m1
H3 (mouse)
K9-m1
H3 iso2 (mouse)
K9-m1
H3 iso3 (mouse)
K9-m1
H3 (rat)
K9-m1
H3 iso3 (rat)
K9-m1
H3 (pig)
K9-m1
H3 (chicken)
K9-m1
H3 (cow)
K9-m1
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • cell cycle regulation
  • cell differentiation, induced
  • chromatin organization, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • HBB (human)
  • JMJD2C (human)
  • Myc (human)
  • PHF8 (human)
  • PKN1 (human)
  • PPP1CA (human)
Treatment
  • adriamycin
  • androstanolone
  • cell cycle regulated
  • colforsin
  • LLY-507
  • metribolone
  • pargyline
  • Ro31-8220
  • siRNA
  • ZM447439
H3 (human) rtkQtArkstGGkAP K9-m1
H3 (mouse) RtkQTARkstGGkAP K9-m1
H3 iso2 (mouse) RTkQTARKsTGGkAP K9
H3 iso3 (mouse) RtKQTARKsTGGkAP K9
H3 (rat) RtkQTARkstGGkAP K9-m1
H3 iso3 (rat) RTkQTARksTGGkAP K9-m1
H3 (pig) RTkQTARKSTGGkAP K9
H3 (chicken) RTkQTARKsTGGkAP K9
H3 (cow) RTkQTARKSTGGKAP K9
K9-m2
rtkQtArkstGGkAP
Upstream
Downstream
116 21
H3 (human)
K9-m2
H3 (mouse)
K9-m2
H3 iso2 (mouse)
K9-m2
H3 iso3 (mouse)
K9-m2
H3 (rat)
K9-m2
H3 iso3 (rat)
K9-m2
H3 (pig)
K9-m2
H3 (chicken)
K9-m2
H3 (cow)
K9-m2
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • methylation
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell cycle regulation
  • cell differentiation, induced
  • cell differentiation, inhibited
  • cell growth, induced
  • cell growth, inhibited
  • cell motility, induced
  • cell motility, inhibited
  • chromatin organization, altered
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • AurB (human)
  • CDK2 (human)
  • CUL4B (human)
  • CYLD (human)
  • CYLD (mouse)
  • EHMT1 (human)
  • EHMT2 (human)
  • HDAC1 (human)
  • HDAC2 (human)
  • HDAC3 (human)
  • HDAC6 (human)
  • HDAC8 (human)
  • HIF1A (human)
  • JAK2 (human)
  • JMJD1A (human)
  • JMJD1B (human)
  • MSK1 (human)
  • MTA1 (human)
  • Myb (human)
  • Myc (human)
  • MYST1 (human)
  • PC4 (human)
  • PHF8 (human)
  • PKN1 (human)
  • PPP1CA (human)
  • SETD8 (human)
  • UHRF1 (human)
  • WIZ (human)
  • ZNF644 (human)
Treatment
  • 17-beta-estradiol
  • 5-aza-CdR
  • A23187
  • adriamycin
  • AEBSF
  • amanitin
  • amphidicolin
  • androstanolone
  • AR42
  • AzaC
  • BIX01294
  • cell cycle regulated
  • chaetocin
  • CM272
  • CoCl2
  • colforsin
  • cycloheximide
  • deferoxamine
  • DMOG
  • doxycycline
  • ferric ammonium citrate
  • genistein
  • H-Leu-Leu-OMe
  • heat_shock
  • hypoxia
  • IL-11
  • IL-6
  • JIB04
  • LLY-507
  • LPS
  • metformin
  • methionine-deficient medium
  • metribolone
  • MS275
  • nafamostat
  • oncostatin_M
  • pargyline
  • phorbol_ester
  • Ro31-8220
  • short methylated oligonucleotide
  • siRNA
  • staurosporine
  • TNF
  • trichostatin_A
  • UNC0638
  • UNC1999
  • vorinostat
H3 (human) rtkQtArkstGGkAP K9-m2
H3 (mouse) RtkQTARkstGGkAP K9-m2
H3 iso2 (mouse) RTkQTARKsTGGkAP K9
H3 iso3 (mouse) RtKQTARKsTGGkAP K9
H3 (rat) RtkQTARkstGGkAP K9-m2
H3 iso3 (rat) RTkQTARKsTGGkAP K9
H3 (pig) RTkQTARkSTGGkAP K9-m2
H3 (chicken) RTkQTARksTGGkAP K9-m2
H3 (cow) RTkQTARkSTGGKAP K9-m2
K9-m3
rtkQtArkstGGkAP
Upstream
Downstream
131 25
H3 (human)
K9-m3
H3 (mouse)
K9-m3
H3 iso2 (mouse)
K9-m3
H3 iso3 (mouse)
K9-m3
H3 (rat)
K9-m3
H3 iso3 (rat)
K9-m3
H3 (pig)
K9-m3
H3 (chicken)
K9-m3
H3 (cow)
K9-m3
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • sumoylation
Effects on Biological Processes:
  • DNA repair, induced
  • apoptosis, induced
  • cell adhesion, induced
  • cell cycle regulation
  • cell differentiation, altered
  • cell differentiation, induced
  • cell differentiation, inhibited
  • cell growth, induced
  • cell motility, induced
  • chromatin organization, altered
  • cytoskeletal reorganization
  • transcription, altered
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • CUL4B (human)
  • EZH2 (human)
  • GLDC (human)
  • HBB (human)
  • HDAC1 (human)
  • HDAC2 (human)
  • HDAC3 (human)
  • HDAC6 (human)
  • HDAC8 (human)
  • JMJD2A (human)
  • KRBA1 (human)
  • LSD1 (human)
  • MTHFR (human)
  • Myc (human)
  • PHB (human)
  • PHF8 (human)
  • PKN1 (human)
  • PPME1 (human)
  • SIRT1 (human)
  • SUV39H1 (human)
  • SUV39H2 (human)
  • TIF1B (human)
  • ZNF263 (human)
Treatment
  • 5-aza-CdR
  • adriamycin
  • amino_acid_starvation
  • AR42
  • AzaC
  • cell cycle regulated
  • CEP-33779
  • CoCl2
  • colforsin
  • D9
  • dabrafenib
  • depsipeptide
  • docetaxel
  • DZNep
  • fedratinib
  • FIDAS-5
  • formate
  • geldanamycin
  • genistein
  • glucose_starvation
  • GSK126
  • hesperadin
  • homocysteine
  • ionizing_radiation
  • KU-55933
  • LLY-507
  • LPS
  • methionine-deficient medium
  • metribolone
  • miRNA
  • MS275
  • pargyline
  • PD0332991
  • rapamycin
  • retinoic_acid
  • Ro31-8220
  • SAM
  • siRNA
  • TG101209
  • thrombin
  • Trametinib
  • trichostatin_A
  • vorinostat
H3 (human) rtkQtArkstGGkAP K9-m3
H3 (mouse) RtkQTARkstGGkAP K9-m3
H3 iso2 (mouse) RTkQTARKsTGGkAP K9
H3 iso3 (mouse) RtKQTARKsTGGkAP K9
H3 (rat) RtkQTARkstGGkAP K9-m3
H3 iso3 (rat) RTkQTARksTGGkAP K9-m3
H3 (pig) RTkQTARkSTGGkAP K9-m3
H3 (chicken) RTkQTARKsTGGkAP K9
H3 (cow) RTkQTARkSTGGKAP K9-m3
S10-p
tkQtArkstGGkAPr
Upstream
Downstream
237 16
H3 (human)
S10-p
H3 (mouse)
S10-p
H3 iso2 (mouse)
S10-p
H3 iso3 (mouse)
S10-p
H3 (rat)
S10-p
H3 iso3 (rat)
S10-p
H3 (chicken)
S10-p
H3 (cow)
S10-p
Effects on Modified Protein
  • acetylation
  • activity, induced
  • intracellular localization
  • methylation
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, induced
  • cell cycle regulation
  • cell growth, altered
  • cell growth, induced
  • chromatin organization, altered
  • cytoskeletal reorganization
  • transcription, altered
  • transcription, induced
Kinase, in vitro:
  • Akt2 (human)
  • AurA (human)
  • AurB (human)
  • AurC (human)
  • CDK8 (human)
  • MSK1 (human)
  • PAK1 (human)
  • PBK (human)
  • Pim1 (human)
  • PKACA (pig)
  • PKCT (human)
  • ROCK1 (human)
  • TGM2 (human)
  • TLK1 (human)
  • VRK1 (human)
Phosphatases, in vitro:
  • PPP2CA (human)
  • PPP2CA (mouse)
Putative in vivo kinases:
  • AurA (human)
  • AurB (human)
  • AurB (pig)
  • CDK8 (human)
  • IKKA (human)
  • MSK1 (human)
  • PAK1 (human)
  • PBK (human)
  • Pim1 (human)
  • ROCK1 (human)
  • RSK2 (human)
  • RSK2 (mouse)
  • TLK1 (human)
  • VRK1 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
Regulatory protein:
  • Abl (human)
  • ARPC1B (human)
  • ARPP-19 (human)
  • ATM (human)
  • AurA (human)
  • AurB (human)
  • CCNB1 (human)
  • CCNF (human)
  • CDC25A (human)
  • CDCA2 (human)
  • CDK1 (human)
  • ChaK2 (human)
  • Chk1 (human)
  • CYLD (human)
  • DAP3 (human)
  • Geminin (human)
  • HSF1 (human)
  • IKKA (human)
  • INCENP (human)
  • MAD2L1BP (human)
  • MSK1 (human)
  • MST1 (human)
  • NIPP-1 (human)
  • Oct4 (human)
  • p21Cip1 (human)
  • p53 (human)
  • PKM (human)
  • PLK1 (human)
  • PPP1R14A (human)
  • PPP2CA (human)
  • PPP4C (human)
  • RKIP (human)
  • SIRT5 (human)
  • SMEK2 (human)
  • Survivin (human)
  • TAO1 (human)
  • TAO3 (human)
  • TRF2 (human)
  • TRIP13 (human)
  • TTK (human)
  • USP16 (human)
Treatment
  • A23187
  • adriamycin
  • AEBSF
  • alpha2-macroglobulin
  • alvocidib
  • anisomycin
  • APIO-EE-9
  • arsenite
  • As2O3
  • ATP
  • AZD1152
  • AZD1775
  • AZD7762
  • bacterial infection
  • BAPTA-AM
  • Bergamottin
  • BI2536
  • BL-I
  • blebbistatin
  • butyrate
  • BX795
  • C5M
  • caffeine
  • calphostin_C
  • camptothecin
  • CD532
  • cell cycle regulated
  • CFI-402257
  • CHR-6494
  • ciclosporin
  • cisplatin
  • cocaine
  • colcemid
  • ConA
  • CPT
  • cycloheximide
  • depsipeptide
  • dexamethasone
  • DTBR
  • EGF
  • EGTA
  • estradiol
  • etoposide
  • gemcitabine
  • genistein
  • gold nanoparticles
  • H-89
  • H-Leu-Leu-OMe
  • heat_shock
  • hesperadin
  • HXDV
  • hydroxyurea
  • IL-1b
  • ionizing_radiation
  • JNK_inhibitor_I
  • KN-62
  • LPS
  • MG132
  • mimosine
  • MK1775
  • MK5108
  • MLN8054
  • MLN8237
  • MNLN8237
  • monastrol
  • nafamostat
  • nocodazole
  • okadaic_acid
  • olaparib
  • onvansertib
  • palbociclib
  • PD98059
  • peptide inhibitor
  • PHA-680632
  • phleomycin
  • phorbol_ester
  • Poloxin
  • rigosertib
  • RO-3306
  • rottlerin
  • SB202190
  • SB203580
  • serum
  • Sinomenine
  • siRNA
  • SKF81297
  • SKF86002
  • sorbitol
  • SP600125
  • taxol
  • thapsigargin
  • thymidine
  • TNF
  • trichostatin_A
  • troglitazone
  • UV
  • vanadate
  • VE-821
  • virus infection
  • vorinostat
  • VX-680
  • Z-VAD-FMK
  • ZM447439
H3 (human) tkQtArkstGGkAPr S10-p
H3 (mouse) tkQTARkstGGkAPr S10-p
H3 iso2 (mouse) TkQTARksTGGkAPR S10-p
H3 iso3 (mouse) tKQTARksTGGkAPR S10-p
H3 (rat) tkQTARkstGGkAPR S10-p
H3 iso3 (rat)