Other Species / Isoforms
  AMPKA1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S6-p
__MRRLSsWRKMATA
0 1
AMPKA1 (human) __MRRLSsWRKMATA S6-p
AMPKA1 iso2 (human) __MRRLSSWRKMATA S6
AMPKA1 (mouse) __MRRLSSWRKMATA S6
AMPKA1 (rat) __MRRLSSWRKMATA S6
AMPKA1 (fruit fly) __MPQMRAAAAEAVA A6
T32-p
GHYILGDtLGVGTFG
0 3
AMPKA1 (human) GHYILGDtLGVGTFG T32-p
AMPKA1 iso2 (human) GHYILGDTLGVGTFG T32
AMPKA1 (mouse) GHYILGDtLGVGTFG T32-p
AMPKA1 (rat) GHYILGDTLGVGTFG T32
AMPKA1 (fruit fly) GHYLLGATLGTGTFG T33
K40-ub
LGVGTFGkVKVGkHE
0 1
AMPKA1 (human) LGVGTFGkVKVGkHE K40-ub
AMPKA1 iso2 (human) LGVGTFGKVKVGKHE K40
AMPKA1 (mouse) LGVGTFGKVKVGKHE K40
AMPKA1 (rat) LGVGTFGKVKVGKHE K40
AMPKA1 (fruit fly) LGTGTFGKVKIGEHQ K41
K45-ub
FGkVKVGkHELTGHk
0 1
AMPKA1 (human) FGkVKVGkHELTGHk K45-ub
AMPKA1 iso2 (human) FGKVKVGKHELTGHK K45
AMPKA1 (mouse) FGKVKVGKHELTGHK K45
AMPKA1 (rat) FGKVKVGKHELTGHK K45
AMPKA1 (fruit fly) FGKVKIGEHQITRVK E46
K52-ub
kHELTGHkVAVKILN
0 1
AMPKA1 (human) kHELTGHkVAVKILN K52-ub
AMPKA1 iso2 (human) KHELTGHKVAVKILN K52
AMPKA1 (mouse) KHELTGHKVAVKILN K52
AMPKA1 (rat) KHELTGHKVAVKILN K52
AMPKA1 (fruit fly) EHQITRVKVAVKILN K53
K71-ub
RSLDVVGkIRREIQN
Downstream
1 1
Effects on Modified Protein
  • enzymatic activity, inhibited
AMPKA1 (human) RSLDVVGkIRREIQN K71-ub
AMPKA1 iso2 (human) RSLDVVGKIRREIQN K71
AMPKA1 (mouse) RSLDVVGKIRREIQN K71
AMPKA1 (rat) RSLDVVGKIRREIQN K71
AMPKA1 (fruit fly) KSLDVVGKIRREIQN K72
K80-ac
RREIQNLkLFRHPHI
0 4
AMPKA1 (human) RREIQNLkLFRHPHI K80-ac
AMPKA1 iso2 (human) RREIQNLKLFRHPHI K80
AMPKA1 (mouse) RREIQNLkLFRHPHI K80-ac
AMPKA1 (rat) RREIQNLkLFRHPHI K80-ac
AMPKA1 (fruit fly) RREIQNLKLFRHPHI K81
K118-sm
ELFDYICkNGRLDEK
Downstream
1 0
Effects on Modified Protein
  • protein stabilization
AMPKA1 (human) ELFDYICkNGRLDEK K118-sm
AMPKA1 iso2 (human) ELFDYICKNGRKSDV K118
AMPKA1 (mouse) ELFDYICKNGRLDEK K118
AMPKA1 (rat) ELFDYICKNGRLDEK K118
AMPKA1 (fruit fly) ELFDYIVKHGKLQEH K119
-
gap
0 1
AMPKA1 (human) gap -
AMPKA1 iso2 (human) SDVPGVVkTGSTKEL K130-ub
AMPKA1 (mouse) gap -
AMPKA1 (rat) gap -
AMPKA1 (fruit fly) gap -
S172-p
KIADFGLsNMMsDGE
Upstream
Downstream
9 5
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • carcinogenesis, inhibited
  • signaling pathway regulation
Regulatory protein:
  • DNAPK (human)
  • SLC1A5 (human)
  • SLC6A14 (human)
  • SLC7A5 (human)
view more >
Treatment
  • 4-hydroperoxycyclophosphamide
  • A-769662
  • amino_acid_starvation
  • amino_acids
  • busulfan
  • cisplatin
  • compound_C
  • Cucurbitacin-E
  • fludarabine
  • glucose_starvation
  • hypoxia
  • metformin
  • methionine-deficient medium
  • NU7026
  • NU7441
  • venetoclax
view more >
AMPKA1 (human) KIADFGLsNMMsDGE S172-p
AMPKA1 iso2 (human) KIADFGLSNMMSDGE S187
AMPKA1 (mouse) KIADFGLsNMMsDGE S172-p
AMPKA1 (rat) KIADFGLSNMMSDGE S172
AMPKA1 (fruit fly) KIADFGLSNMMLDGE S173
S176-p
FGLsNMMsDGEFLRt
0 5
AMPKA1 (human) FGLsNMMsDGEFLRt S176-p
AMPKA1 iso2 (human) FGLSNMMSDGEFLRT S191
AMPKA1 (mouse) FGLsNMMsDGEFLRt S176-p
AMPKA1 (rat) FGLSNMMSDGEFLRt S176
AMPKA1 (fruit fly) FGLSNMMLDGEFLRT L177
T183-p
sDGEFLRtsCGsPNY
Upstream
Downstream
238 48
AMPKA1 (human)
T183-p
AMPKA1 (mouse)
T183-p
AMPKA1 (rat)
T183-p
AMPKA1 (fruit fly)
T184-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
  • autophagy, induced
  • carcinogenesis, induced
  • cell cycle regulation
  • cell differentiation, inhibited
  • cell growth, induced
  • cell growth, inhibited
  • signaling pathway regulation
  • transcription, induced
Kinase, in vitro:
  • AMPKA1 (human)
  • BRSK1 iso2 (human)
  • BRSK2 (human)
  • CAMK2B (human)
  • CAMKK2 (human)
  • LKB1 (human)
  • MLK3 (human)
  • MST1 (human)
  • MST2 (human)
  • MST3 (human)
  • MST4 (human)
view more >
Phosphatases, in vitro:
  • PPP2CA (human)
Putative in vivo kinases:
  • AMPKA1 (human)
  • CAMKK1 (human)
  • CAMKK2 (human)
  • LKB1 (human)
  • LKB1 (mouse)
  • MLK3 (human)
view more >
Putative upstream phosphatases:
  • PPM1E (human)
Regulatory protein:
  • ALDOA (human)
  • AMPKA1 (human)
  • ATM (human)
  • CAB39 (human)
  • CAMKK1 (human)
  • CBLL1 (human)
  • CLPX (human)
  • EEF2K (human)
  • EGFR (human)
  • EGLN1 (human)
  • eNOS (human)
  • GRK2 (human)
  • HK1 (human)
  • HRas (human)
  • JAK2 (human)
  • KLK1 (human)
  • LEPR (human)
  • LKB1 (human)
  • LKB1 (mouse)
  • MAGE-A6 (human)
  • MAGEA3 (human)
  • p27Kip1 (human)
  • PKCZ (human)
  • PKM (human)
  • PKM iso2 (human)
  • PPM1F (human)
  • PPP2CA (human)
  • PPP2CA (mouse)
  • PPPM1A (human)
  • SESN2 (mouse)
  • SIRT1 (human)
  • SIRT2 (human)
  • SKP2 (human)
  • SOCS3 (human)
  • STAT3 (human)
  • TET2 (human)
  • TIF1B (human)
  • ULK1 (human)
  • VHL (human)
view more >
Treatment
  • 2-deoxyglucose
  • 4-AN
  • 4-HT
  • 5-ammoniolevulinate
  • 991
  • 9cRA
  • A-769662
  • A23187
  • A79662
  • acadesine
  • ADI-PEG20
  • adiponectin
  • AdipoRon
  • AG1478
  • apelin
  • apoA-I
  • apocynin
  • arcyriarubin_A
  • aspirin
  • atorvastatin
  • ATP
  • bafilomycin_A
  • BAPTA-AM
  • berberine
  • bradykinin
  • C2-ceramide
  • C5M
  • cAMP_analog
  • CCCP
  • cGMP_analog
  • cigarette_smoke
  • CITCO
  • CL316,243
  • colforsin
  • compound_C
  • DEA-NONOate
  • DETA-NONOate
  • dexamethasone
  • DMOG
  • EDTA
  • EGF
  • emodin
  • etoposide
  • exercise
  • exercise training
  • FGF21
  • fibronectin
  • fluid_shear_stress
  • fumonisin_B1
  • glucose
  • glucose_starvation
  • glutamine
  • Go_6983
  • GSK621
  • GW_9662
  • H-89
  • H-CHO
  • H2O2
  • HH-F3
  • high_glucose
  • histamine
  • hypoxia
  • IGF-1
  • imatinib
  • indirubin
  • insulin
  • ionomycin
  • itraconazol
  • JQ1
  • KT5823
  • L-CHO
  • L-NAME
  • laminar flow
  • leptin
  • low_glucose
  • low_temperature
  • LPS
  • LY294002
  • mannitol
  • metformin
  • Mg(+2)
  • miR-451
  • miRNA
  • myocardial infarction
  • NAC
  • nicotinamide
  • nocodazole
  • ODQ
  • okadaic_acid
  • oleic_acid
  • oligomycin
  • ONOO(-)
  • oscillatory_flow
  • palmitate
  • palmitoleic_acid
  • PD153035
  • PD98059
  • PDTC
  • phenformin
  • phenobarbital
  • pioglitazone
  • PKC-zeta_inhibitor
  • PTIO
  • quercetin
  • racepinefrine
  • rapamycin
  • resveratrol
  • retinoic_acid
  • rosiglitazone
  • rotenone
  • S17834
  • salicylate
  • SB203580
  • seocalcitol
  • simvastatin
  • siRNA
  • SNAP
  • SNP
  • sorafenib
  • sorbitol
  • spermine
  • splitomicin
  • starvation_medium
  • statin
  • STO-609
  • SU6656
  • tamoxifen
  • thapsigargin
  • thrombin
  • TNF
  • triptolide
  • troglitazone
  • U73122
  • urofollitropin
  • UV
  • VEGF
  • wortmannin
view more >
AMPKA1 (human) sDGEFLRtsCGsPNY T183-p
AMPKA1 iso2 (human) SDGEFLRTSCGSPNY T198
AMPKA1 (mouse) sDGEFLRtsCGsPNY T183-p
AMPKA1 (rat) SDGEFLRtsCGSPNY T183-p
AMPKA1 (fruit fly) LDGEFLRTSCGSPNY T184
S184-p
DGEFLRtsCGsPNYA
2 20
AMPKA1 (human) DGEFLRtsCGsPNYA S184-p
AMPKA1 iso2 (human) DGEFLRTSCGSPNYA S199
AMPKA1 (mouse) DGEFLRtsCGsPNYA S184-p
AMPKA1 (rat) DGEFLRtsCGSPNYA S184-p
AMPKA1 (fruit fly) DGEFLRTSCGSPNYA S185
S187-p
FLRtsCGsPNYAAPE
0 18
AMPKA1 (human) FLRtsCGsPNYAAPE S187-p
AMPKA1 iso2 (human) FLRTSCGSPNYAAPE S202
AMPKA1 (mouse) FLRtsCGsPNYAAPE S187-p
AMPKA1 (rat) FLRtsCGSPNYAAPE S187
AMPKA1 (fruit fly) FLRTSCGSPNYAAPE S188
Y247-p
GIFYTPQyLNPSVIS
0 1
AMPKA1 (human) GIFYTPQyLNPSVIS Y247-p
AMPKA1 iso2 (human) GIFYTPQYLNPSVIS Y262
AMPKA1 (mouse) GIFYTPQYLNPSVIS Y247
AMPKA1 (rat) GIFYTPQYLNPSVIS Y247
AMPKA1 (fruit fly) GIFPIPEYLNKQVVN Y248
K266-ub
MLQVDPMkRATIKDI
0 2
AMPKA1 (human) MLQVDPMkRATIKDI K266-ub
AMPKA1 iso2 (human) MLQVDPMKRATIKDI K281
AMPKA1 (mouse) MLQVDPMKRAAIKDI K266
AMPKA1 (rat) MLQVDPMKRAtIKDI K266
AMPKA1 (fruit fly) MLQVDPLKRANIEEI K267
T269
VDPMkRATIKDIREH
2 1
AMPKA1 (human) VDPMkRATIKDIREH T269
AMPKA1 iso2 (human) VDPMKRATIKDIREH T284
AMPKA1 (mouse) VDPMKRAAIKDIREH A269
AMPKA1 (rat) VDPMKRAtIKDIREH T269-p
AMPKA1 (fruit fly) VDPLKRANIEEIKKH N270
K280-ub
IREHEWFkQDLPkYL
0 2
AMPKA1 (human) IREHEWFkQDLPkYL K280-ub
AMPKA1 iso2 (human) IREHEWFKQDLPKYL K295
AMPKA1 (mouse) IREHEWFKQDLPKYL K280
AMPKA1 (rat) IREHEWFKQDLPKYL K280
AMPKA1 (fruit fly) IKKHEWFQKDLPAYL Q281
K285-ub
WFkQDLPkYLFPEDP
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, inhibited
AMPKA1 (human) WFkQDLPkYLFPEDP K285-ub
AMPKA1 iso2 (human) WFKQDLPKYLFPEDP K300
AMPKA1 (mouse) WFKQDLPKYLFPEDP K285
AMPKA1 (rat) WFKQDLPKYLFPEDP K285
AMPKA1 (fruit fly) WFQKDLPAYLFPSSI A286
S293-p
YLFPEDPsySSTMID
0 2
AMPKA1 (human) YLFPEDPsySSTMID S293-p
AMPKA1 iso2 (human) YLFPEDPSYSSTMID S308
AMPKA1 (mouse) YLFPEDPSYSSTMID S293
AMPKA1 (rat) YLFPEDPSYSSTMID S293
AMPKA1 (fruit fly) YLFPSSIEQDSNVID E294
Y294-p
LFPEDPsySSTMIDD
0 10
AMPKA1 (human) LFPEDPsySSTMIDD Y294-p
AMPKA1 iso2 (human) LFPEDPSYSSTMIDD Y309
AMPKA1 (mouse) LFPEDPSYSSTMIDD Y294
AMPKA1 (rat) LFPEDPSYSSTMIDD Y294
AMPKA1 (fruit fly) LFPSSIEQDSNVIDT Q295
Y352-p
MNEAKDFyLAtsPPD
0 1
AMPKA1 (human) MNEAKDFyLAtsPPD Y352-p
AMPKA1 iso2 (human) MNEAKDFYLATSPPD Y367
AMPKA1 (mouse) MNEAKDFYLATsPPD Y352
AMPKA1 (rat) MNEAKDFYLATSPPD Y352
AMPKA1 (fruit fly) INEINNFFVAGSPPP F360
T355-p
AKDFyLAtsPPDsFL
0 2
AMPKA1 (human) AKDFyLAtsPPDsFL T355-p
AMPKA1 iso2 (human) AKDFYLATSPPDSFL T370
AMPKA1 (mouse) AKDFYLATsPPDsFL T355
AMPKA1 (rat) AKDFYLATSPPDsFL T355
AMPKA1 (fruit fly) INNFFVAGSPPPPPP G363
S356-p
KDFyLAtsPPDsFLD
0 8
AMPKA1 (human)
S356-p
AMPKA1 (mouse)
S356-p
AMPKA1 (rat)
S356-p
AMPKA1 (human) KDFyLAtsPPDsFLD S356-p
AMPKA1 iso2 (human) KDFYLATSPPDSFLD S371
AMPKA1 (mouse) KDFYLATsPPDsFLD S356-p
AMPKA1 (rat) KDFYLATSPPDsFLD S356
AMPKA1 (fruit fly) NNFFVAGSPPPPPPP S364
S360-p
LAtsPPDsFLDDHHL
Upstream
1 8
Kinase, in vitro:
  • AMPKA1 (human)
Treatment
  • MG132_withdrawal
AMPKA1 (human) LAtsPPDsFLDDHHL S360-p
AMPKA1 iso2 (human) LATSPPDSFLDDHHL S375
AMPKA1 (mouse) LATsPPDsFLDDHHL S360-p
AMPKA1 (rat) LATSPPDsFLDDHHL S360-p
AMPKA1 (fruit fly) PPPPVPQSSMDHQAP S376
T368
FLDDHHLTRPHPERV
0 1
AMPKA1 (human) FLDDHHLTRPHPERV T368
AMPKA1 iso2 (human) FLDDHHLTRPHPERV T383
AMPKA1 (mouse) FLDDHHLTRPHPERV T368
AMPKA1 (rat) FLDDHHLtRPHPERV T368-p
AMPKA1 (fruit fly) SSMDHQAPLATVTVG P383
T382-p
VPFLVAEtPRARHtL
Upstream
0 30
Treatment
  • selumetinib
AMPKA1 (human) VPFLVAEtPRARHtL T382-p
AMPKA1 iso2 (human) VPFLVAETPRARHTL T397
AMPKA1 (mouse) VPFLVAEtPRARHtL T382-p
AMPKA1 (rat) VPFLVAETPRARHTL T382
AMPKA1 (fruit fly) APMRDRQLAMSVQTS L432
T388-p
EtPRARHtLDELNPQ
Upstream
2 6
Kinase, in vitro:
  • AMPKA1 (human)
AMPKA1 (human) EtPRARHtLDELNPQ T388-p
AMPKA1 iso2 (human) ETPRARHTLDELNPQ T403
AMPKA1 (mouse) EtPRARHtLDELNPQ T388-p
AMPKA1 (rat) ETPRARHTLDELNPQ T388
AMPKA1 (fruit fly) QLAMSVQTSGGGAFP T438
K396-ub
LDELNPQksKHQGVR
Downstream
1 4
Effects on Modified Protein
  • enzymatic activity, inhibited
AMPKA1 (human) LDELNPQksKHQGVR K396-ub
AMPKA1 iso2 (human) LDELNPQKSKHQGVR K411
AMPKA1 (mouse) LDELNPQkSKHQGVR K396-ub
AMPKA1 (rat) LDELNPQKsKHQGVR K396
AMPKA1 (fruit fly) GGGAFPEKTARGGTP K447
S397-p
DELNPQksKHQGVRK
0 3
AMPKA1 (human) DELNPQksKHQGVRK S397-p
AMPKA1 iso2 (human) DELNPQKSKHQGVRK S412
AMPKA1 (mouse) DELNPQkSKHQGVRK S397
AMPKA1 (rat) DELNPQKsKHQGVRK S397-p
AMPKA1 (fruit fly) GGAFPEKTARGGTPI T448
K429-ub
AEVCRAIkQLDYEWK
0 2
AMPKA1 (human) AEVCRAIkQLDYEWK K429-ub
AMPKA1 iso2 (human) AEVCRAIKQLDYEWK K444
AMPKA1 (mouse) AEVCRAIKQLDYEWK K429
AMPKA1 (rat) AEVCRAIKQLDYEWK K429
AMPKA1 (fruit fly) LEVYRAMKALSYEWK K482
Y441-p
EWKVVNPyyLRVRRk
1 2
AMPKA1 (human) EWKVVNPyyLRVRRk Y441-p
AMPKA1 iso2 (human) EWKVVNPYYLRVRRK Y456
AMPKA1 (mouse) EWKVVNPYyLRVRRK Y441
AMPKA1 (rat) EWKVVNPyYLRVRRK Y441-p
AMPKA1 (fruit fly) EWKIINPYHVRVRRQ Y494
Y442-p
WKVVNPyyLRVRRkN
0 10
AMPKA1 (human) WKVVNPyyLRVRRkN Y442-p
AMPKA1 iso2 (human) WKVVNPYYLRVRRKN Y457
AMPKA1 (mouse) WKVVNPYyLRVRRKN Y442-p
AMPKA1 (rat) WKVVNPyYLRVRRKN Y442
AMPKA1 (fruit fly) WKIINPYHVRVRRQN H495
K448-ub
yyLRVRRkNPVTSTY
0 1
AMPKA1 (human) yyLRVRRkNPVTSTY K448-ub
AMPKA1 iso2 (human) YYLRVRRKNPVTSTY K463
AMPKA1 (mouse) YyLRVRRKNPVTSTF K448
AMPKA1 (rat) yYLRVRRKNPVTSTF K448
AMPKA1 (fruit fly) YHVRVRRQNVKTGKF Q501
Y463-p
SKMSLQLyQVDsRTY
0 2
AMPKA1 (human) SKMSLQLyQVDsRTY Y463-p
AMPKA1 iso2 (human) SKMSLQLYQVDSRTY Y478
AMPKA1 (mouse) SKMSLQLYQVDSRTY Y463
AMPKA1 (rat) SKMSLQLYQVDSRTY Y463
AMPKA1 (fruit fly) SKMSLQLYQVDAKSY Y516
S467-p
LQLyQVDsRTYLLDF
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, inhibited
  • phosphorylation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, induced
  • cell motility, induced
Kinase, in vitro:
  • Pim2 (human)
Putative in vivo kinases:
  • Pim2 (human)
Treatment
  • glucose
  • siRNA
  • SMI-4a
view more >
AMPKA1 (human) LQLyQVDsRTYLLDF S467-p
AMPKA1 iso2 (human) LQLYQVDSRTYLLDF S482
AMPKA1 (mouse) LQLYQVDSRTYLLDF S467
AMPKA1 (rat) LQLYQVDSRTYLLDF S467
AMPKA1 (fruit fly) LQLYQVDAKSYLLDF A520
T482-p
RSIDDEItEAksGtA
Upstream
1 4
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
AMPKA1 (human) RSIDDEItEAksGtA T482-p
AMPKA1 iso2 (human) RSIDDEITEAKSGTA T497
AMPKA1 (mouse) RSIDDEItEAKsGtA T482-p
AMPKA1 (rat) RSIDDEITEAKsGtA T482
AMPKA1 (fruit fly) gap -
K485-ub
DDEItEAksGtAtPQ
Downstream
1 5
Effects on Modified Protein
  • enzymatic activity, inhibited
AMPKA1 (human) DDEItEAksGtAtPQ K485-ub
AMPKA1 iso2 (human) DDEITEAKSGTATPQ K500
AMPKA1 (mouse) DDEItEAKsGtAtPQ K485
AMPKA1 (rat) DDEITEAKsGtAtPQ K485
AMPKA1 (fruit fly) gap -
S486-p
DEItEAksGtAtPQR
Upstream
2 47
Kinase, in vitro:
  • AMPKA1 (human)
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • nocodazole
  • thymidine
AMPKA1 (human) DEItEAksGtAtPQR S486-p
AMPKA1 iso2 (human) DEITEAKSGTATPQR S501
AMPKA1 (mouse) DEItEAKsGtAtPQR S486-p
AMPKA1 (rat) DEITEAKsGtAtPQR S486-p
AMPKA1 (fruit fly) gap -
T488-p
ItEAksGtAtPQRsG
0 14
AMPKA1 (human) ItEAksGtAtPQRsG T488-p
AMPKA1 iso2 (human) ITEAKSGTATPQRSG T503
AMPKA1 (mouse) ItEAKsGtAtPQRsG T488-p
AMPKA1 (rat) ITEAKsGtAtPQRSG T488-p
AMPKA1 (fruit fly) gap -
T490-p
EAksGtAtPQRsGsV
Upstream
Downstream
1 86
Effects on Modified Protein
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • autophagy, inhibited
  • transcription, induced
  • translation, induced
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3A (human)
  • GSK3B (human)
Regulatory protein:
  • Akt1 (human)
  • TSC1 (human)
Treatment
  • BIO
  • CHIR99021
  • insulin
  • lithium
  • meal feeding
  • MG132_withdrawal
  • nocodazole
  • serum
  • siRNA
  • thymidine
view more >
AMPKA1 (human) EAksGtAtPQRsGsV T490-p
AMPKA1 iso2 (human) EAKSGTATPQRSGSV T505
AMPKA1 (mouse) EAKsGtAtPQRsGsI T490-p
AMPKA1 (rat) EAKsGtAtPQRSGsI T490-p
AMPKA1 (fruit fly) gap -
S494-p
GtAtPQRsGsVsNyR
Upstream
Downstream
4 16
Effects on Modified Protein
  • phosphorylation
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • IL-18
  • insulin
AMPKA1 (human) GtAtPQRsGsVsNyR S494-p
AMPKA1 iso2 (human) GTATPQRSGSVSNYR S509
AMPKA1 (mouse) GtAtPQRsGsIsNYR S494-p
AMPKA1 (rat) GtAtPQRSGsISNYR S494
AMPKA1 (fruit fly) gap -
S496-p
AtPQRsGsVsNyRSC
Upstream
Downstream
20 101
AMPKA1 (human)
S496-p
AMPKA1 (mouse)
S496-p
AMPKA1 (rat)
S496-p
Effects on Modified Protein
  • enzymatic activity, inhibited
Kinase, in vitro:
  • Akt1 (human)
  • AMPKA1 (human)
  • PKCA (human)
view more >
Putative in vivo kinases:
  • PKCA (cow)
  • PKCB (human)
Treatment
  • Akt_inhibitor_VIII
  • angiotensin_2
  • development
  • Diphereline
  • EGF
  • ischemia
  • LY333531
  • metformin
  • MG132
  • MG132_withdrawal
  • okadaic_acid
  • PD184352
  • phorbol_ester
  • U0126
  • VEGF
  • wortmannin
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AMPKA1 (human) AtPQRsGsVsNyRSC S496-p
AMPKA1 iso2 (human) ATPQRSGSVSNYRSC S511
AMPKA1 (mouse) AtPQRsGsIsNYRsC S496-p
AMPKA1 (rat) AtPQRSGsISNYRSC S496-p
AMPKA1 (fruit fly) gap -
S498-p
PQRsGsVsNyRSCQR
0 7
AMPKA1 (human) PQRsGsVsNyRSCQR S498-p
AMPKA1 iso2 (human) PQRSGSVSNYRSCQR S513
AMPKA1 (mouse) PQRsGsIsNYRsCQR S498-p
AMPKA1 (rat) PQRSGsISNYRSCQR S498
AMPKA1 (fruit fly) LLDFKSLTNDEVEQG T531
Y500-p
RsGsVsNyRSCQRsD
0 24
AMPKA1 (human) RsGsVsNyRSCQRsD Y500-p
AMPKA1 iso2 (human) RSGSVSNYRSCQRSD Y515
AMPKA1 (mouse) RsGsIsNYRsCQRSD Y500
AMPKA1 (rat) RSGsISNYRSCQRSD Y500
AMPKA1 (fruit fly) DFKSLTNDEVEQGDD D533
S502
GsVsNyRSCQRsDsD
1 0
AMPKA1 (human) GsVsNyRSCQRsDsD S502
AMPKA1 iso2 (human) GSVSNYRSCQRSDSD S517
AMPKA1 (mouse) GsIsNYRsCQRSDsD S502-p
AMPKA1 (rat) GsISNYRSCQRSDSD S502
AMPKA1 (fruit fly) KSLTNDEVEQGDDVI V535
S506-p
NyRSCQRsDsDAEAQ
0 1
AMPKA1 (human) NyRSCQRsDsDAEAQ S506-p
AMPKA1 iso2 (human) NYRSCQRSDSDAEAQ S521
AMPKA1 (mouse) NYRsCQRSDsDAEAQ S506
AMPKA1 (rat) NYRSCQRSDSDAEAQ S506
AMPKA1 (fruit fly) NDEVEQGDDVIMESL D539
S508-p
RSCQRsDsDAEAQGk
2 27
AMPKA1 (human) RSCQRsDsDAEAQGk S508-p
AMPKA1 iso2 (human) RSCQRSDSDAEAQGK S523
AMPKA1 (mouse) RsCQRSDsDAEAQGK S508-p
AMPKA1 (rat) RSCQRSDSDAEAQGK S508
AMPKA1 (fruit fly) EVEQGDDVIMESLTP V541
K515-ub
sDAEAQGkSSEVsLt
0 1
AMPKA1 (human) sDAEAQGkSSEVsLt K515-ub
AMPKA1 iso2 (human) SDAEAQGKSSEVSLT K530
AMPKA1 (mouse) sDAEAQGKPSDVSLT K515
AMPKA1 (rat) SDAEAQGKPSEVSLT K515
AMPKA1 (fruit fly) gap -
S520-p
QGkSSEVsLtssVts
0 1
AMPKA1 (human) QGkSSEVsLtssVts S520-p
AMPKA1 iso2 (human) QGKSSEVSLTSSVTS S535
AMPKA1 (mouse) QGKPSDVSLTSsVTs S520
AMPKA1 (rat) QGKPSEVSLTSSVTS S520
AMPKA1 (fruit fly) GDDVIMESLTPPPLS S545
T522-p
kSSEVsLtssVtsLD
0 1
AMPKA1 (human) kSSEVsLtssVtsLD T522-p
AMPKA1 iso2 (human) KSSEVSLTSSVTSLD T537
AMPKA1 (mouse) KPSDVSLTSsVTsLD T522
AMPKA1 (rat) KPSEVSLTSSVTSLD T522
AMPKA1 (fruit fly) DVIMESLTPPPLSVS T547
S523-p
SSEVsLtssVtsLDS
0 1
AMPKA1 (human) SSEVsLtssVtsLDS S523-p
AMPKA1 iso2 (human) SSEVSLTSSVTSLDS S538
AMPKA1 (mouse) PSDVSLTSsVTsLDS S523
AMPKA1 (rat) PSEVSLTSSVTSLDS S523
AMPKA1 (fruit fly) VIMESLTPPPLSVSG P548
S524-p
SEVsLtssVtsLDSs
0 4
AMPKA1 (human) SEVsLtssVtsLDSs S524-p
AMPKA1 iso2 (human) SEVSLTSSVTSLDSS S539
AMPKA1 (mouse) SDVSLTSsVTsLDSS S524-p
AMPKA1 (rat) SEVSLTSSVTSLDSS S524
AMPKA1 (fruit fly) IMESLTPPPLSVSGV P549
T526-p
VsLtssVtsLDSsPV
0 1
AMPKA1 (human) VsLtssVtsLDSsPV T526-p
AMPKA1 iso2 (human) VSLTSSVTSLDSSPV T541
AMPKA1 (mouse) VSLTSsVTsLDSSPV T526
AMPKA1 (rat) VSLTSSVTSLDSSPV T526
AMPKA1 (fruit fly) ESLTPPPLSVSGVMP L551
S527-p
sLtssVtsLDSsPVD
Upstream
0 7
Treatment
  • metformin
AMPKA1 (human) sLtssVtsLDSsPVD S527-p
AMPKA1 iso2 (human) SLTSSVTSLDSSPVD S542
AMPKA1 (mouse) SLTSsVTsLDSSPVD S527-p
AMPKA1 (rat) SLTSSVTSLDSSPVD S527
AMPKA1 (fruit fly) SLTPPPLSVSGVMPL S552
S531-p
sVtsLDSsPVDLTPR
0 2
AMPKA1 (human) sVtsLDSsPVDLTPR S531-p
AMPKA1 iso2 (human) SVTSLDSSPVDLTPR S546
AMPKA1 (mouse) sVTsLDSSPVDVAPR S531
AMPKA1 (rat) SVTSLDSSPVDVAPR S531
AMPKA1 (fruit fly) PPPLSVSGVMPLQPT G555