K63
|
RAKDVAIKQIESESE
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
RAKDVAIkQIESESE
|
K63-ub
|
TAK1 iso2 (human)
|
RAKDVAIKQIESESE
|
K63
|
TAK1 (mouse)
|
RAKDVAIKQIESESE
|
K63
|
TAK1 iso3 (mouse)
|
RAKDVAIKQIESESE
|
K63
|
TAK1 (rat)
|
RAKDVAIKQIESESE
|
K63
|
|
K72
|
IESESERKAFIVELR
|
|
|
1
|
1
|
|
|
TAK1 (human)
|
IESESERkAFIVELR
|
K72-ub
|
TAK1 iso2 (human)
|
IESESERKAFIVELR
|
K72
|
TAK1 (mouse)
|
IESESERKAFIVELR
|
K72
|
TAK1 iso3 (mouse)
|
IESESERKAFIVELR
|
K72
|
TAK1 (rat)
|
IESESERKAFIVELR
|
K72
|
|
K158
|
ALIHRDLKPPNLLLV
|
|
|
3
|
0
|
|
|
TAK1 (human)
|
ALIHRDLkPPNLLLV
|
K158-ub
|
TAK1 iso2 (human)
|
ALIHRDLKPPNLLLV
|
K158
|
TAK1 (mouse)
|
ALIHRDLkPPNLLLV
|
K158-ub
|
TAK1 iso3 (mouse)
|
ALIHRDLKPPNLLLV
|
K158
|
TAK1 (rat)
|
ALIHRDLKPPNLLLV
|
K158
|
|
T178
|
LKICDFGTACDIQtH
|
|
|
3
|
0
|
|
|
TAK1 (human)
|
LKICDFGtACDIQtH
|
T178-p
|
TAK1 iso2 (human)
|
LKICDFGTACDIQTH
|
T178
|
TAK1 (mouse)
|
LKICDFGTACDIQtH
|
T178
|
TAK1 iso3 (mouse)
|
LKICDFGTACDIQtH
|
T178
|
TAK1 (rat)
|
LKICDFGTACDIQtH
|
T178
|
|
T178
|
LKICDFGTACDIQtH
|
|
|
1
|
1
|
|
|
TAK1 (human)
|
LKICDFGtACDIQtH
|
T178-ac
|
TAK1 iso2 (human)
|
LKICDFGTACDIQTH
|
T178
|
TAK1 (mouse)
|
LKICDFGTACDIQtH
|
T178
|
TAK1 iso3 (mouse)
|
LKICDFGTACDIQtH
|
T178
|
TAK1 (rat)
|
LKICDFGTACDIQtH
|
T178
|
|
T184-p
|
GTACDIQtHMtNNKG
|
Upstream
|
Downstream
|
20
|
0
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
Effects on Biological Processes:
- autophagy, induced
- cell cycle regulation
- cell growth, induced
- cell motility, induced
|
|
Treatment
- injury
- PDGF
- TAK1_inhibitor
|
|
TAK1 (human)
|
GtACDIQtHMtNNKG
|
T184-p
|
TAK1 iso2 (human)
|
GTACDIQTHMTNNKG
|
T184
|
TAK1 (mouse)
|
GTACDIQtHMtNNKG
|
T184-p
|
TAK1 iso3 (mouse)
|
GTACDIQtHMtNNKG
|
T184-p
|
TAK1 (rat)
|
GTACDIQtHMtNNKG
|
T184-p
|
|
T187-p
|
CDIQtHMtNNKGSAA
|
Upstream
|
Downstream
|
33
|
1
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
|
Effects on Biological Processes:
- autophagy, induced
- cell cycle regulation
- cell growth, induced
- cell motility, induced
|
|
Putative upstream phosphatases:
|
Treatment
- injury
- PDGF
- TAK1_inhibitor
|
|
TAK1 (human)
|
CDIQtHMtNNKGsAA
|
T187-p
|
TAK1 iso2 (human)
|
CDIQTHMTNNKGSAA
|
T187
|
TAK1 (mouse)
|
CDIQtHMtNNKGsAA
|
T187-p
|
TAK1 iso3 (mouse)
|
CDIQtHMtNNKGSAA
|
T187-p
|
TAK1 (rat)
|
CDIQtHMtNNKGSAA
|
T187-p
|
|
S192
|
HMtNNKGSAAWMAPE
|
|
|
5
|
1
|
|
|
TAK1 (human)
|
HMtNNKGsAAWMAPE
|
S192-p
|
TAK1 iso2 (human)
|
HMTNNKGSAAWMAPE
|
S192
|
TAK1 (mouse)
|
HMtNNKGsAAWMAPE
|
S192-p
|
TAK1 iso3 (mouse)
|
HMtNNKGSAAWMAPE
|
S192
|
TAK1 (rat)
|
HMtNNKGSAAWMAPE
|
S192
|
|
Y206
|
EVFEGSNYSEKCDVF
|
|
|
1
|
0
|
|
|
TAK1 (human)
|
EVFEGSNySEkCDVF
|
Y206-p
|
TAK1 iso2 (human)
|
EVFEGSNYSEKCDVF
|
Y206
|
TAK1 (mouse)
|
EVFEGSNYSEkCDVF
|
Y206
|
TAK1 iso3 (mouse)
|
EVFEGSNYSEKCDVF
|
Y206
|
TAK1 (rat)
|
EVFEGSNYSEKCDVF
|
Y206
|
|
K209
|
EGSNYSEKCDVFSWG
|
|
|
3
|
0
|
|
|
TAK1 (human)
|
EGSNySEkCDVFSWG
|
K209-ub
|
TAK1 iso2 (human)
|
EGSNYSEKCDVFSWG
|
K209
|
TAK1 (mouse)
|
EGSNYSEkCDVFSWG
|
K209-ub
|
TAK1 iso3 (mouse)
|
EGSNYSEKCDVFSWG
|
K209
|
TAK1 (rat)
|
EGSNYSEKCDVFSWG
|
K209
|
|
K269
|
LMTRCWSKDPSQRPS
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
LMTRCWSkDPSQRPS
|
K269-ub
|
TAK1 iso2 (human)
|
LMTRCWSKDPSQRPS
|
K269
|
TAK1 (mouse)
|
LMTRCWSKDPSQRPS
|
K269
|
TAK1 iso3 (mouse)
|
LMTRCWSKDPSQRPS
|
K269
|
TAK1 (rat)
|
LMTRCWSKDPSQRPS
|
K269
|
|
T333
|
NTSNKSDTNMEQVPA
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
NTSNKSDtNMEQVPA
|
T333-p
|
TAK1 iso2 (human)
|
NTSNKSDTNMEQVPA
|
T333
|
TAK1 (mouse)
|
NTSNKSDTNMEQVPA
|
T333
|
TAK1 iso3 (mouse)
|
NTSNKSDTNMEQVPA
|
T333
|
TAK1 (rat)
|
NTSNKSDTNMEQVPA
|
T333
|
|
T344
|
QVPATNDTIKRLESK
|
|
|
1
|
1
|
|
|
TAK1 (human)
|
QVPATNDtIkRLESk
|
T344-p
|
TAK1 iso2 (human)
|
QVPATNDTIKRLESK
|
T344
|
TAK1 (mouse)
|
QVPATNDTIKRLESK
|
T344
|
TAK1 iso3 (mouse)
|
QVPATNDTIKRLESK
|
T344
|
TAK1 (rat)
|
QVPATNDTIKRLESK
|
T344
|
|
K346
|
PATNDTIKRLESKLL
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
PATNDtIkRLESkLL
|
K346-ub
|
TAK1 iso2 (human)
|
PATNDTIKRLESKLL
|
K346
|
TAK1 (mouse)
|
PATNDTIKRLESKLL
|
K346
|
TAK1 iso3 (mouse)
|
PATNDTIKRLESKLL
|
K346
|
TAK1 (rat)
|
PATNDTIKRLESKLL
|
K346
|
|
K351
|
TIKRLESKLLKNQAK
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
tIkRLESkLLkNQAK
|
K351-ub
|
TAK1 iso2 (human)
|
TIKRLESKLLKNQAK
|
K351
|
TAK1 (mouse)
|
TIKRLESKLLKNQAK
|
K351
|
TAK1 iso3 (mouse)
|
TIKRLESKLLKNQAK
|
K351
|
TAK1 (rat)
|
TIKRLESKLLKNQAK
|
K351
|
|
K354
|
RLESKLLKNQAKQQS
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
RLESkLLkNQAKQQs
|
K354-ub
|
TAK1 iso2 (human)
|
RLESKLLKNQAKQQS
|
K354
|
TAK1 (mouse)
|
RLESKLLKNQAKQQs
|
K354
|
TAK1 iso3 (mouse)
|
RLESKLLKNQAKQQS
|
K354
|
TAK1 (rat)
|
RLESKLLKNQAKQQS
|
K354
|
|
S361
|
KNQAKQQSDSGRLSL
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
kNQAKQQsESGRLsL
|
S361-p
|
TAK1 iso2 (human)
|
KNQAKQQSESGRLSL
|
S361
|
TAK1 (mouse)
|
KNQAKQQsESGRLsL
|
S361-p
|
TAK1 iso3 (mouse)
|
KNQAKQQSESGRLSL
|
S361
|
TAK1 (rat)
|
KNQAKQQSDSGRLSL
|
S361
|
|
S367
|
QSDSGRLSLGASRGS
|
|
|
0
|
6
|
|
|
TAK1 (human)
|
QsESGRLsLGAsRGS
|
S367-p
|
TAK1 iso2 (human)
|
QSESGRLSLGASRGS
|
S367
|
TAK1 (mouse)
|
QsESGRLsLGAsRGS
|
S367-p
|
TAK1 iso3 (mouse)
|
QSESGRLSLGASRGS
|
S367
|
TAK1 (rat)
|
QSDSGRLSLGASRGS
|
S367
|
|
S371
|
GRLSLGASRGSSVES
|
|
|
0
|
6
|
|
|
TAK1 (human)
|
GRLsLGAsRGSsVES
|
S371-p
|
TAK1 iso2 (human)
|
GRLSLGASRGSSVES
|
S371
|
TAK1 (mouse)
|
GRLsLGAsRGSSVES
|
S371-p
|
TAK1 iso3 (mouse)
|
GRLSLGASRGSSVES
|
S371
|
TAK1 (rat)
|
GRLSLGASRGSSVES
|
S371
|
|
S375
|
LGASRGSSVESLPPT
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
LGAsRGSsVESLPPT
|
S375-p
|
TAK1 iso2 (human)
|
LGASRGSSVESLPPT
|
S375
|
TAK1 (mouse)
|
LGAsRGSSVESLPPT
|
S375
|
TAK1 iso3 (mouse)
|
LGASRGSSVESLPPT
|
S375
|
TAK1 (rat)
|
LGASRGSSVESLPPT
|
S375
|
|
K386
|
LPPTSEGKRMsADMS
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
LPPTSEGkRMsADMs
|
K386-ac
|
TAK1 iso2 (human)
|
LPPTSEGKRMSADMS
|
K386
|
TAK1 (mouse)
|
LPPTSEGKRMsADMs
|
K386
|
TAK1 iso3 (mouse)
|
LPPTSEGKRMSADMS
|
K386
|
TAK1 (rat)
|
LPPTSEGKRMsADMS
|
K386
|
|
S389-p
|
TSEGKRMsADMSEIE
|
Upstream
|
|
1
|
49
|
|
|
|
TAK1 (human)
|
TSEGkRMsADMsEIE
|
S389-p
|
TAK1 iso2 (human)
|
TSEGKRMSADMSEIE
|
S389
|
TAK1 (mouse)
|
TSEGKRMsADMsEIE
|
S389-p
|
TAK1 iso3 (mouse)
|
TSEGKRMSADMSEIE
|
S389
|
TAK1 (rat)
|
TSEGKRMsADMSEIE
|
S389-p
|
|
S393
|
KRMsADMSEIEARIV
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
kRMsADMsEIEARIA
|
S393-p
|
TAK1 iso2 (human)
|
KRMSADMSEIEARIA
|
S393
|
TAK1 (mouse)
|
KRMsADMsEIEARIV
|
S393-p
|
TAK1 iso3 (mouse)
|
KRMSADMSEIEARIV
|
S393
|
TAK1 (rat)
|
KRMsADMSEIEARIV
|
S393
|
|
Y405
|
RIVATTAYTKPKRGH
|
|
|
0
|
9
|
|
|
|
T406
|
IVATTAYTKPKRGHR
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
IAATTAysKPKRGHR
|
S406-p
|
TAK1 iso2 (human)
|
gap
|
-
|
TAK1 (mouse)
|
gap
|
-
|
TAK1 iso3 (mouse)
|
IVATAAySKPKRGHR
|
S406
|
TAK1 (rat)
|
IVATTAYTKPKRGHR
|
T406
|
|
T415
|
PKRGHRKTAsFGNIL
|
|
|
0
|
3
|
|
|
|
S417-p
|
RGHRKTAsFGNILDV
|
|
|
0
|
9
|
|
|
|
S439-p
|
NGQPRRRsIQDLTVT
|
|
|
9
|
146
|
|
|
|
TAK1 (human)
|
NGQPRRRsIQDLtVT
|
S439-p
|
TAK1 iso2 (human)
|
NGQPRRRSIQDLTVT
|
S412
|
TAK1 (mouse)
|
NGQPRRRsIQDLtVT
|
S412-p
|
TAK1 iso3 (mouse)
|
NGQPRRRsIQDLTVT
|
S439-p
|
TAK1 (rat)
|
NGQPRRRsIQDLTVT
|
S439-p
|
|
T444
|
RRsIQDLTVTGTEPG
|
|
|
1
|
5
|
|
|
TAK1 (human)
|
RRsIQDLtVTGtEPG
|
T444-p
|
TAK1 iso2 (human)
|
RRSIQDLTVTGTEPG
|
T417
|
TAK1 (mouse)
|
RRsIQDLtVTGTEPG
|
T417-p
|
TAK1 iso3 (mouse)
|
RRsIQDLTVTGTEPG
|
T444
|
TAK1 (rat)
|
RRsIQDLTVTGTEPG
|
T444
|
|
T448
|
QDLTVTGTEPGQVSS
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
QDLtVTGtEPGQVss
|
T448-p
|
TAK1 iso2 (human)
|
QDLTVTGTEPGQVSS
|
T421
|
TAK1 (mouse)
|
QDLtVTGTEPGQVss
|
T421
|
TAK1 iso3 (mouse)
|
QDLTVTGTEPGQVSS
|
T448
|
TAK1 (rat)
|
QDLTVTGTEPGQVSS
|
T448
|
|
S454
|
GTEPGQVSSRSSSPS
|
|
|
0
|
5
|
|
|
TAK1 (human)
|
GtEPGQVssRSssPS
|
S454-p
|
TAK1 iso2 (human)
|
GTEPGQVSSRSSSPS
|
S427
|
TAK1 (mouse)
|
GTEPGQVssRSssPS
|
S427-p
|
TAK1 iso3 (mouse)
|
GTEPGQVSSRSSSPS
|
S454
|
TAK1 (rat)
|
GTEPGQVSSRSSSPS
|
S454
|
|
S454
|
GTEPGQVSSRSSSPS
|
|
|
1
|
1
|
|
|
TAK1 (human)
|
GtEPGQVSsRSssPS
|
S454
|
TAK1 iso2 (human)
|
GTEPGQVSSRSSSPS
|
S427
|
TAK1 (mouse)
|
GTEPGQVssRSssPS
|
S427-gl
|
TAK1 iso3 (mouse)
|
GTEPGQVSSRSSSPS
|
S454
|
TAK1 (rat)
|
GTEPGQVSSRSSSPS
|
S454
|
|
S455
|
TEPGQVSSRSSSPSV
|
|
|
0
|
10
|
|
|
TAK1 (human)
|
tEPGQVssRSssPSV
|
S455-p
|
TAK1 iso2 (human)
|
TEPGQVSSRSSSPSV
|
S428
|
TAK1 (mouse)
|
TEPGQVssRSssPSV
|
S428-p
|
TAK1 iso3 (mouse)
|
TEPGQVSSRSSSPSV
|
S455
|
TAK1 (rat)
|
TEPGQVSSRSSSPSV
|
S455
|
|
S458
|
GQVSSRSSSPSVRMI
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
GQVssRSssPSVRMI
|
S458-p
|
TAK1 iso2 (human)
|
GQVSSRSSSPSVRMI
|
S431
|
TAK1 (mouse)
|
GQVssRSssPSVRMI
|
S431-p
|
TAK1 iso3 (mouse)
|
GQVSSRSSSPSVRMI
|
S458
|
TAK1 (rat)
|
GQVSSRSSSPSVRMI
|
S458
|
|
S459
|
QVSSRSSSPSVRMIT
|
|
|
0
|
3
|
|
|
TAK1 (human)
|
QVssRSssPSVRMIT
|
S459-p
|
TAK1 iso2 (human)
|
QVSSRSSSPSVRMIT
|
S432
|
TAK1 (mouse)
|
QVssRSssPSVRMIT
|
S432-p
|
TAK1 iso3 (mouse)
|
QVSSRSSSPSVRMIT
|
S459
|
TAK1 (rat)
|
QVSSRSSSPSVRMIT
|
S459
|
|
T471
|
MITTSGPTSEKPARS
|
|
|
1
|
1
|
|
|
TAK1 (human)
|
MITTSGPtsEkPTRS
|
T471-p
|
TAK1 iso2 (human)
|
MITTSGPTSEKPTRS
|
T444
|
TAK1 (mouse)
|
MITTSGPTSEKPARS
|
T444
|
TAK1 iso3 (mouse)
|
MITTSGPTSEKPARS
|
T471
|
TAK1 (rat)
|
MITTSGPTSEKPARS
|
T471
|
|
S472
|
ITTSGPTSEKPARSL
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
ITTSGPtsEkPTRSH
|
S472-p
|
TAK1 iso2 (human)
|
ITTSGPTSEKPTRSH
|
S445
|
TAK1 (mouse)
|
ITTSGPTSEKPARSH
|
S445
|
TAK1 iso3 (mouse)
|
ITTSGPTSEKPARSH
|
S472
|
TAK1 (rat)
|
ITTSGPTSEKPARSL
|
S472
|
|
K474
|
TSGPTSEKPARSLPW
|
|
|
0
|
3
|
|
|
TAK1 (human)
|
TSGPtsEkPTRSHPW
|
K474-ub
|
TAK1 iso2 (human)
|
TSGPTSEKPTRSHPW
|
K447
|
TAK1 (mouse)
|
TSGPTSEKPARSHPW
|
K447
|
TAK1 iso3 (mouse)
|
TSGPTSEKPARSHPW
|
K474
|
TAK1 (rat)
|
TSGPTSEKPARSLPW
|
K474
|
|
S492
|
DSTDTNGSDNSIPMA
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
DSTDTNGSDNSIPMA
|
S492
|
TAK1 iso2 (human)
|
DSTDTNGSDNSIPMA
|
S465
|
TAK1 (mouse)
|
DSTDTNGsDNSIPMA
|
S465-p
|
TAK1 iso3 (mouse)
|
DSTDTNGSDNSIPMA
|
S492
|
TAK1 (rat)
|
DSTDTNGSDNSIPMA
|
S492
|
|
T538
|
QEYMKVQTEIALLLQ
|
|
|
1
|
1
|
|
|
TAK1 (human)
|
QEYMKVQtEIALLLQ
|
T538-p
|
TAK1 iso2 (human)
|
QEYMKVQTEIALLLQ
|
T511
|
TAK1 (mouse)
|
QEYMKVQTEIALLLQ
|
T511
|
TAK1 iso3 (mouse)
|
QEYMKVQTEIALLLQ
|
T538
|
TAK1 (rat)
|
QEYMKVQTEIALLLQ
|
T538
|
|
K547
|
IALLLQRKQELVAEL
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
IALLLQRkQELVAEL
|
K547-ub
|
TAK1 iso2 (human)
|
IALLLQRKQELVAEL
|
K520
|
TAK1 (mouse)
|
IALLLQRKQELVAEL
|
K520
|
TAK1 iso3 (mouse)
|
IALLLQRKQELVAEL
|
K547
|
TAK1 (rat)
|
IALLLQRKQELVAEL
|
K547
|
|
K573
|
RLVQEHKKLLDENKS
|
|
|
0
|
1
|
|
|
TAK1 (human)
|
RLVQEHKkLLDENkS
|
K573-ac
|
TAK1 iso2 (human)
|
RLVQEHKKLLDENKS
|
K546
|
TAK1 (mouse)
|
RLVQEHKKLLDENKS
|
K546
|
TAK1 iso3 (mouse)
|
RLVQEHKKLLDENKS
|
K573
|
TAK1 (rat)
|
RLVQEHKKLLDENKS
|
K573
|
|
K579
|
KKLLDENKSLSTYYQ
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
KkLLDENkSLSTyyQ
|
K579-ub
|
TAK1 iso2 (human)
|
KKLLDENKSLSTYYQ
|
K552
|
TAK1 (mouse)
|
KKLLDENKSLSTYYQ
|
K552
|
TAK1 iso3 (mouse)
|
KKLLDENKSLSTYYQ
|
K579
|
TAK1 (rat)
|
KKLLDENKSLSTYYQ
|
K579
|
|
Y584
|
ENKSLSTYYQQCKKQ
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
ENkSLSTyyQQCKkQ
|
Y584-p
|
TAK1 iso2 (human)
|
ENKSLSTYYQQCKKQ
|
Y557
|
TAK1 (mouse)
|
ENKSLSTYYQQCKkQ
|
Y557
|
TAK1 iso3 (mouse)
|
ENKSLSTYYQQCKKQ
|
Y584
|
TAK1 (rat)
|
ENKSLSTYYQQCKKQ
|
Y584
|
|
Y585
|
NKSLSTYYQQCKKQL
|
|
|
0
|
2
|
|
|
TAK1 (human)
|
NkSLSTyyQQCKkQL
|
Y585-p
|
TAK1 iso2 (human)
|
NKSLSTYYQQCKKQL
|
Y558
|
TAK1 (mouse)
|
NKSLSTYYQQCKkQL
|
Y558
|
TAK1 iso3 (mouse)
|
NKSLSTYYQQCKKQL
|
Y585
|
TAK1 (rat)
|
NKSLSTYYQQCKKQL
|
Y585
|
|
K590
|
TYYQQCKKQLEVIRS
|
|
|
0
|
5
|
|
|
TAK1 (human)
|
TyyQQCKkQLEVIRS
|
K590-ub
|
TAK1 iso2 (human)
|
TYYQQCKKQLEVIRS
|
K563
|
TAK1 (mouse)
|
TYYQQCKkQLEVIRS
|
K563-ub
|
TAK1 iso3 (mouse)
|
TYYQQCKKQLEVIRS
|
K590
|
TAK1 (rat)
|
TYYQQCKKQLEVIRS
|
K590
|
|