Other Species / Isoforms
  MEK2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K6-ub
__MLARRkPVLPALt
0 2
MEK2 (human) __MLARRkPVLPALt K6-ub
MEK2 (mouse) __MLARRKPVLPALT K6
MEK2 (rat) __MLARRKPVLPALT K6
MEK2 (chicken) __MPAKRKPVLPALT K6
MEK2 (cow) __MLARRKPVLPALT K6
T13-ac
kPVLPALtINPTIAE
1 0
MEK2 (human) kPVLPALtINPTIAE T13-ac
MEK2 (mouse) KPVLPALTINPTIAE T13
MEK2 (rat) KPVLPALTINPTIAE T13
MEK2 (chicken) KPVLPALTITPSPAE T13
MEK2 (cow) KPVLPALTINPAIAE T13
S23-p
PTIAEGPsPTsEGAs
0 14
MEK2 (human) PTIAEGPsPTsEGAs S23-p
MEK2 (mouse) PTIAEGPsPtsEGAs S23-p
MEK2 (rat) PTIAEGPSPTSEGAS S23
MEK2 (chicken) PSPAEGPGPGGSAEA G23
MEK2 (cow) PAIAEGPSPTSEGAS S23
T25
IAEGPsPTsEGAsEA
0 1
MEK2 (human) IAEGPsPTsEGAsEA T25
MEK2 (mouse) IAEGPsPtsEGAsEA T25-p
MEK2 (rat) IAEGPSPTSEGASEA T25
MEK2 (chicken) PAEGPGPGGSAEANL G25
MEK2 (cow) IAEGPSPTSEGASEA T25
S26-p
AEGPsPTsEGAsEAN
0 3
MEK2 (human) AEGPsPTsEGAsEAN S26-p
MEK2 (mouse) AEGPsPtsEGAsEAN S26-p
MEK2 (rat) AEGPSPTSEGASEAH S26
MEK2 (chicken) gap -
MEK2 (cow) AEGPSPTSEGASEAH S26
S30-p
sPTsEGAsEANLVDL
0 3
MEK2 (human) sPTsEGAsEANLVDL S30-p
MEK2 (mouse) sPtsEGAsEANLVDL S30-p
MEK2 (rat) SPTSEGASEAHLVDL S30
MEK2 (chicken) GPGPGGSAEANLVDL A28
MEK2 (cow) SPTSEGASEAHLVDL S30
K40-ub
NLVDLQKkLEELELD
0 3
MEK2 (human) NLVDLQKkLEELELD K40-ub
MEK2 (mouse) NLVDLQKKLEELDLD K40
MEK2 (rat) HLVDLQKKLEELDLD K40
MEK2 (chicken) NLVDLQKKLEELELD K38
MEK2 (cow) HLVDLQKKLEELELD K40
K51-ub
LELDEQQkKRLEAFL
0 3
MEK2 (human) LELDEQQkKRLEAFL K51-ub
MEK2 (mouse) LDLDEQQRKRLEAFL R51
MEK2 (rat) LDLDEQQRKRLEAFL R51
MEK2 (chicken) LELDEQQKKRLEAFL K49
MEK2 (cow) LELDEQQKKRLEAFL K51
K61-ub
LEAFLTQkAkVGELk
0 2
MEK2 (human) LEAFLTQkAkVGELk K61-ub
MEK2 (mouse) LEAFLTQKAKVGELK K61
MEK2 (rat) LEAFLTQKAKVGELK K61
MEK2 (chicken) LEAFLTQKAKVGELK K59
MEK2 (cow) LEAFLTQKAKVGELK K61
K63-ub
AFLTQkAkVGELkDD
0 4
MEK2 (human) AFLTQkAkVGELkDD K63-ub
MEK2 (mouse) AFLTQKAKVGELKDD K63
MEK2 (rat) AFLTQKAKVGELKDD K63
MEK2 (chicken) AFLTQKAKVGELKDD K61
MEK2 (cow) AFLTQKAKVGELKDD K63
K68-ub
kAkVGELkDDDFERI
0 3
MEK2 (human) kAkVGELkDDDFERI K68-ub
MEK2 (mouse) KAKVGELKDDDFERI K68
MEK2 (rat) KAKVGELKDDDFERI K68
MEK2 (chicken) KAKVGELKDDDFERI K66
MEK2 (cow) KAKVGELKDDDFERI K68
S76
DDDFERISELGAGNG
0 1
MEK2 (human) DDDFERISELGAGNG S76
MEK2 (mouse) DDDFERIsELGAGNG S76-p
MEK2 (rat) DDDFERISELGAGNG S76
MEK2 (chicken) DDDFERISELGAGNG S74
MEK2 (cow) DDDFERISELGAGNG S76
K88-ub
GNGGVVTkVQHRPsG
0 4
MEK2 (human) GNGGVVTkVQHRPsG K88-ub
MEK2 (mouse) GNGGVVTkARHRPSG K88-ub
MEK2 (rat) GNGGVVTKARHRPSG K88
MEK2 (chicken) GNGGVVTKVQHKPSG K86
MEK2 (cow) GNGGVVTKVQHRPSG K88
S94-p
TkVQHRPsGLIMARk
0 1
MEK2 (human) TkVQHRPsGLIMARk S94-p
MEK2 (mouse) TkARHRPSGLIMARK S94
MEK2 (rat) TKARHRPSGLIMARK S94
MEK2 (chicken) TKVQHKPSGLIMARK S92
MEK2 (cow) TKVQHRPSGLIMARK S94
K101-ub
sGLIMARkLIHLEIk
0 11
MEK2 (human) sGLIMARkLIHLEIk K101-ub
MEK2 (mouse) SGLIMARKLIHLEIK K101
MEK2 (rat) SGLIMARKLIHLEIK K101
MEK2 (chicken) SGLIMARKLIHLEIK K99
MEK2 (cow) SGLIMARKLIHLEIK K101
K108-ub
kLIHLEIkPAIRNQI
0 15
MEK2 (human) kLIHLEIkPAIRNQI K108-ub
MEK2 (mouse) KLIHLEIKPAVRNQI K108
MEK2 (rat) KLIHLEIKPAVRNQI K108
MEK2 (chicken) KLIHLEIKPAIRNQI K106
MEK2 (cow) KLIHLEIKPAIRNQI K108
K108-sm
kLIHLEIkPAIRNQI
1 0
MEK2 (human) kLIHLEIkPAIRNQI K108-sm
MEK2 (mouse) KLIHLEIKPAVRNQI K108
MEK2 (rat) KLIHLEIKPAVRNQI K108
MEK2 (chicken) KLIHLEIKPAIRNQI K106
MEK2 (cow) KLIHLEIKPAIRNQI K108
K163-ub
DQVLKEAkRIPEEIL
0 1
MEK2 (human) DQVLKEAkRIPEEIL K163-ub
MEK2 (mouse) DQVLKEAKRIPEDIL K163
MEK2 (rat) DQVLKEAKRIPEDIL K163
MEK2 (chicken) DQVLKEAKRIPEEIL K161
MEK2 (cow) DQVLKEAKRIPEEIL K163
K196-ub
QIMHRDVkPSNILVN
0 30
MEK2 (human) QIMHRDVkPSNILVN K196-ub
MEK2 (mouse) QIMHRDVkPSNILVN K196-ub
MEK2 (rat) QIMHRDVkPSNILVN K196-ub
MEK2 (chicken) QIMHRDVKPSNILVN K194
MEK2 (cow) QIMHRDVKPSNILVN K196
K209-ub
VNSRGEIkLCDFGVs
0 11
MEK2 (human) VNSRGEIkLCDFGVs K209-ub
MEK2 (mouse) VNSRGEIKLCDFGVs K209
MEK2 (rat) VNSRGEIKLCDFGVS K209
MEK2 (chicken) VNSRGEIKLCDFGVS K207
MEK2 (cow) VNSRGEIKLCDFGVS K209
S216-p
kLCDFGVsGQLIDsM
Upstream
Downstream
3 5
Effects on Modified Protein
  • enzymatic activity, inhibited
Treatment
  • gefitinib
MEK2 (human) kLCDFGVsGQLIDsM S216-p
MEK2 (mouse) KLCDFGVsGQLIDsM S216-p
MEK2 (rat) KLCDFGVSGQLIDsM S216
MEK2 (chicken) KLCDFGVSGQLIDSM S214
MEK2 (cow) KLCDFGVSGQLIDSM S216
S222-p
VsGQLIDsMANsFVG
Upstream
Downstream
59 93
MEK2 (human)
S222-p
MEK2 (mouse)
S222-p
MEK2 (rat)
S222-p
MEK2 (chicken)
S220-p
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • BRAF (human)
  • Cot (human)
  • PLK1 (human)
Putative in vivo kinases:
  • Cot (human)
Regulatory protein:
  • CDK10 (human)
  • DUSP6 (human)
  • FMR1 (human)
  • GAB1 (human)
  • HePTP (human)
  • HRas (human)
  • HSP27 (human)
  • ILK (human)
  • KRas (human)
  • Lck (human)
  • MST2 (human)
  • PDGFRA (human)
  • PDGFRB (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PIN1 (human)
  • PKCE (human)
  • PLK1 (human)
  • PTPN2 (human)
  • PXN iso2 (human)
  • RAP1A (human)
  • Ret (human)
  • SHP-2 (human)
Treatment
  • adenosine
  • androstanolone
  • anti-CD3
  • anti-CD3/CD28
  • anti-IgM
  • cAMP_analog
  • colforsin
  • CTGF
  • diesel_exhaust
  • dronabinol
  • EGF
  • estrogen_deprivation
  • H-89
  • herbimycin_A
  • idelalisib
  • IGF-1
  • ischemia
  • isoproterenol
  • LPS
  • LY2090314
  • neuregulin
  • nocodazole
  • parbendazole
  • PDGF
  • phorbol_ester
  • pictilisib
  • PTX
  • racepinefrine
  • rapamycin
  • rigosertib
  • rimonabant
  • rosiglitazone
  • SB202190
  • SCH772984
  • sorafenib
  • SR_144528
  • staurosporine
  • Su11274
  • thymidine
  • TNF
  • U0126
  • wortmannin
  • Z-VAD-FMK
MEK2 (human) VsGQLIDsMANsFVG S222-p
MEK2 (mouse) VsGQLIDsMANsFVG S222-p
MEK2 (rat) VSGQLIDsMANsFVG S222-p
MEK2 (chicken) VSGQLIDSMANSFVG S220
MEK2 (cow) VSGQLIDSMANSFVG S222
S222-ac
VsGQLIDsMANsFVG
1 0
MEK2 (human) VsGQLIDsMANsFVG S222-ac
MEK2 (mouse) VsGQLIDSMANsFVG S222
MEK2 (rat) VSGQLIDSMANsFVG S222
MEK2 (chicken) VSGQLIDSMANSFVG S220
MEK2 (cow) VSGQLIDSMANSFVG S222
S226-p
LIDsMANsFVGTRSY
Upstream
Downstream
55 218
MEK2 (human)
S226-p
MEK2 (mouse)
S226-p
MEK2 (rat)
S226-p
MEK2 (chicken)
S224-p
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • BRAF (human)
  • Cot (human)
  • PDK1 (human)
  • PLK1 (human)
Putative in vivo kinases:
  • Cot (human)
  • PDK1 (human)
Regulatory protein:
  • CDK10 (human)
  • DUSP6 (human)
  • FMR1 (human)
  • GAB1 (human)
  • HePTP (human)
  • HRas (human)
  • HSP27 (human)
  • ILK (human)
  • KRas (human)
  • Lck (human)
  • MST2 (human)
  • PDGFRA (human)
  • PDGFRB (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PIN1 (human)
  • PKCE (human)
  • PLK1 (human)
  • PTPN2 (human)
  • PXN iso2 (human)
  • RAP1A (human)
  • Ret (human)
  • SHP-2 (human)
Treatment
  • adenosine
  • androstanolone
  • anti-CD3
  • anti-CD3/CD28
  • anti-IgM
  • cAMP_analog
  • colforsin
  • diesel_exhaust
  • dronabinol
  • EGF
  • estrogen_deprivation
  • gefitinib
  • H-89
  • herbimycin_A
  • idelalisib
  • IGF-1
  • isoproterenol
  • LPS
  • LY2090314
  • neuregulin
  • nocodazole
  • parbendazole
  • PDGF
  • phorbol_ester
  • PTX
  • racepinefrine
  • rapamycin
  • rigosertib
  • rimonabant
  • SB202190
  • sorafenib
  • SR_144528
  • staurosporine
  • Su11274
  • thymidine
  • TNF
  • U0126
  • vemurafenib
  • wortmannin
  • Z-VAD-FMK
MEK2 (human) LIDsMANsFVGTRSY S226-p
MEK2 (mouse) LIDsMANsFVGTRSY S226-p
MEK2 (rat) LIDsMANsFVGTRSY S226-p
MEK2 (chicken) LIDSMANSFVGTRSY S224
MEK2 (cow) LIDSMANSFVGTRSY S226
S226-ac
LIDsMANsFVGTRSY
1 0
MEK2 (human) LIDsMANsFVGTRSY S226-ac
MEK2 (mouse) LIDsMANSFVGTRSY S226
MEK2 (rat) LIDsMANSFVGTRSY S226
MEK2 (chicken) LIDSMANSFVGTRSY S224
MEK2 (cow) LIDSMANSFVGTRSY S226
D285-ca
IFGRPVVdGEEGEPH
0 1
MEK2 (human) IFGRPVVdGEEGEPH D285-ca
MEK2 (mouse) SFGRPVVDGADGEPH D285
MEK2 (rat) SFGRPVVDGADGEPH D285
MEK2 (chicken) IFGRPVVDGAEGESH D283
MEK2 (cow) IFGRPMVDGAEGEPP D285
S293-p
GEEGEPHsIsPRPRP
Upstream
0 19
Treatment
  • nocodazole
  • selumetinib
  • thymidine
  • vemurafenib
MEK2 (human) GEEGEPHsIsPRPRP S293-p
MEK2 (mouse) GADGEPHsVsPRPRP S293-p
MEK2 (rat) GADGEPHSVsPRPRP S293
MEK2 (chicken) GAEGESHSVSPWARP S291
MEK2 (cow) GAEGEPPSISPRPRP S293
S295-p
EGEPHsIsPRPRPPG
Upstream
1 28
Treatment
  • nocodazole
  • selumetinib
  • thymidine
  • vemurafenib
MEK2 (human) EGEPHsIsPRPRPPG S295-p
MEK2 (mouse) DGEPHsVsPRPRPPG S295-p
MEK2 (rat) DGEPHSVsPRPRPPG S295-p
MEK2 (chicken) EGESHSVSPWARPPG S293
MEK2 (cow) EGEPPSISPRPRPPG S295
S306-p
RPPGRPVsGHGMDsR
Upstream
Downstream
2 11
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell adhesion, induced
  • cell motility, induced
Regulatory protein:
  • EGF (human)
Treatment
  • wortmannin
MEK2 (human) RPPGRPVsGHGMDsR S306-p
MEK2 (mouse) RPPGRPIsVGHGMDS S306-p
MEK2 (rat) RPPGRPISGHGMDSR S306
MEK2 (chicken) RPPGRPISGHGMDSR S304
MEK2 (cow) RPPGRPISGHGMDSR S306
S312-p
VsGHGMDsRPAMAIF
0 2
MEK2 (human) VsGHGMDsRPAMAIF S312-p
MEK2 (mouse) sVGHGMDSRPAMAIF S313
MEK2 (rat) ISGHGMDSRPAMAIF S312
MEK2 (chicken) ISGHGMDSRPAMAIF S310
MEK2 (cow) ISGHGMDSRPAMAIF S312
K361-ub
PAERADLkMLTNHTF
0 3
MEK2 (human) PAERADLkMLTNHTF K361-ub
MEK2 (mouse) PAERADLkLLMNHAF K362-ub
MEK2 (rat) PAERADLKLLTNHAF K361
MEK2 (chicken) PAERADLKMLMNHTF K359
MEK2 (cow) PAERADLKMLMNHTF K361
K370-ub
LTNHTFIkRsEVEEV
0 2
MEK2 (human) LTNHTFIkRsEVEEV K370-ub
MEK2 (mouse) LMNHAFIKRSEGEEV K371
MEK2 (rat) LTNHAFIKRSEGEDV K370
MEK2 (chicken) LMNHTFIKRSEVEEV K368
MEK2 (cow) LMNHTFIKRSEVEEV K370
S372-p
NHTFIkRsEVEEVDF
0 1
MEK2 (human) NHTFIkRsEVEEVDF S372-p
MEK2 (mouse) NHAFIKRSEGEEVDF S373
MEK2 (rat) NHAFIKRSEGEDVDF S372
MEK2 (chicken) NHTFIKRSEVEEVDF S370
MEK2 (cow) NHTFIKRSEVEEVDF S372
K385-ub
DFAGWLCkTLRLNQP
0 1
MEK2 (human) DFAGWLCkTLRLNQP K385-ub
MEK2 (mouse) DFAGWLCRTLRLKQP R386
MEK2 (rat) DFAGWLCRTLRLKQP R385
MEK2 (chicken) DFAGWLCKTLRLNQP K383
MEK2 (cow) DFAGWLCKTLRLNQP K385
G393
TLRLNQPGtPtRtAV
0 8
MEK2 (human) TLRLNQPGtPtRtAV G393
MEK2 (mouse) TLRLKQPstPtRTAV S394-p
MEK2 (rat) TLRLKQPstPTRTAV S393-p
MEK2 (chicken) TLRLNQPSTPTRAAV S391
MEK2 (cow) TLRLNQPSTPTRTAV S393
T394-p
LRLNQPGtPtRtAV_
Upstream
2 113
Treatment
  • 2-deoxyglucose
  • angiotensin_2
  • ischemia
  • vemurafenib
MEK2 (human) LRLNQPGtPtRtAV_ T394-p
MEK2 (mouse) LRLKQPstPtRTAV_ T395-p
MEK2 (rat) LRLKQPstPTRTAV_ T394-p
MEK2 (chicken) LRLNQPSTPTRAAV_ T392
MEK2 (cow) LRLNQPSTPTRTAV_ T394
T396-p
LNQPGtPtRtAV___
Upstream
2 25
Treatment
  • angiotensin_2
MEK2 (human) LNQPGtPtRtAV___ T396-p
MEK2 (mouse) LKQPstPtRTAV___ T397-p
MEK2 (rat) LKQPstPTRTAV___ T396
MEK2 (chicken) LNQPSTPTRAAV___ T394
MEK2 (cow) LNQPSTPTRTAV___ T396
T398-p
QPGtPtRtAV_____
1 0
MEK2 (human) QPGtPtRtAV_____ T398-p
MEK2 (mouse) QPstPtRTAV_____ T399
MEK2 (rat) QPstPTRTAV_____ T398
MEK2 (chicken) QPSTPTRAAV_____ A396
MEK2 (cow) QPSTPTRTAV_____ T398