Other Species / Isoforms
  LRRK2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S3
_____MAsGsCQGCE
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) _____MAsGsCQGCE S3
LRRK2 (mouse) _____MASGACQGCE S3
LRRK2 (rat) _____MASGACQGCD S3
S5
___MAsGsCQGCEED
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) ___MAsGsCQGCEED S5
LRRK2 (mouse) ___MASGACQGCEEE A5
LRRK2 (rat) ___MASGACQGCDEE A5
T358
EACYKALtWHRKNKH
0 1
LRRK2 (human) EACYKALtWHRKNKH T358
LRRK2 (mouse) EPCYKALVRHRKDKH V360
LRRK2 (rat) EPCYKALMRHRKNKH M359
T424
ASANALStLLEQNVN
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) ASANALStLLEQNVN T424
LRRK2 (mouse) AAAHALSTLLEQNVN T426
LRRK2 (rat) AAAHALSTLLEQNVN T425
T489
AVVPKILtVMKRHEt
0 2
LRRK2 (human) AVVPKILtVMKRHEt T489
LRRK2 (mouse) AVVPKILTVMKAHGT T491
LRRK2 (rat) AVIPKILTVMRTHGT T490
T496
tVMKRHEtSLPVQLE
0 1
LRRK2 (human) tVMKRHEtSLPVQLE T496
LRRK2 (mouse) TVMKAHGTSLSVQLE T498
LRRK2 (rat) TVMRTHGTSLSVQLE T497
T524
PEESREDtEFHHKLN
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) PEESREDtEFHHKLN T524
LRRK2 (mouse) LEESREDSQCRPNVL S526
LRRK2 (rat) SEDSRDDSRCQPNVL S525
S633
LLAKILVssLyRFKD
0 1
LRRK2 (human) LLAKILVssLyRFKD S633
LRRK2 (mouse) LLAKILASTLQRFKD S633
LRRK2 (rat) LLAKILASTLQRFKD S632
S634
LAKILVssLyRFKDV
0 1
LRRK2 (human) LAKILVssLyRFKDV S634
LRRK2 (mouse) LAKILASTLQRFKDV T634
LRRK2 (rat) LAKILASTLQRFKDV T633
Y636
KILVssLyRFKDVAE
0 1
LRRK2 (human) KILVssLyRFKDVAE Y636
LRRK2 (mouse) KILASTLQRFKDVAE Q636
LRRK2 (rat) KILASTLQRFKDVAE Q635
Y707
AKVAMDDyLKNVMLE
0 1
LRRK2 (human) AKVAMDDyLKNVMLE Y707
LRRK2 (mouse) AKVAVDDELKNTMLE E707
LRRK2 (rat) AKVAVDDELKSKMLE E706
T776
QDVRKALtISIGKGD
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) QDVRKALtISIGKGD T776
LRRK2 (mouse) QDVRKALTVSIQKGD T776
LRRK2 (rat) QDVRKALTVSIQKGD T775
S784
ISIGKGDsQIIsLLL
0 1
LRRK2 (human) ISIGKGDsQIIsLLL S784
LRRK2 (mouse) VSIQKGDSQVISLLL S784
LRRK2 (rat) VSIQKGDNQVISLLL N783
S788
KGDsQIIsLLLRRLA
0 1
LRRK2 (human) KGDsQIIsLLLRRLA S788
LRRK2 (mouse) KGDSQVISLLLRKLA S788
LRRK2 (rat) KGDNQVISLLLRRLA S787
T826
GPLFPDKtSNLRKQt
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) GPLFPDKtSNLRKQt T826
LRRK2 (mouse) GPLFPDKSSNLRKQT S826
LRRK2 (rat) GPLFPDKSSNLRKQT S825
T833
tSNLRKQtNIAstLA
Upstream
0 2
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) tSNLRKQtNIAstLA T833
LRRK2 (mouse) SSNLRKQTNTGSVLA T833
LRRK2 (rat) SSNLRKQTNAGSVLA T832
S837
RKQtNIAstLARMVI
0 2
LRRK2 (human) RKQtNIAstLARMVI S837
LRRK2 (mouse) RKQTNTGSVLARKVL S837
LRRK2 (rat) RKQTNAGSVLARKVL S836
T838
KQtNIAstLARMVIR
Upstream
0 4
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KQtNIAstLARMVIR T838
LRRK2 (mouse) KQTNTGSVLARKVLR V838
LRRK2 (rat) KQTNAGSVLARKVLR V837
S850
VIRYQMKsAVEEGTA
0 3
LRRK2 (human) VIRYQMKsAVEEGTA S850
LRRK2 (mouse) VLRYQMRNTLQEGVA N850
LRRK2 (rat) VLRYQMRNTLQEGVA N849
S858
AVEEGTAsGsDGNFs
0 2
LRRK2 (human) AVEEGTAsGsDGNFs S858
LRRK2 (mouse) TLQEGVASGsDGKFS S858
LRRK2 (rat) TLQEGVASGSEGNFS S857
S860
EEGTAsGsDGNFsED
2 3
LRRK2 (human) EEGTAsGsDGNFsED S860
LRRK2 (mouse) QEGVASGsDGKFSED S860
LRRK2 (rat) QEGVASGSEGNFSED S859
S865
sGsDGNFsEDVLSKF
0 1
LRRK2 (human) sGsDGNFsEDVLSKF S865
LRRK2 (mouse) SGsDGKFSEDALAKF S865
LRRK2 (rat) SGSEGNFSEDALAKF S864
S895
AQSDDLDsEGsEGSF
0 1
LRRK2 (human) AQSDDLDsEGsEGSF S895
LRRK2 (mouse) GQSDDLDSEGSESSF S895
LRRK2 (rat) GQSDDLDSEGSESSF S894
S898
DDLDsEGsEGSFLVK
0 1
LRRK2 (human) DDLDsEGsEGSFLVK S898
LRRK2 (mouse) DDLDSEGSESSFLVK S898
LRRK2 (rat) DDLDSEGSESSFLVK S897
S908
SFLVKKKsNsIsVGE
0 5
LRRK2 (human) SFLVKKKsNsIsVGE S908
LRRK2 (mouse) SFLVKRKSNsIsVGE S908
LRRK2 (rat) SFLVKKKSNsVSVGE S907
S910
LVKKKsNsIsVGEFY
Upstream
Downstream
20 17
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
  • ubiquitination
Kinase, in vitro:
  • PKACA (human)
Phosphatases, in vitro:
  • PPP1CA (human)
Putative in vivo kinases:
  • LRRK2 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
  • PPP1CB (human)
  • PPP1CC (human)
  • PPP2CA (human)
Regulatory protein:
  • CDC25A (human)
  • CDC25B (human)
  • CDC25C (human)
  • NIPP-1 (human)
  • PKACA (human)
Treatment
  • arsenite
  • Bay_11-7082
  • Bay_11-7085
  • calyculin_A
  • colforsin
  • GNE1023
  • GSK2578215A
  • GW441756
  • H1152
  • H2O2
  • I-2
  • IBMX
  • IKK_inhibitor_VII
  • LRRK2-IN-1
  • mutation
  • NKH_477
  • NVP-TAE684
  • okadaic_acid
  • PD_407824
  • SB218078
  • serum_starvation
  • SP600125
  • sunitinib
LRRK2 (human) LVKKKsNsIsVGEFY S910
LRRK2 (mouse) LVKRKSNsIsVGEVY S910
LRRK2 (rat) LVKKKSNsVSVGEVY S909
S912
KKKsNsIsVGEFYRD
0 2
LRRK2 (human) KKKsNsIsVGEFYRD S912
LRRK2 (mouse) KRKSNsIsVGEVYRD S912
LRRK2 (rat) KKKSNsVSVGEVYRD S911
S926
DAVLQRCsPNLQRHs
1 1
LRRK2 (human) DAVLQRCsPNLQRHs S926
LRRK2 (mouse) DLALQRCSPNAQRHS S926
LRRK2 (rat) DLALQRCSPNAQRHS S925
S933
sPNLQRHsNsLGPIF
1 2
LRRK2 (human) sPNLQRHsNsLGPIF S933
LRRK2 (mouse) SPNAQRHSNsLGPVF S933
LRRK2 (rat) SPNAQRHSSSLGPVF S932
S935
NLQRHsNsLGPIFDH
Upstream
Downstream
35 19
LRRK2 (human)
S935
LRRK2 (mouse)
S935
Effects on Modified Protein
  • enzymatic activity, inhibited
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
  • ubiquitination
Kinase, in vitro:
  • LRRK2 (human)
  • PKACA (human)
Phosphatases, in vitro:
  • PPP1CA (human)
  • PPP2CA (human)
Putative in vivo kinases:
  • LRRK2 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
  • PPP1CB (human)
  • PPP1CC (human)
  • PPP2CA (human)
Regulatory protein:
  • CDC25A (human)
  • CDC25B (human)
  • CDC25C (human)
  • NIPP-1 (human)
  • PKACA (human)
  • RAB29 (human)
Treatment
  • arsenite
  • Bay_11-7082
  • Bay_11-7085
  • calyculin_A
  • Cmpd A
  • colforsin
  • coumpound_14
  • EB-42168
  • FX2149
  • GNE1023
  • GSK2578215A
  • GSK3357679A
  • GW441756
  • GZD824
  • H1152
  • H2O2
  • I-2
  • IBMX
  • IKK_inhibitor_VII
  • lactacystin
  • LP-935509
  • LRKK2-INH1
  • LRRK2-IN-1
  • Lu AF587896
  • MG132
  • MLI-2
  • mutation
  • NKH_477
  • NVP-TAE684
  • okadaic_acid
  • PD_407824
  • PF06447475
  • PFE-360
  • ponatinib
  • rebastinib
  • SB218078
  • serum_starvation
  • siRNA
  • SP600125
  • sunitinib
  • Y27632
LRRK2 (human) NLQRHsNsLGPIFDH S935
LRRK2 (mouse) NAQRHSNsLGPVFDH S935
LRRK2 (rat) NAQRHSSSLGPVFDH S934
S954
KRKRKILssDDsLRS
0 4
LRRK2 (human) KRKRKILssDDsLRS S954
LRRK2 (mouse) RRKRKILssDEsLRS S954
LRRK2 (rat) RRKRKILSSDESLRS S953
S955
RKRKILssDDsLRSs
Upstream
Downstream
13 7
Effects on Modified Protein
  • enzymatic activity, inhibited
  • phosphorylation
  • protein stabilization
  • ubiquitination
Phosphatases, in vitro:
  • PPP1CA (human)
Putative in vivo kinases:
  • LRRK2 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
  • PPP1CB (human)
  • PPP1CC (human)
  • PPP2CA (human)
Regulatory protein:
  • CDC25A (human)
  • CDC25B (human)
  • CDC25C (human)
  • NIPP-1 (human)
Treatment
  • Bay_11-7082
  • Bay_11-7085
  • calyculin_A
  • GNE1023
  • GSK2578215A
  • GW441756
  • H1152
  • I-2
  • IBMX
  • IKK_inhibitor_VII
  • LRRK2-IN-1
  • mutation
  • NKH_477
  • okadaic_acid
  • PD_407824
  • SB218078
  • serum_starvation
  • SP600125
  • sunitinib
LRRK2 (human) RKRKILssDDsLRSs S955
LRRK2 (mouse) RKRKILssDEsLRSS S955
LRRK2 (rat) RKRKILSSDESLRSS S954
S958
KILssDDsLRSsKLQ
0 4
LRRK2 (human) KILssDDsLRSsKLQ S958
LRRK2 (mouse) KILssDEsLRSSRLP S958
LRRK2 (rat) KILSSDESLRSSRLQ S957
S962
sDDsLRSsKLQSHMR
0 1
LRRK2 (human) sDDsLRSsKLQSHMR S962
LRRK2 (mouse) sDEsLRSSRLPSHMR S962
LRRK2 (rat) SDESLRSSRLQSHTR S961
S971
LQSHMRHsDsIssLA
0 4
LRRK2 (human) LQSHMRHsDsIssLA S971
LRRK2 (mouse) LPSHMRQSDsSSsLA S971
LRRK2 (rat) LQSHTRQSDSSSSLA S970
S973
SHMRHsDsIssLAsE
Upstream
Downstream
12 13
Effects on Modified Protein
  • enzymatic activity, inhibited
  • phosphorylation
  • protein stabilization
  • ubiquitination
Phosphatases, in vitro:
  • PPP1CA (human)
Putative in vivo kinases:
  • LRRK2 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
  • PPP1CB (human)
  • PPP1CC (human)
  • PPP2CA (human)
Regulatory protein:
  • CDC25A (human)
  • CDC25B (human)
  • CDC25C (human)
  • NIPP-1 (human)
  • RAB29 (human)
Treatment
  • Bay_11-7082
  • Bay_11-7085
  • calyculin_A
  • GNE1023
  • GSK2578215A
  • GW441756
  • GZD824
  • I-2
  • IBMX
  • IKK_inhibitor_VII
  • LRRK2-IN-1
  • mutation
  • NKH_477
  • okadaic_acid
  • PD_407824
  • SB218078
  • serum_starvation
  • SP600125
LRRK2 (human) SHMRHsDsIssLAsE S973
LRRK2 (mouse) SHMRQSDsSSsLASE S973
LRRK2 (rat) SHTRQSDSSSSLASE S972
S975
MRHsDsIssLAsERE
0 2
LRRK2 (human) MRHsDsIssLAsERE S975
LRRK2 (mouse) MRQSDsSSsLASERE S975
LRRK2 (rat) TRQSDSSSSLASERE S974
S976
RHsDsIssLAsEREY
2 6
LRRK2 (human) RHsDsIssLAsEREY S976
LRRK2 (mouse) RQSDsSSsLASEREH S976
LRRK2 (rat) RQSDSSSSLASEREH S975
S979
DsIssLAsEREYITS
0 2
LRRK2 (human) DsIssLAsEREYITS S979
LRRK2 (mouse) DsSSsLASEREHITS S979
LRRK2 (rat) DSSSSLASEREHITS S978
T1024
ELHQNALtsFPQQLC
0 1
LRRK2 (human) ELHQNALtsFPQQLC T1024
LRRK2 (mouse) ELHQNSLTSFPQQLC T1024
LRRK2 (rat) ELHQNSLTSFPQQLC T1023
S1025
LHQNALtsFPQQLCE
0 1
LRRK2 (human) LHQNALtsFPQQLCE S1025
LRRK2 (mouse) LHQNSLTSFPQQLCE S1025
LRRK2 (rat) LHQNSLTSFPQQLCE S1024
S1058
PSYLLKMsCIANLDV
0 2
LRRK2 (human) PSYLLKMsCIANLDV S1058
LRRK2 (mouse) PSFVLKMPRITNLDA P1058
LRRK2 (rat) PSFMLKMPSVIHLDA P1057
S1124
NKISGICsPLRLKEL
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) NKISGICsPLRLKEL S1124
LRRK2 (mouse) NKISGICSPLSLKEL S1124
LRRK2 (rat) NKISGICSPLSLKEL S1123
S1157
EACPKVEsFsARMNF
0 1
LRRK2 (human) EACPKVEsFsARMNF S1157
LRRK2 (mouse) EACSKVESFSARMNF S1157
LRRK2 (rat) EACPKVESFSARMNF S1156
S1159
CPKVEsFsARMNFLA
0 1
LRRK2 (human) CPKVEsFsARMNFLA S1159
LRRK2 (mouse) CSKVESFSARMNFLA S1159
LRRK2 (rat) CPKVESFSARMNFLA S1158
T1176
PFLPPSMtILKLSQN
0 1
LRRK2 (human) PFLPPSMtILKLSQN T1176
LRRK2 (mouse) PALPSSITSLKLSQN T1176
LRRK2 (rat) PALPSSITSLKLSQN T1175
S1219
PGPAHWKsLNLRELL
0 1
LRRK2 (human) PGPAHWKsLNLRELL S1219
LRRK2 (mouse) PGPAHWKSLNLRELI S1219
LRRK2 (rat) PGPAHWKSLNLRELI S1218
S1228
NLRELLFsHNQISIL
0 1
LRRK2 (human) NLRELLFsHNQISIL S1228
LRRK2 (mouse) NLRELIFSKNQISTL S1228
LRRK2 (rat) NLRELIFSKNQISTL S1227
S1253
RVEKLHLsHNKLKEI
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) RVEKLHLsHNKLKEI S1253
LRRK2 (mouse) RVEKLHLSHNKLKEI S1253
LRRK2 (rat) RVEKLHLSHNKLKEI S1252
S1283
SYNLELRsFPNEMGK
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) SYNLELRsFPNEMGK S1283
LRRK2 (mouse) SYNLELRSFPNEMGK S1283
LRRK2 (rat) SYNLELRSFPNEMGK S1282
S1292
PNEMGKLsKIWDLPL
Upstream
Downstream
7 3
LRRK2 (human)
S1292
LRRK2 (mouse)
S1292
LRRK2 (rat)
S1291
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
Effects on Biological Processes:
  • cell growth, induced
Kinase, in vitro:
  • LRRK2 (human)
Putative in vivo kinases:
  • LRRK2 (human)
Putative upstream phosphatases:
  • PPP1CA (human)
  • PPP2CA (human)
Regulatory protein:
  • RAB29 (human)
Treatment
  • calyculin_A
  • doxycycline
  • GSK3357679A
  • GZD824
  • IBMX
  • LRRK2-IN-1
  • MLI-2
  • NKH_477
  • okadaic_acid
  • serum_starvation
  • sunitinib
LRRK2 (human) PNEMGKLsKIWDLPL S1292
LRRK2 (mouse) PNEMGKLsKIWDLPL S1292
LRRK2 (rat) PNEMGKLSKIWDLPL S1291
Y1332
RLKKAVPyNRMKLMI
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) RLKKAVPyNRMKLMI Y1332
LRRK2 (mouse) RLKKAVPYNRMKLMI Y1332
LRRK2 (rat) RLKKAVPYNRMKLMI Y1331
T1343
KLMIVGNtGsGKttL
Upstream
Downstream
2 5
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KLMIVGNtGsGKttL T1343
LRRK2 (mouse) KLMIVGNTGSGKtTL T1343
LRRK2 (rat) KLMIVGNTGSGKTTL T1342
S1345
MIVGNtGsGKttLLQ
Upstream
0 3
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) MIVGNtGsGKttLLQ S1345
LRRK2 (mouse) MIVGNTGSGKtTLLQ S1345
LRRK2 (rat) MIVGNTGSGKTTLLQ S1344
T1348
GNtGsGKttLLQQLM
Upstream
Downstream
4 3
Effects on Modified Protein
  • molecular association, regulation
  • protein conformation
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) GNtGsGKttLLQQLM T1348
LRRK2 (mouse) GNTGSGKtTLLQQLM T1348
LRRK2 (rat) GNTGSGKTTLLQQLM T1347
T1349
NtGsGKttLLQQLMK
0 1
LRRK2 (human) NtGsGKttLLQQLMK T1349
LRRK2 (mouse) NTGSGKtTLLQQLMK T1349
LRRK2 (rat) NTGSGKTTLLQQLMK T1348
T1357
LLQQLMKtKKSDLGM
Upstream
2 3
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) LLQQLMKtKKSDLGM T1357
LRRK2 (mouse) LLQQLMKMKKPELGM M1357
LRRK2 (rat) LLQQLMKMKKSELGM M1356
T1368
DLGMQSAtVGIDVKD
Upstream
1 3
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) DLGMQSAtVGIDVKD T1368
LRRK2 (mouse) ELGMQGATVGIDVRD T1368
LRRK2 (rat) ELGMQGATVGIDVRD T1367
Y1402
FAGREEFystHPHFM
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) FAGREEFystHPHFM Y1402
LRRK2 (mouse) FAGREEFYSTHPHFM Y1402
LRRK2 (rat) FAGREEFYSTHPHFM Y1401
S1403
AGREEFystHPHFMt
Upstream
0 3
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) AGREEFystHPHFMt S1403
LRRK2 (mouse) AGREEFYSTHPHFMT S1403
LRRK2 (rat) AGREEFYSTHPHFMT S1402
T1404
GREEFystHPHFMtQ
Upstream
0 3
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) GREEFystHPHFMtQ T1404
LRRK2 (mouse) GREEFYSTHPHFMTQ T1404
LRRK2 (rat) GREEFYSTHPHFMTQ T1403
T1410
stHPHFMtQRALYLA
Upstream
Downstream
4 4
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • LRRK2 (human)
Putative in vivo kinases:
  • LRRK2 (human)
Treatment
  • arsenite
  • H2O2
  • LRRK2-IN-1
LRRK2 (human) stHPHFMtQRALYLA T1410
LRRK2 (mouse) STHPHFMTQRALYLA T1410
LRRK2 (rat) STHPHFMTQRALYLA T1409
S1443
FNIKARAsssPVILV
Upstream
1 2
Kinase, in vitro:
  • LRRK2 (human)
  • PKACA (human)
LRRK2 (human) FNIKARAsssPVILV S1443
LRRK2 (mouse) FNIKARASSSPVILV S1443
LRRK2 (rat) FNIKARASSSPVILV S1442
S1444
NIKARAsssPVILVG
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • LRRK2 (human)
  • PKACA (human)
LRRK2 (human) NIKARAsssPVILVG S1444
LRRK2 (mouse) NIKARASSSPVILVG S1444
LRRK2 (rat) NIKARASSSPVILVG S1443
S1445
IKARAsssPVILVGt
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) IKARAsssPVILVGt S1445
LRRK2 (mouse) IKARASSSPVILVGT S1445
LRRK2 (rat) IKARASSSPVILVGT S1444
T1452
sPVILVGtHLDVsDE
Upstream
0 3
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) sPVILVGtHLDVsDE T1452
LRRK2 (mouse) SPVILVGTHLDVSDE T1452
LRRK2 (rat) SPVILVGTHLDVSDE T1451
S1457
VGtHLDVsDEKQRKA
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) VGtHLDVsDEKQRKA S1457
LRRK2 (mouse) VGTHLDVSDEKQRKA S1457
LRRK2 (rat) VGTHLDVSDEKQRKA S1456
S1467
KQRKACMsKItKELL
Upstream
0 2
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KQRKACMsKItKELL S1467
LRRK2 (mouse) KQRKACISKITKELL S1467
LRRK2 (rat) KQRKACIGKITKELL G1466
T1470
KACMsKItKELLNKR
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KACMsKItKELLNKR T1470
LRRK2 (mouse) KACISKITKELLNKR T1470
LRRK2 (rat) KACIGKITKELLNKR T1469
Y1485
GFPAIRDyHFVNAtE
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) GFPAIRDyHFVNAtE Y1485
LRRK2 (mouse) GFPTIRDYHFVNATE Y1485
LRRK2 (rat) GFPTIRDYHFVNATE Y1484
T1491
DyHFVNAtEESDALA
Upstream
Downstream
5 5
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) DyHFVNAtEESDALA T1491
LRRK2 (mouse) DYHFVNATEESDALA T1491
LRRK2 (rat) DYHFVNATEESDALA T1490
T1503
ALAKLRKtIINEsLN
Upstream
Downstream
6 4
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
Kinase, in vitro:
  • LRRK2 (human)
Putative in vivo kinases:
  • LRRK2 (human)
LRRK2 (human) ALAKLRKtIINEsLN T1503
LRRK2 (mouse) ALAKLRKTIINESLN T1503
LRRK2 (rat) ALAKLRKTIINESLN T1502
S1508
RKtIINEsLNFKIRD
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) RKtIINEsLNFKIRD S1508
LRRK2 (mouse) RKTIINESLNFKIRD S1508
LRRK2 (rat) RKTIINESLNFKIRD S1507
S1536
ELEKIILsERKNVPI
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) ELEKIILsERKNVPI S1536
LRRK2 (mouse) ELEKIILSERKAVPT S1536
LRRK2 (rat) ELEKIILSERKAVPT S1535
T1612
KIMAQILtVKVEGCP
Upstream
0 2
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KIMAQILtVKVEGCP T1612
LRRK2 (mouse) KVMAQILTVKVDGCL T1612
LRRK2 (rat) KVMAQILTVKVDGCL T1611
S1627
KHPKGIIsRRDVEKF
Upstream
1 0
Kinase, in vitro:
  • CDK5 (human)
Putative in vivo kinases:
  • CDK5 (human)
LRRK2 (human) KHPKGIIsRRDVEKF S1627
LRRK2 (mouse) KHPKGIISRRDVEKF S1627
LRRK2 (rat) KHPKGIISRRDVEKF S1626
S1647
KFPKNYMsQYFKLLE
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KFPKNYMsQYFKLLE S1647
LRRK2 (mouse) RFPKNYMMQYFKLLE M1647
LRRK2 (rat) RFPKNYMAQYFKLLE A1646
S1716
INRLLEISPyMLsGR
0 1
LRRK2 (human) INRLLEISPyMLsGR S1716
LRRK2 (mouse) INRLLEIsPFMLSGR S1716
LRRK2 (rat) INRLLEISPFMLSGR S1715
Y1718
RLLEISPyMLsGRER
0 1
LRRK2 (human) RLLEISPyMLsGRER Y1718
LRRK2 (mouse) RLLEIsPFMLSGRER F1718
LRRK2 (rat) RLLEISPFMLSGRER F1717
S1721
EISPyMLsGRERALR
0 1
LRRK2 (human) EISPyMLsGRERALR S1721
LRRK2 (mouse) EIsPFMLSGRERALR S1721
LRRK2 (rat) EISPFMLSGRERALR S1720
T1849
NPDQPRLtIPIsQIA
Upstream
0 2
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) NPDQPRLtIPIsQIA T1849
LRRK2 (mouse) NPDQPRLTIPISQIA T1849
LRRK2 (rat) NPDQPRLTIPISQIA T1848
S1853
PRLtIPIsQIAPDLI
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) PRLtIPIsQIAPDLI S1853
LRRK2 (mouse) PRLTIPISQIAPDLI S1853
LRRK2 (rat) PRLTIPISQIAPDLI S1852
T1912
VKIFNKHtsLRLLRQ
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) VKIFNKHtsLRLLRQ T1912
LRRK2 (mouse) VKIFNKHTSLRLLRQ T1912
LRRK2 (rat) VKIFNKHTSLRLLRQ T1911
S1913
KIFNKHtsLRLLRQE
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) KIFNKHtsLRLLRQE S1913
LRRK2 (mouse) KIFNKHTSLRLLRQE S1913
LRRK2 (rat) KIFNKHTSLRLLRQE S1912
T1967
QQDKASLtRtLQHRI
Upstream
0 2
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) QQDKASLtRtLQHRI T1967
LRRK2 (mouse) QQDKASLTRTLQHRI T1967
LRRK2 (rat) QQDKASLTRTLQHRI T1966
T1969
DKASLtRtLQHRIAL
Upstream
0 2
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) DKASLtRtLQHRIAL T1969
LRRK2 (mouse) DKASLTRTLQHRIAL T1969
LRRK2 (rat) DKASLTRTLQHRIAL T1968
Y2023
ADyGIAQyCCRMGIK
0 7
LRRK2 (human) ADyGIAQyCCRMGIK Y2023
LRRK2 (mouse) ADYGIAQYCCRMGIK Y2023
LRRK2 (rat) ADYGIAQYCCRMGIK Y2022
T2031
CCRMGIKtsEGtPGF
Upstream
3 2
Kinase, in vitro:
  • LRRK2 (human)
Treatment
  • H2O2
LRRK2 (human) CCRMGIKtsEGtPGF T2031
LRRK2 (mouse) CCRMGIKTSEGTPGF T2031
LRRK2 (rat) CCRMGIKTSEGTPGF T2030
S2032
CRMGIKtsEGtPGFR
Upstream
Downstream
4 2
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • LRRK2 (human)
Treatment
  • FX2149
  • H2O2
LRRK2 (human) CRMGIKtsEGtPGFR S2032
LRRK2 (mouse) CRMGIKTSEGTPGFR S2032
LRRK2 (rat) CRMGIKTSEGTPGFR S2031
T2035
GIKtsEGtPGFRAPE
Upstream
Downstream
4 1
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • LRRK2 (human)
Treatment
  • H2O2
LRRK2 (human) GIKtsEGtPGFRAPE T2035
LRRK2 (mouse) GIKTSEGTPGFRAPE T2035
LRRK2 (rat) GIKTSEGTPGFRAPE T2034
S2166
HHNSRNAsIWLGCGH
0 1
LRRK2 (human) HHNSRNAsIWLGCGH S2166
LRRK2 (mouse) NLNSKSATLWLGCGN T2166
LRRK2 (rat) NLNSKRATLWLGCGN T2165
T2237
EDGKKRHtLEKMTDS
0 1
LRRK2 (human) EDGKKRHtLEKMTDS T2237
LRRK2 (mouse) EEETKRHTLEKMTDS T2237
LRRK2 (rat) EDETRRHTLDKMTDS T2236
S2257
CNSFSKQsKQKNFLL
Upstream
0 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) CNSFSKQsKQKNFLL S2257
LRRK2 (mouse) CNSLAKQSKQSNFLL S2257
LRRK2 (rat) CNSFAKQSKQSHFLL S2256
Y2449
RRLIRVIyNFCNSVR
0 1
LRRK2 (human) RRLIRVIyNFCNSVR Y2449
LRRK2 (mouse) RRVIRTIHNFCDSVR H2449
LRRK2 (rat) RRVIRTIHNFCDSVR H2448
T2460
NSVRVMMtAQLGSLK
0 1
LRRK2 (human) NSVRVMMtAQLGSLK T2460
LRRK2 (mouse) DSVRAMATAQLGSLK T2460
LRRK2 (rat) DSVRAMATAQLGNLK T2459
T2483
NRKNTEGtQKQKEIQ
Upstream
2 1
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) NRKNTEGtQKQKEIQ T2483
LRRK2 (mouse) KRKSTEGIQEQKEIQ I2483
LRRK2 (rat) KRKSTEGTQEQKEIQ T2482
T2524
LAEKMRRtSVE____
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • LRRK2 (human)
LRRK2 (human) LAEKMRRtSVE____ T2524
LRRK2 (mouse) LADKMRKTSVE____ T2524
LRRK2 (rat) LADKMRKTSVE____ T2523
Y2018
IIAKIADyGIAQyCC
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
LRRK2 (human) IIAKIADyGIAQyCC Y2018
LRRK2 (mouse) IIAKIADYGIAQYCC Y2018
LRRK2 (rat) IIAKIADYGIAQYCC Y2017