LRRK2 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

_____MAsGsCQGCE

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	_____MAsGsCQGCE	S3
LRRK2 (mouse)	_____MASGACQGCE	S3
LRRK2 (rat)	_____MASGACQGCD	S3

___MAsGsCQGCEED

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	___MAsGsCQGCEED	S5
LRRK2 (mouse)	___MASGACQGCEEE	A5
LRRK2 (rat)	___MASGACQGCDEE	A5

T358

EACYKALtWHRKNKH

LRRK2 (human)	EACYKALtWHRKNKH	T358
LRRK2 (mouse)	EPCYKALVRHRKDKH	V360
LRRK2 (rat)	EPCYKALMRHRKNKH	M359

T424

ASANALStLLEQNVN

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	ASANALStLLEQNVN	T424
LRRK2 (mouse)	AAAHALSTLLEQNVN	T426
LRRK2 (rat)	AAAHALSTLLEQNVN	T425

T489

AVVPKILtVMKRHEt

LRRK2 (human)	AVVPKILtVMKRHEt	T489
LRRK2 (mouse)	AVVPKILTVMKAHGT	T491
LRRK2 (rat)	AVIPKILTVMRTHGT	T490

T496

tVMKRHEtSLPVQLE

LRRK2 (human)	tVMKRHEtSLPVQLE	T496
LRRK2 (mouse)	TVMKAHGTSLSVQLE	T498
LRRK2 (rat)	TVMRTHGTSLSVQLE	T497

T524

PEESREDtEFHHKLN

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	PEESREDtEFHHKLN	T524
LRRK2 (mouse)	LEESREDSQCRPNVL	S526
LRRK2 (rat)	SEDSRDDSRCQPNVL	S525

S633

LLAKILVssLyRFKD

LRRK2 (human)	LLAKILVssLyRFKD	S633
LRRK2 (mouse)	LLAKILASTLQRFKD	S633
LRRK2 (rat)	LLAKILASTLQRFKD	S632

S634

LAKILVssLyRFKDV

LRRK2 (human)	LAKILVssLyRFKDV	S634
LRRK2 (mouse)	LAKILASTLQRFKDV	T634
LRRK2 (rat)	LAKILASTLQRFKDV	T633

Y636

KILVssLyRFKDVAE

LRRK2 (human)	KILVssLyRFKDVAE	Y636
LRRK2 (mouse)	KILASTLQRFKDVAE	Q636
LRRK2 (rat)	KILASTLQRFKDVAE	Q635

Y707

AKVAMDDyLKNVMLE

LRRK2 (human)	AKVAMDDyLKNVMLE	Y707
LRRK2 (mouse)	AKVAVDDELKNTMLE	E707
LRRK2 (rat)	AKVAVDDELKSKMLE	E706

T776

QDVRKALtISIGKGD

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	QDVRKALtISIGKGD	T776
LRRK2 (mouse)	QDVRKALTVSIQKGD	T776
LRRK2 (rat)	QDVRKALTVSIQKGD	T775

S784

ISIGKGDsQIIsLLL

LRRK2 (human)	ISIGKGDsQIIsLLL	S784
LRRK2 (mouse)	VSIQKGDSQVISLLL	S784
LRRK2 (rat)	VSIQKGDNQVISLLL	N783

S788

KGDsQIIsLLLRRLA

LRRK2 (human)	KGDsQIIsLLLRRLA	S788
LRRK2 (mouse)	KGDSQVISLLLRKLA	S788
LRRK2 (rat)	KGDNQVISLLLRRLA	S787

T826

GPLFPDKtSNLRKQt

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	GPLFPDKtSNLRKQt	T826
LRRK2 (mouse)	GPLFPDKSSNLRKQT	S826
LRRK2 (rat)	GPLFPDKSSNLRKQT	S825

T833

tSNLRKQtNIAstLA

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	tSNLRKQtNIAstLA	T833
LRRK2 (mouse)	SSNLRKQTNTGSVLA	T833
LRRK2 (rat)	SSNLRKQTNAGSVLA	T832

S837

RKQtNIAstLARMVI

LRRK2 (human)	RKQtNIAstLARMVI	S837
LRRK2 (mouse)	RKQTNTGSVLARKVL	S837
LRRK2 (rat)	RKQTNAGSVLARKVL	S836

T838

KQtNIAstLARMVIR

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KQtNIAstLARMVIR	T838
LRRK2 (mouse)	KQTNTGSVLARKVLR	V838
LRRK2 (rat)	KQTNAGSVLARKVLR	V837

S850

VIRYQMKsAVEEGTA

LRRK2 (human)	VIRYQMKsAVEEGTA	S850
LRRK2 (mouse)	VLRYQMRNTLQEGVA	N850
LRRK2 (rat)	VLRYQMRNTLQEGVA	N849

S858

AVEEGTAsGsDGNFs

LRRK2 (human)	AVEEGTAsGsDGNFs	S858
LRRK2 (mouse)	TLQEGVASGsDGKFS	S858
LRRK2 (rat)	TLQEGVASGSEGNFS	S857

S860

EEGTAsGsDGNFsED

LRRK2 (human)	EEGTAsGsDGNFsED	S860
LRRK2 (mouse)	QEGVASGsDGKFSED	S860
LRRK2 (rat)	QEGVASGSEGNFSED	S859

S865

sGsDGNFsEDVLSKF

LRRK2 (human)	sGsDGNFsEDVLSKF	S865
LRRK2 (mouse)	SGsDGKFSEDALAKF	S865
LRRK2 (rat)	SGSEGNFSEDALAKF	S864

S895

AQSDDLDsEGsEGSF

LRRK2 (human)	AQSDDLDsEGsEGSF	S895
LRRK2 (mouse)	GQSDDLDSEGSESSF	S895
LRRK2 (rat)	GQSDDLDSEGSESSF	S894

S898

DDLDsEGsEGSFLVK

LRRK2 (human)	DDLDsEGsEGSFLVK	S898
LRRK2 (mouse)	DDLDSEGSESSFLVK	S898
LRRK2 (rat)	DDLDSEGSESSFLVK	S897

S908

SFLVKKKsNsIsVGE

LRRK2 (human)	SFLVKKKsNsIsVGE	S908
LRRK2 (mouse)	SFLVKRKSNsIsVGE	S908
LRRK2 (rat)	SFLVKKKSNsVSVGE	S907

S910

LVKKKsNsIsVGEFY

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, inhibited
intracellular localization
molecular association, regulation
phosphorylation
protein stabilization
ubiquitination

Kinase, in vitro:

PKACA (human)

Phosphatases, in vitro:

PPP1CA (human)

Putative in vivo kinases:

LRRK2 (human)

Putative upstream phosphatases:

PPP1CA (human)
PPP1CB (human)
PPP1CC (human)
PPP2CA (human)

Regulatory protein:

CDC25A (human)
CDC25B (human)
CDC25C (human)
NIPP-1 (human)
PKACA (human)

Treatment

arsenite
Bay_11-7082
Bay_11-7085
calyculin_A
colforsin
GNE1023
GSK2578215A
GW441756
H1152
H2O2
I-2
IBMX
IKK_inhibitor_VII
LRRK2-IN-1
mutation
NKH_477
NVP-TAE684
okadaic_acid
PD_407824
SB218078
serum_starvation
SP600125
sunitinib

LRRK2 (human)	LVKKKsNsIsVGEFY	S910
LRRK2 (mouse)	LVKRKSNsIsVGEVY	S910
LRRK2 (rat)	LVKKKSNsVSVGEVY	S909

S912

KKKsNsIsVGEFYRD

LRRK2 (human)	KKKsNsIsVGEFYRD	S912
LRRK2 (mouse)	KRKSNsIsVGEVYRD	S912
LRRK2 (rat)	KKKSNsVSVGEVYRD	S911

S926

DAVLQRCsPNLQRHs

LRRK2 (human)	DAVLQRCsPNLQRHs	S926
LRRK2 (mouse)	DLALQRCSPNAQRHS	S926
LRRK2 (rat)	DLALQRCSPNAQRHS	S925

S933

sPNLQRHsNsLGPIF

LRRK2 (human)	sPNLQRHsNsLGPIF	S933
LRRK2 (mouse)	SPNAQRHSNsLGPVF	S933
LRRK2 (rat)	SPNAQRHSSSLGPVF	S932

S935

NLQRHsNsLGPIFDH

Upstream

Downstream

LRRK2 (human)
S935

59576 : Phospho-LRRK2 (Ser935) Antibody

LRRK2 (mouse)
S935

59576 : Phospho-LRRK2 (Ser935) Antibody

Effects on Modified Protein

enzymatic activity, inhibited
intracellular localization
molecular association, regulation
phosphorylation
protein stabilization
ubiquitination

Kinase, in vitro:

LRRK2 (human)
PKACA (human)

Phosphatases, in vitro:

PPP1CA (human)
PPP2CA (human)

Putative in vivo kinases:

LRRK2 (human)

Putative upstream phosphatases:

PPP1CA (human)
PPP1CB (human)
PPP1CC (human)
PPP2CA (human)

Regulatory protein:

CDC25A (human)
CDC25B (human)
CDC25C (human)
NIPP-1 (human)
PKACA (human)
RAB29 (human)

Treatment

arsenite
Bay_11-7082
Bay_11-7085
calyculin_A
Cmpd A
colforsin
coumpound_14
EB-42168
FX2149
GNE1023
GSK2578215A
GSK3357679A
GW441756
GZD824
H1152
H2O2
I-2
IBMX
IKK_inhibitor_VII
lactacystin
LP-935509
LRKK2-INH1
LRRK2-IN-1
Lu AF587896
MG132
MLI-2
mutation
NKH_477
NVP-TAE684
okadaic_acid
PD_407824
PF06447475
PFE-360
ponatinib
rebastinib
SB218078
serum_starvation
siRNA
SP600125
sunitinib
Y27632

LRRK2 (human)	NLQRHsNsLGPIFDH	S935
LRRK2 (mouse)	NAQRHSNsLGPVFDH	S935
LRRK2 (rat)	NAQRHSSSLGPVFDH	S934

S954

KRKRKILssDDsLRS

LRRK2 (human)	KRKRKILssDDsLRS	S954
LRRK2 (mouse)	RRKRKILssDEsLRS	S954
LRRK2 (rat)	RRKRKILSSDESLRS	S953

S955

RKRKILssDDsLRSs

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, inhibited
phosphorylation
protein stabilization
ubiquitination

Phosphatases, in vitro:

PPP1CA (human)

Putative in vivo kinases:

LRRK2 (human)

Putative upstream phosphatases:

PPP1CA (human)
PPP1CB (human)
PPP1CC (human)
PPP2CA (human)

Regulatory protein:

CDC25A (human)
CDC25B (human)
CDC25C (human)
NIPP-1 (human)

Treatment

Bay_11-7082
Bay_11-7085
calyculin_A
GNE1023
GSK2578215A
GW441756
H1152
I-2
IBMX
IKK_inhibitor_VII
LRRK2-IN-1
mutation
NKH_477
okadaic_acid
PD_407824
SB218078
serum_starvation
SP600125
sunitinib

LRRK2 (human)	RKRKILssDDsLRSs	S955
LRRK2 (mouse)	RKRKILssDEsLRSS	S955
LRRK2 (rat)	RKRKILSSDESLRSS	S954

S958

KILssDDsLRSsKLQ

LRRK2 (human)	KILssDDsLRSsKLQ	S958
LRRK2 (mouse)	KILssDEsLRSSRLP	S958
LRRK2 (rat)	KILSSDESLRSSRLQ	S957

S962

sDDsLRSsKLQSHMR

LRRK2 (human)	sDDsLRSsKLQSHMR	S962
LRRK2 (mouse)	sDEsLRSSRLPSHMR	S962
LRRK2 (rat)	SDESLRSSRLQSHTR	S961

S971

LQSHMRHsDsIssLA

LRRK2 (human)	LQSHMRHsDsIssLA	S971
LRRK2 (mouse)	LPSHMRQSDsSSsLA	S971
LRRK2 (rat)	LQSHTRQSDSSSSLA	S970

S973

SHMRHsDsIssLAsE

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, inhibited
phosphorylation
protein stabilization
ubiquitination

Phosphatases, in vitro:

PPP1CA (human)

Putative in vivo kinases:

LRRK2 (human)

Putative upstream phosphatases:

PPP1CA (human)
PPP1CB (human)
PPP1CC (human)
PPP2CA (human)

Regulatory protein:

CDC25A (human)
CDC25B (human)
CDC25C (human)
NIPP-1 (human)
RAB29 (human)

Treatment

Bay_11-7082
Bay_11-7085
calyculin_A
GNE1023
GSK2578215A
GW441756
GZD824
I-2
IBMX
IKK_inhibitor_VII
LRRK2-IN-1
mutation
NKH_477
okadaic_acid
PD_407824
SB218078
serum_starvation
SP600125

LRRK2 (human)	SHMRHsDsIssLAsE	S973
LRRK2 (mouse)	SHMRQSDsSSsLASE	S973
LRRK2 (rat)	SHTRQSDSSSSLASE	S972

S975

MRHsDsIssLAsERE

LRRK2 (human)	MRHsDsIssLAsERE	S975
LRRK2 (mouse)	MRQSDsSSsLASERE	S975
LRRK2 (rat)	TRQSDSSSSLASERE	S974

S976

RHsDsIssLAsEREY

LRRK2 (human)	RHsDsIssLAsEREY	S976
LRRK2 (mouse)	RQSDsSSsLASEREH	S976
LRRK2 (rat)	RQSDSSSSLASEREH	S975

S979

DsIssLAsEREYITS

LRRK2 (human)	DsIssLAsEREYITS	S979
LRRK2 (mouse)	DsSSsLASEREHITS	S979
LRRK2 (rat)	DSSSSLASEREHITS	S978

T1024

ELHQNALtsFPQQLC

LRRK2 (human)	ELHQNALtsFPQQLC	T1024
LRRK2 (mouse)	ELHQNSLTSFPQQLC	T1024
LRRK2 (rat)	ELHQNSLTSFPQQLC	T1023

S1025

LHQNALtsFPQQLCE

LRRK2 (human)	LHQNALtsFPQQLCE	S1025
LRRK2 (mouse)	LHQNSLTSFPQQLCE	S1025
LRRK2 (rat)	LHQNSLTSFPQQLCE	S1024

S1058

PSYLLKMsCIANLDV

LRRK2 (human)	PSYLLKMsCIANLDV	S1058
LRRK2 (mouse)	PSFVLKMPRITNLDA	P1058
LRRK2 (rat)	PSFMLKMPSVIHLDA	P1057

S1124

NKISGICsPLRLKEL

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	NKISGICsPLRLKEL	S1124
LRRK2 (mouse)	NKISGICSPLSLKEL	S1124
LRRK2 (rat)	NKISGICSPLSLKEL	S1123

S1157

EACPKVEsFsARMNF

LRRK2 (human)	EACPKVEsFsARMNF	S1157
LRRK2 (mouse)	EACSKVESFSARMNF	S1157
LRRK2 (rat)	EACPKVESFSARMNF	S1156

S1159

CPKVEsFsARMNFLA

LRRK2 (human)	CPKVEsFsARMNFLA	S1159
LRRK2 (mouse)	CSKVESFSARMNFLA	S1159
LRRK2 (rat)	CPKVESFSARMNFLA	S1158

T1176

PFLPPSMtILKLSQN

LRRK2 (human)	PFLPPSMtILKLSQN	T1176
LRRK2 (mouse)	PALPSSITSLKLSQN	T1176
LRRK2 (rat)	PALPSSITSLKLSQN	T1175

S1219

PGPAHWKsLNLRELL

LRRK2 (human)	PGPAHWKsLNLRELL	S1219
LRRK2 (mouse)	PGPAHWKSLNLRELI	S1219
LRRK2 (rat)	PGPAHWKSLNLRELI	S1218

S1228

NLRELLFsHNQISIL

LRRK2 (human)	NLRELLFsHNQISIL	S1228
LRRK2 (mouse)	NLRELIFSKNQISTL	S1228
LRRK2 (rat)	NLRELIFSKNQISTL	S1227

S1253

RVEKLHLsHNKLKEI

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	RVEKLHLsHNKLKEI	S1253
LRRK2 (mouse)	RVEKLHLSHNKLKEI	S1253
LRRK2 (rat)	RVEKLHLSHNKLKEI	S1252

S1283

SYNLELRsFPNEMGK

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	SYNLELRsFPNEMGK	S1283
LRRK2 (mouse)	SYNLELRSFPNEMGK	S1283
LRRK2 (rat)	SYNLELRSFPNEMGK	S1282

S1292

PNEMGKLsKIWDLPL

Upstream

Downstream

LRRK2 (human)
S1292

65837 : Phospho-LRRK2 (Ser1292) (E8M3A) Rabbit mAb

LRRK2 (mouse)
S1292

65837 : Phospho-LRRK2 (Ser1292) (E8M3A) Rabbit mAb

LRRK2 (rat)
S1291

65837 : Phospho-LRRK2 (Ser1292) (E8M3A) Rabbit mAb

Effects on Modified Protein

enzymatic activity, induced
intracellular localization

Effects on Biological Processes:

cell growth, induced

Kinase, in vitro:

LRRK2 (human)

Putative in vivo kinases:

LRRK2 (human)

Putative upstream phosphatases:

PPP1CA (human)
PPP2CA (human)

Regulatory protein:

RAB29 (human)

Treatment

calyculin_A
doxycycline
GSK3357679A
GZD824
IBMX
LRRK2-IN-1
MLI-2
NKH_477
okadaic_acid
serum_starvation
sunitinib

LRRK2 (human)	PNEMGKLsKIWDLPL	S1292
LRRK2 (mouse)	PNEMGKLsKIWDLPL	S1292
LRRK2 (rat)	PNEMGKLSKIWDLPL	S1291

Y1332

RLKKAVPyNRMKLMI

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	RLKKAVPyNRMKLMI	Y1332
LRRK2 (mouse)	RLKKAVPYNRMKLMI	Y1332
LRRK2 (rat)	RLKKAVPYNRMKLMI	Y1331

T1343

KLMIVGNtGsGKttL

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein conformation

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KLMIVGNtGsGKttL	T1343
LRRK2 (mouse)	KLMIVGNTGSGKtTL	T1343
LRRK2 (rat)	KLMIVGNTGSGKTTL	T1342

S1345

MIVGNtGsGKttLLQ

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	MIVGNtGsGKttLLQ	S1345
LRRK2 (mouse)	MIVGNTGSGKtTLLQ	S1345
LRRK2 (rat)	MIVGNTGSGKTTLLQ	S1344

T1348

GNtGsGKttLLQQLM

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation
protein conformation

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	GNtGsGKttLLQQLM	T1348
LRRK2 (mouse)	GNTGSGKtTLLQQLM	T1348
LRRK2 (rat)	GNTGSGKTTLLQQLM	T1347

T1349

NtGsGKttLLQQLMK

LRRK2 (human)	NtGsGKttLLQQLMK	T1349
LRRK2 (mouse)	NTGSGKtTLLQQLMK	T1349
LRRK2 (rat)	NTGSGKTTLLQQLMK	T1348

T1357

LLQQLMKtKKSDLGM

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	LLQQLMKtKKSDLGM	T1357
LRRK2 (mouse)	LLQQLMKMKKPELGM	M1357
LRRK2 (rat)	LLQQLMKMKKSELGM	M1356

T1368

DLGMQSAtVGIDVKD

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	DLGMQSAtVGIDVKD	T1368
LRRK2 (mouse)	ELGMQGATVGIDVRD	T1368
LRRK2 (rat)	ELGMQGATVGIDVRD	T1367

Y1402

FAGREEFystHPHFM

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	FAGREEFystHPHFM	Y1402
LRRK2 (mouse)	FAGREEFYSTHPHFM	Y1402
LRRK2 (rat)	FAGREEFYSTHPHFM	Y1401

S1403

AGREEFystHPHFMt

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	AGREEFystHPHFMt	S1403
LRRK2 (mouse)	AGREEFYSTHPHFMT	S1403
LRRK2 (rat)	AGREEFYSTHPHFMT	S1402

T1404

GREEFystHPHFMtQ

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	GREEFystHPHFMtQ	T1404
LRRK2 (mouse)	GREEFYSTHPHFMTQ	T1404
LRRK2 (rat)	GREEFYSTHPHFMTQ	T1403

T1410

stHPHFMtQRALYLA

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation

Kinase, in vitro:

LRRK2 (human)

Putative in vivo kinases:

LRRK2 (human)

Treatment

arsenite
H2O2
LRRK2-IN-1

LRRK2 (human)	stHPHFMtQRALYLA	T1410
LRRK2 (mouse)	STHPHFMTQRALYLA	T1410
LRRK2 (rat)	STHPHFMTQRALYLA	T1409

S1443

FNIKARAsssPVILV

Upstream

Kinase, in vitro:

LRRK2 (human)
PKACA (human)

LRRK2 (human)	FNIKARAsssPVILV	S1443
LRRK2 (mouse)	FNIKARASSSPVILV	S1443
LRRK2 (rat)	FNIKARASSSPVILV	S1442

S1444

NIKARAsssPVILVG

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation

Kinase, in vitro:

LRRK2 (human)
PKACA (human)

LRRK2 (human)	NIKARAsssPVILVG	S1444
LRRK2 (mouse)	NIKARASSSPVILVG	S1444
LRRK2 (rat)	NIKARASSSPVILVG	S1443

S1445

IKARAsssPVILVGt

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	IKARAsssPVILVGt	S1445
LRRK2 (mouse)	IKARASSSPVILVGT	S1445
LRRK2 (rat)	IKARASSSPVILVGT	S1444

T1452

sPVILVGtHLDVsDE

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	sPVILVGtHLDVsDE	T1452
LRRK2 (mouse)	SPVILVGTHLDVSDE	T1452
LRRK2 (rat)	SPVILVGTHLDVSDE	T1451

S1457

VGtHLDVsDEKQRKA

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	VGtHLDVsDEKQRKA	S1457
LRRK2 (mouse)	VGTHLDVSDEKQRKA	S1457
LRRK2 (rat)	VGTHLDVSDEKQRKA	S1456

S1467

KQRKACMsKItKELL

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KQRKACMsKItKELL	S1467
LRRK2 (mouse)	KQRKACISKITKELL	S1467
LRRK2 (rat)	KQRKACIGKITKELL	G1466

T1470

KACMsKItKELLNKR

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KACMsKItKELLNKR	T1470
LRRK2 (mouse)	KACISKITKELLNKR	T1470
LRRK2 (rat)	KACIGKITKELLNKR	T1469

Y1485

GFPAIRDyHFVNAtE

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	GFPAIRDyHFVNAtE	Y1485
LRRK2 (mouse)	GFPTIRDYHFVNATE	Y1485
LRRK2 (rat)	GFPTIRDYHFVNATE	Y1484

T1491

DyHFVNAtEESDALA

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	DyHFVNAtEESDALA	T1491
LRRK2 (mouse)	DYHFVNATEESDALA	T1491
LRRK2 (rat)	DYHFVNATEESDALA	T1490

T1503

ALAKLRKtIINEsLN

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
molecular association, regulation
protein conformation

Kinase, in vitro:

LRRK2 (human)

Putative in vivo kinases:

LRRK2 (human)

LRRK2 (human)	ALAKLRKtIINEsLN	T1503
LRRK2 (mouse)	ALAKLRKTIINESLN	T1503
LRRK2 (rat)	ALAKLRKTIINESLN	T1502

S1508

RKtIINEsLNFKIRD

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	RKtIINEsLNFKIRD	S1508
LRRK2 (mouse)	RKTIINESLNFKIRD	S1508
LRRK2 (rat)	RKTIINESLNFKIRD	S1507

S1536

ELEKIILsERKNVPI

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	ELEKIILsERKNVPI	S1536
LRRK2 (mouse)	ELEKIILSERKAVPT	S1536
LRRK2 (rat)	ELEKIILSERKAVPT	S1535

T1612

KIMAQILtVKVEGCP

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KIMAQILtVKVEGCP	T1612
LRRK2 (mouse)	KVMAQILTVKVDGCL	T1612
LRRK2 (rat)	KVMAQILTVKVDGCL	T1611

S1627

KHPKGIIsRRDVEKF

Upstream

Kinase, in vitro:

CDK5 (human)

Putative in vivo kinases:

CDK5 (human)

LRRK2 (human)	KHPKGIIsRRDVEKF	S1627
LRRK2 (mouse)	KHPKGIISRRDVEKF	S1627
LRRK2 (rat)	KHPKGIISRRDVEKF	S1626

S1647

KFPKNYMsQYFKLLE

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KFPKNYMsQYFKLLE	S1647
LRRK2 (mouse)	RFPKNYMMQYFKLLE	M1647
LRRK2 (rat)	RFPKNYMAQYFKLLE	A1646

S1716

INRLLEISPyMLsGR

LRRK2 (human)	INRLLEISPyMLsGR	S1716
LRRK2 (mouse)	INRLLEIsPFMLSGR	S1716
LRRK2 (rat)	INRLLEISPFMLSGR	S1715

Y1718

RLLEISPyMLsGRER

LRRK2 (human)	RLLEISPyMLsGRER	Y1718
LRRK2 (mouse)	RLLEIsPFMLSGRER	F1718
LRRK2 (rat)	RLLEISPFMLSGRER	F1717

S1721

EISPyMLsGRERALR

LRRK2 (human)	EISPyMLsGRERALR	S1721
LRRK2 (mouse)	EIsPFMLSGRERALR	S1721
LRRK2 (rat)	EISPFMLSGRERALR	S1720

T1849

NPDQPRLtIPIsQIA

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	NPDQPRLtIPIsQIA	T1849
LRRK2 (mouse)	NPDQPRLTIPISQIA	T1849
LRRK2 (rat)	NPDQPRLTIPISQIA	T1848

S1853

PRLtIPIsQIAPDLI

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	PRLtIPIsQIAPDLI	S1853
LRRK2 (mouse)	PRLTIPISQIAPDLI	S1853
LRRK2 (rat)	PRLTIPISQIAPDLI	S1852

T1912

VKIFNKHtsLRLLRQ

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	VKIFNKHtsLRLLRQ	T1912
LRRK2 (mouse)	VKIFNKHTSLRLLRQ	T1912
LRRK2 (rat)	VKIFNKHTSLRLLRQ	T1911

S1913

KIFNKHtsLRLLRQE

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	KIFNKHtsLRLLRQE	S1913
LRRK2 (mouse)	KIFNKHTSLRLLRQE	S1913
LRRK2 (rat)	KIFNKHTSLRLLRQE	S1912

T1967

QQDKASLtRtLQHRI

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	QQDKASLtRtLQHRI	T1967
LRRK2 (mouse)	QQDKASLTRTLQHRI	T1967
LRRK2 (rat)	QQDKASLTRTLQHRI	T1966

T1969

DKASLtRtLQHRIAL

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	DKASLtRtLQHRIAL	T1969
LRRK2 (mouse)	DKASLTRTLQHRIAL	T1969
LRRK2 (rat)	DKASLTRTLQHRIAL	T1968

Y2023

ADyGIAQyCCRMGIK

LRRK2 (human)	ADyGIAQyCCRMGIK	Y2023
LRRK2 (mouse)	ADYGIAQYCCRMGIK	Y2023
LRRK2 (rat)	ADYGIAQYCCRMGIK	Y2022

T2031

CCRMGIKtsEGtPGF

Upstream

Kinase, in vitro:

LRRK2 (human)

Treatment

H2O2

LRRK2 (human)	CCRMGIKtsEGtPGF	T2031
LRRK2 (mouse)	CCRMGIKTSEGTPGF	T2031
LRRK2 (rat)	CCRMGIKTSEGTPGF	T2030

S2032

CRMGIKtsEGtPGFR

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced

Kinase, in vitro:

LRRK2 (human)

Treatment

FX2149
H2O2

LRRK2 (human)	CRMGIKtsEGtPGFR	S2032
LRRK2 (mouse)	CRMGIKTSEGTPGFR	S2032
LRRK2 (rat)	CRMGIKTSEGTPGFR	S2031

T2035

GIKtsEGtPGFRAPE

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced

Kinase, in vitro:

LRRK2 (human)

Treatment

H2O2

LRRK2 (human)	GIKtsEGtPGFRAPE	T2035
LRRK2 (mouse)	GIKTSEGTPGFRAPE	T2035
LRRK2 (rat)	GIKTSEGTPGFRAPE	T2034

S2166

HHNSRNAsIWLGCGH

LRRK2 (human)	HHNSRNAsIWLGCGH	S2166
LRRK2 (mouse)	NLNSKSATLWLGCGN	T2166
LRRK2 (rat)	NLNSKRATLWLGCGN	T2165

T2237

EDGKKRHtLEKMTDS

LRRK2 (human)	EDGKKRHtLEKMTDS	T2237
LRRK2 (mouse)	EEETKRHTLEKMTDS	T2237
LRRK2 (rat)	EDETRRHTLDKMTDS	T2236

S2257

CNSFSKQsKQKNFLL

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	CNSFSKQsKQKNFLL	S2257
LRRK2 (mouse)	CNSLAKQSKQSNFLL	S2257
LRRK2 (rat)	CNSFAKQSKQSHFLL	S2256

Y2449

RRLIRVIyNFCNSVR

LRRK2 (human)	RRLIRVIyNFCNSVR	Y2449
LRRK2 (mouse)	RRVIRTIHNFCDSVR	H2449
LRRK2 (rat)	RRVIRTIHNFCDSVR	H2448

T2460

NSVRVMMtAQLGSLK

LRRK2 (human)	NSVRVMMtAQLGSLK	T2460
LRRK2 (mouse)	DSVRAMATAQLGSLK	T2460
LRRK2 (rat)	DSVRAMATAQLGNLK	T2459

T2483

NRKNTEGtQKQKEIQ

Upstream

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	NRKNTEGtQKQKEIQ	T2483
LRRK2 (mouse)	KRKSTEGIQEQKEIQ	I2483
LRRK2 (rat)	KRKSTEGTQEQKEIQ	T2482

T2524

LAEKMRRtSVE____

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Kinase, in vitro:

LRRK2 (human)

LRRK2 (human)	LAEKMRRtSVE____	T2524
LRRK2 (mouse)	LADKMRKTSVE____	T2524
LRRK2 (rat)	LADKMRKTSVE____	T2523

Y2018

IIAKIADyGIAQyCC

Downstream

Effects on Modified Protein

phosphorylation

LRRK2 (human)	IIAKIADyGIAQyCC	Y2018
LRRK2 (mouse)	IIAKIADYGIAQYCC	Y2018
LRRK2 (rat)	IIAKIADYGIAQYCC	Y2017