Other Species / Isoforms
  CXCR4 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y14
SIYTSDNYSEEVGSG
0 1
CXCR4 (human) SIYTSDNyTEEMGsG Y12-p
CXCR4 iso2 (human) QIYTSDNYTEEMGSG Y16
CXCR4 (mouse) SIYTSDNYSEEVGSG Y14
CXCR4 (rat) EIYTSDNYSEEVGSG Y9
S20
NYSEEVGSGDYDSNK
0 1
CXCR4 (human) NyTEEMGsGDYDSMK S18-p
CXCR4 iso2 (human) NYTEEMGSGDYDSMK S22
CXCR4 (mouse) NYSEEVGSGDYDSNK S20
CXCR4 (rat) NYSEEVGSGDYDSNK S15
Y137
AFISLDRYLAIVHAT
1 0
CXCR4 (human) AFISLDRyLAIVHAT Y135-p
CXCR4 iso2 (human) AFISLDRYLAIVHAT Y139
CXCR4 (mouse) AFISLDRYLAIVHAT Y137
CXCR4 (rat) AFISLDRYLAIVHAT Y132
Y159
LLAEKAVYVGVWIPA
1 0
CXCR4 (human) LLAEKVVyVGVWIPA Y157-p
CXCR4 iso2 (human) LLAEKVVYVGVWIPA Y161
CXCR4 (mouse) LLAEKAVYVGVWIPA Y159
CXCR4 (rat) LLAEKAVYVGVWIPA Y154
K317
AFLGAKFKSSAQHAL
0 9
CXCR4 (human) AFLGAKFkTsAQHAL K310-ub
CXCR4 iso2 (human) AFLGAKFKTSAQHAL K314
CXCR4 (mouse) AFLGAKFKSSAQHAL K317
CXCR4 (rat) AFLGAKFKSSAQHAL K307
S319
LGAKFKSSAQHALNs
0 1
CXCR4 (human) LGAKFkTsAQHALts S312-p
CXCR4 iso2 (human) LGAKFKTSAQHALTS S316
CXCR4 (mouse) LGAKFKSSAQHALNs S319
CXCR4 (rat) LGAKFKSSAQHALNS S309
N325
SSAQHALNsMsRGss
0 4
CXCR4 (human) TsAQHALtsVsRGss T318-p
CXCR4 iso2 (human) TSAQHALTSVSRGSS T322
CXCR4 (mouse) SSAQHALNsMsRGss N325
CXCR4 (rat) SSAQHALNSMSRGSS N315
S326-p
SAQHALNsMsRGssL
Upstream
0 25
Treatment
  • LPS
CXCR4 (human) sAQHALtsVsRGssL S319-p
CXCR4 iso2 (human) SAQHALTSVSRGSSL S323
CXCR4 (mouse) SAQHALNsMsRGssL S326-p
CXCR4 (rat) SAQHALNSMSRGSSL S316
S328-p
QHALNsMsRGssLkI
Upstream
0 14
Treatment
  • LPS
CXCR4 (human) QHALtsVsRGssLkI S321-p
CXCR4 iso2 (human) QHALTSVSRGSSLKI S325
CXCR4 (mouse) QHALNsMsRGssLkI S328-p
CXCR4 (rat) QHALNSMSRGSSLKI S318
S331-p
LNsMsRGssLkILSK
Upstream
11 15
CXCR4 (human)
S324-p
Regulatory protein:
  • CXCR4 (human)
Treatment
  • CXCL12
  • EGF
  • NKH_477
  • phorbol_ester
  • staurosporine
CXCR4 (human) LtsVsRGssLkILsk S324-p
CXCR4 iso2 (human) LTSVSRGSSLKILSK S328
CXCR4 (mouse) LNsMsRGssLkILSK S331-p
CXCR4 (rat) LNSMSRGSSLKILSK S321
S332-p
NsMsRGssLkILSKG
Upstream
10 18
CXCR4 (human)
S325-p
Regulatory protein:
  • CXCR4 (human)
Treatment
  • CXCL12
  • EGF
  • NKH_477
  • phorbol_ester
  • staurosporine
CXCR4 (human) tsVsRGssLkILskG S325-p
CXCR4 iso2 (human) TSVSRGSSLKILSKG S329
CXCR4 (mouse) NsMsRGssLkILSKG S332-p
CXCR4 (rat) NSMSRGSSLKILSKG S322
K334-ub
MsRGssLkILSKGKR
1 6
CXCR4 (human) VsRGssLkILskGkr K327-ub
CXCR4 iso2 (human) VSRGSSLKILSKGKR K331
CXCR4 (mouse) MsRGssLkILSKGKR K334-ub
CXCR4 (rat) MSRGSSLKILSKGKR K324
S337
GssLkILSKGKRGGH
3 2
CXCR4 (human) GssLkILskGkrGGH S330-p
CXCR4 iso2 (human) GSSLKILSKGKRGGH S334
CXCR4 (mouse) GssLkILSKGKRGGH S337
CXCR4 (rat) GSSLKILSKGKRGGH S327
K338
ssLkILSKGKRGGHs
1 1
CXCR4 (human) ssLkILskGkrGGHs K331-ub
CXCR4 iso2 (human) SSLKILSKGKRGGHS K335
CXCR4 (mouse) ssLkILSKGKRGGHs K338
CXCR4 (rat) SSLKILSKGKRGGHS K328
K340
LkILSKGKRGGHssV
1 2
CXCR4 (human) LkILskGkrGGHssV K333-ub
CXCR4 iso2 (human) LKILSKGKRGGHSSV K337
CXCR4 (mouse) LkILSKGKRGGHssV K340
CXCR4 (rat) LKILSKGKRGGHSSV K330
R341
kILSKGKRGGHssVs
0 2
CXCR4 (human) kILskGkrGGHssVs R334-m1
CXCR4 iso2 (human) KILSKGKRGGHSSVS R338
CXCR4 (mouse) kILSKGKRGGHssVs R341
CXCR4 (rat) KILSKGKRGGHSSVS R331
S345-p
KGKRGGHssVsTESE
Upstream
1 1
Regulatory protein:
  • CXCR4 (human)
Treatment
  • CXCL12
  • EGF
  • NKH_477
  • phorbol_ester
  • staurosporine
CXCR4 (human) kGkrGGHssVstEsE S338-p
CXCR4 iso2 (human) KGKRGGHSSVSTESE S342
CXCR4 (mouse) KGKRGGHssVsTESE S345-p
CXCR4 (rat) KGKRGGHSSVSTESE S335
S346-p
GKRGGHssVsTESEs
Upstream
11 11
CXCR4 (human)
S339-p
CXCR4 (mouse)
S346-p
CXCR4 (rat)
S336-p
Kinase, in vitro:
  • Pim1 (human)
Regulatory protein:
  • CXCR4 (human)
Treatment
  • CXCL12
  • EGF
  • LPS
  • NKH_477
  • phorbol_ester
  • staurosporine
CXCR4 (human) GkrGGHssVstEsEs S339-p
CXCR4 iso2 (human) GKRGGHSSVSTESES S343
CXCR4 (mouse) GKRGGHssVsTESEs S346-p
CXCR4 (rat) GKRGGHSSVSTESES S336
S348-p
RGGHssVsTESEsss
1 2
CXCR4 (human) rGGHssVstEsEsss S341-p
CXCR4 iso2 (human) RGGHSSVSTESESSS S345
CXCR4 (mouse) RGGHssVsTESEsss S348-p
CXCR4 (rat) RGGHSSVSTESESSS S338
T349
GGHssVsTESEsssF
0 6
CXCR4 (human) GGHssVstEsEsssF T342-p
CXCR4 iso2 (human) GGHSSVSTESESSSF T346
CXCR4 (mouse) GGHssVsTESEsssF T349
CXCR4 (rat) GGHSSVSTESESSSF T339
S351
HssVsTESEsssFHS
0 3
CXCR4 (human) HssVstEsEsssFHs S344-p
CXCR4 iso2 (human) HSSVSTESESSSFHS S348
CXCR4 (mouse) HssVsTESEsssFHS S351
CXCR4 (rat) HSSVSTESESSSFHS S341
S353-p
sVsTESEsssFHSs_
Upstream
Downstream
1 3
Effects on Modified Protein
  • phosphorylation
  • receptor desensitization, inhibited
  • receptor internalization, induced
Putative in vivo kinases:
  • GRK2 (human)
  • GRK3 (human)
Regulatory protein:
  • CXCR4 (human)
Treatment
  • CXCL12
  • EGF
  • NKH_477
  • phorbol_ester
  • siRNA
  • staurosporine
CXCR4 (human) sVstEsEsssFHss_ S346-p
CXCR4 iso2 (human) SVSTESESSSFHSS_ S350
CXCR4 (mouse) sVsTESEsssFHSs_ S353-p
CXCR4 (rat) SVSTESESSSFHSS_ S343
S354-p
VsTESEsssFHSs__
Upstream
Downstream
1 3
Effects on Modified Protein
  • phosphorylation
  • receptor desensitization, inhibited
  • receptor internalization, induced
Putative in vivo kinases:
  • GRK2 (human)
  • GRK3 (human)
Regulatory protein:
  • CXCR4 (human)
Treatment
  • CXCL12
  • EGF
  • NKH_477
  • phorbol_ester
  • siRNA
  • staurosporine
CXCR4 (human) VstEsEsssFHss__ S347-p
CXCR4 iso2 (human) VSTESESSSFHSS__ S351
CXCR4 (mouse) VsTESEsssFHSs__ S354-p
CXCR4 (rat) VSTESESSSFHSS__ S344
S355-p
sTESEsssFHSs___
0 16
CXCR4 (human) stEsEsssFHss___ S348-p
CXCR4 iso2 (human) STESESSSFHSS___ S352
CXCR4 (mouse) sTESEsssFHSs___ S355-p
CXCR4 (rat) STESESSSFHSS___ S345
S358
SEsssFHSs______
0 6
CXCR4 (human) sEsssFHss______ S351-p
CXCR4 iso2 (human) SESSSFHSS______ S355
CXCR4 (mouse) SEsssFHSs______ S358
CXCR4 (rat) SESSSFHSS______ S348
S359-p
EsssFHSs_______
1 3
CXCR4 (human) EsssFHss_______ S352-p
CXCR4 iso2 (human) ESSSFHSS_______ S356
CXCR4 (mouse) EsssFHSs_______ S359-p
CXCR4 (rat) ESSSFHSS_______ S349