Other Species / Isoforms
  HIPK2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S16
ASHVQVFSPHTLQSS
0 1
HIPK2 (human) ASHVQVFSPHTLQSS S16
HIPK2 (mouse) ASHVQVFsPHTLQSS S16-p
HIPK2 (rat) ASHVQVFSPHTLQSS S16
K32-sm
FCSVKKLkIEPSSNW
Upstream
Downstream
3 1
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • transcription, induced
  • transcription, inhibited
Regulatory protein:
  • PIAS4 (human)
Treatment
  • adriamycin
  • SB203580
HIPK2 (human) FCSVKKLkIEPSSNW K32-sm
HIPK2 (mouse) FCSVKKLKVEPSSNW K32
HIPK2 (rat) FCSVKKLKVEPSSNW K32
K32-ub
FCSVKKLkIEPSSNW
Downstream
1 0
Effects on Modified Protein
  • protein degradation
HIPK2 (human) FCSVKKLkIEPSSNW K32-ub
HIPK2 (mouse) FCSVKKLKVEPSSNW K32
HIPK2 (rat) FCSVKKLKVEPSSNW K32
Y44-p
SNWDMTGyGsHSKVY
0 1
HIPK2 (human) SNWDMTGyGsHSKVY Y44-p
HIPK2 (mouse) SNWDMTGYGSHSKVY Y44
HIPK2 (rat) SNWDMTGYGSHSKVY Y44
S46-p
WDMTGyGsHSKVYSQ
0 1
HIPK2 (human) WDMTGyGsHSKVYSQ S46-p
HIPK2 (mouse) WDMTGYGSHSKVYSQ S46
HIPK2 (rat) WDMTGYGSHSKVYSQ S46
S118
PHNLMRRStVsLLDT
0 1
HIPK2 (human) PHNLMRRStVsLLDT S118
HIPK2 (mouse) PHNLMRRsTVSLLDT S118-p
HIPK2 (rat) PHNLMRRSTVSLLDT S118
T119-p
HNLMRRStVsLLDTY
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA2 (human)
Regulatory protein:
  • ATM (human)
Treatment
  • cycloheximide
  • ionizing_radiation
  • siRNA
HIPK2 (human) HNLMRRStVsLLDTY T119-p
HIPK2 (mouse) HNLMRRsTVSLLDTY T119
HIPK2 (rat) HNLMRRSTVSLLDTY T119
S121-p
LMRRStVsLLDTYQK
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA2 (human)
Regulatory protein:
  • ATM (human)
Treatment
  • cycloheximide
  • ionizing_radiation
  • siRNA
HIPK2 (human) LMRRStVsLLDTYQK S121-p
HIPK2 (mouse) LMRRsTVSLLDTYQK S121
HIPK2 (rat) LMRRSTVSLLDTYQK S121
S135
KCGLKRKSEEIENTS
0 1
HIPK2 (human) KCGLKRKSEEIENTS S135
HIPK2 (mouse) KCGLKRKsEEIENtS S135-p
HIPK2 (rat) KCGLKRKSEEIENTS S135
T141
KSEEIENTSSVQIIE
0 1
HIPK2 (human) KSEEIENTSSVQIIE T141
HIPK2 (mouse) KsEEIENtSSVQIIE T141-p
HIPK2 (rat) KSEEIENTSSVQIIE T141
T252
SILARLSTESADDyN
0 1
HIPK2 (human) SILARLSTESADDyN T252
HIPK2 (mouse) SILARLStESADDYN T252-p
HIPK2 (rat) SILARLSTESADDYN T252
Y258-p
STESADDyNFVRAyE
0 1
HIPK2 (human) STESADDyNFVRAyE Y258-p
HIPK2 (mouse) StESADDYNFVRAYE Y258
HIPK2 (rat) STESADDYNFVRAYE Y258
Y264-p
DyNFVRAyECFQHKN
0 1
HIPK2 (human) DyNFVRAyECFQHKN Y264-p
HIPK2 (mouse) DYNFVRAYECFQHKN Y264
HIPK2 (rat) DYNFVRAYECFQHKN Y264
T273
CFQHKNHTCLVFEML
0 1
HIPK2 (human) CFQHKNHTCLVFEML T273
HIPK2 (mouse) CFQHKNHtCLVFEML T273-p
HIPK2 (rat) CFQHKNHTCLVFEML T273
S336-p
NIMLVDPsRQPyRVK
0 1
HIPK2 (human) NIMLVDPsRQPyRVK S336-p
HIPK2 (mouse) NIMLVDPSRQPYRVK S336
HIPK2 (rat) NIMLVDPSRQPYRVK S336
Y340-p
VDPsRQPyRVKVIDF
0 1
HIPK2 (human) VDPsRQPyRVKVIDF Y340-p
HIPK2 (mouse) VDPSRQPYRVKVIDF Y340
HIPK2 (rat) VDPSRQPYRVKVIDF Y340
S359-p
HVSKAVCstyLQsRY
Upstream
Downstream
1 26
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • signaling pathway regulation
Regulatory protein:
  • ASK1 (human)
Treatment
  • osimertinib
  • rociletinib
  • tunicamycin
HIPK2 (human) HVSKAVCstyLQsRY S359-p
HIPK2 (mouse) HVSKAVCStyLQsRY S359
HIPK2 (rat) HVSKAVCSTyLQSRY S359
T360-p
VSKAVCstyLQsRYy
Upstream
Downstream
1 23
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, induced
  • signaling pathway regulation
Regulatory protein:
  • ASK1 (human)
Treatment
  • tunicamycin
HIPK2 (human) VSKAVCstyLQsRYy T360-p
HIPK2 (mouse) VSKAVCStyLQsRYY T360-p
HIPK2 (rat) VSKAVCSTyLQSRYY T360
Y361-p
SKAVCstyLQsRYyR
Upstream
Downstream
6 3396
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • cell cycle regulation
  • cell growth, inhibited
  • signaling pathway regulation
  • transcription, inhibited
Putative in vivo kinases:
  • HIPK2 (human)
  • Src (human)
  • TAK1 (human)
Regulatory protein:
  • IRF6 (human)
Treatment
  • high_cell_density
  • siRNA
  • U0126
HIPK2 (human) SKAVCstyLQsRYyR Y361-p
HIPK2 (mouse) SKAVCStyLQsRYYR Y361-p
HIPK2 (rat) SKAVCSTyLQSRYYR Y361-p
S364-p
VCstyLQsRYyRAPE
Upstream
Downstream
1 335
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell cycle regulation
  • cell growth, inhibited
  • transcription, inhibited
Putative in vivo kinases:
  • HIPK2 (human)
HIPK2 (human) VCstyLQsRYyRAPE S364-p
HIPK2 (mouse) VCStyLQsRYYRAPE S364-p
HIPK2 (rat) VCSTyLQSRYYRAPE S364
Y367-p
tyLQsRYyRAPEIIL
Upstream
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • transcription, induced
Putative in vivo kinases:
  • Abl (human)
HIPK2 (human) tyLQsRYyRAPEIIL Y367-p
HIPK2 (mouse) tyLQsRYYRAPEIIL Y367
HIPK2 (rat) TyLQSRYYRAPEIIL Y367
Y423-p
TQGLPAEyLLSAGTk
0 1
HIPK2 (human) TQGLPAEyLLSAGTk Y423-p
HIPK2 (mouse) TQGLPAEYLLSAGTk Y423
HIPK2 (rat) TQGLPAEYLLSAGTK Y423
K430-ub
yLLSAGTkTTRFFNR
0 4
HIPK2 (human) yLLSAGTkTTRFFNR K430-ub
HIPK2 (mouse) YLLSAGTkTTRFFNR K430-ub
HIPK2 (rat) YLLSAGTKTTRFFNR K430
S441-p
FFNRDTDsPyPLWRL
Downstream
1 1
Effects on Modified Protein
  • protein conformation
HIPK2 (human) FFNRDTDsPyPLWRL S441-p
HIPK2 (mouse) FFNRDTDsPYPLWRL S441-p
HIPK2 (rat) FFNRDTDSPYPLWRL S441
Y443-p
NRDTDsPyPLWRLKT
0 1
HIPK2 (human) NRDTDsPyPLWRLKT Y443-p
HIPK2 (mouse) NRDTDsPYPLWRLKT Y443
HIPK2 (rat) NRDTDSPYPLWRLKT Y443
T482
DMAQVNMTTDLEGSD
0 1
HIPK2 (human) DMAQVNMTTDLEGSD T482
HIPK2 (mouse) DMAQVNMtTDLEGSD T482-p
HIPK2 (rat) DMAQVNMTTDLEGSD T482
T517
IDADKRITPIETLNH
0 1
HIPK2 (human) IDADKRITPIETLNH T517
HIPK2 (mouse) IDADKRVtPIETLNH T517-p
HIPK2 (rat) IDADKRITPIETLNH T517
K552-ub
FQNMEICkRRVNMyD
Downstream
1 2
Effects on Modified Protein
  • protein degradation
HIPK2 (human) FQNMEICkRRVNMyD K552-ub
HIPK2 (mouse) FQNMEICKRRVNMYD K552
HIPK2 (rat) FQNMEICKRRVNMYD K552
Y558-p
CkRRVNMyDTVNQSk
0 1
HIPK2 (human) CkRRVNMyDTVNQSk Y558-p
HIPK2 (mouse) CKRRVNMYDTVNQSK Y558
HIPK2 (rat) CKRRVNMYDTVNQSK Y558
K565-ub
yDTVNQSktPFITHV
Downstream
1 0
Effects on Modified Protein
  • protein degradation
HIPK2 (human) yDTVNQSktPFITHV K565-ub
HIPK2 (mouse) YDTVNQSKtPFITHV K565
HIPK2 (rat) YDTVNQSKTPFITHV K565
T566-p
DTVNQSktPFITHVA
Upstream
Downstream
1 2
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • cell growth, inhibited
Treatment
  • adriamycin
  • UV
HIPK2 (human) DTVNQSktPFITHVA T566-p
HIPK2 (mouse) DTVNQSKtPFITHVA T566-p
HIPK2 (rat) DTVNQSKTPFITHVA T566
S634
MAAVAQRSMPLQTGT
0 1
HIPK2 (human) MAAVAQRSMPLQTGT S634
HIPK2 (mouse) MAAVAPRsMPLQTGT S634-p
HIPK2 (rat) MAAVAQRSMPLQTGT S634
S668-p
GFQGLQAsPSkHAGY
Upstream
1 2
Kinase, in vitro:
  • HIPK2 (human)
HIPK2 (human) GFQGLQAsPSkHAGY S668-p
HIPK2 (mouse) GFQGLQAsPSKHAGY S668-p
HIPK2 (rat) GFQGLQASPSKHAGY S668
K671-ub
GLQAsPSkHAGYSVR
Downstream
1 0
Effects on Modified Protein
  • protein degradation
HIPK2 (human) GLQAsPSkHAGYSVR K671-ub
HIPK2 (mouse) GLQAsPSKHAGYSVR K671
HIPK2 (rat) GLQASPSKHAGYSVR K671
T687
ENAVPIVTQAPGAQP
0 1
HIPK2 (human) ENAVPIVTQAPGAQP T687
HIPK2 (mouse) ENAVPIVtQAPGAQP T687-p
HIPK2 (rat) ENAVPIVTQAPGAQP T687
T796-p
HVMRQQPtSTTSSRk
0 1
HIPK2 (human) HVMRQQPtSTTSSRk T796-p
HIPK2 (mouse) HVMRQQPTSTTSSRK T796
HIPK2 (rat) HVMRQQPTSTTSSRK T795
K803-ub
tSTTSSRkSkQHQSS
Downstream
1 0
Effects on Modified Protein
  • protein degradation
HIPK2 (human) tSTTSSRkSkQHQSS K803-ub
HIPK2 (mouse) TSTTSSRKSKQHQSS K803
HIPK2 (rat) TSTTSSRKSKQHQSS K802
K805-ub
TTSSRkSkQHQSSVR
Downstream
1 0
Effects on Modified Protein
  • protein degradation
HIPK2 (human) TTSSRkSkQHQSSVR K805-ub
HIPK2 (mouse) TTSSRKSKQHQSSVR K805
HIPK2 (rat) TTSSRKSKQHQSSAR K804
S815
QSSVRNVSTCEVSSS
0 1
HIPK2 (human) QSSVRNVSTCEVSSS S815
HIPK2 (mouse) QSSVRNVsTCEVTSS S815-p
HIPK2 (rat) QSSARNVSTCEVTSS S814
S826-p
VSSSQAIssPQRSKR
0 1
HIPK2 (human) VSSSQAIssPQRSKR S826-p
HIPK2 (mouse) VTSSQAISsPQRSKR S826
HIPK2 (rat) VTSSQAISSPQRSKR S825
S827-p
SSSQAIssPQRSKRV
Upstream
2 8
Kinase, in vitro:
  • HIPK2 (human)
HIPK2 (human) SSSQAIssPQRSKRV S827-p
HIPK2 (mouse) TSSQAISsPQRSKRV S827-p
HIPK2 (rat) TSSQAISSPQRSKRV S826
T838-p
SKRVKENtPPRCAMV
Upstream
2 2
Kinase, in vitro:
  • HIPK2 (human)
HIPK2 (human) SKRVKENtPPRCAMV T838-p
HIPK2 (mouse) SKRVKENTPPRCAMV T838
HIPK2 (rat) SKRVKENTPPRCAMV T837
S847
PRCAMVHSsPACSTS
0 1
HIPK2 (human) PRCAMVHSsPACSTS S847
HIPK2 (mouse) PRCAMVHsSPACSTS S847-p
HIPK2 (rat) PRCAMVHSSPACSTS S846
S848-p
RCAMVHSsPACSTSV
Upstream
1 0
Kinase, in vitro:
  • HIPK2 (human)
HIPK2 (human) RCAMVHSsPACSTSV S848-p
HIPK2 (mouse) RCAMVHsSPACSTSV S848
HIPK2 (rat) RCAMVHSSPACSTSL S847
T880-p
QTIVIPDtPsPTVSV
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
Kinase, in vitro:
  • HIPK2 (human)
Putative in vivo kinases:
  • HIPK2 (human)
Treatment
  • adriamycin
HIPK2 (human) QTIVIPDtPsPTVSV T880-p
HIPK2 (mouse) QTIVIPDTPSPTVSV T880
HIPK2 (rat) QTIVIPDTPSPTVSV T879
S882-p
IVIPDtPsPTVSVIT
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein conformation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
Kinase, in vitro:
  • HIPK2 (human)
Putative in vivo kinases:
  • HIPK2 (human)
Treatment
  • adriamycin
HIPK2 (human) IVIPDtPsPTVSVIT S882-p
HIPK2 (mouse) IVIPDTPSPTVSVIT S882
HIPK2 (rat) IVIPDTPSPTVSVIT S881
S924-p
SCVTVHDsPYSDSSS
Upstream
1 1
Kinase, in vitro:
  • HIPK2 (human)
HIPK2 (human) SCVTVHDsPYSDSSS S924-p
HIPK2 (mouse) SCVTVHDsPYSDSSS S924-p
HIPK2 (rat) SCVTVHDSPYSDSSS S923
S934-p
SDSSSNTsPYSVQQR
Upstream
1 3
Kinase, in vitro:
  • HIPK2 (human)
HIPK2 (human) SDSSSNTsPYSVQQR S934-p
HIPK2 (mouse) SDSSSNTsPYSVQQR S934-p
HIPK2 (rat) SDSSSNTSPYSVQQR S933
K953-sm
NANAFDTkGSLENHC
0 1
HIPK2 (human) NANAFDTkGSLENHC K953-sm
HIPK2 (mouse) GTNTLDTKGGLENHC K953
HIPK2 (rat) GTNTLDTKGGLENHC K952
N990
CDSLVPVNTSHHSSS
0 1
HIPK2 (human) CDSLVPVNTSHHSSS N990
HIPK2 (mouse) DSLGPAIsAsHHSSS S991-p
HIPK2 (rat) DSLGPAISTGHHSSS S990
S992
SLVPVNTSHHSSSYK
0 1
HIPK2 (human) SLVPVNTSHHSSSYK S992
HIPK2 (mouse) LGPAIsAsHHSSSFK S993-p
HIPK2 (rat) LGPAISTGHHSSSFK G992
S1008
KSSSNVTSTSGHSSG
0 1
HIPK2 (human) KSSSNVTSTSGHSSG S1008
HIPK2 (mouse) KSSSTVTsTSGHSSG S1009-gl
HIPK2 (rat) KSSSTVTSTSGHSSG S1008
S1041
QQQPLNLSQAQQHIT
0 1
HIPK2 (human) QQQPLNLSQAQQHIT S1041
HIPK2 (mouse) QQQPLNLsQAQQHMA S1042-p
HIPK2 (rat) QQQPLNLSQAQQHMA S1041
T1114-p
APAALGStGTVAHLV
Upstream
Downstream
1 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Kinase, in vitro:
  • AMPKA1 (human)
Putative in vivo kinases:
  • AMPKA2 (human)
Regulatory protein:
  • ATM (human)
Treatment
  • cycloheximide
  • ionizing_radiation
  • siRNA
HIPK2 (human) APAALGStGTVAHLV T1114-p
HIPK2 (mouse) APTALGSTGTVAHLV T1112
HIPK2 (rat) APTALGSTSTVAHLV T1111
Y1136-p
HTVQHTAyPASIVHQ
0 1
HIPK2 (human) HTVQHTAyPASIVHQ Y1136-p
HIPK2 (mouse) HTVQHTAYPASIVHQ Y1134
HIPK2 (rat) HTVQHTAYPASIVHQ Y1133
R1151-m1
VPVSMGPrVLPSPTI
0 1
HIPK2 (human) VPVSMGPrVLPSPTI R1151-m1
HIPK2 (mouse) VPVSMGPRVLPsPTI R1149
HIPK2 (rat) VPVSMGPRVLPSPTI R1148
S1155
MGPrVLPSPTIHPSQ
0 1
HIPK2 (human) MGPrVLPSPTIHPSQ S1155
HIPK2 (mouse) MGPRVLPsPTIHPSQ S1153-p
HIPK2 (rat) MGPRVLPSPTIHPSQ S1152
S1188-p
VYTGYPLsPAkVNQY
0 2
HIPK2 (human) VYTGYPLsPAkVNQY S1188-p
HIPK2 (mouse) VYTGYPLsPAKVNQY S1186-p
HIPK2 (rat) VYTGYPLSPAKVNQY S1185
K1191-sm
GYPLsPAkVNQYPyI
Downstream
1 0
Effects on Modified Protein
  • intracellular localization
HIPK2 (human) GYPLsPAkVNQYPyI K1191-sm
HIPK2 (mouse) GYPLsPAKVNQYPYI K1189
HIPK2 (rat) GYPLSPAKVNQYPYI K1188
K1191-ub
GYPLsPAkVNQYPyI
Downstream
2 0
Effects on Modified Protein
  • protein degradation
  • ubiquitination
HIPK2 (human) GYPLsPAkVNQYPyI K1191-ub
HIPK2 (mouse) GYPLsPAKVNQYPYI K1189
HIPK2 (rat) GYPLSPAKVNQYPYI K1188
Y1197-p
AkVNQYPyI______
0 1
HIPK2 (human) AkVNQYPyI______ Y1197-p
HIPK2 (mouse) AKVNQYPYI______ Y1195
HIPK2 (rat) AKVNQYPYI______ Y1194