K30-ub
|
RPRYFLLkSDGsFIG
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
RPRYFLLkSDGsFIG
|
K30-ub
|
Akt2 (mouse)
|
RPRYFLLKSDGsFIG
|
K30
|
Akt2 (rat)
|
RPRYFLLKSDGSFIG
|
K30
|
|
S34-p
|
FLLkSDGsFIGykER
|
|
|
0
|
8
|
|
|
Akt2 (human)
|
FLLkSDGsFIGykER
|
S34-p
|
Akt2 (mouse)
|
FLLKSDGsFIGYKER
|
S34-p
|
Akt2 (rat)
|
FLLKSDGSFIGYKER
|
S34
|
|
Y38-p
|
SDGsFIGykERPEAP
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
SDGsFIGykERPEAP
|
Y38-p
|
Akt2 (mouse)
|
SDGsFIGYKERPEAP
|
Y38
|
Akt2 (rat)
|
SDGSFIGYKERPEAP
|
Y38
|
|
K39-ub
|
DGsFIGykERPEAPD
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
DGsFIGykERPEAPD
|
K39-ub
|
Akt2 (mouse)
|
DGsFIGYKERPEAPD
|
K39
|
Akt2 (rat)
|
DGSFIGYKERPEAPD
|
K39
|
|
T81-p
|
VIRCLQWtTVIERTF
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
VIRCLQWtTVIERTF
|
T81-p
|
Akt2 (mouse)
|
VIRCLQWTTVIERTF
|
T81
|
Akt2 (rat)
|
VIRCLQWTTVIERTF
|
T81
|
|
K111-ub
|
QMVANSLkQRAPGED
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
QMVANSLkQRAPGED
|
K111-ub
|
Akt2 (mouse)
|
QMVANSLKQRGPGED
|
K111
|
Akt2 (rat)
|
QMVANSLKQRGPGED
|
K111
|
|
Y122-p
|
PGEDPMDyKCGsPsD
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
PGEDPMDyKCGsPsD
|
Y122-p
|
Akt2 (mouse)
|
PGEDAMDYKCGsPSD
|
Y122
|
Akt2 (rat)
|
PGEDAMDYKCGSPSD
|
Y122
|
|
S126-p
|
PMDyKCGsPsDSsTT
|
Upstream
|
|
1
|
18
|
|
|
|
Akt2 (human)
|
PMDyKCGsPsDSsTT
|
S126-p
|
Akt2 (mouse)
|
AMDYKCGsPSDsSTS
|
S126-p
|
Akt2 (rat)
|
AMDYKCGSPSDSSTS
|
S126
|
|
S128-p
|
DyKCGsPsDSsTTEE
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
DyKCGsPsDSsTTEE
|
S128-p
|
Akt2 (mouse)
|
DYKCGsPSDsSTSEM
|
S128
|
Akt2 (rat)
|
DYKCGSPSDSSTSEM
|
S128
|
|
S130
|
KCGsPsDSsTTEEME
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
KCGsPsDSsTTEEME
|
S130
|
Akt2 (mouse)
|
KCGsPSDsSTSEMME
|
S130-p
|
Akt2 (rat)
|
KCGSPSDSSTSEMME
|
S130
|
|
S131-p
|
CGsPsDSsTTEEMEV
|
Upstream
|
|
1
|
0
|
|
|
Kinase, in vitro:
|
Treatment
|
|
Akt2 (human)
|
CGsPsDSsTTEEMEV
|
S131-p
|
Akt2 (mouse)
|
CGsPSDsSTSEMMEV
|
S131
|
Akt2 (rat)
|
CGSPSDSSTSEMMEV
|
S131
|
|
S141-p
|
EEMEVAVskARAkVT
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
EEMEVAVskARAkVT
|
S141-p
|
Akt2 (mouse)
|
EMMEVAVNKARAKVT
|
N141
|
Akt2 (rat)
|
EMMEVAVSKARAKVT
|
S141
|
|
K142-ub
|
EMEVAVskARAkVTM
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
EMEVAVskARAkVTM
|
K142-ub
|
Akt2 (mouse)
|
MMEVAVNKARAKVTM
|
K142
|
Akt2 (rat)
|
MMEVAVSKARAKVTM
|
K142
|
|
K146-ub
|
AVskARAkVTMNDFD
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
AVskARAkVTMNDFD
|
K146-ub
|
Akt2 (mouse)
|
AVNKARAKVTMNDFD
|
K146
|
Akt2 (rat)
|
AVSKARAKVTMNDFD
|
K146
|
|
K156-ub
|
MNDFDYLkLLGKGTF
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
MNDFDYLkLLGKGTF
|
K156-ub
|
Akt2 (mouse)
|
MNDFDYLKLLGKGTF
|
K156
|
Akt2 (rat)
|
MNDFDYLKLLGKGTF
|
K156
|
|
Y177-p
|
REKATGRyyAMKILR
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
REKATGRyyAMKILR
|
Y177-p
|
Akt2 (mouse)
|
REKATGRYYAMKILR
|
Y177
|
Akt2 (rat)
|
REKATGRYYAMKILR
|
Y177
|
|
Y178-p
|
EKATGRyyAMKILRK
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
EKATGRyyAMKILRK
|
Y178-p
|
Akt2 (mouse)
|
EKATGRYYAMKILRK
|
Y178
|
Akt2 (rat)
|
EKATGRYYAMKILRK
|
Y178
|
|
K191-ub
|
RKEVIIAkDEVAHTV
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
RKEVIIAkDEVAHTV
|
K191-ub
|
Akt2 (mouse)
|
RKEVIIAKDEVAHTV
|
K191
|
Akt2 (rat)
|
RKEVIIAKDEVAHTV
|
K191
|
|
S242-p
|
GELFFHLsRERVFTE
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
GELFFHLsRERVFTE
|
S242-p
|
Akt2 (mouse)
|
GELFFHLSRERVFTE
|
S242
|
Akt2 (rat)
|
GDLFFHLSRERVFTE
|
S242
|
|
Y255
|
TEERARFYGAEIVSA
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
TEERARFYGAEIVSA
|
Y255
|
Akt2 (mouse)
|
TEDRARFyGAEIVsA
|
Y255-p
|
Akt2 (rat)
|
TEDRARFYGAEIVSA
|
Y255
|
|
S261
|
FYGAEIVSALEYLHS
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
FYGAEIVSALEYLHS
|
S261
|
Akt2 (mouse)
|
FyGAEIVsALEyLHS
|
S261-p
|
Akt2 (rat)
|
FYGAEIVSALEYLHS
|
S261
|
|
Y265
|
EIVSALEYLHSRDVV
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
EIVSALEYLHSRDVV
|
Y265
|
Akt2 (mouse)
|
EIVsALEyLHSRDVV
|
Y265-p
|
Akt2 (rat)
|
EIVSALEYLHSTDVV
|
Y265
|
|
K277-ub
|
DVVYRDIkLENLMLD
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
DVVYRDIkLENLMLD
|
K277-ub
|
Akt2 (mouse)
|
DVVYRDIKLENLMLD
|
K277
|
Akt2 (rat)
|
DVVYRDIKLENLMLD
|
K277
|
|
K298-ub
|
ITDFGLCkEGIsDGA
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
ITDFGLCkEGIsDGA
|
K298-ub
|
Akt2 (mouse)
|
ITDFGLCKEGIsDGA
|
K298
|
Akt2 (rat)
|
ITDFGLSKEGISDGA
|
K298
|
|
S302-p
|
GLCkEGIsDGAtMKt
|
|
|
0
|
5
|
|
|
Akt2 (human)
|
GLCkEGIsDGAtMKt
|
S302-p
|
Akt2 (mouse)
|
GLCKEGIsDGAtMKt
|
S302-p
|
Akt2 (rat)
|
GLSKEGISDGATMKt
|
S302
|
|
T306-p
|
EGIsDGAtMKtFCGt
|
Upstream
|
|
0
|
8
|
|
|
|
Akt2 (human)
|
EGIsDGAtMKtFCGt
|
T306-p
|
Akt2 (mouse)
|
EGIsDGAtMKtFCGt
|
T306-p
|
Akt2 (rat)
|
EGISDGATMKtFCGT
|
T306
|
|
T309-p
|
sDGAtMKtFCGtPEy
|
Upstream
|
Downstream
|
16
|
26
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- intracellular localization
|
|
Kinase, in vitro:
|
Regulatory protein:
- APOE (human)
- Notch 1 (human)
|
Treatment
- Akt-I-1
- Akt-I-1,2
- arachidonic_acid
- EGF
- fMLP
- IGF-1
- insulin
- NGF
- phorbol_ester
|
|
Akt2 (human)
|
sDGAtMKtFCGtPEy
|
T309-p
|
Akt2 (mouse)
|
sDGAtMKtFCGtPEY
|
T309-p
|
Akt2 (rat)
|
SDGATMKtFCGTPEY
|
T309-p
|
|
T313-p
|
tMKtFCGtPEyLAPE
|
Upstream
|
|
0
|
5
|
|
|
|
Akt2 (human)
|
tMKtFCGtPEyLAPE
|
T313-p
|
Akt2 (mouse)
|
tMKtFCGtPEYLAPE
|
T313-p
|
Akt2 (rat)
|
TMKtFCGTPEYLAPE
|
T313
|
|
Y316-p
|
tFCGtPEyLAPEVLE
|
|
|
0
|
12
|
|
|
Akt2 (human)
|
tFCGtPEyLAPEVLE
|
Y316-p
|
Akt2 (mouse)
|
tFCGtPEYLAPEVLE
|
Y316
|
Akt2 (rat)
|
tFCGTPEYLAPEVLE
|
Y316
|
|
Y327-p
|
EVLEDNDyGRAVDWW
|
|
|
0
|
27
|
|
|
Akt2 (human)
|
EVLEDNDyGRAVDWW
|
Y327-p
|
Akt2 (mouse)
|
EVLEDNDyGRAVDWW
|
Y327-p
|
Akt2 (rat)
|
EVLEDNDYGRAVDWW
|
Y327
|
|
K378-ac
|
RTLSPEAksLLAGLL
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
RTLSPEAksLLAGLL
|
K378-ac
|
Akt2 (mouse)
|
RTLGPEAKSLLAGLL
|
K378
|
Akt2 (rat)
|
RTLGPEAKSLLAGLL
|
K378
|
|
K378-ub
|
RTLSPEAksLLAGLL
|
Upstream
|
|
0
|
2
|
|
|
|
Akt2 (human)
|
RTLSPEAksLLAGLL
|
K378-ub
|
Akt2 (mouse)
|
RTLGPEAKSLLAGLL
|
K378
|
Akt2 (rat)
|
RTLGPEAKSLLAGLL
|
K378
|
|
S379-p
|
TLSPEAksLLAGLLK
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
TLSPEAksLLAGLLK
|
S379-p
|
Akt2 (mouse)
|
TLGPEAKSLLAGLLK
|
S379
|
Akt2 (rat)
|
TLGPEAKSLLAGLLK
|
S379
|
|
K401-ub
|
GGGPSDAkEVMEHRF
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
GGGPSDAkEVMEHRF
|
K401-ub
|
Akt2 (mouse)
|
GGGPSDAKEVMEHRF
|
K401
|
Akt2 (rat)
|
GGGPSDAKEVMEHRF
|
K401
|
|
K427-ub
|
KKLLPPFkPQVTSEV
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
KKLLPPFkPQVTSEV
|
K427-ub
|
Akt2 (mouse)
|
KKLLPPFKPQVTSEV
|
K427
|
Akt2 (rat)
|
KKLLPPFKPQVTSEV
|
K427
|
|
Y438-p
|
TSEVDTRyFDDEFTA
|
|
|
0
|
4
|
|
|
Akt2 (human)
|
TSEVDTRyFDDEFTA
|
Y438-p
|
Akt2 (mouse)
|
TSEVDTRYFDDEFTA
|
Y438
|
Akt2 (rat)
|
TSEVDTRYFDDEFTA
|
Y438
|
|
S447-p
|
DDEFTAQsItItPPD
|
|
|
0
|
3
|
|
|
Akt2 (human)
|
DDEFTAQsItItPPD
|
S447-p
|
Akt2 (mouse)
|
DDEFTAQsITItPPD
|
S447-p
|
Akt2 (rat)
|
DDEFTAQSITItPPD
|
S447
|
|
T449-p
|
EFTAQsItItPPDRy
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
EFTAQsItItPPDRy
|
T449-p
|
Akt2 (mouse)
|
EFTAQsITItPPDRy
|
T449
|
Akt2 (rat)
|
EFTAQSITItPPDRY
|
T449
|
|
T451-p
|
TAQsItItPPDRyDs
|
Upstream
|
|
2
|
30
|
|
|
|
Treatment
- cinnamaldehyde
- curcumin
- IGF-1
- insulin
- virus infection
|
|
Akt2 (human)
|
TAQsItItPPDRyDs
|
T451-p
|
Akt2 (mouse)
|
TAQsITItPPDRyDs
|
T451-p
|
Akt2 (rat)
|
TAQSITItPPDRYDS
|
T451-p
|
|
Y456-p
|
tItPPDRyDsLGLLE
|
|
|
0
|
2
|
|
|
Akt2 (human)
|
tItPPDRyDsLGLLE
|
Y456-p
|
Akt2 (mouse)
|
TItPPDRyDsLDPLE
|
Y456-p
|
Akt2 (rat)
|
TItPPDRYDSLGsLE
|
Y456
|
|
S458-p
|
tPPDRyDsLGLLELD
|
|
|
0
|
5
|
|
|
Akt2 (human)
|
tPPDRyDsLGLLELD
|
S458-p
|
Akt2 (mouse)
|
tPPDRyDsLDPLELD
|
S458-p
|
Akt2 (rat)
|
tPPDRYDSLGsLELD
|
S458
|
|
L461
|
DRyDsLGLLELDQRT
|
|
|
0
|
1
|
|
|
Akt2 (human)
|
DRyDsLGLLELDQRT
|
L461
|
Akt2 (mouse)
|
DRyDsLDPLELDQRT
|
P461
|
Akt2 (rat)
|
DRYDSLGsLELDQRT
|
S461-p
|
|
S474-p
|
RTHFPQFsysAsIRE
|
Upstream
|
Downstream
|
36
|
64
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- intracellular localization
|
Effects on Biological Processes:
- signaling pathway regulation
|
|
Putative upstream phosphatases:
|
Regulatory protein:
- APOE (human)
- Fyn (human)
- IL24 (human)
- Notch 1 (human)
- p70S6K (human)
- PHLPP (human)
- PHLPP2 (human)
- SH2-B-beta (human)
- Srcasm (human)
- USP49 (human)
|
Treatment
- Akt-I-1
- Akt-I-1,2
- arachidonic_acid
- cAMP_analog
- cinnamaldehyde
- curcumin
- EGF
- FGF1
- fMLP
- gefitinib
- heat_shock
- hypertonic_buffer
- IGF-1
- imatinib
- insulin
- ischemia
- LH
- LY294002
- NGF
- okadaic_acid
- PD98059
- PDGF
- phorbol_ester
- PTP1B_inhibitor
- rapamycin
- serum
- siRNA
- Su11274
- TGF-alpha
- TNF
- U0126
- UV
|
|
Akt2 (human)
|
RTHFPQFsysAsIRE
|
S474-p
|
Akt2 (mouse)
|
RTHFPQFsysAsIRE
|
S474-p
|
Akt2 (rat)
|
RTHFPQFsYSASIRE
|
S474-p
|
|
Y475-p
|
THFPQFsysAsIRE_
|
|
|
1
|
22
|
|
|
Akt2 (human)
|
THFPQFsysAsIRE_
|
Y475-p
|
Akt2 (mouse)
|
THFPQFsysAsIRE_
|
Y475-p
|
Akt2 (rat)
|
THFPQFsYSASIRE_
|
Y475
|
|
S476-p
|
HFPQFsysAsIRE__
|
|
|
0
|
10
|
|
|
Akt2 (human)
|
HFPQFsysAsIRE__
|
S476-p
|
Akt2 (mouse)
|
HFPQFsysAsIRE__
|
S476-p
|
Akt2 (rat)
|
HFPQFsYSASIRE__
|
S476
|
|
S478-p
|
PQFsysAsIRE____
|
Upstream
|
|
0
|
53
|
|
|
|
Akt2 (human)
|
PQFsysAsIRE____
|
S478-p
|
Akt2 (mouse)
|
PQFsysAsIRE____
|
S478-p
|
Akt2 (rat)
|
PQFsYSASIRE____
|
S478
|
|