Other Species / Isoforms
  TAK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K63-ub
RAKDVAIkQIESESE
1 1
TAK1 (human) RAKDVAIkQIESESE K63-ub
TAK1 iso2 (human) RAKDVAIKQIESESE K63
TAK1 (mouse) RAKDVAIKQIESESE K63
TAK1 iso3 (mouse) RAKDVAIKQIESESE K63
TAK1 (rat) RAKDVAIKQIESESE K63
K72-ub
IESESERkAFIVELR
Upstream
Downstream
1 1
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • transcription, inhibited
Treatment
  • MG132
  • TNF
TAK1 (human) IESESERkAFIVELR K72-ub
TAK1 iso2 (human) IESESERKAFIVELR K72
TAK1 (mouse) IESESERKAFIVELR K72
TAK1 iso3 (mouse) IESESERKAFIVELR K72
TAK1 (rat) IESESERKAFIVELR K72
K158-ub
ALIHRDLkPPNLLLV
Upstream
Downstream
2 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, induced
Treatment
  • IL-1b
  • TNF
TAK1 (human) ALIHRDLkPPNLLLV K158-ub
TAK1 iso2 (human) ALIHRDLKPPNLLLV K158
TAK1 (mouse) ALIHRDLKPPNLLLV K158
TAK1 iso3 (mouse) ALIHRDLKPPNLLLV K158
TAK1 (rat) ALIHRDLKPPNLLLV K158
T178-p
LKICDFGtACDIQtH
Upstream
Downstream
2 0
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative in vivo kinases:
  • TAK1 (human)
Treatment
  • IL-1b
TAK1 (human) LKICDFGtACDIQtH T178-p
TAK1 iso2 (human) LKICDFGTACDIQTH T178
TAK1 (mouse) LKICDFGTACDIQtH T178
TAK1 iso3 (mouse) LKICDFGTACDIQtH T178
TAK1 (rat) LKICDFGTACDIQTH T178
T184-p
GtACDIQtHMtNNKG
Upstream
Downstream
16 0
TAK1 (human)
T184-p
TAK1 (mouse)
T184-p
TAK1 (rat)
T184-p
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • TAK1 (human)
Putative in vivo kinases:
  • TAK1 (human)
Regulatory protein:
  • AlphaK3 (human)
  • ATM (human)
  • Bcl-10 (human)
  • CLASP1 (human)
  • DUSP14 (human)
  • IRF6 (human)
  • RALBP1 (human)
  • TAB1 (human)
  • TAB2 (human)
  • TIFA (human)
  • TRAF6 (human)
  • UBE2N (human)
Treatment
  • (5Z)-7-oxozeaenol
  • BAPTA-AM
  • carrageenan
  • high_cell_density
  • IL-1b
  • ionizing_radiation
  • ionomycin
  • monosodium urate
  • phorbol_ester
  • TAK1_inhibitor
  • TNF
TAK1 (human) GtACDIQtHMtNNKG T184-p
TAK1 iso2 (human) GTACDIQTHMTNNKG T184
TAK1 (mouse) GTACDIQtHMtNNKG T184-p
TAK1 iso3 (mouse) GTACDIQtHMtNNKG T184-p
TAK1 (rat) GTACDIQTHMtNNKG T184
T187-p
CDIQtHMtNNKGsAA
Upstream
Downstream
25 1
TAK1 (human)
T187-p
TAK1 (mouse)
T187-p
TAK1 (rat)
T187-p
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, altered
Kinase, in vitro:
  • TAK1 (human)
Phosphatases, in vitro:
  • PPP2CA (human)
Putative in vivo kinases:
  • TAK1 (human)
  • TAK1 (mouse)
Putative upstream phosphatases:
  • PPP2CA (mouse)
Regulatory protein:
  • AlphaK3 (human)
  • ATM (human)
  • Bcl-10 (human)
  • CLASP1 (human)
  • DUSP14 (human)
  • IRF6 (human)
  • P38A (human)
  • PPP2CA (mouse)
  • RALBP1 (human)
  • TAB1 (human)
  • TAB2 (human)
  • TIFA (human)
  • TRAF6 (human)
  • UBE2N (human)
  • yopJ (bacteria)
Treatment
  • (5Z)-7-oxozeaenol
  • anisomycin
  • bacterial infection
  • BAPTA-AM
  • calyculin_A
  • carrageenan
  • ciclosporin
  • EGF
  • ethanol
  • gomisin_A
  • gomisin_N
  • high_cell_density
  • hypertonic_buffer
  • IL-1a
  • IL-1b
  • ionizing_radiation
  • ionomycin
  • monosodium urate
  • okadaic_acid
  • phorbol_ester
  • SB203580
  • siRNA
  • TAK1_inhibitor
  • tautomycin
  • TGF-beta
  • TNF
TAK1 (human) CDIQtHMtNNKGsAA T187-p
TAK1 iso2 (human) CDIQTHMTNNKGSAA T187
TAK1 (mouse) CDIQtHMtNNKGsAA T187-p
TAK1 iso3 (mouse) CDIQtHMtNNKGSAA T187-p
TAK1 (rat) CDIQTHMtNNKGSAA T187-p
S192-p
HMtNNKGsAAWMAPE
Upstream
Downstream
5 1
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative in vivo kinases:
  • TAK1 (human)
Regulatory protein:
  • Bcl-10 (human)
Treatment
  • carrageenan
TAK1 (human) HMtNNKGsAAWMAPE S192-p
TAK1 iso2 (human) HMTNNKGSAAWMAPE S192
TAK1 (mouse) HMtNNKGsAAWMAPE S192-p
TAK1 iso3 (mouse) HMtNNKGSAAWMAPE S192
TAK1 (rat) HMtNNKGSAAWMAPE S192
Y206-p
EVFEGSNySEkCDVF
Upstream
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
  • ubiquitination
Putative upstream phosphatases:
  • SHP-1 (human)
TAK1 (human) EVFEGSNySEkCDVF Y206-p
TAK1 iso2 (human) EVFEGSNYSEKCDVF Y206
TAK1 (mouse) EVFEGSNYSEKCDVF Y206
TAK1 iso3 (mouse) EVFEGSNYSEKCDVF Y206
TAK1 (rat) EVFEGSNYSEKCDVF Y206
K209-ub
EGSNySEkCDVFSWG
Upstream
Downstream
2 0
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
  • protein stabilization
Effects on Biological Processes:
  • apoptosis, induced
  • signaling pathway regulation
Regulatory protein:
  • IL17RD (human)
Treatment
  • IL-1a
TAK1 (human) EGSNySEkCDVFSWG K209-ub
TAK1 iso2 (human) EGSNYSEKCDVFSWG K209
TAK1 (mouse) EGSNYSEKCDVFSWG K209
TAK1 iso3 (mouse) EGSNYSEKCDVFSWG K209
TAK1 (rat) EGSNYSEKCDVFSWG K209
K269-ub
LMTRCWSkDPSQRPS
0 2
TAK1 (human) LMTRCWSkDPSQRPS K269-ub
TAK1 iso2 (human) LMTRCWSKDPSQRPS K269
TAK1 (mouse) LMTRCWSKDPSQRPS K269
TAK1 iso3 (mouse) LMTRCWSKDPSQRPS K269
TAK1 (rat) LMTRCWSKDPSQRPS K269
T333-p
NTSNKSDtNMEQVPA
0 1
TAK1 (human) NTSNKSDtNMEQVPA T333-p
TAK1 iso2 (human) NTSNKSDTNMEQVPA T333
TAK1 (mouse) NTSNKSDTNMEQVPA T333
TAK1 iso3 (mouse) NTSNKSDTNMEQVPA T333
TAK1 (rat) NTSNKSDTNMEQVPA T333
T344-p
QVPATNDtIkRLESk
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • calyculin_A
TAK1 (human) QVPATNDtIkRLESk T344-p
TAK1 iso2 (human) QVPATNDTIKRLESK T344
TAK1 (mouse) QVPATNDTIKRLESK T344
TAK1 iso3 (mouse) QVPATNDTIKRLESK T344
TAK1 (rat) QVPATNDTIKRLESK T344
K346-ub
PATNDtIkRLESkLL
0 1
TAK1 (human) PATNDtIkRLESkLL K346-ub
TAK1 iso2 (human) PATNDTIKRLESKLL K346
TAK1 (mouse) PATNDTIKRLESKLL K346
TAK1 iso3 (mouse) PATNDTIKRLESKLL K346
TAK1 (rat) PATNDTIKRLESKLL K346
K351-ub
tIkRLESkLLkNQAK
0 2
TAK1 (human) tIkRLESkLLkNQAK K351-ub
TAK1 iso2 (human) TIKRLESKLLKNQAK K351
TAK1 (mouse) TIKRLESKLLKNQAK K351
TAK1 iso3 (mouse) TIKRLESKLLKNQAK K351
TAK1 (rat) TIKRLESKLLKNQAK K351
K354-ub
RLESkLLkNQAKQQs
0 1
TAK1 (human) RLESkLLkNQAKQQs K354-ub
TAK1 iso2 (human) RLESKLLKNQAKQQS K354
TAK1 (mouse) RLESKLLKNQAKQQs K354
TAK1 iso3 (mouse) RLESKLLKNQAKQQS K354
TAK1 (rat) RLESKLLKNQAKQQS K354
S361-p
kNQAKQQsESGRLsL
0 1
TAK1 (human) kNQAKQQsESGRLsL S361-p
TAK1 iso2 (human) KNQAKQQSESGRLSL S361
TAK1 (mouse) KNQAKQQsESGRLsL S361-p
TAK1 iso3 (mouse) KNQAKQQSESGRLSL S361
TAK1 (rat) KNQAKQQSDSGRLSL S361
S367-p
QsESGRLsLGAsRGS
0 6
TAK1 (human) QsESGRLsLGAsRGS S367-p
TAK1 iso2 (human) QSESGRLSLGASRGS S367
TAK1 (mouse) QsESGRLsLGAsRGS S367-p
TAK1 iso3 (mouse) QSESGRLSLGASRGS S367
TAK1 (rat) QSDSGRLSLGASRGS S367
S371-p
GRLsLGAsRGSsVES
0 6
TAK1 (human) GRLsLGAsRGSsVES S371-p
TAK1 iso2 (human) GRLSLGASRGSSVES S371
TAK1 (mouse) GRLsLGAsRGSSVES S371-p
TAK1 iso3 (mouse) GRLSLGASRGSSVES S371
TAK1 (rat) GRLSLGASRGSSVES S371
S375-p
LGAsRGSsVESLPPT
0 1
TAK1 (human) LGAsRGSsVESLPPT S375-p
TAK1 iso2 (human) LGASRGSSVESLPPT S375
TAK1 (mouse) LGAsRGSSVESLPPT S375
TAK1 iso3 (mouse) LGASRGSSVESLPPT S375
TAK1 (rat) LGASRGSSVESLPPT S375
K386-ac
LPPTSEGkRMsADMs
0 1
TAK1 (human) LPPTSEGkRMsADMs K386-ac
TAK1 iso2 (human) LPPTSEGKRMSADMS K386
TAK1 (mouse) LPPTSEGKRMsADMs K386
TAK1 iso3 (mouse) LPPTSEGKRMSADMS K386
TAK1 (rat) LPPTSEGKRMsADMS K386
S389-p
TSEGkRMsADMsEIE
Upstream
1 49
Treatment
  • calyculin_A
  • isoproterenol
TAK1 (human) TSEGkRMsADMsEIE S389-p
TAK1 iso2 (human) TSEGKRMSADMSEIE S389
TAK1 (mouse) TSEGKRMsADMsEIE S389-p
TAK1 iso3 (mouse) TSEGKRMSADMSEIE S389
TAK1 (rat) TSEGKRMsADMSEIE S389-p
S393-p
kRMsADMsEIEARIA
0 2
TAK1 (human) kRMsADMsEIEARIA S393-p
TAK1 iso2 (human) KRMSADMSEIEARIA S393
TAK1 (mouse) KRMsADMsEIEARIV S393-p
TAK1 iso3 (mouse) KRMSADMSEIEARIV S393
TAK1 (rat) KRMsADMSEIEARIV S393
Y405-p
RIAATTAysKPKRGH
0 9
TAK1 (human) RIAATTAysKPKRGH Y405-p
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) RIVATAAySKPKRGH Y405-p
TAK1 (rat) RIVATTAYTKPKRGH Y405
S406-p
IAATTAysKPKRGHR
0 1
TAK1 (human) IAATTAysKPKRGHR S406-p
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) IVATAAySKPKRGHR S406
TAK1 (rat) IVATTAYTKPKRGHR T406
T415-p
PKRGHRKtAsFGNIL
0 3
TAK1 (human) PKRGHRKtAsFGNIL T415-p
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) PKRGHRKtAsFGNIL T415-p
TAK1 (rat) PKRGHRKTAsFGNIL T415
S417-p
RGHRKtAsFGNILDV
0 9
TAK1 (human) RGHRKtAsFGNILDV S417-p
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) RGHRKtAsFGNILDV S417-p
TAK1 (rat) RGHRKTAsFGNILDV S417-p
S439-p
NGQPRRRsIQDLtVT
Upstream
Downstream
5 146
TAK1 (human)
S439-p
TAK1 (mouse)
S412-p
TAK1 (rat)
S439-p
Effects on Modified Protein
  • molecular association, regulation
Phosphatases, in vitro:
  • PPP2CA (human)
Putative upstream phosphatases:
  • PPP2CA (mouse)
Regulatory protein:
  • TAK1 (human)
Treatment
  • bacterial infection
  • metastatic potential
  • MG132_withdrawal
  • nocodazole
  • okadaic_acid
  • SB202190
  • SII_angiotensin_2
TAK1 (human) NGQPRRRsIQDLtVT S439-p
TAK1 iso2 (human) NGQPRRRSIQDLTVT S412
TAK1 (mouse) NGQPRRRsIQDLtVT S412-p
TAK1 iso3 (mouse) NGQPRRRsIQDLTVT S439-p
TAK1 (rat) NGQPRRRsIQDLTVT S439-p
T444-p
RRsIQDLtVTGtEPG
Upstream
Downstream
1 5
Effects on Modified Protein
  • molecular association, regulation
Regulatory protein:
  • TAK1 (human)
Treatment
  • (5Z)-7-oxozeaenol
  • bacterial infection
  • calyculin_A
TAK1 (human) RRsIQDLtVTGtEPG T444-p
TAK1 iso2 (human) RRSIQDLTVTGTEPG T417
TAK1 (mouse) RRsIQDLtVTGTEPG T417-p
TAK1 iso3 (mouse) RRsIQDLTVTGTEPG T444
TAK1 (rat) RRsIQDLTVTGTEPG T444
T448-p
QDLtVTGtEPGQVss
0 1
TAK1 (human) QDLtVTGtEPGQVss T448-p
TAK1 iso2 (human) QDLTVTGTEPGQVSS T421
TAK1 (mouse) QDLtVTGTEPGQVss T421
TAK1 iso3 (mouse) QDLTVTGTEPGQVSS T448
TAK1 (rat) QDLTVTGTEPGQVSS T448
S454-p
GtEPGQVssRSssPS
0 5
TAK1 (human) GtEPGQVssRSssPS S454-p
TAK1 iso2 (human) GTEPGQVSSRSSSPS S427
TAK1 (mouse) GTEPGQVssRSssPS S427-p
TAK1 iso3 (mouse) GTEPGQVSSRSSSPS S454
TAK1 (rat) GTEPGQVSSRSSSPS S454
S454
GtEPGQVSsRSssPS
1 1
TAK1 (human) GtEPGQVSsRSssPS S454
TAK1 iso2 (human) GTEPGQVSSRSSSPS S427
TAK1 (mouse) GTEPGQVssRSssPS S427-gl
TAK1 iso3 (mouse) GTEPGQVSSRSSSPS S454
TAK1 (rat) GTEPGQVSSRSSSPS S454
S455-p
tEPGQVssRSssPSV
Upstream
0 10
Regulatory protein:
  • TAK1 (human)
Treatment
  • bacterial infection
  • vemurafenib
TAK1 (human) tEPGQVssRSssPSV S455-p
TAK1 iso2 (human) TEPGQVSSRSSSPSV S428
TAK1 (mouse) TEPGQVssRSssPSV S428-p
TAK1 iso3 (mouse) TEPGQVSSRSSSPSV S455
TAK1 (rat) TEPGQVSSRSSSPSV S455
S458-p
GQVssRSssPSVRMI
0 2
TAK1 (human) GQVssRSssPSVRMI S458-p
TAK1 iso2 (human) GQVSSRSSSPSVRMI S431
TAK1 (mouse) GQVssRSssPSVRMI S431-p
TAK1 iso3 (mouse) GQVSSRSSSPSVRMI S458
TAK1 (rat) GQVSSRSSSPSVRMI S458
S459-p
QVssRSssPSVRMIT
0 3
TAK1 (human) QVssRSssPSVRMIT S459-p
TAK1 iso2 (human) QVSSRSSSPSVRMIT S432
TAK1 (mouse) QVssRSssPSVRMIT S432-p
TAK1 iso3 (mouse) QVSSRSSSPSVRMIT S459
TAK1 (rat) QVSSRSSSPSVRMIT S459
T471-p
MITTSGPtsEkPTRS
Upstream
1 1
Treatment
  • calyculin_A
TAK1 (human) MITTSGPtsEkPTRS T471-p
TAK1 iso2 (human) MITTSGPTSEKPTRS T444
TAK1 (mouse) MITTSGPTSEKPARS T444
TAK1 iso3 (mouse) MITTSGPTSEKPARS T471
TAK1 (rat) MITTSGPTSEKPARS T471
S472-p
ITTSGPtsEkPTRSH
0 1
TAK1 (human) ITTSGPtsEkPTRSH S472-p
TAK1 iso2 (human) ITTSGPTSEKPTRSH S445
TAK1 (mouse) ITTSGPTSEKPARSH S445
TAK1 iso3 (mouse) ITTSGPTSEKPARSH S472
TAK1 (rat) ITTSGPTSEKPARSL S472
K474-ub
TSGPtsEkPTRSHPW
0 3
TAK1 (human) TSGPtsEkPTRSHPW K474-ub
TAK1 iso2 (human) TSGPTSEKPTRSHPW K447
TAK1 (mouse) TSGPTSEKPARSHPW K447
TAK1 iso3 (mouse) TSGPTSEKPARSHPW K474
TAK1 (rat) TSGPTSEKPARSLPW K474
S492
DSTDTNGSDNSIPMA
0 1
TAK1 (human) DSTDTNGSDNSIPMA S492
TAK1 iso2 (human) DSTDTNGSDNSIPMA S465
TAK1 (mouse) DSTDTNGsDNSIPMA S465-p
TAK1 iso3 (mouse) DSTDTNGSDNSIPMA S492
TAK1 (rat) DSTDTNGSDNSIPMA S492
T538-p
QEYMKVQtEIALLLQ
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • calyculin_A
TAK1 (human) QEYMKVQtEIALLLQ T538-p
TAK1 iso2 (human) QEYMKVQTEIALLLQ T511
TAK1 (mouse) QEYMKVQTEIALLLQ T511
TAK1 iso3 (mouse) QEYMKVQTEIALLLQ T538
TAK1 (rat) QEYMKVQTEIALLLQ T538
K547-ub
IALLLQRkQELVAEL
0 2
TAK1 (human) IALLLQRkQELVAEL K547-ub
TAK1 iso2 (human) IALLLQRKQELVAEL K520
TAK1 (mouse) IALLLQRKQELVAEL K520
TAK1 iso3 (mouse) IALLLQRKQELVAEL K547
TAK1 (rat) IALLLQRKQELVAEL K547
K573-ac
RLVQEHKkLLDENkS
0 1
TAK1 (human) RLVQEHKkLLDENkS K573-ac
TAK1 iso2 (human) RLVQEHKKLLDENKS K546
TAK1 (mouse) RLVQEHKKLLDENKS K546
TAK1 iso3 (mouse) RLVQEHKKLLDENKS K573
TAK1 (rat) RLVQEHKKLLDENKS K573
K579-ub
KkLLDENkSLSTyyQ
0 2
TAK1 (human) KkLLDENkSLSTyyQ K579-ub
TAK1 iso2 (human) KKLLDENKSLSTYYQ K552
TAK1 (mouse) KKLLDENKSLSTYYQ K552
TAK1 iso3 (mouse) KKLLDENKSLSTYYQ K579
TAK1 (rat) KKLLDENKSLSTYYQ K579
Y584-p
ENkSLSTyyQQCKkQ
0 2
TAK1 (human) ENkSLSTyyQQCKkQ Y584-p
TAK1 iso2 (human) ENKSLSTYYQQCKKQ Y557
TAK1 (mouse) ENKSLSTYYQQCKkQ Y557
TAK1 iso3 (mouse) ENKSLSTYYQQCKKQ Y584
TAK1 (rat) ENKSLSTYYQQCKKQ Y584
Y585-p
NkSLSTyyQQCKkQL
0 2
TAK1 (human) NkSLSTyyQQCKkQL Y585-p
TAK1 iso2 (human) NKSLSTYYQQCKKQL Y558
TAK1 (mouse) NKSLSTYYQQCKkQL Y558
TAK1 iso3 (mouse) NKSLSTYYQQCKKQL Y585
TAK1 (rat) NKSLSTYYQQCKKQL Y585
K590-ub
TyyQQCKkQLEVIRS
0 5
TAK1 (human) TyyQQCKkQLEVIRS K590-ub
TAK1 iso2 (human) TYYQQCKKQLEVIRS K563
TAK1 (mouse) TYYQQCKkQLEVIRS K563-ub
TAK1 iso3 (mouse) TYYQQCKKQLEVIRS K590
TAK1 (rat) TYYQQCKKQLEVIRS K590