Other Species / Isoforms
  TAK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T178
LKICDFGtACDIQtH
Upstream
Downstream
2 0
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative in vivo kinases:
  • TAK1 (human)
Treatment
  • IL-1b
TAK1 (human) LKICDFGtACDIQtH T178
TAK1 iso2 (human) LKICDFGTACDIQTH T178
TAK1 (mouse) LKICDFGTACDIQtH T178
TAK1 iso3 (mouse) LKICDFGTACDIQtH T178
TAK1 (rat) LKICDFGTACDIQTH T178
T184
GtACDIQtHMtNNKG
Upstream
Downstream
16 0
TAK1 (human)
T184
TAK1 (mouse)
T184
TAK1 (rat)
T184
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • TAK1 (human)
Putative in vivo kinases:
  • TAK1 (human)
Regulatory protein:
  • AlphaK3 (human)
  • ATM (human)
  • Bcl-10 (human)
  • CLASP1 (human)
  • DUSP14 (human)
  • IRF6 (human)
  • RALBP1 (human)
  • TAB1 (human)
  • TAB2 (human)
  • TIFA (human)
  • TRAF6 (human)
  • UBE2N (human)
Treatment
  • BAPTA-AM
  • carrageenan
  • high_cell_density
  • IL-1b
  • ionizing_radiation
  • ionomycin
  • phorbol_ester
  • TAK1_inhibitor
  • TNF
TAK1 (human) GtACDIQtHMtNNKG T184
TAK1 iso2 (human) GTACDIQTHMTNNKG T184
TAK1 (mouse) GTACDIQtHMtNNKG T184
TAK1 iso3 (mouse) GTACDIQtHMtNNKG T184
TAK1 (rat) GTACDIQTHMtNNKG T184
T187
CDIQtHMtNNKGsAA
Upstream
Downstream
25 1
TAK1 (human)
T187
TAK1 (mouse)
T187
TAK1 (rat)
T187
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
  • transcription, altered
Kinase, in vitro:
  • TAK1 (human)
Phosphatases, in vitro:
  • PPP2CA (human)
Putative in vivo kinases:
  • TAK1 (human)
  • TAK1 (mouse)
Putative upstream phosphatases:
  • PPP2CA (mouse)
Regulatory protein:
  • AlphaK3 (human)
  • ATM (human)
  • Bcl-10 (human)
  • CLASP1 (human)
  • DUSP14 (human)
  • IRF6 (human)
  • P38A (human)
  • PPP2CA (mouse)
  • RALBP1 (human)
  • TAB1 (human)
  • TAB2 (human)
  • TIFA (human)
  • TRAF6 (human)
  • UBE2N (human)
  • yopJ (bacteria)
Treatment
  • anisomycin
  • bacterial infection
  • BAPTA-AM
  • calyculin_A
  • carrageenan
  • ciclosporin
  • EGF
  • ethanol
  • gomisin_A
  • gomisin_N
  • high_cell_density
  • hypertonic_buffer
  • IL-1a
  • ionizing_radiation
  • ionomycin
  • okadaic_acid
  • phorbol_ester
  • SB203580
  • siRNA
  • TAK1_inhibitor
  • tautomycin
  • TGF-beta
  • TNF
TAK1 (human) CDIQtHMtNNKGsAA T187
TAK1 iso2 (human) CDIQTHMTNNKGSAA T187
TAK1 (mouse) CDIQtHMtNNKGsAA T187
TAK1 iso3 (mouse) CDIQtHMtNNKGSAA T187
TAK1 (rat) CDIQTHMtNNKGSAA T187
S192
HMtNNKGsAAWMAPE
Upstream
Downstream
5 1
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
Putative in vivo kinases:
  • TAK1 (human)
Regulatory protein:
  • Bcl-10 (human)
Treatment
  • carrageenan
TAK1 (human) HMtNNKGsAAWMAPE S192
TAK1 iso2 (human) HMTNNKGSAAWMAPE S192
TAK1 (mouse) HMtNNKGsAAWMAPE S192
TAK1 iso3 (mouse) HMtNNKGSAAWMAPE S192
TAK1 (rat) HMtNNKGSAAWMAPE S192
Y206
EVFEGSNySEKCDVF
Upstream
Downstream
1 0
Effects on Modified Protein
  • phosphorylation
  • ubiquitination
Putative upstream phosphatases:
  • SHP-1 (human)
TAK1 (human) EVFEGSNySEKCDVF Y206
TAK1 iso2 (human) EVFEGSNYSEKCDVF Y206
TAK1 (mouse) EVFEGSNYSEKCDVF Y206
TAK1 iso3 (mouse) EVFEGSNYSEKCDVF Y206
TAK1 (rat) EVFEGSNYSEKCDVF Y206
T333
NTSNKSDtNMEQVPA
0 1
TAK1 (human) NTSNKSDtNMEQVPA T333
TAK1 iso2 (human) NTSNKSDTNMEQVPA T333
TAK1 (mouse) NTSNKSDTNMEQVPA T333
TAK1 iso3 (mouse) NTSNKSDTNMEQVPA T333
TAK1 (rat) NTSNKSDTNMEQVPA T333
T344
QVPATNDtIKRLESK
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • calyculin_A
TAK1 (human) QVPATNDtIKRLESK T344
TAK1 iso2 (human) QVPATNDTIKRLESK T344
TAK1 (mouse) QVPATNDTIKRLESK T344
TAK1 iso3 (mouse) QVPATNDTIKRLESK T344
TAK1 (rat) QVPATNDTIKRLESK T344
S361
KNQAKQQsESGRLsL
0 1
TAK1 (human) KNQAKQQsESGRLsL S361
TAK1 iso2 (human) KNQAKQQSESGRLSL S361
TAK1 (mouse) KNQAKQQsESGRLsL S361
TAK1 iso3 (mouse) KNQAKQQSESGRLSL S361
TAK1 (rat) KNQAKQQSDSGRLSL S361
S367
QsESGRLsLGAsRGS
0 6
TAK1 (human) QsESGRLsLGAsRGS S367
TAK1 iso2 (human) QSESGRLSLGASRGS S367
TAK1 (mouse) QsESGRLsLGAsRGS S367
TAK1 iso3 (mouse) QSESGRLSLGASRGS S367
TAK1 (rat) QSDSGRLSLGASRGS S367
S371
GRLsLGAsRGSsVES
0 6
TAK1 (human) GRLsLGAsRGSsVES S371
TAK1 iso2 (human) GRLSLGASRGSSVES S371
TAK1 (mouse) GRLsLGAsRGSSVES S371
TAK1 iso3 (mouse) GRLSLGASRGSSVES S371
TAK1 (rat) GRLSLGASRGSSVES S371
S375
LGAsRGSsVESLPPT
0 1
TAK1 (human) LGAsRGSsVESLPPT S375
TAK1 iso2 (human) LGASRGSSVESLPPT S375
TAK1 (mouse) LGAsRGSSVESLPPT S375
TAK1 iso3 (mouse) LGASRGSSVESLPPT S375
TAK1 (rat) LGASRGSSVESLPPT S375
S389
TSEGKRMsADMsEIE
Upstream
1 49
Treatment
  • calyculin_A
  • isoproterenol
TAK1 (human) TSEGKRMsADMsEIE S389
TAK1 iso2 (human) TSEGKRMSADMSEIE S389
TAK1 (mouse) TSEGKRMsADMsEIE S389
TAK1 iso3 (mouse) TSEGKRMSADMSEIE S389
TAK1 (rat) TSEGKRMsADMSEIE S389
S393
KRMsADMsEIEARIA
0 2
TAK1 (human) KRMsADMsEIEARIA S393
TAK1 iso2 (human) KRMSADMSEIEARIA S393
TAK1 (mouse) KRMsADMsEIEARIV S393
TAK1 iso3 (mouse) KRMSADMSEIEARIV S393
TAK1 (rat) KRMsADMSEIEARIV S393
Y405
RIAATTAysKPKRGH
0 9
TAK1 (human) RIAATTAysKPKRGH Y405
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) RIVATAAySKPKRGH Y405
TAK1 (rat) RIVATTAYTKPKRGH Y405
S406
IAATTAysKPKRGHR
0 1
TAK1 (human) IAATTAysKPKRGHR S406
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) IVATAAySKPKRGHR S406
TAK1 (rat) IVATTAYTKPKRGHR T406
T415
PKRGHRKtAsFGNIL
0 3
TAK1 (human) PKRGHRKtAsFGNIL T415
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) PKRGHRKtAsFGNIL T415
TAK1 (rat) PKRGHRKTAsFGNIL T415
S417
RGHRKtAsFGNILDV
0 9
TAK1 (human) RGHRKtAsFGNILDV S417
TAK1 iso2 (human) gap -
TAK1 (mouse) gap -
TAK1 iso3 (mouse) RGHRKtAsFGNILDV S417
TAK1 (rat) RGHRKTAsFGNILDV S417
S439
NGQPRRRsIQDLtVT
Upstream
Downstream
5 146
TAK1 (human)
S439
TAK1 (mouse)
S412
TAK1 (rat)
S439
Effects on Modified Protein
  • molecular association, regulation
Phosphatases, in vitro:
  • PPP2CA (human)
Putative upstream phosphatases:
  • PPP2CA (mouse)
Regulatory protein:
  • TAK1 (human)
Treatment
  • bacterial infection
  • metastatic potential
  • MG132_withdrawal
  • nocodazole
  • okadaic_acid
  • SB202190
  • SII_angiotensin_2
TAK1 (human) NGQPRRRsIQDLtVT S439
TAK1 iso2 (human) NGQPRRRSIQDLTVT S412
TAK1 (mouse) NGQPRRRsIQDLtVT S412
TAK1 iso3 (mouse) NGQPRRRsIQDLTVT S439
TAK1 (rat) NGQPRRRsIQDLTVT S439
T444
RRsIQDLtVTGtEPG
Upstream
Downstream
1 5
Effects on Modified Protein
  • molecular association, regulation
Regulatory protein:
  • TAK1 (human)
Treatment
  • (5Z)-7-oxozeaenol
  • bacterial infection
  • calyculin_A
TAK1 (human) RRsIQDLtVTGtEPG T444
TAK1 iso2 (human) RRSIQDLTVTGTEPG T417
TAK1 (mouse) RRsIQDLtVTGTEPG T417
TAK1 iso3 (mouse) RRsIQDLTVTGTEPG T444
TAK1 (rat) RRsIQDLTVTGTEPG T444
T448
QDLtVTGtEPGQVss
0 1
TAK1 (human) QDLtVTGtEPGQVss T448
TAK1 iso2 (human) QDLTVTGTEPGQVSS T421
TAK1 (mouse) QDLtVTGTEPGQVss T421
TAK1 iso3 (mouse) QDLTVTGTEPGQVSS T448
TAK1 (rat) QDLTVTGTEPGQVSS T448
S454
GtEPGQVssRSssPS
0 5
TAK1 (human) GtEPGQVssRSssPS S454
TAK1 iso2 (human) GTEPGQVSSRSSSPS S427
TAK1 (mouse) GTEPGQVssRSssPS S427
TAK1 iso3 (mouse) GTEPGQVSSRSSSPS S454
TAK1 (rat) GTEPGQVSSRSSSPS S454
S455
tEPGQVssRSssPSV
Upstream
0 10
Regulatory protein:
  • TAK1 (human)
Treatment
  • bacterial infection
  • vemurafenib
TAK1 (human) tEPGQVssRSssPSV S455
TAK1 iso2 (human) TEPGQVSSRSSSPSV S428
TAK1 (mouse) TEPGQVssRSssPSV S428
TAK1 iso3 (mouse) TEPGQVSSRSSSPSV S455
TAK1 (rat) TEPGQVSSRSSSPSV S455
S458
GQVssRSssPSVRMI
0 2
TAK1 (human) GQVssRSssPSVRMI S458
TAK1 iso2 (human) GQVSSRSSSPSVRMI S431
TAK1 (mouse) GQVssRSssPSVRMI S431
TAK1 iso3 (mouse) GQVSSRSSSPSVRMI S458
TAK1 (rat) GQVSSRSSSPSVRMI S458
S459
QVssRSssPSVRMIT
0 3
TAK1 (human) QVssRSssPSVRMIT S459
TAK1 iso2 (human) QVSSRSSSPSVRMIT S432
TAK1 (mouse) QVssRSssPSVRMIT S432
TAK1 iso3 (mouse) QVSSRSSSPSVRMIT S459
TAK1 (rat) QVSSRSSSPSVRMIT S459
T471
MITTSGPtsEKPTRS
Upstream
1 1
Treatment
  • calyculin_A
TAK1 (human) MITTSGPtsEKPTRS T471
TAK1 iso2 (human) MITTSGPTSEKPTRS T444
TAK1 (mouse) MITTSGPTSEKPARS T444
TAK1 iso3 (mouse) MITTSGPTSEKPARS T471
TAK1 (rat) MITTSGPTSEKPARS T471
S472
ITTSGPtsEKPTRSH
0 1
TAK1 (human) ITTSGPtsEKPTRSH S472
TAK1 iso2 (human) ITTSGPTSEKPTRSH S445
TAK1 (mouse) ITTSGPTSEKPARSH S445
TAK1 iso3 (mouse) ITTSGPTSEKPARSH S472
TAK1 (rat) ITTSGPTSEKPARSL S472
S492
DSTDTNGSDNSIPMA
0 1
TAK1 (human) DSTDTNGSDNSIPMA S492
TAK1 iso2 (human) DSTDTNGSDNSIPMA S465
TAK1 (mouse) DSTDTNGsDNSIPMA S465
TAK1 iso3 (mouse) DSTDTNGSDNSIPMA S492
TAK1 (rat) DSTDTNGSDNSIPMA S492
T538
QEYMKVQtEIALLLQ
Upstream
Downstream
1 1
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • calyculin_A
TAK1 (human) QEYMKVQtEIALLLQ T538
TAK1 iso2 (human) QEYMKVQTEIALLLQ T511
TAK1 (mouse) QEYMKVQTEIALLLQ T511
TAK1 iso3 (mouse) QEYMKVQTEIALLLQ T538
TAK1 (rat) QEYMKVQTEIALLLQ T538
Y584
ENKSLSTyyQQCKKQ
0 2
TAK1 (human) ENKSLSTyyQQCKKQ Y584
TAK1 iso2 (human) ENKSLSTYYQQCKKQ Y557
TAK1 (mouse) ENKSLSTYYQQCKKQ Y557
TAK1 iso3 (mouse) ENKSLSTYYQQCKKQ Y584
TAK1 (rat) ENKSLSTYYQQCKKQ Y584
Y585
NKSLSTyyQQCKKQL
0 2
TAK1 (human) NKSLSTyyQQCKKQL Y585
TAK1 iso2 (human) NKSLSTYYQQCKKQL Y558
TAK1 (mouse) NKSLSTYYQQCKKQL Y558
TAK1 iso3 (mouse) NKSLSTYYQQCKKQL Y585
TAK1 (rat) NKSLSTYYQQCKKQL Y585