TAK1 (human)

LTP

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

HTP

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

T178

LKICDFGtACDIQtH

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
phosphorylation

Putative in vivo kinases:

TAK1 (human)

Treatment

IL-1b

TAK1 (human)	LKICDFGtACDIQtH	T178
TAK1 iso2 (human)	LKICDFGTACDIQTH	T178
TAK1 (mouse)	LKICDFGTACDIQtH	T178
TAK1 iso3 (mouse)	LKICDFGTACDIQtH	T178
TAK1 (rat)	LKICDFGTACDIQTH	T178

T184

GtACDIQtHMtNNKG

Upstream

Downstream

TAK1 (human)
T184

TAK1 (mouse)
T184

TAK1 (rat)
T184

Effects on Modified Protein

enzymatic activity, induced
phosphorylation

Effects on Biological Processes:

signaling pathway regulation

Kinase, in vitro:

TAK1 (human)

Putative in vivo kinases:

TAK1 (human)

Regulatory protein:

AlphaK3 (human)
ATM (human)
Bcl-10 (human)
CLASP1 (human)
DUSP14 (human)
IRF6 (human)
RALBP1 (human)
TAB1 (human)
TAB2 (human)
TIFA (human)
TRAF6 (human)
UBE2N (human)

Treatment

BAPTA-AM
carrageenan
high_cell_density
IL-1b
ionizing_radiation
ionomycin
phorbol_ester
TAK1_inhibitor
TNF

TAK1 (human)	GtACDIQtHMtNNKG	T184
TAK1 iso2 (human)	GTACDIQTHMTNNKG	T184
TAK1 (mouse)	GTACDIQtHMtNNKG	T184
TAK1 iso3 (mouse)	GTACDIQtHMtNNKG	T184
TAK1 (rat)	GTACDIQTHMtNNKG	T184

T187

CDIQtHMtNNKGsAA

Upstream

Downstream

TAK1 (human)
T187

TAK1 (mouse)
T187

TAK1 (rat)
T187

Effects on Modified Protein

enzymatic activity, induced
phosphorylation

Effects on Biological Processes:

signaling pathway regulation
transcription, altered

Kinase, in vitro:

TAK1 (human)

Phosphatases, in vitro:

PPP2CA (human)

Putative in vivo kinases:

TAK1 (human)
TAK1 (mouse)

Putative upstream phosphatases:

PPP2CA (mouse)

Regulatory protein:

AlphaK3 (human)
ATM (human)
Bcl-10 (human)
CLASP1 (human)
DUSP14 (human)
IRF6 (human)
P38A (human)
PPP2CA (mouse)
RALBP1 (human)
TAB1 (human)
TAB2 (human)
TIFA (human)
TRAF6 (human)
UBE2N (human)
yopJ (bacteria)

Treatment

anisomycin
bacterial infection
BAPTA-AM
calyculin_A
carrageenan
ciclosporin
EGF
ethanol
gomisin_A
gomisin_N
high_cell_density
hypertonic_buffer
IL-1a
ionizing_radiation
ionomycin
okadaic_acid
phorbol_ester
SB203580
siRNA
TAK1_inhibitor
tautomycin
TGF-beta
TNF

TAK1 (human)	CDIQtHMtNNKGsAA	T187
TAK1 iso2 (human)	CDIQTHMTNNKGSAA	T187
TAK1 (mouse)	CDIQtHMtNNKGsAA	T187
TAK1 iso3 (mouse)	CDIQtHMtNNKGSAA	T187
TAK1 (rat)	CDIQTHMtNNKGSAA	T187

S192

HMtNNKGsAAWMAPE

Upstream

Downstream

Effects on Modified Protein

enzymatic activity, induced
phosphorylation

Putative in vivo kinases:

TAK1 (human)

Regulatory protein:

Bcl-10 (human)

Treatment

carrageenan

TAK1 (human)	HMtNNKGsAAWMAPE	S192
TAK1 iso2 (human)	HMTNNKGSAAWMAPE	S192
TAK1 (mouse)	HMtNNKGsAAWMAPE	S192
TAK1 iso3 (mouse)	HMtNNKGSAAWMAPE	S192
TAK1 (rat)	HMtNNKGSAAWMAPE	S192

Y206

EVFEGSNySEKCDVF

Upstream

Downstream

Effects on Modified Protein

phosphorylation
ubiquitination

Putative upstream phosphatases:

SHP-1 (human)

TAK1 (human)	EVFEGSNySEKCDVF	Y206
TAK1 iso2 (human)	EVFEGSNYSEKCDVF	Y206
TAK1 (mouse)	EVFEGSNYSEKCDVF	Y206
TAK1 iso3 (mouse)	EVFEGSNYSEKCDVF	Y206
TAK1 (rat)	EVFEGSNYSEKCDVF	Y206

T333

NTSNKSDtNMEQVPA

TAK1 (human)	NTSNKSDtNMEQVPA	T333
TAK1 iso2 (human)	NTSNKSDTNMEQVPA	T333
TAK1 (mouse)	NTSNKSDTNMEQVPA	T333
TAK1 iso3 (mouse)	NTSNKSDTNMEQVPA	T333
TAK1 (rat)	NTSNKSDTNMEQVPA	T333

T344

QVPATNDtIKRLESK

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Treatment

calyculin_A

TAK1 (human)	QVPATNDtIKRLESK	T344
TAK1 iso2 (human)	QVPATNDTIKRLESK	T344
TAK1 (mouse)	QVPATNDTIKRLESK	T344
TAK1 iso3 (mouse)	QVPATNDTIKRLESK	T344
TAK1 (rat)	QVPATNDTIKRLESK	T344

S361

KNQAKQQsESGRLsL

TAK1 (human)	KNQAKQQsESGRLsL	S361
TAK1 iso2 (human)	KNQAKQQSESGRLSL	S361
TAK1 (mouse)	KNQAKQQsESGRLsL	S361
TAK1 iso3 (mouse)	KNQAKQQSESGRLSL	S361
TAK1 (rat)	KNQAKQQSDSGRLSL	S361

S367

QsESGRLsLGAsRGS

TAK1 (human)	QsESGRLsLGAsRGS	S367
TAK1 iso2 (human)	QSESGRLSLGASRGS	S367
TAK1 (mouse)	QsESGRLsLGAsRGS	S367
TAK1 iso3 (mouse)	QSESGRLSLGASRGS	S367
TAK1 (rat)	QSDSGRLSLGASRGS	S367

S371

GRLsLGAsRGSsVES

TAK1 (human)	GRLsLGAsRGSsVES	S371
TAK1 iso2 (human)	GRLSLGASRGSSVES	S371
TAK1 (mouse)	GRLsLGAsRGSSVES	S371
TAK1 iso3 (mouse)	GRLSLGASRGSSVES	S371
TAK1 (rat)	GRLSLGASRGSSVES	S371

S375

LGAsRGSsVESLPPT

TAK1 (human)	LGAsRGSsVESLPPT	S375
TAK1 iso2 (human)	LGASRGSSVESLPPT	S375
TAK1 (mouse)	LGAsRGSSVESLPPT	S375
TAK1 iso3 (mouse)	LGASRGSSVESLPPT	S375
TAK1 (rat)	LGASRGSSVESLPPT	S375

S389

TSEGKRMsADMsEIE

Upstream

Treatment

calyculin_A
isoproterenol

TAK1 (human)	TSEGKRMsADMsEIE	S389
TAK1 iso2 (human)	TSEGKRMSADMSEIE	S389
TAK1 (mouse)	TSEGKRMsADMsEIE	S389
TAK1 iso3 (mouse)	TSEGKRMSADMSEIE	S389
TAK1 (rat)	TSEGKRMsADMSEIE	S389

S393

KRMsADMsEIEARIA

TAK1 (human)	KRMsADMsEIEARIA	S393
TAK1 iso2 (human)	KRMSADMSEIEARIA	S393
TAK1 (mouse)	KRMsADMsEIEARIV	S393
TAK1 iso3 (mouse)	KRMSADMSEIEARIV	S393
TAK1 (rat)	KRMsADMSEIEARIV	S393

Y405

RIAATTAysKPKRGH

TAK1 (human)	RIAATTAysKPKRGH	Y405
TAK1 iso2 (human)	gap	-
TAK1 (mouse)	gap	-
TAK1 iso3 (mouse)	RIVATAAySKPKRGH	Y405
TAK1 (rat)	RIVATTAYTKPKRGH	Y405

S406

IAATTAysKPKRGHR

TAK1 (human)	IAATTAysKPKRGHR	S406
TAK1 iso2 (human)	gap	-
TAK1 (mouse)	gap	-
TAK1 iso3 (mouse)	IVATAAySKPKRGHR	S406
TAK1 (rat)	IVATTAYTKPKRGHR	T406

T415

PKRGHRKtAsFGNIL

TAK1 (human)	PKRGHRKtAsFGNIL	T415
TAK1 iso2 (human)	gap	-
TAK1 (mouse)	gap	-
TAK1 iso3 (mouse)	PKRGHRKtAsFGNIL	T415
TAK1 (rat)	PKRGHRKTAsFGNIL	T415

S417

RGHRKtAsFGNILDV

TAK1 (human)	RGHRKtAsFGNILDV	S417
TAK1 iso2 (human)	gap	-
TAK1 (mouse)	gap	-
TAK1 iso3 (mouse)	RGHRKtAsFGNILDV	S417
TAK1 (rat)	RGHRKTAsFGNILDV	S417

S439

NGQPRRRsIQDLtVT

Upstream

Downstream

146

TAK1 (human)
S439

9339 : Phospho-TAK1 (Ser412) Antibody

TAK1 (mouse)
S412

9339 : Phospho-TAK1 (Ser412) Antibody

TAK1 (rat)
S439

9339 : Phospho-TAK1 (Ser412) Antibody

Effects on Modified Protein

molecular association, regulation

Phosphatases, in vitro:

PPP2CA (human)

Putative upstream phosphatases:

PPP2CA (mouse)

Regulatory protein:

TAK1 (human)

Treatment

bacterial infection
metastatic potential
MG132_withdrawal
nocodazole
okadaic_acid
SB202190
SII_angiotensin_2

TAK1 (human)	NGQPRRRsIQDLtVT	S439
TAK1 iso2 (human)	NGQPRRRSIQDLTVT	S412
TAK1 (mouse)	NGQPRRRsIQDLtVT	S412
TAK1 iso3 (mouse)	NGQPRRRsIQDLTVT	S439
TAK1 (rat)	NGQPRRRsIQDLTVT	S439

T444

RRsIQDLtVTGtEPG

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Regulatory protein:

TAK1 (human)

Treatment

(5Z)-7-oxozeaenol
bacterial infection
calyculin_A

TAK1 (human)	RRsIQDLtVTGtEPG	T444
TAK1 iso2 (human)	RRSIQDLTVTGTEPG	T417
TAK1 (mouse)	RRsIQDLtVTGTEPG	T417
TAK1 iso3 (mouse)	RRsIQDLTVTGTEPG	T444
TAK1 (rat)	RRsIQDLTVTGTEPG	T444

T448

QDLtVTGtEPGQVss

TAK1 (human)	QDLtVTGtEPGQVss	T448
TAK1 iso2 (human)	QDLTVTGTEPGQVSS	T421
TAK1 (mouse)	QDLtVTGTEPGQVss	T421
TAK1 iso3 (mouse)	QDLTVTGTEPGQVSS	T448
TAK1 (rat)	QDLTVTGTEPGQVSS	T448

S454

GtEPGQVssRSssPS

TAK1 (human)	GtEPGQVssRSssPS	S454
TAK1 iso2 (human)	GTEPGQVSSRSSSPS	S427
TAK1 (mouse)	GTEPGQVssRSssPS	S427
TAK1 iso3 (mouse)	GTEPGQVSSRSSSPS	S454
TAK1 (rat)	GTEPGQVSSRSSSPS	S454

S455

tEPGQVssRSssPSV

Upstream

Regulatory protein:

TAK1 (human)

Treatment

bacterial infection
vemurafenib

TAK1 (human)	tEPGQVssRSssPSV	S455
TAK1 iso2 (human)	TEPGQVSSRSSSPSV	S428
TAK1 (mouse)	TEPGQVssRSssPSV	S428
TAK1 iso3 (mouse)	TEPGQVSSRSSSPSV	S455
TAK1 (rat)	TEPGQVSSRSSSPSV	S455

S458

GQVssRSssPSVRMI

TAK1 (human)	GQVssRSssPSVRMI	S458
TAK1 iso2 (human)	GQVSSRSSSPSVRMI	S431
TAK1 (mouse)	GQVssRSssPSVRMI	S431
TAK1 iso3 (mouse)	GQVSSRSSSPSVRMI	S458
TAK1 (rat)	GQVSSRSSSPSVRMI	S458

S459

QVssRSssPSVRMIT

TAK1 (human)	QVssRSssPSVRMIT	S459
TAK1 iso2 (human)	QVSSRSSSPSVRMIT	S432
TAK1 (mouse)	QVssRSssPSVRMIT	S432
TAK1 iso3 (mouse)	QVSSRSSSPSVRMIT	S459
TAK1 (rat)	QVSSRSSSPSVRMIT	S459

T471

MITTSGPtsEKPTRS

Upstream

Treatment

calyculin_A

TAK1 (human)	MITTSGPtsEKPTRS	T471
TAK1 iso2 (human)	MITTSGPTSEKPTRS	T444
TAK1 (mouse)	MITTSGPTSEKPARS	T444
TAK1 iso3 (mouse)	MITTSGPTSEKPARS	T471
TAK1 (rat)	MITTSGPTSEKPARS	T471

S472

ITTSGPtsEKPTRSH

TAK1 (human)	ITTSGPtsEKPTRSH	S472
TAK1 iso2 (human)	ITTSGPTSEKPTRSH	S445
TAK1 (mouse)	ITTSGPTSEKPARSH	S445
TAK1 iso3 (mouse)	ITTSGPTSEKPARSH	S472
TAK1 (rat)	ITTSGPTSEKPARSL	S472

S492

DSTDTNGSDNSIPMA

TAK1 (human)	DSTDTNGSDNSIPMA	S492
TAK1 iso2 (human)	DSTDTNGSDNSIPMA	S465
TAK1 (mouse)	DSTDTNGsDNSIPMA	S465
TAK1 iso3 (mouse)	DSTDTNGSDNSIPMA	S492
TAK1 (rat)	DSTDTNGSDNSIPMA	S492

T538

QEYMKVQtEIALLLQ

Upstream

Downstream

Effects on Modified Protein

molecular association, regulation

Treatment

calyculin_A

TAK1 (human)	QEYMKVQtEIALLLQ	T538
TAK1 iso2 (human)	QEYMKVQTEIALLLQ	T511
TAK1 (mouse)	QEYMKVQTEIALLLQ	T511
TAK1 iso3 (mouse)	QEYMKVQTEIALLLQ	T538
TAK1 (rat)	QEYMKVQTEIALLLQ	T538

Y584

ENKSLSTyyQQCKKQ

TAK1 (human)	ENKSLSTyyQQCKKQ	Y584
TAK1 iso2 (human)	ENKSLSTYYQQCKKQ	Y557
TAK1 (mouse)	ENKSLSTYYQQCKKQ	Y557
TAK1 iso3 (mouse)	ENKSLSTYYQQCKKQ	Y584
TAK1 (rat)	ENKSLSTYYQQCKKQ	Y584

Y585

NKSLSTyyQQCKKQL

TAK1 (human)	NKSLSTyyQQCKKQL	Y585
TAK1 iso2 (human)	NKSLSTYYQQCKKQL	Y558
TAK1 (mouse)	NKSLSTYYQQCKKQL	Y558
TAK1 iso3 (mouse)	NKSLSTYYQQCKKQL	Y585
TAK1 (rat)	NKSLSTYYQQCKKQL	Y585