Y14
|
DSANHLTyFFGNITR
|
|
|
1
|
1
|
|
|
Syk (human)
|
DSANHLPFFFGNITR
|
F15
|
Syk iso2 (human)
|
DSANHLPFFFGNITR
|
F15
|
Syk (mouse)
|
DSANHLTyFFGNITR
|
Y14
|
Syk (rat)
|
DNANHLTYFFGNITR
|
Y14
|
|
Y27
|
TREEAEDyLVQGGMT
|
|
|
1
|
4
|
|
|
Syk (human)
|
TREEAEDyLVQGGMS
|
Y28
|
Syk iso2 (human)
|
TREEAEDYLVQGGMS
|
Y28
|
Syk (mouse)
|
TREEAEDyLVQGGMT
|
Y27
|
Syk (rat)
|
TREEAEDYLVQGGMT
|
Y27
|
|
Y46
|
LLRQSRNyLGGFALS
|
Upstream
|
|
1
|
3
|
|
|
|
Syk (human)
|
LLRQSRNyLGGFALS
|
Y47
|
Syk iso2 (human)
|
LLRQSRNYLGGFALS
|
Y47
|
Syk (mouse)
|
LLRQSRNyLGGFALS
|
Y46
|
Syk (rat)
|
LLRQSRNYLGGFALS
|
Y46
|
|
Y63
|
HNRKAHHyTIERELN
|
|
|
1
|
1
|
|
|
Syk (human)
|
HGRKAHHYTIERELN
|
Y64
|
Syk iso2 (human)
|
HGRKAHHYTIERELN
|
Y64
|
Syk (mouse)
|
HNRKAHHyTIERELN
|
Y63
|
Syk (rat)
|
HNRKAHHYTIERELN
|
Y63
|
|
T72
|
IERELNGTyAISGGR
|
|
|
0
|
1
|
|
|
Syk (human)
|
IERELNGtyAIAGGR
|
T73
|
Syk iso2 (human)
|
IERELNGTYAIAGGR
|
T73
|
Syk (mouse)
|
IERELNGTyAISGGR
|
T72
|
Syk (rat)
|
IERELNGTYAISGGR
|
T72
|
|
Y73
|
ERELNGTyAISGGRA
|
|
|
1
|
54
|
|
|
Syk (human)
|
ERELNGtyAIAGGRT
|
Y74
|
Syk iso2 (human)
|
ERELNGTYAIAGGRT
|
Y74
|
Syk (mouse)
|
ERELNGTyAISGGRA
|
Y73
|
Syk (rat)
|
ERELNGTYAISGGRA
|
Y73
|
|
Y90
|
SPADLCHyHSQEPDG
|
|
|
1
|
3
|
|
|
Syk (human)
|
SPADLCHyHSQESDG
|
Y91
|
Syk iso2 (human)
|
SPADLCHYHSQESDG
|
Y91
|
Syk (mouse)
|
SPADLCHyHSQEPDG
|
Y90
|
Syk (rat)
|
SPADLCHYHSQEPEG
|
Y90
|
|
Y130
|
KENLIREyVKQTWNL
|
Upstream
|
Downstream
|
7
|
3
|
|
|
Effects on Modified Protein
- molecular association, regulation
- protein conformation
|
|
Kinase, in vitro:
|
Putative in vivo kinases:
|
Treatment
- antibody
- H2O2
- IL-33
- vanadate
|
|
Syk (human)
|
KENLIREYVKQTWNL
|
Y131
|
Syk iso2 (human)
|
KENLIREYVKQTWNL
|
Y131
|
Syk (mouse)
|
KENLIREyVKQTWNL
|
Y130
|
Syk (rat)
|
KENLIREyVKQTWNL
|
Y130
|
|
T160
|
LEKLIATTAHEKMPW
|
|
|
0
|
1
|
|
|
Syk (human)
|
LEKLIATtAHEKMPW
|
T161
|
Syk iso2 (human)
|
LEKLIATTAHEKMPW
|
T161
|
Syk (mouse)
|
LEKLIATTAHEKMPW
|
T160
|
Syk (rat)
|
LEKLIATTAHEKMPW
|
T160
|
|
S177
|
GNISRDESEQTVLIG
|
|
|
1
|
0
|
|
|
Syk (human)
|
GKISREEsEQIVLIG
|
S178
|
Syk iso2 (human)
|
GKISREESEQIVLIG
|
S178
|
Syk (mouse)
|
GNISRDESEQTVLIG
|
S177
|
Syk (rat)
|
GNISRDESEQTVLIG
|
S177
|
|
S201
|
RARDNSGsyALCLLH
|
|
|
0
|
2
|
|
|
Syk (human)
|
RARDNNGsyALCLLH
|
S202
|
Syk iso2 (human)
|
RARDNNGSYALCLLH
|
S202
|
Syk (mouse)
|
RARDNSGsyALCLLH
|
S201
|
Syk (rat)
|
RARDNNGSFALCLLH
|
S201
|
|
Y202
|
ARDNSGsyALCLLHE
|
|
|
1
|
32
|
|
|
Syk (human)
|
ARDNNGsyALCLLHE
|
Y203
|
Syk iso2 (human)
|
ARDNNGSYALCLLHE
|
Y203
|
Syk (mouse)
|
ARDNSGsyALCLLHE
|
Y202
|
Syk (rat)
|
ARDNNGSFALCLLHE
|
F202
|
|
Y243
|
LWQLVEHySYKPDGL
|
Upstream
|
|
1
|
3
|
|
|
|
Syk (human)
|
LWQLVEHySYKADGL
|
Y244
|
Syk iso2 (human)
|
LWQLVEHYSYKADGL
|
Y244
|
Syk (mouse)
|
LWQLVEHySYKPDGL
|
Y243
|
Syk (rat)
|
LWQLVEHYSYKPDGL
|
Y243
|
|
T255
|
DGLLRVLTVPCQKIG
|
|
|
0
|
1
|
|
|
Syk (human)
|
DGLLRVLtVPCQKIG
|
T256
|
Syk iso2 (human)
|
DGLLRVLTVPCQKIG
|
T256
|
Syk (mouse)
|
DGLLRVLTVPCQKIG
|
T255
|
Syk (rat)
|
DGLLRVLTVPCQKIG
|
T255
|
|
S270
|
AQMGHPGsPNAHPVT
|
Upstream
|
|
1
|
9
|
|
|
|
Syk (human)
|
NFGGRPQLPGSHPAT
|
L276
|
Syk iso2 (human)
|
NFGGRPQLPGSHPAS
|
L276
|
Syk (mouse)
|
AQMGHPGsPNAHPVT
|
S270
|
Syk (rat)
|
VQMGHPGSSNAHPVT
|
S270
|
|
S279
|
NAHPVTWsPGGIISR
|
|
|
1
|
3
|
|
|
Syk (human)
|
GSHPATWSAGGIISR
|
S285
|
Syk iso2 (human)
|
gap
|
-
|
Syk (mouse)
|
NAHPVTWsPGGIISR
|
S279
|
Syk (rat)
|
NAHPVTWSPGGIISR
|
S279
|
|
S289
|
GIISRIKsysFPKPG
|
Upstream
|
|
2
|
16
|
|
|
|
Syk (human)
|
GIISRIKsysFPKPG
|
S295
|
Syk iso2 (human)
|
gap
|
-
|
Syk (mouse)
|
GIISRIKsysFPKPG
|
S289
|
Syk (rat)
|
GIISRIKSYsFPKPG
|
S289
|
|
Y290
|
IISRIKsysFPKPGH
|
Upstream
|
Downstream
|
3
|
105
|
|
|
Effects on Modified Protein
- intracellular localization
|
|
|
Syk (human)
|
IISRIKsysFPKPGH
|
Y296
|
Syk iso2 (human)
|
gap
|
-
|
Syk (mouse)
|
IISRIKsysFPKPGH
|
Y290
|
Syk (rat)
|
IISRIKSYsFPKPGH
|
Y290
|
|
S291
|
ISRIKsysFPKPGHK
|
Upstream
|
Downstream
|
5
|
34
|
|
|
|
Effects on Modified Protein
- molecular association, regulation
|
|
Kinase, in vitro:
|
Treatment
- antibody
- Go_6976
- IL-33
- ischemia
- phorbol_ester
|
|
Syk (human)
|
ISRIKsysFPKPGHR
|
S297
|
Syk iso2 (human)
|
gap
|
-
|
Syk (mouse)
|
ISRIKsysFPKPGHK
|
S291
|
Syk (rat)
|
ISRIKSYsFPKPGHK
|
S291
|
|
S310
|
PQGSRPESTVSFNPy
|
|
|
0
|
1
|
|
|
Syk (human)
|
AQGNRQEsTVsFNPy
|
S316
|
Syk iso2 (human)
|
AQGNRQESTVSFNPY
|
S293
|
Syk (mouse)
|
PQGSRPESTVSFNPy
|
S310
|
Syk (rat)
|
PQGSRPESTVSFNPy
|
S310
|
|
S313
|
SRPESTVSFNPyEPt
|
|
|
0
|
3
|
|
|
Syk (human)
|
NRQEsTVsFNPyEPE
|
S319
|
Syk iso2 (human)
|
NRQESTVSFNPYEPE
|
S296
|
Syk (mouse)
|
SRPESTVSFNPyEPt
|
S313
|
Syk (rat)
|
SRPESTVSFNPyEPT
|
S313
|
|
Y317
|
STVSFNPyEPtGGPW
|
Upstream
|
Downstream
|
19
|
1048
|
|
|
|
Effects on Modified Protein
- enzymatic activity, inhibited
- molecular association, regulation
- phosphorylation
- protein conformation
|
Effects on Biological Processes:
- endocytosis, altered
- signaling pathway regulation
- transcription, altered
|
|
Kinase, in vitro:
- Lck (human)
- LYN (human)
- LYN (mouse)
- Syk (human)
- Syk (mouse)
|
Phosphatases, in vitro:
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Regulatory protein:
- CD151 (mouse)
- SH3BP2 (mouse)
- SIGLEC7 (mouse)
|
Treatment
- antibody
- antigenic stimulation
- convulxin
- fibrinogen
- H2O2
- IL-33
- LECJ
- M-CSF
- RANKL
- vanadate
- wortmannin
|
|
Syk (human)
|
sTVsFNPyEPELAPW
|
Y323
|
Syk iso2 (human)
|
STVSFNPYEPELAPW
|
Y300
|
Syk (mouse)
|
STVSFNPyEPtGGPW
|
Y317
|
Syk (rat)
|
STVSFNPyEPTGGAW
|
Y317
|
|
T320
|
SFNPyEPtGGPWGPD
|
|
|
0
|
9
|
|
|
Syk (human)
|
sFNPyEPELAPWAAD
|
E326
|
Syk iso2 (human)
|
SFNPYEPELAPWAAD
|
E303
|
Syk (mouse)
|
SFNPyEPtGGPWGPD
|
T320
|
Syk (rat)
|
SFNPyEPTGGAWGPD
|
T320
|
|
T339
|
REALPMDTEVyESPy
|
|
|
0
|
9
|
|
|
Syk (human)
|
REALPMDtEVyEsPy
|
T345
|
Syk iso2 (human)
|
REALPMDTEVYESPY
|
T322
|
Syk (mouse)
|
REALPMDTEVyESPy
|
T339
|
Syk (rat)
|
REALPMDTEVyESPy
|
T339
|
|
Y342
|
LPMDTEVyESPyADP
|
Upstream
|
Downstream
|
14
|
123
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- molecular association, regulation
- phosphorylation
|
Effects on Biological Processes:
- cell adhesion, altered
- cell motility, altered
- endocytosis, altered
- signaling pathway regulation
|
|
Kinase, in vitro:
- Lck (human)
- LYN (mouse)
- Syk (human)
- Syk (mouse)
|
Phosphatases, in vitro:
|
Regulatory protein:
|
Treatment
- antibody
- antigenic stimulation
- Bay61-3606
- BIRA766
- Collagen related peptide
- H2O2
- IL-33
- mercuric_chloride
- OXSI-2
- PP2
- PRT062607
- vanadate
- wortmannin
|
|
Syk (human)
|
LPMDtEVyEsPyADP
|
Y348
|
Syk iso2 (human)
|
LPMDTEVYESPYADP
|
Y325
|
Syk (mouse)
|
LPMDTEVyESPyADP
|
Y342
|
Syk (rat)
|
LPMDTEVyESPyADP
|
Y342
|
|
S344
|
MDTEVyESPyADPEE
|
|
|
0
|
7
|
|
|
Syk (human)
|
MDtEVyEsPyADPEE
|
S350
|
Syk iso2 (human)
|
MDTEVYESPYADPEE
|
S327
|
Syk (mouse)
|
MDTEVyESPyADPEE
|
S344
|
Syk (rat)
|
MDTEVyESPyADPEE
|
S344
|
|
Y346
|
TEVyESPyADPEEIR
|
Upstream
|
Downstream
|
39
|
269
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- enzymatic activity, inhibited
- molecular association, regulation
- phosphorylation
|
Effects on Biological Processes:
- cell adhesion, altered
- cell motility, altered
- endocytosis, altered
- signaling pathway regulation
|
|
Kinase, in vitro:
- Lck (human)
- LYN (mouse)
- Syk (human)
- Syk (mouse)
|
Phosphatases, in vitro:
- SHP-1 (human)
- STS-1 (mouse)
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Regulatory protein:
- CLEC5A (human)
- CLEC9A (human)
- FCER1A (mouse)
- HLAA (human)
- SH3BP2 (mouse)
- SHP-2 (mouse)
|
Treatment
- antibody
- antigenic stimulation
- Bay61-3606
- BIRA766
- Collagen related peptide
- convulxin
- H2O2
- M-CSF
- mercuric_chloride
- OXSI-2
- PRT062607
- R406
- RANKL
- vanadate
- wortmannin
|
|
Syk (human)
|
tEVyEsPyADPEEIR
|
Y352
|
Syk iso2 (human)
|
TEVYESPYADPEEIR
|
Y329
|
Syk (mouse)
|
TEVyESPyADPEEIR
|
Y346
|
Syk (rat)
|
TEVyESPyADPEEIR
|
Y346
|
|
Y358
|
EIRPKEVyLDRSLLT
|
Upstream
|
|
1
|
1
|
|
|
|
Syk (human)
|
EIRPKEVYLDRKLLT
|
Y364
|
Syk iso2 (human)
|
EIRPKEVYLDRKLLT
|
Y341
|
Syk (mouse)
|
EIRPKEVyLDRSLLT
|
Y358
|
Syk (rat)
|
EIRPKEVYLDRKLLT
|
Y358
|
|
S373
|
LEDNELGsGNFGTVK
|
|
|
0
|
1
|
|
|
Syk (human)
|
LEDKELGSGNFGtVK
|
S379
|
Syk iso2 (human)
|
LEDKELGSGNFGTVK
|
S356
|
Syk (mouse)
|
LEDNELGsGNFGTVK
|
S373
|
Syk (rat)
|
LEDNELGSGNFGTVK
|
S373
|
|
T378
|
LGsGNFGTVKKGyyQ
|
|
|
0
|
1
|
|
|
Syk (human)
|
LGSGNFGtVKKGYYQ
|
T384
|
Syk iso2 (human)
|
LGSGNFGTVKKGYYQ
|
T361
|
Syk (mouse)
|
LGsGNFGTVKKGyyQ
|
T378
|
Syk (rat)
|
LGSGNFGTVKKGYYQ
|
T378
|
|
Y383
|
FGTVKKGyyQMKKVV
|
|
|
0
|
1
|
|
|
Syk (human)
|
FGtVKKGYYQMKKVV
|
Y389
|
Syk iso2 (human)
|
FGTVKKGYYQMKKVV
|
Y366
|
Syk (mouse)
|
FGTVKKGyyQMKKVV
|
Y383
|
Syk (rat)
|
FGTVKKGYYQMKKVV
|
Y383
|
|
Y384
|
GTVKKGyyQMKKVVK
|
|
|
0
|
1
|
|
|
Syk (human)
|
GtVKKGYYQMKKVVK
|
Y390
|
Syk iso2 (human)
|
GTVKKGYYQMKKVVK
|
Y367
|
Syk (mouse)
|
GTVKKGyyQMKKVVK
|
Y384
|
Syk (rat)
|
GTVKKGYYQMKKVVK
|
Y384
|
|
T498
|
ARNVLLVTQHyAKIS
|
|
|
0
|
1
|
|
|
Syk (human)
|
ARNVLLVtQHyAKIS
|
T504
|
Syk iso2 (human)
|
ARNVLLVTQHYAKIS
|
T481
|
Syk (mouse)
|
ARNVLLVTQHyAKIS
|
T498
|
Syk (rat)
|
ARNVLLVTQHYAKIS
|
T498
|
|
Y501
|
VLLVTQHyAKISDFG
|
Upstream
|
|
1
|
6
|
|
|
|
Syk (human)
|
VLLVtQHyAKISDFG
|
Y507
|
Syk iso2 (human)
|
VLLVTQHYAKISDFG
|
Y484
|
Syk (mouse)
|
VLLVTQHyAKISDFG
|
Y501
|
Syk (rat)
|
VLLVTQHYAKISDFG
|
Y501
|
|
Y519
|
ALRADENyyKAQTHG
|
Upstream
|
Downstream
|
54
|
84
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- enzymatic activity, inhibited
- phosphorylation
|
Effects on Biological Processes:
|
|
Kinase, in vitro:
|
Phosphatases, in vitro:
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Regulatory protein:
- Akt1 (human)
- CARD9 (mouse)
- CD151 (mouse)
- CLEC4E (mouse)
- dectin-1 (mouse)
- FGR (human)
- GJA10 (mouse)
- PGLYRP1 (human)
- SH3BP2 (mouse)
|
Treatment
- antibody
- antigenic stimulation
- asebogenin
- bacterial infection
- bafetinib
- bafilomycin_A
- Bay61-3606
- BIRA766
- CoCl2
- Collagen related peptide
- convulxin
- CRP
- CRP-XL
- curdlan
- DMOG
- EN6
- fMLP
- GlcCers
- H2O2
- hypoxia
- IL-33
- Lipofectamine
- listeriolysin o
- M-CSF
- mercuric_chloride
- methyl-beta-cyclodextrin
- NAC
- piceatannol
- R406
- RANKL
- SCH772984
- siRNA
- TNP
- trehalose-6,6'-dimycolate
- ursolic_acid
- vanadate
- virus infection
- zalcitabine
|
|
Syk (human)
|
ALRADENyyKAQtHG
|
Y525
|
Syk iso2 (human)
|
ALRADENYYKAQTHG
|
Y502
|
Syk (mouse)
|
ALRADENyyKAQTHG
|
Y519
|
Syk (rat)
|
ALRADENyyKAQTHG
|
Y519
|
|
Y520
|
LRADENyyKAQTHGK
|
Upstream
|
Downstream
|
53
|
81
|
|
|
|
Effects on Modified Protein
- enzymatic activity, induced
- enzymatic activity, inhibited
- phosphorylation
|
Effects on Biological Processes:
|
|
Kinase, in vitro:
|
Phosphatases, in vitro:
|
Putative in vivo kinases:
|
Putative upstream phosphatases:
|
Regulatory protein:
- Akt1 (human)
- CARD9 (mouse)
- CD151 (mouse)
- CLEC4E (mouse)
- dectin-1 (mouse)
- FGR (human)
- GJA10 (mouse)
- PGLYRP1 (human)
- SH3BP2 (mouse)
|
Treatment
- antibody
- antigenic stimulation
- asebogenin
- bacterial infection
- bafetinib
- bafilomycin_A
- Bay61-3606
- BIRA766
- CoCl2
- Collagen related peptide
- convulxin
- CRP
- CRP-XL
- curdlan
- DMOG
- EN6
- fMLP
- GlcCers
- H2O2
- hypoxia
- IL-33
- Lipofectamine
- listeriolysin o
- M-CSF
- mercuric_chloride
- methyl-beta-cyclodextrin
- NAC
- piceatannol
- R406
- RANKL
- SCH772984
- siRNA
- TNP
- trehalose-6,6'-dimycolate
- ursolic_acid
- vanadate
- virus infection
- zalcitabine
|
|
Syk (human)
|
LRADENyyKAQtHGK
|
Y526
|
Syk iso2 (human)
|
LRADENYYKAQTHGK
|
Y503
|
Syk (mouse)
|
LRADENyyKAQTHGK
|
Y520
|
Syk (rat)
|
LRADENyyKAQTHGK
|
Y520
|
|
T524
|
ENyyKAQTHGKWPVK
|
|
|
0
|
1
|
|
|
Syk (human)
|
ENyyKAQtHGKWPVK
|
T530
|
Syk iso2 (human)
|
ENYYKAQTHGKWPVK
|
T507
|
Syk (mouse)
|
ENyyKAQTHGKWPVK
|
T524
|
Syk (rat)
|
ENyyKAQTHGKWPVK
|
T524
|
|
Y533
|
GKWPVKWYAPECINy
|
|
|
0
|
1
|
|
|
Syk (human)
|
GKWPVKWyAPECINy
|
Y539
|
Syk iso2 (human)
|
GKWPVKWYAPECINY
|
Y516
|
Syk (mouse)
|
GKWPVKWYAPECINy
|
Y533
|
Syk (rat)
|
GKWPVKWYAPECINY
|
Y533
|
|
Y540
|
YAPECINyYKFSSKS
|
Upstream
|
|
0
|
3
|
|
|
|
Syk (human)
|
yAPECINyYKFSSKS
|
Y546
|
Syk iso2 (human)
|
YAPECINYYKFSSKS
|
Y523
|
Syk (mouse)
|
YAPECINyYKFSSKS
|
Y540
|
Syk (rat)
|
YAPECINYFKFSSKS
|
Y540
|
|
S573
|
PYRGMKGSEVTAMLE
|
|
|
0
|
1
|
|
|
Syk (human)
|
PYRGMKGsEVTAMLE
|
S579
|
Syk iso2 (human)
|
PYRGMKGSEVTAMLE
|
S556
|
Syk (mouse)
|
PYRGMKGSEVTAMLE
|
S573
|
Syk (rat)
|
PYRGMKGSEVTAMLE
|
S573
|
|
Y623
|
VELRLRNyyyDVVN_
|
|
|
2
|
2
|
|
|
Syk (human)
|
VELRLRNyyyDVVN_
|
Y629
|
Syk iso2 (human)
|
VELRLRNYYYDVVN_
|
Y606
|
Syk (mouse)
|
VELRLRNyyyDVVN_
|
Y623
|
Syk (rat)
|
VELRLRNyyyDVVN_
|
Y623
|
|
Y624
|
ELRLRNyyyDVVN__
|
|
|
3
|
7
|
|
|
Syk (human)
|
ELRLRNyyyDVVN__
|
Y630
|
Syk iso2 (human)
|
ELRLRNYYYDVVN__
|
Y607
|
Syk (mouse)
|
ELRLRNyyyDVVN__
|
Y624
|
Syk (rat)
|
ELRLRNyyyDVVN__
|
Y624
|
|
Y625
|
LRLRNyyyDVVN___
|
|
|
3
|
4
|
|
|
Syk (human)
|
LRLRNyyyDVVN___
|
Y631
|
Syk iso2 (human)
|
LRLRNYYYDVVN___
|
Y608
|
Syk (mouse)
|
LRLRNyyyDVVN___
|
Y625
|
Syk (rat)
|
LRLRNyyyDVVN___
|
Y625
|
|