Other Species / Isoforms
  MKK4 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S5-p
___MAAPsPsGGGGS
0 2
MKK4 (human) ___MAAPsPsGGGGS S5-p
MKK4 iso2 (human) ___MAAPSPSGGGGS S5
MKK4 (mouse) ___MAAPSPSGGGGS S5
MKK4 (rat) ___MAAPSPSGGGGS S5
S7-p
_MAAPsPsGGGGSGG
0 1
MKK4 (human) _MAAPsPsGGGGSGG S7-p
MKK4 iso2 (human) _MAAPSPSGGGGSGG S7
MKK4 (mouse) _MAAPSPSGGGGSGG S7
MKK4 (rat) _MAAPSPSGGGGSGG S7
S18-p
GSGGGSGsGTPGPVG
0 1
MKK4 (human) GSGGGSGsGTPGPVG S18-p
MKK4 iso2 (human) GSGGGSGSGTPGPVG S18
MKK4 (mouse) gap -
MKK4 (rat) gap -
S26-p
GTPGPVGsPAPGHPA
0 4
MKK4 (human) GTPGPVGsPAPGHPA S26-p
MKK4 iso2 (human) GTPGPVGSPAPGHPA S26
MKK4 (mouse) GTPGPIGPPASGHPA P24
MKK4 (rat) GTPGPIGPPASGHPA P24
K42-m1
SSMQGKRkALkLNFA
0 1
MKK4 (human) SSMQGKRkALkLNFA K42-m1
MKK4 iso2 (human) EKAQSKRKALKLNFA K53
MKK4 (mouse) SSMQGKRKALKLNFA K40
MKK4 (rat) SSMQGKRKALKLNFA K40
K45-m1
QGKRkALkLNFANPP
0 2
MKK4 (human) QGKRkALkLNFANPP K45-m1
MKK4 iso2 (human) QSKRKALKLNFANPP K56
MKK4 (mouse) QGKRKALKLNFANPP K43
MKK4 (rat) QGKRKALKLNFANPP K43
K54
NFANPPFKStArFTL
0 1
MKK4 (human) NFANPPFKStArFTL K54
MKK4 iso2 (human) NFANPPFKSTARFTL K65
MKK4 (mouse) NFANPPVkStArFTL K52-ub
MKK4 (rat) NFANPPVKSTArFTL K52
K54-m1
NFANPPFkStArFTL
0 1
MKK4 (human) NFANPPFkStArFTL K54-m1
MKK4 iso2 (human) NFANPPFKSTARFTL K65
MKK4 (mouse) NFANPPVKStArFTL K52
MKK4 (rat) NFANPPVKSTArFTL K52
T56-p
ANPPFkStArFTLNP
0 4
MKK4 (human) ANPPFkStArFTLNP T56-p
MKK4 iso2 (human) ANPPFKSTARFTLNP T67
MKK4 (mouse) ANPPVkStArFTLNP T54-p
MKK4 (rat) ANPPVKSTArFTLNP T54
R58-m1
PPFkStArFTLNPNP
0 8
MKK4 (human) PPFkStArFTLNPNP R58-m1
MKK4 iso2 (human) PPFKSTARFTLNPNP R69
MKK4 (mouse) PPVkStARFTLNPNT R56
MKK4 (rat) PPVKSTArFTLNPNT R56-m1
R58-m2
PPFkStArFTLNPNP
0 19
MKK4 (human) PPFkStArFTLNPNP R58-m2
MKK4 iso2 (human) PPFKSTARFTLNPNP R69
MKK4 (mouse) PPVkStArFTLNPNT R56-m2
MKK4 (rat) PPVKSTARFTLNPNT R56
T78-p
PHIERLRtHsIESSG
0 11
MKK4 (human) PHIERLRtHsIESSG T78-p
MKK4 iso2 (human) PHIERLRTHSIESSG T89
MKK4 (mouse) PHIERLRTHsIESsG T76
MKK4 (rat) PHIERLRTHSIESSG T76
S80-p
IERLRtHsIESSGkL
Upstream
Downstream
8 102
MKK4 (human)
S80-p
MKK4 (mouse)
S78-p
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • Akt1 (human)
  • SGK1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • Akt1 (human)
  • SGK1 (human)
Treatment
  • 6-OHDA
  • angiopoietin-1
  • EGF
  • H2O2
  • insulin
  • ischemia
  • LY294002
  • TGF-beta
  • wortmannin
MKK4 (human) IERLRtHsIESSGkL S80-p
MKK4 iso2 (human) IERLRTHSIESSGKL S91
MKK4 (mouse) IERLRTHsIESsGKL S78-p
MKK4 (rat) IERLRTHSIESSGKL S78
S84
RtHsIESSGkLkIsP
0 1
MKK4 (human) RtHsIESSGkLkIsP S84
MKK4 iso2 (human) RTHSIESSGKLKISP S95
MKK4 (mouse) RTHsIESsGKLKIsP S82-p
MKK4 (rat) RTHSIESSGKLKIsP S82
K86-ub
HsIESSGkLkIsPEQ
0 1
MKK4 (human) HsIESSGkLkIsPEQ K86-ub
MKK4 iso2 (human) HSIESSGKLKISPEQ K97
MKK4 (mouse) HsIESsGKLKIsPEQ K84
MKK4 (rat) HSIESSGKLKIsPEQ K84
K88-ub
IESSGkLkIsPEQHW
0 1
MKK4 (human) IESSGkLkIsPEQHW K88-ub
MKK4 iso2 (human) IESSGKLKISPEQHW K99
MKK4 (mouse) IESsGKLKIsPEQHW K86
MKK4 (rat) IESSGKLKIsPEQHW K86
S90-p
SSGkLkIsPEQHWDF
Upstream
0 24
Treatment
  • LRRK2-IN-1
MKK4 (human) SSGkLkIsPEQHWDF S90-p
MKK4 iso2 (human) SSGKLKISPEQHWDF S101
MKK4 (mouse) SsGKLKIsPEQHWDF S88-p
MKK4 (rat) SSGKLKIsPEQHWDF S88-p
T98
PEQHWDFTAEDLkDL
0 1
MKK4 (human) PEQHWDFTAEDLkDL T98
MKK4 iso2 (human) PEQHWDFTAEDLKDL T109
MKK4 (mouse) PEQHWDFtAEDLkDL T96-p
MKK4 (rat) PEQHWDFTAEDLKDL T96
K103
DFTAEDLKDLGEIGR
0 1
MKK4 (human) DFTAEDLKDLGEIGR K103
MKK4 iso2 (human) DFTAEDLKDLGEIGR K114
MKK4 (mouse) DFtAEDLkDLGEIGR K101-ac
MKK4 (rat) DFTAEDLKDLGEIGR K101
K103-ub
DFTAEDLkDLGEIGR
0 1
MKK4 (human) DFTAEDLkDLGEIGR K103-ub
MKK4 iso2 (human) DFTAEDLKDLGEIGR K114
MKK4 (mouse) DFtAEDLKDLGEIGR K101
MKK4 (rat) DFTAEDLKDLGEIGR K101
K131-ac
SGQIMAVkRIRSTVD
0 3
MKK4 (human) SGQIMAVkRIRSTVD K131-ac
MKK4 iso2 (human) SGQIMAVKRIRSTVD K142
MKK4 (mouse) SGQIMAVKRIRSTVD K129
MKK4 (rat) SGQIMAVkRIRSTVD K129-ac
K140-ub
IRSTVDEkEQkQLLM
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • JNK1 (human)
Treatment
  • sorbitol
MKK4 (human) IRSTVDEkEQkQLLM K140-ub
MKK4 iso2 (human) IRSTVDEKEQKQLLM K151
MKK4 (mouse) IRSTVDEKEQKQLLM K138
MKK4 (rat) IRSTVDEKEQKQLLM K138
K143-ub
TVDEkEQkQLLMDLD
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • JNK1 (human)
Treatment
  • sorbitol
MKK4 (human) TVDEkEQkQLLMDLD K143-ub
MKK4 iso2 (human) TVDEKEQKQLLMDLD K154
MKK4 (mouse) TVDEKEQKQLLMDLD K141
MKK4 (rat) TVDEKEQKQLLMDLD K141
Y191
SFDKFYKYVYSVLDD
0 1
MKK4 (human) SFDKFYKYVYSVLDD Y191
MKK4 iso2 (human) SFDKFYKYVYSVLDD Y202
MKK4 (mouse) SFDKFYKYVYSVLDD Y189
MKK4 (rat) SFDKFYKyVySVLDD Y189-p
Y193
DKFYKYVYSVLDDVI
0 1
MKK4 (human) DKFYKYVYSVLDDVI Y193
MKK4 iso2 (human) DKFYKYVYSVLDDVI Y204
MKK4 (mouse) DKFYKYVYSVLDDVI Y191
MKK4 (rat) DKFYKyVySVLDDVI Y191-p
K214-ub
KITLATVkALNHLKE
0 1
MKK4 (human) KITLATVkALNHLKE K214-ub
MKK4 iso2 (human) KITLATVKALNHLKE K225
MKK4 (mouse) KITLATVKALNHLkE K212
MKK4 (rat) KITLATVKALNHLkE K212
K220
VkALNHLKENLKIIH
0 2
MKK4 (human) VkALNHLKENLKIIH K220
MKK4 iso2 (human) VKALNHLKENLKIIH K231
MKK4 (mouse) VKALNHLkENLKIIH K218-ac
MKK4 (rat) VKALNHLkENLKIIH K218-ac
K231-ub
KIIHRDIkPSNILLD
0 1
MKK4 (human) KIIHRDIkPSNILLD K231-ub
MKK4 iso2 (human) KIIHRDIKPSNILLD K242
MKK4 (mouse) KIIHRDIKPSNILLD K229
MKK4 (rat) KIIHRDIKPSNILLD K229
S257-p
ISGQLVDsIAKtRDA
Upstream
Downstream
14 61
MKK4 (human)
S257-p
MKK4 (mouse)
S255-p
MKK4 (rat)
S255-p
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • MKK4 (human)
  • MLK3 (human)
Putative in vivo kinases:
  • MLK3 (human)
Regulatory protein:
  • DUSP14 (human)
Treatment
  • anti-CD3
  • bortezomib
  • pneumolysin
  • vanadate
  • vemurafenib
MKK4 (human) ISGQLVDsIAKtRDA S257-p
MKK4 iso2 (human) ISGQLVDSIAKTRDA S268
MKK4 (mouse) ISGQLVDsIAKtRDA S255-p
MKK4 (rat) ISGQLVDSIAKtRDA S255
T261-p
LVDsIAKtRDAGCRP
Upstream
Downstream
25 4
MKK4 (human)
T261-p
MKK4 (mouse)
T259-p
MKK4 (rat)
T259-p
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • transcription, induced
Kinase, in vitro:
  • MKK4 (human)
  • MLK3 (human)
Putative in vivo kinases:
  • ASK1 (human)
  • MLK3 (human)
Putative upstream phosphatases:
  • PPP5C (human)
Regulatory protein:
  • Akt1 (human)
  • DUSP14 (human)
  • JIP3 (human)
  • PRKD1 (human)
Treatment
  • angiopoietin-1
  • anisomycin
  • anti-CD3
  • bortezomib
  • CCT007093
  • CTGF
  • glucose_starvation
  • H2O2
  • hypoxia
  • IL-6
  • ionizing_radiation
  • LY294002
  • neurotensin
  • pneumolysin
  • rottlerin
  • siRNA
  • vanadate
  • wortmannin
MKK4 (human) LVDsIAKtRDAGCRP T261-p
MKK4 iso2 (human) LVDSIAKTRDAGCRP T272
MKK4 (mouse) LVDsIAKtRDAGCRP T259-p
MKK4 (rat) LVDSIAKtRDAGCRP T259-p
T391-p
ILDQMPAtPssPMYV
0 7
MKK4 (human) ILDQMPAtPssPMYV T391-p
MKK4 iso2 (human) ILDQMPATPSSPMYV T402
MKK4 (mouse) ILDQMPAtPssPMyV T389-p
MKK4 (rat) ILDQMPAtPSSPMYV T389-p
S393-p
DQMPAtPssPMYVD_
0 5
MKK4 (human) DQMPAtPssPMYVD_ S393-p
MKK4 iso2 (human) DQMPATPSSPMYVD_ S404
MKK4 (mouse) DQMPAtPssPMyVD_ S391-p
MKK4 (rat) DQMPAtPSSPMYVD_ S391
S394-p
QMPAtPssPMYVD__
0 10
MKK4 (human) QMPAtPssPMYVD__ S394-p
MKK4 iso2 (human) QMPATPSSPMYVD__ S405
MKK4 (mouse) QMPAtPssPMyVD__ S392-p
MKK4 (rat) QMPAtPSSPMYVD__ S392
Y397
AtPssPMYVD_____
0 1
MKK4 (human) AtPssPMYVD_____ Y397
MKK4 iso2 (human) ATPSSPMYVD_____ Y408
MKK4 (mouse) AtPssPMyVD_____ Y395-p
MKK4 (rat) AtPSSPMYVD_____ Y395