Other Species / Isoforms
  ITCH (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2-p
______MsDSGsQLG
0 1
ITCH (human) ______MsDSGsQLG S2-p
ITCH iso2 (human) ______MSDSGSQLG S2
ITCH (mouse) ______MSDSGPQLD S2
ITCH (rat) gap -
S6-p
__MsDSGsQLGsMGS
0 1
ITCH (human) __MsDSGsQLGsMGS S6-p
ITCH iso2 (human) __MSDSGSQLGSMGS S6
ITCH (mouse) __MSDSGPQLDSMGS P6
ITCH (rat) gap -
S10-p
DSGsQLGsMGSLTMK
0 3
ITCH (human) DSGsQLGsMGSLTMK S10-p
ITCH iso2 (human) DSGSQLGSMGSLTMK S10
ITCH (mouse) DSGPQLDSMGSLTMK S10
ITCH (rat) gap -
S18
MGSLTMKSQLQITVI
0 1
ITCH (human) MGSLTMKSQLQITVI S18
ITCH iso2 (human) MGSLTMKSQLQITVI S18
ITCH (mouse) MGSLTMKsQLQITVI S18-p
ITCH (rat) MGSLTMKSQLQITVI S8
S26
QLQITVISAKLKENK
0 1
ITCH (human) QLQITVISAKLKENK S26
ITCH iso2 (human) QLQITVISAKLKENK S26
ITCH (mouse) QLQITVIsAKLKENK S26-p
ITCH (rat) QLQITVISAKLKENK S16
K34-ub
AKLKENKkNWFGPSP
0 4
ITCH (human) AKLKENKkNWFGPSP K34-ub
ITCH iso2 (human) AKLKENKKNWFGPSP K34
ITCH (mouse) AKLKENKKNWFGPSP K34
ITCH (rat) AKLKENKKNWFGPSP K24
K53-m1
TVDGQSKkTEkCNNT
0 1
ITCH (human) TVDGQSKkTEkCNNT K53-m1
ITCH iso2 (human) TVDGQSKKTEKCNNT K53
ITCH (mouse) TVDGQSKKTEKCNNT K53
ITCH (rat) TVDGQSKKTEKCNNT K43
K56-ub
GQSKkTEkCNNTNSP
0 1
ITCH (human) GQSKkTEkCNNTNSP K56-ub
ITCH iso2 (human) GQSKKTEKCNNTNSP K56
ITCH (mouse) GQSKKTEKCNNTNSP K56
ITCH (rat) GQSKKTEKCNNTNSP K46
K64-ub
CNNTNSPkWkQPLTV
0 1
ITCH (human) CNNTNSPkWkQPLTV K64-ub
ITCH iso2 (human) CNNTNSPKWKQPLTV K64
ITCH (mouse) CNNTNSPKWkQPLTV K64
ITCH (rat) CNNTNSPKWKQPLTV K54
K66-ub
NTNSPkWkQPLTVIV
0 6
ITCH (human) NTNSPkWkQPLTVIV K66-ub
ITCH iso2 (human) NTNSPKWKQPLTVIV K66
ITCH (mouse) NTNSPKWkQPLTVIV K66-ub
ITCH (rat) NTNSPKWKQPLTVIV K56
K90-ub
VWSHQTLkSDVLLGT
0 1
ITCH (human) VWSHQTLkSDVLLGT K90-ub
ITCH iso2 (human) VWSHQTLKSDVLLGT K90
ITCH (mouse) VWSHQTLKSDVLLGT K90
ITCH (rat) VWSHQTLKSDVLLGT K80
K107-ub
LDIYETLkSNNMKLE
0 1
ITCH (human) LDIYETLkSNNMKLE K107-ub
ITCH iso2 (human) LDIYETLKSNNMKLE K107
ITCH (mouse) LDIYETLKSNNMKLE K107
ITCH (rat) LDIYETLKSNNMKLE K97
S202
VAGFTGASQNDDGSR
1 0
ITCH (human) VAGFTGASQNDDGSR S202
ITCH iso2 (human) TTCSESAsQNDDGSR S161-p
ITCH (mouse) TSCSESTTQNDDGCR T161
ITCH (rat) TSCSEGATQNDAGCR T151
T214-p
GSRSKDEtRVstNGs
0 1
ITCH (human) GSRSKDEtRVstNGs T214-p
ITCH iso2 (human) GSRSKDETRVSTNGS T173
ITCH (mouse) GCRTRDDTRVStNGs T173
ITCH (rat) GCRPKDETRVSTNGS T163
S217-p
SKDEtRVstNGsDDP
Upstream
0 2
Treatment
  • BI2536
ITCH (human) SKDEtRVstNGsDDP S217-p
ITCH iso2 (human) SKDETRVSTNGSDDP S176
ITCH (mouse) TRDDTRVStNGsEDP S176
ITCH (rat) PKDETRVSTNGSEDP S166
T218-p
KDEtRVstNGsDDPE
0 2
ITCH (human) KDEtRVstNGsDDPE T218-p
ITCH iso2 (human) KDETRVSTNGSDDPE T177
ITCH (mouse) RDDTRVStNGsEDPE T177-p
ITCH (rat) KDETRVSTNGSEDPE T167
S221-p
tRVstNGsDDPEDAG
Upstream
0 5
Treatment
  • AZD1152
  • ZM447439
ITCH (human) tRVstNGsDDPEDAG S221-p
ITCH iso2 (human) TRVSTNGSDDPEDAG S180
ITCH (mouse) TRVStNGsEDPEVAA S180-p
ITCH (rat) TRVSTNGSEDPEVAA S170
R233
DAGAGENRRVsGNNs
0 28
ITCH (human) DAGAGENRRVsGNNs R233
ITCH iso2 (human) DAGAGENRRVSGNNS R192
ITCH (mouse) VAASGENkRANGNNs K192-ub
ITCH (rat) VAASGENkRANGNNS K182-ub
S236-p
AGENRRVsGNNsPSL
0 2
ITCH (human) AGENRRVsGNNsPSL S236-p
ITCH iso2 (human) AGENRRVSGNNSPSL S195
ITCH (mouse) SGENkRANGNNsPSL N195
ITCH (rat) SGENkRANGNNSPSL N185
S240-p
RRVsGNNsPSLsNGG
1 6
ITCH (human) RRVsGNNsPSLsNGG S240-p
ITCH iso2 (human) RRVSGNNSPSLSNGG S199
ITCH (mouse) kRANGNNsPSLSNGG S199-p
ITCH (rat) kRANGNNSPSLSNGG S189
S244-p
GNNsPSLsNGGFKPs
0 1
ITCH (human) GNNsPSLsNGGFKPs S244-p
ITCH iso2 (human) GNNSPSLSNGGFKPS S203
ITCH (mouse) GNNsPSLSNGGFKPS S203
ITCH (rat) GNNSPSLSNGGFKPS S193
S251-p
sNGGFKPsRPPRPsR
0 1
ITCH (human) sNGGFKPsRPPRPsR S251-p
ITCH iso2 (human) SNGGFKPSRPPRPSR S210
ITCH (mouse) SNGGFKPSRPPRPSR S210
ITCH (rat) SNGGFKPSRPPRPSR S200
S257-p
PsRPPRPsRPPPPTP
Upstream
Downstream
1 2
Effects on Modified Protein
  • intracellular localization
  • ubiquitination
Effects on Biological Processes:
  • carcinogenesis, induced
  • signaling pathway regulation
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • EGF
  • erlotinib
  • hydroxyurea
  • ionizing_radiation
  • MK-2206
  • pictilisib
  • serum_starvation
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ITCH (human) PsRPPRPsRPPPPTP S257-p
ITCH iso2 (human) PSRPPRPSRPPPPtP S216
ITCH (mouse) PSRPPRPSRPPPPtP S216
ITCH (rat) PSRPPRPSRPPPPTP S206
T263
PsRPPPPTPRRPASV
4 0
ITCH (human) PsRPPPPTPRRPASV T263
ITCH iso2 (human) PSRPPPPtPRRPASV T222-p
ITCH (mouse) PSRPPPPtPRRPASV T222-p
ITCH (rat) PSRPPPPTPRRPASV T212
S273
RPASVNGSPSATSES
1 0
ITCH (human) RPASVNGSPSATSES S273
ITCH iso2 (human) RPASVNGSPSATSES S232
ITCH (mouse) RPASVNGsPSTNSDS S232-p
ITCH (rat) RPASVNGSPSTNSDS S222
Y343-p
VDQHGRVyyVDHVEk
0 5
ITCH (human) VDQHGRVyyVDHVEk Y343-p
ITCH iso2 (human) VDQHGRVYYVDHVEK Y302
ITCH (mouse) VDQHGRVYYVDHVEk Y304
ITCH (rat) VDQHGRAYYVDHVEK Y294
Y344-p
DQHGRVyyVDHVEkR
0 1
ITCH (human) DQHGRVyyVDHVEkR Y344-p
ITCH iso2 (human) DQHGRVYYVDHVEKR Y303
ITCH (mouse) DQHGRVYYVDHVEkR Y305
ITCH (rat) DQHGRAYYVDHVEKR Y295
K350-ub
yyVDHVEkRTTWDRP
0 5
ITCH (human) yyVDHVEkRTTWDRP K350-ub
ITCH iso2 (human) YYVDHVEKRTTWDRP K309
ITCH (mouse) YYVDHVEkRTTWDRP K311-ub
ITCH (rat) YYVDHVEKRTTRDRP K301
Y375-p
VDNMGRIyyVDHFTR
0 6
ITCH (human) VDNMGRIyyVDHFTR Y375-p
ITCH iso2 (human) VDNMGRIYYVDHFTR Y334
ITCH (mouse) VDNMGRIYYVDHFTR Y336
ITCH (rat) VDNMGRIYYVDHFTR Y326
Y376-p
DNMGRIyyVDHFTRT
0 1
ITCH (human) DNMGRIyyVDHFTRT Y376-p
ITCH iso2 (human) DNMGRIYYVDHFTRT Y335
ITCH (mouse) DNMGRIYYVDHFTRT Y337
ITCH (rat) DNMGRIYYVDHFTRT Y327
T385-p
DHFTRTTtWQRPTLE
Upstream
1 0
Kinase, in vitro:
  • SGK3 (human)
ITCH (human) DHFTRTTtWQRPTLE T385-p
ITCH iso2 (human) DHFTRTTTWQRPTLE T344
ITCH (mouse) DHFTRTTTWQRPTLE T346
ITCH (rat) DHFTRTTTWQRPTLE T336
S393-p
WQRPTLEsVRNyEQW
0 1
ITCH (human) WQRPTLEsVRNyEQW S393-p
ITCH iso2 (human) WQRPTLESVRNYEQW S352
ITCH (mouse) WQRPTLESVRNYEQW S354
ITCH (rat) WQRPTLESVRNYEQW S344
Y397-p
TLEsVRNyEQWQLQR
0 5
ITCH (human) TLEsVRNyEQWQLQR Y397-p
ITCH iso2 (human) TLESVRNYEQWQLQR Y356
ITCH (mouse) TLESVRNYEQWQLQR Y358
ITCH (rat) TLESVRNYEQWQLQR Y348
Y420-p
QFNQRFIyGNQDLFA
Upstream
Downstream
1 100
Effects on Modified Protein
  • molecular association, regulation
Putative in vivo kinases:
  • Fyn (human)
Treatment
  • antibody
ITCH (human) QFNQRFIyGNQDLFA Y420-p
ITCH iso2 (human) QFNQRFIYGNQDLFA Y379
ITCH (mouse) QFNQRFIYGNQDLFA Y381
ITCH (rat) QFNQRFIFGNQDLFA F371
K432-ub
LFATSQSkEFDPLGP
0 99
ITCH (human) LFATSQSkEFDPLGP K432-ub
ITCH iso2 (human) LFATSQSKEFDPLGP K391
ITCH (mouse) LFATSQNkEFDPLGP K393-ub
ITCH (rat) LFATSQNkEFDPLGP K383-ub
K446-ub
PLPPGWEkRTDsNGR
0 49
ITCH (human) PLPPGWEkRTDsNGR K446-ub
ITCH iso2 (human) PLPPGWEKRTDSNGR K405
ITCH (mouse) PLPPGWEkRTDsNGR K407-ub
ITCH (rat) PLPPGWEkRTDSNGR K397-ub
S450-p
GWEkRTDsNGRVYFV
Upstream
3 0
Kinase, in vitro:
  • SGK3 (human)
ITCH (human) GWEkRTDsNGRVYFV S450-p
ITCH iso2 (human) GWEKRTDSNGRVYFV S409
ITCH (mouse) GWEkRTDsNGRVYFV S411-p
ITCH (rat) GWEkRTDSNGRVYFV S401
T464
VNHNTRITQWEDPRS
2 0
ITCH (human) VNHNTRITQWEDPRS T464
ITCH iso2 (human) VNHNTRITQWEDPRS T423
ITCH (mouse) VNHNTRItQWEDPRS T425-p
ITCH (rat) VNHNTRITQWEDPRS T415
K478-ub
SQGQLNEkPLPEGWE
0 40
ITCH (human) SQGQLNEkPLPEGWE K478-ub
ITCH iso2 (human) SQGQLNEKPLPEGWE K437
ITCH (mouse) SQGQLNEkPLPEGWE K439-ub
ITCH (rat) SQGQLNEkPLPEGWE K429-ub
Y495-p
FTVDGIPyFVDHNRR
0 1
ITCH (human) FTVDGIPyFVDHNRR Y495-p
ITCH iso2 (human) FTVDGIPYFVDHNRR Y454
ITCH (mouse) FTVDGIPYFVDHNRR Y456
ITCH (rat) FTVDGIPYFVDHNRR Y446
T503-p
FVDHNRRtttyIDPR
0 1
ITCH (human) FVDHNRRtttyIDPR T503-p
ITCH iso2 (human) FVDHNRRTTTYIDPR T462
ITCH (mouse) FVDHNRRATTYIDPR A464
ITCH (rat) FVDHNRRATTYIDPR A454
T504-p
VDHNRRtttyIDPRT
0 1
ITCH (human) VDHNRRtttyIDPRT T504-p
ITCH iso2 (human) VDHNRRTTTYIDPRT T463
ITCH (mouse) VDHNRRATTYIDPRT T465
ITCH (rat) VDHNRRATTYIDPRT T455
T505-p
DHNRRtttyIDPRTG
0 1
ITCH (human) DHNRRtttyIDPRTG T505-p
ITCH iso2 (human) DHNRRTTTYIDPRTG T464
ITCH (mouse) DHNRRATTYIDPRTG T466
ITCH (rat) DHNRRATTYIDPRTG T456
Y506-p
HNRRtttyIDPRTGk
0 1
ITCH (human) HNRRtttyIDPRTGk Y506-p
ITCH iso2 (human) HNRRTTTYIDPRTGK Y465
ITCH (mouse) HNRRATTYIDPRTGk Y467
ITCH (rat) HNRRATTYIDPRTGK Y457
K513-ub
yIDPRTGkSALDNGP
0 6
ITCH (human) yIDPRTGkSALDNGP K513-ub
ITCH iso2 (human) YIDPRTGKSALDNGP K472
ITCH (mouse) YIDPRTGksALDNGP K474-ub
ITCH (rat) YIDPRTGKSALDNGP K464
S514
IDPRTGkSALDNGPQ
0 1
ITCH (human) IDPRTGkSALDNGPQ S514
ITCH iso2 (human) IDPRTGKSALDNGPQ S473
ITCH (mouse) IDPRTGksALDNGPQ S475-p
ITCH (rat) IDPRTGKSALDNGPQ S465
Y589-p
PGEEGLDyGGVAREW
0 13
ITCH (human) PGEEGLDyGGVAREW Y589-p
ITCH iso2 (human) PGEEGLDYGGVAREW Y548
ITCH (mouse) PGEEGLDYGGVAREW Y550
ITCH (rat) PGEEGLDyGGVAREW Y540-p
K670-ub
FYKRILNkPVGLKDL
0 1
ITCH (human) FYKRILNkPVGLKDL K670-ub
ITCH iso2 (human) FYKRILNKPVGLKDL K629
ITCH (mouse) FYKRILNKPVGLKDL K631
ITCH (rat) FYKRILNKPVGLKDL K621
S687-p
IDPEFYNsLIWVKEN
Downstream
1 0
Effects on Modified Protein
  • molecular association, regulation
ITCH (human) IDPEFYNsLIWVKEN S687-p
ITCH iso2 (human) IDPEFYNSLIWVKEN S646
ITCH (mouse) IDPEFYNSLIWVKEN S648
ITCH (rat) IDPEFYNSLIWVKEN S638
K861-ub
FCIEKVGkENWLPRS
0 4
ITCH (human) FCIEKVGkENWLPRS K861-ub
ITCH iso2 (human) FCIEKVGKENWLPRS K820
ITCH (mouse) FCIEKVGKENWLPRS K822
ITCH (rat) FCIEKVGKENWLPRS K812