Other Species / Isoforms
  PDK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
R3
_____MARTTSQLyD
0 1
PDK1 (human) _____MARTTSQLyD R3
PDK1 iso2 (human) gap -
PDK1 iso4 (human) _____MARTTSQLYD R3
PDK1 iso5 (human) _____MARTTSQLYD R3
PDK1 (mouse) _____MArTTSQLYD R3-m1
PDK1 (rat) _____MARTTSQLyD R3
Y9-p
ARTTSQLyDAVPIQS
Upstream
Downstream
5 7
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein degradation
Effects on Biological Processes:
  • transcription, altered
Putative in vivo kinases:
  • Ret (human)
Regulatory protein:
  • HSP90A (human)
Treatment
  • insulin
  • LY294002
  • N-alpha-tosyl-L-phenylalanyl_chloromethyl_ketone
  • PP1
  • rapamycin
  • vanadate
  • wortmannin
PDK1 (human) ARTTSQLyDAVPIQS Y9-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) ARTTSQLYDAVPIQS Y9
PDK1 iso5 (human) ARTTSQLYDAVPIQS Y9
PDK1 (mouse) ArTTSQLYDAVPIQS Y9
PDK1 (rat) ARTTSQLyDAVPIQS Y9-p
S22-p
QSSVVLCsCPsPSMV
0 1
PDK1 (human) QSSVVLCsCPsPSMV S22-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) QSSVVLCSCPSPSMV S22
PDK1 iso5 (human) QSSVVLCSCPSPSMV S22
PDK1 (mouse) QSSVVLCSCPsPSMV S22
PDK1 (rat) QSSVVLCSCPSPSMV S22
S25-p
VVLCsCPsPSMVRTQ
Upstream
1 5
Kinase, in vitro:
  • PDK1 (human)
Putative in vivo kinases:
  • PDK1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
PDK1 (human) VVLCsCPsPSMVRTQ S25-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) VVLCSCPSPSMVRTQ S25
PDK1 iso5 (human) VVLCSCPSPSMVRTQ S25
PDK1 (mouse) VVLCSCPsPSMVRSQ S25-p
PDK1 (rat) VVLCSCPSPSMVRSQ S25
T33-p
PSMVRTQtESstPPG
0 2
PDK1 (human) PSMVRTQtESstPPG T33-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) PSMVRTQTESStPPG T33
PDK1 iso5 (human) PSMVRTQTESSTPPG T33
PDK1 (mouse) PSMVRSQTEPGSsPG T33
PDK1 (rat) PSMVRSQTEPSSSPG T33
S36-p
VRTQtESstPPGIPG
0 1
PDK1 (human) VRTQtESstPPGIPG S36-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) VRTQTESStPPGIPG S36
PDK1 iso5 (human) VRTQTESSTPPGIPG S36
PDK1 (mouse) VRSQTEPGSsPGIPS G36
PDK1 (rat) VRSQTEPSSSPGIPS S36
T37-p
RTQtESstPPGIPGG
0 22
PDK1 (human) RTQtESstPPGIPGG T37-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) RTQTESStPPGIPGG T37-p
PDK1 iso5 (human) RTQTESSTPPGIPGG T37
PDK1 (mouse) RSQTEPGSsPGIPSG S37
PDK1 (rat) RSQTEPSSSPGIPSG S37
P38
TQtESstPPGIPGGs
0 2
PDK1 (human) TQtESstPPGIPGGs P38
PDK1 iso2 (human) gap -
PDK1 iso4 (human) TQTESStPPGIPGGS P38
PDK1 iso5 (human) TQTESSTPPGIPGGS P38
PDK1 (mouse) SQTEPGSsPGIPSGV S38-p
PDK1 (rat) SQTEPSSSPGIPSGV S38
S45-p
PPGIPGGsRQGPAMD
0 2
PDK1 (human) PPGIPGGsRQGPAMD S45-p
PDK1 iso2 (human) gap -
PDK1 iso4 (human) PPGIPGGSRQGPAMD S45
PDK1 iso5 (human) PPGIPGGSRQGPAMD S45
PDK1 (mouse) PGIPSGVSRQGsTMD S46
PDK1 (rat) PGIPSGVSRQGSTMD S46
P49
PGGsRQGPAMDGTAA
0 1
PDK1 (human) PGGsRQGPAMDGTAA P49
PDK1 iso2 (human) gap -
PDK1 iso4 (human) PGGSRQGPAMDGTAA P49
PDK1 iso5 (human) PGGSRQGPAMDGTAA P49
PDK1 (mouse) SGVSRQGsTMDGttA S50-p
PDK1 (rat) SGVSRQGSTMDGTTA S50
T54
QGPAMDGTAAEPRPG
0 1
PDK1 (human) QGPAMDGTAAEPRPG T54
PDK1 iso2 (human) ____MDGTAAEPRPG T4
PDK1 iso4 (human) QGPAMDGTAAEPRPG T54
PDK1 iso5 (human) QGPAMDGTAAEPRPG T54
PDK1 (mouse) QGsTMDGttAEARPS T55-p
PDK1 (rat) QGSTMDGTTAEARPS T55
A55
GPAMDGTAAEPRPGA
0 1
PDK1 (human) GPAMDGTAAEPRPGA A55
PDK1 iso2 (human) ___MDGTAAEPRPGA A5
PDK1 iso4 (human) GPAMDGTAAEPRPGA A55
PDK1 iso5 (human) GPAMDGTAAEPRPGA A55
PDK1 (mouse) GsTMDGttAEARPSt T56-p
PDK1 (rat) GSTMDGTTAEARPST T56
A62
AAEPRPGAGsLQHAQ
0 1
PDK1 (human) AAEPRPGAGsLQHAQ A62
PDK1 iso2 (human) AAEPRPGAGSLQHAQ A12
PDK1 iso4 (human) AAEPRPGAGSLQHAQ A62
PDK1 iso5 (human) AAEPRPGAGSLQHAQ A62
PDK1 (mouse) tAEARPStNPLQQHP T63-p
PDK1 (rat) TAEARPSTNPLQQHP T63
S64-p
EPRPGAGsLQHAQPP
Upstream
Downstream
1 2
Effects on Modified Protein
  • protein stabilization
Putative in vivo kinases:
  • PKCT (human)
PDK1 (human) EPRPGAGsLQHAQPP S64-p
PDK1 iso2 (human) EPRPGAGSLQHAQPP S14
PDK1 iso4 (human) EPRPGAGSLQHAQPP S64
PDK1 iso5 (human) EPRPGAGSLQHAQPP S64
PDK1 (mouse) EARPStNPLQQHPAQ P65
PDK1 (rat) EARPSTNPLQQHPAQ P65
K83-ub
KKRPEDFkFGKILGE
0 1
PDK1 (human) KKRPEDFkFGKILGE K83-ub
PDK1 iso2 (human) KKRPEDFKFGKILGE K33
PDK1 iso4 (human) KKRPEDFKFGKILGE K83
PDK1 iso5 (human) KKRPEDFKFGKILGE K83
PDK1 (mouse) KKRPEDFKFGKILGE K86
PDK1 (rat) KKRPEDFKFGKILGE K86
S92-p
GKILGEGsFSTVVLA
0 1
PDK1 (human) GKILGEGsFSTVVLA S92-p
PDK1 iso2 (human) GKILGEGSFSTVVLA S42
PDK1 iso4 (human) GKILGEGSFSTVVLA S92
PDK1 iso5 (human) GKILGEGSFSTVVLA S92
PDK1 (mouse) GKILGEGSFStVVLA S95
PDK1 (rat) GKILGEGSFSTVVLA S95
T95
LGEGsFSTVVLAREL
0 1
PDK1 (human) LGEGsFSTVVLAREL T95
PDK1 iso2 (human) LGEGSFSTVVLAREL T45
PDK1 iso4 (human) LGEGSFSTVVLAREL T95
PDK1 iso5 (human) LGEGSFSTVVLAREL T95
PDK1 (mouse) LGEGSFStVVLAREL T98-p
PDK1 (rat) LGEGSFSTVVLAREL T98
K111-ub
TSREYAIkILEKRHI
0 1
PDK1 (human) TSREYAIkILEKRHI K111-ub
PDK1 iso2 (human) TSREYAIKILEKRHI K61
PDK1 iso4 (human) under review -
PDK1 iso5 (human) TSREYAIKILEKRHI K111
PDK1 (mouse) TSREYAIKILEKRHI K114
PDK1 (rat) TSREYAIKILEKRHI K114
K123-ub
RHIIKENkVPYVTRE
0 3
PDK1 (human) RHIIKENkVPYVTRE K123-ub
PDK1 iso2 (human) RHIIKENKVPYVTRE K73
PDK1 iso4 (human) gap -
PDK1 iso5 (human) RHIIKENKVPYVTRE K123
PDK1 (mouse) RHIIKENkVPYVTRE K126-ub
PDK1 (rat) RHIIKENKVPYVTRE K126
T148-p
FFVKLYFtFQDDEKL
0 1
PDK1 (human) FFVKLYFtFQDDEKL T148-p
PDK1 iso2 (human) FFVKLYFTFQDDEKL T98
PDK1 iso4 (human) gap -
PDK1 iso5 (human) FFVKLYFTFQDDEKL T148
PDK1 (mouse) FFVKLYFTFQDDEKL T151
PDK1 (rat) FFVKLYFTFQDDEKL T151
Y156-p
FQDDEKLyFGLsyAK
0 1
PDK1 (human) FQDDEKLyFGLsyAK Y156-p
PDK1 iso2 (human) FQDDEKLYFGLSYAK Y106
PDK1 iso4 (human) gap -
PDK1 iso5 (human) FQDDEKLYFGLSYAK Y156
PDK1 (mouse) FQDDEKLYFGLsYAK Y159
PDK1 (rat) FQDDEKLYFGLSYAK Y159
S160-p
EKLyFGLsyAKNGEL
1 1
PDK1 (human) EKLyFGLsyAKNGEL S160-p
PDK1 iso2 (human) EKLYFGLSYAKNGEL S110
PDK1 iso4 (human) gap -
PDK1 iso5 (human) EKLYFGLSYAKNGEL S160
PDK1 (mouse) EKLYFGLsYAKNGEL S163-p
PDK1 (rat) EKLYFGLSYAKNGEL S163
Y161-p
KLyFGLsyAKNGELL
0 1
PDK1 (human) KLyFGLsyAKNGELL Y161-p
PDK1 iso2 (human) KLYFGLSYAKNGELL Y111
PDK1 iso4 (human) gap -
PDK1 iso5 (human) KLYFGLSYAKNGELL Y161
PDK1 (mouse) KLYFGLsYAKNGELL Y164
PDK1 (rat) KLYFGLSYAKNGELL Y164
S176-p
KYIRKIGsFDEtCTR
0 1
PDK1 (human) KYIRKIGsFDEtCTR S176-p
PDK1 iso2 (human) KYIRKIGSFDETCTR S126
PDK1 iso4 (human) gap -
PDK1 iso5 (human) KYIRKIGSFDETCTR S176
PDK1 (mouse) KYIRKIGSFDETCTR S179
PDK1 (rat) KYIRKIGSFDETCTR S179
T180-p
KIGsFDEtCTRFYTA
0 1
PDK1 (human) KIGsFDEtCTRFYTA T180-p
PDK1 iso2 (human) KIGSFDETCTRFYTA T130
PDK1 iso4 (human) gap -
PDK1 iso5 (human) KIGSFDETCTRFYTA T180
PDK1 (mouse) KIGSFDETCTRFYTA T183
PDK1 (rat) KIGSFDETCTRFYTA T183
S231-p
FGTAKVLsPEskQAR
0 2
PDK1 (human) FGTAKVLsPEskQAR S231-p
PDK1 iso2 (human) FGTAKVLSPESKQAR S181
PDK1 iso4 (human) gap -
PDK1 iso5 (human) FGTAKVLSPESKQAR S231
PDK1 (mouse) FGTAKVLsPESKQAR S234-p
PDK1 (rat) FGTAKVLSPDSKQAR S234
S234-p
AKVLsPEskQARANs
0 1
PDK1 (human) AKVLsPEskQARANs S234-p
PDK1 iso2 (human) AKVLSPESKQARANS S184
PDK1 iso4 (human) gap -
PDK1 iso5 (human) AKVLSPESKQARANS S234
PDK1 (mouse) AKVLsPESKQARANs S237
PDK1 (rat) AKVLSPDSKQARANs S237
K235-ub
KVLsPEskQARANsF
0 2
PDK1 (human) KVLsPEskQARANsF K235-ub
PDK1 iso2 (human) KVLSPESKQARANSF K185
PDK1 iso4 (human) under review -
PDK1 iso5 (human) KVLSPESKQARANSF K235
PDK1 (mouse) KVLsPESKQARANsF K238
PDK1 (rat) KVLSPDSKQARANsF K238
S241-p
skQARANsFVGtAQy
Upstream
Downstream
55 349
PDK1 (human)
S241-p
PDK1 (mouse)
S244-p
PDK1 (rat)
S244-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell growth, induced
Kinase, in vitro:
  • PDK1 (human)
Putative in vivo kinases:
  • PDK1 (human)
  • PKCT (human)
Regulatory protein:
  • AMIGO2 (human)
  • DYRK2 (human)
  • HRas (human)
  • KRas (human)
  • LKB1 (human)
  • MELK (mouse)
  • PDK1 (human)
Treatment
  • 2-deoxyglucose
  • alpha2-macroglobulin
  • BX795
  • calyculin_A
  • ceramide
  • estrogen_deprivation
  • FTI277
  • GSK2334470
  • IGF-1
  • insulin
  • ionizing_radiation
  • IP(6)
  • IQA
  • ischemia
  • KP-372-1
  • lapatinib
  • LY294002
  • methyl-beta-cyclodextrin
  • miRNA
  • naltrindole
  • PDK1_inhibitor_1
  • PDK1_inhibitor_2
  • PDK1_inhibitor_3
  • QLT0254
  • sardomozide
  • selenite
  • siRNA
  • TBB
  • thrombin
  • VEGF
PDK1 (human) skQARANsFVGtAQy S241-p
PDK1 iso2 (human) SKQARANSFVGTAQY S191
PDK1 iso4 (human) EYATRANsFVGTAQY S114-p
PDK1 iso5 (human) SKQARANSFVGTAQY S241
PDK1 (mouse) SKQARANsFVGtAQy S244-p
PDK1 (rat) SKQARANsFVGTAQY S244-p
T245-p
RANsFVGtAQyVsPE
0 35
PDK1 (human) RANsFVGtAQyVsPE T245-p
PDK1 iso2 (human) RANSFVGTAQYVSPE T195
PDK1 iso4 (human) RANsFVGTAQYVSPE T118
PDK1 iso5 (human) RANSFVGTAQYVSPE T245
PDK1 (mouse) RANsFVGtAQyVSPE T248-p
PDK1 (rat) RANsFVGTAQYVSPE T248
Y248-p
sFVGtAQyVsPELLt
0 17
PDK1 (human) sFVGtAQyVsPELLt Y248-p
PDK1 iso2 (human) SFVGTAQYVSPELLT Y198
PDK1 iso4 (human) sFVGTAQYVSPELLT Y121
PDK1 iso5 (human) SFVGTAQYVSPELLT Y248
PDK1 (mouse) sFVGtAQyVSPELLT Y251-p
PDK1 (rat) sFVGTAQYVSPELLT Y251
S250-p
VGtAQyVsPELLtEk
0 1
PDK1 (human) VGtAQyVsPELLtEk S250-p
PDK1 iso2 (human) VGTAQYVSPELLTEK S200
PDK1 iso4 (human) VGTAQYVSPELLTEK S123
PDK1 iso5 (human) VGTAQYVSPELLTEK S250
PDK1 (mouse) VGtAQyVSPELLTEk S253
PDK1 (rat) VGTAQYVSPELLTEK S253
T255-p
yVsPELLtEkSACKS
0 1
PDK1 (human) yVsPELLtEkSACKS T255-p
PDK1 iso2 (human) YVSPELLTEKSACKS T205
PDK1 iso4 (human) YVSPELLTEKSACKS T128
PDK1 iso5 (human) YVSPELLTEKSACKS T255
PDK1 (mouse) yVSPELLTEkSACKS T258
PDK1 (rat) YVSPELLTEKSACKS T258
K257-ub
sPELLtEkSACKSSD
0 3
PDK1 (human) sPELLtEkSACKSSD K257-ub
PDK1 iso2 (human) SPELLTEKSACKSSD K207
PDK1 iso4 (human) SPELLTEKSACKSSD K130
PDK1 iso5 (human) SPELLTEKSACKSSD K257
PDK1 (mouse) SPELLTEkSACKSSD K260-ub
PDK1 (rat) SPELLTEKSACKSSD K260
Y288-p
PFRAGNEyLIFQKII
0 5
PDK1 (human) PFRAGNEyLIFQKII Y288-p
PDK1 iso2 (human) PFRAGNEYLIFQKII Y238
PDK1 iso4 (human) PFRAGNEYLIFQKII Y161
PDK1 iso5 (human) PFRAGNEYLIFQKII Y288
PDK1 (mouse) PFRAGNEYLIFQKII Y291
PDK1 (rat) PFRAGNEYLIFQKII Y291
K296
LIFQKIIKLEYDFPE
0 1
PDK1 (human) LIFQKIIKLEYDFPE K296
PDK1 iso2 (human) LIFQKIIKLEYDFPE K246
PDK1 iso4 (human) LIFQKIIKLEYDFPE K169
PDK1 iso5 (human) LIFQKIIKLEYDFPE K296
PDK1 (mouse) LIFQKIIkLEYHFPE K299-ub
PDK1 (rat) LIFQKIIKLEYDFPE K299
K304-ac
LEYDFPEkFFPKARD
0 21
PDK1 (human) LEYDFPEkFFPKARD K304-ac
PDK1 iso2 (human) LEYDFPEKFFPKARD K254
PDK1 iso4 (human) LEYDFPEKFFPKARD K177
PDK1 iso5 (human) LEYDFPEKFFPKARD K304
PDK1 (mouse) LEYHFPEkFFPKARD K307-ac
PDK1 (rat) LEYDFPEkFFPKARD K307-ac
K304-ub
LEYDFPEkFFPKARD
0 2
PDK1 (human) LEYDFPEkFFPKARD K304-ub
PDK1 iso2 (human) LEYDFPEKFFPKARD K254
PDK1 iso4 (human) LEYDFPEKFFPKARD K177
PDK1 iso5 (human) LEYDFPEKFFPKARD K304
PDK1 (mouse) LEYHFPEKFFPKARD K307
PDK1 (rat) LEYDFPEKFFPKARD K307
K315-ub
KARDLVEkLLVLDAT
0 1
PDK1 (human) KARDLVEkLLVLDAT K315-ub
PDK1 iso2 (human) KARDLVEKLLVLDAT K265
PDK1 iso4 (human) KARDLVEKLLVLDAT K188
PDK1 iso5 (human) KARDLVEKLLVLDAT K315
PDK1 (mouse) KARDLVEKLLVLDAT K318
PDK1 (rat) KARDLVEKLLVLDAT K318
K323-ub
LLVLDATkRLGCEEM
0 2
PDK1 (human) LLVLDATkRLGCEEM K323-ub
PDK1 iso2 (human) LLVLDATKRLGCEEM K273
PDK1 iso4 (human) LLVLDATKRLGCEEM K196
PDK1 iso5 (human) LLVLDATKRLGCEEM K323
PDK1 (mouse) LLVLDATKRLGCEEM K326
PDK1 (rat) LLVLDATKRLGCEEM K326
K337-ub
MEGYGPLkAHPFFES
0 1
PDK1 (human) MEGYGPLkAHPFFES K337-ub
PDK1 iso2 (human) MEGYGPLKAHPFFES K287
PDK1 iso4 (human) MEGYGPLKAHPFFES K210
PDK1 iso5 (human) MEGYGPLKAHPFFES K337
PDK1 (mouse) MEGYGPLKAHPFFET K340
PDK1 (rat) MEGYGPLKAHPFFES K340
T354-p
WENLHQQtPPKLTAY
Upstream
Downstream
3 0
Effects on Modified Protein
  • enzymatic activity, inhibited
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, altered
  • cell growth, inhibited
  • signaling pathway regulation
Kinase, in vitro:
  • CDK1 (human)
  • MELK (mouse)
PDK1 (human) WENLHQQtPPKLTAY T354-p
PDK1 iso2 (human) WENLHQQTPPKLTAY T304
PDK1 iso4 (human) WENLHQQTPPKLTAY T227
PDK1 iso5 (human) WENLHQQTPPKLTAY T354
PDK1 (mouse) WENLHQQTPPKLTAY T357
PDK1 (rat) WENLHQQTPPKLTAY T357
S366-p
TAYLPAMsEDDEDCy
0 1
PDK1 (human) TAYLPAMsEDDEDCy S366-p
PDK1 iso2 (human) TAYLPAMSEDDEDCY S316
PDK1 iso4 (human) TAYLPAMSEDDEDCY S239
PDK1 iso5 (human) TAYLPAMSEDDEDCY S366
PDK1 (mouse) TAYLPAMSEDDEDCY S369
PDK1 (rat) TAYLPAMSEDDEDCy S369
Y373-p
sEDDEDCyGNyDNLL
Upstream
Downstream
9 1
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, altered
Kinase, in vitro:
  • IGF1R (human)
  • Src (human)
Putative in vivo kinases:
  • IGF1R (human)
  • Src (human)
Regulatory protein:
  • HRas (human)
  • HSP90A (human)
  • KRas (human)
Treatment
  • FTI277
  • IGF-1
  • insulin
  • ionizing_radiation
  • PP2
  • vanadate
PDK1 (human) sEDDEDCyGNyDNLL Y373-p
PDK1 iso2 (human) SEDDEDCYGNYDNLL Y323
PDK1 iso4 (human) SEDDEDCYGNYDNLL Y246
PDK1 iso5 (human) SEDDEDCYGNYDNLL Y373
PDK1 (mouse) SEDDEDCYGNYDNLL Y376
PDK1 (rat) SEDDEDCyGNyDNLL Y376-p
Y376-p
DEDCyGNyDNLLSQF
Upstream
Downstream
8 1
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, altered
Kinase, in vitro:
  • IGF1R (human)
  • Src (human)
Putative in vivo kinases:
  • IGF1R (human)
  • Src (human)
Regulatory protein:
  • HRas (human)
  • HSP90A (human)
  • KRas (human)
Treatment
  • FTI277
  • IGF-1
  • insulin
  • ionizing_radiation
  • PP2
  • vanadate
PDK1 (human) DEDCyGNyDNLLSQF Y376-p
PDK1 iso2 (human) DEDCYGNYDNLLSQF Y326
PDK1 iso4 (human) DEDCYGNYDNLLSQF Y249
PDK1 iso5 (human) DEDCYGNYDNLLSQF Y376
PDK1 (mouse) DEDCYGNYDNLLSQF Y379
PDK1 (rat) DEDCyGNyDNLLSQF Y379-p
S393-p
MQVSSSSssHsLsAS
Upstream
2 1
Kinase, in vitro:
  • PDK1 (human)
Putative in vivo kinases:
  • PDK1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • UCN-01
PDK1 (human) MQVSSSSssHsLsAS S393-p
PDK1 iso2 (human) MQVSSSSSSHSLSAS S343
PDK1 iso4 (human) MQVSSSSSSHSLSAS S266
PDK1 iso5 (human) MQVSSSSSSHSLSAS S393
PDK1 (mouse) MQVSSSSSSHsLSTV S396
PDK1 (rat) MQVSSSSSSHSLSAV S396
S394-p
QVSSSSssHsLsASD
Upstream
Downstream
2 0
Effects on Biological Processes:
  • apoptosis, altered
  • cell growth, altered
Kinase, in vitro:
  • ASK1 (human)
PDK1 (human) QVSSSSssHsLsASD S394-p
PDK1 iso2 (human) QVSSSSSSHSLSASD S344
PDK1 iso4 (human) QVSSSSSSHSLSASD S267
PDK1 iso5 (human) QVSSSSSSHSLSASD S394
PDK1 (mouse) QVSSSSSSHsLSTVE S397
PDK1 (rat) QVSSSSSSHSLSAVD S397
S396-p
SSSSssHsLsASDTG
Upstream
Downstream
4 1
Effects on Modified Protein
  • intracellular localization
Effects on Biological Processes:
  • transcription, altered
Kinase, in vitro:
  • PDK1 (human)
Putative in vivo kinases:
  • PDK1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • IGF-1
  • PDGF
  • vanadate
PDK1 (human) SSSSssHsLsASDTG S396-p
PDK1 iso2 (human) SSSSSSHSLSASDTG S346
PDK1 iso4 (human) SSSSSSHSLSASDTG S269
PDK1 iso5 (human) SSSSSSHSLSASDTG S396
PDK1 (mouse) SSSSSSHsLSTVETS S399-p
PDK1 (rat) SSSSSSHSLSAVDAS S399
S398-p
SSssHsLsASDTGLP
Upstream
Downstream
2 0
Effects on Biological Processes:
  • apoptosis, altered
  • cell growth, altered
Kinase, in vitro:
  • ASK1 (human)
PDK1 (human) SSssHsLsASDTGLP S398-p
PDK1 iso2 (human) SSSSHSLSASDTGLP S348
PDK1 iso4 (human) SSSSHSLSASDTGLP S271
PDK1 iso5 (human) SSSSHSLSASDTGLP S398
PDK1 (mouse) SSSSHsLSTVETSLP S401
PDK1 (rat) SSSSHSLSAVDASLP S401
S410-p
GLPQRSGsNIEQYIH
Upstream
1 1
Kinase, in vitro:
  • PDK1 (human)
Putative in vivo kinases:
  • PDK1 (human)
Putative upstream phosphatases:
  • PPP2CA (human)
Treatment
  • PDK1_inhibitor_1
  • PDK1_inhibitor_2
  • PDK1_inhibitor_3
PDK1 (human) GLPQRSGsNIEQYIH S410-p
PDK1 iso2 (human) GLPQRSGSNIEQYIH S360
PDK1 iso4 (human) GLPQRSGSNIEQYIH S283
PDK1 iso5 (human) GLPQRSGSNIEQYIH S410
PDK1 (mouse) SLPQRSGSNIEQYIH S413
PDK1 (rat) SLPQRSGSNIEQYIH S413
K441-ub
EKRLLLEkQAGGNPW
0 12
PDK1 (human) EKRLLLEkQAGGNPW K441-ub
PDK1 iso2 (human) EKRLLLEKQAGGNPW K391
PDK1 iso4 (human) EKRLLLEkQAGGNPW K314-ub
PDK1 iso5 (human) EKRLLLEKQAGGNPC K441
PDK1 (mouse) EKRLLLEKQAGGNPW K444
PDK1 (rat) EKRLLLEKQAGGNPW K444
Y485-p
LTEGPHLyyVDPVNK
0 1
PDK1 (human) LTEGPHLyyVDPVNK Y485-p
PDK1 iso2 (human) LTEGPHLYYVDPVNK Y435
PDK1 iso4 (human) LTEGPHLYYVDPVNK Y358
PDK1 iso5 (human) gap -
PDK1 (mouse) LTEGPHLYYVDPVNK Y488
PDK1 (rat) LTEGPHLYYVDPVNK Y488
Y486-p
TEGPHLyyVDPVNKV
0 1
PDK1 (human) TEGPHLyyVDPVNKV Y486-p
PDK1 iso2 (human) TEGPHLYYVDPVNKV Y436
PDK1 iso4 (human) TEGPHLYYVDPVNKV Y359
PDK1 iso5 (human) gap -
PDK1 (mouse) TEGPHLYYVDPVNKV Y489
PDK1 (rat) TEGPHLYYVDPVNKV Y489
K495-ub
DPVNKVLkGEIPWsQ
0 1
PDK1 (human) DPVNKVLkGEIPWsQ K495-ub
PDK1 iso2 (human) DPVNKVLKGEIPWSQ K445
PDK1 iso4 (human) DPVNKVLKGEIPWSQ K368
PDK1 iso5 (human) under review -
PDK1 (mouse) DPVNKVLKGEIPWsQ K498
PDK1 (rat) DPVNKVLKGEIPWSQ K498
S501-p
LkGEIPWsQELRPEA
1 1
PDK1 (human) LkGEIPWsQELRPEA S501-p
PDK1 iso2 (human) LKGEIPWSQELRPEA S451
PDK1 iso4 (human) LKGEIPWSQELRPEA S374
PDK1 iso5 (human) gap -
PDK1 (mouse) LKGEIPWsQELRPEA S504-p
PDK1 (rat) LKGEIPWSQELRPEA S504
K509-ub
QELRPEAkNFKtFFV
0 1
PDK1 (human) QELRPEAkNFKtFFV K509-ub
PDK1 iso2 (human) QELRPEAKNFKTFFV K459
PDK1 iso4 (human) QELRPEAKNFKTFFV K382
PDK1 iso5 (human) under review -
PDK1 (mouse) QELRPEAKNFKtFFV K512
PDK1 (rat) QELRPEAKNFKTFFV K512
T513-p
PEAkNFKtFFVHTPN
Upstream
Downstream
5 4
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • PDK1 (human)
Treatment
  • PDK1_inhibitor_1
  • PDK1_inhibitor_2
  • PDK1_inhibitor_3
PDK1 (human) PEAkNFKtFFVHTPN T513-p
PDK1 iso2 (human) PEAKNFKTFFVHTPN T463
PDK1 iso4 (human) PEAKNFKTFFVHTPN T386
PDK1 iso5 (human) gap -
PDK1 (mouse) PEAKNFKtFFVHTPN T516-p
PDK1 (rat) PEAKNFKTFFVHTPN T516
S529
TYYLMDPSGNAHkWC
1 0
PDK1 (human) TYYLMDPSGNAHkWC S529
PDK1 iso2 (human) TYYLMDPSGNAHKWC S479
PDK1 iso4 (human) TYYLMDPSGNAHkWC S402
PDK1 iso5 (human) gap -
PDK1 (mouse) TYYLMDPsGNAHKWC S532-p
PDK1 (rat) TYYLMDPSGNAHKWC S532
K534-ac
DPSGNAHkWCRKIQE
0 1
PDK1 (human) DPSGNAHkWCRKIQE K534-ac
PDK1 iso2 (human) DPSGNAHKWCRKIQE K484
PDK1 iso4 (human) DPSGNAHkWCRKIQE K407-ac
PDK1 iso5 (human) gap -
PDK1 (mouse) DPsGNAHKWCRKIQE K537
PDK1 (rat) DPSGNAHKWCRKIQE K537