Other Species / Isoforms
  PAK4 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
K31-ub
GFDQHEQkFtGLPRQ
0 1
PAK4 (human) GFDQHEQkFtGLPRQ K31-ub
PAK4 iso2 (human) GFDQHEQKFTGLPRQ K31
PAK4 (mouse) GFDQHEQKFtGLPRQ K31
PAK4 (rat) GFDQHEQKFTGLPRQ K31
T33-p
DQHEQkFtGLPRQWQ
0 1
PAK4 (human) DQHEQkFtGLPRQWQ T33-p
PAK4 iso2 (human) DQHEQKFTGLPRQWQ T33
PAK4 (mouse) DQHEQKFtGLPRQWQ T33-p
PAK4 (rat) DQHEQKFTGLPRQWQ T33
S41-p
GLPRQWQsLIEESAR
Upstream
0 11
Treatment
  • nocodazole
  • thymidine
PAK4 (human) GLPRQWQsLIEESAR S41-p
PAK4 iso2 (human) GLPRQWQSLIEESAR S41
PAK4 (mouse) GLPRQWQsLIEESAR S41-p
PAK4 (rat) GLPRQWQSLIEESAR S41
K51
EESARRPKPLVDPAC
0 1
PAK4 (human) EESARRPKPLVDPAC K51
PAK4 iso2 (human) EESARRPKPLVDPAC K51
PAK4 (mouse) EESARRPkPLIDPAC K51-ub
PAK4 (rat) EESARRPKPLIDPAC K51
S74-p
PKTIVRGsKGAkDGA
Upstream
0 1
Treatment
  • ischemia
PAK4 (human) PKTIVRGsKGAkDGA S74-p
PAK4 iso2 (human) PKTIVRGSKGAKDGA S74
PAK4 (mouse) PKTIVRGsKGAKDGA S74-p
PAK4 (rat) PKTIVRGSKGAKDGA S74
K78-m1
VRGsKGAkDGALTLL
0 2
PAK4 (human) VRGsKGAkDGALTLL K78-m1
PAK4 iso2 (human) VRGSKGAKDGALTLL K78
PAK4 (mouse) VRGsKGAKDGALTLL K78
PAK4 (rat) VRGSKGAKDGALTLL K78
S93-p
LDEFENMsVTRsNsL
0 2
PAK4 (human) LDEFENMsVTRsNsL S93-p
PAK4 iso2 (human) LDEFENMSVTRSNSL S93
PAK4 (mouse) LDEFENMsVTRSNsL S93-p
PAK4 (rat) LDEFENMSVTRSNsL S93
S97-p
ENMsVTRsNsLRRDs
0 4
PAK4 (human) ENMsVTRsNsLRRDs S97-p
PAK4 iso2 (human) ENMSVTRSNSLRRDS S97
PAK4 (mouse) ENMsVTRSNsLRREs S97
PAK4 (rat) ENMSVTRSNsLRREs S97
S99-p
MsVTRsNsLRRDsPP
Upstream
Downstream
1 12
Effects on Modified Protein
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • cell motility, inhibited
Kinase, in vitro:
  • PRKD1 (human)
  • PRKD2 (human)
Putative in vivo kinases:
  • PRKD1 (human)
  • PRKD2 (human)
Treatment
  • CID755673
  • SII_angiotensin_2
PAK4 (human) MsVTRsNsLRRDsPP S99-p
PAK4 iso2 (human) MSVTRSNSLRRDSPP S99
PAK4 (mouse) MsVTRSNsLRREsPP S99-p
PAK4 (rat) MSVTRSNsLRREsPP S99-p
S104-p
sNsLRRDsPPPPARA
Upstream
0 47
Regulatory protein:
  • PRP4 (human)
Treatment
  • SII_angiotensin_2
PAK4 (human) sNsLRRDsPPPPARA S104-p
PAK4 iso2 (human) SNSLRRDSPPPPARA S104
PAK4 (mouse) SNsLRREsPPPPARA S104-p
PAK4 (rat) SNsLRREsPPPPARA S104-p
R126-m1
EEPATTArGGPGKAG
0 4
PAK4 (human) EEPATTArGGPGKAG R126-m1
PAK4 iso2 (human) gap -
PAK4 (mouse) EERAAPARMAPDKAG R126
PAK4 (rat) EERAALARMAPDKAG R126
S142-p
RGRFAGHsEAGGGsG
0 6
PAK4 (human) RGRFAGHsEAGGGsG S142-p
PAK4 iso2 (human) gap -
PAK4 (mouse) RARATGHsEAGsGSG S142-p
PAK4 (rat) RGRATGHSEAGSGSG S142
G146
AGHsEAGGGsGDRRR
0 1
PAK4 (human) AGHsEAGGGsGDRRR G146
PAK4 iso2 (human) gap -
PAK4 (mouse) TGHsEAGsGSGDRRR S146-p
PAK4 (rat) TGHSEAGSGSGDRRR S146
S148-p
HsEAGGGsGDRRRAG
Upstream
0 17
Treatment
  • dasatinib
  • MG132_withdrawal
  • nocodazole
  • thymidine
PAK4 (human) HsEAGGGsGDRRRAG S148-p
PAK4 iso2 (human) gap -
PAK4 (mouse) HsEAGsGSGDRRRVG S148
PAK4 (rat) HSEAGSGSGDRRRVG S148
S167-p
PKSSREGsGGPQESS
0 7
PAK4 (human) PKSSREGsGGPQESS S167-p
PAK4 iso2 (human) gap -
PAK4 (mouse) PKSSRDGPGGPQEAS P167
PAK4 (rat) PKSSREGPGGPQEVS P167
S181-p
SRDKRPLsGPDVGtP
Upstream
0 63
Regulatory protein:
  • TBK1 (human)
Treatment
  • ischemia
  • lapatinib
  • LRRK2-IN-1
  • metastatic potential
  • nocodazole
  • thymidine
  • U0126
PAK4 (human) SRDKRPLsGPDVGtP S181-p
PAK4 iso2 (human) gap -
PAK4 (mouse) SRDKRPLsGPDVStP S181-p
PAK4 (rat) SRDKRPLsGPDVSTP S181-p
T187-p
LsGPDVGtPQPAGLA
Upstream
0 17
Treatment
  • nocodazole
  • thymidine
PAK4 (human) LsGPDVGtPQPAGLA T187-p
PAK4 iso2 (human) gap -
PAK4 (mouse) LsGPDVStPQPGSLT T187-p
PAK4 (rat) LsGPDVSTPQPGSLA T187
S195-p
PQPAGLAsGAKLAAG
0 5
PAK4 (human) PQPAGLAsGAKLAAG S195-p
PAK4 iso2 (human) gap -
PAK4 (mouse) PQPGSLTSGTKLAAG S195
PAK4 (rat) PQPGSLASETKLAAG S195
T207-p
AAGRPFNtyPRADTD
Upstream
0 63
Treatment
  • ischemia
  • Y27632
PAK4 (human) AAGRPFNtyPRADTD T207-p
PAK4 iso2 (human) gap -
PAK4 (mouse) AAGRPFNtYPRADTD T207-p
PAK4 (rat) AAGRPFNTYPRADTD T207
Y208-p
AGRPFNtyPRADTDH
0 10
PAK4 (human) AGRPFNtyPRADTDH Y208-p
PAK4 iso2 (human) gap -
PAK4 (mouse) AGRPFNtYPRADTDH Y208
PAK4 (rat) AGRPFNTYPRADTDH Y208
R254-m1
SRPPTRArGAPsPGV
0 1
PAK4 (human) SRPPTRArGAPsPGV R254-m1
PAK4 iso2 (human) gap -
PAK4 (mouse) SRPPTRARGAPsPGV R253
PAK4 (rat) SRPPTRARGAPSPGV R253
S258-p
TRArGAPsPGVLGPH
Upstream
0 15
Treatment
  • nocodazole
  • thymidine
PAK4 (human) TRArGAPsPGVLGPH S258-p
PAK4 iso2 (human) gap -
PAK4 (mouse) TRARGAPsPGVLGPH S257-p
PAK4 (rat) TRARGAPSPGVLGPH S257
S267-p
GVLGPHAsEPQLAPP
Upstream
0 21
Treatment
  • MG132_withdrawal
  • nocodazole
  • thymidine
PAK4 (human) GVLGPHAsEPQLAPP S267-p
PAK4 iso2 (human) gap -
PAK4 (mouse) GVLGPHAsEPQLAPP S266-p
PAK4 (rat) GVLGPHASEPQLAPP S266
T277-p
QLAPPACtPAAPAVP
0 3
PAK4 (human) QLAPPACtPAAPAVP T277-p
PAK4 iso2 (human) gap -
PAK4 (mouse) QLAPPARALAAPAVP A276
PAK4 (rat) QLAPPARALAAPAVP A276
S291-p
PGPPGPRsPQREPQR
Upstream
0 33
Regulatory protein:
  • TBK1 (human)
Treatment
  • LRRK2-IN-1
  • nocodazole
  • SII_angiotensin_2
  • thymidine
PAK4 (human) PGPPGPRsPQREPQR S291-p
PAK4 iso2 (human) EKPPGPRSPQREPQR S126
PAK4 (mouse) PGPPGPRsPQREPQR S293-p
PAK4 (rat) PGPPGPRSPQREPQR S293
R341-m1
IVCIATVrSSGKLVA
0 1
PAK4 (human) IVCIATVrSSGKLVA R341-m1
PAK4 iso2 (human) IVCIATVRSSGKLVA R176
PAK4 (mouse) IVCIATVRSSGKLVA R343
PAK4 (rat) IVCIATVRSSGkLVA R343
K345
ATVrSSGKLVAVKKM
0 1
PAK4 (human) ATVrSSGKLVAVKKM K345
PAK4 iso2 (human) ATVRSSGKLVAVKKM K180
PAK4 (mouse) ATVRSSGKLVAVKKM K347
PAK4 (rat) ATVRSSGkLVAVKKM K347-ac
S443-p
VIHRDIKsDsILLTH
0 1
PAK4 (human) VIHRDIKsDsILLTH S443-p
PAK4 iso2 (human) VIHRDIKSDSILLTH S278
PAK4 (mouse) VIHRDIKSDSILLTH S445
PAK4 (rat) VIHRDIKSDSILLTH S445
S445-p
HRDIKsDsILLTHDG
0 1
PAK4 (human) HRDIKsDsILLTHDG S445-p
PAK4 iso2 (human) HRDIKSDSILLTHDG S280
PAK4 (mouse) HRDIKSDSILLTHDG S447
PAK4 (rat) HRDIKSDSILLTHDG S447
K455-ac
LTHDGRVkLSDFGFC
0 1
PAK4 (human) LTHDGRVkLSDFGFC K455-ac
PAK4 iso2 (human) LTHDGRVKLSDFGFC K290
PAK4 (mouse) LTHDGRVKLSDFGFC K457
PAK4 (rat) LTHDGRVKLSDFGFC K457
K467-ac
GFCAQVSkEVPRRKs
0 1
PAK4 (human) GFCAQVSkEVPRRKs K467-ac
PAK4 iso2 (human) GFCAQVSKEVPRRKS K302
PAK4 (mouse) GFCAQVSKEVPRRKs K469
PAK4 (rat) GFCAQVSKEVPRRKs K469
S474-p
kEVPRRKsLVGtPyW
Upstream
Downstream
9 202
PAK4 (human)
S474-p
PAK4 iso2 (human)
S309-p
PAK4 (mouse)
S476-p
PAK4 (rat)
S476-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell growth, altered
Kinase, in vitro:
  • PAK4 (human)
  • PRKD1 (human)
Putative in vivo kinases:
  • PAK4 (human)
Regulatory protein:
  • CDC42 iso1 (human)
  • PAK4 (human)
  • PRKD3 (human)
  • TBK1 (human)
Treatment
  • BI_4834
  • cAMP_analog
  • H-89
  • metastatic potential
  • PF3758309
  • SB431542
  • TGF-beta
PAK4 (human) kEVPRRKsLVGtPyW S474-p
PAK4 iso2 (human) KEVPRRKSLVGTPYW S309
PAK4 (mouse) KEVPRRKsLVGtPYW S476-p
PAK4 (rat) KEVPRRKsLVGTPYW S476-p
T478-p
RRKsLVGtPyWMAPE
0 39
PAK4 (human) RRKsLVGtPyWMAPE T478-p
PAK4 iso2 (human) RRKSLVGTPYWMAPE T313
PAK4 (mouse) RRKsLVGtPYWMAPE T480-p
PAK4 (rat) RRKsLVGTPYWMAPE T480
Y480-p
KsLVGtPyWMAPELI
0 1
PAK4 (human) KsLVGtPyWMAPELI Y480-p
PAK4 iso2 (human) KSLVGTPYWMAPELI Y315
PAK4 (mouse) KsLVGtPYWMAPELI Y482
PAK4 (rat) KsLVGTPYWMAPELI Y482
S488-p
WMAPELIsRLPYGPE
0 14
PAK4 (human) WMAPELIsRLPYGPE S488-p
PAK4 iso2 (human) WMAPELISRLPYGPE S323
PAK4 (mouse) WMAPELISRLPYGPE S490
PAK4 (rat) WMAPELISRLPYGPE S490
K540-ub
PRLKNLHkVSPSLKG
0 1
PAK4 (human) PRLKNLHkVSPSLKG K540-ub
PAK4 iso2 (human) PRLKNLHKVSPSLKG K375
PAK4 (mouse) PRLKNLHKASPSLkG K542
PAK4 (rat) PRLKNLHKASPSLKG K542
K546
HkVSPSLKGFLDRLL
0 1
PAK4 (human) HkVSPSLKGFLDRLL K546
PAK4 iso2 (human) HKVSPSLKGFLDRLL K381
PAK4 (mouse) HKASPSLkGFLDRLL K548-ub
PAK4 (rat) HKASPSLKGFLDRLL K548