Other Species / Isoforms
  p70S6K (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

  HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S40-p
DQPEDAGsEDELEEG
2 7
p70S6K (human) DQPEDAGsEDELEEG S40-p
p70S6K iso2 (human) DQPEDAGSEDELEEG S17
p70S6K (mouse) DQPEDAGSEDELEEG S40
p70S6K (rat) DQPEDAGsEDELEEG S40-p
p70S6K iso2 (rat) DQPEDAGsEDELEEG S17-p
p70S6K (fruit fly) IELDDVDLEPELCIN L40
S53-p
EGGQLNEsMDHGGVG
Upstream
1 0
Kinase, in vitro:
  • NEK6 (human)
p70S6K (human) EGGQLNEsMDHGGVG S53-p
p70S6K iso2 (human) EGGQLNESMDHGGVG S30
p70S6K (mouse) EGGQLNESMDHGGVG S53
p70S6K (rat) EGGQLNESMDHGGVG S53
p70S6K iso2 (rat) EGGQLNESMDHGGVG S30
p70S6K (fruit fly) PELCINLHQDTEGQE H49
Y62
DHGGVGPYELGMEHC
1 0
p70S6K (human) DHGGVGPYELGMEHC Y62
p70S6K iso2 (human) DHGGVGPYELGMEHC Y39
p70S6K (mouse) DHGGVGPYELGMEHC Y62
p70S6K (rat) DHGGVGPyELGMEHC Y62-p
p70S6K iso2 (rat) DHGGVGPYELGMEHC Y39
p70S6K (fruit fly) gap -
K85-ub
SVNRGPEkIRPECFE
0 1
p70S6K (human) SVNRGPEkIRPECFE K85-ub
p70S6K iso2 (human) SVNRGPEKIRPECFE K62
p70S6K (mouse) SVNRGPEKIRPECFE K85
p70S6K (rat) SVNRGPEKIRPECFE K85
p70S6K iso2 (rat) SVNRGPEKIRPECFE K62
p70S6K (fruit fly) NVNPGKIKLGPKDFE K71
K104-ub
LGKGGYGkVFQVRKV
0 3
p70S6K (human) LGKGGYGkVFQVRKV K104-ub
p70S6K iso2 (human) LGKGGYGKVFQVRKV K81
p70S6K (mouse) LGKGGYGkVFQVRKV K104-ub
p70S6K (rat) LGKGGYGKVFQVRKV K104
p70S6K iso2 (rat) LGKGGYGKVFQVRKV K81
p70S6K (fruit fly) LGKGGYGKVFQVRKT K90
K118-ub
VTGANTGkIFAMKVL
0 1
p70S6K (human) VTGANTGkIFAMKVL K118-ub
p70S6K iso2 (human) VTGANTGKIFAMKVL K95
p70S6K (mouse) VTGANTGKIFAMkVL K118
p70S6K (rat) VTGANTGKIFAMKVL K118
p70S6K iso2 (rat) VTGANTGKIFAMKVL K95
p70S6K (fruit fly) TAGRDANKYFAMKVL K104
K123
TGkIFAMKVLKKAMI
0 1
p70S6K (human) TGkIFAMKVLKKAMI K123
p70S6K iso2 (human) TGKIFAMKVLKKAMI K100
p70S6K (mouse) TGKIFAMkVLkKAMI K123-ac
p70S6K (rat) TGKIFAMKVLKKAMI K123
p70S6K iso2 (rat) TGKIFAMKVLKKAMI K100
p70S6K (fruit fly) ANKYFAMKVLKKASI K109
K126
IFAMKVLKKAMIVRN
0 1
p70S6K (human) IFAMKVLKKAMIVRN K126
p70S6K iso2 (human) IFAMKVLKKAMIVRN K103
p70S6K (mouse) IFAMkVLkKAMIVRN K126-ac
p70S6K (rat) IFAMKVLKKAMIVRN K126
p70S6K iso2 (rat) IFAMKVLKKAMIVRN K103
p70S6K (fruit fly) YFAMKVLKKASIVTN K112
T140
NAKDTAHTKAERNIL
0 1
p70S6K (human) NAKDTAHTKAERNIL T140
p70S6K iso2 (human) NAKDTAHTKAERNIL T117
p70S6K (mouse) NAKDTAHtKAERNIL T140-p
p70S6K (rat) NAKDTAHTKAERNIL T140
p70S6K iso2 (rat) NAKDTAHTKAERNIL T117
p70S6K (fruit fly) NQKDTAHTRAERNIL T126
R217
HQKGIIYRDLKPENI
0 2
p70S6K (human) HQKGIIYRDLKPENI R217
p70S6K iso2 (human) HQKGIIYRDLKPENI R194
p70S6K (mouse) HQKGIIYrDLKPENI R217-m1
p70S6K (rat) HQKGIIYRDLKPENI R217
p70S6K iso2 (rat) HQKGIIYRDLKPENI R194
p70S6K (fruit fly) HKLGIIYRDLKPENI R203
S243-p
DFGLCKEsIHDGtVt
Upstream
0 6
Treatment
  • gefitinib
p70S6K (human) DFGLCKEsIHDGtVt S243-p
p70S6K iso2 (human) DFGLCKESIHDGTVT S220
p70S6K (mouse) DFGLCKEsIHDGtVt S243-p
p70S6K (rat) DFGLCKESIHDGTVT S243
p70S6K iso2 (rat) DFGLCKESIHDGTVT S220
p70S6K (fruit fly) DFGLCKEHIQEGIVT H229
T248-p
KEsIHDGtVtHtFCG
Upstream
0 6
Treatment
  • imatinib
p70S6K (human) KEsIHDGtVtHtFCG T248-p
p70S6K iso2 (human) KESIHDGTVTHtFCG T225
p70S6K (mouse) KEsIHDGtVtHtFCG T248-p
p70S6K (rat) KESIHDGTVTHtFCG T248
p70S6K iso2 (rat) KESIHDGTVTHTFCG T225
p70S6K (fruit fly) KEHIQEGIVTHTFCG I234
T250-p
sIHDGtVtHtFCGtI
Upstream
0 12
Treatment
  • gefitinib
p70S6K (human) sIHDGtVtHtFCGtI T250-p
p70S6K iso2 (human) SIHDGTVTHtFCGTI T227
p70S6K (mouse) sIHDGtVtHtFCGtI T250-p
p70S6K (rat) SIHDGTVTHtFCGTI T250
p70S6K iso2 (rat) SIHDGTVTHTFCGTI T227
p70S6K (fruit fly) HIQEGIVTHTFCGTI T236
T252-p
HDGtVtHtFCGtIEY
Upstream
Downstream
35 19
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • cell growth, inhibited
  • translation, altered
  • translation, inhibited
Kinase, in vitro:
  • PDK1 (human)
Phosphatases, in vitro:
  • PHLPP (human)
  • PHLPP2 (human)
Putative in vivo kinases:
  • PDK1 (human)
  • PIK3CA (human)
Putative upstream phosphatases:
  • PHLPP (human)
  • PHLPP2 (human)
Regulatory protein:
  • PPP2CA (human)
  • TSC1 (mouse)
  • TSC2 (mouse)
  • ULK1 (human)
view more >
Treatment
  • alkaline pH
  • alpelisib
  • amino_acid_starvation
  • amino_acids
  • EGF
  • EGTA
  • FK506
  • gefitinib
  • IGF-1
  • insulin
  • LY294002
  • medium change
  • methylxanthine
  • MK-2206
  • OSU-03012
  • peptide inhibitor
  • rapamycin
  • serum
  • serum_starvation
  • siRNA
  • virus infection
  • wortmannin
view more >
p70S6K (human) HDGtVtHtFCGtIEY T252-p
p70S6K iso2 (human) HDGTVTHtFCGTIEY T229-p
p70S6K (mouse) HDGtVtHtFCGtIEY T252-p
p70S6K (rat) HDGTVTHtFCGTIEY T252-p
p70S6K iso2 (rat) HDGTVTHTFCGTIEY T229
p70S6K (fruit fly) QEGIVTHTFCGTIEY T238
T256-p
VtHtFCGtIEYMAPE
Upstream
0 6
Treatment
  • imatinib
p70S6K (human) VtHtFCGtIEYMAPE T256-p
p70S6K iso2 (human) VTHtFCGTIEYMAPE T233
p70S6K (mouse) VtHtFCGtIEYMAPE T256-p
p70S6K (rat) VTHtFCGTIEYMAPE T256
p70S6K iso2 (rat) VTHTFCGTIEYMAPE T233
p70S6K (fruit fly) VTHTFCGTIEYMAPE T242
K304-ac
NRKKTIDkILKCKLN
0 3
p70S6K (human) NRKKTIDkILKCKLN K304-ac
p70S6K iso2 (human) NRKKTIDKILKCKLN K281
p70S6K (mouse) NRKKTIDKILKCKLN K304
p70S6K (rat) NRKKTIDkILKCKLN K304-ac
p70S6K iso2 (rat) NRKKTIDKILKCKLN K281
p70S6K (fruit fly) NRKKTIETILKAKLN T290
K364-ub
WEELLARkVEPPFkP
0 1
p70S6K (human) WEELLARkVEPPFkP K364-ub
p70S6K iso2 (human) WEELLARKVEPPFKP K341
p70S6K (mouse) WEELLARKVEPPFKP K364
p70S6K (rat) WEELLARKVEPPFKP K364
p70S6K iso2 (rat) WEELLARKVEPPFKP K341
p70S6K (fruit fly) WDDVLARRLEPPIKP R350
K370-ub
RkVEPPFkPLLQSEE
0 1
p70S6K (human) RkVEPPFkPLLQSEE K370-ub
p70S6K iso2 (human) RKVEPPFKPLLQSEE K347
p70S6K (mouse) RKVEPPFKPLLQSEE K370
p70S6K (rat) RKVEPPFKPLLQSEE K370
p70S6K iso2 (rat) RKVEPPFKPLLQSEE K347
p70S6K (fruit fly) RRLEPPIKPLLRSED K356
T390-p
DSKFTRQtPVDsPDD
3 14
p70S6K (human) DSKFTRQtPVDsPDD T390-p
p70S6K iso2 (human) DSKFTRQTPVDsPDD T367
p70S6K (mouse) DSKFTRQtPVDsPDD T390-p
p70S6K (rat) DSKFTRQTPVDsPDD T390
p70S6K iso2 (rat) DSKFTRQTPVDSPDD T367
p70S6K (fruit fly) DTRFTRQIPVDSPDD I376
S394-p
TRQtPVDsPDDStLS
Upstream
Downstream
18 15
p70S6K (human)
S394-p
p70S6K (mouse)
S394-p
p70S6K (rat)
S394-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • protein conformation
Kinase, in vitro:
  • mTOR (human)
  • mTOR (mouse)
Putative in vivo kinases:
  • CDK1 (human)
  • mTOR (human)
  • PDK1 (human)
view more >
Regulatory protein:
  • FOXO1A (human)
  • SESN3 (human)
Treatment
  • insulin
  • metformin
  • NVP-BKM120
  • osteopontin
  • rapamycin
  • serum
  • wortmannin
view more >
p70S6K (human) TRQtPVDsPDDStLS S394-p
p70S6K iso2 (human) TRQTPVDsPDDSTLS S371-p
p70S6K (mouse) TRQtPVDsPDDSTLS S394-p
p70S6K (rat) TRQTPVDsPDDSTLS S394-p
p70S6K iso2 (rat) TRQTPVDSPDDSTLS S371
p70S6K (fruit fly) TRQIPVDSPDDTTLS S380
T399-p
VDsPDDStLSEsANQ
0 1
p70S6K (human) VDsPDDStLSEsANQ T399-p
p70S6K iso2 (human) VDsPDDSTLSESANQ T376
p70S6K (mouse) VDsPDDSTLSESANQ T399
p70S6K (rat) VDsPDDSTLSESANQ T399
p70S6K iso2 (rat) VDSPDDSTLSESANQ T376
p70S6K (fruit fly) VDSPDDTTLSESANL T385
S403-p
DDStLSEsANQVFLG
Upstream
1 2
Kinase, in vitro:
  • NEK6 (human)
p70S6K (human) DDStLSEsANQVFLG S403-p
p70S6K iso2 (human) DDSTLSESANQVFLG S380
p70S6K (mouse) DDSTLSESANQVFLG S403
p70S6K (rat) DDSTLSESANQVFLG S403
p70S6K iso2 (rat) DDSTLSESANQVFLG S380
p70S6K (fruit fly) DDTTLSESANLIFQG S389
T412-p
NQVFLGFtyVAPsVL
Upstream
Downstream
512 12
p70S6K (human)
T412-p
p70S6K iso2 (human)
T389-p
p70S6K (mouse)
T412-p
p70S6K (rat)
T412-p
p70S6K iso2 (rat)
T389-p
p70S6K (fruit fly)
T398-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • apoptosis, inhibited
  • autophagy, induced
  • autophagy, inhibited
  • carcinogenesis, induced
  • carcinogenesis, inhibited
  • cell adhesion, altered
  • cell cycle regulation
  • cell growth, induced
  • cell growth, inhibited
  • cell motility, induced
  • signaling pathway regulation
  • transcription, altered
  • transcription, induced
  • translation, altered
  • translation, induced
  • translation, inhibited
Kinase, in vitro:
  • mTOR (human)
  • NEK6 (human)
  • PDK1 (human)
view more >
Phosphatases, in vitro:
  • PHLPP (human)
  • PHLPP2 (human)
  • PPP1CC (human)
  • PPP2R5C (human)
view more >
Putative in vivo kinases:
  • mTOR (human)
  • p70S6K (human)
  • PDK1 (human)
  • PIK3CA (human)
view more >
Putative upstream phosphatases:
  • PHLPP (human)
  • PHLPP2 (human)
  • PPP1CC (human)
  • PPP2CA (human)
  • PPP2R5C (human)
view more >
Regulatory protein:
  • ACLY (human)
  • ACSL4 (human)
  • AKAP13 (human)
  • AKAP8L (human)
  • Akt1 (human)
  • Akt2 (human)
  • Akt3 (human)
  • ALDOB (human)
  • AMPKA1 (human)
  • AP2M1 (human)
  • ARF GAP1 (human)
  • ARL8B (human)
  • ATF-4 (human)
  • ATG13 (human)
  • ATG5 (human)
  • AUH (human)
  • BNIP3 (human)
  • CIP2A (human)
  • CK1E (human)
  • CLTC (human)
  • DAPK3 (human)
  • DDIT4 (human)
  • DDIT4L (human)
  • DDX48 (human)
  • DEPDC5 (human)
  • DEPTOR (human)
  • DJ-1 (human)
  • DUSP6 (human)
  • DYRK3 (human)
  • EWS (human)
  • FAK (human)
  • FGFR1 (human)
  • FLCN (human)
  • FLI1 (human)
  • FOXO1A (human)
  • FRS2 (human)
  • GCK (human)
  • GCN5 (human)
  • GPR141 (human)
  • GSK3A (human)
  • GSK3B (human)
  • HERC1 (human)
  • HGK (human)
  • HIF1A (human)
  • HMGCL (human)
  • HMOX1 (human)
  • hnRNP D0 (human)
  • HPK1 (human)
  • HRas (human)
  • HSF1 (human)
  • IKKA (human)
  • JMJD1A (human)
  • JMJD1B (human)
  • KHS2 (human)
  • lamin A/C (human)
  • LAMTOR1 (human)
  • LAMTOR2 (human)
  • LAMTOR3 (human)
  • LARS (human)
  • LATS1 (human)
  • LATS2 (human)
  • LST8 (human)
  • MAGE-A6 (human)
  • MAGEA3 (human)
  • MCCC1 (human)
  • Merlin (human)
  • MINK (human)
  • MKK6 (human)
  • Mnk1 (human)
  • MST1 (human)
  • MST2 (human)
  • mTOR (human)
  • NAA20 (human)
  • Notch 1 (human)
  • NRF2 (human)
  • OSBPL9 (human)
  • p27Kip1 (human)
  • p300 (human)
  • P38A (human)
  • p53 (human)
  • p70S6K (human)
  • PCAF (human)
  • PIK3C2B (human)
  • PINK1 (human)
  • PKCA (human)
  • PKD1 (human)
  • PKM (human)
  • PKM iso2 (human)
  • PLK1 (human)
  • PPP1CC (human)
  • PPP2CA (human)
  • PPP2R5A (human)
  • PPP3CA (human)
  • PRAS40 (human)
  • PRAS40 iso3 (human)
  • PRKD1 (human)
  • PTEN (human)
  • RAF1 (human)
  • RAG1 (human)
  • Raptor (human)
  • Ret (human)
  • RFX7 (human)
  • RHEB (human)
  • RICTOR (human)
  • RMP (human)
  • RRAGA (human)
  • RRAGB (human)
  • RRAGC (human)
  • SAV1 (human)
  • SESN2 (human)
  • SET (human)
  • Sin1 (human)
  • SKAR (human)
  • SLC1A5 (human)
  • SLC23A1 (human)
  • SLC23A2 (human)
  • SLC3A2 (human)
  • SLC7A5 (human)
  • SMAD2 (human)
  • SMAD3 (human)
  • SMAD4 (human)
  • SMPD3 (human)
  • SPOP (human)
  • SPRY2 (human)
  • TMEM102 (human)
  • TRAF2 (human)
  • TRAF4 (human)
  • TRIM7 (human)
  • TSC1 (human)
  • TSC1 (mouse)
  • TSC2 (human)
  • TSC2 (mouse)
  • ULK1 (human)
  • ULK2 (human)
  • WWTR1 (human)
  • YAP1 (human)
  • ZNF289 (human)
view more >
Treatment
  • 1,25_dihydroxyvitamin_D
  • 1,25D
  • 1-azakenpaullone
  • 17-beta-estradiol
  • 2-deoxyglucose
  • 3-hydroxy-3-methylglutaryl-coenzyme A
  • 3-Methyladenine
  • 4-HT
  • 5(S)-HETE
  • 5-cholesten-5-beta-ol
  • 8-CPT-2Me-cAMP
  • A-443654
  • A6730
  • acadesine
  • AcCoA
  • acetominophen
  • AG1024
  • AG1296
  • AG1478
  • AG490
  • Akt-I-1,2
  • alkaline pH
  • alpelisib
  • alpha-ketoisocaproate
  • ALW-II-41-27
  • amino_acid_starvation
  • amino_acids
  • angiotensin
  • angiotensin_2
  • anisomycin
  • antibody
  • apelin
  • APV
  • AR-A014418
  • argimesna
  • arginine deprivation
  • arsenite
  • ascorbic_acid
  • Asparagine
  • aspirin
  • ATP
  • AZD2014
  • AZD8055
  • BafA1
  • Benzyl Isothiocyanate
  • bisindolylmaleimide
  • blood pressure
  • BMS-754807
  • C646
  • calyculin_A
  • cannabidiol
  • carbachol
  • cariporide
  • CBHA
  • CBL0137
  • Cbz-B3A
  • CGP57380
  • CHIR99021
  • chloroquine
  • cholesterol_oxidase
  • ciclopirox_olamine
  • colforsin
  • compound S-4
  • compound_C
  • copanlisib
  • CPD-18
  • CTB
  • CuSO4
  • cycloheximide
  • dabrafenib
  • dactolisib
  • DAMGO
  • DCA
  • deferoxamine
  • depolarization
  • dexamethasone
  • DG2
  • dinoprost
  • dovitinib
  • doxycycline
  • Dp44mT
  • EGF
  • endothelin
  • ephrin_A1
  • Epo
  • erlotinib
  • estradiol
  • ethanol
  • exercise
  • FCCP
  • Fe
  • FGF1
  • FGF2
  • fibronectin
  • Filipin
  • fingolimod
  • FK506
  • fluoromethylketone
  • Fortetropin
  • Ganetespib
  • GDC0068
  • GDNF
  • gefitinib
  • GF109203X
  • glucose
  • glucose_starvation
  • glutamic acid
  • glutamine
  • GM-CSF
  • Go_6796
  • GSK-626616
  • GSK690693
  • H-89
  • H2O2
  • HCQ
  • herbimycin_A
  • heregulin
  • high_cell_density
  • high_glucose
  • HMTBA
  • HPLM
  • IBMX
  • IFN-gamma
  • IGF-1
  • IL-6
  • imatinib
  • indometacin
  • infigratinib
  • INK-128
  • insulin
  • ionizing_radiation
  • ionomycin
  • isoleucine
  • itraconazol
  • JQ1
  • kb_NB_142-70
  • KP-372-1
  • KP-372-2
  • KU-0063794
  • L-744,832
  • L-glutamine_withdrawal
  • L-methionine
  • laminar flow
  • lapatinib
  • latrunculin_B
  • LB-100
  • leucine
  • leucine_deprivation
  • linsitinib
  • liothyronine
  • lithium
  • long-term_potentiation
  • low_glucose
  • LPA
  • LPS
  • LY-2584702
  • LY294002
  • meal feeding
  • medium change
  • metformin
  • methyl-beta-cyclodextrin
  • methylxanthine
  • MG132
  • MHY1485
  • mifepristone
  • miR-451
  • MK-2206
  • monensin
  • monodansylcadaverine
  • MS275
  • NAC
  • naloxone
  • NBQX
  • NH4Cl
  • nifedipine
  • nilotinib
  • nitric_oxide
  • NKH_477
  • NMDA
  • nocodazole
  • NSC-45586
  • nutlin-3A
  • obesity
  • okadaic_acid
  • oscillatory_flow
  • OSI-027
  • osteopontin
  • palbociclib
  • palmitate
  • PD98059
  • PDGF
  • pemetrexed
  • peptide
  • peptide inhibitor
  • PF-04691502
  • PF-670462
  • phorbol_ester
  • PI-103
  • picropodophyllin
  • pictilisib
  • pimenta doica
  • PKC_inhibitor_myristoylated
  • PKI-402
  • PP1
  • PP2
  • PP242
  • preformed fibrils
  • pregnancy
  • PTX
  • QLT0254
  • RAD001
  • rapalink1
  • rapamycin
  • resveratrol
  • retinoic_acid
  • RGD
  • RGFP966
  • rosiglitazone
  • rottlerin
  • salicylate
  • SAM
  • SB202190
  • SB203580
  • SB216763
  • SB431542
  • SCF
  • SCH772984
  • seocalcitol
  • serum
  • serum_starvation
  • serum_withdrawal
  • SGI-1027
  • SGI-1776
  • SH-6
  • sildenafil
  • silmitasertib
  • simvastatin
  • siRNA
  • sorafenib
  • sorbitol
  • SP600125
  • spermidine
  • sphingosine_1-phosphate
  • starvation
  • STO-609
  • sulforaphane
  • taxol
  • temsirolimus
  • TGF-beta
  • thapsigargin
  • thrombin
  • tioguanine
  • Torin1
  • Trametinib
  • tunicamycin
  • U0126
  • UV
  • V-9302
  • valine
  • vanadate
  • VE-821
  • virus infection
  • wortmannin
  • WYE132
  • Y320
  • Zn(2+)
  • ZnPPIX
view more >
p70S6K (human) NQVFLGFtyVAPsVL T412-p
p70S6K iso2 (human) NQVFLGFtYVAPSVL T389-p
p70S6K (mouse) NQVFLGFtYVAPSVL T412-p
p70S6K (rat) NQVFLGFtYVAPSVL T412-p
p70S6K iso2 (rat) NQVFLGFtYVAPSVL T389-p
p70S6K (fruit fly) NLIFQGFTYVAPSIL T398
Y413-p
QVFLGFtyVAPsVLE
0 2
p70S6K (human) QVFLGFtyVAPsVLE Y413-p
p70S6K iso2 (human) QVFLGFtYVAPSVLE Y390
p70S6K (mouse) QVFLGFtYVAPSVLE Y413
p70S6K (rat) QVFLGFtYVAPSVLE Y413
p70S6K iso2 (rat) QVFLGFtYVAPSVLE Y390
p70S6K (fruit fly) LIFQGFTYVAPSILE Y399
S417-p
GFtyVAPsVLEsVKE
0 1
p70S6K (human) GFtyVAPsVLEsVKE S417-p
p70S6K iso2 (human) GFtYVAPSVLESVKE S394
p70S6K (mouse) GFtYVAPSVLESVKE S417
p70S6K (rat) GFtYVAPSVLESVKE S417
p70S6K iso2 (rat) GFtYVAPSVLESVKE S394
p70S6K (fruit fly) GFTYVAPSILEDMHR S403
S421-p
VAPsVLEsVKEkFsF
0 2
p70S6K (human) VAPsVLEsVKEkFsF S421-p
p70S6K iso2 (human) VAPSVLESVKEKFSF S398
p70S6K (mouse) VAPSVLESVKEKFsF S421
p70S6K (rat) VAPSVLESVKEKFSF S421
p70S6K iso2 (rat) VAPSVLESVKEKFSF S398
p70S6K (fruit fly) VAPSILEDMHRANRM D407
K425-ub
VLEsVKEkFsFEPKI
0 1
p70S6K (human) VLEsVKEkFsFEPKI K425-ub
p70S6K iso2 (human) VLESVKEKFSFEPKI K402
p70S6K (mouse) VLESVKEKFsFEPKI K425
p70S6K (rat) VLESVKEKFSFEPKI K425
p70S6K iso2 (rat) VLESVKEKFSFEPKI K402
p70S6K (fruit fly) gap -
S427-p
EsVKEkFsFEPKIRs
Upstream
Downstream
5 13
Effects on Modified Protein
  • enzymatic activity, induced
Treatment
  • EGTA
  • FK506
  • ischemia
  • methylxanthine
  • rapamycin
  • serum
  • vemurafenib
  • wortmannin
view more >
p70S6K (human) EsVKEkFsFEPKIRs S427-p
p70S6K iso2 (human) ESVKEKFSFEPKIRs S404
p70S6K (mouse) ESVKEKFsFEPKIRs S427-p
p70S6K (rat) ESVKEKFSFEPKIRs S427
p70S6K iso2 (rat) ESVKEKFSFEPKIRS S404
p70S6K (fruit fly) ILEDMHRANRMPARS A411
S434-p
sFEPKIRsPRRFIGs
Upstream
Downstream
29 1
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (human)
  • ERK2 (mouse)
  • JNK1 (mouse)
  • JNK2 (mouse)
view more >
Putative in vivo kinases:
  • CDK1 (human)
  • mTOR (human)
Regulatory protein:
  • CUL4B (human)
  • FRS2 (human)
  • TSC1 (mouse)
  • TSC2 (mouse)
view more >
Treatment
  • bisindolylmaleimide
  • EGF
  • EGTA
  • FGF1
  • FK506
  • heregulin
  • IGF-1
  • IL-6
  • insulin
  • LY294002
  • methylxanthine
  • nocodazole
  • PD98059
  • phorbol_ester
  • purvalanol
  • rapamycin
  • SB202190
  • seliciclib
  • serum
  • taxol
  • U0126
  • UV
  • vanadate
  • wortmannin
view more >
p70S6K (human) sFEPKIRsPRRFIGs S434-p
p70S6K iso2 (human) SFEPKIRsPRRFIGs S411-p
p70S6K (mouse) sFEPKIRsPRRFIGs S434-p
p70S6K (rat) SFEPKIRsPRRFIGs S434-p
p70S6K iso2 (rat) SFEPKIRSPRRFIGS S411
p70S6K (fruit fly) ANRMPARSPRRTPRQ S418
S441-p
sPRRFIGsPRtPVsP
Upstream
Downstream
11 118
Effects on Modified Protein
  • enzymatic activity, induced
Treatment
  • angiotensin_2
  • EGF
  • EGTA
  • ischemia
  • metformin
  • methylxanthine
  • nocodazole
  • rapamycin
  • SB202190
  • serum
  • SII_angiotensin_2
  • wortmannin
view more >
p70S6K (human) sPRRFIGsPRtPVsP S441-p
p70S6K iso2 (human) sPRRFIGsPRtPVsP S418-p
p70S6K (mouse) sPRRFIGsPRtPVsP S441-p
p70S6K (rat) sPRRFIGsPRtPVsP S441-p
p70S6K iso2 (rat) SPRRFIGSPRtPVsP S418
p70S6K (fruit fly) PARSPRRTPRQLPDS T422
T444-p
RFIGsPRtPVsPVkF
Upstream
Downstream
111 142
p70S6K (human)
T444-p
p70S6K (mouse)
T444-p
p70S6K (rat)
T444-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • carcinogenesis, induced
  • cell adhesion, altered
  • cell cycle regulation
  • cell growth, induced
  • signaling pathway regulation
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (human)
  • TBK1 (human)
view more >
Regulatory protein:
  • DDIT4 (human)
  • DDIT4L (human)
  • DUSP6 (human)
  • FAK (human)
  • FRS2 (human)
  • LKB1 (human)
  • mTOR (human)
  • PDCD6 (human)
  • PIK3R1 (human)
  • PIK3R2 (human)
  • RAF1 (human)
  • SHIP (human)
  • TBK1 (human)
  • TSC2 (human)
view more >
Treatment
  • 1,25D
  • 1-butanol
  • 5-cholesten-5-beta-ol
  • actinomycin_D
  • AEE788
  • AG1478
  • angiotensin_2
  • antibody
  • apelin
  • As2O3
  • BAPTA-AM
  • bisindolylmaleimide
  • blood pressure
  • cholesterol_oxidase
  • colforsin
  • cycloheximide
  • DAMGO
  • dexamethasone
  • dinoprost
  • EGF
  • EGTA
  • exercise
  • FGF1
  • fibronectin
  • Filipin
  • fingolimod
  • FK506
  • GF109203X
  • glucose
  • GM-CSF
  • H2O2
  • herbimycin_A
  • heregulin
  • histamine
  • hypertonic_buffer
  • IFN-alpha
  • IFN-beta
  • IFN-gamma
  • IGF-1
  • IL-6
  • imatinib
  • insulin
  • ionizing_radiation
  • ischemia
  • LY294002
  • mepyramine
  • methyl-beta-cyclodextrin
  • methylxanthine
  • monensin
  • monodansylcadaverine
  • naloxone
  • nocodazole
  • osteopontin
  • PD184352
  • PD90059
  • PD98059
  • PDGF
  • phorbol_ester
  • pictilisib
  • PKC_inhibitor_myristoylated
  • PP1
  • PP2
  • PTX
  • purvalanol
  • RAD001
  • rapamycin
  • retinoic_acid
  • RGD
  • Ro31-8425
  • rosiglitazone
  • SB202190
  • SB203580
  • SCF
  • seliciclib
  • serum
  • SH-6
  • SII_angiotensin_2
  • simvastatin
  • siRNA
  • SP600125
  • t-butanol
  • taxol
  • thioperamide
  • thrombin
  • tiotidine
  • U0126
  • U73122
  • UV
  • vanadate
  • VEGF
  • wortmannin
  • Zn(2+)
view more >
p70S6K (human) RFIGsPRtPVsPVkF T444-p
p70S6K iso2 (human) RFIGsPRtPVsPVKF T421-p
p70S6K (mouse) RFIGsPRtPVsPVKF T444-p
p70S6K (rat) RFIGsPRtPVsPVKF T444-p
p70S6K iso2 (rat) RFIGSPRtPVsPVKF T421-p
p70S6K (fruit fly) gap -
S447-p
GsPRtPVsPVkFsPG
Upstream
Downstream
107 299
p70S6K (human)
S447-p
p70S6K (mouse)
S447-p
p70S6K (rat)
S447-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell cycle regulation
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (human)
  • TBK1 (human)
view more >
Putative in vivo kinases:
  • CDK1 (human)
Regulatory protein:
  • DDIT4 (human)
  • DDIT4L (human)
  • DUSP6 (human)
  • FAK (human)
  • FRS2 (human)
  • mTOR (human)
  • PIK3R1 (human)
  • PIK3R2 (human)
  • RAF1 (human)
  • SHIP (human)
  • TBK1 (human)
  • TSC2 (human)
view more >
Treatment
  • 1,25D
  • 1-butanol
  • 2-deoxyglucose
  • 5-cholesten-5-beta-ol
  • actinomycin_D
  • AEE788
  • AG1478
  • angiotensin_2
  • antibody
  • apelin
  • As2O3
  • BAPTA-AM
  • bisindolylmaleimide
  • blood pressure
  • cholesterol_oxidase
  • colforsin
  • cycloheximide
  • DAMGO
  • dexamethasone
  • EGF
  • EGTA
  • exercise
  • FGF1
  • fibronectin
  • Filipin
  • fingolimod
  • FK506
  • GF109203X
  • glucose
  • GM-CSF
  • H2O2
  • herbimycin_A
  • heregulin
  • histamine
  • hypertonic_buffer
  • IFN-alpha
  • IFN-beta
  • IFN-gamma
  • IGF-1
  • IL-6
  • imatinib
  • insulin
  • ionizing_radiation
  • ischemia
  • LY294002
  • mepyramine
  • methyl-beta-cyclodextrin
  • methylxanthine
  • monensin
  • monodansylcadaverine
  • naloxone
  • nocodazole
  • osteopontin
  • PD184352
  • PD90059
  • PD98059
  • PDGF
  • phorbol_ester
  • PKC_inhibitor_myristoylated
  • PP1
  • PP2
  • PTX
  • purvalanol
  • RAD001
  • rapamycin
  • RGD
  • Ro31-8425
  • rosiglitazone
  • SB202190
  • SB203580
  • SCF
  • seliciclib
  • serum
  • SH-6
  • SII_angiotensin_2
  • simvastatin
  • siRNA
  • SP600125
  • t-butanol
  • taxol
  • thioperamide
  • thrombin
  • tiotidine
  • Torin1
  • U0126
  • U73122
  • UV
  • vanadate
  • virus infection
  • wortmannin
  • Zn(2+)
view more >
p70S6K (human) GsPRtPVsPVkFsPG S447-p
p70S6K iso2 (human) GsPRtPVsPVKFsPG S424-p
p70S6K (mouse) GsPRtPVsPVKFsPG S447-p
p70S6K (rat) GsPRtPVsPVKFsPG S447-p
p70S6K iso2 (rat) GSPRtPVsPVKFSPG S424-p
p70S6K (fruit fly) gap -
K450-ub
RtPVsPVkFsPGDFW
0 1
p70S6K (human) RtPVsPVkFsPGDFW K450-ub
p70S6K iso2 (human) RtPVsPVKFsPGDFW K427
p70S6K (mouse) RtPVsPVKFsPGDFW K450
p70S6K (rat) RtPVsPVKFsPGDFW K450
p70S6K iso2 (rat) RtPVsPVKFSPGDFW K427
p70S6K (fruit fly) SPRRTPRQLPDSSFR Q425
S452-p
PVsPVkFsPGDFWGR
Upstream
2 98
Treatment
  • nocodazole
  • rapamycin
  • Torin1
view more >
p70S6K (human) PVsPVkFsPGDFWGR S452-p
p70S6K iso2 (human) PVsPVKFsPGDFWGR S429-p
p70S6K (mouse) PVsPVKFsPGDFWGR S452-p
p70S6K (rat) PVsPVKFsPGDFWGR S452-p
p70S6K iso2 (rat) PVsPVKFSPGDFWGR S429
p70S6K (fruit fly) RRTPRQLPDSSFRLQ P427
S462-p
DFWGRGAsASTANPQ
0 1
p70S6K (human) DFWGRGAsASTANPQ S462-p
p70S6K iso2 (human) DFWGRGASASTANPQ S439
p70S6K (mouse) DFWGRGASASTANPQ S462
p70S6K (rat) DFWGRGASASTANPQ S462
p70S6K iso2 (rat) DFWGRGASASTANPQ S439
p70S6K (fruit fly) SFRLQFPSANVGANA S437
T470-p
ASTANPQtPVEYPME
1 0
p70S6K (human) ASTANPQtPVEYPME T470-p
p70S6K iso2 (human) ASTANPQTPVEYPME T447
p70S6K (mouse) ASTANPQTPVEYPME T470
p70S6K (rat) ASTANPQTPVEYPME T470
p70S6K iso2 (rat) ASTANPQTPVEYPME T447
p70S6K (fruit fly) gap -
S489
EQMDVTMSGEASAPL
1 0
p70S6K (human) EQMDVTMSGEASAPL S489
p70S6K iso2 (human) EQMDVTMSGEASAPL S466
p70S6K (mouse) EQMDVTVsGEASAPL S489-gl
p70S6K (rat) EQMDVTTSGEASAPL S489
p70S6K iso2 (rat) EQMDVTTSGEASAPL S466
p70S6K (fruit fly) MHGHSQRSGMFARAT S455
K507
QPNSGPYKKQAFPMI
3 0
p70S6K (human) QPNSGPYKKQAFPMI K507
p70S6K iso2 (human) QPNSGPYkkQAFPMI K484-ac
p70S6K (mouse) QPNSGPYkkQAFPMI K507-ac
p70S6K (rat) QPNSGPYKKQAFPMI K507
p70S6K iso2 (rat) QPNSGPYKKQAFPMI K484
p70S6K (fruit fly) ARATPPHHMQTFAPR H466
K508
PNSGPYKKQAFPMIS
3 0
p70S6K (human) PNSGPYKKQAFPMIS K508
p70S6K iso2 (human) PNSGPYkkQAFPMIS K485-ac
p70S6K (mouse) PNSGPYkkQAFPMIS K508-ac
p70S6K (rat) PNSGPYKKQAFPMIS K508
p70S6K iso2 (rat) PNSGPYKKQAFPMIS K485
p70S6K (fruit fly) RATPPHHMQTFAPRP M467
K516-ac
QAFPMISkRPEHLrM
Upstream
4 1
Regulatory protein:
  • PCAF (human)
Treatment
  • arsenite
  • H2O2
  • IGF-1
  • insulin
  • LY294002
  • PDGF
  • rapamycin
  • serum
  • sorbitol
  • trichostatin_A
view more >
p70S6K (human) QAFPMISkRPEHLrM K516-ac
p70S6K iso2 (human) QAFPMISkRPEHLRM K493-ac
p70S6K (mouse) QAFPMISkRPEHLRM K516-ac
p70S6K (rat) QAFPMISKRPEHLRM K516
p70S6K iso2 (rat) QAFPMISKRPEHLRM K493
p70S6K (fruit fly) TFAPRPSPAQDEMMD P476
R522-m1
SkRPEHLrMNL____
0 1
p70S6K (human) SkRPEHLrMNL____ R522-m1
p70S6K iso2 (human) SkRPEHLRMNL____ R499
p70S6K (mouse) SkRPEHLRMNL____ R522
p70S6K (rat) SKRPEHLRMNL____ R522
p70S6K iso2 (rat) SKRPEHLRMNL____ R499
p70S6K (fruit fly) SPAQDEMMDVQGLPM M482