Other Species / Isoforms
  p70S6K (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S40-p
DQPEDAGsEDELEEG
2 7
p70S6K (human) DQPEDAGsEDELEEG S40-p
p70S6K iso2 (human) DQPEDAGSEDELEEG S17
p70S6K (mouse) DQPEDAGSEDELEEG S40
p70S6K (rat) DQPEDAGsEDELEEG S40-p
p70S6K iso2 (rat) DQPEDAGsEDELEEG S17-p
p70S6K (fruit fly) gap -
S53-p
EGGQLNEsMDHGGVG
Upstream
1 0
Kinase, in vitro:
  • NEK6 (human)
p70S6K (human) EGGQLNEsMDHGGVG S53-p
p70S6K iso2 (human) EGGQLNESMDHGGVG S30
p70S6K (mouse) EGGQLNESMDHGGVG S53
p70S6K (rat) EGGQLNESMDHGGVG S53
p70S6K iso2 (rat) EGGQLNESMDHGGVG S30
p70S6K (fruit fly) gap -
Y62
DHGGVGPYELGMEHC
1 0
p70S6K (human) DHGGVGPYELGMEHC Y62
p70S6K iso2 (human) DHGGVGPYELGMEHC Y39
p70S6K (mouse) DHGGVGPYELGMEHC Y62
p70S6K (rat) DHGGVGPyELGMEHC Y62-p
p70S6K iso2 (rat) DHGGVGPYELGMEHC Y39
p70S6K (fruit fly) gap -
K85-ub
SVNRGPEkIRPECFE
0 1
p70S6K (human) SVNRGPEkIRPECFE K85-ub
p70S6K iso2 (human) SVNRGPEKIRPECFE K62
p70S6K (mouse) SVNRGPEKIRPECFE K85
p70S6K (rat) SVNRGPEKIRPECFE K85
p70S6K iso2 (rat) SVNRGPEKIRPECFE K62
p70S6K (fruit fly) under review -
K104-ub
LGKGGYGkVFQVRKV
0 3
p70S6K (human) LGKGGYGkVFQVRKV K104-ub
p70S6K iso2 (human) LGKGGYGKVFQVRKV K81
p70S6K (mouse) LGKGGYGkVFQVRKV K104-ub
p70S6K (rat) LGKGGYGKVFQVRKV K104
p70S6K iso2 (rat) LGKGGYGKVFQVRKV K81
p70S6K (fruit fly) LGKGGYGKVFQVRKT K90
K118-ub
VTGANTGkIFAMKVL
0 1
p70S6K (human) VTGANTGkIFAMKVL K118-ub
p70S6K iso2 (human) VTGANTGKIFAMKVL K95
p70S6K (mouse) VTGANTGKIFAMkVL K118
p70S6K (rat) VTGANTGKIFAMKVL K118
p70S6K iso2 (rat) VTGANTGKIFAMKVL K95
p70S6K (fruit fly) under review -
K123
TGkIFAMKVLKKAMI
0 1
p70S6K (human) TGkIFAMKVLKKAMI K123
p70S6K iso2 (human) TGKIFAMKVLKKAMI K100
p70S6K (mouse) TGKIFAMkVLkKAMI K123-ac
p70S6K (rat) TGKIFAMKVLKKAMI K123
p70S6K iso2 (rat) TGKIFAMKVLKKAMI K100
p70S6K (fruit fly) ANKYFAMKVLKKASI K109
K126
IFAMKVLKKAMIVRN
0 1
p70S6K (human) IFAMKVLKKAMIVRN K126
p70S6K iso2 (human) IFAMKVLKKAMIVRN K103
p70S6K (mouse) IFAMkVLkKAMIVRN K126-ac
p70S6K (rat) IFAMKVLKKAMIVRN K126
p70S6K iso2 (rat) IFAMKVLKKAMIVRN K103
p70S6K (fruit fly) YFAMKVLKKASIVTN K112
T140
NAKDTAHTKAERNIL
0 1
p70S6K (human) NAKDTAHTKAERNIL T140
p70S6K iso2 (human) NAKDTAHTKAERNIL T117
p70S6K (mouse) NAKDTAHtKAERNIL T140-p
p70S6K (rat) NAKDTAHTKAERNIL T140
p70S6K iso2 (rat) NAKDTAHTKAERNIL T117
p70S6K (fruit fly) NQKDTAHTRAERNIL T126
R217
HQKGIIYRDLKPENI
0 2
p70S6K (human) HQKGIIYRDLKPENI R217
p70S6K iso2 (human) HQKGIIYRDLKPENI R194
p70S6K (mouse) HQKGIIYrDLKPENI R217-m1
p70S6K (rat) HQKGIIYRDLKPENI R217
p70S6K iso2 (rat) HQKGIIYRDLKPENI R194
p70S6K (fruit fly) HKLGIIYRDLKPENI R203
S243-p
DFGLCKEsIHDGtVt
Upstream
0 6
Treatment
  • gefitinib
p70S6K (human) DFGLCKEsIHDGtVt S243-p
p70S6K iso2 (human) DFGLCKESIHDGTVT S220
p70S6K (mouse) DFGLCKEsIHDGtVt S243-p
p70S6K (rat) DFGLCKESIHDGTVT S243
p70S6K iso2 (rat) DFGLCKESIHDGTVT S220
p70S6K (fruit fly) DFGLCKEHIQEGIVT H229
T248-p
KEsIHDGtVtHtFCG
Upstream
0 6
Treatment
  • imatinib
p70S6K (human) KEsIHDGtVtHtFCG T248-p
p70S6K iso2 (human) KESIHDGTVTHtFCG T225
p70S6K (mouse) KEsIHDGtVtHtFCG T248-p
p70S6K (rat) KESIHDGTVTHtFCG T248
p70S6K iso2 (rat) KESIHDGTVTHTFCG T225
p70S6K (fruit fly) KEHIQEGIVTHTFCG I234
T250-p
sIHDGtVtHtFCGtI
Upstream
0 12
Treatment
  • gefitinib
p70S6K (human) sIHDGtVtHtFCGtI T250-p
p70S6K iso2 (human) SIHDGTVTHtFCGTI T227
p70S6K (mouse) sIHDGtVtHtFCGtI T250-p
p70S6K (rat) SIHDGTVTHtFCGTI T250
p70S6K iso2 (rat) SIHDGTVTHTFCGTI T227
p70S6K (fruit fly) HIQEGIVTHTFCGTI T236
T252-p
HDGtVtHtFCGtIEY
Upstream
Downstream
31 19
Effects on Modified Protein
  • enzymatic activity, induced
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • translation, altered
Kinase, in vitro:
  • PDK1 (human)
Putative in vivo kinases:
  • PDK1 (human)
  • PIK3CA (human)
Regulatory protein:
  • TSC1 (mouse)
  • TSC2 (mouse)
  • ULK1 (human)
Treatment
  • EGF
  • EGTA
  • FK506
  • gefitinib
  • IGF-1
  • insulin
  • LY294002
  • medium change
  • methylxanthine
  • OSU-03012
  • peptide inhibitor
  • rapamycin
  • serum
  • wortmannin
p70S6K (human) HDGtVtHtFCGtIEY T252-p
p70S6K iso2 (human) HDGTVTHtFCGTIEY T229-p
p70S6K (mouse) HDGtVtHtFCGtIEY T252-p
p70S6K (rat) HDGTVTHtFCGTIEY T252-p
p70S6K iso2 (rat) HDGTVTHTFCGTIEY T229
p70S6K (fruit fly) QEGIVTHTFCGTIEY T238
T256-p
VtHtFCGtIEYMAPE
Upstream
0 6
Treatment
  • imatinib
p70S6K (human) VtHtFCGtIEYMAPE T256-p
p70S6K iso2 (human) VTHtFCGTIEYMAPE T233
p70S6K (mouse) VtHtFCGtIEYMAPE T256-p
p70S6K (rat) VTHtFCGTIEYMAPE T256
p70S6K iso2 (rat) VTHTFCGTIEYMAPE T233
p70S6K (fruit fly) VTHTFCGTIEYMAPE T242
K304-ac
NRKKTIDkILKCKLN
0 3
p70S6K (human) NRKKTIDkILKCKLN K304-ac
p70S6K iso2 (human) NRKKTIDKILKCKLN K281
p70S6K (mouse) NRKKTIDKILKCKLN K304
p70S6K (rat) NRKKTIDkILKCKLN K304-ac
p70S6K iso2 (rat) NRKKTIDKILKCKLN K281
p70S6K (fruit fly) NRKKTIETILKAKLN T290
K364-ub
WEELLARkVEPPFkP
0 1
p70S6K (human) WEELLARkVEPPFkP K364-ub
p70S6K iso2 (human) WEELLARKVEPPFKP K341
p70S6K (mouse) WEELLARKVEPPFKP K364
p70S6K (rat) WEELLARKVEPPFKP K364
p70S6K iso2 (rat) WEELLARKVEPPFKP K341
p70S6K (fruit fly) WDDVLARRLEPPIKP R350
K370-ub
RkVEPPFkPLLQSEE
0 1
p70S6K (human) RkVEPPFkPLLQSEE K370-ub
p70S6K iso2 (human) RKVEPPFKPLLQSEE K347
p70S6K (mouse) RKVEPPFKPLLQSEE K370
p70S6K (rat) RKVEPPFKPLLQSEE K370
p70S6K iso2 (rat) RKVEPPFKPLLQSEE K347
p70S6K (fruit fly) RRLEPPIKPLLRSED K356
T390-p
DSKFTRQtPVDsPDD
3 14
p70S6K (human) DSKFTRQtPVDsPDD T390-p
p70S6K iso2 (human) DSKFTRQTPVDsPDD T367
p70S6K (mouse) DSKFTRQtPVDsPDD T390-p
p70S6K (rat) DSKFTRQTPVDsPDD T390
p70S6K iso2 (rat) DSKFTRQTPVDSPDD T367
p70S6K (fruit fly) DTRFTRQIPVDSPDD I376
S394-p
TRQtPVDsPDDStLS
Upstream
Downstream
13 14
p70S6K (human)
S394-p
p70S6K (mouse)
S394-p
p70S6K (rat)
S394-p
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • protein conformation
Kinase, in vitro:
  • mTOR (human)
  • mTOR (mouse)
Putative in vivo kinases:
  • CDK1 (human)
  • mTOR (human)
  • PDK1 (human)
Regulatory protein:
  • FOXO1A (human)
  • SESN3 (human)
Treatment
  • insulin
  • osteopontin
  • rapamycin
  • serum
  • wortmannin
p70S6K (human) TRQtPVDsPDDStLS S394-p
p70S6K iso2 (human) TRQTPVDsPDDSTLS S371-p
p70S6K (mouse) TRQtPVDsPDDSTLS S394-p
p70S6K (rat) TRQTPVDsPDDSTLS S394-p
p70S6K iso2 (rat) TRQTPVDSPDDSTLS S371
p70S6K (fruit fly) TRQIPVDSPDDTTLS S380
T399-p
VDsPDDStLSEsANQ
0 1
p70S6K (human) VDsPDDStLSEsANQ T399-p
p70S6K iso2 (human) VDsPDDSTLSESANQ T376
p70S6K (mouse) VDsPDDSTLSESANQ T399
p70S6K (rat) VDsPDDSTLSESANQ T399
p70S6K iso2 (rat) VDSPDDSTLSESANQ T376
p70S6K (fruit fly) VDSPDDTTLSESANL T385
S403-p
DDStLSEsANQVFLG
Upstream
1 2
Kinase, in vitro:
  • NEK6 (human)
p70S6K (human) DDStLSEsANQVFLG S403-p
p70S6K iso2 (human) DDSTLSESANQVFLG S380
p70S6K (mouse) DDSTLSESANQVFLG S403
p70S6K (rat) DDSTLSESANQVFLG S403
p70S6K iso2 (rat) DDSTLSESANQVFLG S380
p70S6K (fruit fly) DDTTLSESANLIFQG S389
T412-p
NQVFLGFtyVAPsVL
Upstream
Downstream
365 9
p70S6K (human)
T412-p
p70S6K iso2 (human)
T389-p
p70S6K (mouse)
T412-p
p70S6K (rat)
T412-p
p70S6K iso2 (rat)
T389-p
p70S6K (fruit fly)
T398-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • phosphorylation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell cycle regulation
  • cell growth, induced
  • translation, altered
  • translation, induced
Kinase, in vitro:
  • mTOR (human)
  • NEK6 (human)
  • PDK1 (human)
Phosphatases, in vitro:
  • PHLPP (human)
  • PHLPP2 (human)
Putative in vivo kinases:
  • mTOR (human)
  • p70S6K (human)
  • PDK1 (human)
  • PIK3CA (human)
Regulatory protein:
  • ACSL4 (human)
  • Akt1 (human)
  • Akt2 (human)
  • AMPKA1 (human)
  • ARL8B (human)
  • ATG13 (human)
  • CIP2A (human)
  • CK1E (human)
  • DDIT4 (human)
  • DDIT4L (human)
  • DDX48 (human)
  • DUSP6 (human)
  • DYRK3 (human)
  • FAK (human)
  • FLCN (human)
  • FOXO1A (human)
  • FRS2 (human)
  • GSK3A (human)
  • GSK3B (human)
  • HERC1 (human)
  • HRas (human)
  • KHS2 (human)
  • LAMTOR1 (human)
  • LAMTOR2 (human)
  • LAMTOR3 (human)
  • LST8 (human)
  • MAGE-A6 (human)
  • MAGEA3 (human)
  • MKK6 (human)
  • Mnk1 (human)
  • mTOR (human)
  • Notch 1 (human)
  • OSBPL9 (human)
  • p27Kip1 (human)
  • p70S6K (human)
  • PIK3C2B (human)
  • PKCA (human)
  • PKM (human)
  • PKM iso2 (human)
  • PLK1 (human)
  • PPP1CC (human)
  • PPP2CA (human)
  • PRAS40 (human)
  • PRAS40 iso3 (human)
  • PRKD1 (human)
  • RAF1 (human)
  • RAG1 (human)
  • Raptor (human)
  • Ret (human)
  • RHEB (human)
  • RICTOR (human)
  • RMP (human)
  • RRAGA (human)
  • RRAGB (human)
  • Sin1 (human)
  • SKAR (human)
  • SLC1A5 (human)
  • SLC3A2 (human)
  • SLC7A5 (human)
  • SMPD3 (human)
  • SPRY2 (human)
  • TRAF2 (human)
  • TRAF4 (human)
  • TSC1 (human)
  • TSC1 (mouse)
  • TSC2 (human)
  • TSC2 (mouse)
  • ULK1 (human)
  • ULK2 (human)
Treatment
  • 1,25_dihydroxyvitamin_D
  • 1,25D
  • 1-azakenpaullone
  • 2-deoxyglucose
  • 3-Methyladenine
  • 5(S)-HETE
  • 5-cholesten-5-beta-ol
  • 8-CPT-2Me-cAMP
  • A-443654
  • acadesine
  • AG1024
  • AG1296
  • AG1478
  • AG490
  • alpelisib
  • ALW-II-41-27
  • amino_acid_starvation
  • amino_acids
  • angiotensin
  • anisomycin
  • anti-HLA
  • anti-ITGB1
  • anti-ITGB3
  • anti-TNFalpha
  • apelin
  • APV
  • AR-A014418
  • aspirin
  • ATP
  • AZD8055
  • bisindolylmaleimide
  • blood pressure
  • calyculin_A
  • carbachol
  • Cbz-B3A
  • CGP57380
  • cholesterol_oxidase
  • colforsin
  • compound_C
  • cycloheximide
  • dactolisib
  • DAMGO
  • depolarization
  • dexamethasone
  • dinoprost
  • EGF
  • ephrin_A1
  • Epo
  • erlotinib
  • estradiol
  • ethanol
  • exercise
  • FCCP
  • FGF1
  • FGF2
  • fibronectin
  • Filipin
  • fingolimod
  • FK506
  • fluoromethylketone
  • GDNF
  • GF109203X
  • glucose
  • glucose_starvation
  • glutamic acid
  • GM-CSF
  • Go_6796
  • GSK-626616
  • H2O2
  • herbimycin_A
  • heregulin
  • IFN-gamma
  • IGF-1
  • IL-6
  • imatinib
  • indometacin
  • INK-128
  • insulin
  • ionizing_radiation
  • ionomycin
  • itraconazol
  • JQ1
  • kb_NB_142-70
  • KP-372-1
  • KP-372-2
  • KU-0063794
  • L-744,832
  • laminar flow
  • leucine_deprivation
  • liothyronine
  • long-term_potentiation
  • LPS
  • LY294002
  • meal feeding
  • medium change
  • metformin
  • methyl-beta-cyclodextrin
  • methylxanthine
  • mifepristone
  • miR-451
  • MK-2206
  • monensin
  • monodansylcadaverine
  • naloxone
  • NBQX
  • nifedipine
  • nilotinib
  • nitric_oxide
  • NMDA
  • nocodazole
  • okadaic_acid
  • oscillatory_flow
  • osteopontin
  • paracetamol
  • PD98059
  • pemetrexed
  • peptide inhibitor
  • PF-670462
  • phorbol_ester
  • PI-103
  • picropodophyllin
  • pimenta doica
  • PKC_inhibitor_myristoylated
  • PKI-402
  • PP1
  • PP2
  • PP242
  • PTX
  • QLT0254
  • RAD001
  • rapamycin
  • resveratrol
  • retinoic_acid
  • RGD
  • rosiglitazone
  • rottlerin
  • salicylate
  • SB202190
  • SB203580
  • SB216763
  • SCF
  • seocalcitol
  • serum
  • serum_starvation
  • serum_withdrawal
  • SGI-1776
  • SH-6
  • sildenafil
  • silmitasertib
  • simvastatin
  • siRNA
  • sorafenib
  • sorbitol
  • SP600125
  • sphingosine_1-phosphate
  • taxol
  • temsirolimus
  • thapsigargin
  • tioguanine
  • Torin1
  • U0126
  • UV
  • vanadate
  • virus infection
  • wortmannin
  • WYE132
  • Zn(2+)
p70S6K (human) NQVFLGFtyVAPsVL T412-p
p70S6K iso2 (human) NQVFLGFtYVAPSVL T389-p
p70S6K (mouse) NQVFLGFtYVAPSVL T412-p
p70S6K (rat) NQVFLGFtYVAPSVL T412-p
p70S6K iso2 (rat) NQVFLGFtYVAPSVL T389-p
p70S6K (fruit fly) NLIFQGFTYVAPSIL T398
Y413-p
QVFLGFtyVAPsVLE
0 2
p70S6K (human) QVFLGFtyVAPsVLE Y413-p
p70S6K iso2 (human) QVFLGFtYVAPSVLE Y390
p70S6K (mouse) QVFLGFtYVAPSVLE Y413
p70S6K (rat) QVFLGFtYVAPSVLE Y413
p70S6K iso2 (rat) QVFLGFtYVAPSVLE Y390
p70S6K (fruit fly) LIFQGFTYVAPSILE Y399
S417-p
GFtyVAPsVLEsVKE
0 1
p70S6K (human) GFtyVAPsVLEsVKE S417-p
p70S6K iso2 (human) GFtYVAPSVLESVKE S394
p70S6K (mouse) GFtYVAPSVLESVKE S417
p70S6K (rat) GFtYVAPSVLESVKE S417
p70S6K iso2 (rat) GFtYVAPSVLESVKE S394
p70S6K (fruit fly) GFTYVAPSILEDMHR S403
S421-p
VAPsVLEsVKEkFsF
0 2
p70S6K (human) VAPsVLEsVKEkFsF S421-p
p70S6K iso2 (human) VAPSVLESVKEKFSF S398
p70S6K (mouse) VAPSVLESVKEKFsF S421
p70S6K (rat) VAPSVLESVKEKFSF S421
p70S6K iso2 (rat) VAPSVLESVKEKFSF S398
p70S6K (fruit fly) VAPSILEDMHRANRM D407
K425-ub
VLEsVKEkFsFEPKI
0 1
p70S6K (human) VLEsVKEkFsFEPKI K425-ub
p70S6K iso2 (human) VLESVKEKFSFEPKI K402
p70S6K (mouse) VLESVKEKFsFEPKI K425
p70S6K (rat) VLESVKEKFSFEPKI K425
p70S6K iso2 (rat) VLESVKEKFSFEPKI K402
p70S6K (fruit fly) under review -
S427-p
EsVKEkFsFEPKIRs
Upstream
Downstream
5 12
Effects on Modified Protein
  • enzymatic activity, induced
Treatment
  • EGTA
  • FK506
  • ischemia
  • methylxanthine
  • rapamycin
  • serum
  • vemurafenib
  • wortmannin
p70S6K (human) EsVKEkFsFEPKIRs S427-p
p70S6K iso2 (human) ESVKEKFSFEPKIRS S404
p70S6K (mouse) ESVKEKFsFEPKIRs S427-p
p70S6K (rat) ESVKEKFSFEPKIRs S427
p70S6K iso2 (rat) ESVKEKFSFEPKIRS S404
p70S6K (fruit fly) EDMHRANRMPARSPR R413
S434-p
sFEPKIRsPRRFIGs
Upstream
Downstream
27 1
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (human)
  • ERK2 (mouse)
  • JNK1 (mouse)
  • JNK2 (mouse)
Putative in vivo kinases:
  • CDK1 (human)
  • mTOR (human)
Regulatory protein:
  • FRS2 (human)
  • TSC1 (mouse)
  • TSC2 (mouse)
Treatment
  • bisindolylmaleimide
  • EGF
  • EGTA
  • FGF1
  • FK506
  • heregulin
  • IGF-1
  • IL-6
  • insulin
  • LY294002
  • methylxanthine
  • nocodazole
  • PD98059
  • phorbol_ester
  • purvalanol
  • rapamycin
  • SB202190
  • seliciclib
  • serum
  • taxol
  • U0126
  • UV
  • vanadate
  • wortmannin
p70S6K (human) sFEPKIRsPRRFIGs S434-p
p70S6K iso2 (human) SFEPKIRSPRRFIGs S411
p70S6K (mouse) sFEPKIRsPRRFIGs S434-p
p70S6K (rat) SFEPKIRsPRRFIGs S434-p
p70S6K iso2 (rat) SFEPKIRSPRRFIGS S411
p70S6K (fruit fly) ANRMPARSPRRTPRQ S418
S441-p
sPRRFIGsPRtPVsP
Upstream
Downstream
9 117
Effects on Modified Protein
  • enzymatic activity, induced
Treatment
  • angiotensin_2
  • EGF
  • EGTA
  • ischemia
  • methylxanthine
  • nocodazole
  • rapamycin
  • SB202190
  • serum
  • SII_angiotensin_2
  • wortmannin
p70S6K (human) sPRRFIGsPRtPVsP S441-p
p70S6K iso2 (human) SPRRFIGsPRtPVsP S418-p
p70S6K (mouse) sPRRFIGsPRtPVsP S441-p
p70S6K (rat) sPRRFIGsPRtPVsP S441-p
p70S6K iso2 (rat) SPRRFIGSPRtPVsP S418
p70S6K (fruit fly) SPRRTPRQLPDSSFR Q425
T444-p
RFIGsPRtPVsPVkF
Upstream
Downstream
101 139
p70S6K (human)
T444-p
p70S6K (mouse)
T444-p
p70S6K (rat)
T444-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell cycle regulation
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (human)
  • TBK1 (human)
Regulatory protein:
  • DDIT4 (human)
  • DDIT4L (human)
  • DUSP6 (human)
  • FAK (human)
  • FRS2 (human)
  • LKB1 (human)
  • mTOR (human)
  • PIK3R1 (human)
  • PIK3R2 (human)
  • RAF1 (human)
  • SHIP (human)
  • TBK1 (human)
  • TSC2 (human)
Treatment
  • 1,25D
  • 1-butanol
  • 5-cholesten-5-beta-ol
  • actinomycin_D
  • AEE788
  • AG1478
  • angiotensin_2
  • anti-CD3
  • anti-HLA
  • anti-ITGA5
  • anti-ITGB1
  • anti-ITGB3
  • apelin
  • As2O3
  • BAPTA-AM
  • bisindolylmaleimide
  • blood pressure
  • cholesterol_oxidase
  • colforsin
  • cycloheximide
  • DAMGO
  • dexamethasone
  • dinoprost
  • EGF
  • EGTA
  • exercise
  • FGF1
  • fibronectin
  • Filipin
  • fingolimod
  • FK506
  • GF109203X
  • glucose
  • GM-CSF
  • H2O2
  • herbimycin_A
  • heregulin
  • histamine
  • hypertonic_buffer
  • IFN-alpha
  • IFN-beta
  • IFN-gamma
  • IGF-1
  • IL-6
  • imatinib
  • insulin
  • ionizing_radiation
  • ischemia
  • LY294002
  • mepyramine
  • methyl-beta-cyclodextrin
  • methylxanthine
  • monensin
  • monodansylcadaverine
  • naloxone
  • nocodazole
  • osteopontin
  • PD184352
  • PD90059
  • PD98059
  • PDGF
  • phorbol_ester
  • pictilisib
  • PKC_inhibitor_myristoylated
  • PP1
  • PP2
  • PTX
  • purvalanol
  • RAD001
  • rapamycin
  • retinoic_acid
  • RGD
  • Ro31-8425
  • rosiglitazone
  • SB202190
  • SB203580
  • SCF
  • seliciclib
  • serum
  • SH-6
  • SII_angiotensin_2
  • simvastatin
  • siRNA
  • SP600125
  • t-butanol
  • taxol
  • thioperamide
  • thrombin
  • tiotidine
  • U0126
  • U73122
  • UV
  • vanadate
  • wortmannin
  • Zn(2+)
p70S6K (human) RFIGsPRtPVsPVkF T444-p
p70S6K iso2 (human) RFIGsPRtPVsPVKF T421-p
p70S6K (mouse) RFIGsPRtPVsPVKF T444-p
p70S6K (rat) RFIGsPRtPVsPVKF T444-p
p70S6K iso2 (rat) RFIGSPRtPVsPVKF T421-p
p70S6K (fruit fly) TPRQLPDSSFRLQFP S429
S447-p
GsPRtPVsPVkFsPG
Upstream
Downstream
96 290
p70S6K (human)
S447-p
p70S6K (mouse)
S447-p
p70S6K (rat)
S447-p
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell adhesion, altered
  • cell cycle regulation
Kinase, in vitro:
  • ERK1 (mouse)
  • ERK2 (human)
  • TBK1 (human)
Putative in vivo kinases:
  • CDK1 (human)
Regulatory protein:
  • DDIT4 (human)
  • DDIT4L (human)
  • DUSP6 (human)
  • FAK (human)
  • FRS2 (human)
  • mTOR (human)
  • PIK3R1 (human)
  • PIK3R2 (human)
  • RAF1 (human)
  • SHIP (human)
  • TBK1 (human)
  • TSC2 (human)
Treatment
  • 1,25D
  • 1-butanol
  • 2-deoxyglucose
  • 5-cholesten-5-beta-ol
  • actinomycin_D
  • AEE788
  • AG1478
  • angiotensin_2
  • anti-CD3
  • anti-HLA
  • anti-ITGA5
  • anti-ITGB1
  • anti-ITGB3
  • apelin
  • As2O3
  • BAPTA-AM
  • bisindolylmaleimide
  • blood pressure
  • cholesterol_oxidase
  • colforsin
  • cycloheximide
  • DAMGO
  • dexamethasone
  • EGF
  • EGTA
  • exercise
  • FGF1
  • fibronectin
  • Filipin
  • fingolimod
  • FK506
  • GF109203X
  • glucose
  • GM-CSF
  • H2O2
  • herbimycin_A
  • heregulin
  • histamine
  • hypertonic_buffer
  • IFN-alpha
  • IFN-beta
  • IFN-gamma
  • IGF-1
  • IL-6
  • imatinib
  • insulin
  • ionizing_radiation
  • ischemia
  • LY294002
  • mepyramine
  • methyl-beta-cyclodextrin
  • methylxanthine
  • monensin
  • monodansylcadaverine
  • naloxone
  • nocodazole
  • osteopontin
  • PD184352
  • PD90059
  • PD98059
  • PDGF
  • phorbol_ester
  • PKC_inhibitor_myristoylated
  • PP1
  • PP2
  • PTX
  • purvalanol
  • RAD001
  • rapamycin
  • RGD
  • Ro31-8425
  • rosiglitazone
  • SB202190
  • SB203580
  • SCF
  • seliciclib
  • serum
  • SH-6
  • SII_angiotensin_2
  • simvastatin
  • siRNA
  • SP600125
  • t-butanol
  • taxol
  • thioperamide
  • thrombin
  • tiotidine
  • Torin1
  • U0126
  • U73122
  • UV
  • vanadate
  • wortmannin
  • Zn(2+)
p70S6K (human) GsPRtPVsPVkFsPG S447-p
p70S6K iso2 (human) GsPRtPVsPVKFSPG S424-p
p70S6K (mouse) GsPRtPVsPVKFsPG S447-p
p70S6K (rat) GsPRtPVsPVKFsPG S447-p
p70S6K iso2 (rat) GSPRtPVsPVKFSPG S424-p
p70S6K (fruit fly) PRQLPDSSFRLQFPS S430
K450-ub
RtPVsPVkFsPGDFW
0 1
p70S6K (human) RtPVsPVkFsPGDFW K450-ub
p70S6K iso2 (human) RtPVsPVKFSPGDFW K427
p70S6K (mouse) RtPVsPVKFsPGDFW K450
p70S6K (rat) RtPVsPVKFsPGDFW K450
p70S6K iso2 (rat) RtPVsPVKFSPGDFW K427
p70S6K (fruit fly) under review -
S452-p
PVsPVkFsPGDFWGR
Upstream
1 97
Treatment
  • nocodazole
  • rapamycin
  • Torin1
p70S6K (human) PVsPVkFsPGDFWGR S452-p
p70S6K iso2 (human) PVsPVKFSPGDFWGR S429
p70S6K (mouse) PVsPVKFsPGDFWGR S452-p
p70S6K (rat) PVsPVKFsPGDFWGR S452-p
p70S6K iso2 (rat) PVsPVKFSPGDFWGR S429
p70S6K (fruit fly) SFRLQFPSANVGANA S437
S462-p
DFWGRGAsASTANPQ
0 1
p70S6K (human) DFWGRGAsASTANPQ S462-p
p70S6K iso2 (human) DFWGRGASASTANPQ S439
p70S6K (mouse) DFWGRGASASTANPQ S462
p70S6K (rat) DFWGRGASASTANPQ S462
p70S6K iso2 (rat) DFWGRGASASTANPQ S439
p70S6K (fruit fly) gap -
T470-p
ASTANPQtPVEYPME
1 0
p70S6K (human) ASTANPQtPVEYPME T470-p
p70S6K iso2 (human) ASTANPQTPVEYPME T447
p70S6K (mouse) ASTANPQTPVEYPME T470
p70S6K (rat) ASTANPQTPVEYPME T470
p70S6K iso2 (rat) ASTANPQTPVEYPME T447
p70S6K (fruit fly) gap -
K507
QPNSGPYKKQAFPMI
2 0
p70S6K (human) QPNSGPYKKQAFPMI K507
p70S6K iso2 (human) QPNSGPYkkQAFPMI K484-ac
p70S6K (mouse) QPNSGPYkkQAFPMI K507-ac
p70S6K (rat) QPNSGPYKKQAFPMI K507
p70S6K iso2 (rat) QPNSGPYKKQAFPMI K484
p70S6K (fruit fly) gap -
K508
PNSGPYKKQAFPMIS
2 0
p70S6K (human) PNSGPYKKQAFPMIS K508
p70S6K iso2 (human) PNSGPYkkQAFPMIS K485-ac
p70S6K (mouse) PNSGPYkkQAFPMIS K508-ac
p70S6K (rat) PNSGPYKKQAFPMIS K508
p70S6K iso2 (rat) PNSGPYKKQAFPMIS K485
p70S6K (fruit fly) gap -
K516-ac
QAFPMISkRPEHLrM
Upstream
3 0
Treatment
  • IGF-1
  • insulin
  • serum
p70S6K (human) QAFPMISkRPEHLrM K516-ac
p70S6K iso2 (human) QAFPMISkRPEHLRM K493-ac
p70S6K (mouse) QAFPMISkRPEHLRM K516-ac
p70S6K (rat) QAFPMISKRPEHLRM K516
p70S6K iso2 (rat) QAFPMISKRPEHLRM K493
p70S6K (fruit fly) gap -
R522-m1
SkRPEHLrMNL____
0 1
p70S6K (human) SkRPEHLrMNL____ R522-m1
p70S6K iso2 (human) SkRPEHLRMNL____ R499
p70S6K (mouse) SkRPEHLRMNL____ R522
p70S6K (rat) SKRPEHLRMNL____ R522
p70S6K iso2 (rat) SKRPEHLRMNL____ R499
p70S6K (fruit fly) gap -