Other Species / Isoforms
  MSK1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T38-p
ELRTANLtGHAEKVG
Upstream
0 3
Treatment
  • ischemia
MSK1 (human) ELRTANLtGHAEKVG T38-p
MSK1 (mouse) ELRTANLtGHAEKVG T37-p
MSK1 (rat) ELRTANLTGHAEKVG T37
K53-ub
IENFELLkVLGTGAy
0 1
MSK1 (human) IENFELLkVLGTGAy K53-ub
MSK1 (mouse) IENFELLKVLGTGAY K52
MSK1 (rat) IENFELLKVLGTGAY K52
Y60-p
kVLGTGAyGKVFLVR
0 1
MSK1 (human) kVLGTGAyGKVFLVR Y60-p
MSK1 (mouse) KVLGTGAYGKVFLVR Y59
MSK1 (rat) KVLGTGAYGKVFLVR Y59
Y175-p
LHKLGIIyRDIKLEN
0 1
MSK1 (human) LHKLGIIyRDIKLEN Y175-p
MSK1 (mouse) LHKLGIIYRDIKLEN Y174
MSK1 (rat) LHKLGIIYRDIKLEN Y174
S199-p
VLTDFGLsKEFVADE
0 2
MSK1 (human) VLTDFGLsKEFVADE S199-p
MSK1 (mouse) VLTDFGLsKEFVADE S198-p
MSK1 (rat) VLTDFGLSKEFVADE S198
S212-p
DETERAYsFCGTIEY
Upstream
Downstream
2 14
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
Treatment
  • ischemia
  • PD184352
  • phorbol_ester
  • SB203580
  • UV
MSK1 (human) DETERAYsFCGTIEY S212-p
MSK1 (mouse) DETERAYsFCGTIEY S211-p
MSK1 (rat) DEAERAYSFCGTIEY S211
S240-p
DKAVDWWsLGVLMYE
0 1
MSK1 (human) DKAVDWWsLGVLMYE S240-p
MSK1 (mouse) DKAVDWWSLGVLMYE S239
MSK1 (rat) gap -
S253-p
YELLTGAsPFTVDGE
0 1
MSK1 (human) YELLTGAsPFTVDGE S253-p
MSK1 (mouse) YELLTGASPFTVDGE S252
MSK1 (rat) gap -
S268-p
KNSQAEIsRRILkSE
0 1
MSK1 (human) KNSQAEIsRRILkSE S268-p
MSK1 (mouse) KNSQAEISRRILKSE S267
MSK1 (rat) gap -
K273-ub
EIsRRILkSEPPYPQ
0 1
MSK1 (human) EIsRRILkSEPPYPQ K273-ub
MSK1 (mouse) EISRRILKSEPPYPQ K272
MSK1 (rat) under review -
K313-ub
PRDADEIkEHLFFQK
0 1
MSK1 (human) PRDADEIkEHLFFQK K313-ub
MSK1 (mouse) PRDAEEIKEHLFFEK K312
MSK1 (rat) PRDAEEIKEHLFFEK K266
K329-ub
NWDDLAAkKVPAPFK
0 1
MSK1 (human) NWDDLAAkKVPAPFK K329-ub
MSK1 (mouse) KWDDLAAKKVPAPFK K328
MSK1 (rat) NWDDLAAKKVPAPFK K282
S346
IRDELDVSNFAEEFT
0 2
MSK1 (human) IRDELDVSNFAEEFT S346
MSK1 (mouse) IRDELDVsNFAEEFT S345-p
MSK1 (rat) IRDELDVSNFAEEFT S299
S360-p
TEMDPTYsPAALPQS
Upstream
Downstream
5 16
MSK1 (human)
S360-p
Effects on Modified Protein
  • enzymatic activity, induced
  • protein conformation
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
  • P38A (human)
Treatment
  • PD184352
  • phorbol_ester
  • SB203580
  • UV
MSK1 (human) TEMDPTYsPAALPQS S360-p
MSK1 (mouse) TEMDPTYsPAALPQS S359-p
MSK1 (rat) TEMDPTYSPAALPQS S313
Y375-p
SEKLFQGysFVAPsI
0 7
MSK1 (human) SEKLFQGysFVAPsI Y375-p
MSK1 (mouse) SERLFQGysFVAPsI Y374-p
MSK1 (rat) SERLFQGYsFVAPsI Y328
S376-p
EKLFQGysFVAPsIL
Upstream
Downstream
21 59
MSK1 (human)
S376-p
MSK1 (mouse)
S375-p
Effects on Modified Protein
  • enzymatic activity, induced
Kinase, in vitro:
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
Treatment
  • angiotensin_2
  • culturing_of_cells
  • dimethylfumarate
  • EGF
  • farnesol
  • fluid_shear_stress
  • fumaric_acid
  • genistein
  • IFN-alpha
  • IL-1b
  • ischemia
  • ischemia/reperfusion
  • LY294002
  • methylhydrogenfumarate
  • PD184352
  • PD98059
  • phorbol_ester
  • SB202190
  • SB203580
  • SII_angiotensin_2
  • SP600125
  • U0126
  • UV
  • vanadate
  • VEGF
MSK1 (human) EKLFQGysFVAPsIL S376-p
MSK1 (mouse) ERLFQGysFVAPsIL S375-p
MSK1 (rat) ERLFQGYsFVAPsIL S329-p
S381-p
GysFVAPsILFkRNA
Upstream
2 23
Kinase, in vitro:
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
Treatment
  • angiotensin_2
  • EGF
  • PD184352
  • phorbol_ester
  • SB202190
  • SB203580
  • SII_angiotensin_2
  • U0126
  • UV
MSK1 (human) GysFVAPsILFkRNA S381-p
MSK1 (mouse) GysFVAPsILFKRNA S380-p
MSK1 (rat) GYsFVAPsILFKRNA S334-p
K385-ub
VAPsILFkRNAAVID
0 1
MSK1 (human) VAPsILFkRNAAVID K385-ub
MSK1 (mouse) VAPsILFKRNAAVID K384
MSK1 (rat) VAPsILFKRNAAVID K338
S436-p
DKPLGEGsFSICRKC
0 1
MSK1 (human) DKPLGEGsFSICRKC S436-p
MSK1 (mouse) DKPLGEGSFSICRKC S435
MSK1 (rat) DKPLGEGSFSICRKC S389
S448-p
RKCVHKKsNQAFAVK
0 1
MSK1 (human) RKCVHKKsNQAFAVK S448-p
MSK1 (mouse) RKCVHKKTNQAFAVK T447
MSK1 (rat) RKCVHKKTNQAFAVK T401
K473-ub
QKEITALkLCEGHPN
0 1
MSK1 (human) QKEITALkLCEGHPN K473-ub
MSK1 (mouse) QKEITALKLCEGHPN K472
MSK1 (rat) QKEITALKLCEGHPN K426
K527-ub
EASYIMRkLVSAVSH
0 1
MSK1 (human) EASYIMRkLVSAVSH K527-ub
MSK1 (mouse) EASYIMRKLVSAVSH K591
MSK1 (rat) EASYIMRKLVSAVSH K480
K546-ub
GVVHRDLkPENLLFT
0 1
MSK1 (human) GVVHRDLkPENLLFT K546-ub
MSK1 (mouse) GVVHRDLKPENLLFT K610
MSK1 (rat) GVVHRDLKPETVFHR K499
T581-p
PDNQPLKtPCFTLHY
Upstream
Downstream
14 1
MSK1 (human)
T581-p
MSK1 (mouse)
T645-p
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
Effects on Biological Processes:
  • cell growth, induced
  • cytoskeletal reorganization
  • transcription, induced
Putative in vivo kinases:
  • ERK1 (human)
  • ERK2 (human)
  • P38A (human)
Regulatory protein:
  • LMP1 (herpesvirus)
  • TNF-R1 (human)
  • TNF-R2 (human)
Treatment
  • 8-Rp-cAMP
  • AACOCF3
  • anti-TNFR1
  • anti-TNFR2
  • electrical_stimulation
  • FGF9
  • H-89
  • IFN-alpha
  • PD184352
  • PD98059
  • phenylephrine
  • phorbol_ester
  • Ro31-8220
  • SB203580
  • TNF
  • UV
  • zinterol
MSK1 (human) PDNQPLKtPCFTLHY T581-p
MSK1 (mouse) PDNQPLKtPCFTLHY T645-p
MSK1 (rat) gap -
S628-p
PFQSHDRsLTCTSAV
0 1
MSK1 (human) PFQSHDRsLTCTSAV S628-p
MSK1 (mouse) PFQSHDRSLtCTSAV S692
MSK1 (rat) gap -
T630
QSHDRsLTCTSAVEI
1 1
MSK1 (human) QSHDRsLTCTSAVEI T630
MSK1 (mouse) QSHDRSLtCTSAVEI T694-p
MSK1 (rat) gap -
S647
KIKKGDFSFEGEAWk
1 1
MSK1 (human) KIKKGDFSFEGEAWk S647
MSK1 (mouse) KIKKGDFsFEGEAWK S711-p
MSK1 (rat) gap -
K654-ub
SFEGEAWkNVSQEAk
0 1
MSK1 (human) SFEGEAWkNVSQEAk K654-ub
MSK1 (mouse) sFEGEAWKNVsQEAK K718
MSK1 (rat) under review -
S657
GEAWkNVSQEAkDLI
1 1
MSK1 (human) GEAWkNVSQEAkDLI S657
MSK1 (mouse) GEAWKNVsQEAKDLI S721-p
MSK1 (rat) gap -
K661-ub
kNVSQEAkDLIQGLL
0 1
MSK1 (human) kNVSQEAkDLIQGLL K661-ub
MSK1 (mouse) KNVsQEAKDLIQGLL K725
MSK1 (rat) under review -
K674-ub
LLTVDPNkRLkMSGL
0 1
MSK1 (human) LLTVDPNkRLkMSGL K674-ub
MSK1 (mouse) LLTVDPNKRLKMSGL K738
MSK1 (rat) under review -
K677-ub
VDPNkRLkMSGLRyN
0 1
MSK1 (human) VDPNkRLkMSGLRyN K677-ub
MSK1 (mouse) VDPNKRLKMSGLRYN K741
MSK1 (rat) under review -
Y683-p
LkMSGLRyNEWLQDG
0 1
MSK1 (human) LkMSGLRyNEWLQDG Y683-p
MSK1 (mouse) LKMSGLRYNEWLQDG Y747
MSK1 (rat) gap -
S691-p
NEWLQDGsQLssNPL
0 14
MSK1 (human) NEWLQDGsQLssNPL S691-p
MSK1 (mouse) NEWLQDGsQLssNPL S755-p
MSK1 (rat) gap -
S694-p
LQDGsQLssNPLMtP
0 10
MSK1 (human) LQDGsQLssNPLMtP S694-p
MSK1 (mouse) LQDGsQLssNPLMtP S758-p
MSK1 (rat) gap -
S695-p
QDGsQLssNPLMtPD
1 7
MSK1 (human) QDGsQLssNPLMtPD S695-p
MSK1 (mouse) QDGsQLssNPLMtPD S759-p
MSK1 (rat) gap -
T700-p
LssNPLMtPDILGSS
1 20
MSK1 (human) LssNPLMtPDILGSS T700-p
MSK1 (mouse) LssNPLMtPDILGSS T764-p
MSK1 (rat) gap -
S750-p
RRKMKKTstsTETRs
Upstream
2 3
Kinase, in vitro:
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
Treatment
  • PD184352
  • phorbol_ester
  • SB203580
  • UV
MSK1 (human) RRKMKKTstsTETRs S750-p
MSK1 (mouse) RRKMKRTstsTETRS S814-p
MSK1 (rat) gap -
T751-p
RKMKKTstsTETRss
0 2
MSK1 (human) RKMKKTstsTETRss T751-p
MSK1 (mouse) RKMKRTstsTETRSS T815-p
MSK1 (rat) gap -
S752-p
KMKKTstsTETRsss
Upstream
2 1
Kinase, in vitro:
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
Treatment
  • PD184352
  • phorbol_ester
  • SB203580
  • UV
MSK1 (human) KMKKTstsTETRsss S752-p
MSK1 (mouse) KMKRTstsTETRSSS S816-p
MSK1 (rat) gap -
S757-p
stsTETRssssESSH
Upstream
0 1
Kinase, in vitro:
  • CK2A1 (human)
MSK1 (human) stsTETRssssESSH S757-p
MSK1 (mouse) stsTETRSSSSESSR S821
MSK1 (rat) gap -
S758-p
tsTETRssssESSHS
Upstream
1 2
Kinase, in vitro:
  • CK2A1 (human)
  • MSK1 (human)
Putative in vivo kinases:
  • MSK1 (human)
MSK1 (human) tsTETRssssESSHS S758-p
MSK1 (mouse) tsTETRSSSSESSRS S822
MSK1 (rat) gap -
S759-p
sTETRssssESSHSs
Upstream
0 2
Kinase, in vitro:
  • CK2A1 (human)
MSK1 (human) sTETRssssESSHSs S759-p
MSK1 (mouse) sTETRSSSSESSRSS S823
MSK1 (rat) gap -
S760-p
TETRssssESSHSsS
Upstream
0 2
Kinase, in vitro:
  • CK2A1 (human)
MSK1 (human) TETRssssESSHSsS S760-p
MSK1 (mouse) TETRSSSSESSRSSS S824
MSK1 (rat) gap -
S766-p
ssESSHSsSSHsHGK
0 1
MSK1 (human) ssESSHSsSSHsHGK S766-p
MSK1 (mouse) SSESSRSSSSQsHGK S830
MSK1 (rat) gap -
S770-p
SHSsSSHsHGKTTPT
0 2
MSK1 (human) SHSsSSHsHGKTTPT S770-p
MSK1 (mouse) SRSSSSQsHGKTTPt S834-p
MSK1 (rat) gap -
T777
sHGKTTPTKTLQPSN
0 1
MSK1 (human) sHGKTTPTKTLQPSN T777
MSK1 (mouse) sHGKTTPtKTLQPSN T841-p
MSK1 (rat) gap -
T793-p
ADSNNPEtLFQFSDS
Upstream
0 1
Kinase, in vitro:
  • CK2A1 (human)
MSK1 (human) ADSNNPEtLFQFSDS T793-p
MSK1 (mouse) TEGSNPDTLFQFsD_ T857
MSK1 (rat) gap -
S798
PEtLFQFSDSVA___
0 6
MSK1 (human) PEtLFQFSDSVA___ S798
MSK1 (mouse) PDTLFQFsD______ S862-p
MSK1 (rat) gap -