Other Species / Isoforms
  MLK3 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S11-p
LKSLFLKsPLGSWNG
0 3
MLK3 (human) LKSLFLKsPLGSWNG S11-p
MLK3 (mouse) LKNLFLKSPLGSWNG S11
MLK3 (rat) LKNLFLKSPLGSWNG S11
MLK3 (cow) LKNLFLKSPLGSWNS S11
S35-p
GGGRPEGsPKAAGYA
0 8
MLK3 (human) GGGRPEGsPKAAGYA S35-p
MLK3 (mouse) GGVRPEGsPKATAAY S35-p
MLK3 (rat) GGVRPEGSPKATAAY S35
MLK3 (cow) GGGWPEGSPKAAAYA S35
K261-ub
ESDDMEHkTLkITDF
0 1
MLK3 (human) ESDDMEHkTLkITDF K261-ub
MLK3 (mouse) EGDDMEHKTLKITDF K262
MLK3 (rat) EGDDMEHKTLKITDF K262
MLK3 (cow) EGDDMEHKTLKITDF K261
K264-ub
DMEHkTLkITDFGLA
1 1
MLK3 (human) DMEHkTLkITDFGLA K264-ub
MLK3 (mouse) DMEHKTLKITDFGLA K265
MLK3 (rat) DMEHKTLKITDFGLA K265
MLK3 (cow) DMEHKTLKITDFGLA K264
T277-p
LAREWHKtTQMsAAG
Upstream
Downstream
6 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell differentiation, induced
Kinase, in vitro:
  • MLK3 (human)
Treatment
  • carbachol
  • ischemia/reperfusion
  • vanadate
MLK3 (human) LAREWHKtTQMsAAG T277-p
MLK3 (mouse) LAREWHKtTQMsAAG T278-p
MLK3 (rat) LAREWHKTTQMSAAG T278
MLK3 (cow) LAREWHKTTQMSAAG T277
S281-p
WHKtTQMsAAGTYAW
Upstream
Downstream
6 0
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Effects on Biological Processes:
  • cell differentiation, induced
Kinase, in vitro:
  • HPK1 (human)
  • MLK3 (human)
Treatment
  • carbachol
  • ischemia/reperfusion
  • vanadate
MLK3 (human) WHKtTQMsAAGTYAW S281-p
MLK3 (mouse) WHKtTQMsAAGTYAW S282-p
MLK3 (rat) WHKTTQMSAAGTYAW S282
MLK3 (cow) WHKTTQMSAAGTYAW S281
S394-p
MPRDSFHsMQEGWKR
0 2
MLK3 (human) MPRDSFHsMQEGWKR S394-p
MLK3 (mouse) MPRDSFHsMQEGWKR S395-p
MLK3 (rat) MPRDSFHSMQEGWKR S395
MLK3 (cow) MPRDSFHSMQEGWKR S394
T477-p
HVRRRRGtFKRSKLR
Upstream
1 0
Treatment
  • insulin
MLK3 (human) HVRRRRGtFKRSKLR T477-p
MLK3 (mouse) HVRRRRGTFKRSKLR T478
MLK3 (rat) HVRRRRGTFKRSKLR T478
MLK3 (cow) HVRRRRGTFKRSKLR T477
S493-p
RDGGERIsMPLDFkH
Upstream
0 3
Treatment
  • BI2536
MLK3 (human) RDGGERIsMPLDFkH S493-p
MLK3 (mouse) RDGGERISMPLDFKH S494
MLK3 (rat) RDGGERISMPLDFKH S494
MLK3 (cow) RDGGERISMPLDFKH S493
K499-ub
IsMPLDFkHRITVQA
0 1
MLK3 (human) IsMPLDFkHRITVQA K499-ub
MLK3 (mouse) ISMPLDFKHRITVQA K500
MLK3 (rat) ISMPLDFKHRITVQA K500
MLK3 (cow) ISMPLDFKHRITVQA K499
S507-p
HRITVQAsPGLDrRR
Upstream
0 28
Treatment
  • HB-EGF
  • ischemia
  • LPA
  • MG132_withdrawal
MLK3 (human) HRITVQAsPGLDrRR S507-p
MLK3 (mouse) HRITVQAsPGLDRRR S508-p
MLK3 (rat) HRITVQAsPGLDRRR S508-p
MLK3 (cow) HRITVQASPGLDRRR S507
R512-m1
QAsPGLDrRRNVFEV
0 1
MLK3 (human) QAsPGLDrRRNVFEV R512-m1
MLK3 (mouse) QAsPGLDRRRNVFEV R513
MLK3 (rat) QAsPGLDRRRNVFEV R513
MLK3 (cow) QASPGLDRRRNVFEV R512
S524-p
FEVGPGDsPtFPRFR
Upstream
1 27
Treatment
  • HB-EGF
  • ischemia
  • LPA
  • MG132_withdrawal
MLK3 (human) FEVGPGDsPtFPRFR S524-p
MLK3 (mouse) FEVGAGDsPtFPRFR S525-p
MLK3 (rat) FEVGAGDsPTFPRFR S525-p
MLK3 (cow) FEVGAGDSPTFPRFR S524
T526-p
VGPGDsPtFPRFRAI
Upstream
0 4
Treatment
  • MG132_withdrawal
MLK3 (human) VGPGDsPtFPRFRAI T526-p
MLK3 (mouse) VGAGDsPtFPRFRAI T527-p
MLK3 (rat) VGAGDsPTFPRFRAI T527
MLK3 (cow) VGAGDSPTFPRFRAI T526
S548-p
GQAWGRQsPRRLEDs
Upstream
0 8
Treatment
  • nocodazole
  • thymidine
MLK3 (human) GQAWGRQsPRRLEDs S548-p
MLK3 (mouse) GQTWGRQSPRRLEDS S549
MLK3 (rat) GQTWGRQSPRRLDDS S549
MLK3 (cow) GQAWGRQSPRRLEDS S548
S555-p
sPRRLEDssNGERRA
1 1
MLK3 (human) sPRRLEDssNGERRA S555-p
MLK3 (mouse) SPRRLEDSSNGERRA S556
MLK3 (rat) SPRRLDDSSNGERRA S556
MLK3 (cow) SPRRLEDSSNGERRA S555
S556-p
PRRLEDssNGERRAC
1 1
MLK3 (human) PRRLEDssNGERRAC S556-p
MLK3 (mouse) PRRLEDSSNGERRAC S557
MLK3 (rat) PRRLDDSSNGERRAC S557
MLK3 (cow) PRRLEDSSNGERRAC S556
S570-p
CWAWGPSsPKPGEAQ
0 1
MLK3 (human) CWAWGPSsPKPGEAQ S570-p
MLK3 (mouse) CWAWGPSSPKPGEAQ S571
MLK3 (rat) CWAWGPSSPKPGEAQ S571
MLK3 (cow) CWAWGPSSPKPGEAQ S570
K624-ub
SLEPEEPkRPVPAER
0 1
MLK3 (human) SLEPEEPkRPVPAER K624-ub
MLK3 (mouse) SPEPEEPRRAGPTER R625
MLK3 (rat) SPEPEEPRRSGPTER R625
MLK3 (cow) SPEPEEPRRPGPTEL R624
S654-p
RGTALLAsLGLGRDL
1 1
MLK3 (human) RGTALLAsLGLGRDL S654-p
MLK3 (mouse) RGTALLASLGLGRDL S655
MLK3 (rat) RGTALLASLGLGRDL S655
MLK3 (cow) RGTALLASLGLGRDL S654
S674-p
PGRERGEsPTtPPTP
Upstream
Downstream
3 0
Effects on Modified Protein
  • activity, inhibited
Effects on Biological Processes:
  • apoptosis, inhibited
  • carcinogenesis, induced
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Regulatory protein:
  • HER2 (human)
Treatment
  • anti-HER2
  • lapatinib
  • LY294002
  • pictilisib
  • siRNA
MLK3 (human) PGRERGEsPTtPPTP S674-p
MLK3 (mouse) LSRERGESPTAPPPA S675
MLK3 (rat) LSRERGESPTAPPPA S675
MLK3 (cow) SGRERVEQPSPTPPR Q674
T677-p
ERGEsPTtPPTPTPA
0 1
MLK3 (human) ERGEsPTtPPTPTPA T677-p
MLK3 (mouse) ERGESPTAPPPAQMP A678
MLK3 (rat) ERGESPTAPPPAQMA A678
MLK3 (cow) ERVEQPSPTPPRSSL P677
S693-p
CPTEPPPsPLICFSL
0 3
MLK3 (human) CPTEPPPsPLICFSL S693-p
MLK3 (mouse) CPPELPSTPLIRLSQ T695
MLK3 (rat) CPPDLPSTPLIHLSQ T695
MLK3 (cow) SPTEPPPSPLIRFSS S697
T702-p
LICFSLKtPDsPPtP
Upstream
0 2
Treatment
  • MG132_withdrawal
MLK3 (human) LICFSLKtPDsPPtP T702-p
MLK3 (mouse) LIRLSQTTPDAHSSP T704
MLK3 (rat) LIHLSQATPDARGPL T704
MLK3 (cow) LIRFSSETPETPASP T706
S705-p
FSLKtPDsPPtPAPL
Upstream
Downstream
2 6
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • ERK1 (human)
MLK3 (human) FSLKtPDsPPtPAPL S705-p
MLK3 (mouse) QTTPDAHSSPTPGPL S709
MLK3 (rat) QATPDARGPLTPAPL G709
MLK3 (cow) PLSPDASGPAAPAPP G720
T708-p
KtPDsPPtPAPLLLD
0 3
MLK3 (human) KtPDsPPtPAPLLLD T708-p
MLK3 (mouse) PDAHSSPTPGPLLLD T712
MLK3 (rat) PDARGPLTPAPLLLD T712
MLK3 (cow) PDASGPAAPAPPLLL A723
S724-p
GIPVGQRsAKsPRRE
1 1
MLK3 (human) GIPVGQRsAKsPRRE S724-p
MLK3 (mouse) GVPSGQPSAKSPRRE S728
MLK3 (rat) GVSSGQPSAKSPRRE S728
MLK3 (cow) VPAAGQPSAKSRRRE S741
S727-p
VGQRsAKsPRREEEP
1 1
MLK3 (human) VGQRsAKsPRREEEP S727-p
MLK3 (mouse) SGQPSAKSPRREETR S731
MLK3 (rat) SGQPSAKSPRREETR S731
MLK3 (cow) AGQPSAKSRRREEER S744
T738-p
EEEPRGGtVsPPPGT
0 3
MLK3 (human) EEEPRGGtVsPPPGT T738-p
MLK3 (mouse) REETRGRTVsPPPGI T741
MLK3 (rat) REETRGRTVSPPPGI T741
MLK3 (cow) EEERRASAVSPPPGI A755
S740-p
EPRGGtVsPPPGTsR
0 21
MLK3 (human) EPRGGtVsPPPGTsR S740-p
MLK3 (mouse) ETRGRTVsPPPGISR S743-p
MLK3 (rat) ETRGRTVSPPPGISR S743
MLK3 (cow) ERRASAVSPPPGISR S757
S746-p
VsPPPGTsRsAPGtP
0 1
MLK3 (human) VsPPPGTsRsAPGtP S746-p
MLK3 (mouse) VsPPPGISRSAPGTP S749
MLK3 (rat) VSPPPGISRSAPGTP S749
MLK3 (cow) VSPPPGISRSAPGTP S763
S748-p
PPPGTsRsAPGtPGt
Upstream
0 10
Treatment
  • LPA
  • nocodazole
  • thymidine
MLK3 (human) PPPGTsRsAPGtPGt S748-p
MLK3 (mouse) PPPGISRSAPGTPGt S751
MLK3 (rat) PPPGISRSAPGTPGT S751
MLK3 (cow) PPPGISRSAPGTPGT S765
T752-p
TsRsAPGtPGtPRsP
Upstream
0 3
Treatment
  • nocodazole
  • thymidine
MLK3 (human) TsRsAPGtPGtPRsP T752-p
MLK3 (mouse) ISRSAPGTPGtPRsP T755
MLK3 (rat) ISRSAPGTPGTPRsP T755
MLK3 (cow) ISRSAPGTPGTPRSP T769
T755-p
sAPGtPGtPRsPPLG
Upstream
0 6
Treatment
  • nocodazole
  • thymidine
MLK3 (human) sAPGtPGtPRsPPLG T755-p
MLK3 (mouse) SAPGTPGtPRsPPLG T758-p
MLK3 (rat) SAPGTPGTPRsPPLG T758
MLK3 (cow) SAPGTPGTPRSPPLG T772
S758-p
GtPGtPRsPPLGLIS
Upstream
Downstream
3 14
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • ERK1 (human)
Treatment
  • nocodazole
  • thymidine
MLK3 (human) GtPGtPRsPPLGLIS S758-p
MLK3 (mouse) GTPGtPRsPPLGLIs S761-p
MLK3 (rat) GTPGTPRsPPLGLIS S761-p
MLK3 (cow) GTPGTPRSPPLGLIS S775
S765
sPPLGLISRPRPsPL
0 1
MLK3 (human) sPPLGLISRPRPsPL S765
MLK3 (mouse) sPPLGLIsRPRPsPL S768-p
MLK3 (rat) sPPLGLISRPRPSPL S768
MLK3 (cow) SPPLGLISRPRPSPL S782
S770-p
LISRPRPsPLRsRID
1 4
MLK3 (human) LISRPRPsPLRsRID S770-p
MLK3 (mouse) LIsRPRPsPLRsRID S773-p
MLK3 (rat) LISRPRPSPLRNRID S773
MLK3 (cow) LISRPRPSPLRSRID S787
S774-p
PRPsPLRsRIDPWSF
0 1
MLK3 (human) PRPsPLRsRIDPWSF S774-p
MLK3 (mouse) PRPsPLRsRIDPWSF S777-p
MLK3 (rat) PRPSPLRNRIDPWSF N777
MLK3 (cow) PRPSPLRSRIDPWSF S791
S783-p
IDPWSFVsAGPRPsP
0 1
MLK3 (human) IDPWSFVsAGPRPsP S783-p
MLK3 (mouse) IDPWSFVsAGPRPsP S786-p
MLK3 (rat) IDPWSFVSAGPRPSP S786
MLK3 (cow) IDPWSFVSAGPRPSP S800
S789-p
VsAGPRPsPLPsPQP
Upstream
Downstream
1 21
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, induced
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • kenpaullone
MLK3 (human) VsAGPRPsPLPsPQP S789-p
MLK3 (mouse) VsAGPRPsPLPsPQP S792-p
MLK3 (rat) VSAGPRPSPLPSPQP S792
MLK3 (cow) VSAGPRPSPLPsPQP S806
S793-p
PRPsPLPsPQPAPRR
Upstream
Downstream
2 27
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, induced
Kinase, in vitro:
  • GSK3B (human)
Putative in vivo kinases:
  • GSK3B (human)
Treatment
  • ischemia
  • kenpaullone
MLK3 (human) PRPsPLPsPQPAPRR S793-p
MLK3 (mouse) PRPsPLPsPQPAPRR S796-p
MLK3 (rat) PRPSPLPSPQPAPRR S796
MLK3 (cow) PRPSPLPsPQPAPRR S810-p
S815-p
DSDPFWDsPPANPFQ
0 1
MLK3 (human) DSDPFWDsPPANPFQ S815-p
MLK3 (mouse) DSDPFWDSPPANPFR S818
MLK3 (rat) DSDPFWDSPPANPFR S818
MLK3 (cow) DSDPFWDSPPANPFR S832