Other Species / Isoforms
  IRS2 (mouse)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S3-p
_____MAsAPLPGPP
Upstream
0 6
Treatment
  • insulin
  • LY294002
IRS2 (human) _____MAsPPRHGPP S3-p
IRS2 (mouse) _____MAsAPLPGPP S3-p
IRS2 (rat) _____MASAPLPGPP S3
S30
NNNNNNHSVRKCGYL
0 1
IRS2 (human) NNNNNNHsVRKCGYL S30-p
IRS2 (mouse) NNNNNNHSVRKCGYL S30
IRS2 (rat) NNNNNNHSVRKCGYL S31
S66-p
EASAAGGsPPQPPRL
Upstream
1 4
Treatment
  • IGF-1
  • insulin
IRS2 (human) EATAGGGSAPQPPRL S66
IRS2 (mouse) EASAAGGsPPQPPRL S66-p
IRS2 (rat) EAAAAGGSPPQPPRL S67
Y75
PQPPRLEYyESEKKW
0 18
IRS2 (human) PQPPRLEyyEsEKKW Y75-p
IRS2 (mouse) PQPPRLEYyESEKKW Y75
IRS2 (rat) PQPPRLEYYESEKKW Y76
Y76-p
QPPRLEYyESEKKWR
0 5
IRS2 (human) QPPRLEyyEsEKKWR Y76-p
IRS2 (mouse) QPPRLEYyESEKKWR Y76-p
IRS2 (rat) QPPRLEYYESEKKWK Y77
S78
PRLEYyESEKKWRSK
0 1
IRS2 (human) PRLEyyEsEKKWRSK S78-p
IRS2 (mouse) PRLEYyESEKKWRSK S78
IRS2 (rat) PRLEYYESEKKWKSK S79
Y111
RADAKHKYLIALYtK
0 4
IRS2 (human) RADAKHKyLIALYTK Y111-p
IRS2 (mouse) RADAKHKYLIALYtK Y111
IRS2 (rat) RADAKHKYLIALYTK Y112
T117-p
KYLIALYtKDEYFAV
0 1
IRS2 (human) KyLIALYTKDEYFAV T117
IRS2 (mouse) KYLIALYtKDEYFAV T117-p
IRS2 (rat) KYLIALYTKDEYFAV T118
Y181
AAGCDDNYGLVTPAT
0 1
IRS2 (human) AAGAEDSyGLVAPAT Y184-p
IRS2 (mouse) AAGCDDNYGLVTPAT Y181
IRS2 (rat) AAGCDDNYGLVTPAT Y182
K292
LEAMKALKELFEFRP
0 1
IRS2 (human) LEAMKALkELFEFRP K295-ub
IRS2 (mouse) LEAMKALKELFEFRP K292
IRS2 (rat) LEAMKALKELFEFRP K293
S301-p
LFEFRPRsKsQssGS
0 9
IRS2 (human) LFEFRPRsksQssGs S304-p
IRS2 (mouse) LFEFRPRsKsQssGS S301-p
IRS2 (rat) LFEFRPRSKsQSSGS S302
K302
FEFRPRsKsQssGSS
0 1
IRS2 (human) FEFRPRsksQssGss K305-ub
IRS2 (mouse) FEFRPRsKsQssGSS K302
IRS2 (rat) FEFRPRSKsQSSGSS K303
S303-p
EFRPRsKsQssGSSA
Upstream
Downstream
2 63
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • PKCB iso2 (mouse)
Putative in vivo kinases:
  • PKCB iso2 (mouse)
Treatment
  • angiotensin_2
  • IGF-1
  • insulin
  • losartan
  • LPS
  • phorbol_ester
  • ruboxistaurin
  • siRNA
IRS2 (human) EFRPRsksQssGssA S306-p
IRS2 (mouse) EFRPRsKsQssGSSA S303-p
IRS2 (rat) EFRPRSKsQSSGSSA S304-p
S305-p
RPRsKsQssGSSAtH
Upstream
1 5
Treatment
  • IGF-1
  • LPA
IRS2 (human) RPRsksQssGssAtH S308-p
IRS2 (mouse) RPRsKsQssGSSAtH S305-p
IRS2 (rat) RPRSKsQSSGSSATH S306
S306-p
PRsKsQssGSSAtHP
Upstream
0 2
Treatment
  • insulin
IRS2 (human) PRsksQssGssAtHP S309-p
IRS2 (mouse) PRsKsQssGSSAtHP S306-p
IRS2 (rat) PRSKsQSSGSSATHP S307
S308
sKsQssGSSAtHPIS
0 3
IRS2 (human) sksQssGssAtHPIS S311-p
IRS2 (mouse) sKsQssGSSAtHPIS S308
IRS2 (rat) SKsQSSGSSATHPIS S309
S309
KsQssGSSAtHPISV
0 2
IRS2 (human) ksQssGssAtHPISV S312-p
IRS2 (mouse) KsQssGSSAtHPISV S309
IRS2 (rat) KsQSSGSSATHPISV S310
T311-p
QssGSSAtHPISVPG
Upstream
0 7
Treatment
  • insulin
  • LPA
IRS2 (human) QssGssAtHPISVPG T314-p
IRS2 (mouse) QssGSSAtHPISVPG T311-p
IRS2 (rat) QSSGSSATHPISVPG T312
S331
HLVNLPPSQTGLVRR
0 1
IRS2 (human) HLVNLPPsQTGLVRR S334-p
IRS2 (mouse) HLVNLPPSQTGLVRR S331
IRS2 (rat) HLVNLPPSQTGLVRR S332
S339-p
QTGLVRRsRTDsLAA
0 2
IRS2 (human) QTGLVRRsRtDsLAA S342-p
IRS2 (mouse) QTGLVRRsRTDsLAA S339-p
IRS2 (rat) QTGLVRRSRTDsLAA S340
T341
GLVRRsRTDsLAAtP
0 1
IRS2 (human) GLVRRsRtDsLAAtP T344-p
IRS2 (mouse) GLVRRsRTDsLAAtP T341
IRS2 (rat) GLVRRSRTDsLAAtP T342
S343-p
VRRsRTDsLAAtPPA
Upstream
1 32
Treatment
  • insulin
  • LY294002
  • MK-2206
  • phorbol_ester
IRS2 (human) VRRsRtDsLAAtPPA S346-p
IRS2 (mouse) VRRsRTDsLAAtPPA S343-p
IRS2 (rat) VRRSRTDsLAAtPPA S344-p
T347-p
RTDsLAAtPPAAKCT
Upstream
2 45
Treatment
  • IGF-1
  • insulin
  • LY294002
  • MK-2206
IRS2 (human) RtDsLAAtPPAAKCS T350-p
IRS2 (mouse) RTDsLAAtPPAAKCT T347-p
IRS2 (rat) RTDsLAAtPPAAKCT T348-p
S355
PPAAKCTSCRVRtAs
0 1
IRS2 (human) PPAAKCSsCRVRtAs S358-p
IRS2 (mouse) PPAAKCTSCRVRtAs S355
IRS2 (rat) PPAAKCTSCRVRTAS S356
T360-p
CTSCRVRtAsEGDGG
0 25
IRS2 (human) CSsCRVRtAsEGDGG T363-p
IRS2 (mouse) CTSCRVRtAsEGDGG T360-p
IRS2 (rat) CTSCRVRTASEGDGG T361
S362-p
SCRVRtAsEGDGGAA
Upstream
0 65
Treatment
  • insulin
  • refeeding
IRS2 (human) sCRVRtAsEGDGGAA S365-p
IRS2 (mouse) SCRVRtAsEGDGGAA S362-p
IRS2 (rat) SCRVRTASEGDGGAA S363
S381-p
TAGGRPMsVAGsPLs
0 22
IRS2 (human) AAGARPVsVAGsPLs S384-p
IRS2 (mouse) TAGGRPMsVAGsPLs S381-p
IRS2 (rat) TAGGRPMSVAGSPLS S382
S385-p
RPMsVAGsPLsPGPV
Upstream
1 61
Treatment
  • IGF-1
  • insulin
  • LY294002
  • MK-2206
  • refeeding
IRS2 (human) RPVsVAGsPLsPGPV S388-p
IRS2 (mouse) RPMsVAGsPLsPGPV S385-p
IRS2 (rat) RPMSVAGSPLSPGPV S386
S388-p
sVAGsPLsPGPVRAP
Upstream
2 118
Kinase, in vitro:
  • CDK4 (human)
Putative in vivo kinases:
  • CDK4 (mouse)
Treatment
  • IGF-1
  • insulin
IRS2 (human) sVAGsPLsPGPVRAP S391-p
IRS2 (mouse) sVAGsPLsPGPVRAP S388-p
IRS2 (rat) SVAGSPLSPGPVRAP S389
S397
GPVRAPLSRSHtLsA
0 6
IRS2 (human) GPVRAPLsRSHtLsG S400-p
IRS2 (mouse) GPVRAPLSRSHtLsA S397
IRS2 (rat) GPVRAPLSRSHTLSA S398
T401-p
APLSRSHtLsAGCGG
Upstream
1 16
Treatment
  • IGF-1
  • insulin
  • MK-2206
IRS2 (human) APLsRSHtLsGGCGG T404-p
IRS2 (mouse) APLSRSHtLsAGCGG T401-p
IRS2 (rat) APLSRSHTLSAGCGG T402
S403-p
LSRSHtLsAGCGGRP
Upstream
0 3
Treatment
  • insulin
IRS2 (human) LsRSHtLsGGCGGrG S406-p
IRS2 (mouse) LSRSHtLsAGCGGRP S403-p
IRS2 (rat) LSRSHTLSAGCGGRP S404
R409
LsAGCGGRPSKVTLA
0 17
IRS2 (human) LsGGCGGrGSKVALL R412-m1
IRS2 (mouse) LsAGCGGRPSKVTLA R409
IRS2 (rat) LSAGCGGRPSKVALA R410
S425-gl
AGGALQHsRSMSMPV
0 1
IRS2 (human) AGGALQHSrsMsMPV S428
IRS2 (mouse) AGGALQHsRSMSMPV S425-gl
IRS2 (rat) AGGALQHSRSMSMPV S426
R426
GGALQHsRSMSMPVA
0 16
IRS2 (human) GGALQHSrsMsMPVA R429-m1
IRS2 (mouse) GGALQHsRSMSMPVA R426
IRS2 (rat) GGALQHSRSMSMPVA R427
S427
GALQHsRSMSMPVAH
0 1
IRS2 (human) GALQHSrsMsMPVAH S430-p
IRS2 (mouse) GALQHsRSMSMPVAH S427
IRS2 (rat) GALQHSRSMSMPVAH S428
S429
LQHsRSMSMPVAHSP
0 1
IRS2 (human) LQHSrsMsMPVAHSP S432-p
IRS2 (mouse) LQHsRSMSMPVAHSP S429
IRS2 (rat) LQHSRSMSMPVAHSP S430
S484-p
RPSSGSAsASGsPSD
Upstream
1 0
Kinase, in vitro:
  • GSK3A (human)
IRS2 (human) RPSSGSASASGSPSD S487
IRS2 (mouse) RPSSGSAsASGsPSD S484-p
IRS2 (rat) RPSSGSASASGSPSD S485
S488-p
GSAsASGsPSDPGFM
Upstream
1 0
Kinase, in vitro:
  • JNK1 (human)
IRS2 (human) GSASASGSPSDPGFM S491
IRS2 (mouse) GSAsASGsPSDPGFM S488-p
IRS2 (rat) GSASASGSPSDPGFM S489
S502
MSLDEYGSSPGDLRA
0 2
IRS2 (human) MSLDEYGssPGDLRA S505-p
IRS2 (mouse) MSLDEYGSSPGDLRA S502
IRS2 (rat) MSLDEYGSSPGDLRA S503
S503
SLDEYGSSPGDLRAF
0 2
IRS2 (human) SLDEYGssPGDLRAF S506-p
IRS2 (mouse) SLDEYGSSPGDLRAF S503
IRS2 (rat) SLDEYGSSPGDLRAF S504
S512-p
GDLRAFSsHRsNtPE
0 4
IRS2 (human) GDLRAFCsHRsNtPE S515-p
IRS2 (mouse) GDLRAFSsHRsNtPE S512-p
IRS2 (rat) GDLRAFSSHRsNtPE S513
S515-p
RAFSsHRsNtPEsIA
0 27
IRS2 (human) RAFCsHRsNtPEsIA S518-p
IRS2 (mouse) RAFSsHRsNtPEsIA S515-p
IRS2 (rat) RAFSSHRsNtPESIA S516-p
T517-p
FSsHRsNtPEsIAEt
Upstream
1 40
Treatment
  • IGF-1
  • insulin
  • MK-2206
IRS2 (human) FCsHRsNtPEsIAEt T520-p
IRS2 (mouse) FSsHRsNtPEsIAEt T517-p
IRS2 (rat) FSSHRsNtPESIAEt T518-p
S520-p
HRsNtPEsIAEtPPA
Upstream
0 32
Treatment
  • insulin
  • LY294002
  • MK-2206
  • refeeding
IRS2 (human) HRsNtPEsIAEtPPA S523-p
IRS2 (mouse) HRsNtPEsIAEtPPA S520-p
IRS2 (rat) HRsNtPESIAEtPPA S521
T524-p
tPEsIAEtPPARDGS
Upstream
0 63
Treatment
  • insulin
  • LY294002
  • MK-2206
IRS2 (human) tPEsIAEtPPARDGG T527-p
IRS2 (mouse) tPEsIAEtPPARDGS T524-p
IRS2 (rat) tPESIAEtPPARDGS T525-p
Y536
DGSGGELYGyMSMDR
0 7
IRS2 (human) GGGGGEFyGyMtMDR Y540-p
IRS2 (mouse) DGSGGELYGyMSMDR Y536
IRS2 (rat) DGSGGELYGYMSMDR Y537
Y538-p
SGGELYGyMSMDRPL
Upstream
1 43
Treatment
  • IGF-1
  • insulin
  • SB216763
IRS2 (human) GGGEFyGyMtMDRPL Y542-p
IRS2 (mouse) SGGELYGyMSMDRPL Y538-p
IRS2 (rat) SGGELYGYMSMDRPL Y539
S540
GELYGyMSMDRPLSH
0 4
IRS2 (human) GEFyGyMtMDRPLsH T544-p
IRS2 (mouse) GELYGyMSMDRPLSH S540
IRS2 (rat) GELYGYMSMDRPLSH S541
S546
MSMDRPLSHCGRPYR
0 5
IRS2 (human) MtMDRPLsHCGRSYR S550-p
IRS2 (mouse) MSMDRPLSHCGRPYR S546
IRS2 (rat) MSMDRPLSHCGRPYR S547
S556-p
GRPYRRVsGDGAQDL
Upstream
Downstream
2 60
Effects on Modified Protein
  • protein degradation
Effects on Biological Processes:
  • cell cycle regulation
Kinase, in vitro:
  • PLK1 (mouse)
Putative in vivo kinases:
  • PLK1 (mouse)
Treatment
  • IGF-1
  • LPS
IRS2 (human) GRSYRRVsGDAAQDL S560-p
IRS2 (mouse) GRPYRRVsGDGAQDL S556-p
IRS2 (rat) GRPYRRVsGDGAQDL S557-p
R565
DGAQDLDRGLRKRtY
0 9
IRS2 (human) DAAQDLDrGLRKRty R569-m1
IRS2 (mouse) DGAQDLDRGLRKRtY R565
IRS2 (rat) DGAQDLDRGLRKRTY R566
T571-p
DRGLRKRtYsLttPA
0 6
IRS2 (human) DrGLRKRtysLttPA T575-p
IRS2 (mouse) DRGLRKRtYsLttPA T571-p
IRS2 (rat) DRGLRKRTYsLTTPA T572
Y572
RGLRKRtYsLttPAR
0 7
IRS2 (human) rGLRKRtysLttPAR Y576-p
IRS2 (mouse) RGLRKRtYsLttPAR Y572
IRS2 (rat) RGLRKRTYsLTTPAR Y573
S573-p
GLRKRtYsLttPARQ
Upstream
Downstream
1 49
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • Akt-I-1,2
  • IGF-1
  • insulin
  • LPA
  • MK-2206
  • wortmannin
IRS2 (human) GLRKRtysLttPARQ S577-p
IRS2 (mouse) GLRKRtYsLttPARQ S573-p
IRS2 (rat) GLRKRTYsLTTPARQ S574-p
T575-p
RKRtYsLttPARQRQ
0 6
IRS2 (human) RKRtysLttPARQRP T579-p
IRS2 (mouse) RKRtYsLttPARQRQ T575-p
IRS2 (rat) RKRTYsLTTPARQRQ T576
T576-p
KRtYsLttPARQRQV
0 6
IRS2 (human) KRtysLttPARQRPV T580-p
IRS2 (mouse) KRtYsLttPARQRQV T576-p
IRS2 (rat) KRTYsLTTPARQRQV T577
S587
QRQVPQPSSAsLDEy
0 1
IRS2 (human) QRPVPQPssAsLDEy S591-p
IRS2 (mouse) QRQVPQPSSAsLDEy S587
IRS2 (rat) QRQVPQPSSAsLDEY S588
S588
RQVPQPSSAsLDEyT
0 1
IRS2 (human) RPVPQPssAsLDEyt S592-p
IRS2 (mouse) RQVPQPSSAsLDEyT S588
IRS2 (rat) RQVPQPSSAsLDEYT S589
S590-p
VPQPSSAsLDEyTLM
Upstream
0 33
Treatment
  • insulin
  • LY294002
  • refeeding
IRS2 (human) VPQPssAsLDEytLM S594-p
IRS2 (mouse) VPQPSSAsLDEyTLM S590-p
IRS2 (rat) VPQPSSAsLDEYTLM S591-p
Y594-p
SSAsLDEyTLMRATF
Upstream
0 162
Treatment
  • insulin
IRS2 (human) ssAsLDEytLMRAtF Y598-p
IRS2 (mouse) SSAsLDEyTLMRATF Y594-p
IRS2 (rat) SSAsLDEYTLMRATF Y595
T595
SAsLDEyTLMRATFs
0 4
IRS2 (human) sAsLDEytLMRAtFs T599-p
IRS2 (mouse) SAsLDEyTLMRATFs T595
IRS2 (rat) SAsLDEYTLMRATFS T596
T600
EyTLMRATFsGsSGR
0 1
IRS2 (human) EytLMRAtFsGsAGR T604-p
IRS2 (mouse) EyTLMRATFsGsSGR T600
IRS2 (rat) EYTLMRATFSGSSGR T601
S602-p
TLMRATFsGsSGRLC
0 4
IRS2 (human) tLMRAtFsGsAGRLC S606-p
IRS2 (mouse) TLMRATFsGsSGRLC S602-p
IRS2 (rat) TLMRATFSGSSGRLC S603
S604-p
MRATFsGsSGRLCPS
Upstream
0 17
Treatment
  • insulin
  • LY294002
  • MK-2206
IRS2 (human) MRAtFsGsAGRLCPs S608-p
IRS2 (mouse) MRATFsGsSGRLCPS S604-p
IRS2 (rat) MRATFSGSSGRLCPS S605
S611
sSGRLCPSFPASsPK
0 3
IRS2 (human) sAGRLCPsCPAssPK S615-p
IRS2 (mouse) sSGRLCPSFPASsPK S611
IRS2 (rat) SSGRLCPSLPASSPK S612
S615
LCPSFPASsPKVAYN
0 3
IRS2 (human) LCPsCPAssPKVAyH S619-p
IRS2 (mouse) LCPSFPASsPKVAYN S615
IRS2 (rat) LCPSLPASSPKVAYN S616
S616-p
CPSFPASsPKVAYNP
Upstream
0 12
Putative in vivo kinases:
  • mTOR (mouse)
Treatment
  • insulin
  • LY294002
  • Torin1
IRS2 (human) CPsCPAssPKVAyHP S620-p
IRS2 (mouse) CPSFPASsPKVAYNP S616-p
IRS2 (rat) CPSLPASSPKVAYNP S617
Y621
ASsPKVAYNPyPEDy
0 2
IRS2 (human) AssPKVAyHPyPEDy Y625-p
IRS2 (mouse) ASsPKVAYNPyPEDy Y621
IRS2 (rat) ASSPKVAYNPYPEDY Y622
Y624-p
PKVAYNPyPEDyGDI
Upstream
Downstream
1 4
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • INSR (human)
Treatment
  • insulin
IRS2 (human) PKVAyHPyPEDyGDI Y628-p
IRS2 (mouse) PKVAYNPyPEDyGDI Y624-p
IRS2 (rat) PKVAYNPYPEDYGDI Y625
Y628-p
YNPyPEDyGDIEIGs
Upstream
Downstream
2 52
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • INSR (human)
IRS2 (human) yHPyPEDyGDIEIGs Y632-p
IRS2 (mouse) YNPyPEDyGDIEIGs Y628-p
IRS2 (rat) YNPYPEDYGDIEIGS Y629
S635-p
yGDIEIGsHKSSSSN
Upstream
0 6
Treatment
  • insulin
  • LY294002
  • MK-2206
IRS2 (human) yGDIEIGsHRsSSsN S639-p
IRS2 (mouse) yGDIEIGsHKSSSSN S635-p
IRS2 (rat) YGDIEIGSHKSSSSN S636
S638
IEIGsHKSSSSNLGA
0 1
IRS2 (human) IEIGsHRsSSsNLGA S642-p
IRS2 (mouse) IEIGsHKSSSSNLGA S638
IRS2 (rat) IEIGSHKSSSSNLGA S639
S641
GsHKSSSSNLGADDG
0 2
IRS2 (human) GsHRsSSsNLGADDG S645-p
IRS2 (mouse) GsHKSSSSNLGADDG S641
IRS2 (rat) GSHKSSSSNLGADDG S642
Y649-p
NLGADDGyMPMtPGA
Upstream
Downstream
1 545
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Treatment
  • IGF-1
  • insulin
  • SB216763
IRS2 (human) NLGADDGyMPMtPGA Y653-p
IRS2 (mouse) NLGADDGyMPMtPGA Y649-p
IRS2 (rat) NLGADDGyMPMTPGA Y650-p
T653-p
DDGyMPMtPGAALRs
Upstream
1 4
Kinase, in vitro:
  • ERK2 (mouse)
IRS2 (human) DDGyMPMtPGAALAG T657-p
IRS2 (mouse) DDGyMPMtPGAALRs T653-p
IRS2 (rat) DDGyMPMTPGAALRS T654
S660-p
tPGAALRsGGPNsCK
0 1
IRS2 (human) tPGAALAGSGSGSCR G664
IRS2 (mouse) tPGAALRsGGPNsCK S660-p
IRS2 (rat) TPGAALRSGGPNsCK S661
S665-p
LRsGGPNsCKsDDyM
0 3
IRS2 (human) LAGSGSGSCRsDDyM S669
IRS2 (mouse) LRsGGPNsCKsDDyM S665-p
IRS2 (rat) LRSGGPNsCKsDDyM S666-p
S668-p
GGPNsCKsDDyMPMs
0 22
IRS2 (human) SGSGSCRsDDyMPMs S672-p
IRS2 (mouse) GGPNsCKsDDyMPMs S668-p
IRS2 (rat) GGPNsCKsDDyMPMs S669-p
Y671-p
NsCKsDDyMPMsPtS
Upstream
Downstream
3 372
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Regulatory protein:
  • IRS2 (mouse)
  • PKCB iso2 (mouse)
Treatment
  • angiotensin_2
  • IGF-1
  • insulin
  • phorbol_ester
  • SB216763
IRS2 (human) GSCRsDDyMPMsPAs Y675-p
IRS2 (mouse) NsCKsDDyMPMsPtS Y671-p
IRS2 (rat) NsCKsDDyMPMsPTS Y672-p
S675-p
sDDyMPMsPtSVSAP
Upstream
Downstream
2 26
Effects on Modified Protein
  • molecular association, regulation
Effects on Biological Processes:
  • signaling pathway regulation
Kinase, in vitro:
  • PKCB iso2 (mouse)
Putative in vivo kinases:
  • PKCB iso2 (mouse)
Treatment
  • IGF-1
  • phorbol_ester
  • ruboxistaurin
  • siRNA
IRS2 (human) sDDyMPMsPAsVSAP S679-p
IRS2 (mouse) sDDyMPMsPtSVSAP S675-p
IRS2 (rat) sDDyMPMsPTSVSAP S676-p
T677-p
DyMPMsPtSVSAPKQ
0 1
IRS2 (human) DyMPMsPAsVSAPKQ A681
IRS2 (mouse) DyMPMsPtSVSAPKQ T677-p
IRS2 (rat) DyMPMsPTSVSAPKQ T678
S678
yMPMsPtSVSAPKQI
0 3
IRS2 (human) yMPMsPAsVSAPKQI S682-p
IRS2 (mouse) yMPMsPtSVSAPKQI S678
IRS2 (rat) yMPMsPTSVSAPKQI S679
-
gap
0 1
IRS2 (human) gap -
IRS2 (mouse) gap -
IRS2 (rat) KQILQPRsAAALPPS S691-p
P705
GAAVPAPPSGVGRTF
0 2
IRS2 (human) GPAGPAPtsAAGRTF T713-p
IRS2 (mouse) GAAVPAPPSGVGRTF P705
IRS2 (rat) GAAVPAPPsGAGRTF P706
S706
AAVPAPPSGVGRTFP
0 2
IRS2 (human) PAGPAPtsAAGRTFP S714-p
IRS2 (mouse) AAVPAPPSGVGRTFP S706
IRS2 (rat) AAVPAPPsGAGRTFP S707-p
N715
VGRTFPVNGGGYKAs
0 1
IRS2 (human) AGRTFPAsGGGYKAs S723-p
IRS2 (mouse) VGRTFPVNGGGYKAs N715
IRS2 (rat) AGRTFPVNGGGYKAS N716
S722-p
NGGGYKAssPAEssP
Upstream
1 4
Treatment
  • IGF-1
IRS2 (human) sGGGYKAssPAEssP S730-p
IRS2 (mouse) NGGGYKAssPAEssP S722-p
IRS2 (rat) NGGGYKASsPAESsP S723
S723-p
GGGYKAssPAEssPE
Downstream
4 18
Effects on Biological Processes:
  • signaling pathway regulation
IRS2 (human) GGGYKAssPAEssPE S731-p
IRS2 (mouse) GGGYKAssPAEssPE S723-p
IRS2 (rat) GGGYKASsPAESsPE S724-p
S727-p
KAssPAEssPEDsGy
Upstream
1 19
Treatment
  • IGF-1
  • insulin
  • LY294002
IRS2 (human) KAssPAEssPEDsGy S735-p
IRS2 (mouse) KAssPAEssPEDsGy S727-p
IRS2 (rat) KASsPAESsPEDSGy S728
S728-p
AssPAEssPEDsGyM
Upstream
1 54
Treatment
  • IGF-1
IRS2 (human) AssPAEssPEDsGyM S736-p
IRS2 (mouse) AssPAEssPEDsGyM S728-p
IRS2 (rat) ASsPAESsPEDSGyM S729-p
S732-p
AEssPEDsGyMRMWC
0 10
IRS2 (human) AEssPEDsGyMRMWC S740-p
IRS2 (mouse) AEssPEDsGyMRMWC S732-p
IRS2 (rat) AESsPEDSGyMRMWC S733
Y734-p
ssPEDsGyMRMWCGS
Upstream
2 413
Treatment
  • insulin
  • SB216763
IRS2 (human) ssPEDsGyMRMWCGS Y742-p
IRS2 (mouse) ssPEDsGyMRMWCGS Y734-p
IRS2 (rat) SsPEDSGyMRMWCGS Y735-p
S744
MWCGSKLSMENPDPK
0 3
IRS2 (human) MWCGSKLsMEHADGK S752-p
IRS2 (mouse) MWCGSKLSMENPDPK S744
IRS2 (rat) MWCGSKLSMENPDPK S745
Y758-p
KLLPNGDyLNMsPSE
1 33
IRS2 (human) KLLPNGDyLNVsPsD Y766-p
IRS2 (mouse) KLLPNGDyLNMsPSE Y758-p
IRS2 (rat) KLLPNGDYLNMSPSE Y759
S762-p
NGDyLNMsPSEAGTA
Upstream
1 10
Treatment
  • IGF-1
  • insulin
  • LY294002
  • refeeding
IRS2 (human) NGDyLNVsPsDAVtt S770-p
IRS2 (mouse) NGDyLNMsPSEAGTA S762-p
IRS2 (rat) NGDYLNMSPSEAGTA S763
S764
DyLNMsPSEAGTAGt
0 8
IRS2 (human) DyLNVsPsDAVttGt S772-p
IRS2 (mouse) DyLNMsPSEAGTAGt S764
IRS2 (rat) DYLNMSPSEAGTAGT S765
T768
MsPSEAGTAGtPPDF
0 1
IRS2 (human) VsPsDAVttGtPPDF T776-p
IRS2 (mouse) MsPSEAGTAGtPPDF T768
IRS2 (rat) MSPSEAGTAGTPPDF T769
A769
sPSEAGTAGtPPDFS
0 2
IRS2 (human) sPsDAVttGtPPDFF T777-p
IRS2 (mouse) sPSEAGTAGtPPDFS A769
IRS2 (rat) SPSEAGTAGTPPDFF A770
T771-p
SEAGTAGtPPDFSAA
Upstream
0 17
Treatment
  • insulin
  • LY294002
  • refeeding
IRS2 (human) sDAVttGtPPDFFSA T779-p
IRS2 (mouse) SEAGTAGtPPDFSAA T771-p
IRS2 (rat) SEAGTAGTPPDFFSA T772
Y794
KGIPGHCYSSLPRSY
0 4
IRS2 (human) RGVPGCCyssLPRsY Y803-p
IRS2 (mouse) KGIPGHCYSSLPRSY Y794
IRS2 (rat) KGVPGHCYSSLPRSY Y796
S795
GIPGHCYSSLPRSYK
0 4
IRS2 (human) GVPGCCyssLPRsYK S804-p
IRS2 (mouse) GIPGHCYSSLPRSYK S795
IRS2 (rat) GVPGHCYSSLPRSYK S797
S796
IPGHCYSSLPRSYKA
0 8
IRS2 (human) VPGCCyssLPRsYKA S805-p
IRS2 (mouse) IPGHCYSSLPRSYKA S796
IRS2 (rat) VPGHCYSSLPRSYKA S798
S800
CYSSLPRSYKAPCSC
0 1
IRS2 (human) CyssLPRsYKAPytC S809-p
IRS2 (mouse) CYSSLPRSYKAPCSC S800
IRS2 (rat) CYSSLPRSYKAPCTC S802
C805
PRSYKAPCSCsGDND
0 9
IRS2 (human) PRsYKAPytCGGDsD Y814-p
IRS2 (mouse) PRSYKAPCSCsGDND C805
IRS2 (rat) PRSYKAPCTCGGGDN C807
S806
RSYKAPCSCsGDNDQ
0 2
IRS2 (human) RsYKAPytCGGDsDQ T815-p
IRS2 (mouse) RSYKAPCSCsGDNDQ S806
IRS2 (rat) RSYKAPCTCGGGDND T808
S808-p
YKAPCSCsGDNDQyV
0 1
IRS2 (human) YKAPytCGGDsDQyV G817
IRS2 (mouse) YKAPCSCsGDNDQyV S808-p
IRS2 (rat) YKAPCTCGGGDNDQy G810
N811
PCSCsGDNDQyVLMS
0 6
IRS2 (human) PytCGGDsDQyVLMs S820-p
IRS2 (mouse) PCSCsGDNDQyVLMS N811
IRS2 (rat) CTCGGGDNDQyVLMS N814
Y814-p
CsGDNDQyVLMSSPV
Upstream
Downstream
1 718
Effects on Modified Protein
  • molecular association, regulation
  • phosphorylation
Effects on Biological Processes:
  • signaling pathway regulation
Treatment
  • IGF-1
  • insulin
  • SB216763
IRS2 (human) CGGDsDQyVLMssPV Y823-p
IRS2 (mouse) CsGDNDQyVLMSSPV Y814-p
IRS2 (rat) GGGDNDQyVLMSSPV Y817-p
S818
NDQyVLMSSPVGRIL
0 2
IRS2 (human) sDQyVLMssPVGRIL S827-p
IRS2 (mouse) NDQyVLMSSPVGRIL S818
IRS2 (rat) NDQyVLMSSPVGRIL S821
S819
DQyVLMSSPVGRILE
0 14
IRS2 (human) DQyVLMssPVGRILE S828-p
IRS2 (mouse) DQyVLMSSPVGRILE S819
IRS2 (rat) DQyVLMSSPVGRILE S822
T883
RCRAVRPTRLsLEGL
0 1
IRS2 (human) RGRAVRPtRLsLEGL T891-p
IRS2 (mouse) RCRAVRPTRLsLEGL T883
IRS2 (rat) RCRAVRPTRLSLEGL T886
S886-p
AVRPTRLsLEGLQTL
0 4
IRS2 (human) AVRPtRLsLEGLPSL S894-p
IRS2 (mouse) AVRPTRLsLEGLQTL S886-p
IRS2 (rat) AVRPTRLSLEGLQTL S889
S895
EGLQTLPSMQEYPLP
0 1
IRS2 (human) EGLPSLPsMHEYPLP S903-p
IRS2 (mouse) EGLQTLPSMQEYPLP S895
IRS2 (rat) EGLQTLP<