Other Species / Isoforms
  DNMT1 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
V15
ARVPTLAVPAISLPD
0 12
DNMT1 (human) ARVPTLAVPAISLPD V15
DNMT1 iso2 (human) ARVPTLAVPAISLPD V15
DNMT1 (mouse) ARVPALAsPAGsLPD S15-p
DNMT1 (rat) ARVPALAsPAGSLPD S15-p
S19
TLAVPAISLPDDVRR
0 1
DNMT1 (human) TLAVPAISLPDDVRR S19
DNMT1 iso2 (human) TLAVPAISLPDDVRR S19
DNMT1 (mouse) ALAsPAGsLPDHVRR S19-p
DNMT1 (rat) ALAsPAGSLPDHVRR S19
K45
EKECVKEKLNLLHEF
0 1
DNMT1 (human) EKECVKEKLNLLHEF K45
DNMT1 iso2 (human) EKECVKEKLNLLHEF K45
DNMT1 (mouse) EKECVREKLNLLHEF K45
DNMT1 (rat) EKECVKEkLNLLHEF K45-ac
K45-ub
EKECVKEkLNLLHEF
0 1
DNMT1 (human) EKECVKEkLNLLHEF K45-ub
DNMT1 iso2 (human) EKECVKEKLNLLHEF K45
DNMT1 (mouse) EKECVREKLNLLHEF K45
DNMT1 (rat) EKECVKEKLNLLHEF K45
K58-ub
EFLQTEIkNQLCDLE
0 2
DNMT1 (human) EFLQTEIkNQLCDLE K58-ub
DNMT1 iso2 (human) EFLQTEIKNQLCDLE K58
DNMT1 (mouse) EFLQTEIKsQLCDLE K58
DNMT1 (rat) EFLQTEIKSQLCDLE K58
N59
FLQTEIkNQLCDLET
0 1
DNMT1 (human) FLQTEIkNQLCDLET N59
DNMT1 iso2 (human) FLQTEIKNQLCDLET N59
DNMT1 (mouse) FLQTEIKsQLCDLET S59-p
DNMT1 (rat) FLQTEIKSQLCDLET S59
K67-ub
QLCDLETkLRkEELS
0 1
DNMT1 (human) QLCDLETkLRkEELS K67-ub
DNMT1 iso2 (human) QLCDLETKLRKEELS K67
DNMT1 (mouse) QLCDLETKLHKEELS K67
DNMT1 (rat) QLCDLETKLHKEELS K67
K70-ub
DLETkLRkEELSEEG
0 2
DNMT1 (human) DLETkLRkEELSEEG K70-ub
DNMT1 iso2 (human) DLETKLRKEELSEEG K70
DNMT1 (mouse) DLETKLHKEELSEEG K70
DNMT1 (rat) DLETKLHKEELSEEG K70
K70-m2
DLETkLRkEELSEEG
0 1
DNMT1 (human) DLETkLRkEELSEEG K70-m2
DNMT1 iso2 (human) DLETKLRKEELSEEG K70
DNMT1 (mouse) DLETKLHKEELSEEG K70
DNMT1 (rat) DLETKLHKEELSEEG K70
K81-ub
SEEGYLAkVksLLNk
0 1
DNMT1 (human) SEEGYLAkVksLLNk K81-ub
DNMT1 iso2 (human) SEEGYLAKVKSLLNK K81
DNMT1 (mouse) SEEGYLAKVKsLLNK K81
DNMT1 (rat) SEEGYLAKVKTLLNK K81
K83-ub
EGYLAkVksLLNkDL
0 2
DNMT1 (human) EGYLAkVksLLNkDL K83-ub
DNMT1 iso2 (human) EGYLAKVKSLLNKDL K83
DNMT1 (mouse) EGYLAKVKsLLNKDL K83
DNMT1 (rat) EGYLAKVKTLLNKDL K83
S84-p
GYLAkVksLLNkDLS
0 3
DNMT1 (human) GYLAkVksLLNkDLS S84-p
DNMT1 iso2 (human) GYLAKVKSLLNKDLS S84
DNMT1 (mouse) GYLAKVKsLLNKDLS S84-p
DNMT1 (rat) GYLAKVKTLLNKDLC T84
K88-ub
kVksLLNkDLSLENG
0 2
DNMT1 (human) kVksLLNkDLSLENG K88-ub
DNMT1 iso2 (human) KVKSLLNKDLSLENG K88
DNMT1 (mouse) KVKsLLNKDLSLENG K88
DNMT1 (rat) KVKTLLNKDLCLENG K88
A125
RRVGMADANsPPKPL
0 1
DNMT1 (human) RRVGMADANsPPKPL A125
DNMT1 iso2 (human) RRVGMADANSPPKPL A125
DNMT1 (mouse) WRAEMADsNRsPRsR S122-p
DNMT1 (rat) WKAEMADSNRSPRSR S122
S127-p
VGMADANsPPKPLsk
Upstream
0 37
Kinase, in vitro:
  • CDK4 (human)
Treatment
  • EGF
  • ischemia
DNMT1 (human) VGMADANsPPKPLsk S127-p
DNMT1 iso2 (human) VGMADANSPPKPLSK S127
DNMT1 (mouse) AEMADsNRsPRsRPK R124
DNMT1 (rat) AEMADSNRSPRSRPK R124
P128
GMADANsPPKPLskP
0 8
DNMT1 (human) GMADANsPPKPLskP P128
DNMT1 iso2 (human) GMADANSPPKPLSKP P128
DNMT1 (mouse) EMADsNRsPRsRPKP S125-p
DNMT1 (rat) EMADSNRSPRSRPKP S125
P131
DANsPPKPLskPRtP
0 1
DNMT1 (human) DANsPPKPLskPRtP P131
DNMT1 iso2 (human) DANSPPKPLSKPRTP P131
DNMT1 (mouse) DsNRsPRsRPKPRGP S128-p
DNMT1 (rat) DSNRSPRSRPKPRGP S128
S133-p
NsPPKPLskPRtPRR
0 16
DNMT1 (human) NsPPKPLskPRtPRR S133-p
DNMT1 iso2 (human) NSPPKPLSKPRTPRR S133
DNMT1 (mouse) NRsPRsRPKPRGPRR P130
DNMT1 (rat) NRSPRSRPKPRGPRR P130
K134-ub
sPPKPLskPRtPRRs
0 2
DNMT1 (human) sPPKPLskPRtPRRs K134-ub
DNMT1 iso2 (human) SPPKPLSKPRTPRRS K134
DNMT1 (mouse) RsPRsRPKPRGPRRs K131
DNMT1 (rat) RSPRSRPKPRGPRRs K131
T137-p
KPLskPRtPRRsksD
0 6
DNMT1 (human) KPLskPRtPRRsksD T137-p
DNMT1 iso2 (human) KPLSKPRTPRRSkSD T137
DNMT1 (mouse) RsRPKPRGPRRsksD G134
DNMT1 (rat) RSRPKPRGPRRsKSD G134
S141-p
kPRtPRRsksDGEAk
Upstream
0 15
Regulatory protein:
  • PRP4 (human)
Treatment
  • selumetinib
  • vemurafenib
DNMT1 (human) kPRtPRRsksDGEAk S141-p
DNMT1 iso2 (human) KPRTPRRSkSDGEAK S141
DNMT1 (mouse) KPRGPRRsksDsDtL S138-p
DNMT1 (rat) KPRGPRRsKSDSETM S138-p
K142-me
PRtPRRsksDGEAkP
2 0
DNMT1 (human) PRtPRRsksDGEAkP K142-me
DNMT1 iso2 (human) PRTPRRSKSDGEAKR K142
DNMT1 (mouse) PRGPRRsksDsDtLs K139-me
DNMT1 (rat) PRGPRRsKSDSETMI K139
K142-m1
PRtPRRsksDGEAkP
Downstream
2 1
Effects on Modified Protein
  • phosphorylation
  • protein degradation
  • ubiquitination
DNMT1 (human) PRtPRRsksDGEAkP K142-m1
DNMT1 iso2 (human) PRTPRRSkSDGEAKR K142-m1
DNMT1 (mouse) PRGPRRsKsDsDtLs K139
DNMT1 (rat) PRGPRRsKSDSETMI K139
S143-p
RtPRRsksDGEAkPE
Upstream
Downstream
3 33
Effects on Modified Protein
  • enzymatic activity, inhibited
  • methylation
  • molecular association, regulation
  • protein stabilization
Effects on Biological Processes:
  • carcinogenesis, induced
Kinase, in vitro:
  • Akt1 (human)
Putative in vivo kinases:
  • Akt1 (human)
Treatment
  • angiotensin_2
  • calyculin_A
  • insulin
  • LY294002
  • peptide_agonist
  • siRNA
DNMT1 (human) RtPRRsksDGEAkPE S143-p
DNMT1 iso2 (human) RTPRRSkSDGEAKRs S143
DNMT1 (mouse) RGPRRsksDsDtLsV S140-p
DNMT1 (rat) RGPRRsKSDSETMIE S140
-
gap
0 2
DNMT1 (human) gap -
DNMT1 iso2 (human) gap -
DNMT1 (mouse) PRRsksDsDtLsVEt S142-p
DNMT1 (rat) PRRsKSDSETMIEAS S142
-
gap
0 2
DNMT1 (human) gap -
DNMT1 iso2 (human) gap -
DNMT1 (mouse) RsksDsDtLsVEtsP T144-p
DNMT1 (rat) RsKSDSETMIEASSS T144
K148-sm
sksDGEAkPEPsPsP
1 0
DNMT1 (human) sksDGEAkPEPsPsP K148-sm
DNMT1 iso2 (human) SkSDGEAKRsRDPPA K148
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
-
gap
1 3
DNMT1 (human) gap -
DNMT1 iso2 (human) gap -
DNMT1 (mouse) ksDsDtLsVEtsPss S146-p
DNMT1 (rat) gap -
-
gap
0 1
DNMT1 (human) gap -
DNMT1 iso2 (human) SDGEAKRsRDPPAsA S150-p
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
-
gap
0 1
DNMT1 (human) gap -
DNMT1 iso2 (human) RsRDPPAsAsQVtGI S156-p
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
-
gap
0 3
DNMT1 (human) gap -
DNMT1 iso2 (human) RDPPAsAsQVtGIRA S158-p
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
-
gap
0 1
DNMT1 (human) gap -
DNMT1 iso2 (human) PAsAsQVtGIRAEPs T161-p
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
-
gap
0 1
DNMT1 (human) gap -
DNMT1 iso2 (human) gap -
DNMT1 (mouse) sDtLsVEtsPssVAT T149-p
DNMT1 (rat) DSETMIEASSSSVAT A148
S152-p
GEAkPEPsPsPRITR
0 21
DNMT1 (human) GEAkPEPsPsPRITR S152-p
DNMT1 iso2 (human) tGIRAEPsPSPRITR S168-p
DNMT1 (mouse) DtLsVEtsPssVATR S150-p
DNMT1 (rat) SETMIEASSSSVATR S149
S154-p
AkPEPsPsPRITRkS
Upstream
Downstream
2 30
Effects on Modified Protein
  • enzymatic activity, induced
  • protein stabilization
Kinase, in vitro:
  • CDK1 (human)
  • CDK2 (human)
  • CDK5 (human)
Putative in vivo kinases:
  • CDK5 (human)
Treatment
  • angiotensin_2
  • sodium_phosphate
DNMT1 (human) AkPEPsPsPRITRkS S154-p
DNMT1 iso2 (human) IRAEPsPSPRITRKS S170
DNMT1 (mouse) LsVEtsPssVATRRT S152-p
DNMT1 (rat) TMIEASSSSVATRRT S151
P155
kPEPsPsPRITRkST
0 1
DNMT1 (human) kPEPsPsPRITRkST P155
DNMT1 iso2 (human) RAEPsPSPRITRKST P171
DNMT1 (mouse) sVEtsPssVATRRTT S153-p
DNMT1 (rat) MIEASSSSVATRRTT S152
K160-ac
PsPRITRkSTRQttI
1 0
DNMT1 (human) PsPRITRkSTRQttI K160-ac
DNMT1 iso2 (human) PSPRITRKSTRQTTI K176
DNMT1 (mouse) PssVATRRTTRQTTI R158
DNMT1 (rat) SSSVATRRTTRQTTI R157
T165-p
TRkSTRQttItSHFA
0 1
DNMT1 (human) TRkSTRQttItSHFA T165-p
DNMT1 iso2 (human) TRKSTRQTTITSHFA T181
DNMT1 (mouse) TRRTTRQTTITAHFT T163
DNMT1 (rat) TRRTTRQTTITSHFK T162
T166-p
RkSTRQttItSHFAk
0 3
DNMT1 (human) RkSTRQttItSHFAk T166-p
DNMT1 iso2 (human) RKSTRQTTITSHFAK T182
DNMT1 (mouse) RRTTRQTTITAHFTK T164
DNMT1 (rat) RRTTRQTTITSHFKG T163
T168-p
STRQttItSHFAkGP
Upstream
0 1
Treatment
  • CXCL12
DNMT1 (human) STRQttItSHFAkGP T168-p
DNMT1 iso2 (human) STRQTTITSHFAKGP T184
DNMT1 (mouse) TTRQTTITAHFTKGP T166
DNMT1 (rat) TTRQTTITSHFKGPA T165
K173-ac
tItSHFAkGPAKRKP
Upstream
0 1
Treatment
  • MS275
DNMT1 (human) tItSHFAkGPAKRKP K173-ac
DNMT1 iso2 (human) TITSHFAKGPAKRKP K189
DNMT1 (mouse) TITAHFTKGPTKRKP K171
DNMT1 (rat) TTITSHFKGPAKRKP K169
K173-ub
tItSHFAkGPAKRKP
0 1
DNMT1 (human) tItSHFAkGPAKRKP K173-ub
DNMT1 iso2 (human) TITSHFAKGPAKRKP K189
DNMT1 (mouse) TITAHFTKGPTKRKP K171
DNMT1 (rat) TTITSHFKGPAKRKP K169
S184
KRKPQEESERAksDE
0 1
DNMT1 (human) KRKPQEESERAksDE S184
DNMT1 iso2 (human) KRKPQEESERAKSDE S200
DNMT1 (mouse) KRKPKEEsEEGNsAE S182-p
DNMT1 (rat) KRKPKEDSEKGNANE S180
K188-ac
QEESERAksDEsIkE
1 0
DNMT1 (human) QEESERAksDEsIkE K188-ac
DNMT1 iso2 (human) QEESERAKSDESIKE K204
DNMT1 (mouse) KEEsEEGNsAEsAAE N186
DNMT1 (rat) KEDSEKGNANESAAE N184
S189-p
EESERAksDEsIkEE
0 8
DNMT1 (human) EESERAksDEsIkEE S189-p
DNMT1 iso2 (human) EESERAKSDESIKEE S205
DNMT1 (mouse) EEsEEGNsAEsAAEE S187-p
DNMT1 (rat) EDSEKGNANESAAEE A185
S192-p
ERAksDEsIkEEDKD
0 7
DNMT1 (human) ERAksDEsIkEEDKD S192-p
DNMT1 iso2 (human) ERAKSDESIKEEDKD S208
DNMT1 (mouse) EEGNsAEsAAEERDQ S190-p
DNMT1 (rat) EKGNANESAAEERDQ S188
K194-sm
AksDEsIkEEDKDQD
1 0
DNMT1 (human) AksDEsIkEEDKDQD K194-sm
DNMT1 iso2 (human) AKSDESIKEEDKDQD K210
DNMT1 (mouse) GNsAEsAAEERDQDK A192
DNMT1 (rat) GNANESAAEERDQDK A190
T208-p
DEKRRRVtsRERVAR
Upstream
0 3
Treatment
  • nocodazole
DNMT1 (human) DEKRRRVtsRERVAR T208-p
DNMT1 iso2 (human) DEKRRRVTSRERVAR T224
DNMT1 (mouse) KKRRVVDTESGAAAA T206
DNMT1 (rat) KKRRVAGTESRASRA T204
S209-p
EKRRRVtsRERVARP
Upstream
0 10
Treatment
  • nocodazole
DNMT1 (human) EKRRRVtsRERVARP S209-p
DNMT1 iso2 (human) EKRRRVTSRERVARP S225
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
S227-p
EEPERAKsGTRTEKE
0 2
DNMT1 (human) EEPERAKsGTRTEKE S227-p
DNMT1 iso2 (human) EEPERAKSGTRTEKE S243
DNMT1 (mouse) EKLEEVTAGTQLGPE A222
DNMT1 (rat) EKPERVRPGTQLCQE P223
R244
RDEKEEKRLRsQTKE
0 1
DNMT1 (human) RDEKEEKRLRsQTKE R244
DNMT1 iso2 (human) RDEKEEKRLRSQTKE R260
DNMT1 (mouse) EQEDDNRsLRRHtRE S240-p
DNMT1 (rat) GEQEDDRRPRRQTRE R240
S247-p
KEEKRLRsQTKEPTP
0 1
DNMT1 (human) KEEKRLRsQTKEPTP S247-p
DNMT1 iso2 (human) KEEKRLRSQTKEPTP S263
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
T249
EKRLRsQTKEPTPKQ
0 11
DNMT1 (human) EKRLRsQTKEPTPKQ T249
DNMT1 iso2 (human) EKRLRSQTKEPTPKQ T265
DNMT1 (mouse) NRsLRRHtRELsLRR T245-p
DNMT1 (rat) DRRPRRQTRELASRR T245
T253
RsQTKEPTPKQKLkE
0 1
DNMT1 (human) RsQTKEPTPKQKLkE T253
DNMT1 iso2 (human) RSQTKEPTPKQKLKE T269
DNMT1 (mouse) RRHtRELsLRRKsKE S249-p
DNMT1 (rat) RRQTRELASRRKsRE A249
L258
EPTPKQKLkEEPDRE
0 5
DNMT1 (human) EPTPKQKLkEEPDRE L258
DNMT1 iso2 (human) EPTPKQKLKEEPDRE L274
DNMT1 (mouse) ELsLRRKsKEDPDRE S254-p
DNMT1 (rat) ELASRRKsREDPDRE S254-p
K259-ac
PTPKQKLkEEPDREA
1 0
DNMT1 (human) PTPKQKLkEEPDREA K259-ac
DNMT1 iso2 (human) PTPKQKLKEEPDREA K275
DNMT1 (mouse) LsLRRKsKEDPDREA K255
DNMT1 (rat) LASRRKsREDPDREA R255
K259-sm
PTPKQKLkEEPDREA
0 1
DNMT1 (human) PTPKQKLkEEPDREA K259-sm
DNMT1 iso2 (human) PTPKQKLKEEPDREA K275
DNMT1 (mouse) LsLRRKsKEDPDREA K255
DNMT1 (rat) LASRRKsREDPDREA R255
S288-p
KDEKKHRsQPKDLAA
0 6
DNMT1 (human) KDEKKHRsQPKDLAA S288-p
DNMT1 iso2 (human) KDEKKHRSQPKDLAA S304
DNMT1 (mouse) KRSSRPRsQPRDPAA S285-p
DNMT1 (rat) KRSSRPRSQPRDLAT S285
N308
EKEPEKVNPQIsDEK
0 1
DNMT1 (human) EKEPEKVNPQIsDEK N308
DNMT1 iso2 (human) EKEPEKVNPQISDEK N324
DNMT1 (mouse) EAEPEQVAPEtPEDR A305
DNMT1 (rat) KEEVEQItPEPPEGK T304-p
-
gap
0 10
DNMT1 (human) gap -
DNMT1 iso2 (human) gap -
DNMT1 (mouse) PEQVAPEtPEDRDED T308-p
DNMT1 (rat) gap -
S312-p
EKVNPQIsDEKDEDE
0 6
DNMT1 (human) EKVNPQIsDEKDEDE S312-p
DNMT1 iso2 (human) EKVNPQISDEKDEDE S328
DNMT1 (mouse) gap -
DNMT1 (rat) gap -
T328-p
EEKRRKTtPKEPTEk
0 1
DNMT1 (human) EEKRRKTtPKEPTEk T328-p
DNMT1 iso2 (human) EEKRRKTTPKEPTEK T344
DNMT1 (mouse) EEKRRKTTRKKLESH T325
DNMT1 (rat) EEKRRKTTRKKPEPL T324
K335-ac
tPKEPTEkkMARAKT
0 1
DNMT1 (human) tPKEPTEkkMARAKT K335-ac
DNMT1 iso2 (human) TPKEPTEKKMARAKT K351
DNMT1 (mouse) PVQSRSERKAAQSKS R342
DNMT1 (rat) PVQSRVERKASQGKA R341
K336-ub
PKEPTEkkMARAKTV
0 1
DNMT1 (human) PKEPTEkkMARAKTV K336-ub
DNMT1 iso2 (human) PKEPTEKKMARAKTV K352
DNMT1 (mouse) VQSRSERKAAQSKSV K343
DNMT1 (rat) VQSRVERKASQGKAS K342
S346-p
RAKTVMNsKTHPPKC
0 1
DNMT1 (human) RAKTVMNsKTHPPKC S346-p
DNMT1 iso2 (human) RAKTVMNSKTHPPKC S362
DNMT1 (mouse) AQSKSVIPKINSPKC P352
DNMT1 (rat) QGKASAIPKLNPPQC P352
Y359-p
KCIQCGQyLDDPDLk
0 2
DNMT1 (human) KCIQCGQyLDDPDLk Y359-p
DNMT1 iso2 (human) KCIQCGQYLDDPDLK Y375
DNMT1 (mouse) KCPECGQHLDDPNLK H365
DNMT1 (rat) QCPECGQYLDDPDLK Y365
K366-ac
yLDDPDLkYGQHPPD
1 0
DNMT1 (human) yLDDPDLkYGQHPPD K366-ac
DNMT1 iso2 (human) YLDDPDLKYGQHPPD K382
DNMT1 (mouse) HLDDPNLKYQQHPED K372
DNMT1 (rat) YLDDPDLKYQQHPVD K372
K385-ub
PQMLTNEkLSIFDAN
0 3
DNMT1 (human) PQMLTNEkLSIFDAN K385-ub
DNMT1 iso2 (human) PQMLTNEKLSIFDAN K401
DNMT1 (mouse) PQMLTSEKLSIYDsT K391
DNMT1 (rat) PQMLTNEALSVFDSN A391
A391
EkLSIFDANEsGFEs
0 1
DNMT1 (human) EkLSIFDANEsGFEs A391
DNMT1 iso2 (human) EKLSIFDANESGFES A407
DNMT1 (mouse) EKLSIYDsTSTWFDT S397-p
DNMT1 (rat) EALSVFDSNSSWFET S397
S394-p
SIFDANEsGFEsyEA
Upstream
0 20
Treatment
  • BI2536
  • MLN8054
  • nocodazole
DNMT1 (human) SIFDANEsGFEsyEA S394-p
DNMT1 iso2 (human) SIFDANESGFESYEA S410
DNMT1 (mouse) SIYDsTSTWFDTYED T400
DNMT1 (rat) SVFDSNSSWFETYDS S400
S398-p
ANEsGFEsyEALPQH
0 10
DNMT1 (human) ANEsGFEsyEALPQH S398-p
DNMT1 iso2 (human) ANESGFESYEALPQH S414
DNMT1 (mouse) sTSTWFDTYEDSPMH T404
DNMT1 (rat) SNSSWFETYDSSPMH T404
Y399-p
NEsGFEsyEALPQHK
0 24
DNMT1 (human) NEsGFEsyEALPQHK Y399-p
DNMT1 iso2 (human) NESGFESYEALPQHK Y415
DNMT1 (mouse) TSTWFDTYEDSPMHR Y405
DNMT1 (rat) NSSWFETYDSSPMHK Y405
S492
EYILMDPSPEYAPIF
0 1
DNMT1 (human) EYILMDPSPEYAPIF S492
DNMT1 iso2 (human) EYILMDPSPEYAPIF S508
DNMT1 (mouse) EYILMEPsKEYEPIF S498-p
DNMT1 (rat) EYFLMEPSPEYAPIF S498
S509
MQEKIYISKIVVEFL
2 2
DNMT1 (human) MQEKIYISKIVVEFL S509
DNMT1 iso2 (human) MQEKIYISKIVVEFL S525
DNMT1 (mouse) MQEKIYIsKIVVEFL S515-p
DNMT1 (rat) MQEKIYISKIVVEFL S515
S549-p
LNRFTEDsLLRHAQF
0 1
DNMT1 (human) LNRFTEDsLLRHAQF S549-p
DNMT1 iso2 (human) LNRFTEDSLLRHAQF S565
DNMT1 (mouse) VNRFTEDSLLRHAQF S555
DNMT1 (rat) VNRFTEDSLLRHAQF S555
K586-ub
PCMRDLIkLAGVtLG
0 11
DNMT1 (human) PCMRDLIkLAGVtLG K586-ub
DNMT1 iso2 (human) PCMRDLIKLAGVTLG K602
DNMT1 (mouse) PCMRALIHLAGVsLG H592
DNMT1 (rat) PCMRSLIHLAGVSLG H592
T591-p
LIkLAGVtLGQRRAQ
0 3
DNMT1 (human) LIkLAGVtLGQRRAQ T591-p
DNMT1 iso2 (human) LIKLAGVTLGQRRAQ T607
DNMT1 (mouse) LIHLAGVsLGQRRAt S597-p
DNMT1 (rat) LIHLAGVSLGQRRAT S597
Q598
tLGQRRAQARRQTIR
0 1
DNMT1 (human) tLGQRRAQARRQTIR Q598
DNMT1 iso2 (human) TLGQRRAQARRQTIR Q614
DNMT1 (mouse) sLGQRRAtRRVMGAt T604-p
DNMT1 (rat) SLGQRRATRRTVINS T604
T608
RQTIRHSTREKDRGP
0 1
DNMT1 (human) RQTIRHSTREKDRGP T608
DNMT1 iso2 (human) RQTIRHSTREKDRGP T624
DNMT1 (mouse) tRRVMGAtkEKDKAP T611-p
DNMT1 (rat) RRTVINSAKVKRKGP A612
R609
QTIRHSTREKDRGPT
0 1
DNMT1 (human) QTIRHSTREKDRGPT R609
DNMT1 iso2 (human) QTIRHSTREKDRGPT R625
DNMT1 (mouse) RRVMGAtkEKDKAPT K612-ub
DNMT1 (rat) RTVINSAKVKRKGPT K613
K622
PTKATTTKLVYQIFD
0 2
DNMT1 (human) PTKATTTKLVYQIFD K622
DNMT1 iso2 (human) PTKATTTKLVYQIFD K638
DNMT1 (mouse) PTKATTTkLVYQIFD K625-ub
DNMT1 (rat) PTKATTTKLVYQIFD K626
K638-ub
FFAEQIEkDDREDkE
0 1
DNMT1 (human) FFAEQIEkDDREDkE K638-ub
DNMT1 iso2 (human) FFAEQIEKDDREDKE K654
DNMT1 (mouse) FFSEQIEKYDKEDKE K641
DNMT1 (rat) FFSEQIEKDDKEDKE K642
K644-ub
EkDDREDkENAFKRR
0 1
DNMT1 (human) EkDDREDkENAFKRR K644-ub
DNMT1 iso2 (human) EKDDREDKENAFKRR K660
DNMT1 (mouse) EKYDKEDKENAMKRR K647
DNMT1 (rat) EKDDKEDKENTMKRR K648
K666-ub
CQQPECGkCkACKDM
0 15
DNMT1 (human) CQQPECGkCkACKDM K666-ub
DNMT1 iso2 (human) CQQPECGKCKACKDM K682
DNMT1 (mouse) CQQPECGkCkACkDM K669-ub
DNMT1 (rat) CQQPECGKCKACKDM K670
K668-ub
QPECGkCkACKDMVk
0 5
DNMT1 (human) QPECGkCkACKDMVk K668-ub
DNMT1 iso2 (human) QPECGKCKACKDMVK K684
DNMT1 (mouse) QPECGkCkACkDMVk K671-ub
DNMT1 (rat) QPECGKCKACKDMVK K672
K671
CGkCkACKDMVkFGG
0 3
DNMT1 (human) CGkCkACKDMVkFGG K671
DNMT1 iso2 (human) CGKCKACKDMVKFGG K687
DNMT1 (mouse) CGkCkACkDMVkFGG K674-ub
DNMT1 (rat) CGKCKACKDMVKFGG K675
K675-ub
kACKDMVkFGGSGRS
0 8
DNMT1 (human) kACKDMVkFGGSGRS K675-ub
DNMT1 iso2 (human) KACKDMVKFGGSGRS K691
DNMT1 (mouse) kACkDMVkFGGTGRS K678-ub
DNMT1 (rat) KACKDMVKFGGTGRS K679
K675-sm
kACKDMVkFGGSGRS
1 0
DNMT1 (human) kACKDMVkFGGSGRS K675-sm
DNMT1 iso2 (human) KACKDMVKFGGSGRS K691
DNMT1 (mouse) kACkDMVKFGGTGRS K678
DNMT1 (rat) KACKDMVKFGGTGRS K679
P710
EEVDDNIPEMPsPkK
0 1
DNMT1 (human) EEVDDNIPEMPsPkK P710
DNMT1 iso2 (human) EEVDDNIPEMPsPKK P726
DNMT1 (mouse) EEADDDVsEMPsPKK S713-p
DNMT1 (rat) EEADDDIPELPsPKK P714
S714-p
DNIPEMPsPkKMHQG
Upstream
3 76
Putative in vivo kinases:
  • mTOR (human)
Regulatory protein:
  • PRP4 (human)
Treatment
  • cisplatin
  • dasatinib
  • Torin1
DNMT1 (human) DNIPEMPsPkKMHQG S714-p
DNMT1 iso2 (human) DNIPEMPsPKKMHQG S730-p
DNMT1 (mouse) DDVsEMPsPKKLHQG S717-p
DNMT1 (rat) DDIPELPsPKKLHQG S718-p
K716-ub
IPEMPsPkKMHQGKK
0 1
DNMT1 (human) IPEMPsPkKMHQGKK K716-ub
DNMT1 iso2 (human) IPEMPsPKKMHQGKK K732
DNMT1 (mouse) VsEMPsPKKLHQGKK K719
DNMT1 (rat) IPELPsPKKLHQGKK K720
S732-p
KQNKNRIsWVGEAVk
Upstream
0 28
Treatment
  • BI_4834
  • EGF
DNMT1 (human) KQNKNRIsWVGEAVk S732-p
DNMT1 iso2 (human) KQNKNRISWVGEAVK S748
DNMT1 (mouse) KQNKDRISWLGQPMK S735
DNMT1 (rat) KQNKDRISWLGEPVK S736
K739-sm
sWVGEAVkTDGKKSY
1 0
DNMT1 (human) sWVGEAVkTDGKKSY K739-sm
DNMT1 iso2 (human) SWVGEAVKTDGKKSY K755
DNMT1 (mouse) SWLGQPMKIEENRTY K742
DNMT1 (rat) SWLGEPVKIEENRTY K743
K749-ac
GKKSYYKkVCIDAET
1 0
DNMT1 (human) GKKSYYKkVCIDAET K749-ac
DNMT1 iso2 (human) GKKSYYKKVCIDAET K765
DNMT1 (mouse) ENRTYYQKVSIDEEM K752
DNMT1 (rat) ENRTYYWKVSIDEET K753
S878-p
QDYARFEsPPktQPT
0 4
DNMT1 (human) QDYARFEsPPktQPT S878-p
DNMT1 iso2 (human) QDYARFESPPKTQPT S894
DNMT1 (mouse) QEYARFESPPKTQPT S882
DNMT1 (rat) QDYARFESPPKTQPA S882
K881-ub
ARFEsPPktQPTEDN
0 2
DNMT1 (human) ARFEsPPktQPTEDN K881-ub
DNMT1 iso2 (human) ARFESPPKTQPTEDN K897
DNMT1 (mouse) ARFESPPKTQPTEDN K885
DNMT1 (rat) ARFESPPKTQPAEDN K885
T882-p
RFEsPPktQPTEDNk
0 1
DNMT1 (human) RFEsPPktQPTEDNk T882-p
DNMT1 iso2 (human) RFESPPKTQPTEDNK T898
DNMT1 (mouse) RFESPPKTQPTEDNK T886
DNMT1 (rat) RFESPPKTQPAEDNK T886
K889-ub
tQPTEDNkFkFCVSC
0 1
DNMT1 (human) tQPTEDNkFkFCVSC K889-ub
DNMT1 iso2 (human) TQPTEDNKFKFCVSC K905
DNMT1 (mouse) TQPTEDNKHKFCLSC K893
DNMT1 (rat) TQPAEDNKHKFCLSC K893
K891-ac
PTEDNkFkFCVSCAR
1 0
DNMT1 (human) PTEDNkFkFCVSCAR K891-ac
DNMT1 iso2 (human) PTEDNKFKFCVSCAR K907
DNMT1 (mouse) PTEDNKHKFCLSCIR K895
DNMT1 (rat) PAEDNKHKFCLSCIR K895
S919-p
EQLEDLDsRVLYYSA
0 1
DNMT1 (human) EQLEDLDsRVLYYSA S919-p
DNMT1 iso2 (human) EQLEDLDSRVLYYSA S935
DNMT1 (mouse) EQIEEVDGRVYCSSI G923
DNMT1 (rat) EQLEEVDGRVYCSSI G923
K928-ub
VLYYSATkNGILYRV
Upstream
0 2
Treatment
  • MG132
DNMT1 (human) VLYYSATkNGILYRV K928-ub
DNMT1 iso2 (human) VLYYSATKNGILYRV K944
DNMT1 (mouse) VYCSSITKNGVVYRL K932
DNMT1 (rat) VYCSSITKNGVVYRL K932
S954-p
TFNIKLSsPVkRPRk
Upstream
0 13
Kinase, in vitro:
  • CDK4 (human)
DNMT1 (human) TFNIKLSsPVkRPRk S954-p
DNMT1 iso2 (human) TFNIKLSSPVKRPRK S970
DNMT1 (mouse) TFNIKVAsPVKRPKK S958-p
DNMT1 (rat) TFNIKMAsPMKRSKR S958-p
K957-ac
IKLSsPVkRPRkEPV
1 0
DNMT1 (human) IKLSsPVkRPRkEPV K957-ac
DNMT1 iso2 (human) IKLSSPVKRPRKEPV K973
DNMT1 (mouse) IKVAsPVKRPKKDPV K961
DNMT1 (rat) IKMAsPMKRSKRDPV K961
K957-ub
IKLSsPVkRPRkEPV
0 1