Other Species / Isoforms
  GSK3A (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
S2-p
______MsGGGPsGG
0 12
GSK3A (human) ______MsGGGPsGG S2-p
GSK3A (mouse) ______MsGGGPsGG S2-p
GSK3A (rat) ______MsGGGPSGG S2-p
GSK3A (cow) ______MSGGAPSGG S2
S7-p
_MsGGGPsGGGPGGs
0 3
GSK3A (human) _MsGGGPsGGGPGGs S7-p
GSK3A (mouse) _MsGGGPsGGGPGGs S7-p
GSK3A (rat) _MsGGGPSGGGPGGS S7
GSK3A (cow) _MSGGAPSGGGPGGS S7
S14-p
sGGGPGGsGrARtss
0 3
GSK3A (human) sGGGPGGsGrARtss S14-p
GSK3A (mouse) sGGGPGGsGRARtss S14-p
GSK3A (rat) SGGGPGGSGRARtss S14
GSK3A (cow) SGGGPGGSGRARTSs S14
R16-m1
GGPGGsGrARtssFA
0 1
GSK3A (human) GGPGGsGrARtssFA R16-m1
GSK3A (mouse) GGPGGsGRARtssFA R16
GSK3A (rat) GGPGGSGRARtssFA R16
GSK3A (cow) GGPGGSGRARTSsFA R16
T19-p
GGsGrARtssFAEPG
Upstream
1 78
Treatment
  • gefitinib
  • imatinib
  • Su11274
  • wortmannin
GSK3A (human) GGsGrARtssFAEPG T19-p
GSK3A (mouse) GGsGRARtssFAEPG T19-p
GSK3A (rat) GGSGRARtssFAEPG T19-p
GSK3A (cow) GGSGRARTSsFAEPG T19
S20-p
GsGrARtssFAEPGG
0 51
GSK3A (human) GsGrARtssFAEPGG S20-p
GSK3A (mouse) GsGRARtssFAEPGG S20-p
GSK3A (rat) GSGRARtssFAEPGG S20-p
GSK3A (cow) GSGRARTSsFAEPGG S20
S21-p
sGrARtssFAEPGGG
Upstream
Downstream
137 298
GSK3A (human)
S21-p
GSK3A (mouse)
S21-p
GSK3A (rat)
S21-p
GSK3A (cow)
S21-p
Effects on Modified Protein
  • enzymatic activity, inhibited
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • apoptosis, induced
  • apoptosis, inhibited
Kinase, in vitro:
  • Akt1 (human)
  • PKACA (human)
  • PKCA (human)
  • PKCB iso2 (human)
  • PKCD (human)
  • PKCG (human)
  • PKCH (human)
  • RSK2 (human)
Putative in vivo kinases:
  • IKKE (human)
  • PKACA (human)
  • PKCA (human)
  • PKCB (human)
  • PKCH (human)
Regulatory protein:
  • Akt1 (human)
  • Akt2 (human)
  • Akt3 (human)
  • AR (human)
  • BRAF (human)
  • CYR61 (human)
  • E4 (adenovirus)
  • GRP78 (human)
  • GSK3A (human)
  • IEX-1 (human)
  • IKKE (human)
  • ILK (human)
  • ILKAP (human)
  • IRAK4 (human)
  • NRas (human)
  • OSBPL8 (mouse)
  • p16-INK4A (human)
  • PHLPP (human)
  • PHLPP2 (human)
  • PPP1R2 (human)
  • PTEN (human)
  • RPS23 (mouse)
Treatment
  • 2-deoxyglucose
  • Akt-I-1
  • Akt_inhibitor_IV
  • amino_acids
  • anti-Akt1
  • anti-CD28
  • anti-CD3
  • anti-CTLA-4
  • anti-ICOS
  • B7
  • BAPTA-AM
  • cAMP_analog
  • celecoxib
  • cisplatin
  • colforsin
  • collagen
  • conditioned medium
  • convulxin
  • depolarization
  • EGF
  • enzalutamide
  • enzastaurin
  • Epo
  • exercise
  • fibronectin
  • fMLP
  • gefitinib
  • geldanamycin
  • GF109203X
  • glucose
  • Go_6976
  • Go_6983
  • H-7
  • H-89
  • H2O2
  • HA-1004
  • HB-EGF
  • HGF
  • hypoxia
  • IGF-1
  • IL-1a
  • IL-6
  • imatinib
  • insulin
  • IP(6)
  • isoproterenol
  • kenpaullone
  • KN-62
  • KP-372-1
  • linoleic_acid
  • lithium
  • low_K(+)
  • LPA
  • LPS
  • LY2064827
  • LY294002
  • ML-9
  • oleic_acid
  • PD98059
  • PKI-402
  • poly-L-lysine
  • rapamycin
  • retinoic_acid
  • Ro31-8220
  • rottlerin
  • RRD-251
  • SB203580
  • SCF
  • Sem3A
  • serum
  • serum_withdrawal
  • SII_angiotensin_2
  • siRNA
  • SN-50
  • sphingosine_1-phosphate
  • staurosporine
  • Su11274
  • thapsigargin
  • thrombin
  • TNF
  • TRAIL
  • transplatin
  • tunicamycin
  • U71322
  • UCN-01
  • vanadate
  • wortmannin
GSK3A (human) sGrARtssFAEPGGG S21-p
GSK3A (mouse) sGRARtssFAEPGGG S21-p
GSK3A (rat) SGRARtssFAEPGGG S21-p
GSK3A (cow) SGRARTSsFAEPGGG S21-p
S39-p
GGGGPGGsAsGPGGt
0 8
GSK3A (human) GGGGPGGsAsGPGGt S39-p
GSK3A (mouse) GGGGPGGsAsGPGGT S39-p
GSK3A (rat) GGGGPGGSASGPGGT S39
GSK3A (cow) GGGGPGGSASGPGGS S39
S41-p
GGPGGsAsGPGGtGG
Upstream
0 7
Treatment
  • MG132_withdrawal
GSK3A (human) GGPGGsAsGPGGtGG S41-p
GSK3A (mouse) GGPGGsAsGPGGTGG S41-p
GSK3A (rat) GGPGGSASGPGGTGG S41
GSK3A (cow) GGPGGSASGPGGSGG S41
T46-p
sAsGPGGtGGGKAsV
0 4
GSK3A (human) sAsGPGGtGGGKAsV T46-p
GSK3A (mouse) sAsGPGGTGGGKASV T46
GSK3A (rat) SASGPGGTGGGKASV T46
GSK3A (cow) SASGPGGSGGGKTSV S46
S52-p
GtGGGKAsVGAMGGG
Upstream
0 2
Treatment
  • MEK_inhibitor_I
GSK3A (human) GtGGGKAsVGAMGGG S52-p
GSK3A (mouse) GTGGGKASVGAMGGG S52
GSK3A (rat) GTGGGKASVGAMGGG S52
GSK3A (cow) GSGGGKTSVGAMGGG S52
S63-p
MGGGVGAsSSGGGPG
Upstream
0 3
Treatment
  • MEK_inhibitor_I
GSK3A (human) MGGGVGAsSSGGGPG S63-p
GSK3A (mouse) MGGGVGASSSGGGPS S63
GSK3A (rat) MGGGVGASSSGGGPS S63
GSK3A (cow) MGGGVGASSSGGGPG S63
S72-p
SGGGPGGsGGGGsGG
0 2
GSK3A (human) SGGGPGGsGGGGsGG S72-p
GSK3A (mouse) SGGGPSGsGGGGsGG S72-p
GSK3A (rat) SGGGPSGSGGGGSGG S72
GSK3A (cow) SGGGPGGSGGGGSGG S72
S77-p
GGsGGGGsGGPGAGT
0 2
GSK3A (human) GGsGGGGsGGPGAGT S77-p
GSK3A (mouse) SGsGGGGsGGPGAGt S77-p
GSK3A (rat) SGSGGGGSGGPGAGT S77
GSK3A (cow) GGSGGGGSGGPGAGT S77
T84
sGGPGAGTSFPPPGV
0 1
GSK3A (human) sGGPGAGTSFPPPGV T84
GSK3A (mouse) sGGPGAGtsFPPPGV T84-p
GSK3A (rat) SGGPGAGTSFPPPGV T84
GSK3A (cow) SGGPGAGTSFPPPGV T84
S85
GGPGAGTSFPPPGVK
0 1
GSK3A (human) GGPGAGTSFPPPGVK S85
GSK3A (mouse) GGPGAGtsFPPPGVK S85-p
GSK3A (rat) GGPGAGTSFPPPGVK S85
GSK3A (cow) GGPGAGTSFPPPGVK S85
S97-p
GVKLGRDsGKVTTVV
Upstream
0 3
Treatment
  • MG132_withdrawal
GSK3A (human) GVKLGRDsGKVTTVV S97-p
GSK3A (mouse) GVKLGRDSGKVTTVV S97
GSK3A (rat) GVKLGRDSGKVTTVV S97
GSK3A (cow) GVKLGRDSGKVTTVV S97
K123-ac
EVAYTDIkVIGNGSF
0 1
GSK3A (human) EVAYTDIkVIGNGSF K123-ac
GSK3A (mouse) EVAYTDIKVIGNGSF K123
GSK3A (rat) EVAYTDIKVIGNGSF K123
GSK3A (cow) EVAYTDIKVIGSGSF K123
Y134-p
NGSFGVVyQARLAEt
0 26
GSK3A (human) NGSFGVVyQARLAEt Y134-p
GSK3A (mouse) NGSFGVVyQARLAET Y134-p
GSK3A (rat) NGSFGVVyQARLAET Y134-p
GSK3A (cow) SGSFGVVYQARLADT Y134
T141-p
yQARLAEtRELVAIK
0 1
GSK3A (human) yQARLAEtRELVAIK T141-p
GSK3A (mouse) yQARLAETRELVAIK T141
GSK3A (rat) yQARLAETRELVAIK T141
GSK3A (cow) YQARLADTRELVAIK T141
Y197-p
YLNLVLEyVPETVYR
0 3
GSK3A (human) YLNLVLEyVPETVYR Y197-p
GSK3A (mouse) YLNLVLEYVPETVYR Y197
GSK3A (rat) YLNLVLEYVPETVYR Y197
GSK3A (cow) YLNLVLEYVPETVYR Y197
K246-ub
GVCHRDIkPQNLLVD
0 1
GSK3A (human) GVCHRDIkPQNLLVD K246-ub
GSK3A (mouse) GVCHRDIKPQNLLVD K246
GSK3A (rat) GVCHRDIKPQNLLVD K246
GSK3A (cow) GVCHRDIKPQNLLVD K246
K260-ub
DPDTAVLkLCDFGSA
0 1
GSK3A (human) DPDTAVLkLCDFGSA K260-ub
GSK3A (mouse) DPDTAVLKLCDFGSA K260
GSK3A (rat) DPDTAVLKLCDFGSA K260
GSK3A (cow) DPDTAVLKLCDFGSA K260
K268-ub
LCDFGSAkQLVRGEP
0 9
GSK3A (human) LCDFGSAkQLVRGEP K268-ub
GSK3A (mouse) LCDFGSAkQLVRGEP K268-ub
GSK3A (rat) LCDFGSAKQLVRGEP K268
GSK3A (cow) LCDFGSAKQLVRGEP K268
S278-p
VRGEPNVsyICsRyy
Upstream
1 1286
Regulatory protein:
  • PPP2CA (human)
Treatment
  • IL-3
  • serum
GSK3A (human) VRGEPNVsyICsRyy S278-p
GSK3A (mouse) VRGEPNVsyICsRYY S278-p
GSK3A (rat) VRGEPNVsyICsRyY S278-p
GSK3A (cow) VRGEPNVSYICSRYY S278
Y279-p
RGEPNVsyICsRyyR
Upstream
Downstream
18 4312
Effects on Modified Protein
  • enzymatic activity, induced
Effects on Biological Processes:
  • apoptosis, altered
Putative in vivo kinases:
  • GSK3A (human)
Regulatory protein:
  • PRP4 (human)
Treatment
  • 705701
  • 708244
  • 709125
  • anisomycin
  • anti-CD28
  • anti-CD3
  • CXCL12
  • cycloheximide
  • enzastaurin
  • genistein
  • indirubin
  • kenpaullone
  • lithium
  • LY2064827
  • NMDA
  • PP2
  • purvalanol
  • retinoic_acid
  • RRD-251
  • SII_angiotensin_2
  • staurosporine
  • U0126
GSK3A (human) RGEPNVsyICsRyyR Y279-p
GSK3A (mouse) RGEPNVsyICsRYYR Y279-p
GSK3A (rat) RGEPNVsyICsRyYR Y279-p
GSK3A (cow) RGEPNVSYICSRYYR Y279
S282-p
PNVsyICsRyyRAPE
Upstream
0 1142
Treatment
  • U0126
GSK3A (human) PNVsyICsRyyRAPE S282-p
GSK3A (mouse) PNVsyICsRYYRAPE S282-p
GSK3A (rat) PNVsyICsRyYRAPE S282-p
GSK3A (cow) PNVSYICSRYYRAPE S282
Y284-p
VsyICsRyyRAPELI
0 109
GSK3A (human) VsyICsRyyRAPELI Y284-p
GSK3A (mouse) VsyICsRYYRAPELI Y284
GSK3A (rat) VsyICsRyYRAPELI Y284-p
GSK3A (cow) VSYICSRYYRAPELI Y284
Y285-p
syICsRyyRAPELIF
0 6
GSK3A (human) syICsRyyRAPELIF Y285-p
GSK3A (mouse) syICsRYYRAPELIF Y285
GSK3A (rat) syICsRyYRAPELIF Y285
GSK3A (cow) SYICSRYYRAPELIF Y285
K355-ub
NPNYTEFkFPQIKAH
0 5
GSK3A (human) NPNYTEFkFPQIKAH K355-ub
GSK3A (mouse) NPNYTEFkFPQIKAH K355-ub
GSK3A (rat) NPNYTEFKFPQIKAH K355
GSK3A (cow) NPNYTEFKFPQIKAH K355
K366
IKAHPWTKVFKSRTP
0 1
GSK3A (human) IKAHPWTKVFKSRTP K366
GSK3A (mouse) IKAHPWTKVFKSSkT K366
GSK3A (rat) IKAHPWTkVFKSRTP K366-ac
GSK3A (cow) IKAHPWTKVFKSRTP K366
K366-ub
IKAHPWTkVFKSRTP
0 2
GSK3A (human) IKAHPWTkVFKSRTP K366-ub
GSK3A (mouse) IKAHPWTKVFKSSkT K366
GSK3A (rat) IKAHPWTKVFKSRTP K366
GSK3A (cow) IKAHPWTKVFKSRTP K366
R371
WTkVFKSRTPPEAIA
0 1
GSK3A (human) WTkVFKSRTPPEAIA R371
GSK3A (mouse) TKVFKSSkTPPEAIA K372-ub
GSK3A (rat) WTkVFKSRTPPEAIA R371
GSK3A (cow) WTKVFKSRTPPEAIA R371
T480-p
TDATPTLtNSS____
0 1
GSK3A (human) TDATPTLtNSS____ T480-p
GSK3A (mouse) DATTATLASSS____ A487
GSK3A (rat) PDATPTLTNSS____ T480
GSK3A (cow) LLQPPHLLCPL____ L492