Other Species / Isoforms
  GRK2 (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
Y13-p
AVLADVSyLMAMEkS
Upstream
Downstream
5 0
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Putative in vivo kinases:
  • Src (human)
Treatment
  • carbachol
  • isoproterenol
GRK2 (human) AVLADVSyLMAMEkS Y13-p
GRK2 (mouse) AVLADVSyLMAMEKS Y13-p
GRK2 (rat) AVLADVSYLMAMEKS Y13
GRK2 (cow) AVLADVSyLMAMEKS Y13-p
K19-ub
SyLMAMEkSkATPAA
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • ARRB2 (human)
Treatment
  • isoproterenol
  • siRNA
GRK2 (human) SyLMAMEkSkATPAA K19-ub
GRK2 (mouse) SyLMAMEKSKATPAA K19
GRK2 (rat) SYLMAMEKSKATPAA K19
GRK2 (cow) SyLMAMEKSKATPAA K19
K21-ub
LMAMEkSkATPAARA
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • ARRB2 (human)
Treatment
  • isoproterenol
  • siRNA
GRK2 (human) LMAMEkSkATPAARA K21-ub
GRK2 (mouse) LMAMEKSKATPAARA K21
GRK2 (rat) LMAMEKSKATPAARA K21
GRK2 (cow) LMAMEKSKATPAARA K21
S29-p
ATPAARAskkILLPE
Upstream
Downstream
2 0
Effects on Modified Protein
  • activity, induced
Kinase, in vitro:
  • PKCA (rat)
  • PKCD (rat)
  • PKCG (human)
Putative in vivo kinases:
  • PKCA (human)
Treatment
  • phorbol_ester
GRK2 (human) ATPAARAskkILLPE S29-p
GRK2 (mouse) ATPAARASKKILLPE S29
GRK2 (rat) ATPAARAsKKILLPE S29-p
GRK2 (cow) ATPAARASKKILLPE S29
K30-ub
TPAARAskkILLPEP
Upstream
Downstream
1 0
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • ARRB2 (human)
Treatment
  • isoproterenol
  • siRNA
GRK2 (human) TPAARAskkILLPEP K30-ub
GRK2 (mouse) TPAARASKKILLPEP K30
GRK2 (rat) TPAARAsKKILLPEP K30
GRK2 (cow) TPAARASKKILLPEP K30
K31-ub
PAARAskkILLPEPS
Upstream
Downstream
1 2
Effects on Modified Protein
  • protein degradation
Regulatory protein:
  • ARRB2 (human)
Treatment
  • isoproterenol
  • siRNA
GRK2 (human) PAARAskkILLPEPS K31-ub
GRK2 (mouse) PAARASKKILLPEPS K31
GRK2 (rat) PAARAsKKILLPEPS K31
GRK2 (cow) PAARASKKILLPEPS K31
K45-ub
SIRSVMQkYLEDrGE
0 2
GRK2 (human) SIRSVMQkYLEDrGE K45-ub
GRK2 (mouse) SIRSVMQKYLEDRGE K45
GRK2 (rat) SIRSVMQKYLEDRGE K45
GRK2 (cow) SIRSVMQKYLEDRGE K45
R50-m1
MQkYLEDrGEVtFEk
0 1
GRK2 (human) MQkYLEDrGEVtFEk R50-m1
GRK2 (mouse) MQKYLEDRGEVTFEK R50
GRK2 (rat) MQKYLEDRGEVTFEK R50
GRK2 (cow) MQKYLEDRGEVTFEK R50
T54-p
LEDrGEVtFEkIFSQ
0 1
GRK2 (human) LEDrGEVtFEkIFSQ T54-p
GRK2 (mouse) LEDRGEVTFEKIFSQ T54
GRK2 (rat) LEDRGEVTFEKIFSQ T54
GRK2 (cow) LEDRGEVTFEKIFSQ T54
K57-ub
rGEVtFEkIFSQkLG
Upstream
0 3
Treatment
  • MG132
GRK2 (human) rGEVtFEkIFSQkLG K57-ub
GRK2 (mouse) RGEVTFEKIFSQKLG K57
GRK2 (rat) RGEVTFEKIFSQKLG K57
GRK2 (cow) RGEVTFEKIFSQKLG K57
K62-ub
FEkIFSQkLGYLLFR
Upstream
0 5
Treatment
  • MG132
GRK2 (human) FEkIFSQkLGYLLFR K62-ub
GRK2 (mouse) FEKIFSQKLGYLLFR K62
GRK2 (rat) FEKIFSQKLGYLLFR K62
GRK2 (cow) FEKIFSQKLGYLLFR K62
Y86-p
ARPLVEFyEEIKKyE
Upstream
Downstream
5 0
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Putative in vivo kinases:
  • Src (human)
Treatment
  • carbachol
  • isoproterenol
GRK2 (human) ARPLVEFyEEIKKyE Y86-p
GRK2 (mouse) AKPLVEFyEEIKKyE Y86-p
GRK2 (rat) AKPLVEFYEEIEKYE Y86
GRK2 (cow) AKPLVEFyEEIKKyE Y86-p
Y92-p
FyEEIKKyEkLETEE
Upstream
Downstream
5 0
Effects on Modified Protein
  • molecular association, regulation
  • protein degradation
Putative in vivo kinases:
  • Src (human)
Treatment
  • carbachol
  • isoproterenol
GRK2 (human) FyEEIKKyEkLETEE Y92-p
GRK2 (mouse) FyEEIKKyEKLETEE Y92-p
GRK2 (rat) FYEEIEKYEKLETEE Y92
GRK2 (cow) FyEEIKKyEKLETEE Y92-p
K94-ub
EEIKKyEkLETEEER
0 2
GRK2 (human) EEIKKyEkLETEEER K94-ub
GRK2 (mouse) EEIKKyEKLETEEER K94
GRK2 (rat) EEIEKYEKLETEEER K94
GRK2 (cow) EEIKKyEKLETEEER K94
K115-ub
IFDSYIMkELLACSH
0 2
GRK2 (human) IFDSYIMkELLACSH K115-ub
GRK2 (mouse) IFDSYIMKELLACSH K115
GRK2 (rat) IFDSYIMKELLACSH K115
GRK2 (cow) IFDTYIMKELLACSH K115
K126-ub
ACSHPFSkSATEHVQ
0 3
GRK2 (human) ACSHPFSkSATEHVQ K126-ub
GRK2 (mouse) ACSHPFSKNATEHVQ K126
GRK2 (rat) ACSHPFSKNATEHVQ K126
GRK2 (cow) ACSHPFSKSAIEHVQ K126
K138-ub
HVQGHLGkkQVPPDL
0 1
GRK2 (human) HVQGHLGkkQVPPDL K138-ub
GRK2 (mouse) HVQGHLVKKQVPPDL K138
GRK2 (rat) HVQGHLVKKQVPPDL K138
GRK2 (cow) HVQGHLVKKQVPPDL K138
K139-ub
VQGHLGkkQVPPDLF
0 2
GRK2 (human) VQGHLGkkQVPPDLF K139-ub
GRK2 (mouse) VQGHLVKKQVPPDLF K139
GRK2 (rat) VQGHLVKKQVPPDLF K139
GRK2 (cow) VQGHLVKKQVPPDLF K139
K164-ub
LRGDVFQkFIESDkF
0 2
GRK2 (human) LRGDVFQkFIESDkF K164-ub
GRK2 (mouse) LRGDVFQKFIESDKF K164
GRK2 (rat) LRGDVFHKFIESDKF K164
GRK2 (cow) LRGDVFQKFIESDKF K164
K170-ub
QkFIESDkFTRFCQW
Upstream
0 3
Treatment
  • MG132
GRK2 (human) QkFIESDkFTRFCQW K170-ub
GRK2 (mouse) QKFIESDKFTRFCQW K170
GRK2 (rat) HKFIESDKFTRFCQW K170
GRK2 (cow) QKFIESDKFTRFCQW K170
K220-ub
TGKMYAMkCLDKKRI
Downstream
1 2
Effects on Modified Protein
  • acetylation
  • phosphorylation
Effects on Biological Processes:
  • cell adhesion, induced
  • cell motility, induced
  • cytoskeletal reorganization
GRK2 (human) TGKMYAMkCLDKKRI K220-ub
GRK2 (mouse) TGKMYAMKCLDKKRI K220
GRK2 (rat) TGKMYAMKCLDKKRI K220
GRK2 (cow) TGKMYAMKCLDKKRI K220
S247-p
RIMLSLVstGDCPFI
0 1
GRK2 (human) RIMLSLVstGDCPFI S247-p
GRK2 (mouse) RIMLSLVSTGDCPFI S247
GRK2 (rat) RIMLSLVSTGDCPFI S247
GRK2 (cow) RIMLSLVSTGDCPFI S247
T248-p
IMLSLVstGDCPFIV
0 1
GRK2 (human) IMLSLVstGDCPFIV T248-p
GRK2 (mouse) IMLSLVSTGDCPFIV T248
GRK2 (rat) IMLSLVSTGDCPFIV T248
GRK2 (cow) IMLSLVSTGDCPFIV T248
T263-p
CMSYAFHtPDKLSFI
0 1
GRK2 (human) CMSYAFHtPDKLSFI T263-p
GRK2 (mouse) CMSYAFHTPDKLSFI T263
GRK2 (rat) CMSYAFHTPDKLSFI T263
GRK2 (cow) CMSYAFHTPDKLSFI T263
K319-ub
FVVYRDLkPANILLD
0 2
GRK2 (human) FVVYRDLkPANILLD K319-ub
GRK2 (mouse) FVVYRDLKPANILLD K319
GRK2 (rat) FVVYRDLKPANILLD K319
GRK2 (cow) FVVYRDLKPANILLD K319
K344-ub
GLACDFSkkKPHASV
0 5
GRK2 (human) GLACDFSkkKPHASV K344-ub
GRK2 (mouse) GLACDFSkKRPHASV K344-ub
GRK2 (rat) GLACDFSKKKPHASV K344
GRK2 (cow) GLACDFSKKKPHASV K344
K345-ub
LACDFSkkKPHASVG
0 1
GRK2 (human) LACDFSkkKPHASVG K345-ub
GRK2 (mouse) LACDFSkKRPHASVG K345
GRK2 (rat) LACDFSKKKPHASVG K345
GRK2 (cow) LACDFSKKKPHASVG K345
Y356-p
ASVGTHGyMAPEVLQ
0 71
GRK2 (human) ASVGTHGyMAPEVLQ Y356-p
GRK2 (mouse) ASVGTHGyMAPEVLQ Y356-p
GRK2 (rat) ASVGTHGYMAPEVLQ Y356
GRK2 (cow) ASVGTHGYMAPEVLQ Y356
S416-p
MAVELPDsFSPELRS
0 1
GRK2 (human) MAVELPDsFSPELRS S416-p
GRK2 (mouse) MAVELPDSFSPELRS S416
GRK2 (rat) MAVELPDSFSPELRS S416
GRK2 (cow) MAVELPDSFSPELRS S416
K448-ub
GRGAQEVkESPFFRS
0 2
GRK2 (human) GRGAQEVkESPFFRS K448-ub
GRK2 (mouse) GRGAQEVKESPFFRS K448
GRK2 (rat) GRGAQEIKESPFFRS K448
GRK2 (cow) GRGAQEVKESPFFRS K448
S487-p
ADAFDIGsFDEEDTK
0 5
GRK2 (human) ADAFDIGsFDEEDTK S487-p
GRK2 (mouse) ADAFDIGsFDEEDTK S487-p
GRK2 (rat) ADAFDIGSFDEEDTK S487
GRK2 (cow) ADAFDIGSFDEEDTK S487
K497-ub
EEDTKGIkLLDsDQE
0 2
GRK2 (human) EEDTKGIkLLDsDQE K497-ub
GRK2 (mouse) EEDTKGIKLLDSDQE K497
GRK2 (rat) EEDTKGIKLLDSDQE K497
GRK2 (cow) EEDTKGIKLLDSDQE K497
S501-p
KGIkLLDsDQELyRN
0 1
GRK2 (human) KGIkLLDsDQELyRN S501-p
GRK2 (mouse) KGIKLLDSDQELYRN S501
GRK2 (rat) KGIKLLDSDQELYRN S501
GRK2 (cow) KGIKLLDSDQELYRN S501
Y506-p
LDsDQELyRNFPLTI
0 1
GRK2 (human) LDsDQELyRNFPLTI Y506-p
GRK2 (mouse) LDSDQELYRNFPLTI Y506
GRK2 (rat) LDSDQELYRNFPLTI Y506
GRK2 (cow) LDSDQELYRNFPLTI Y506
K557-ub
EEDYALGkDCIMHGY
0 2
GRK2 (human) EEDYALGkDCIMHGY K557-ub
GRK2 (mouse) EEDYALGKDCIVHGY K557
GRK2 (rat) EEDYALGKDCIMHGY K557
GRK2 (cow) EEDYALGKDCIMHGY K557
K628-ub
LLKIRGGkQFILQCD
0 3
GRK2 (human) LLKIRGGkQFILQCD K628-ub
GRK2 (mouse) LLKIRGGKQFVLQCD K628
GRK2 (rat) LLKIRGGKQFVLQCD K628
GRK2 (cow) LLKIRGGKQFVLQCD K628
K644-ac
DPELVQWkKELRDAY
0 1
GRK2 (human) DPELVQWkKELRDAY K644-ac
GRK2 (mouse) DPELVQWKKELRDAY K644
GRK2 (rat) DPELVQWKKELRDAY K644
GRK2 (cow) DPELVQWKKELRDAY K644
K644-ub
DPELVQWkKELRDAY
0 1
GRK2 (human) DPELVQWkKELRDAY K644-ub
GRK2 (mouse) DPELVQWKKELRDAY K644
GRK2 (rat) DPELVQWKKELRDAY K644
GRK2 (cow) DPELVQWKKELRDAY K644
S670-p
KMKNKPRsPVVELsk
Upstream
Downstream
5 57
Effects on Modified Protein
  • acetylation
  • molecular association, regulation
  • phosphorylation
  • protein degradation
  • ubiquitination
Effects on Biological Processes:
  • cell adhesion, induced
  • cell cycle regulation
  • cell growth, altered
  • cell motility, induced
  • chromatin organization, altered
  • cytoskeletal reorganization
Kinase, in vitro:
  • CDK2 (human)
Treatment
  • aphidicolin
  • EGF
  • LRRK2-IN-1
  • selumetinib
  • thymidine
  • U0126
GRK2 (human) KMKNKPRsPVVELsk S670-p
GRK2 (mouse) KMKNKPRsPVVELsK S670-p
GRK2 (rat) KMKNKPRsPVVELSK S670-p
GRK2 (cow) KMKNKPRsPVVELSK S670-p
S676-p
RsPVVELskVPLVQr
0 2
GRK2 (human) RsPVVELskVPLVQr S676-p
GRK2 (mouse) RsPVVELsKVPLIQR S676-p
GRK2 (rat) RsPVVELSKVPLIQR S676
GRK2 (cow) RsPVVELSKVPLIQR S676
K677-ub
sPVVELskVPLVQrG
Upstream
0 4
Treatment
  • MG132
GRK2 (human) sPVVELskVPLVQrG K677-ub
GRK2 (mouse) sPVVELsKVPLIQRG K677
GRK2 (rat) sPVVELSKVPLIQRG K677
GRK2 (cow) sPVVELSKVPLIQRG K677
R683-m1
skVPLVQrGsANGL_
0 1
GRK2 (human) skVPLVQrGsANGL_ R683-m1
GRK2 (mouse) sKVPLIQRGSANGL_ R683
GRK2 (rat) SKVPLIQRGSANGL_ R683
GRK2 (cow) SKVPLIQRGsANGL_ R683
S685-p
VPLVQrGsANGL___
Upstream
Downstream
3 12
Effects on Modified Protein
  • molecular association, regulation
Treatment
  • angiotensin_2
  • isoproterenol
GRK2 (human) VPLVQrGsANGL___ S685-p
GRK2 (mouse) VPLIQRGSANGL___ S685
GRK2 (rat) VPLIQRGSANGL___ S685
GRK2 (cow) VPLIQRGsANGL___ S685-p