Other Species / Isoforms
  Fyn (human)      LTP 

LTP (Low Throughput Papers) : The number of records in which this modification site was determined using methods other than discovery mass spectrometry.

 HTP 

HTP (High Throughput Papers): The number of records in which this modification site was assigned using ONLY proteomic discovery mass spectrometry.

 
T12-p
QCKDKEAtkLTEERD
Upstream
1 2
Treatment
  • leflunomide
  • PP2
  • UV
Fyn (human) QCKDKEAtkLTEERD T12-p
Fyn iso2 (human) QCKDKEATKLTEERD T12
Fyn iso3 (human) QCKDKEATKLTEERD T12
Fyn (mouse) QCKDKEAAKLTEERD A12
Fyn (rat) QCKDKEAAKLTEERD A12
K13-ub
CKDKEAtkLTEERDG
0 1
Fyn (human) CKDKEAtkLTEERDG K13-ub
Fyn iso2 (human) CKDKEATKLTEERDG K13
Fyn iso3 (human) CKDKEATKLTEERDG K13
Fyn (mouse) CKDKEAAKLTEERDG K13
Fyn (rat) CKDKEAAKLTEERDG K13
S21-p
LTEERDGsLNQssGy
Upstream
Downstream
1 49
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • phosphorylation
Effects on Biological Processes:
  • cell motility, altered
Kinase, in vitro:
  • PKACA (human)
Putative in vivo kinases:
  • PKACA (human)
Treatment
  • angiotensin_2
  • colforsin
  • H-89
  • MG132
  • nocodazole
  • SII_angiotensin_2
Fyn (human) LTEERDGsLNQssGy S21-p
Fyn iso2 (human) LTEERDGSLNQSSGY S21
Fyn iso3 (human) LTEERDGSLNQSSGY S21
Fyn (mouse) LTEERDGsLNQssGy S21-p
Fyn (rat) LTEERDGsLNQSSGY S21-p
S25-p
RDGsLNQssGyRyGT
0 4
Fyn (human) RDGsLNQssGyRyGT S25-p
Fyn iso2 (human) RDGSLNQSSGYRYGT S25
Fyn iso3 (human) RDGSLNQSSGYRYGT S25
Fyn (mouse) RDGsLNQssGyRYGT S25-p
Fyn (rat) RDGsLNQSSGYRYGT S25
S26-p
DGsLNQssGyRyGTD
0 4
Fyn (human) DGsLNQssGyRyGTD S26-p
Fyn iso2 (human) DGSLNQSSGYRYGTD S26
Fyn iso3 (human) DGSLNQSSGYRYGTD S26
Fyn (mouse) DGsLNQssGyRYGTD S26-p
Fyn (rat) DGsLNQSSGYRYGTD S26
Y28-p
sLNQssGyRyGTDPT
Upstream
2 13
Kinase, in vitro:
  • Fyn (human)
  • PDGFRB (human)
Fyn (human) sLNQssGyRyGTDPT Y28-p
Fyn iso2 (human) SLNQSSGYRYGTDPT Y28
Fyn iso3 (human) SLNQSSGYRYGTDPT Y28
Fyn (mouse) sLNQssGyRYGTDPT Y28-p
Fyn (rat) sLNQSSGYRYGTDPT Y28
Y30-p
NQssGyRyGTDPTPQ
Upstream
1 0
Kinase, in vitro:
  • Fyn (human)
Fyn (human) NQssGyRyGTDPTPQ Y30-p
Fyn iso2 (human) NQSSGYRYGTDPTPQ Y30
Fyn iso3 (human) NQSSGYRYGTDPTPQ Y30
Fyn (mouse) NQssGyRYGTDPTPQ Y30
Fyn (rat) NQSSGYRYGTDPTPQ Y30
Y39-p
TDPTPQHyPSFGVTS
Upstream
1 1
Kinase, in vitro:
  • Fyn (human)
Fyn (human) TDPTPQHyPSFGVTS Y39-p
Fyn iso2 (human) TDPTPQHYPSFGVTS Y39
Fyn iso3 (human) TDPTPQHYPSFGVTS Y39
Fyn (mouse) TDPTPQHYPSFGVTS Y39
Fyn (rat) TDPTPQHYPSFGVTS Y39
Y91-p
VTLFVALyDYEARTE
0 11
Fyn (human) VTLFVALyDYEARTE Y91-p
Fyn iso2 (human) VTLFVALYDYEARTE Y91
Fyn iso3 (human) VTLFVALYDYEARTE Y91
Fyn (mouse) VTLFVALyDYEARTE Y91-p
Fyn (rat) VTLFVALYDYEARTE Y91
Y150
SIQAEEWYFGKLGRK
0 4
Fyn (human) SIQAEEWYFGKLGRK Y150
Fyn iso2 (human) SIQAEEWYFGKLGRK Y150
Fyn iso3 (human) SIQAEEWYFGKLGRK Y150
Fyn (mouse) SIQAEEWYFGKLGRK Y150
Fyn (rat) SIQAEEWyFGKLGRK Y150-p
Y185-p
SETTKGAysLSIRDW
Upstream
Downstream
1 313
Effects on Modified Protein
  • enzymatic activity, induced
  • molecular association, regulation
Kinase, in vitro:
  • Fyn (human)
Regulatory protein:
  • EGFR (human)
Treatment
  • nocodazole
Fyn (human) SETTKGAysLSIRDW Y185-p
Fyn iso2 (human) SETTKGAYSLSIRDW Y185
Fyn iso3 (human) SETTKGAYSLSIRDW Y185
Fyn (mouse) SETTKGAysLSIRDW Y185-p
Fyn (rat) SETTKGAysLSIRDW Y185-p
S186-p
ETTKGAysLSIRDWD
0 12
Fyn (human) ETTKGAysLSIRDWD S186-p
Fyn iso2 (human) ETTKGAYSLSIRDWD S186
Fyn iso3 (human) ETTKGAYSLSIRDWD S186
Fyn (mouse) ETTKGAysLSIRDWD S186-p
Fyn (rat) ETTKGAysLSIRDWD S186-p
K196-ub
IRDWDDMkGDHVKHY
0 1
Fyn (human) IRDWDDMkGDHVKHY K196-ub
Fyn iso2 (human) IRDWDDMKGDHVKHY K196
Fyn iso3 (human) IRDWDDMKGDHVKHY K196
Fyn (mouse) IRDWDDMKGDHVKHY K196
Fyn (rat) IRDWDDMKGDHVKHY K196
Y213-p
RKLDNGGyyITTRAQ
Upstream
Downstream
2 1819
Effects on Modified Protein
  • enzymatic activity, induced
  • intracellular localization
  • molecular association, regulation
Effects on Biological Processes:
  • apoptosis, inhibited
Kinase, in vitro:
  • Fyn (human)
Regulatory protein:
  • EGFR (human)
  • FGFR1 (human)
Treatment
  • ephrin_B1
  • erlotinib
Fyn (human) RKLDNGGyyITTRAQ Y213-p
Fyn iso2 (human) RKLDNGGYYITTRAQ Y213
Fyn iso3 (human) RKLDNGGYYITTRAQ Y213
Fyn (mouse) RKLDNGGyyITTRAQ Y213-p
Fyn (rat) RKLDNGGyyITTRAQ Y213-p
Y214-p
KLDNGGyyITTRAQF
Upstream
Downstream
2 677
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, induced
  • molecular association, regulation
  • protein conformation
Kinase, in vitro:
  • Fyn (human)
Treatment
  • anti-CD3
  • imatinib
  • phorbol_ester
Fyn (human) KLDNGGyyITTRAQF Y214-p
Fyn iso2 (human) KLDNGGYYITTRAQF Y214
Fyn iso3 (human) KLDNGGYYITTRAQF Y214
Fyn (mouse) KLDNGGyyITTRAQF Y214-p
Fyn (rat) KLDNGGyyITTRAQF Y214-p
S257-p
MPRLTDLsVkTkDVW
Upstream
0 5
Treatment
  • MG132_withdrawal
Fyn (human) MPRLTDLsVkTkDVW S257-p
Fyn iso2 (human) gap -
Fyn iso3 (human) gap -
Fyn (mouse) MPRLTDLsVKTKDVW S257-p
Fyn (rat) MPRLTDLSVKTKDVW S257
K259-ub
RLTDLsVkTkDVWEI
0 1
Fyn (human) RLTDLsVkTkDVWEI K259-ub
Fyn iso2 (human) gap -
Fyn iso3 (human) gap -
Fyn (mouse) RLTDLsVKTKDVWEI K259
Fyn (rat) RLTDLSVKTKDVWEI K259
K261-ub
TDLsVkTkDVWEIPR
0 1
Fyn (human) TDLsVkTkDVWEIPR K261-ub
Fyn iso2 (human) gap -
Fyn iso3 (human) gap -
Fyn (mouse) TDLsVKTKDVWEIPR K261
Fyn (rat) TDLSVKTKDVWEIPR K261
K275-ub
RESLQLIkRLGNGQF
0 1
Fyn (human) RESLQLIkRLGNGQF K275-ub
Fyn iso2 (human) gap -
Fyn iso3 (human) gap -
Fyn (mouse) RESLQLIKRLGNGQF K275
Fyn (rat) RESLQLIKRLGNGQF K275
-
gap
0 4
Fyn (human) gap -
Fyn iso2 (human) AWEVARRsLCLEkKL S267-p
Fyn iso3 (human) gap -
Fyn (mouse) gap -
Fyn (rat) gap -
-
gap
0 1
Fyn (human) gap -
Fyn iso2 (human) RRsLCLEkKLGQGCF K272-ub
Fyn iso3 (human) gap -
Fyn (mouse) gap -
Fyn (rat) gap -
T289-p
FGEVWMGtWNGNtKV
0 1
Fyn (human) FGEVWMGtWNGNtKV T289-p
Fyn iso2 (human) FAEVWLGTWNGNTKV T286
Fyn iso3 (human) LVQHYSGTWNGNTKV T234
Fyn (mouse) FGEVWMGTWNGNTKV T289
Fyn (rat) FGEVWMGTWNGNTKV T289
T294-p
MGtWNGNtKVAIktL
0 1
Fyn (human) MGtWNGNtKVAIktL T294-p
Fyn iso2 (human) LGTWNGNTKVAIKTL T291
Fyn iso3 (human) SGTWNGNTKVAIKTL T239
Fyn (mouse) MGTWNGNTKVAIKTL T294
Fyn (rat) MGTWNGNTKVAIKTL T294
K299-ub
GNtKVAIktLkPGTM
0 1
Fyn (human) GNtKVAIktLkPGTM K299-ub
Fyn iso2 (human) GNTKVAIKTLKPGTM K296
Fyn iso3 (human) GNTKVAIKTLKPGTM K244
Fyn (mouse) GNTKVAIKTLKPGTM K299
Fyn (rat) GNTKVAIKTLKPGTM K299
T300-p
NtKVAIktLkPGTMs
0 1
Fyn (human) NtKVAIktLkPGTMs T300-p
Fyn iso2 (human) NTKVAIKTLKPGTMS T297
Fyn iso3 (human) NTKVAIKTLKPGTMS T245
Fyn (mouse) NTKVAIKTLKPGTMS T300
Fyn (rat) NTKVAIKTLKPGTMS T300
K302-ub
KVAIktLkPGTMsPE
0 1
Fyn (human) KVAIktLkPGTMsPE K302-ub
Fyn iso2 (human) KVAIKTLKPGTMSPE K299
Fyn iso3 (human) KVAIKTLKPGTMSPE K247
Fyn (mouse) KVAIKTLKPGTMSPE K302
Fyn (rat) KVAIKTLKPGTMSPE K302
S307-p
tLkPGTMsPESFLEE
0 1
Fyn (human) tLkPGTMsPESFLEE S307-p
Fyn iso2 (human) TLKPGTMSPESFLEE S304
Fyn iso3 (human) TLKPGTMSPESFLEE S252
Fyn (mouse) TLKPGTMSPESFLEE S307
Fyn (rat) TLKPGTMSPESFLEE S307
K319-ub
LEEAQIMkKLKHDKL
0 1
Fyn (human) LEEAQIMkKLKHDKL K319-ub
Fyn iso2 (human) LEEAQIMKKLKHDKL K316
Fyn iso3 (human) LEEAQIMKKLKHDKL K264
Fyn (mouse) LEEAQIMKkLkHDKL K319
Fyn (rat) LEEAQIMKKLKHDKL K319
K320
EEAQIMkKLKHDKLV
0 1
Fyn (human) EEAQIMkKLKHDKLV K320
Fyn iso2 (human) EEAQIMKKLKHDKLV K317
Fyn iso3 (human) EEAQIMKKLKHDKLV K265
Fyn (mouse) EEAQIMKkLkHDKLV K320-m1
Fyn (rat) EEAQIMKKLKHDKLV K320
K322
AQIMkKLKHDKLVQL
0 1
Fyn (human) AQIMkKLKHDKLVQL K322
Fyn iso2 (human) AQIMKKLKHDKLVQL K319
Fyn iso3 (human) AQIMKKLKHDKLVQL K267
Fyn (mouse) AQIMKkLkHDKLVQL K322-m1
Fyn (rat) AQIMKKLKHDKLVQL K322
Y339-p
VVSEEPIyIVTEYMN
0 4
Fyn (human) VVSEEPIyIVTEYMN Y339-p
Fyn iso2 (human) VVSEEPIYIVTEYMN Y336
Fyn iso3 (human) VVSEEPIYIVTEYMN Y284
Fyn (mouse) VVSEEPIyIVTEYMS Y339-p
Fyn (rat) VVSEEPIYIVTEYMN Y339
K355-ub
GSLLDFLkDGEGRAL
0 2
Fyn (human) GSLLDFLkDGEGRAL K355-ub
Fyn iso2 (human) GSLLDFLKDGEGRAL K352
Fyn iso3 (human) GSLLDFLKDGEGRAL K300
Fyn (mouse) GSLLDFLKDGEGRAL K355
Fyn (rat) GSLLDFLKDGEGRAL K355
S393
YIHRDLRSANILVGN
0 1
Fyn (human) YIHRDLRSANILVGN S393
Fyn iso2 (human) YIHRDLRSANILVGN S390
Fyn iso3 (human) YIHRDLRSANILVGN S338
Fyn (mouse) YIHRDLRsANILVGN S393-p
Fyn (rat) YIHRDLRSANILVGN S393
K405-ub
VGNGLICkIADFGLA
0 2
Fyn (human) VGNGLICkIADFGLA K405-ub
Fyn iso2 (human) VGNGLICKIADFGLA K402
Fyn iso3 (human) VGNGLICKIADFGLA K350
Fyn (mouse) VGNGLICKIADFGLA K405
Fyn (rat) VGNGLICKIADFGLA K405
Y420-p
RLIEDNEytARQGAK
Upstream
Downstream
24 3124
Fyn (human)
Y420-p
Fyn iso2 (human)
Y417-p
Fyn iso3 (human)
Y365-p
Fyn (mouse)
Y420-p
Fyn (rat)
Y420-p
Effects on Modified Protein
  • molecular association, regulation
Kinase, in vitro:
  • Fyn (human)
Phosphatases, in vitro:
  • STEP (human)
Putative in vivo kinases:
  • AXL (human)
  • Fyn (human)
Putative upstream phosphatases:
  • STEP (human)
Regulatory protein:
  • EGFR (human)
  • TLR4 (human)
Treatment
  • anti-CD3
  • cell_detachment
  • dasatinib
  • ephrin_B1
  • ephrin_B2
  • Fas
  • FGF2
  • fibronectin
  • H2O2
  • HGF
  • imatinib
  • LPA
  • LPS
  • NAC
  • phorbol_ester
  • PP2
  • serum_starvation
  • siRNA
  • Su11274
  • SU6656
  • U0126
  • vanadate
Fyn (human) RLIEDNEytARQGAK Y420-p
Fyn iso2 (human) RLIEDNEyTARQGAK Y417-p
Fyn iso3 (human) RLIEDNEYTARQGAK Y365
Fyn (mouse) RLIEDNEytARQGAK Y420-p
Fyn (rat) RLIEDNEyTARQGAK Y420-p
T421-p
LIEDNEytARQGAKF
0 24
Fyn (human) LIEDNEytARQGAKF T421-p
Fyn iso2 (human) LIEDNEyTARQGAKF T418
Fyn iso3 (human) LIEDNEYTARQGAKF T366
Fyn (mouse) LIEDNEytARQGAKF T421-p
Fyn (rat) LIEDNEyTARQGAKF T421
Y440-p
TAPEAALyGRFTIKS
Upstream
1 545
Regulatory protein:
  • ZAP70 (human)
Treatment
  • imatinib
  • U0126
Fyn (human) TAPEAALyGRFTIKS Y440-p
Fyn iso2 (human) TAPEAALYGRFTIKS Y437
Fyn iso3 (human) TAPEAALYGRFTIKS Y385
Fyn (mouse) TAPEAALyGRFTIKS Y440-p
Fyn (rat) TAPEAALyGRFTIKS Y440-p
Y531-p
FTATEPQyQPGENL_
Upstream
Downstream
19 1052
Effects on Modified Protein
  • activity, induced
  • enzymatic activity, inhibited
  • intracellular localization
  • phosphorylation
  • protein conformation
Effects on Biological Processes:
  • cell growth, altered
Kinase, in vitro:
  • CSK (mouse)
Phosphatases, in vitro:
  • CD45 (human)
Putative in vivo kinases:
  • CSK (human)
Treatment
  • anti-CD3
  • H2O2
  • PAO
  • phorbol_ester
  • serum_starvation
Fyn (human) FTATEPQyQPGENL_ Y531-p
Fyn iso2 (human) FTATEPQyQPGENL_ Y528-p
Fyn iso3 (human) FTATEPQYQPGENL_ Y476
Fyn (mouse) FTATEPQyQPGENL_ Y531-p
Fyn (rat) FTATEPQyQPGENL_ Y531-p